The G-protein-coupled receptor (GPCR) superfamily is comprised of an estimated 600-1,000 members and is the largest known class of molecular targets with proven therapeutic value. Thermo Fisher Scientific’s experienced team of GPCR biologists has generated a highly validated and novel family of GPCR cell line products to enable your discovery programs.

The portfolio contains two distinct assay platforms each utilizing FRET as the assay readout: Tango GPCR cell lines and GeneBLAzer GPCR cell lines. Each GPCR cell line platform is available in two cell states: Division Arrested non-dividing cells and normal dividing cells. Click through our cell line product table below and capability links to the right to see how we can help accelerate your drug discovery efforts.

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Select a GPCR receptor family

Acetylcholine (Muscarinic)Complement ComponentGlucagonNicotinic AcidRelaxin
AdenosineCorticotropin Releasing FactorGonadotropin Releasing HormoneOpioidSecretin
AdrenoreceptorDopamineHistamineOrexinSerotonin
AngiotensinEndothelial Differentiation GeneKiSS1OrphanSomatostatin
BradykininEndothelinLeukotrienePlatelet Activating FactorTachykinin
CalcitoninFormyl Peptide-LikeMelanin-concentrating HormoneProkineticinVasopressin & Oxytocin
Calcium Sensing GalaninMelanocortinProlactin Releasing- PeptideVIP & PACAP
CannabinoidGastrin Releasing PeptideMelatoninProstanoid
ChemokineGhrelinMotilinProtease Activated 
CholecystokininGastric Inhibitory Polypeptide NeuropeptideP2Y (Purinergic) 
  Assay Performance DataDividing CellsDivision Arrested CellsAvailable in 
FamilyReceptorGeneblazer TechnologyTango TechnologyCat. No.Cat. No.SelectScreen ServiceConfirmed  Readout
Acetylcholine (Muscarinic)M1  K1710  Ca²+(Fluo-4)
Acetylcholine (Muscarinic)M1  K1735K1365✓Ca²+(Fluo-4), Phospho-ERK2
Acetylcholine (Muscarinic)M1  K1861   Ca²+(Fluo-4), Phospho-ERK2
Acetylcholine (Muscarinic)CHRM2 (M2)  K1564 ✓Ca²+(Fluo-4)
Acetylcholine (Muscarinic)M3  K1716 ✓Ca²+(Fluo-4)
Acetylcholine (Muscarinic)M4  K1741 ✓Ca²+(Fluo-4)
Acetylcholine (Muscarinic)M4  K1818  ✓Phospho-ERK2
Acetylcholine (Muscarinic)M5  K1728 ✓Ca²+(Fluo-4)
AdenosineADORA1  K1445K1601✓ 
AdenosineADORA2A  K1530K1345 cAMP
AdenosineADORA2B  K1780   
AdenosineADORA3  K1837   
AdrenoreceptorADRA1A  K1470 K1577✓Ca²+(Fluo-4)
AdrenoreceptorADRA1B  K1471  ✓Ca²+(Fluo-4)
AdrenoreceptorADRA2A  K1743 ✓Ca²+(Fluo-4)
AdrenoreceptorADRA2A  K1604 K1607✓ 
AdrenoreceptorADRB1  K1553 ✓cAMP
AdrenoreceptorADRB2  K1472   cAMP, ERK2
AdrenoreceptorADRB3  K1745K1473✓cAMP
AngiotensinAGTR1  K1443 ✓Ca²+(Fluo-4), Phospho-ERK2
Angiotensin-LikeAGTRL1  K1754K1762✓ 
BradykininBDKRB1  K1734K1363✓Ca²+(Fluo-4),
Phospho-ERK2
BradykininBDKRB2  K1790 ✓ 
CalcitoninCALCR  K1480 ✓cAMP
CalcitoninCALCRL: RAMP1  K1437 ✓cAMP
CalcitoninCALCRL: RAMP2  K1438  cAMP
CalcitoninCALCRL: RAMP3  K1439 ✓cAMP
Calcium SensingCASR  K1833 ✓Ca²+(Fluo-4)
CannabinoidCNR1  K1513  ✓ 
CannabinoidCNR2  K1512K1567✓ 
ChemokineCXCR1  K1807  ✓ 
ChemokineCXCR2  K1521 ✓ Ca²+(Fluo-4)
ChemokineCXCR3  K1829 ✓ Ca²+(Fluo-4)
ChemokineCXCR4  K1779 ✓ Ca²+(Fluo-4)
ChemokineCXCR6  K1563 ✓ 
ChemokineCXCR7  K1832 ✓ 
ChemokineCCR1  K1787K1793✓ Ca²+(Fluo-4)
ChemokineCCR2  K1809 ✓ 
ChemokineCCR3  K1815 ✓ 
ChemokineCCR4  K1799 ✓ Ca²+(Fluo-4)
ChemokineCCR5  K1788 ✓Phospho-ERK2, Ca²+(Fluo-4)
ChemokineCCR6  K1761K1765✓ 
ChemokineCCR7  K1531  ✓Phospho-ERK2,
Ca²+(Fluo-4)
ChemokineCMKLR1  K1527 ✓ 
CholecystokininCCKAR  K1548K1623✓Ca²+(Fluo-4), Phospho-ERK2
CholecystokininCCKBR  K1742K1379✓Ca²+(Fluo-4)
Complement ComponentC5AR1  K1746K1554✓Ca²+(Fluo-4)
Corticotropin Releasing FactorCRHR1  K1736K1367✓cAMP
Corticotropin Releasing FactorCRHR2  K1733 ✓cAMP
DopamineD1  K1485  cAMP
DopamineD2  K1708 ✓Ca²+(Fluo-4),
Phospho-ERK2
DopamineD5  K1784  Ca²+(Fluo-4)
Endothelial Differentiation GeneEDG1  K1520 ✓ 
Endothelial Differentiation GeneEDG2  K1519 ✓ 
Endothelial Differentiation GeneEDG3  K1713K1319✓Ca²+(Fluo-4)
Endothelial Differentiation GeneEDG3  K1848  Ca²+(Fluo-4)
Endothelial Differentiation GeneEDG4  K1442 ✓ 
Endothelial Differentiation GeneEDG6  K1622BK1757✓ 
Endothelial Differentiation GeneEDG7  
K1511K1315✓Ca²+(Fluo-4)
Endothelial Differentiation GeneEDG7 
 K1849 ✓Ca²+(Fluo-4)
Endothelial Differentiation GeneEDG8  K1518 ✓ 
EndothelinEDNRA  K1726K1347✓Ca²+(Fluo-4)
EndothelinEDNRA  K1444 ✓ 
EndothelinEDNRB  K1727K1349✓Ca²+(Fluo-4)
Formyl Peptide-LikeFPRL-1  K1532K1357✓Ca²+(Fluo-4)
GalaninGALR1  K1616 ✓ 
GalaninGALR2  K1811 ✓ 
Gastrin Releasing PeptideGRPR  K1561K1637✓ 
GhrelinGHSR  K1819 ✓Ca²+(Fluo-4)
Gastric Inhibitory PolypeptideGIPR  K1864 ✓ 
GlucagonGCGR  K1855 ✓cAMP
GlucagonGLP1R  K1783 ✓cAMP
GlucagonGLP2R  K1543 ✓cAMP
Gonadotropin Releasing HormoneGnRHR  K1854 ✓Ca²+(Fluo-4)
HistamineH1  K1703K1299✓Ca²+(Fluo-4)
HistamineH2  K1707K1307✓cAMP
HistamineH3  K1466K1509✓ 
HistamineH4  K1465 ✓Ca²+(Fluo-4)
KiSS1GPR54  K1720K1333✓Ca²+(Fluo-4)
LeukotrieneLTB4R  K1748 ✓Ca²+(Fluo-4)
Melanin-concentrating HormoneMCHR1 (GPR24)  K1730 ✓Ca²+(Fluo-4)
Melanin-concentrating HormoneMCHR2 (GPR145)  K1852 ✓Ca²+(Fluo-4)
Melanin-concentrating HormoneMCHR2 (GPR145)  K1836 ✓Ca²+(Fluo-4),
Phospho-ERK2
MelanocortinMC1R  K1724 ✓cAMP
MelanocortinMC2R  K1483K1597✓ 
MelanocortinMC3R  K1744 ✓cAMP
MelanocortinMC5R  K1740 ✓cAMP
MelatoninMTNR1A  K1669 ✓ 
MelatoninMTNR1B  K1753 ✓ 
MotilinMLNR  K1862   
Neuropeptide B/WGPR8  K1478 ✓ 
Neuropeptide SNPSR1a  K1447K1493✓Ca²+(Fluo-4)
Neuropeptide SNPSR1b  K1481B ✓Ca²+(Fluo-4)
Neuromedin UNMUR1  K1719 ✓ 
NeurotensinNTSR1  K1781K1773✓Ca²+(Fluo-4)
Neuropeptide YNPY1R  K1803 ✓ 
Neuropeptide YNPY2R  K1479 ✓ 
Neuropeptide YNPY5R  K1782   
Nicotinic AcidGPR109A K1791 ✓ 
OpioidOPRD1  K1778 ✓ 
OpioidOPRM1  K1523K1599✓ 
OpioidOPRK1  K1533 ✓Ca²+(Fluo-4). Phospho-ERK2
OpioidOPRK1  K1576 ✓Phospho-ERK2
OpioidOPRL1  K1714 ✓Phospho-ERK2
OpioidOPRL1  K1786 ✓Ca²+(Fluo-4),
Phospho-ERK2
OrexinHCRTR1  K1446 ✓Ca²+(Fluo-4)
OrexinHCRTR2  K1737K1369✓Ca²+(Fluo-4)
Platelet Activating FactorPTAFR  K1789 ✓Ca²+(Fluo-4)
ProkineticinPROKR2 K1856   
Prolactin Releasing PeptideGPR10  K1732 ✓Ca²+(Fluo-4)
ProstanoidPTGDR  K1739K1373✓cAMP
ProstanoidCRTH2 (GPR44) K1859 ✓ 
ProstanoidPTGER1 K1851 ✓ 
ProstanoidPTGER2  K1723 ✓cAMP
ProstanoidPTGIR K1850 ✓ 
ProstanoidTBXA2R  K1549 ✓Ca²+(Fluo-4), Phospho-ERK2
Protease ActivatedF2RL1  K1830 ✓ 
P2Y (Purinergic/
Pyrimidinergic)		P2RY2  K1722K1337✓Ca²+(Fluo-4)
P2Y (Purinergic)P2RY4  K1863  Ca²+(Fluo-4)
P2Y (Purinergic)P2RY6  K1717K1327✓ 
P2Y (Purinergic)P2RY11  K1729 ✓Ca²+(Fluo-4)
P2Y (Purinergic)P2RY14  K1858   
RelaxinRLN3R1  K1569 ✓ 
SecretinSCTR  K1805 ✓ 
SerotoninHTR1A (5HT1A) K1857 ✓Phospho-ERK2
SerotoninHTR2B K1847 ✓ 
SerotoninHTR1D  K1524   
SerotoninHTR2A  K1562K1613✓ Ca²+(Fluo-4)
SerotoninHTR2C  K1877   Ca²+(Fluo-4)
SerotoninHTR2C      Ca²+(Fluo-4)
SerotoninHTR7  K1704 ✓ 
SomatostatinSSTR1  K1570 ✓ 
SomatostatinSSTR2  K1582 ✓ 
SomatostatinSSTR5  K1575 K1573✓ 
TachykininTACR1 K1801 ✓ 
TachykininTACR2 K1844 ✓Ca²+(Fluo-4), Phospho-ERK2
TachykininTACR3  K1603 ✓ 
Vasopressin & OxytocinAVPR1a  K1715K1323✓Ca²+(Fluo-4), Phospho-ERK2
Vasopressin & OxytocinAVPR2  K1718K1329✓cAMP
Vasopressin & OxytocinOXTR K1835 ✓ 
VIP & PACAPVPAC1  K1705 ✓cAMP
VIP & PACAPVPAC2  K1706 ✓cAMP
VIP & PACAPADCYAP1R1 (PAC1)  K1525K1619 ✓cAMP
OrphanGPR1 K1839  cAMP
OrphanGPR21 K1840   
OrphanGPR23 K1841   
OrphanGPR35  K1872 ✓ 
OrphanGPR39 K1842   
OrphanGPR119  K1486K163B1✓ 
OrphanGPR119  K1777K1770  
OrphanGPR120 (short) K1845   
OrphanGPR132 (G2A)  K1749   

For Research Use Only. Not for use in diagnostic procedures.