Obtain reliable analytical results. Remove sample uncertainty
Chromatographers use solid phase extraction (SPE) as a sample preparation method-of-choice to improve analytical results by removing interfering compounds, extracting the analyte in a preferred solvent, and concentrating the analyte. Thermo Scientific SPE sample preparation products address the differing sample extraction requirements required of industries including pharmaceutical, biotech, clinical research, environmental, forensics, and food safety.
Thermo Scientific HyperSep SPE products—a broad range of standard cartridges and well plates in a multitude of selectivity’s, sizes and formats.
Thermo Scientific SOLA & SOLAμ SPE products—an innovation that delivers highly reproducible extractions of low-volume, viscous, biological samples in high-throughput labs.
Thermo Scientific SPE cartridges and plates
Reversed phase non-polar (hydrophobic) SPE cartridges & well plates
Extraction accomplished by non-polar, non-polar interactions and Van der Waals or dispersion force
| Characteristics | Material | Typical applications |
|---|---|---|
| Polystyrene divinylbenzene material surface functionalized with pyrolidone |
|
SOLA & SOLAµ HRP SPE Cartridges and Well Plates
| Characteristics | Material | Typical applications |
|---|---|---|
A versatile polymeric material for the retention of polar and non-polar analytes
| Polystyrene divinylbenzene material surface modified with urea groups | Extraction of:
|
HyperSep Retain PEP SPE Cartridges
| Bed Weight (mg) | Column Volume (mL) | Retain PEP Cat No. | Quantity |
|---|---|---|---|
| 30 | 1 | 60107-201 | 100 Pack |
| 30 | 3 | 60107-202 | 50 Pack |
| 60 | 3 | 60107-203 | 50 Pack |
| 60 | 6 | 60107-208 | 30 Pack |
| 100 | 3 | 60107-217 | 50 Pack |
| 100 | 6 | 60107-207 | 30 Pack |
| 150 | 3 | 60107-209 | 30 Pack |
| 150 | 6 | 60107-211 | 30 Pack |
| 200 | 3 | 60107-204 | 50 Pack |
| 200 | 6 | 60107-212 | 30 Pack |
| 500 | 3 | 60107-205 | 50 Pack |
| 500 | 6 | 60107-206 | 30 Pack |
| 500 | 15 | 60107-219 | 20 Pack |
| 1,000 | 25 | 60107-215 | 20 Pack |
| 1,000 | 6 | 60107-218 | 30 Pack |
| 2,000 | 25 | 60107-214 | 20 Pack |
Note: For bed weights less than 30mg please refer to SOLA SPE products
Retain PEP 96 Well Plates
| Bed Weight (mg) | Well Volume (mL) | Retain PEP Cat No. | Format | Quantity |
|---|---|---|---|---|
| 30 | 1 | 60306-207 | Fixed | 1 Each |
| 60 | 1 | 60306-208 | Fixed | 1 Each |
| 30 | 1 | 60303-207 | Removable | 1 Each |
| 60 | 1 | 60303-208 | Removable | 1 Each |
Note: For bed weights less than 30mg please refer to SOLA SPE products
| Characteristics | Material | Typical applications |
|---|---|---|
For non-polar to moderately polar compounds
|
| Extraction of:
|
HyperSep C18 SPE Cartridges
| Bed Weight (mg) | Column Volume (mL) | Cat No. | Quantity |
|---|---|---|---|
| 25 | 1 | 60108-376 | 100 Pack |
| 50 | 1 | 60108-390 | 100 Pack |
| 100 | 1 | 60108-302 | 100 Pack |
| 100 | 3 | 60108-765 | 100 Pack |
| 200 | 3 | 60108-303 | 50 Pack |
| 500 | 3 | 60108-304 | 50 Pack |
| 500 | 6 | 60108-305 | 30 Pack |
| 500 | 10 | 60108-786 | 50 Pack |
| 1,000 | 6 | 60108-301 | 30 Pack |
| 1,000 | 15 | 60108-776 | 20 Pack |
| 2,000 | 15 | 60108-701 | 20 Pack |
| 2,000 | 25 | 60108-780 | 20 Pack |
| 5,000 | 25 | 60108-702 | 20 Pack |
| 10,000 | 75 | 60108-703 | 10 Pack |
| Characteristics | Material | Typical applications |
|---|---|---|
Less retentive alternative to C18 for non-polar to moderately polar compounds
|
| Extraction of:
|
| Characteristics | Material | Typical applications |
|---|---|---|
Alternative selectivity for retention of basic compounds
| A silica-based material which offers alternative selectivity for aromatic compounds due to the presence of the benzene ring within the structure. | Extraction of:
|
Mixed-mode—non-polar/ion exchange—SPE cartridges & well plates
Extraction accomplished using two functional groups: non-polar and ion exchange, which employs both hydrophobic and ionic retention. This phase is ideal for samples with complex structures.
| Characteristics | Material | Typical applications |
|---|---|---|
Polymeric material for the retention of weak acids
| Mixed mode Strong cation exchanger functionalized with quaternary groups Polystyrene divinylbenzene material surface functionalized with carboxylic acid |
|
| Characteristics | Material | Typical applications |
|---|---|---|
Polymeric material for the retention of weak bases
| Next generation Polystyrene divinylbenzene material surface functionalized with sulphonate groups |
|
| Characteristics | Material | Typical applications |
|---|---|---|
Polymeric material for the retention of strong acids
| Mixed mode weak anion exchanger Polystyrene divinylbenzene material surface functionalized with tertiary amine |
|
| Characteristics | Material | Typical applications |
|---|---|---|
Polymeric material for the retention of strong bases
| Mixed mode weak cation exchanger Polystyrene divinylbenzene material surface functionalized with carboxylic acid |
|
| Material | Characteristics | Typical applications |
|---|---|---|
A versatile polymeric material for the enhanced retention of basic compounds
| DVB material modified with sulfonic acid functional group for retention of basic | Analysis of a wide range of drugs of abuse including basic and neutral drugs from biological matrices. |
HyperSep Retain CX SPE Cartridges
| Bed Weight (mg) | Column Volume (mL) | Cat. No. | Quantity |
|---|---|---|---|
| 30 | 1 | 60107-301 | 100 Pack |
| 30 | 3 | 60107-302 | 50 Pack |
| 30 | 3 | 60107-303 | 50 Pack |
| 60 | 6 | 60107-308 | 30 Pack |
| 100 | 3 | 60107-317 | 50 Pack |
| 100 | 6 | 60107-307 | 30 Pack |
| 150 | 3 | 60107-309 | 30 Pack |
| 200 | 3 | 60107-311 | 30 Pack |
| 200 | 6 | 60107-304 | 50 Pack |
| 200 | 6 | 60107-314 | 30 Pack |
| 500 | 3 | 60107-305 | 50 Pack |
| 500 | 6 | 60107-306 | 30 Pack |
| 500 | 15 | 60107-319 | 20 Pack |
| 1,000 | 25 | 60107-315 | 20 Pack |
| 1,000 | 6 | 60107-318 | 30 Pack |
| 2,000 | 25 | 60107-312 | 20 Pack |
Note: For bed weights less than 30mg please refer to SOLA SPE products
HyperSep Retain CX 96 Fixed Well Plates
Note: For bed weights less than 30mg please refer to SOLA SPE products
| Material | Characteristics | Typical applications |
|---|---|---|
For retention of acidic compounds
| A versatile polymeric material for the enhanced retention of acidic compounds. | Analysis of a range of acidic drugs of abuse from biological matrices, such as THC and its metabolites. |
HyperSep Retain-AX SPE Cartridges
| Bed Weight (mg) | Column Volume (mL) | Retain AX | Quantity |
|---|---|---|---|
| 30 | 1 | 60107-401 | 100 Pack |
| 30 | 3 | 60107-402 | 50 Pack |
| 60 | 3 | 60107-403 | 50 Pack |
| 60 | 6 | 60107-408 | 30 Pack |
| 100 | 3 | 60107-417 | 50 Pack |
| 100 | 6 | 60107-407 | 30 Pack |
| 150 | 3 | 60107-413 | 30 Pack |
| 150 | 6 | 60107-411 | 30 Pack |
| 200 | 3 | 60107-404 | 50 Pack |
| 200 | 6 | 60107-412 | 30 Pack |
| 500 | 3 | 60107-405 | 50 Pack |
| 500 | 6 | 60107-406 | 30 Pack |
| 500 | 15 | 60107-419 | 20 Pack |
| 1,000 | 25 | 60107-415 | 20 Pack |
| 1,000 | 66 | 60107-418 | 30 Pack |
| 2,000 | 25 | 60107-414 | 20 Pack |
Note: For bed weights less than 30mg please refer to SOLA SPE products on page 1-011.
HyperSep Retain AX 96 Removable Well Plate
| Bed Weight (mg) | Volume (mL) | Retain CX Cat. No. | Quantity |
|---|---|---|---|
| 30 | 1 | 60303-407 | 1 Each |
| 60 | 1 | 60303-408 | 1 Each |
Note: For bed weights less than 30mg please refer to SOLA SPE products
Mixed-mode—normal phase/ion exchange—SPE cartridges & well plates
Phase accomplishes extraction using two functional groups: non-polar and ion exchange, which employs both hydrophobic and ionic retention. This mode deal for samples with complex structures
| Material | Characteristics | Typical applications |
|---|---|---|
Non-polar and anionic characteristics for improved analysis of basic drugs of abuse
| A mixed-mode material based on two functional groups bonded to the silica base: a reversed phase C8 group and a strong cation exchanger. |
|
| Material | Characteristics | Typical applications |
|---|---|---|
Non-polar and cationic characteristics for improved analysis of acidic drugs of abuse
| Verify-AX is a mixed-mode material based on two functional groups bonded to the silica base: a reversed phase C8 group and a strong anion exchanger. | Analysis of a range of acidic drugs of abuse from biological matrices, including THC and its metabolites. |
Ion exchange SPE cartridges & well plates
Extraction accomplished by electrostatic interactions
| Material | Characteristics | Typical applications |
|---|---|---|
For extraction of weak acids
| Ideal for the extraction of negatively charged compounds from both aqueous and non-aqueous matrices, as well as the extraction of weak acids such as carboxylic acid. | Removal of acidic food pigments, removal of phenolic compounds, nucleic acids, and surfactants. |
| Material | Characteristics | Typical applications |
|---|---|---|
For extraction of charged basic compounds
| Ideal for the extraction of positively charged compounds from both aqueous and non-aqueous matrices. | Extraction of:
|
Normal phase SPE cartridges & well plates
Extraction accomplished by polar-polar interactions and dipole-dipole interactions
| Material | Characteristics | Typical applications |
|---|---|---|
A polar sorbent primarily used to retain analytes from non-polar matrices
| Silica material is primarily used to extract analytes from non-polar solvents such as hydrocarbons, less polar esters and ethers. | Extraction of:
|
HyperSep Silica SPE Cartridges
| Bed Weight (mg) | Column Volume (mL) | Cat. No. | Quantity |
|---|---|---|---|
| 50 | 1 | 60108-409 | 100 Pack |
| 100 | 1 | 60108-317 | 100 Pack |
| 200 | 3 | 60108-410 | 50 Pack |
| 500 | 3 | 60108-315 | 50 Pack |
| 500 | 6 | 60108-411 | 30 Pack |
| 500 | 10 | 60108-793 | 50 Pack |
| 1,000 | 6 | 60108-426 | 30 Pack |
| 2,000 | 15 | 60108-710 | 20 Pack |
| 5,000 | 25 | 60108-711 | 20 Pack |
| 10,000 | 25 | 60108-853 | 20 Pack |
| 10,000 | 75 | 60108-712 | 10 Pack |
| 50,000 | 150 | 60108-850 | 10 Pack |
| 20,000 | 75 | 60108-851 | 10 Pack |
| 70,000 | 150 | 60108-852 | 10 Pack |
| 1,000 | 3 mL | 60108-441 | Unknown |
| 100 mg | 10 mL | 60108-503 | 50 Pack |
| Material | Characteristics | Typical applications |
|---|---|---|
Ideal for the isolation of polar compounds from non-polar matrices
| Florisil is a magnesia-loaded silica gel | Extraction of:
|
HyperSep Florisil 96 Fixed/Removable Well Plates
| Bed Weight (mg) | Column Volume (mL) | Fixed Cat. No. | Removable Cat. No. | Quantity |
|---|---|---|---|---|
| 10 | 1 | 60307-281 | 60300-725 | 1 Each |
| 25 | 1 | 60307-282 | 60300-726 | 1 Each |
| 50 | 1 | 60307-283 | 60300-727 | 1 Each |
| 100 | 1 | 60307-284 | 60300-728 | 1 Each |
| Characteristics | Material | Typical applications |
|---|---|---|
For retention of polar compounds from non-polar matrices
|
|
|
| Characteristics | Material | Typical applications |
|---|---|---|
| A silica-based material | Normal phase extraction and purification of polar compounds |
| Characteristics | Material | Typical applications |
|---|---|---|
A polar sorbent for both polar and anion exchange interactions
| A silica-based material which can be used as both a polar sorbent and a weak anion exchanger. | Extraction of
|
| Material | Characteristics | Typical applications |
|---|---|---|
Unique material for retention of highly polar compounds
|
| Ideal for problem analytes in SPE applications. |
SPE selector chart
High-throughput SPE. Low-volume samples. Great extraction!
For bioanalysis applications, use SOLA & SOLAμ SPE Cartridges and Plates. This latest innovation in SPE addresses the extraction requirements you need for fast, efficient extraction of biological samples.
New to SPE? Watch this video to see a benchtop demonstration of the SPE workflow. This example uses the HyperSep Verify CX SPE cartridge to extract compounds from urine for subsequent gas chromatography analysis.
Ultimate guide to solid phase extraction
This 144-page guide includes:
| What you need to know about: | Methods for: |
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Resources
Learn more about SPE
CMD SchemaApp code