Table 18.2 Scavengers of reactive oxygen species (ROS).
| ROS | Scavenger (Working Concentration) | References |
|---|---|---|
| Hydrogen peroxide (H2O2) | Sodium pyruvate (10 mM), DMTU * (10 mM) |  |
| Hydroxyl radical (HO•) | Mannitol (20–100 mM), DMSO (0.28 M) † | |
| Nitric oxide (NO) | Carboxy-PTIO (C7912; 100 µM) | |
| Peroxyl radical (ROO•) | Trolox ‡ (10–100 µM), α-tocopherol (10–100 µM) | |
| Peroxynitrite anion (ONOO–) | Ebselen § (10–100 µM), uric acid (100 µM) | |
| Singlet oxygen (1O2) | Sodium azide (1–10 mM) | |
| Superoxide anion (•O2–) | MnTBAP ** (100 µM), Tiron †† (10 mM) | |
| * DMTU = N,N'-dimethylthiourea. Disproportionation by catalase is also widely used for suppression of H2O2. † 0.28 M DMSO = 2% (v/v). The reactivity of OH• is so high that it can be argued that the actions of these reagents must be indirect. ‡ Trolox = 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid. § Ebselen = 2-phenyl-1,2-benzisoselenazol-3(2H)-one. ** MnTBAP = manganese(III)-tetrakis(4-benzoic acid)porphyrin. †† Tiron = 4,5-dihydroxybenzene-1,3-disulfonate. | ||
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