In vitro assays and screening technologies
At Life Technologies we have developed two pre-configured fluorescent assay solutions to address HTS, hit confirmation and lead optimization programs for nuclear receptor targets.
The core assay formats we have developed are:
- NR Competitive Binding Assays
- NR Coactivator Assays
View the table below for a complete list of the biochemical assays offered for your nuclear receptor research.
If you do not see the target or assay format of your choice please contact us.
Nuclear Receptor Biochemical Assay Selection Table
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| Target | Alias(es) | Accession number | PolarScreen™ Nuclear Receptor Competitor Assay (Fluorescent Polarization) | LanthaScreen® Competitive Binding Assay (TR-FRET)* | LanthaScreen® Coactivator Assay (TR-FRET)* |
|---|---|---|---|---|---|
| Androgen receptor | AR, NR3C4 | NP_036634 | A15878 | ||
| Constitutive androstane receptor | CAR, NR1I3 | NP_005113.1 | PV4836 | ||
| Estrogen receptor alpha | ER Alpha, ERA, ESR1, NR3A1 | NP_000116.2 | A15887 | A15885 | |
| Estrogen receptor beta | ER Beta, ERB, ESR2, NR3A2 | NP_001428.1 | A15895 | A15893 | |
| Estrogen-related receptor alpha | ERR Alpha, ERR1, ESRRA, ESRL1, NR3B1 | NP_004442.2 | PV4663 | ||
| Estrogen-related receptor beta | ERR Beta, ERR2,ESRRB, NR3B2 | NP_004443.2 | PV4800 | ||
| Estrogen-related receptor gamma | ERR Gamma, ERR3, ESRRG, NR3B3 | NP_001429 | PV4408 | ||
| Farnesoid X receptor | FXR,NR1H4 | NP_005114.1 | PV4833 | ||
| Glucocorticoid receptor | GR, GCCR, GCR, NR3C1 | NP_000167 | A15901 | A15899 | |
| Liver X receptor alpha | LXR Alpha, LXRA, NR1H3 | NP_005684 | PV4655 | ||
| Liver X receptor beta | LXR Beta, LXRB, NR1H2 | NP_009052 | PV4658 | ||
| Peroxisome proliferator-activated receptor alpha | PPAR Alpha, PPARA, NR1C1 | NP_005027 | PV4892 | PV4684 | |
| Peroxisome proliferator-activated receptor delta | PPAR Delta, PPARD, NR1C2 | NP_006229 | PV4893 | PV4685 | |
| Peroxisome proliferator-activated receptor gamma | PPAR Gamma, PPARG, NR1C3 | NP_005028 | PV6136 -Green | PV4894 | PV4548 |
| Pregnane X receptor | PXR(SXR), NR1I2 | NP_003880.3 | PV4839 | ||
| Progesterone receptor | PR, PGR, NR3C3 | NP_000917.2 | A15903 | ||
| Retinoic acid receptor alpha | RAR Alpha, RARA, NR1B1 | NP_000955 | PV4409 | ||
| Retinoic acid receptor beta | RAR Beta, RARB, NR1B2 | NP_000956 | PV4688 | ||
| Retinoic acid receptor gamma | RAR Gamma, RARG,NR1B3 | NP_000957 | PV4411 | ||
| Retinoid-related Orphan Receptor alpha | ROR Alpha, RORA, NR1F1 | NP_599023.1 | PV5889 | ||
| Retinoid X receptor alpha | RXR Alpha, RXRA, NR2B1 | NP_002948.1 | PV4797 | ||
| Retinoid X receptor beta | RXR Beta, RXRB, NR2B2 | NP_068811 | PV4385 | ||
| Thyroid receptor alpha | TR Alpha, THRA, NR1A1 | NP_955366.1 | PV4687 | ||
| Thyroid receptor beta | TR Beta, THRB, T3RB, NR1A2 | NP_000452.2 | PV4686 | ||
| Vitamin D3 receptor | VDR, NR1I1 | NP_000367 | PV4554 |
* Other LanthaScreen® Fluorescent Coregulator Peptides are available for your development of additional coactivator or corepressor assays.
For Research Use Only. Not for use in diagnostic procedures.