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Discover available B·R·A·H·M·S Biomarker Assays

Thermo Scientific B·R·A·H·M·S Biomarkers provide an outstanding long-term lot-to-lot stability and highest precision for the most reliable results in prenatal screening.1 With our biomarker portfolio, we provide solutions from first trimester trisomy to second trimester trisomy and neural tube defect screening.


B·R·A·H·M·S AFP KRYPTOR

Intended uses

First trimester screening/risk assessment Second trimester screening/risk asessment Second trimester diagnosis
Trisomy 21 Trisomy 21 Trisomy 18 NTD* in serum and plasma (heparin) NTD* in amniotic fluid

* Neural Tube Defect

US Only: Product is not FDA cleared in US.

 

Product specifications

Sample volume 14 µL
Sample type Serum, heparin plasma, amniotic fluid
Incubation time 9 min
Linear direct measuring range 1.91 to 700 ng/mL
Upper measuring range with automatic dilution up to 500 000 ng/mL
Limit of detection 0.21 ng/mL
Limit of quantification 1.91 ng/mL
Kit stability on board 15 days
Calibrator 1 point
Calibration stability 15 days

B·R·A·H·M·S AFP KRYPTOR kit and accessories

Article number Description
816075N B·R·A·H·M·S AFP KRYPTOR
Kit, reagents for 75 determinations
081691N B·R·A·H·M·S AFP KRYPTOR CAL
Calibrator kit, 6 vials
081693N B·R·A·H·M·S AFP KRYPTOR Diluent
Diluent AFP for amniotic fluid samples, 5 vials
088192N B·R·A·H·M·S GM KRYPTOR QC
Control kit prenatal screening, 3 levels (2 vials per level)

B·R·A·H·M·S Free βhCG KRYPTOR

Intended uses

First trimester screening Second trimester screening
Trisomy 21 Trisomy 18 Trisomy 13 Trisomy 21
Trisomy 18

US Only: Product is not FDA cleared in US.

 

Product specifications

Sample volume 26 µL
Sample type Serum
Incubation time 19 min
Linear direct measuring range 0.74 to 150 IU/L
Upper measuring range with automatic dilution up to 50 000 IU/L
Limit of detection 0.09 IU/L
Limit of quantification 0.74 IU/L
Kit stability on board 29 days
Calibrator 1 point
Calibration stability 15 days

B·R·A·H·M·S Free βhCG KRYPTOR kit and accessories

Article number Description
809075N B·R·A·H·M·S Free βhCG KRYPTOR
Kit, reagents for 75 determinations
080991N B·R·A·H·M·S Free βhCG KRYPTOR CAL
Calibrator kit, 6 vials
088192N B·R·A·H·M·S GM KRYPTOR QC
Control kit prenatal screening, 3 levels (2 vials per level)

B·R·A·H·M·S hCG+β KRYPTOR

Intended uses

Second trimester screening
Trisomy 21 Trisomy 18 

US Only: Product is not FDA cleared in US.

 

Product specifications

Sample volume 26 µL
Sample type Serum
Incubation time 14 min
Linear direct measuring range 5.0 to 2 000 IU/L
Upper measuring range with automatic dilution up to 1 000 000 IU/L
Limit of detection 2.0 IU/L
Limit of quantification 5 IU/L
Kit stability on board 29 days
Calibrator 1 point
Calibration stability 15 days

B·R·A·H·M·S hCG+β KRYPTOR kit and accessories

Article number Description
841050N B·R·A·H·M·S hCG+β KRYPTOR
Kit, reagents for 50 determinations
084191N B·R·A·H·M·S hCG+β KRYPTOR CAL
Calibrator kit, 6 vials
084192N B·R·A·H·M·S hCG+β KRYPTOR QC
Control kit, 2 levels (3 vials per level)

B·R·A·H·M·S Inhibin A KRYPTOR

Intended uses

Second trimester screening
Trisomy 21  

US Only: Product is not FDA cleared in US.

 

Product specifications

Sample volume 70 µL
Sample type Serum
Incubation time 39 min
Linear direct measuring range 53.3 to 5000 pg/mL
Limit of detection 20.9 pg/mL
Limit of quantification 53.3 pg/mL
Kit stability on board 15 days
Calibrator 1 point
Calibration stability 7 days

B·R·A·H·M·S Inhibin A KRYPTOR kit and accessories

Article number Description
850075N B·R·A·H·M·S Inhibin A KRYPTOR
Kit, reagents for 75 determinations
085091N B·R·A·H·M·S Inhibin A KRYPTOR CAL
Calibrator kit, 6 vials
085092N B·R·A·H·M·S Inhibin A KRYPTOR QC
Control kit, 3 levels (2 vials per level)

B·R·A·H·M·S PAPP-A KRYPTOR

Intended uses

First trimester screening/risk assessment
Trisomy 21  
Trisomy 18 Trisomy 13

US Only: Product is not FDA cleared in US.

 

Product specifications

Sample volume 50 µL
Sample type Serum
Incubation time 19 min
Linear direct measuring range 0.010 to 6 IU/L
Upper measuring range with automatic dilution up to 90 IU/L
Limit of detection 0.0054 IU/L
Limit of quantification 0.01 IU/L
Kit stability on board 29 days
Calibrator 1 point
Calibration stability 15 days

B·R·A·H·M·S PAPP-A KRYPTOR kit and accessories

Article number Description
866075N B·R·A·H·M·S PAPP-A KRYPTOR
Kit, reagents for 75 determinations
086691N B·R·A·H·M·S PAPP-A KRYPTOR CAL
Calibrator kit, 6 vials
088192N B·R·A·H·M·S GM KRYPTOR QC
Control kit prenatal screening, 3 levels (2 vials per level)

B·R·A·H·M·S PlGF plus KRYPTOR

Intended uses

First trimester screening/risk assessment
Trisomy 21  

US Only: Product is not FDA cleared in US.

 

Product specifications

Sample volume 70 µL
Sample type Serum, EDTA plasma
Incubation time 29 min
Linear direct measuring range 7.7 to 7 000 pg/mL
Limit of detection 4.91 pg/mL
Limit of quantification 7.7 pg/mL
Kit stability on board 29 days
Calibrator 1 point
Calibration stability 15 days

B·R·A·H·M·S PlGF plus KRYPTOR kit and accessories

Article number Description
859075N B·R·A·H·M·S PlGF plus KRYPTOR
Kit, reagents for 75 determinations
085991N B·R·A·H·M·S PlGF plus KRYPTOR CAL
Calibrator kit, 6 vials
085992N B·R·A·H·M·S PlGF plus KRYPTOR QC
Control kit, 3 levels (2 vials per level)

B·R·A·H·M·S uE3 KRYPTOR

Intended uses

Second trimester screening
Trisomy 21  

US Only: Product is not FDA cleared in US.

 

Product specifications

Sample volume 50 µL
Sample type Serum
Incubation time 19 min
Linear direct measuring range 0.52 to 17 nmol/L
Limit of detection 0.2 nmol/L
Limit of quantification 0.52 nmol/L
Kit stability on board 15 days
Calibrator 2 point
Calibration stability 7 days

B·R·A·H·M·S uE3 KRYPTOR kit and accessories

Article number Description
803075N B·R·A·H·M·S uE3 KRYPTOR
Kit, reagents for 75 determinations
080391N B·R·A·H·M·S uE3 KRYPTOR CAL
Calibrator kit, 6 vials (2 levels)
080392N B·R·A·H·M·S uE3 KRYPTOR QC
Control kit, 3 levels (2 vials per level)

Pre-eclampsia management

B·R·A·H·M·S Biomarkers for pre-eclampsia management are also available. Improve laboratory precision and patient management.

Discover our CE marked, FMF approved, and FDA cleared solutions for pre-eclampsia.


References

1.     Monthly UK NEQAS reports, February 2003 - December 2023.

Thermo Fisher Scientific products are distributed globally and their uses, applications, indications, claims and availability of products in each country depend on local regulatory marketing authorization status, please consult the Instructions For Use (IFU) available in your country.

 

© 2024 Thermo Fisher Scientific Inc. All rights reserved. All trademarks are the property of Thermo Fisher Scientific and its subsidiaries unless otherwise specified. B·R·A·H·M·S is a registered trademark of B·R·A·H·M·S GmbH.

 

KRYPTOR and TRACE are trademarks of Cisbio Bioassays, licensed for use by B·R·A·H·M·S GmbH, a part of Thermo Fisher Scientific. Nobel Prize is a registered trademark of the Nobel Foundation.

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