Prenatal screening software: B·R·A·H·M·S Fast Screen pre I plus Software for aneuploidy and neural tube defects
Discover our modern, powerful and robust clinical prenatal screening software for trisomies and neural tube defects (NTDs) in the first and/or second trimester.
Thermo Scientific B·R·A·H·M·S Fast Screen pre I plus Software is a CE marked prenatal screening software designed to ensure convenience of data entry, risk calculation and reporting for laboratories with both low and high data throughput. It is designed to be used with Thermo Scientific B·R·A·H·M·S KRYPTOR Instruments and Assays.
Key features
First trimester trisomy screening algorithms
B·R·A·H·M·S Fast Screen pre I plus software comprises first trimester algorithms for trisomy that are based on the Fetal Medicine Foundation UK (FMF) data and are updated with recently published correction factors. In addition, our software also includes the algorithm from the FMF Germany.
| Trisomies 21, 18 and 13 | |
| Time range |
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| Biomarkers |
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| Physical markers |
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The medians of the B·R·A·H·M·S biochemical markers free βhCG, PAPP-A and PlGF which are included in our software are extremely stable. These medians were established on over 220,000 healthy pregnancies which ensures reproducibility and robustness of the risk calculation.1,2 Therefore, a recalculation of the medians and MoMs over time is not required.
FMF first trimester combined test performances for fetal trisomies
View the FMF first trimester combined test performances for fetal trisomies below.3
| Risk cut-off | Detection rate | False positive rate | |
| Trisomy 21 (Down’s syndrome) |
1:100 | 91.2% | 4.6% |
| Trisomy 18 (Edwards' syndrome) |
1:50 | 94.6% | 2.7% |
| Trisomy 13 (Patau's syndrome) |
1:50 | 87.5% | 2.7% |
Second trimester trisomy and neural tube defect (NTD) screening
The B·R·A·H·M·S Fast Screen pre I plus second trimester algorithm allows calculation of risk for trisomies 21 and 18 with double test (AFP in combination with free βhCG or total hCG) between 14+0 and 19+6.
Between 15+0 and 19+6, the AFP concentration can be used as a marker of fetal NTD.
More than just a risk calculation tool for your trisomy and NTD screening
Simple and user-friendly interface available in six languages
Available in English, German, French, Spanish, Italian, and Turkish
References
- Concerning free βhCG and PAPP-A medians please refer to D. Wright et al., “First-trimester combined screening for trisomy 21 at 7-14 weeks’ gestation” Ultrasound Obstet. Gynecol., vol. 36, no. 4, pp. 404–411, 2010.
- Concerning PlGF medians please refer to P. Pandya et al., “Maternal serum placental growth factor in prospective screening for aneuploidies at 8-13 weeks’ gestation” Fetal Diagn. Ther., vol. 31, no. 2, pp. 87–93, 2012.
- M. Santorum, D. Wright, A. Syngelaki, N. Karagioti, and K. H. Nicolaides, “Accuracy of first-trimester combined test in screening for trisomies 21, 18 and 13” Ultrasound Obstet. Gynecol., vol. 49, no. 6, pp. 714–720, Jun. 2017.
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