Making the undetectable, detectable
Improve separation and detectability of a compound destined for GC or GC-MS analysis using this selection of derivatization reagents. We also offer siliconizing fluids to coat various lab consumables with an inert, water-repellent film. All Thermo Scientific GC reagents offer the variety, quality and reliability you need.
Popular gas chromatography derivatization reagents
GC reagents
Silylation Reagents | |
|---|---|
| The most widely used derivatives for GC applications | |
| BSTFA and BSTFA + TMCS | For excellent separations and difficult-to-silylate compounds. |
| MSTFA and MSTFA + 1% TMCS | Offers maximum volatility. Ideal for preparing volatile and thermally stable derivatives for GC and GC-MS. |
| BSA | The perfect reagent for rapid silylation reactions. Ideal for alcohols, amines, amides, carboxylic acids, phenols, steroids, biogenic amines and alkaloids. |
| MTBSTFA and MTBSTFA + 1% TBDMCS Silylation Reagent | Offers stable TBDMS (tert-butyldimethylsilyl) derivatization of hydroxyl, carboxyl, thiol and primary and secondary amines with typical yields over 96%. |
| TMSI (N-Trimethylsilylimisazole) | The strongest silylator for carbohydrates and steroids Reacts quickly and smoothly with hydroxyls and carboxylic acids, but not with amines. |
| HMDS (Hexamethyldisilazane) | The popular choice for silylation of sugars and related substances to extend the practical range of GC and improve chromatographic results. |
| MOX (Methoxamine) | Useful for preparing oximes of steroids and ketoacids prior to silylation |
| Tri-Sil HTP (HMDS:TMCS:Pyridine) | Reagent-catalyst mixture for one-step derivatization of carbohydrates, phenols, steroids, sterols, organic acids, alcohols and some amines |
| Tri-Sil BP (BSA:Pyridine) | Derivatizes alcohols, phenols, organic acids, aromatic amides and amines |
| Tri-Sil TBT (TMSI:BSA:TMCS) | A catalyzed silylation reagent formulation containing three parts TMSI, three parts BSA and two parts TMCS |
| Tri-Sil TP (TMSI:Pyridine) | Derivatizes hydroxyl compounds, particularly carbohydrates |
| TMCS (Trimethylchlorosilane) | An excellent catalyst for difficult-to-silylate compounds. Excellent adjunct for forming trimethylsilyl ethers for GC determinations. |
| Silylation Grade Solvents | Manufactured for the exacting needs of silylation and other sensitive derivatization reactions. |
Acylation Reagents | |
|---|---|
| Converts compounds that contain active hydrogens through the action of a carboxylic acid or a carboxylic acid derivative | |
| Pentafluoropropanol | Purified for GC-MS applications, The addition of fluorine greatly enhances the sensitivity of certain detectors. |
| MBTFA (N-Methyl-bis(trifluoroacetamide) | For trifluoroacylating primary and secondary amines, hydroxyl and thiol groups and carbohydrates. |
| Perfluoroacylimidazoles (HFBI and TFAI) | Offer effective acylation of hydroxyl groups and primary and secondary amines. |
| Perfluoro Acid Anhydrides (TFAA, PFAA and HFAA) | Highly purified for optimal preparation of fluoracyl derivatives. |
Alkylation Reagents | |
|---|---|
| Substitution of an active hydrogen by an aliphatic or aliphatic-aromatic (benzyl) group for modifying compounds containing acidic hydrogens, such as carboxylic acids and phenols. | |
| BF3-Methanol | Provides convenient, fast and quantitative esterification of fatty acids. |
| Pentafluorobenzyl Bromide (PFBBr) | For electron capture GC analysis of carboxyl acids, phenols and sulfonamides. |
| Methylate (DMFDMA) | For easy, effective preparation of methyl esters from fatty acids and amino acids. |
| MethElute (TMPAH) Alylation Reagent | Provides accurate sensitive on-column methylation. |
Siliconizing Fluids | |
|---|---|
| Coat various lab consumables with an inert, water-repellent film. | |
| Water-Soluble Siliconizing Fluid | Attaches the silane polymer, octadecyltrialkosilane, to make the surface inert or polymerizes to create an inert film. |
| Hydrocarbon-Soluble Siliconizing Fluid | Attaches a short-chain silane polymer to make the surface inert or polymerizes to create an inert film. |
Silylation Reagents | |
|---|---|
| The most widely used derivatives for GC applications | |
| BSTFA and BSTFA + TMCS | For excellent separations and difficult-to-silylate compounds. |
| MSTFA and MSTFA + 1% TMCS | Offers maximum volatility. Ideal for preparing volatile and thermally stable derivatives for GC and GC-MS. |
| BSA | The perfect reagent for rapid silylation reactions. Ideal for alcohols, amines, amides, carboxylic acids, phenols, steroids, biogenic amines and alkaloids. |
| MTBSTFA and MTBSTFA + 1% TBDMCS Silylation Reagent | Offers stable TBDMS (tert-butyldimethylsilyl) derivatization of hydroxyl, carboxyl, thiol and primary and secondary amines with typical yields over 96%. |
| TMSI (N-Trimethylsilylimisazole) | The strongest silylator for carbohydrates and steroids Reacts quickly and smoothly with hydroxyls and carboxylic acids, but not with amines. |
| HMDS (Hexamethyldisilazane) | The popular choice for silylation of sugars and related substances to extend the practical range of GC and improve chromatographic results. |
| MOX (Methoxamine) | Useful for preparing oximes of steroids and ketoacids prior to silylation |
| Tri-Sil HTP (HMDS:TMCS:Pyridine) | Reagent-catalyst mixture for one-step derivatization of carbohydrates, phenols, steroids, sterols, organic acids, alcohols and some amines |
| Tri-Sil BP (BSA:Pyridine) | Derivatizes alcohols, phenols, organic acids, aromatic amides and amines |
| Tri-Sil TBT (TMSI:BSA:TMCS) | A catalyzed silylation reagent formulation containing three parts TMSI, three parts BSA and two parts TMCS |
| Tri-Sil TP (TMSI:Pyridine) | Derivatizes hydroxyl compounds, particularly carbohydrates |
| TMCS (Trimethylchlorosilane) | An excellent catalyst for difficult-to-silylate compounds. Excellent adjunct for forming trimethylsilyl ethers for GC determinations. |
| Silylation Grade Solvents | Manufactured for the exacting needs of silylation and other sensitive derivatization reactions. |
Acylation Reagents | |
|---|---|
| Converts compounds that contain active hydrogens through the action of a carboxylic acid or a carboxylic acid derivative | |
| Pentafluoropropanol | Purified for GC-MS applications, The addition of fluorine greatly enhances the sensitivity of certain detectors. |
| MBTFA (N-Methyl-bis(trifluoroacetamide) | For trifluoroacylating primary and secondary amines, hydroxyl and thiol groups and carbohydrates. |
| Perfluoroacylimidazoles (HFBI and TFAI) | Offer effective acylation of hydroxyl groups and primary and secondary amines. |
| Perfluoro Acid Anhydrides (TFAA, PFAA and HFAA) | Highly purified for optimal preparation of fluoracyl derivatives. |
Alkylation Reagents | |
|---|---|
| Substitution of an active hydrogen by an aliphatic or aliphatic-aromatic (benzyl) group for modifying compounds containing acidic hydrogens, such as carboxylic acids and phenols. | |
| BF3-Methanol | Provides convenient, fast and quantitative esterification of fatty acids. |
| Pentafluorobenzyl Bromide (PFBBr) | For electron capture GC analysis of carboxyl acids, phenols and sulfonamides. |
| Methylate (DMFDMA) | For easy, effective preparation of methyl esters from fatty acids and amino acids. |
| MethElute (TMPAH) Alylation Reagent | Provides accurate sensitive on-column methylation. |
Siliconizing Fluids | |
|---|---|
| Coat various lab consumables with an inert, water-repellent film. | |
| Water-Soluble Siliconizing Fluid | Attaches the silane polymer, octadecyltrialkosilane, to make the surface inert or polymerizes to create an inert film. |
| Hydrocarbon-Soluble Siliconizing Fluid | Attaches a short-chain silane polymer to make the surface inert or polymerizes to create an inert film. |
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