Highlights
Achieve the highest confidence in targeted compound detection and quantitation through leading sensitivity
Greater than 6 orders of linear dynamic range with high selectivity. Enhanced acquisition speeds empower large-scale studies for translational workflow development or method optimization with effective dwell time settings as low as 0.3 milliseconds — 5 millisecond polarity switching maximizes productivity in fewer experiments.
Where data confidence is required, the instrumental features on the TSQ Altis Plus triple quadrupole mass spectrometer drive high-performance targeted experiments for complex matrices.
High-throughput screening and quantitation
Innovations in the ion source, mass analyzer, active Q2 collision cell, and RF electronics offer high sensitivity, selectivity, and superior acquisition speeds/polarity switching times that are ideal with ultra-high performance liquid chromatography (UHPLC) separations. With scheduled SRM acquisition and 600 SRMs/second, 1000’s of compounds can be screened or quantified per method. Fast data acquisition reaches the number of required data points for outstanding confidence at extremely low concentrations, in the most challenging matrices.
Expanded experimental capabilities
Integrated workflow solutions centered on the TSQ Altis Plus mass spectrometer address regulated requirements targeting a growing list of diverse compounds. New UHPLC and ion chromatography (IC) systems maximize sample delivery and separation capabilities, maintaining the sensitivity to meet minimum residue limits without costly sample preparation or derivatization steps. Thermo Scientific Chromeleon Chromatographic Data System (CDS) software controls all experimental attributes in a regulated environment to further drive productivity.
Operational simplicity
Targeted research and routine applications demand fast and responsive instrument control software, with intuitive operations. Simplified calibration approach consolidates steps needed by the operator, combining an intelligent instrument check and calibration routine. Direct method transfer from the previous generation Thermo Scientific TSQ mass spectrometers can be performed for equal or better performance without optimization.
Experimental determination of dwell times assigned to each transition has been automated based on user-defined chromatographic peak width and the option of fixed cycle time or optimal number of data points per chromatographic peak. Prioritization settings allow further adjustments.
Database integration
Method development for targeted acquisition methods requires a prior knowledge of optimal product ions and energetics. Utilization of experimental libraries created from discovery experiments can by-pass the need for purified standards and lengthy optimization routines. The output from processed data in Thermo Scientific TraceFinder software can be directly imported into the instrument method editor, streamlining large-scale study creation.
Discovery experiments, however, may not contain all compounds targeted in a study. Integration with Thermo Scientific mzCloud databases enables selection of additional compounds from the most advanced mass spectral database to be added into existing experimental methods.
Webinars & videos
Meet the TSQ Plus triple quadrupole mass spectrometers
Learn about the new hardware features driving next-level performance for targeted quantitation.
40th Anniversary of Thermo Scientific Triple Quadrupole Mass Spectrometers
See how Thermo Scientific has been enabling labs to meet their quantitation challenges for over 40 years.
Overcoming the challenges of anti-sports doping
Watch Dr. Ludovic Bailly-Chouriberry, Laboratory Director, discuss how the TSQ Altis Plus mass spectrometer increases productivity for anti-sports doping.
Improving biotherapeutic PK studies
JUN QU, PhD. of SUNY Buffalo discusses improving the limit of quantitation for protein therapeutics using the TSQ Altis Plus mass spectrometer and FAIMS Pro Duo interface.
Ideal solution for routine peptide quantitation
University of Washington Professor Michael MacCoss highlights the TSQ Altis Plus mass spectrometer delivering targeted protein methods and workflow solutions.
Routine omics-scale lipid profiling
Learn how Dr. Julijana Ivanisevic of the University of Lausanne uses large-scale lipid analysis for populational screening.
Meet the TSQ Plus triple quadrupole mass spectrometers
Learn about the new hardware features driving next-level performance for targeted quantitation.
40th Anniversary of Thermo Scientific Triple Quadrupole Mass Spectrometers
See how Thermo Scientific has been enabling labs to meet their quantitation challenges for over 40 years.
Overcoming the challenges of anti-sports doping
Watch Dr. Ludovic Bailly-Chouriberry, Laboratory Director, discuss how the TSQ Altis Plus mass spectrometer increases productivity for anti-sports doping.
Improving biotherapeutic PK studies
JUN QU, PhD. of SUNY Buffalo discusses improving the limit of quantitation for protein therapeutics using the TSQ Altis Plus mass spectrometer and FAIMS Pro Duo interface.
Ideal solution for routine peptide quantitation
University of Washington Professor Michael MacCoss highlights the TSQ Altis Plus mass spectrometer delivering targeted protein methods and workflow solutions.
Routine omics-scale lipid profiling
Learn how Dr. Julijana Ivanisevic of the University of Lausanne uses large-scale lipid analysis for populational screening.
Resources
To perform quantitation assays with confidence, you need a liquid chromatography mass spectrometry (LC-MS) workflow solution that is relevant to your goals
Poster: Development of small molecule system suitability standard for routine monitoring of LC-MS
Learn how Thermo Fisher Scientific has introduced a commercially available small molecule system suitability kit that provides comprehensive LC-MS/MS performance evaluation.
Poster: Small molecule system suitability test for LC-MS/MS
ASMS poster introducing simple set of experiments used to enable evaluation of key instrument performance over time or across instruments.
White Paper: Sensitivity and acquisition speed with triple quadrupole technology
Today’s analytical methods performing routine quantitation continue to evolve to meet new environmental and health risks. Experimental methods are modified to include more compounds measured at lower detection levels with faster gradients to address throughput. Therefore, specific LC-MS/MS performance characteristics are critical to evaluate productivity.
White Paper: Triple quadrupole mass spectrometer portfolio
Learn about the hardware and software innovations implemented in the TSQ triple quadrupole mass spectrometer platform to address the current and future challenges in targeted quantitation. The platform enhancements enable ultimate confidence in data quality with robust, reproducible, and reliable quantitative methodologies.
Application Note: Sensitive LC-MS/MS quantitation of antisense oligonucleotides in plasma using the TSQ Altis Plus mass spectrometer
Sensitive and reproducible quantitation of ASOs with human plasma matrix by IPRP-LC-MS/MS using the Thermo Scientific™ TSQ Altis™ Plus mass spectrometer coupled to the Thermo Scientific™ Vanquish™ Horizon UHPLC system.
White Paper: A guide to implementing targeted and standardized clinical metabolomics using stable isotope-labeled standards and triple quadrupole mass spectrometry.
Learn the key experimental steps needed to develop and standardize targeted metabolite quantitation for clinical research using the TSQ Altis and Altis Plus mass spectrometer.
Application Note: Highly sensitive method for the determination of 12 nitrosamine impurities in multiple ARBs, the class of sartan drug formulations
Single method applicable for highly sensitive quantitation of 12 nitrosamines in three ARB drug substances.
Workflows and instruments for reliable PFAS analysis
As knowledge about per- and polyfluoroalkyl substances (PFAS) grows, detecting these chemicals in environmental samples has become critical. PFAS contamination, often in the form of PFOA or PFOS, can be determined by one of several US EPA PFAS methods including Methods 533 and 537 for the determination of PFAS in drinking water and OTM-45 to test for PFAS in air emissions.
As we identify chemicals that pose environmental and health risks, it is critical to find effective and responsive solutions for routine quantitation to address current and emerging regulations. Your quantitative solutions must address a wide range of analytical requirements to screen and quantitate low-level chemical contaminants. These compounds and methods are diverse, requiring integrated solutions to respond quickly and confidently while meeting regulations.
Direct analysis of selected per- and polyfluorinated alkyl substances (PFAS) in ground, surface, and waste water by LC-MS/MS
Validation of a robust method with trace level quantitation of polar compounds in water with IC-MS/MS analysis
This PFAS toolkit will help you achieve optimal analysis for Perfluoroalkyl substances
It is crucial to ensure safety and compliance for the world’s food supply, which is processed in different environments and under different regulations. Differences in pesticide development and implementation, as well as transportation and handling, make it complicated but important to develop workflow solutions to address current testing requirements as well as emerging threats and regulations. The TSQ Altis Plus mass spectrometer provides next-level performance to address these challenges.
Determination of cationic polar pesticides in cereals using ion chromatography and tandem mass spectroscopy
Multi-class veterinary drugs analyses of QuEChERS extracts using an automated online µSPE cleanup coupled to LC-MS/MS
Increasing throughput of the LC-MS analysis of pesticide residues in food: Using dual channel chromatography-triple quadrupole mass spectrometry
Triple quadrupole technology for Halvec Lab’s novel routine gelatin analysis and targeted markers for identification of porcine trace elements
Food and environmental safety applications: Address challenges and achieve confident data
Rapid quantitation of veterinary drugs in meat extracts using a VeriSpray PaperSpray source coupled to a TSQ Altis triple quadrupole mass spectrometer
Additional Resources
Explore solutions for food analytical testing
Themo Fisher Scientific products and services can help your lab run seamlessly, while enabling you to expand your menu of food analyses with innovative instruments and connected data to transform your output.
Providing innovative solutions to help meet the demanding needs of clinical, forensic, and translational research, Thermo Fisher Scientific workflow solutions combine effective front-end solutions to the TSQ Altis Plus mass spectrometer to deliver confident data.
Analysis of testosterone from human serum using FAIMS technology
Excel in productivity with the TSQ Altis mass spectrometer: Bridging the gap in large-scale lipid analysis through targeted acquisition
Detection of controlled substances in blood samples using the VeriSpray ion source with TSQ Altis MS for clinical research and forensic toxicology
Reducing SARS-CoV-2 false positives with LC-MS for viral and host protein detection
Improving targeted peptide quantification: Combining a TSQ Altis MS with a FAIMS Pro interface for peptides in complex matrices
Quantitative analysis of antifungal drugs using PaperSpray tandem mass spectrometry for clinical research
A new IC-MS/MS approach for the analysis of bisphosphonates in horse plasma
Additional Resources
Enabling accurate, quick results
Clinical research requires flexible instrumentation that enables the analysis of many types of analytes while providing robust, sensitive and time-saving solutions. Using Thermo Scientific LC-MS solutions, you can perform assays that address such challenges as monitoring drugs for immunosuppressants, investigating potential biomarkers for disease targets, or measuring the output of endocrine glands.
The bio/pharmaceutical drug development pipeline presents different challenges to researchers at every stage, from discovery through bioanalytical quantitation. Thermo Scientific TSQ Plus mass spectrometers leverage innovative hardware and software advancements to deliver productive solutions to enable our partners to deliver next-generation drugs to market faster with greater confidence.
Sensitive, robust quantitative analysis of a mixture of drug candidates in plasma using a TSQ Altis triple quadrupole mass spectrometer
Ultra-sensitive quantification of antibody biotherapeutics and biomarkers with a novel trapping-microLC-FAIMS/SRM-MS strategy
H-SRM isolation: improved selection and sensitivity for quantitation of protein biotherapeutics in plasma
Ordering information
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Remote monitoring
Connect your laboratory to drive more insights from your data
Thermo Fisher Connect Platform is part of our full suite of digital capabilities for secure, cloud-based data storage, scientific analysis apps, and peer collaboration tools. In addition, our asset management tools allow you to remotely schedule time on your lab’s instruments and monitor your run via your mobile device.
Using Thermo Fisher Connect, it’s easy to connect, save, and synchronize your files to your secure, personal account, which includes 1 TB of free storage. Peer and document collaboration tools enable secure group collaboration.
Learn more about how cloud-based technologies are becoming more prevalent in laboratories
Learn more about Thermo Fisher Connect Platform
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