Invitrogen

CD4 Monoclonal Antibody (GK1.5), eBioscience™

Advanced Verification

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.

96 Published Figures

345 References

View all (606) CD4 antibodies

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CD4 Antibody (14-0041-82) in Flow

Staining of C57Bl/6 splenocytes with 0.06 µg of Rat IgG2b Isotype Control Purified (Product # 14-4031-82) (open histogram) or 0.06 µg of Anti-Mouse CD4 Purified (filled histogram) followed by Anti-Rat IgG FITC (Product # 11-4811-85). Total viable cells were used for analysis.

CD4 Antibody in Immunocytochemistry (ICC/IF)

CD4 Antibody in Immunocytochemistry, Flow Cytometry (ICC/IF, Flow)

CD4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CD4 Antibody in Immunohistochemistry (Frozen) (IHC (F))

CD4 Antibody in Immunohistochemistry (IHC)

CD4 Antibody in Immunohistochemistry, Flow Cytometry (IHC, Flow)

CD4 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

Product Image Gallery

CD4 Antibody — Staining of mouse splenocytes. As expected based on known relative expression patterns, CD4 clone GK1.5 stains about 25% of total lymphocytes and does not stain CD45R (B220)+ B cells. Details: Balb/c splenocytes were surface stained with CD45R (B220, clone RA3-6B2) and Rat IgG2b Isotype Control or CD4 (clone GK1.5). Cells in the lymphocyte gate were used for analysis. {RE}

Product Details

14-0041-82

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

View 30 publications 30 publications

Immunohistochemistry (Paraffin) (IHC (P))

View 1 publication 1 publication

Immunohistochemistry (PFA fixed) (IHC (PFA))

View 1 publication 1 publication

Immunohistochemistry (Frozen) (IHC (F))

Assay-Dependent

View 6 publications 6 publications

Immunocytochemistry (ICC/IF)

View 11 publications 11 publications

Flow Cytometry (Flow)

0.125 µg/test

View 277 publications 277 publications

Immunoprecipitation (IP)

Assay-Dependent

Neutralization (Neu)

View 1 publication 1 publication

Functional Assay (Functional)

View 16 publications 16 publications

Miscellaneous PubMed (Misc)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Mouse

Published species

Fish, Human, Mouse, Rat

Host/Isotype

Rat / IgG2b, kappa

Class

Monoclonal

Type

Antibody

Clone

GK1.5

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4° C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_467063

Product Specific Information

Description: The GK1.5 monoclonal antibody reacts with the mouse CD4 molecule, a 55 kDa cell surface receptor expressed by a majority of thymocytes, subpopulation of mature T cells and dendritic cells. CD4 binds to MHC class II on the surface of antigen presenting cells and plays an important role both in T cell development and in optimal functioning of mature T cells. In T cells, CD4 associates with protein tyrosine kinase p56lck through its cytoplasmic tail. Binding of GK1.5 is blocked by RM4-5.

Applications Reported: The GK1.5 antibody has been reported for use in flow cytometric analysis, immunoprecipitation, and immunohistochemical staining of frozen tissue sections. It has also been reported in isolation and depletion of CD4+ cells, blocking of ligand binding and T cell activation via CD4. (Please use Functional Grade purified GK1.5, Product # 16-0041, in functional assays).

Applications Tested: The GK1.5 antibody has been tested by flow cytometric analysis of mouse thymocytes and splenocytes. This can be used at less than or equal to 0.125 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Purity: Greater than 90%, as determined by SDS-PAGE.

Aggregation: Less than 10%, as determined by HPLC.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017].

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Fasudil-modified macrophages reduce inflammation and regulate the immune response in experimental autoimmune encephalomyelitis.

Neural regeneration research

Liu C,Guo S,Liu R,Guo M,Wang Q,Chai Z,Xiao B,Ma C

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Fri Mar 01 00:00:00 EST 2024

YAP/STAT3 inhibited CD8⁺ T cells activity in the breast cancer immune microenvironment by inducing M2 polarization of tumor-associated macrophages.

Cancer medicine

Wang C,Shen N,Guo Q,Tan X,He S

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Tue Aug 01 00:00:00 EDT 2023

B cell extracellular vesicles contain monomeric IgM that binds antigen and enters target cells.

iScience

Gutknecht MF,Holodick NE,Rothstein TL

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Fri Sep 15 00:00:00 EDT 2023

Subconjunctival injection of human umbilical cord mesenchymal stem cells alleviates experimental allergic conjunctivitis via regulating T cell response.

Stem cell research & therapy

Li D,Ou Q,Shen Q,Lu MM,Xu JY,Jin C,Gao F,Wang J,Zhang J,Zhang J,Li J,Lu L,Xu GT,Tian H

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Mon Oct 02 00:00:00 EDT 2023

Respiratory mucosal vaccination of peptide-poloxamine-DNA nanoparticles provides complete protection against lethal SARS-CoV-2 challenge.

Biomaterials

Sun S,Li E,Zhao G,Tang J,Zuo Q,Cai L,Xu C,Sui C,Ou Y,Liu C,Li H,Ding Y,Li C,Lu D,Zhang W,Luo P,Cheng P,Gao Y,Tu C,Pitard B,Rosenecker J,Wang B,Liu Y,Zou Q,Guan S

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Sun Jan 01 00:00:00 EST 2023

HSF1 promotes CD69⁺ Treg differentiation to inhibit colitis progression.

Theranostics

Yu L,Zhou B,Zhu Y,Li L,Zhong Y,Zhu L,Wang H,Chen H,Xu J,Guo T,Feng L,Wang X,Cai Z,Wang J,Jin H

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Tue Apr 18 00:00:00 EDT 2023

Prolidase Deficiency Causes Spontaneous T Cell Activation and Lupus-like Autoimmunity.

Journal of immunology (Baltimore, Md. : 1950)

Hodgson R,Crockford TL,Bhandari A,Kepple JD,Back J,Cawthorne E,Abeler-Dörner L,Laing AG,Clare S,Speak A,Adams DJ,Dougan G,Hayday AC,Deobagkar-Lele M,Cornall RJ,Bull KR

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2023

Development of a Syrian hamster anti-PD-L1 monoclonal antibody enables oncolytic adenoviral immunotherapy modelling in an immunocompetent virus replication permissive setting.

Frontiers in immunology

Clubb JHA,Kudling TV,Girych M,Haybout L,Pakola S,Hamdan F,Cervera-Carrascon V,Hemmes A,Grönberg-Vähä-Koskela S,Santos JM,Quixabeira DCA,Basnet S,Heiniö C,Arias V,Jirovec E,Kaptan S,Havunen R,Sorsa S,Erikat A,Schwartz J,Anttila M,Aro K,Viitala T,Vattulainen I,Cerullo V,Kanerva A,Hemminki A

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Mon Feb 27 00:00:00 EST 2023

GH18 family glycoside hydrolase Chitinase A of Salmonella enhances virulence by facilitating invasion and modulating host immune responses.

PLoS pathogens

Chandra K,Roy Chowdhury A,Chatterjee R,Chakravortty D

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Fri Apr 01 00:00:00 EDT 2022

Rotenone aggravates PD-like pathology in A53T mutant human α-synuclein transgenic mice in an age-dependent manner.

Frontiers in aging neuroscience

Chen AD,Cao JX,Chen HC,Du HL,Xi XX,Sun J,Yin J,Jing YH,Gao LP

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Fri Aug 26 00:00:00 EDT 2022

IL-33 Deficiency Attenuates Lung Inflammation by Inducing Th17 Response and Impacting the Th17/Treg Balance in LPS-Induced ARDS Mice via Dendritic Cells.

Journal of immunology research

Cheng L,Jiao Y,Jiang W,Zhang X,Zhang L,Jia G

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Tue Dec 27 00:00:00 EST 2022

Interferon-γ Stimulates Interleukin-27 Derived from Dendritic Cells to Regulate Th9 Differentiation through STAT1/3 Pathway.

Disease markers

Xiong P,Liu T,Chen Y,Xu Q,Hu X,Han F,Shi L

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Mon Oct 31 00:00:00 EDT 2022

CD4⁺ CTLs Act as a Key Effector Population for Allograft Rejection of MSCs in a Donor MHC-II Dependent Manner in Injured Liver.

Aging and disease

Shen S,Li Y,Jin M,Fan D,Pan R,Lin A,Chen Y,Xiang L,Zhao RC,Shao J

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Thu Dec 01 00:00:00 EST 2022

Free Fatty Acid Receptor 4 (FFA4) Activation Ameliorates Imiquimod-Induced Psoriasis in Mice.

International journal of molecular sciences

Son SE,Koh JM,Im DS

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Tue Apr 19 00:00:00 EDT 2022

Btla signaling in conventional and regulatory lymphocytes coordinately tempers humoral immunity in the intestinal mucosa.

Cell reports

Stienne C,Virgen-Slane R,Elmén L,Veny M,Huang S,Nguyen J,Chappell E,Balmert MO,Shui JW,Hurchla MA,Kronenberg M,Peterson SN,Murphy KM,Ware CF,Šedý JR

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Immunohistochemistry

Tue Mar 22 00:00:00 EDT 2022

Valosin-containing protein (VCP/p97) inhibition reduces viral clearance and induces toxicity associated with muscular damage.

Cell death & disease

Del Rio Oliva M,Basler M

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Thu Dec 01 00:00:00 EST 2022

Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis.

Immunity

Almeida L,Dhillon-LaBrooy A,Castro CN,Adossa N,Carriche GM,Guderian M,Lippens S,Dennerlein S,Hesse C,Lambrecht BN,Berod L,Schauser L,Blazar BR,Kalesse M,Müller R,Moita LF,Sparwasser T

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Tue Jan 12 00:00:00 EST 2021

Cell-mimicking nanodecoys neutralize SARS-CoV-2 and mitigate lung injury in a non-human primate model of COVID-19.

Nature nanotechnology

Li Z,Wang Z,Dinh PC,Zhu D,Popowski KD,Lutz H,Hu S,Lewis MG,Cook A,Andersen H,Greenhouse J,Pessaint L,Lobo LJ,Cheng K

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Immunocytochemistry

Sun Aug 01 00:00:00 EDT 2021

NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity.

Nature immunology

Gu M,Zhou X,Sohn JH,Zhu L,Jie Z,Yang JY,Zheng X,Xie X,Yang J,Shi Y,Brightbill HD,Kim JB,Wang J,Cheng X,Sun SC

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2021

Porphyromonas gingivalis exacerbates ulcerative colitis via Porphyromonas gingivalis peptidylarginine deiminase.

International journal of oral science

Zhao X,Liu J,Zhang C,Yu N,Lu Z,Zhang S,Li Y,Li Q,Liu J,Liu D,Pan Y

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Thu Sep 30 00:00:00 EDT 2021

Uncovering a novel role of PLCβ4 in selectively mediating TCR signaling in CD8+ but not CD4+ T cells.

The Journal of experimental medicine

Sasai M,Ma JS,Okamoto M,Nishino K,Nagaoka H,Takashima E,Pradipta A,Lee Y,Kosako H,Suh PG,Yamamoto M

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Mon Jul 05 00:00:00 EDT 2021

Splicing factor SRSF1 limits IFN-γ production via RhoH and ameliorates experimental nephritis.

Rheumatology (Oxford, England)

Katsuyama T,Li H,Krishfield SM,Kyttaris VC,Moulton VR

14-0041-82 was used in Flow Cytometry to uncover a previously unrecognized role of SRSF1 in restraining IFN-γ production and Th1 differentiation through the control of RhoH.

Tue Jan 05 00:00:00 EST 2021

High Ambient Temperature Aggravates Experimental Autoimmune Uveitis Symptoms.

Frontiers in cell and developmental biology

Pan S,Tan H,Chang R,Wang Q,Zhu Y,Chen L,Li H,Su G,Zhou C,Cao Q,Kijlstra A,Yang P

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Tue Apr 13 00:00:00 EDT 2021

Dynamic changes in the systemic immune responses of spinal cord injury model mice.

Neural regeneration research

Gao TY,Huang FF,Xie YY,Wang WQ,Wang LD,Mu D,Cui Y,Wang B

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2021

SZB120 Exhibits Immunomodulatory Effects by Targeting eIF2α to Suppress Th17 Cell Differentiation.

Journal of immunology (Baltimore, Md. : 1950)

Chen L,Bai J,Peng D,Gao Y,Cai X,Zhang J,Tang S,Niu L,Sun Y,Lou F,Zhou H,Yin Q,Wang Z,Sun L,Du X,Xu Z,Wang H,Li Q,Wang H

14-0041-82 was used in Flow Cytometry to characterise the target and mechanism of an acetylated beta-boswellic acid derivative termed SZB120, and evaluate the anti-inflammatory activities in vitro and in vivo.

Mon Mar 01 00:00:00 EST 2021

Generation of a Novel Oncolytic Vaccinia Virus Using the IHD-W Strain.

Human gene therapy

Shin J,Hong SO,Kim M,Lee H,Choi H,Kim J,Hong J,Kang H,Lee E,Lee S,Kong B,Kim M,Choi H,Kim S

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Sat May 01 00:00:00 EDT 2021

Oncolytic Herpes Simplex Virus Type 2 Can Effectively Inhibit Colorectal Cancer Liver Metastasis by Modulating the Immune Status in the Tumor Microenvironment and Inducing Specific Antitumor Immunity.

Human gene therapy

Zhang W,Zeng B,Hu X,Zou L,Liang J,Song Y,Liu B,Liu S

14-0041 was used in Immunohistochemistry to show that oHSV2 can effectively kill the primary tumour and attack distal and metastatic tumours by inducing immune responses, resulting in lasting antitumour efficacy and preventing tumour recurrence.

Mon Feb 01 00:00:00 EST 2021

CXCR3 alleviates renal ischemia‑reperfusion injury via increase of Tregs.

Molecular medicine reports

Xian W,Wu J,Li Q,Du X,Wang N,Chen D,Gao W,Cao J

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Thu Jul 01 00:00:00 EDT 2021

Irradiated whole-cell vaccine suppresses hepatocellular carcinoma growth in mice via Th9 cells.

Oncology letters

Chen J,Ding Y,Huang F,Lan R,Wang Z,Huang W,Chen R,Wu B,Fu L,Yang Y,Liu J,Hong J,Zhang W,Zhang L

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Sat May 01 00:00:00 EDT 2021

Preliminary analysis of immunoregulatory mechanism of hyperhomocysteinemia-induced brain injury in Wistar-Kyoto rats.

Experimental and therapeutic medicine

Zhang Y,Wang L,Li X,Geng J

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Sat May 01 00:00:00 EDT 2021

Estrogen receptor beta signaling in CD8⁺ T cells boosts T cell receptor activation and antitumor immunity through a phosphotyrosine switch.

Journal for immunotherapy of cancer

Yuan B,Clark CA,Wu B,Yang J,Drerup JM,Li T,Jin VX,Hu Y,Curiel TJ,Li R

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Fri Jan 01 00:00:00 EST 2021

TNFRSF13B genotypes control immune-mediated pathology by regulating the functions of innate B cells.

JCI insight

de Mattos Barbosa MG,Lefferts AR,Huynh D,Liu H,Zhang Y,Fu B,Barnes J,Samaniego M,Bram RJ,Geha RS,Shikanov A,Prak ETL,Farkash EA,Platt JL,Cascalho M

14-0041-82 was used in Immunohistochemistry (Frozen) to conclude that the wide variation in inflammatory reactions associated with TNFRSF13B diversity suggests polymorphisms could underlie variation in host defense and explosive inflammatory responses that sometimes enhance morbidity associated with immune responses.

Wed Sep 08 00:00:00 EDT 2021

TNFRSF13B genotypes control immune-mediated pathology by regulating the functions of innate B cells.

JCI insight

de Mattos Barbosa MG,Lefferts AR,Huynh D,Liu H,Zhang Y,Fu B,Barnes J,Samaniego M,Bram RJ,Geha RS,Shikanov A,Prak ETL,Farkash EA,Platt JL,Cascalho M

Wed Sep 08 00:00:00 EDT 2021

Neuroimmune Consequences of eIF4E Phosphorylation on Chemotherapy-Induced Peripheral Neuropathy.

Frontiers in immunology

Agalave NM,Mody PH,Szabo-Pardi TA,Jeong HS,Burton MD

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Mon Sep 20 00:00:00 EDT 2021

Alphavirus-Driven Interferon Gamma (IFNg) Expression Inhibits Tumor Growth in Orthotopic 4T1 Breast Cancer Model.

Vaccines

Trofimova O,Korotkaja K,Skrastina D,Jansons J,Spunde K,Isaguliants M,Zajakina A

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Wed Oct 27 00:00:00 EDT 2021

A lymph node-targeted Amphiphile vaccine induces potent cellular and humoral immunity to SARS-CoV-2.

Science advances

Steinbuck MP,Seenappa LM,Jakubowski A,McNeil LK,Haqq CM,DeMuth PC

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2021

Positive Effects of Oral Antibiotic Administration in Murine Chronic Graft-Versus-Host Disease.

International journal of molecular sciences

Sato S,Shimizu E,He J,Ogawa M,Asai K,Yazu H,Rusch R,Yamane M,Yang F,Fukuda S,Kawakami Y,Tsubota K,Ogawa Y

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Immunohistochemistry

Sat Apr 03 00:00:00 EDT 2021

Positive Effects of Oral Antibiotic Administration in Murine Chronic Graft-Versus-Host Disease.

International journal of molecular sciences

Sato S,Shimizu E,He J,Ogawa M,Asai K,Yazu H,Rusch R,Yamane M,Yang F,Fukuda S,Kawakami Y,Tsubota K,Ogawa Y

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Immunohistochemistry

Sat Apr 03 00:00:00 EDT 2021

Functional inhibition of lactate dehydrogenase suppresses pancreatic adenocarcinoma progression.

Clinical and translational medicine

Cheng CS,Tan HY,Wang N,Chen L,Meng Z,Chen Z,Feng Y

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Immunohistochemistry

Tue Jun 01 00:00:00 EDT 2021

IDO1 Expression in Ovarian Cancer Induces PD-1 in T Cells via Aryl Hydrocarbon Receptor Activation.

Frontiers in immunology

Amobi-McCloud A,Muthuswamy R,Battaglia S,Yu H,Liu T,Wang J,Putluri V,Singh PK,Qian F,Huang RY,Putluri N,Tsuji T,Lugade AA,Liu S,Odunsi K

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Fri Oct 29 00:00:00 EDT 2021

Mesenchymal stem cell exosome-derived miR-223 alleviates acute graft-versus-host disease via reducing the migration of donor T cells.

Stem cell research & therapy

Liu W,Zhou N,Liu Y,Zhang W,Li X,Wang Y,Zheng R,Zhang Y

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Fri Feb 26 00:00:00 EST 2021

G-MDSCs promote aging-related cardiac fibrosis by activating myofibroblasts and preventing senescence.

Cell death & disease

Sun SN,Ni SH,Li Y,Liu X,Deng JP,Chen ZX,Li H,Feng WJ,Huang YS,Li DN,Xian SX,Yang ZQ,Wang LJ,Lu L

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Tue Jun 08 00:00:00 EDT 2021

Butyrate Improves Skin/Lung Fibrosis and Intestinal Dysbiosis in Bleomycin-Induced Mouse Models.

International journal of molecular sciences

Park HJ,Jeong OY,Chun SH,Cheon YH,Kim M,Kim S,Lee SI

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Tue Mar 09 00:00:00 EST 2021

Mapping Rora expression in resting and activated CD4+ T cells.

PloS one

Haim-Vilmovsky L,Henriksson J,Walker JA,Miao Z,Natan E,Kar G,Clare S,Barlow JL,Charidemou E,Mamanova L,Chen X,Proserpio V,Pramanik J,Woodhouse S,Protasio AV,Efremova M,Griffin JL,Berriman M,Dougan G,Fisher J,Marioni JC,McKenzie ANJ,Teichmann SA

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Fri Nov 12 00:00:00 EST 2021

Type 2 diabetic mice enter a state of spontaneous hibernation-like suspended animation following accumulation of uric acid.

The Journal of biological chemistry

Zhao Y,Cheng R,Zhao Y,Ge W,Yang Y,Ding Z,Xu X,Wang Z,Wu Z,Zhang J

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Fri Oct 01 00:00:00 EDT 2021

Targeting Ovarian Carcinoma with TSP-1:CD47 Antagonist TAX2 Activates Anti-Tumor Immunity.

Cancers

Jeanne A,Sarazin T,Charlé M,Moali C,Fichel C,Boulagnon-Rombi C,Callewaert M,Andry MC,Diesis E,Delolme F,Rioult D,Dedieu S

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Thu Oct 07 00:00:00 EDT 2021

Targeting Ovarian Carcinoma with TSP-1:CD47 Antagonist TAX2 Activates Anti-Tumor Immunity.

Cancers

Jeanne A,Sarazin T,Charlé M,Moali C,Fichel C,Boulagnon-Rombi C,Callewaert M,Andry MC,Diesis E,Delolme F,Rioult D,Dedieu S

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Thu Oct 07 00:00:00 EDT 2021

A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis.

Nature communications

Wang G,Xie L,Li B,Sang W,Yan J,Li J,Tian H,Li W,Zhang Z,Tian Y,Dai Y

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Thu Sep 30 00:00:00 EDT 2021

Oxygen-Enriched Metal-Phenolic X-Ray Nanoprocessor for Cancer Radio-Radiodynamic Therapy in Combination with Checkpoint Blockade Immunotherapy.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Sang W,Xie L,Wang G,Li J,Zhang Z,Li B,Guo S,Deng CX,Dai Y

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2021

Systemic Delivery of Oncolytic Adenovirus to Tumors Using Tumor-Infiltrating Lymphocytes as Carriers.

Cells

Santos J,Heiniö C,Quixabeira D,Zafar S,Clubb J,Pakola S,Cervera-Carrascon V,Havunen R,Kanerva A,Hemminki A

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Thu Apr 22 00:00:00 EDT 2021

Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response.

Cell reports

Vaena S,Chakraborty P,Lee HG,Janneh AH,Kassir MF,Beeson G,Hedley Z,Yalcinkaya A,Sofi MH,Li H,Husby ML,Stahelin RV,Yu XZ,Mehrotra S,Ogretmen B

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Immunocytochemistry

Tue May 04 00:00:00 EDT 2021

Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the gut microbiota.

Theranostics

Tong L,Hao H,Zhang Z,Lv Y,Liang X,Liu Q,Liu T,Gong P,Zhang L,Cao F,Pastorin G,Lee CN,Chen X,Wang JW,Yi H

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Fri Jan 28 00:00:00 EST 2022

Inducible T-Cell Costimulator Mediates Lymphocyte/Macrophage Interactions During Liver Repair.

Frontiers in immunology

Ramavath NN,Gadipudi LL,Provera A,Gigliotti LC,Boggio E,Bozzola C,Albano E,Dianzani U,Sutti S

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Mon Feb 14 00:00:00 EST 2022

Remote Limb Ischemic Postconditioning Protects Against Ischemic Stroke by Promoting Regulatory T Cells Thriving.

Journal of the American Heart Association

Yu HH,Ma XT,Ma X,Chen M,Chu YH,Wu LJ,Wang W,Qin C,Tian DS

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Tue Nov 16 00:00:00 EST 2021

Epinephrine Production in Th17 Cells and Experimental Autoimmune Encephalitis.

Frontiers in immunology

Yang P,Tian H,Zou YR,Chambon P,Ichinose H,Honig G,Diamond B,Kim SJ

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Mon Jul 05 00:00:00 EDT 2021

Epinephrine Production in Th17 Cells and Experimental Autoimmune Encephalitis.

Frontiers in immunology

Yang P,Tian H,Zou YR,Chambon P,Ichinose H,Honig G,Diamond B,Kim SJ

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Mon Jul 05 00:00:00 EDT 2021

Antagonistic Inflammatory Phenotypes Dictate Tumor Fate and Response to Immune Checkpoint Blockade.

Immunity

Bonavita E,Bromley CP,Jonsson G,Pelly VS,Sahoo S,Walwyn-Brown K,Mensurado S,Moeini A,Flanagan E,Bell CR,Chiang SC,Chikkanna-Gowda CP,Rogers N,Silva-Santos B,Jaillon S,Mantovani A,Reis e Sousa C,Guerra N,Davis DM,Zelenay S

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Tue Dec 15 00:00:00 EST 2020

Splenic Capture and In Vivo Intracellular Biodegradation of Biological-Grade Graphene Oxide Sheets.

ACS nano

Newman L,Jasim DA,Prestat E,Lozano N,de Lazaro I,Nam Y,Assas BM,Pennock J,Haigh SJ,Bussy C,Kostarelos K

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Tue Aug 25 00:00:00 EDT 2020

Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.

The Journal of experimental medicine

Kang YA,Pietras EM,Passegué E

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Mon Mar 02 00:00:00 EST 2020

Runx proteins mediate protective immunity against Leishmania donovani infection by promoting CD40 expression on dendritic cells.

PLoS pathogens

Akhtar MN,Mishra M,Yadav V,Yadav M,Gujar R,Lal S,Kumar R,Khatri N,Sen P

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Tue Dec 01 00:00:00 EST 2020

DEK-targeting aptamer DTA-64 attenuates bronchial EMT-mediated airway remodelling by suppressing TGF-β1/Smad, MAPK and PI3K signalling pathway in asthma.

Journal of cellular and molecular medicine

Song Y,Wang Z,Jiang J,Piao Y,Li L,Xu C,Piao H,Li L,Yan G

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Tue Dec 01 00:00:00 EST 2020

Enhanced alleviation of aGVHD by TGF-β1-modified mesenchymal stem cells in mice through shifting MΦ into M2 phenotype and promoting the differentiation of Treg cells.

Journal of cellular and molecular medicine

Wu R,Liu C,Deng X,Chen L,Hao S,Ma L

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Wed Jan 01 00:00:00 EST 2020

HDAC Inhibitor, CG-745, Enhances the Anti-Cancer Effect of Anti-PD-1 Immune Checkpoint Inhibitor by Modulation of the Immune Microenvironment.

Journal of Cancer

Kim YD,Park SM,Ha HC,Lee AR,Won H,Cha H,Cho S,Cho JM

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Mon Sep 28 00:00:00 EDT 2020

Loss of Setd4 delays radiation-induced thymic lymphoma in mice.

DNA repair

Feng X,Lu H,Yue J,Schneider N,Liu J,Denzin LK,Chan CS,De S,Shen Z

14-0041 was used in Immunohistochemistry to report that conditional Setd4 deletion in adult mice significantly extended the survival of radiation-induced T-lymphoma.

Sat Feb 01 00:00:00 EST 2020

Effects of combined treatment with PD‑L1 Ig and CD40L mAb on immune tolerance in the CBA/J x DBA/2 mouse model.

Molecular medicine reports

Li G,Yang L,Li D,Zhang J,Du L,Xia L,Liu Y,Hu W

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Wed Apr 01 00:00:00 EDT 2020

Elevated granulocytic myeloid-derived suppressor cells are closely related with elevation of Th17 cells in mice with experimental asthma.

International journal of biological sciences

Xue F,Yu M,Li L,Zhang W,Ma Y,Dong L,Shan W,Zheng Y,Wang T,Feng D,Lv J,Wang X

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Fri Nov 12 00:00:00 EST 2021

Comparative Analysis of Age-Related Changes in Lacrimal Glands and Meibomian Glands of a C57BL/6 Male Mouse Model.

International journal of molecular sciences

Yoon CH,Ryu JS,Hwang HS,Kim MK

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Thu Jun 11 00:00:00 EDT 2020

Truncated PPM1D Prevents Apoptosis in the Murine Thymus and Promotes Ionizing Radiation-Induced Lymphoma.

Cells

Martinikova AS,Burocziova M,Stoyanov M,Macurek L

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Thu Sep 10 00:00:00 EDT 2020

Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target.

JCI insight

Pierini S,Tanyi JL,Simpkins F,George E,Uribe-Herranz M,Drapkin R,Burger R,Morgan MA,Facciabene A

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Thu Aug 20 00:00:00 EDT 2020

A micropeptide encoded by lncRNA MIR155HG suppresses autoimmune inflammation via modulating antigen presentation.

Science advances

Niu L,Lou F,Sun Y,Sun L,Cai X,Liu Z,Zhou H,Wang H,Wang Z,Bai J,Yin Q,Zhang J,Chen L,Peng D,Xu Z,Gao Y,Tang S,Fan L,Wang H

14-0041-82 was used in Flow Cytometry to demonstrate the endogenous existence of a micropeptide encoded by a transcript annotated as "non-protein coding" and characterize a micropeptide as a regulator of antigen presentation and a suppressor of inflammatory diseases.

Fri May 01 00:00:00 EDT 2020

FUT1 deficiency elicits immune dysregulation and corneal opacity in steady state and under stress.

Cell death & disease

Kim KW,Ryu JS,Ko JH,Kim JY,Kim HJ,Lee HJ,Oh JH,Chung JH,Oh JY

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Fri Apr 24 00:00:00 EDT 2020

The Proteomic Landscape of Resting and Activated CD4+ T Cells Reveal Insights into Cell Differentiation and Function.

International journal of molecular sciences

Subbannayya Y,Haug M,Pinto SM,Mohanty V,Meås HZ,Flo TH,Prasad TSK,Kandasamy RK

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Tue Dec 29 00:00:00 EST 2020

Antimesothelioma Immunotherapy by CTLA-4 Blockade Depends on Active PD1-Based TWIST1 Vaccination.

Molecular therapy oncolytics

Tan Z,Chiu MS,Yan CW,Wong YC,Huang H,Man K,Chen Z

14-0041-82 was used in Flow Cytometry to demonstrate that TWIST1, the basic helix-loop-helix transcription factor, was associated with human mesothelioma tumorigenesis and is required for the invasion and metastasis of mesothelioma in the immune-competent murine AB1 model.

Fri Mar 27 00:00:00 EDT 2020

Artificial Mini Dendritic Cells Boost T Cell-Based Immunotherapy for Ovarian Cancer.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Cheng S,Xu C,Jin Y,Li Y,Zhong C,Ma J,Yang J,Zhang N,Li Y,Wang C,Yang Z,Wang Y

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Wed Apr 01 00:00:00 EDT 2020

ICOS agonism by JTX-2011 (vopratelimab) requires initial T cell priming and Fc cross-linking for optimal T cell activation and anti-tumor immunity in preclinical models.

PloS one

Hanson A,Elpek K,Duong E,Shallberg L,Fan M,Johnson C,Wallace M,Mabry GR,Sazinsky S,Pepper L,Shu CJ,Sathyanarayanan S,Zuerndorfer S,Simpson T,Gostissa M,Briskin M,Law D,Michaelson J,Harvey CJ

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Mon Nov 16 00:00:00 EST 2020

Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models.

Communications biology

Waaler J,Mygland L,Tveita A,Strand MF,Solberg NT,Olsen PA,Aizenshtadt A,Fauskanger M,Lund K,Brinch SA,Lycke M,Dybing E,Nygaard V,Bøe SL,Heintz KM,Hovig E,Hammarström C,Corthay A,Krauss S

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Fri Apr 24 00:00:00 EDT 2020

Tregitopes regulate the tolerogenic immune response and decrease the foetal death rate in abortion-prone mouse matings.

Scientific reports

Kedzierska AE,Lorek D,Slawek A,Chelmonska-Soyta A

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Mon Jun 29 00:00:00 EDT 2020

Distinct Waves from the Hemogenic Endothelium Give Rise to Layered Lymphoid Tissue Inducer Cell Ontogeny.

Cell reports

Simic M,Manosalva I,Spinelli L,Gentek R,Shayan RR,Siret C,Girard-Madoux M,Wang S,de Fabritus L,Verschoor J,Kerdiles YM,Bajenoff M,Stumm R,Golub R,van de Pavert SA

14-0041-81 was used in Immunocytochemistry to identify a major contribution from embryonic hemogenic endothelium, but not the yolk sac, toward LTi progenitors.

Tue Aug 11 00:00:00 EDT 2020

Bixin Attenuates Experimental Autoimmune Encephalomyelitis by Suppressing TXNIP/NLRP3 Inflammasome Activity and Activating NRF2 Signaling.

Frontiers in immunology

Yu Y,Wu DM,Li J,Deng SH,Liu T,Zhang T,He M,Zhao YY,Xu Y

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Mon Jun 21 00:00:00 EDT 2021

Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation.

Nature

Wilkinson AC,Ishida R,Kikuchi M,Sudo K,Morita M,Crisostomo RV,Yamamoto R,Loh KM,Nakamura Y,Watanabe M,Nakauchi H,Yamazaki S

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Mon Jul 01 00:00:00 EDT 2019

TBKBP1 and TBK1 form a growth factor signalling axis mediating immunosuppression and tumourigenesis.

Nature cell biology

Zhu L,Li Y,Xie X,Zhou X,Gu M,Jie Z,Ko CJ,Gao T,Hernandez BE,Cheng X,Sun SC

14-0041 was used in Flow cytometry/Cell sorting to suggest a PKCθ-TBKBP1-TBK1 growth factor signalling axis that mediates both tumour growth and immunosuppression.

Sun Dec 01 00:00:00 EST 2019

Mechanisms of action of ruxolitinib in murine models of hemophagocytic lymphohistiocytosis.

Blood

Albeituni S,Verbist KC,Tedrick PE,Tillman H,Picarsic J,Bassett R,Nichols KE

14-0041-82 was used in Flow Cytometry to show that ruxolitinib operates through IFN-γ-dependent and -independent mechanisms to dampen HLH by targeting the deleterious effects of T cells and neutrophils, with the latter representing an unappreciated and understudied cell type that contributes to HLH pathogenesis.

Thu Jul 11 00:00:00 EDT 2019

Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth.

EMBO molecular medicine

Thilakasiri P,Huynh J,Poh AR,Tan CW,Nero TL,Tran K,Parslow AC,Afshar-Sterle S,Baloyan D,Hannan NJ,Buchert M,Scott AM,Griffin MD,Hollande F,Parker MW,Putoczki TL,Ernst M,Chand AL

14-0041-82 was used in Flow Cytometry to establish the in vivo utility of bazedoxifene, a steroid analog clinically approved for the treatment of osteoporosis, to suppress gp130-dependent tumor growth of the gastrointestinal epithelium.

Mon Apr 01 00:00:00 EDT 2019

GARP Dampens Cancer Immunity by Sustaining Function and Accumulation of Regulatory T Cells in the Colon.

Cancer research

Salem M,Wallace C,Velegraki M,Li A,Ansa-Addo E,Metelli A,Kwon H,Riesenberg B,Wu B,Zhang Y,Guglietta S,Sun S,Liu B,Li Z

14-0041-82 was used in Flow Cytometry to demonstrate that loss of GARP in Treg cells leads to spontaneous inflammation with highly activated CD4+ and CD8+ T cells and development of enteritis.

Fri Mar 15 00:00:00 EDT 2019

Fimasartan reduces neointimal formation and inflammation after carotid arterial injury in apolipoprotein E knockout mice.

Molecular medicine (Cambridge, Mass.)

Kim JH,Lim IR,Joo HJ,Park CY,Choi SC,Jeong HS,Hong SJ

14-0041 was used in Immunohistochemistry to study the effects of fimasartan on neointimal formation and systemic inflammation following carotid artery injury.

Mon Jul 15 00:00:00 EDT 2019

Fimasartan reduces neointimal formation and inflammation after carotid arterial injury in apolipoprotein E knockout mice.

Molecular medicine (Cambridge, Mass.)

Kim JH,Lim IR,Joo HJ,Park CY,Choi SC,Jeong HS,Hong SJ

14-0041 was used in Immunohistochemistry to study the effects of fimasartan on neointimal formation and systemic inflammation following carotid artery injury.

Mon Jul 15 00:00:00 EDT 2019

Characterization of immune cell subtypes in three commonly used mouse strains reveals gender and strain-specific variations.

Laboratory investigation; a journal of technical methods and pathology

Hensel JA,Khattar V,Ashton R,Ponnazhagan S

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Tue Jan 01 00:00:00 EST 2019

Bryostatin-1 ameliorated experimental colitis in Il-10^-/- Mice by protecting the intestinal barrier and limiting immune dysfunction.

Journal of cellular and molecular medicine

Zuo L,Li J,Ge S,Ge Y,Shen M,Wang Y,Zhou C,Wu R,Hu J

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Thu Aug 01 00:00:00 EDT 2019

Lactobacillus rhamnosus GG attenuates tenofovir disoproxil fumarate-induced bone loss in male mice via gut-microbiota-dependent anti-inflammation.

Therapeutic advances in chronic disease

Liu H,Gu R,Li W,Zhou W,Cong Z,Xue J,Liu Y,Wei Q,Zhou Y

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Sat Apr 09 00:00:00 EDT 2022

Interleukin 10 Gene-Modified Bone Marrow-Derived Dendritic Cells Attenuate Liver Fibrosis in Mice by Inducing Regulatory T Cells and Inhibiting the TGF-β/Smad Signaling Pathway.

Mediators of inflammation

Xu Y,Tang X,Yang M,Zhang S,Li S,Chen Y,Liu M,Guo Y,Lu M

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Tue Jun 11 00:00:00 EDT 2019

Diabetes-mediated IL-17A enhances retinal inflammation, oxidative stress, and vascular permeability.

Cellular immunology

Sigurdardottir S,Zapadka TE,Lindstrom SI,Liu H,Taylor BE,Lee CA,Kern TS,Taylor PR

14-0041-82 was used in Flow Cytometry to examine the role of IL-17A in the development of retinal inflammation and long-term vascular pathology in diabetic mice.

Mon Jul 01 00:00:00 EDT 2019

IL-31 plays dual roles in lung inflammation in an OVA-induced murine asthma model.

Biology open

Huang J,Yue H,Jiang T,Gao J,Shi Y,Shi B,Wu X,Gou X

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Tue Jan 15 00:00:00 EST 2019

Antitumor and immunomodulatory effects of a novel multitarget inhibitor, CS2164, in mouse hepatocellular carcinoma models.

Anti-cancer drugs

Zhou Y,Fu C,Kong Y,Pan D,Wang Y,Huang S,Li Z,Ning Z,Lu X,Shan S,Xin L

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Tue Oct 01 00:00:00 EDT 2019

Epithelial EP4 plays an essential role in maintaining homeostasis in colon.

Scientific reports

Matsumoto Y,Nakanishi Y,Yoshioka T,Yamaga Y,Masuda T,Fukunaga Y,Sono M,Yoshikawa T,Nagao M,Araki O,Ogawa S,Goto N,Hiramatsu Y,Breyer RM,Fukuda A,Seno H

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Immunohistochemistry

Wed Oct 23 00:00:00 EDT 2019

Hemozoin produced by mammals confers heme tolerance.

eLife

Pek RH,Yuan X,Rietzschel N,Zhang J,Jackson L,Nishibori E,Ribeiro A,Simmons W,Jagadeesh J,Sugimoto H,Alam MZ,Garrett L,Haldar M,Ralle M,Phillips JD,Bodine DM,Hamza I

14-0041-82 was used in Flow Cytometry to show that mice deficient for the heme transporter SLC48A1 (also known as HRG1) accumulate over ten-fold excess heme in reticuloendothelial macrophage lysosomes that are 10 to 100 times larger than normal.

Tue Oct 01 00:00:00 EDT 2019

Specific Inhibition of Soluble γc Receptor Attenuates Collagen-Induced Arthritis by Modulating the Inflammatory T Cell Responses.

Frontiers in immunology

Lee B,Jo Y,Kim G,Ali LA,Sohn DH,Lee SG,Kim K,Shin E,Ryu SH,Hong C

14-0041 was used in Flow cytometry/Cell sorting to block the functions of sγc by inhibiting the formation of homodimeric sγc.

Tue Feb 25 00:00:00 EST 2020

An attenuated Zika virus NS4B protein mutant is a potent inducer of antiviral immune responses.

NPJ vaccines

Li G,Adam A,Luo H,Shan C,Cao Z,Fontes-Garfias CR,Sarathy VV,Teleki C,Winkelmann ER,Liang Y,Sun J,Bourne N,Barrett ADT,Shi PY,Wang T

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Thu Oct 01 00:00:00 EDT 2020

Next Generation Sequencing for Long Non-coding RNAs Profile for CD4⁺ T Cells in the Mouse Model of Acute Asthma.

Frontiers in genetics

Wang Z,Ji N,Chen Z,Wu C,Sun Z,Yu W,Hu F,Huang M,Zhang M

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Fri Apr 08 00:00:00 EDT 2022

Sex Differences in Mouse Popliteal Lymph Nodes.

Scientific reports

Dill-Garlow R,Chen KE,Walker AM

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Wed Jan 30 00:00:00 EST 2019

TLR1/2 Specific Small-Molecule Agonist Suppresses Leukemia Cancer Cell Growth by Stimulating Cytotoxic T Lymphocytes.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Cen X,Zhu G,Yang J,Yang J,Guo J,Jin J,Nandakumar KS,Yang W,Yin H,Liu S,Cheng K

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Fri May 17 00:00:00 EDT 2019

Pyruvate kinase M2 is requisite for Th1 and Th17 differentiation.

JCI insight

Kono M,Maeda K,Stocton-Gavanescu I,Pan W,Umeda M,Katsuyama E,Burbano C,Orite SYK,Vukelic M,Tsokos MG,Yoshida N,Tsokos GC

14-0041 was used in Flow cytometry/Cell sorting to demonstrate that CaMK4 binds to PKM2 and promotes its activity, which is requisite for Th1 and Th17 differentiation.

Thu Jun 20 00:00:00 EDT 2019

Inducible IL-7 Hyperexpression Influences Lymphocyte Homeostasis and Function and Increases Allograft Rejection.

Frontiers in immunology

Schreiber M,Weigelt M,Karasinsky A,Anastassiadis K,Schallenberg S,Petzold C,Bonifacio E,Kretschmer K,Hommel A

14-0041 was used in Flow cytometry/Cell sorting to show that transient hyperexpression of IL-7 can impair immune regulation, through disturbances in lymphocyte development pathways, and decrease graft survival time, even under immunosuppression.

Mon Sep 14 00:00:00 EDT 2020

Critical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells.

Oncoimmunology

Salerno F,Guislain A,Freen-Van Heeren JJ,Nicolet BP,Young HA,Wolkers MC

14-0041 was used in Flow cytometry/Cell sorting to conclude that post-transcriptional mechanisms could be modulated to potentiate effective T cell therapies in cancer.

Tue Jan 12 00:00:00 EST 2021

Molecular Profiling and Functional Analysis of Macrophage-Derived Tumor Extracellular Vesicles.

Cell reports

Cianciaruso C,Beltraminelli T,Duval F,Nassiri S,Hamelin R,Mozes A,Gallart-Ayala H,Ceada Torres G,Torchia B,Ries CH,Ivanisevic J,De Palma M

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Tue Jun 04 00:00:00 EDT 2019

CXCR5-negative natural killer cells ameliorate experimental autoimmune myasthenia gravis by suppressing follicular helper T cells.

Journal of neuroinflammation

Yang CL,Zhang P,Liu RT,Zhang N,Zhang M,Li H,Du T,Li XL,Dou YC,Duan RS

14-0041-82 was used in Flow Cytometry to investigate the function of NK cells in experimental autoimmune myasthenia gravis in vivo.

Sun Dec 29 00:00:00 EST 2019

Virus-Induced Interferon-γ Causes Insulin Resistance in Skeletal Muscle and Derails Glycemic Control in Obesity.

Immunity

Šestan M,Marinović S,Kavazović I,Cekinović Đ,Wueest S,Turk Wensveen T,Brizić I,Jonjić S,Konrad D,Wensveen FM,Polić B

14-0041 was used in Flow cytometry/Cell sorting to study how viral infection effects insulin resistance.

Tue Jul 17 00:00:00 EDT 2018

Tissue-Restricted Adaptive Type 2 Immunity Is Orchestrated by Expression of the Costimulatory Molecule OX40L on Group 2 Innate Lymphoid Cells.

Immunity

Halim TYF,Rana BMJ,Walker JA,Kerscher B,Knolle MD,Jolin HE,Serrao EM,Haim-Vilmovsky L,Teichmann SA,Rodewald HR,Botto M,Vyse TJ,Fallon PG,Li Z,Withers DR,McKenzie ANJ

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Tue Jun 19 00:00:00 EDT 2018

Nox2 in regulatory T cells promotes angiotensin II-induced cardiovascular remodeling.

The Journal of clinical investigation

Emmerson A,Trevelin SC,Mongue-Din H,Becker PD,Ortiz C,Smyth LA,Peng Q,Elgueta R,Sawyer G,Ivetic A,Lechler RI,Lombardi G,Shah AM

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Mon Jul 02 00:00:00 EDT 2018

Autophagy orchestrates the regulatory program of tumor-associated myeloid-derived suppressor cells.

The Journal of clinical investigation

Alissafi T,Hatzioannou A,Mintzas K,Barouni RM,Banos A,Sormendi S,Polyzos A,Xilouri M,Wielockx B,Gogas H,Verginis P

14-0041 was used in Immunofluorescence in immunohistochemistry on frozen tissues to identify autophagy as a crucial pathway for myeloid-derived suppressor cell-mediated suppression of antitumour immunity.

Fri Aug 31 00:00:00 EDT 2018

The E3 ligase VHL controls alveolar macrophage function via metabolic-epigenetic regulation.

The Journal of experimental medicine

Zhang W,Li Q,Li D,Li J,Aki D,Liu YC

14-0041 was used in Flow cytometry/Cell sorting to show VHL regulates alveolar macrophages and acts as a crucial egulatory factor in lung inflammation and fibrosis.

Mon Dec 03 00:00:00 EST 2018

Pre-existing Immunity to Oncolytic Virus Potentiates Its Immunotherapeutic Efficacy.

Molecular therapy : the journal of the American Society of Gene Therapy

Ricca JM,Oseledchyk A,Walther T,Liu C,Mangarin L,Merghoub T,Wolchok JD,Zamarin D

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Wed Apr 04 00:00:00 EDT 2018

Long-term health in recipients of transplanted in vitro propagated spermatogonial stem cells.

Human reproduction (Oxford, England)

Mulder CL,Catsburg LAE,Zheng Y,de Winter-Korver CM,van Daalen SKM,van Wely M,Pals S,Repping S,van Pelt AMM

14-0041 was used in functional experiments to study, using a mouse model, the long-term health of recipients of Spermatogonial stem cell autotransplantation (SSCT), in which stem cells were propagated in vitro.

Mon Jan 01 00:00:00 EST 2018

MicroRNA-126 deficiency enhanced the activation and function of CD4⁺ T cells by elevating IRS-1 pathway.

Clinical and experimental immunology

Chu F,Hu Y,Zhou Y,Guo M,Lu J,Zheng W,Xu H,Zhao J,Xu L

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Thu Feb 01 00:00:00 EST 2018

STAT5B: A Differential Regulator of the Life and Death of CD4⁺ Effector Memory T Cells.

Journal of immunology (Baltimore, Md. : 1950)

Majri SS,Fritz JM,Villarino AV,Zheng L,Kanellopoulou C,Chaigne-Delalande B,Grönholm J,Niemela JE,Afzali B,Biancalana M,Pittaluga S,Sun A,Cohen JL,Holland SM,O'Shea JJ,Uzel G,Lenardo MJ

14-0041 was used in Flow cytometry/Cell sorting to show that STAT5B, a transcription factor downstream of multiple cytokines involved in RICD, is essential for triggering apoptosis of mouse and human TEM cells, and that altered STAT5B transcriptional activity drives immunodeficiency and dysfunction.

Mon Jan 01 00:00:00 EST 2018

Impact of hyperglycemia on autoimmune pancreatitis and regulatory T-cells.

World journal of gastroenterology

Müller-Graff FT,Fitzner B,Jaster R,Vollmar B,Zechner D

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Sat Jul 28 00:00:00 EDT 2018

Radiation Therapy Combined with Cowpea Mosaic Virus Nanoparticle in Situ Vaccination Initiates Immune-Mediated Tumor Regression.

ACS omega

Patel R,Czapar AE,Fiering S,Oleinick NL,Steinmetz NF

14-0041 was used in Immunohistochemistry to test a novel immunotherapeutic approach utilising combination radiation therapy with immunostimulatory cowpea mosaic virus in a preclinical syngeneic mouse model of ovarian carcinoma.

Mon Apr 30 00:00:00 EDT 2018

Baicalin Downregulates RLRs Signaling Pathway to Control Influenza A Virus Infection and Improve the Prognosis.

Evidence-based complementary and alternative medicine : eCAM

Pang P,Zheng K,Wu S,Xu H,Deng L,Shi Y,Chen X

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Thu Oct 01 00:00:00 EDT 2020

Sipa1 deficiency unleashes a host-immune mechanism eradicating chronic myelogenous leukemia-initiating cells.

Nature communications

Xu Y,Ikeda S,Sumida K,Yamamoto R,Tanaka H,Minato N

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Fri Mar 02 00:00:00 EST 2018

Pyruvate dehydrogenase complex stimulation promotes immunometabolic homeostasis and sepsis survival.

JCI insight

McCall CE,Zabalawi M,Liu T,Martin A,Long DL,Buechler NL,Arts RJW,Netea M,Yoza BK,Stacpoole PW,Vachharajani V

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Thu Aug 09 00:00:00 EDT 2018

Inhibition of Rspo-Lgr4 Facilitates Checkpoint Blockade Therapy by Switching Macrophage Polarization.

Cancer research

Tan B,Shi X,Zhang J,Qin J,Zhang N,Ren H,Qian M,Siwko S,Carmon K,Liu Q,Han H,Du B,Liu M

14-0041-82 was used in Flow cytometry/Cell sorting to identify Lgr4 as a critical switch in TAMs polarization and a potentially good drug target for cancer immune therapy.

Sat Sep 01 00:00:00 EDT 2018

Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation.

eLife

Lian G,Gnanaprakasam JR,Wang T,Wu R,Chen X,Liu L,Shen Y,Yang M,Yang J,Chen Y,Vasiliou V,Cassel TA,Green DR,Liu Y,Fan TW,Wang R

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Mon Sep 10 00:00:00 EDT 2018

Establishment of regulatory elements during erythro-megakaryopoiesis identifies hematopoietic lineage-commitment points.

Epigenetics & chromatin

Heuston EF,Keller CA,Lichtenberg J,Giardine B,Anderson SM,Hardison RC,Bodine DM

14-0041-82 was used in Flow Cytometry to demonstrate that megakaryopoietic profiles are established early in haematopoiesis and are present in the majority of the haematopoietic progenitor population.

Mon May 28 00:00:00 EDT 2018

A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors.

Nature communications

Wang T,Wang D,Yu H,Feng B,Zhou F,Zhang H,Zhou L,Jiao S,Li Y

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Wed Apr 18 00:00:00 EDT 2018

Photosensitizer Micelles Together with IDO Inhibitor Enhance Cancer Photothermal Therapy and Immunotherapy.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Peng J,Xiao Y,Li W,Yang Q,Tan L,Jia Y,Qu Y,Qian Z

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Tue May 01 00:00:00 EDT 2018

A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment.

eLife

Ng KK,Yui MA,Mehta A,Siu S,Irwin B,Pease S,Hirose S,Elowitz MB,Rothenberg EV,Kueh HY

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Tue Nov 20 00:00:00 EST 2018

Microglia prevent peripheral immune cell invasion and promote an anti-inflammatory environment in the brain of APP-PS1 transgenic mice.

Journal of neuroinflammation

Unger MS,Schernthaner P,Marschallinger J,Mrowetz H,Aigner L

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Fri Sep 21 00:00:00 EDT 2018

The Potential Role of a Soluble γ-Chain Cytokine Receptor as a Regulator of IL-7-Induced Lymphoproliferative Disorders.

International journal of molecular sciences

Kim G,Jo Y,Lee B,Ali LA,Lee B,Hong C

14-0041 was used in Flow cytometry/Cell sorting to determine whether IL-7-induced lymphoproliferative disorders could be regulated using a soluble γ-chain cytokine receptor.

Sun Oct 28 00:00:00 EDT 2018

Macrophage Depletion Protects against Cigarette Smoke-Induced Inflammatory Response in the Mouse Colon and Lung.

Frontiers in physiology

Lim D,Kim W,Lee C,Bae H,Kim J

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Wed Sep 30 00:00:00 EDT 2020

TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival.

Nature communications

Zhu L,Xie X,Zhang L,Wang H,Jie Z,Zhou X,Shi J,Zhao S,Zhang B,Cheng X,Sun SC

14-0041 was used in Flow cytometry/Cell sorting to study the mechanism of IL-15 function in autophagy and natural killer cell survival.

Wed Jul 18 00:00:00 EDT 2018

Plasmodium co-infection protects against chikungunya virus-induced pathologies.

Nature communications

Teo TH,Lum FM,Ghaffar K,Chan YH,Amrun SN,Tan JJL,Lee CYP,Chua TK,Carissimo G,Lee WWL,Claser C,Rajarethinam R,Rénia L,Ng LFP

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Tue Sep 25 00:00:00 EDT 2018

Apigenin suppresses PD-L1 expression in melanoma and host dendritic cells to elicit synergistic therapeutic effects.

Journal of experimental & clinical cancer research : CR

Xu L,Zhang Y,Tian K,Chen X,Zhang R,Mu X,Wu Y,Wang D,Wang S,Liu F,Wang T,Zhang J,Liu S,Zhang Y,Tu C,Liu H

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Mon Oct 29 00:00:00 EDT 2018

Microbiota Reconstitution Does Not Cause Bone Loss in Germ-Free Mice.

mSphere

Quach D,Collins F,Parameswaran N,McCabe L,Britton RA

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Wed Nov 20 00:00:00 EST 2019

Store-Operated Ca²⁺ Entry Controls Clonal Expansion of T Cells through Metabolic Reprogramming.

Immunity

Vaeth M,Maus M,Klein-Hessling S,Freinkman E,Yang J,Eckstein M,Cameron S,Turvey SE,Serfling E,Berberich-Siebelt F,Possemato R,Feske S

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Tue Oct 17 00:00:00 EDT 2017

Caveolin-1-dependent nanoscale organization of the BCR regulates B cell tolerance.

Nature immunology

Minguet S,Kläsener K,Schaffer AM,Fiala GJ,Osteso-Ibánez T,Raute K,Navarro-Lérida I,Hartl FA,Seidl M,Reth M,Del Pozo MA

14-0041 was used in Flow cytometry/Cell sorting to study the role of Caveolin-1 in controlling the distribution of nanoclusters of isotype-specific B cell antigen receptors on the surface of B cells.

Sun Oct 01 00:00:00 EDT 2017

A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer.

The Journal of clinical investigation

Berlato C,Khan MN,Schioppa T,Thompson R,Maniati E,Montfort A,Jangani M,Canosa M,Kulbe H,Hagemann UB,Duncan AR,Fletcher L,Wilkinson RW,Powles T,Quezada SA,Balkwill FR

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2017

Membrane-organizing protein moesin controls Treg differentiation and antitumor immunity via TGF-β signaling.

The Journal of clinical investigation

Ansa-Addo EA,Zhang Y,Yang Y,Hussey GS,Howley BV,Salem M,Riesenberg B,Sun S,Rockey DC,Karvar S,Howe PH,Liu B,Li Z

14-0041 was used in Flow cytometry/Cell sorting to investigate whether moesin plays a role during the generation of TGF-β-induced Tregs, showing that it controls Treg differentiation and antitumor immunity.

Mon Apr 03 00:00:00 EDT 2017

LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis.

The Journal of experimental medicine

Xu X,Han L,Zhao G,Xue S,Gao Y,Xiao J,Zhang S,Chen P,Wu ZY,Ding J,Hu R,Wei B,Wang H

14-0041 was used in Flow cytometry/Cell sorting to demonstrate LRCH1 as a novel effector to restrain PKCα-DOCK8-Cdc42 module-induced T cell migration and ameliorate EAE.

Sun Jan 01 00:00:00 EST 2017

Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.

The Journal of experimental medicine

Miao T,Symonds ALJ,Singh R,Symonds JD,Ogbe A,Omodho B,Zhu B,Li S,Wang P

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Mon Jun 05 00:00:00 EDT 2017

Mast cells acquire MHCII from dendritic cells during skin inflammation.

The Journal of experimental medicine

Dudeck J,Medyukhina A,Fröbel J,Svensson CM,Kotrba J,Gerlach M,Gradtke AC,Schröder B,Speier S,Figge MT,Dudeck A

14-0041 was used in Flow cytometry/Cell sorting to identify an innate intercellular communication arming resident mast cells with key dendritic cell(DC) functions that might contribute to the acute defence potential during critical periods of migration-based DC absence.

Mon Dec 04 00:00:00 EST 2017

MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation.

The Journal of experimental medicine

Singh PB,Pua HH,Happ HC,Schneider C,von Moltke J,Locksley RM,Baumjohann D,Ansel KM

14-0041 was used in Flow cytometry/Cell sorting to establish the physiological requirements for miRNAs in ILC2 homeostasis and immune function ans compare the global miRNA repertoire of resting and activated ILC2s and T helper type 2 cells.

Mon Dec 04 00:00:00 EST 2017

Dissection of SAP-dependent and SAP-independent SLAM family signaling in NKT cell development and humoral immunity.

The Journal of experimental medicine

Chen S,Cai C,Li Z,Liu G,Wang Y,Blonska M,Li D,Du J,Lin X,Yang M,Dong Z

14-0041-82 was used in Flow Cytometry to examine NKT cell development and humoral immunity in mice completely deficient in SFR.

Wed Feb 01 00:00:00 EST 2017

Oncolytic Adenovirus and Tumor-Targeting Immune Modulatory Therapy Improve Autologous Cancer Vaccination.

Cancer research

Jiang H,Rivera-Molina Y,Gomez-Manzano C,Clise-Dwyer K,Bover L,Vence LM,Yuan Y,Lang FF,Toniatti C,Hossain MB,Fueyo J

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Sat Jul 15 00:00:00 EDT 2017

Deficiency of transcription factor RelB perturbs myeloid and DC development by hematopoietic-extrinsic mechanisms.

Proceedings of the National Academy of Sciences of the United States of America

Briseño CG,Gargaro M,Durai V,Davidson JT,Theisen DJ,Anderson DA,Novack DV,Murphy TL,Murphy KM

14-0041 was used in Flow cytometry/Cell sorting to suggest that there is an unrecognized but critical role for RelB within the nonhematopoietic niche that controls normal myelopoiesis.

Tue Apr 11 00:00:00 EDT 2017

Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease.

Proceedings of the National Academy of Sciences of the United States of America

Pishesha N,Bilate AM,Wibowo MC,Huang NJ,Li Z,Deshycka R,Bousbaine D,Li H,Patterson HC,Dougan SK,Maruyama T,Lodish HF,Ploegh HL

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Tue Mar 21 00:00:00 EDT 2017

Activated T Lymphocytes are Essential Drivers of Pathological Remodeling in Ischemic Heart Failure.

Circulation. Heart failure

Bansal SS,Ismahil MA,Goel M,Patel B,Hamid T,Rokosh G,Prabhu SD

14-0041 was used in Immunohistochemistry to identify cardiac and splenic T cells in HF induce cardiac injury and how we can target specific leukocytes populations in immunomodulation.

Wed Mar 01 00:00:00 EST 2017

The Spontaneous Autoimmune Neuromyopathy in ICOSL^-/- NOD Mice Is CD4⁺ T-Cell and Interferon-γ Dependent.

Frontiers in immunology

Briet C,Bourdenet G,Rogner UC,Becourt C,Tardivel I,Drouot L,Arnoult C,do Rego JC,Prevot N,Massaad C,Boyer O,Boitard C

14-0041 was used in Immunohistochemistry to characterise the ICOSL-/-NOD model.

Wed Nov 20 00:00:00 EST 2019

An Antigen-Presenting and Apoptosis-Inducing Polymer Microparticle Prolongs Alloskin Graft Survival by Selectively and Markedly Depleting Alloreactive CD8⁺ T Cells.

Frontiers in immunology

Wang W,Shahzad KA,Li M,Zhang A,Zhang L,Xu T,Wan X,Shen C

14-0041 was used in Immunohistochemistry to document the high potential of PLGA MP-based KaAPCs as a novel antigen-specific immunotherapy for allograft rejection and autoimmune disorder.

Wed Nov 20 00:00:00 EST 2019

Betulin from Hedyotis hedyotidea ameliorates concanavalin A-induced and T cell-mediated autoimmune hepatitis in mice.

Acta pharmacologica Sinica

Zhou YQ,Weng XF,Dou R,Tan XS,Zhang TT,Fang JB,Wu XW

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Wed Feb 01 00:00:00 EST 2017

Minimally manipulated murine regulatory T cells purified by reversible Fab Multimers are potent suppressors for adoptive T-cell therapy.

European journal of immunology

Mohr F,Fischer JC,Nikolaus M,Stemberger C,Dreher S,Verschoor A,Haas T,Poeck H,Busch DH

14-0041 was used in Flow cytometry/Cell sorting to demonstrate how reversible Fab multimer-based murine regulatory T cell (Treg) isolation can prevent conventional antibody label-induced interferences, and offer higher potency when applied to Treg-based therapies.

Fri Dec 01 00:00:00 EST 2017

NCR1-deficiency diminishes the generation of protective murine cytomegalovirus antibodies by limiting follicular helper T-cell maturation.

European journal of immunology

Miletic A,Lenartic M,Popovic B,Brizic I,Trsan T,Miklic K,Mandelboim O,Krmpotic A,Jonjic S

14-0041 was used in Flow cytometry/Cell sorting to provide evidence for the role of NCR1 in antibody response to mouse cytomegalovirus infection.

Fri Sep 01 00:00:00 EDT 2017

Thymidine Kinase-Negative Herpes Simplex Virus 1 Can Efficiently Establish Persistent Infection in Neural Tissues of Nude Mice.

Journal of virology

Huang CY,Yao HW,Wang LC,Shen FH,Hsu SM,Chen SH

14-0041 was used in Flow cytometry/Cell sorting to investigate the significance of viral thymidine kinase and host T cells for the persistence of Herpes simplex virus-1 in neural tissues.

Wed Feb 15 00:00:00 EST 2017

Cornea lymphatics drive the CD8⁺ T-cell response to herpes simplex virus-1.

Immunology and cell biology

Gurung HR,Carr MM,Carr DJ

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Sun Jan 01 00:00:00 EST 2017

ADAR1 deletion induces NFκB and interferon signaling dependent liver inflammation and fibrosis.

RNA biology

Ben-Shoshan SO,Kagan P,Sultan M,Barabash Z,Dor C,Jacob-Hirsch J,Harmelin A,Pappo O,Marcu-Malina V,Ben-Ari Z,Amariglio N,Rechavi G,Goldstein I,Safran M

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Thu May 04 00:00:00 EDT 2017

Protection against Streptococcus pneumoniae Invasive Pathogenesis by a Protein-Based Vaccine Is Achieved by Suppression of Nasopharyngeal Bacterial Density during Influenza A Virus Coinfection.

Infection and immunity

Khan MN,Xu Q,Pichichero ME

14-0041 was used in Flow cytometry/Cell sorting to show an outcome with regard to prevention of invasive S. pneumoniae pathogenesis with a protein vaccine similar to that which occurs with a glycoconjugate vaccine despite a less robust reduction in nasopharynx bacterial density.

Wed Feb 01 00:00:00 EST 2017

Adeno-associated virus serotype rh.10 displays strong muscle tropism following intraperitoneal delivery.

Scientific reports

Ai J,Li J,Gessler DJ,Su Q,Wei Q,Li H,Gao G

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Immunofluorescence

Mon Jan 09 00:00:00 EST 2017

Shifts in the Gut Microbiota Composition Due to Depleted Bone Marrow Beta Adrenergic Signaling Are Associated with Suppressed Inflammatory Transcriptional Networks in the Mouse Colon.

Frontiers in physiology

Yang T,Ahmari N,Schmidt JT,Redler T,Arocha R,Pacholec K,Magee KL,Malphurs W,Owen JL,Krane GA,Li E,Wang GP,Vickroy TW,Raizada MK,Martyniuk CJ,Zubcevic J

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Immunofluorescence

Thu Oct 01 00:00:00 EDT 2020

Heavy Chain-Hyaluronan/Pentraxin 3 from Amniotic Membrane Suppresses Inflammation and Scarring in Murine Lacrimal Gland and Conjunctiva of Chronic Graft-versus-Host Disease.

Scientific reports

Ogawa Y,He H,Mukai S,Imada T,Nakamura S,Su CW,Mahabole M,Tseng SC,Tsubota K

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Immunohistochemistry

Mon Feb 06 00:00:00 EST 2017

Location of tumor affects local and distant immune cell type and number.

Immunity, inflammation and disease

Hensel JA,Khattar V,Ashton R,Lee C,Siegal GP,Ponnazhagan S

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2017

Alternative activation generates IL-10 producing type 2 innate lymphoid cells.

Nature communications

Seehus CR,Kadavallore A,Torre B,Yeckes AR,Wang Y,Tang J,Kaye J

14-0041 was used in Functional assays to demonstrate the generation of a previously unappreciated IL-10 producing type 2 innate lymphoid cell effector cell population.

Fri Dec 01 00:00:00 EST 2017

Human amnion cells reverse acute and chronic pulmonary damage in experimental neonatal lung injury.

Stem cell research & therapy

Zhu D,Tan J,Maleken AS,Muljadi R,Chan ST,Lau SN,Elgass K,Leaw B,Mockler J,Chambers D,Leeman KT,Kim CF,Wallace EM,Lim R

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Fri Nov 10 00:00:00 EST 2017

A robust in vitro model for trans-lymphatic endothelial migration.

Scientific reports

Xiong Y,Brinkman CC,Famulski KS,Mongodin EF,Lord CJ,Hippen KL,Blazar BR,Bromberg JS

14-0041 was used in Flow cytometry/Cell sorting to establish an in vitro system to evaluate lymphatic Trans-endothelial migration for various cell types across primary mouse and human lymphatic endothelial cells.

Tue May 09 00:00:00 EDT 2017

Relevance of CCL3/CCR5 axis in oral carcinogenesis.

Oncotarget

da Silva JM,Moreira Dos Santos TP,Sobral LM,Queiroz-Junior CM,Rachid MA,Proudfoot AEI,Garlet GP,Batista AC,Teixeira MM,Leopoldino AM,Russo RC,Silva TA

14-0041 was used in Immunohistochemistry to show how, in oral carcinogenesis, CCL3/CCR5 axis has pro-tumourigenic effects by inflammatory and angiogenic pathway induction and recruitment of eosinophils.

Tue Aug 01 00:00:00 EDT 2017

MSC-derived Extracellular Vesicles Attenuate Immune Responses in Two Autoimmune Murine Models: Type 1 Diabetes and Uveoretinitis.

Stem cell reports

Shigemoto-Kuroda T,Oh JY,Kim DK,Jeong HJ,Park SY,Lee HJ,Park JW,Kim TW,An SY,Prockop DJ,Lee RH

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Tue May 09 00:00:00 EDT 2017

Traditional Herbal Medicine-Derived Sulforaphene LFS-01 Reverses Colitis in Mice by Selectively Altering the Gut Microbiota and Promoting Intestinal Gamma-Delta T Cells.

Frontiers in pharmacology

Li M,Gao J,Tang Y,Liu M,Wu S,Qu K,Long X,Li H,Liu M,Liu Y,Yuan J,Mao L,Liu Y,Zheng X,Wang E,Wang J,Yang Y

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Wed Sep 30 00:00:00 EDT 2020

Rottlerin as a therapeutic approach in psoriasis: Evidence from in vitro and in vivo studies.

PloS one

Min M,Yan BX,Wang P,Landeck L,Chen JQ,Li W,Cai SQ,Zheng M,Man XY

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Tue Jan 16 00:00:00 EST 2018

Compensatory upregulation of PD-1, LAG-3, and CTLA-4 limits the efficacy of single-agent checkpoint blockade in metastatic ovarian cancer.

Oncoimmunology

Huang RY,Francois A,McGray AR,Miliotto A,Odunsi K

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Tue Jan 12 00:00:00 EST 2021

Autophagy is a signature of a signaling network that maintains hematopoietic stem cells.

PloS one

Nguyen-McCarty M,Klein PS

14-0041 was used in Flow cytometry/Cell sorting to identify the downstream effectors of mTORC1 in hematopoietic stem cells.

Fri Sep 15 00:00:00 EDT 2017

Human and Mouse Hematopoietic Stem Cells Are a Depot for Dormant Mycobacterium tuberculosis.

PloS one

Tornack J,Reece ST,Bauer WM,Vogelzang A,Bandermann S,Zedler U,Stingl G,Kaufmann SH,Melchers F

14-0041-82 was used in Flow Cytometry to conclude that LT-pHSCs, together with MSCs of Mtb-infected humans and mice serve as a hitherto unappreciated quiescent cellular depot for Mtb during latent TB infection.

Tue Sep 05 00:00:00 EDT 2017

Irgm1 coordinately regulates autoimmunity and host defense at select mucosal surfaces.

JCI insight

Azzam KM,Madenspacher JH,Cain DW,Lai L,Gowdy KM,Rai P,Janardhan K,Clayton N,Cunningham W,Jensen H,Patel PS,Kearney JF,Taylor GA,Fessler MB

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Thu Aug 17 00:00:00 EDT 2017

Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity.

Nature communications

Zamarin D,Holmgaard RB,Ricca J,Plitt T,Palese P,Sharma P,Merghoub T,Wolchok JD,Allison JP

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Mon Feb 13 00:00:00 EST 2017

A Multistage Subunit Vaccine Effectively Protects Mice Against Primary Progressive Tuberculosis, Latency and Reactivation.

EBioMedicine

Ma J,Teng X,Wang X,Fan X,Wu Y,Tian M,Zhou Z,Li L

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Tue Aug 01 00:00:00 EDT 2017

CD4 T Cell Dependent Colitis Exacerbation Following Re-Exposure of Mycobacterium avium ssp. paratuberculosis.

Frontiers in cellular and infection microbiology

Suwandi A,Bargen I,Pils MC,Krey M,Zur Lage S,Singh AK,Basler T,Falk CS,Seidler U,Hornef MW,Goethe R,Weiss S

14-0041 was used in Immunohistochemistry to reveal the specific ability of MAP to aggravate intestinal inflammation and clinical symptoms.

Tue Sep 19 00:00:00 EDT 2017

Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome.

Cell

Chudnovskiy A,Mortha A,Kana V,Kennard A,Ramirez JD,Rahman A,Remark R,Mogno I,Ng R,Gnjatic S,Amir ED,Solovyov A,Greenbaum B,Clemente J,Faith J,Belkaid Y,Grigg ME,Merad M

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Thu Oct 06 00:00:00 EDT 2016

Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation.

Nature immunology

Monticelli LA,Buck MD,Flamar AL,Saenz SA,Tait Wojno ED,Yudanin NA,Osborne LC,Hepworth MR,Tran SV,Rodewald HR,Shah H,Cross JR,Diamond JM,Cantu E,Christie JD,Pearce EL,Artis D

14-0041 was used in Flow cytometry/Cell sorting to identify Arg1 as a key regulator of group 2 innate lymphoid cell bioenergetics that control proliferative capacity and pro-inflammatory functions.

Wed Jun 01 00:00:00 EDT 2016

Foxp3 and Toll-like receptor signaling balance T_reg cell anabolic metabolism for suppression.

Nature immunology

Gerriets VA,Kishton RJ,Johnson MO,Cohen S,Siska PJ,Nichols AG,Warmoes MO,de Cubas AA,MacIver NJ,Locasale JW,Turka LA,Wells AD,Rathmell JC

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Thu Dec 01 00:00:00 EST 2016

Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart Failure.

Circulation research

Sager HB,Hulsmans M,Lavine KJ,Moreira MB,Heidt T,Courties G,Sun Y,Iwamoto Y,Tricot B,Khan OF,Dahlman JE,Borodovsky A,Fitzgerald K,Anderson DG,Weissleder R,Libby P,Swirski FK,Nahrendorf M

14-0041 was used in Flow cytometry/Cell sorting to elucidate the origin and roles of macrophages in the post-myocardial infarction remodelling of nonischaemic remote myocardium.

Fri Sep 16 00:00:00 EDT 2016

Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity.

The Journal of clinical investigation

Massaad MJ,Zhou J,Tsuchimoto D,Chou J,Jabara H,Janssen E,Glauzy S,Olson BG,Morbach H,Ohsumi TK,Schmitz K,Kyriacos M,Kane J,Torisu K,Nakabeppu Y,Notarangelo LD,Chouery E,Megarbane A,Kang PB,Al-Idrissi E,Aldhekri H,Meffre E,Mizui M,Tsokos GC,Manis JP,Al-Herz W,Wallace SS,Geha RS

14-0041 was used in Flow cytometry/Cell sorting to investigate alterations in immune cell apoptosis during autoimmunity, showing that deficiency in NEIL3 drives increased predisposition to autoimmunity.

Tue Nov 01 00:00:00 EDT 2016

pDC therapy induces recovery from EAE by recruiting endogenous pDC to sites of CNS inflammation.

Journal of autoimmunity

Duraes FV,Lippens C,Steinbach K,Dubrot J,Brighouse D,Bendriss-Vermare N,Issazadeh-Navikas S,Merkler D,Hugues S

14-0041 was used in Flow cytometry/Cell sorting to investigate novel pDC-based cell therapies in autoimmune diseases, aiming at specifically modulating pathogenic cells that induce and sustain autoimmune inflammation.

Mon Feb 01 00:00:00 EST 2016

Dysbiosis-induced IL-33 contributes to impaired antiviral immunity in the genital mucosa.

Proceedings of the National Academy of Sciences of the United States of America

Oh JE,Kim BC,Chang DH,Kwon M,Lee SY,Kang D,Kim JY,Hwang I,Yu JW,Nakae S,Lee HK

14-0041 was used in Flow cytometry/Cell sorting to provide insight into the mechanisms of homeostasis maintained by commensal bacteria, and reveal a deleterious consequence of dysbiosis in antiviral immune defense.

Tue Feb 09 00:00:00 EST 2016

Macrophages transfer antigens to dendritic cells by releasing exosomes containing dead-cell-associated antigens partially through a ceramide-dependent pathway to enhance CD4(+) T-cell responses.

Immunology

Xu Y,Liu Y,Yang C,Kang L,Wang M,Hu J,He H,Song W,Tang H

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Sat Oct 01 00:00:00 EDT 2016

p(⁷⁰S⁶K¹) in the TORC1 pathway is essential for the differentiation of Th17 Cells, but not Th1, Th2, or Treg cells in mice.

European journal of immunology

Sasaki CY,Chen G,Munk R,Eitan E,Martindale J,Longo DL,Ghosh P

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Fri Jan 01 00:00:00 EST 2016

Multispectral Imaging of T and B Cells in Murine Spleen and Tumor.

Journal of immunology (Baltimore, Md. : 1950)

Feng Z,Jensen SM,Messenheimer DJ,Farhad M,Neuberger M,Bifulco CB,Fox BA

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Immunofluorescence

Sun May 01 00:00:00 EDT 2016

Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency.

Journal of immunology (Baltimore, Md. : 1950)

Menendez CM,Jinkins JK,Carr DJ

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Mon Aug 15 00:00:00 EDT 2016

Blood Stem Cell Activity Is Arrested by Th1-Mediated Injury Preventing Engraftment following Nonmyeloablative Conditioning.

Journal of immunology (Baltimore, Md. : 1950)

Müller AM,Florek M,Kohrt HE,Küpper NJ,Filatenkov A,Linderman JA,Hadeiba H,Negrin RS,Shizuru JA

14-0041 was used in Flow cytometry/Cell sorting to shed new light on the effects of CD4+ T cells on HSC biology.

Tue Nov 15 00:00:00 EST 2016

Deletion of 5-Lipoxygenase in the Tumor Microenvironment Promotes Lung Cancer Progression and Metastasis through Regulating T Cell Recruitment.

Journal of immunology (Baltimore, Md. : 1950)

Poczobutt JM,Nguyen TT,Hanson D,Li H,Sippel TR,Weiser-Evans MC,Gijon M,Murphy RC,Nemenoff RA

14-0041 was used in Flow cytometry/Cell sorting to reveal an antitumorigenic role for 5-LO products in the microenvironment during lung cancer progression through T cell regulation.

Fri Jan 15 00:00:00 EST 2016

Exaggerated IL-15 and Altered Expression of foxp3+ Cell-Derived Cytokines Contribute to Enhanced Colitis in Nlrp3-/- Mice.

Mediators of inflammation

Hirota SA,Ueno A,Tulk SE,Becker HM,Schenck LP,Potentier MS,Li Y,Ghosh S,Muruve DA,MacDonald JA,Beck PL

14-0041 was used in Flow cytometry/Cell sorting to suggest that the NLRP3 inflammasome can regulate intestinal inflammation through noncanonical mechanisms.

Mon Jun 05 00:00:00 EDT 2017

Rapamycin ameliorates CCl4-induced liver fibrosis in mice through reciprocal regulation of the Th17/Treg cell balance.

Molecular medicine reports

Gu L,Deng WS,Sun XF,Zhou H,Xu Q

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Mon Aug 01 00:00:00 EDT 2016

PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL.

Biology open

Carofino BL,Ayanga B,Tracey LJ,Brooke-Bisschop T,Justice MJ

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Sun May 15 00:00:00 EDT 2016

Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration.

Nature communications

Brinkman CC,Iwami D,Hritzo MK,Xiong Y,Ahmad S,Simon T,Hippen KL,Blazar BR,Bromberg JS

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Tue Jun 21 00:00:00 EDT 2016

Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis.

Nature communications

Ruhland MK,Loza AJ,Capietto AH,Luo X,Knolhoff BL,Flanagan KC,Belt BA,Alspach E,Leahy K,Luo J,Schaffer A,Edwards JR,Longmore G,Faccio R,DeNardo DG,Stewart SA

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Wed Jun 08 00:00:00 EDT 2016

In vitro Differentiation of Murine Innate Lymphoid Cells from Common Lymphoid Progenitor Cells.

Bio-protocol

Seehus C,Kaye J

14004182 was used in flow cytometry to detail how to obtain innate lymphoid cells from isolated common lymphoid progenitors

Sun Mar 20 00:00:00 EDT 2016

Interleukin-10 deficiency impairs regulatory T cell-derived neuropilin-1 functions and promotes Th1 and Th17 immunity.

Scientific reports

Wang S,Gao X,Shen G,Wang W,Li J,Zhao J,Wei YQ,Edwards CK

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Thu Apr 14 00:00:00 EDT 2016

NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells.

Nature communications

Alrefai H,Muhammad K,Rudolf R,Pham DA,Klein-Hessling S,Patra AK,Avots A,Bukur V,Sahin U,Tenzer S,Goebeler M,Kerstan A,Serfling E

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Wed May 25 00:00:00 EDT 2016

Epigallocatechin-3-gallate (EGCG) inhibits imiquimod-induced psoriasis-like inflammation of BALB/c mice.

BMC complementary and alternative medicine

Zhang S,Liu X,Mei L,Wang H,Fang F

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Wed Aug 31 00:00:00 EDT 2016

Flagellin is a strong vaginal adjuvant of a therapeutic vaccine for genital cancer.

Oncoimmunology

Lee SE,Hong SH,Verma V,Lee YS,Duong TN,Jeong K,Uthaman S,Sung YC,Lee JT,Park IK,Min JJ,Rhee JH

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2016

Essential Contribution of CD4+ T Cells to Antigen-Induced Nasal Hyperresponsiveness in Experimental Allergic Rhinitis.

PloS one

Nishimura T,Kaminuma O,Saeki M,Kitamura N,Matsuoka K,Yonekawa H,Mori A,Hiroi T

14-0041 was used in Functional assays to demonstrate that CD4+ T-cells are crucial in the pathogenesis of allergic rhinitis via induction of nasal hyperresponsiveness.

Mon Jul 04 00:00:00 EDT 2016

A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms.

Cell reports

Choi IY,Piccio L,Childress P,Bollman B,Ghosh A,Brandhorst S,Suarez J,Michalsen A,Cross AH,Morgan TE,Wei M,Paul F,Bock M,Longo VD

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Tue Jun 07 00:00:00 EDT 2016

Conditions for the generation of cytotoxic CD4(+) Th cells that enhance CD8(+) CTL-mediated tumor regression.

Clinical & translational immunology

Li K,Baird M,Yang J,Jackson C,Ronchese F,Young S

14-0041 was used in Flow cytometry/Cell sorting to provide valuable data for further research into in vitro expansion of CD4(+) Th1-like cells, with potential applications to cancer treatment involving ACT.

Mon Aug 01 00:00:00 EDT 2016

TNF-Mediated Restriction of Arginase 1 Expression in Myeloid Cells Triggers Type 2 NO Synthase Activity at the Site of Infection.

Cell reports

Schleicher U,Paduch K,Debus A,Obermeyer S,König T,Kling JC,Ribechini E,Dudziak D,Mougiakakos D,Murray PJ,Ostuni R,Körner H,Bogdan C

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Tue May 03 00:00:00 EDT 2016

Non-canonical antagonism of PI3K by the kinase Itpkb delays thymocyte β-selection and renders it Notch-dependent.

eLife

Westernberg L,Conche C,Huang YH,Rigaud S,Deng Y,Siegemund S,Mukherjee S,Nosaka L,Das J,Sauer K

14-0041 was used in Flow cytometry/Cell sorting to elucidate the mechanisms underlying the establishment of the Notch-dependent nature of β-selection.

Thu Feb 11 00:00:00 EST 2016

Fas/CD95 prevents autoimmunity independently of lipid raft localization and efficient apoptosis induction.

Nature communications

Cruz AC,Ramaswamy M,Ouyang C,Klebanoff CA,Sengupta P,Yamamoto TN,Meylan F,Thomas SK,Richoz N,Eil R,Price S,Casellas R,Rao VK,Lippincott-Schwartz J,Restifo NP,Siegel RM

14-0041 was used in Functional assays to elucidate how palmitoylation defects in the Fas/CD95 receptor impact primary immune cells.

Fri Dec 23 00:00:00 EST 2016

Fas/CD95 prevents autoimmunity independently of lipid raft localization and efficient apoptosis induction.

Nature communications

Cruz AC,Ramaswamy M,Ouyang C,Klebanoff CA,Sengupta P,Yamamoto TN,Meylan F,Thomas SK,Richoz N,Eil R,Price S,Casellas R,Rao VK,Lippincott-Schwartz J,Restifo NP,Siegel RM

14-0041 was used in Functional assays to elucidate how palmitoylation defects in the Fas/CD95 receptor impact primary immune cells.

Fri Dec 23 00:00:00 EST 2016

PD-1 pathway-mediated regulation of islet-specific CD4⁺ T cell subsets in autoimmune diabetes.

Immunoendocrinology (Houston, Tex.)

Martinov T,Spanier JA,Pauken KE,Fife BT

14-0041 was used in Flow cytometry/Cell sorting to understand the role of PD-1 in maintaining islet-specific tolerance in diabetes-resistant strains.

Wed Mar 30 00:00:00 EDT 2022

Diet-dependent, microbiota-independent regulation of IL-10-producing lamina propria macrophages in the small intestine.

Scientific reports

Ochi T,Feng Y,Kitamoto S,Nagao-Kitamoto H,Kuffa P,Atarashi K,Honda K,Teitelbaum DH,Kamada N

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Wed Jun 15 00:00:00 EDT 2016

CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.

Nature

Huang YH,Zhu C,Kondo Y,Anderson AC,Gandhi A,Russell A,Dougan SK,Petersen BS,Melum E,Pertel T,Clayton KL,Raab M,Chen Q,Beauchemin N,Yazaki PJ,Pyzik M,Ostrowski MA,Glickman JN,Rudd CE,Ploegh HL,Franke A,Petsko GA,Kuchroo VK,Blumberg RS

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Thu Jan 15 00:00:00 EST 2015

Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy.

Nature biotechnology

Kim J,Li WA,Choi Y,Lewin SA,Verbeke CS,Dranoff G,Mooney DJ

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Thu Jan 01 00:00:00 EST 2015

Phosphatase Wip1 controls antigen-independent B-cell development in a p53-dependent manner.

Blood

Yi W,Hu X,Chen Z,Liu L,Tian Y,Chen H,Cong YS,Yang F,Zhang L,Rudolph KL,Zhang Z,Zhao Y,Ju Z

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Thu Jul 30 00:00:00 EDT 2015

Bcl11b is essential for group 2 innate lymphoid cell development.

The Journal of experimental medicine

Walker JA,Oliphant CJ,Englezakis A,Yu Y,Clare S,Rodewald HR,Belz G,Liu P,Fallon PG,McKenzie AN

14-0041 was used in Flow cytometry/Cell sorting to study the role of Bcl11b in the differentiation of group 2 innate lymphoid cells.

Mon Jun 01 00:00:00 EDT 2015

IKKβ acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis.

The Journal of experimental medicine

Pallangyo CK,Ziegler PK,Greten FR

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Mon Dec 14 00:00:00 EST 2015

Co-potentiation of antigen recognition: A mechanism to boost weak T cell responses and provide immunotherapy in vivo.

Science advances

Hoffmann MM,Molina-Mendiola C,Nelson AD,Parks CA,Reyes EE,Hansen MJ,Rajagopalan G,Pease LR,Schrum AG,Gil D

14-0041 was used in Flow cytometry/Cell sorting to investigate co-potentiation, showing that weak T-cell responses can be boosted to provide immunotherapy in vivo.

Thu Oct 01 00:00:00 EDT 2015

Perinatal antibiotic-induced shifts in gut microbiota have differential effects on inflammatory lung diseases.

The Journal of allergy and clinical immunology

Russell SL,Gold MJ,Reynolds LA,Willing BP,Dimitriu P,Thorson L,Redpath SA,Perona-Wright G,Blanchet MR,Mohn WW,Finlay BB,McNagny KM

14-0041 was used in Immunofluorescence to assess the effect of perinatal exposure to antibiotics on the severity of Saccharopolyspora rectivirgula infection.

Thu Jan 01 00:00:00 EST 2015

Adaptive Immune Regulation of Mammary Postnatal Organogenesis.

Developmental cell

Plaks V,Boldajipour B,Linnemann JR,Nguyen NH,Kersten K,Wolf Y,Casbon AJ,Kong N,van den Bijgaart RJ,Sheppard D,Melton AC,Krummel MF,Werb Z

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Mon Sep 14 00:00:00 EDT 2015

Adaptive Immune Regulation of Mammary Postnatal Organogenesis.

Developmental cell

Plaks V,Boldajipour B,Linnemann JR,Nguyen NH,Kersten K,Wolf Y,Casbon AJ,Kong N,van den Bijgaart RJ,Sheppard D,Melton AC,Krummel MF,Werb Z

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Mon Sep 14 00:00:00 EDT 2015

B cell autophagy mediates TLR7-dependent autoimmunity and inflammation.

Autophagy

Weindel CG,Richey LJ,Bolland S,Mehta AJ,Kearney JF,Huber BT

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Immunohistochemistry

Mon Apr 18 00:00:00 EDT 2016

β-catenin promotes regulatory T-cell responses in tumors by inducing vitamin A metabolism in dendritic cells.

Cancer research

Hong Y,Manoharan I,Suryawanshi A,Majumdar T,Angus-Hill ML,Koni PA,Manicassamy B,Mellor AL,Munn DH,Manicassamy S

14-0041 was used in Flow cytometry/Cell sorting to show that dendritic cells in the tumour microenvironment acquire the ability to metabolise vitamin A to produce retinoic acid, driving immune tolerance.

Sun Feb 15 00:00:00 EST 2015

IFN-γ ameliorates autoimmune encephalomyelitis by limiting myelin lipid peroxidation.

Proceedings of the National Academy of Sciences of the United States of America

Sosa RA,Murphey C,Robinson RR,Forsthuber TG

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Immunofluorescence

Tue Sep 08 00:00:00 EDT 2015

Mitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis.

Cell death and differentiation

Cho J,Seo J,Lim CH,Yang L,Shiratsuchi T,Lee MH,Chowdhury RR,Kasahara H,Kim JS,Oh SP,Lee YJ,Terada N

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Tue Sep 01 00:00:00 EDT 2015

ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells.

PLoS biology

Gallego-Ortega D,Ledger A,Roden DL,Law AM,Magenau A,Kikhtyak Z,Cho C,Allerdice SL,Lee HJ,Valdes-Mora F,Herrmann D,Salomon R,Young AI,Lee BY,Sergio CM,Kaplan W,Piggin C,Conway JR,Rabinovich B,Millar EK,Oakes SR,Chtanova T,Swarbrick A,Naylor MJ,O'Toole S,Green AR,Timpson P,Gee JM,Ellis IO,Clark SJ,Ormandy CJ

14-0041 was used in Flow cytometry/Cell sorting to implicate ELF5 as a defining factor in the acquisition of the key aspects of the lethal phenotype in luminal A breast cancer.

Tue Dec 01 00:00:00 EST 2015

A novel TLR2 agonist from Bordetella pertussis is a potent adjuvant that promotes protective immunity with an acellular pertussis vaccine.

Mucosal immunology

Dunne A,Mielke LA,Allen AC,Sutton CE,Higgs R,Cunningham CC,Higgins SC,Mills KH

14-0041 was used in Flow cytometry/Cell sorting to investigate the identification and characterisation of novel TLR2-activating lipoproteins from B. pertussis.

Fri May 01 00:00:00 EDT 2015

Dual-specificity phosphatase 6 regulates CD4+ T-cell functions and restrains spontaneous colitis in IL-10-deficient mice.

Mucosal immunology

Bertin S,Lozano-Ruiz B,Bachiller V,García-Martínez I,Herdman S,Zapater P,Francés R,Such J,Lee J,Raz E,González-Navajas JM

14-0041 was used in Flow cytometry/Cell sorting to demonstrate that DUSP6 regulates CD4+ T-cell activation and differentiation by inhibiting TCR-dependent ERK1/2 activation.

Fri May 01 00:00:00 EDT 2015

Mice lacking Axl and Mer tyrosine kinase receptors are susceptible to experimental autoimmune orchitis induction.

Immunology and cell biology

Li N,Liu Z,Zhang Y,Chen Q,Liu P,Cheng CY,Lee WM,Chen Y,Han D

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Sun Mar 01 00:00:00 EST 2015

Evasion of innate cytosolic DNA sensing by a gammaherpesvirus facilitates establishment of latent infection.

Journal of immunology (Baltimore, Md. : 1950)

Sun C,Schattgen SA,Pisitkun P,Jorgensen JP,Hilterbrand AT,Wang LJ,West JA,Hansen K,Horan KA,Jakobsen MR,O'Hare P,Adler H,Sun R,Ploegh HL,Damania B,Upton JW,Fitzgerald KA,Paludan SR

14-0041 was used in Flow cytometry/Cell sorting to report that murine gammaherpesvirus 68 induces very limited innate immune responses through DNA-stimulated pathways.

Sun Feb 15 00:00:00 EST 2015

Cellular Dynamics of Memory B Cell Populations: IgM+ and IgG+ Memory B Cells Persist Indefinitely as Quiescent Cells.

Journal of immunology (Baltimore, Md. : 1950)

Jones DD,Wilmore JR,Allman D

14-0041 was used in Flow cytometry/Cell sorting to demonstrate that once established, both IgG-positive and less frequent IgM-positive memory populations are exceptionally stable, with little evidence of attrition or cellular turnover.

Sun Nov 15 00:00:00 EST 2015

B cell Rab7 mediates induction of activation-induced cytidine deaminase expression and class-switching in T-dependent and T-independent antibody responses.

Journal of immunology (Baltimore, Md. : 1950)

Pone EJ,Lam T,Lou Z,Wang R,Chen Y,Liu D,Edinger AL,Xu Z,Casali P

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Wed Apr 01 00:00:00 EDT 2015

Histone deacetylation of memory T lymphocytes by You-Gui-Wan alleviates allergen-induced eosinophilic airway inflammation in asthma.

Chinese medicine

Zhang HP,Fu JJ,Fan T,Zhang WB,Wang ZL,Wang L,Wang G

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Mon Jun 15 00:00:00 EDT 2015

Batf3 deficiency is not critical for the generation of CD8α⁺ dendritic cells.

Immunobiology

Mott KR,Maazi H,Allen SJ,Zandian M,Matundan H,Ghiasi YN,Sharifi BG,Underhill D,Akbari O,Ghiasi H

14-0041 was used in Immunohistochemistry to demonstrate that Batf3-/- mice express CD8α + dendritic cells without any known infection.

Wed Apr 01 00:00:00 EDT 2015

dNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis.

Nature communications

Lim S,Kim WJ,Kim YH,Lee S,Koo JH,Lee JA,Yoon H,Kim DH,Park HJ,Kim HM,Lee HG,Yun Kim J,Lee JU,Hun Shin J,Kyun Kim L,Doh J,Kim H,Lee SK,Bothwell ALM,Suh M,Choi JM

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Tue Sep 15 00:00:00 EDT 2015

dNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis.

Nature communications

Lim S,Kim WJ,Kim YH,Lee S,Koo JH,Lee JA,Yoon H,Kim DH,Park HJ,Kim HM,Lee HG,Yun Kim J,Lee JU,Hun Shin J,Kyun Kim L,Doh J,Kim H,Lee SK,Bothwell ALM,Suh M,Choi JM

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Tue Sep 15 00:00:00 EDT 2015

ENPP1-Fc prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancy.

Nature communications

Albright RA,Stabach P,Cao W,Kavanagh D,Mullen I,Braddock AA,Covo MS,Tehan M,Yang G,Cheng Z,Bouchard K,Yu ZX,Thorn S,Wang X,Folta-Stogniew EJ,Negrete A,Sinusas AJ,Shiloach J,Zubal G,Madri JA,De La Cruz EM,Braddock DT

14-0041 was used in Functional assays to investigate treatment options for generalized arterial calcification of infancy.

Tue Dec 01 00:00:00 EST 2015

Chronic Trichuris muris Infection in C57BL/6 Mice Causes Significant Changes in Host Microbiota and Metabolome: Effects Reversed by Pathogen Clearance.

PloS one

Houlden A,Hayes KS,Bancroft AJ,Worthington JJ,Wang P,Grencis RK,Roberts IS

14-0041 was used in Flow cytometry/Cell sorting to investigate the effects of T. muris infection on the faecal microbiota of mice.

Wed Apr 06 00:00:00 EDT 2016

Small-molecule inhibitors targeting INK4 protein p18(INK4C) enhance ex vivo expansion of haematopoietic stem cells.

Nature communications

Gao Y,Yang P,Shen H,Yu H,Song X,Zhang L,Zhang P,Cheng H,Xie Z,Hao S,Dong F,Ma S,Ji Q,Bartlow P,Ding Y,Wang L,Liu H,Li Y,Cheng H,Miao W,Yuan W,Yuan Y,Cheng T,Xie XQ

14-0041 was used in Flow cytometry/Cell sorting to investigate how putative small-molecule inhibitors for p18 protein are valuable for further dissecting the signalling pathways of stem cell self-renewal.

Wed Feb 18 00:00:00 EST 2015

Mannan-modified adenovirus targeting TERT and VEGFR-2: A universal tumour vaccine.

Scientific reports

Wang Y,Zhang J,Wu Y,Ding ZY,Luo XM,Liu J,Zhong WN,Deng GH,Xia XY,Deng YT,Wei YQ,Jiang Y

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Thu Jun 18 00:00:00 EDT 2015

Distinct in vitro properties of embryonic and extraembryonic fibroblast-like cells are reflected in their in vivo behavior following grafting in the adult mouse brain.

Cell transplantation

Costa R,Bergwerf I,Santermans E,De Vocht N,Praet J,Daans J,Le Blon D,Hoornaert C,Reekmans K,Hens N,Goossens H,Berneman Z,Parolini O,Alviano F,Ponsaerts P

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Mon Nov 16 00:00:00 EST 2015

Mechanisms of immunity in post-exposure vaccination against Ebola virus infection.

PloS one

Bradfute SB,Anthony SM,Stuthman KS,Ayithan N,Tailor P,Shaia CI,Bray M,Ozato K,Bavari S

14-0041 was used in Functional assays to analyse the expression levels of various cytokines in the serum of mice given an Ebola virus-like particle.

Tue Feb 23 00:00:00 EST 2016

Intranasal Administration of Lentiviral miR-135a Regulates Mast Cell and Allergen-Induced Inflammation by Targeting GATA-3.

PloS one

Deng YQ,Yang YQ,Wang SB,Li F,Liu MZ,Hua QQ,Tao ZZ

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Tue May 31 00:00:00 EDT 2016

Interleukin-25 Mediates Transcriptional Control of PD-L1 via STAT3 in Multipotent Human Mesenchymal Stromal Cells (hMSCs) to Suppress Th17 Responses.

Stem cell reports

Wang WB,Yen ML,Liu KJ,Hsu PJ,Lin MH,Chen PM,Sudhir PR,Chen CH,Chen CH,Sytwu HK,Yen BL

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Tue Sep 08 00:00:00 EDT 2015

Overexpression of RhoH Permits to Bypass the Pre-TCR Checkpoint.

PloS one

Tamehiro N,Oda H,Shirai M,Suzuki H

14-0041 was used in Flow cytometry/Cell sorting to indicate that an excess amount of RhoH is able to initiate pre-TCR signalling in the absence of pre-TCR complexes.

Mon Apr 25 00:00:00 EDT 2016

Protection against H5N1 Influenza Virus Induced by Matrix-M Adjuvanted Seasonal Virosomal Vaccine in Mice Requires Both Antibodies and T Cells.

PloS one

Cox F,Baart M,Huizingh J,Tolboom J,Dekking L,Goudsmit J,Saeland E,Radošević K

14-0041 was used in Functional assays to investigate the contribution of humoral and cellular immune responses to heterosubtypic protection against H5N1 induced by a Matrix-M adjuvanted seasonal influenza vaccine.

Fri Jun 24 00:00:00 EDT 2016

Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction.

Nature communications

Rouhani SJ,Eccles JD,Riccardi P,Peske JD,Tewalt EF,Cohen JN,Liblau R,Mäkinen T,Engelhard VH

14-0041 was used in Flow cytometry/Cell sorting to demonstrate that when β-galactosidase (β-gal) is expressed in LECs, β-gal-specific CD8 T cells undergo deletion via the PD-1/PD-L1 and LAG-3/MHC-II pathways.

Fri Apr 10 00:00:00 EDT 2015

Disease severity and mortality can be independently regulated in a mouse model of experimental graft versus host disease.

PloS one

Galvani RG,Lemos R,Areal RB,Salvador PA,Zamboni DS,Wanderley JL,Bonomo A

14-0041 was used in Flow cytometry/Cell sorting to investigate the exact cause of death in graft versus host disease, showing that disease severity and mortality can be independently regulated.

Mon Oct 19 00:00:00 EDT 2015

A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia.

Nature medicine

Herranz D,Ambesi-Impiombato A,Palomero T,Schnell SA,Belver L,Wendorff AA,Xu L,Castillo-Martin M,Llobet-Navás D,Cordon-Cardo C,Clappier E,Soulier J,Ferrando AA

14-0041 was used in Flow cytometry/Cell sorting to identify N-Me as a long-range oncogenic enhancer implicated directly in the pathogenesis of human leukaemia.

Wed Oct 01 00:00:00 EDT 2014

The E3 ubiquitin ligase Itch is required for the differentiation of follicular helper T cells.

Nature immunology

Xiao N,Eto D,Elly C,Peng G,Crotty S,Liu YC

14-0041 was used in Flow cytometry/Cell sorting to investigate the molecular mechanisms that regulate the induction of T(FH) cells, showing that Itch is required.

Tue Jul 01 00:00:00 EDT 2014

In utero depletion of fetal hematopoietic stem cells improves engraftment after neonatal transplantation in mice.

Blood

Derderian SC,Togarrati PP,King C,Moradi PW,Reynaud D,Czechowicz A,Weissman IL,MacKenzie TC

14-0041 was used in Flow cytometry/Cell sorting to develop a successful foetal conditioning strategy associated with minimal toxicity.

Thu Aug 07 00:00:00 EDT 2014

Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm.

The Journal of clinical investigation

Kong G,Wunderlich M,Yang D,Ranheim EA,Young KH,Wang J,Chang YI,Du J,Liu Y,Tey SR,Zhang X,Juckett M,Mattison R,Damnernsawad A,Zhang J,Mulloy JC,Zhang J

14-0041 was used in Flow cytometry/Cell sorting to investigate the effect of combined targeting of MEK/ERK and JAK/STAT signalling on the murine myeloproliferative neoplasm.

Sun Jun 01 00:00:00 EDT 2014

Intrinsic TGF-β signaling promotes age-dependent CD8+ T cell polyfunctionality attrition.

The Journal of clinical investigation

Bhadra R,Moretto MM,Castillo JC,Petrovas C,Ferrando-Martinez S,Shokal U,Leal M,Koup RA,Eleftherianos I,Khan IA

14-0041 was used in Flow cytometry/Cell sorting to investigate the progressive loss of CD8+ T cell polyfunctionality during aging, using animals challenged with the obligate intracellular pathogen Encephalitozoon cuniculi.

Sun Jun 01 00:00:00 EDT 2014

Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis.

EMBO molecular medicine

Basler M,Mundt S,Muchamuel T,Moll C,Jiang J,Groettrup M,Kirk CJ

14-0041 was used in Flow cytometry/Cell sorting to investigate the therapeutic efficacy of an immunoproteasome inhibitor, ONX 0914, in two different mouse models of multiple sclerosis.

Sat Feb 01 00:00:00 EST 2014

Autophagy regulates the therapeutic potential of mesenchymal stem cells in experimental autoimmune encephalomyelitis.

Autophagy

Dang S,Xu H,Xu C,Cai W,Li Q,Cheng Y,Jin M,Wang RX,Peng Y,Zhang Y,Wu C,He X,Wan B,Zhang Y

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Tue Jul 01 00:00:00 EDT 2014

Diacylglycerol kinase α establishes T cell polarity by shaping diacylglycerol accumulation at the immunological synapse.

Science signaling

Chauveau A,Le Floc'h A,Bantilan NS,Koretzky GA,Huse M

14-0041 was used in Immunofluorescence to reveal a previously unappreciated function of DGK-α and provide insight into the mechanisms that determine lymphocyte polarity.

Tue Aug 26 00:00:00 EDT 2014

Requirement for interactions of natural killer T cells and myeloid-derived suppressor cells for transplantation tolerance.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Hongo D,Tang X,Baker J,Engleman EG,Strober S

14-0041 was used in Flow cytometry/Cell sorting to investigate the cellular and molecular mechanisms required for suitable immune tolerance for combined bone marrow and heart transplant acceptance in mice.

Sat Nov 01 00:00:00 EDT 2014

Dietary supplementation with high doses of regular vitamin D3 safely reduces diabetes incidence in NOD mice when given early and long term.

Diabetes

Takiishi T,Ding L,Baeke F,Spagnuolo I,Sebastiani G,Laureys J,Verstuyf A,Carmeliet G,Dotta F,Van Belle TL,Gysemans CA,Mathieu C

14-0041 was used in Flow cytometry/Cell sorting to investigate the effect of vitamin D3 administration during different periods of life on diabetes prevention in NOD mice.

Sun Jun 01 00:00:00 EDT 2014

Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection.

PLoS pathogens

Ataide MA,Andrade WA,Zamboni DS,Wang D,Souza Mdo C,Franklin BS,Elian S,Martins FS,Pereira D,Reed G,Fitzgerald KA,Golenbock DT,Gazzinelli RT

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Wed Jan 01 00:00:00 EST 2014

Few Foxp3⁺ regulatory T cells are sufficient to protect adult mice from lethal autoimmunity.

European journal of immunology

Mayer CT,Ghorbani P,Kühl AA,Stüve P,Hegemann M,Berod L,Gershwin ME,Sparwasser T

14-0041 was used in Flow cytometry/Cell sorting to study the mechanisms underlying why regulatory T cell-depletion fails to cause autoimmunity in adult Depletion of REGulatory T cells mice.

Wed Oct 01 00:00:00 EDT 2014

Internalization and TLR-dependent type I interferon production by monocytes in response to Toxoplasma gondii.

Immunology and cell biology

Han SJ,Melichar HJ,Coombes JL,Chan SW,Koshy AA,Boothroyd JC,Barton GM,Robey EA

14-0041 was used in Flow cytometry/Cell sorting to show that inflammatory monocytes, but not neutrophils, produce IFN-β in response to T. gondii infection.

Sat Nov 01 00:00:00 EDT 2014

IRF4 in dendritic cells inhibits IL-12 production and controls Th1 immune responses against Leishmania major.

Journal of immunology (Baltimore, Md. : 1950)

Akbari M,Honma K,Kimura D,Miyakoda M,Kimura K,Matsuyama T,Yui K

14-0041 was used in Flow cytometry/Cell sorting to investigate the roles of the transcription factor IRF4 in dendritic cells and macrophages in vivo.

Sat Mar 01 00:00:00 EST 2014

Innate immune cell CD45 regulates lymphopenia-induced T cell proliferation.

Journal of immunology (Baltimore, Md. : 1950)

Saunders AE,Shim YA,Johnson P

14-0041 was used in Flow cytometry/Cell sorting to demonstrate a novel role for CD45 on innate immune cells in promoting lymphopenia-induced T cell proliferation.

Mon Sep 15 00:00:00 EDT 2014

Regulation of cyp26a1 on Th17 cells in mouse peri-implantation.

Journal of cellular and molecular medicine

Liu HY,Chao H,Liu ZK,Xia HF,Song Z,Yang Y,Peng JP

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Sat Mar 01 00:00:00 EST 2014

Nizatidine, a small molecular compound, enhances killed H5N1 vaccine cell-mediated responses and protects mice from lethal viral challenge.

Human vaccines & immunotherapeutics

Wang S,Wu B,Xue J,Wang M,Chen R,Wang B

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Mon Jan 05 00:00:00 EST 2015

High-dose interferon-γ promotes abortion in mice by suppressing Treg and Th17 polarization.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

Liu HY,Liu ZK,Chao H,Li Z,Song Z,Yang Y,Peng JP

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Thu May 01 00:00:00 EDT 2014

Somatostatin inhibits the production of interferon-γ by intestinal epithelial cells during intestinal ischemia-reperfusion in macaques.

Digestive diseases and sciences

Liu L,Tan Q,Hu B,Wu H,Wang C,Tang C

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Immunohistochemistry

Wed Oct 01 00:00:00 EDT 2014

Cellular immunotherapy using irradiated lung cancer cell vaccine co-expressing GM-CSF and IL-18 can induce significant antitumor effects.

BMC cancer

Tian H,Shi G,Yang G,Zhang J,Li Y,Du T,Wang J,Xu F,Cheng L,Zhang X,Dai L,Chen X,Zhang S,Yang Y,Yu D,Wei Y,Deng H

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Wed Jan 29 00:00:00 EST 2014

Cellular immunotherapy using irradiated lung cancer cell vaccine co-expressing GM-CSF and IL-18 can induce significant antitumor effects.

BMC cancer

Tian H,Shi G,Yang G,Zhang J,Li Y,Du T,Wang J,Xu F,Cheng L,Zhang X,Dai L,Chen X,Zhang S,Yang Y,Yu D,Wei Y,Deng H

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Wed Jan 29 00:00:00 EST 2014

A chitin-like component on sclerotic cells of Fonsecaea pedrosoi inhibits Dectin-1-mediated murine Th17 development by masking β-glucans.

PloS one

Dong B,Li D,Li R,Chen SC,Liu W,Liu W,Chen L,Chen Y,Zhang X,Tong Z,Xia Y,Xia P,Wang Y,Duan Y

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Mon Sep 28 00:00:00 EDT 2015

Toll-like receptor 9 agonist enhances anti-tumor immunity and inhibits tumor-associated immunosuppressive cells numbers in a mouse cervical cancer model following recombinant lipoprotein therapy.

Molecular cancer

Chang LS,Leng CH,Yeh YC,Wu CC,Chen HW,Huang HM,Liu SJ

14-0041 was used in Functional assays to assess the anti-tumour efficacy of a combination therapy of TLR9 agonist and rlipo-E7m.

Wed Mar 19 00:00:00 EDT 2014

The spleen responds to intestinal manipulation but does not participate in the inflammatory response in a mouse model of postoperative ileus.

PloS one

Costes LM,van der Vliet J,Farro G,Matteoli G,van Bree SH,Olivier BJ,Nolte MA,Boeckxstaens GE,Cailotto C

14-0041 was used in Flow cytometry/Cell sorting to demonstrate that intestinal manipulation results in two distinct phenomena: local intestinal inflammation and a decrease in splenic cellularity.

Fri Nov 06 00:00:00 EST 2015

Epigenetic plasticity of Cd8a locus during CD8(+) T-cell development and effector differentiation and reprogramming.

Nature communications

Harland KL,Day EB,Apte SH,Russ BE,Doherty PC,Turner SJ,Kelso A

14-0041 was used in Flow cytometry/Cell sorting to study whether epigenetic modifications affecting T-cells persist following adoptive transfer of the cells.

Fri Mar 28 00:00:00 EDT 2014

Nfatc2 and Tob1 have non-overlapping function in T cell negative regulation and tumorigenesis.

PloS one

May SL,Zhou Q,Lewellen M,Carter CM,Coffey D,Highfill SL,Bucher CM,Matise I,Morse HC,O'Sullivan MG,Schutten M,Johnson C,Bellgrau D,Blazar BR,Modiano JF

14-0041 was used in Flow cytometry/Cell sorting to study how Nfatc2 and Tob1 are non-redundant regulators of lymphocyte homeostasis.

Mon Oct 19 00:00:00 EDT 2015

CD8α dendritic cells drive establishment of HSV-1 latency.

PloS one

Mott KR,Allen SJ,Zandian M,Konda B,Sharifi BG,Jones C,Wechsler SL,Town T,Ghiasi H

14-0041 was used in Immunohistochemistry to investigate the impact of CD8α dendritic cells on HSV-1 latency in mice.

Tue Jan 20 00:00:00 EST 2015

CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection.

eLife

Linterman MA,Denton AE,Divekar DP,Zvetkova I,Kane L,Ferreira C,Veldhoen M,Clare S,Dougan G,Espéli M,Smith KG

14-0041 was used in Flow cytometry/Cell sorting to determine the role for CD28 after T cell priming.

Mon Oct 27 00:00:00 EDT 2014

Innate signaling promotes formation of regulatory nitric oxide-producing dendritic cells limiting T-cell expansion in experimental autoimmune myocarditis.

Circulation

Kania G,Siegert S,Behnke S,Prados-Rosales R,Casadevall A,Lüscher TF,Luther SA,Kopf M,Eriksson U,Blyszczuk P

14-0041 was used in Flow cytometry/Cell sorting to investigate how activation of innate pattern-recognition receptors is critical not only for disease induction but also for counterregulatory mechanisms, protecting the heart from exaggerated autoimmunity.

Tue Jun 11 00:00:00 EDT 2013

Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells.

Nature immunology

Cohen NR,Brennan PJ,Shay T,Watts GF,Brigl M,Kang J,Brenner MB

14-0041 was used in Flow cytometry/Cell sorting to profile gene expression in invariant natural killer T cells during ontogeny and in peripheral subsets.

Tue Jan 01 00:00:00 EST 2013

CD40L expression permits CD8+ T cells to execute immunologic helper functions.

Blood

Frentsch M,Stark R,Matzmohr N,Meier S,Durlanik S,Schulz AR,Stervbo U,Jürchott K,Gebhardt F,Heine G,Reuter MA,Betts MR,Busch D,Thiel A

14-0041 was used in Flow cytometry/Cell sorting to investigate the role of CD40L in CD8+ T cells, showing that expression permits CD8+ T cells to execute immunologic helper functions.

Thu Jul 18 00:00:00 EDT 2013

Mesenchymal stem cells attenuate ischemic acute kidney injury by inducing regulatory T cells through splenocyte interactions.

Kidney international

Hu J,Zhang L,Wang N,Ding R,Cui S,Zhu F,Xie Y,Sun X,Wu D,Hong Q,Li Q,Shi S,Liu X,Chen X

14-0041 was used in Flow cytometry/Cell sorting to study how mesenchymal stem cells ameliorate ischemic acute kidney injury by inducing regulatory T cells through interactions with splenocytes.

Sun Sep 01 00:00:00 EDT 2013

HDL and Glut1 inhibition reverse a hypermetabolic state in mouse models of myeloproliferative disorders.

The Journal of experimental medicine

Gautier EL,Westerterp M,Bhagwat N,Cremers S,Shih A,Abdel-Wahab O,Lütjohann D,Randolph GJ,Levine RL,Tall AR,Yvan-Charvet L

14-0041 was used in Flow cytometry/Cell sorting to investigate the underlying mechanisms leading to high metabolic rate in myeloproliferative disorders, showing that HDL and Glut1 inhibition reverse hypermetabolic state.

Mon Feb 11 00:00:00 EST 2013

Interleukin-6-signal transducer and activator of transcription-3 signaling mediates aortic dissections induced by angiotensin II via the T-helper lymphocyte 17-interleukin 17 axis in C57BL/6 mice.

Arteriosclerosis, thrombosis, and vascular biology

Ju X,Ijaz T,Sun H,Ray S,Lejeune W,Lee C,Recinos A,Guo DC,Milewicz DM,Tilton RG,Brasier AR

14-0041 was used in Flow cytometry/Cell sorting to suggest that the Th17-IL-17 axis is an important effector arm of Ang II-mediated vascular inflammation.

Mon Jul 01 00:00:00 EDT 2013

Loss of the TGFβ-activating integrin αvβ8 on dendritic cells protects mice from chronic intestinal parasitic infection via control of type 2 immunity.

PLoS pathogens

Worthington JJ,Klementowicz JE,Rahman S,Czajkowska BI,Smedley C,Waldmann H,Sparwasser T,Grencis RK,Travis MA

14-0041 was used in Flow cytometry/Cell sorting to describe a novel cellular and molecular pathway involved in the development of chronic intestinal parasite infection.

Mon May 26 00:00:00 EDT 2014

IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection.

PLoS pathogens

Schmitz I,Schneider C,Fröhlich A,Frebel H,Christ D,Leonard WJ,Sparwasser T,Oxenius A,Freigang S,Kopf M

14-0041 was used in Flow cytometry/Cell sorting to investigate the role of Foxp3+ regulatory T (Treg) cells during viral infections, showing that IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection.

Mon Dec 09 00:00:00 EST 2013

Cbx4 regulates the proliferation of thymic epithelial cells and thymus function.

Development (Cambridge, England)

Liu B,Liu YF,Du YR,Mardaryev AN,Yang W,Chen H,Xu ZM,Xu CQ,Zhang XR,Botchkarev VA,Zhang Y,Xu GL

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Fri Feb 01 00:00:00 EST 2013

A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL).

Disease models & mechanisms

Carofino BL,Ayanga B,Justice MJ

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Fri Nov 01 00:00:00 EDT 2013

Interferon gamma causes olfactory dysfunction without concomitant neuroepithelial damage.

International forum of allergy & rhinology

Pozharskaya T,Lane AP

14-0041 was used in Immunohistochemistry to investigate the direct effect of IFN-γ on olfactory neuron function that may underlie olfactory loss in CRSsNP or viral infections.

Fri Nov 01 00:00:00 EDT 2013

Intrinsic molecular factors cause aberrant expansion of the splenic marginal zone B cell population in nonobese diabetic mice.

Journal of immunology (Baltimore, Md. : 1950)

Stolp J,Mariño E,Batten M,Sierro F,Cox SL,Grey ST,Silveira PA

14-0041 was used in Flow cytometry/Cell sorting to investigate the underlying causes of augmented marginal zone B cell production in NOD mice.

Mon Jul 01 00:00:00 EDT 2013

The influence of T cell Ig mucin-3 signaling on central nervous system autoimmune disease is determined by the effector function of the pathogenic T cells.

Journal of immunology (Baltimore, Md. : 1950)

Lee SY,Goverman JM

14-0041 was used in Flow cytometry/Cell sorting to analyse the role of Tim-3 signalling within various innate immune cells on the development of experimental autoimmune encephalomyelitis.

Wed May 15 00:00:00 EDT 2013

Interleukin-22 as a molecular adjuvant facilitates IL-17-producing CD8+ T cell responses against a HBV DNA vaccine in mice.

Human vaccines & immunotherapeutics

Wu B,Zou Q,Hu Y,Wang B

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Tue Oct 01 00:00:00 EDT 2013

Interleukin-6 expands homeostatic space for peripheral T cells.

Cytokine

Hong C,Nam AS,Keller HR,Ligons DL,Park JY,Yoon HW,Park JJ,Luckey MA,Park JH

14-0041 was used in Flow cytometry/Cell sorting to investigate whether IL-6 promotes T cell survival and homeostasis in vivo, showing that it expands homeostatic space for peripheral T cells.

Fri Nov 01 00:00:00 EDT 2013

The early activation marker CD69 regulates the expression of chemokines and CD4 T cell accumulation in intestine.

PloS one

Radulovic K,Rossini V,Manta C,Holzmann K,Kestler HA,Niess JH

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Immunofluorescence

Thu Jan 23 00:00:00 EST 2014

The early activation marker CD69 regulates the expression of chemokines and CD4 T cell accumulation in intestine.

PloS one

Radulovic K,Rossini V,Manta C,Holzmann K,Kestler HA,Niess JH

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Immunofluorescence

Thu Jan 23 00:00:00 EST 2014

Enhanced immune response against HIV-1 induced by a heterologous DNA prime-adenovirus boost vaccination using mannosylated polyethyleneimine as DNA vaccine adjuvant.

International journal of nanomedicine

Li M,Jiang Y,Xu C,Zhang Z,Sun X

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Wed Apr 02 00:00:00 EDT 2014

T-Bet and Eomes Regulate the Balance between the Effector/Central Memory T Cells versus Memory Stem Like T Cells.

PloS one

Li G,Yang Q,Zhu Y,Wang HR,Chen X,Zhang X,Lu B

14-0041 was used in Flow cytometry/Cell sorting to investigate the role of T-bet and Eomes in shaping the memory T cell pool.

Tue Oct 10 00:00:00 EDT 2017

Nod2 activates NF-kB in CD4+ T cells but its expression is dispensable for T cell-induced colitis.

PloS one

Zanello G,Goethel A,Forster K,Geddes K,Philpott DJ,Croitoru K

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Thu Jul 31 00:00:00 EDT 2014

Differential influences of the aryl hydrocarbon receptor on Th17 mediated responses in vitro and in vivo.

PloS one

Duarte JH,Di Meglio P,Hirota K,Ahlfors H,Stockinger B

14-0041 was used in Flow cytometry/Cell sorting to study how the immuno-modulatory effect of TCDD administration for EAE is not the consequence of de novo Treg generation, but the inhibition of Th17 cell differentiation.

Tue Aug 12 00:00:00 EDT 2014

Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice.

Nature

Devkota S,Wang Y,Musch MW,Leone V,Fehlner-Peach H,Nadimpalli A,Antonopoulos DA,Jabri B,Chang EB

14-0041 was used in Flow cytometry/Cell sorting to show that different dietary fat change the conditions for microbial assemblage in the digestive system in a T helper 1 cell dependent manner.

Thu Jul 05 00:00:00 EDT 2012

The receptor Ly108 functions as a SAP adaptor-dependent on-off switch for T cell help to B cells and NKT cell development.

Immunity

Kageyama R,Cannons JL,Zhao F,Yusuf I,Lao C,Locci M,Schwartzberg PL,Crotty S

14-0041 was used in Flow cytometry/Cell sorting to investigate the mechanisms underlying the defects in humoural immunity present in humans and mice deficient in the adaptor protein, SAP.

Fri Jun 29 00:00:00 EDT 2012

Prostaglandin E2 suppresses antifungal immunity by inhibiting interferon regulatory factor 4 function and interleukin-17 expression in T cells.

Immunity

Valdez PA,Vithayathil PJ,Janelsins BM,Shaffer AL,Williamson PR,Datta SK

14-0041 was used in Flow cytometry/Cell sorting to study the effect of prostaglandin E2 on the function of Th17 cells during differentiation.

Fri Apr 20 00:00:00 EDT 2012

Molecular definition of the identity and activation of natural killer cells.

Nature immunology

Bezman NA,Kim CC,Sun JC,Min-Oo G,Hendricks DW,Kamimura Y,Best JA,Goldrath AW,Lanier LL

14-0041 was used in Flow cytometry/Cell sorting to systematically define the transcriptome of mouse natural killer cells in several contexts.

Mon Oct 01 00:00:00 EDT 2012

Tryptophan hydroxylase-1 regulates immune tolerance and inflammation.

The Journal of experimental medicine

Nowak EC,de Vries VC,Wasiuk A,Ahonen C,Bennett KA,Le Mercier I,Ha DG,Noelle RJ

14-0041 was used in Flow cytometry/Cell sorting to investigate the role of Tph-1 in regulation of immunity.

Mon Oct 22 00:00:00 EDT 2012

An in vivo immunotherapy screen of costimulatory molecules identifies Fc-OX40L as a potent reagent for the treatment of established murine gliomas.

Clinical cancer research : an official journal of the American Association for Cancer Research

Murphy KA,Lechner MG,Popescu FE,Bedi J,Decker SA,Hu P,Erickson JR,O'Sullivan MG,Swier L,Salazar AM,Olin MR,Epstein AL,Ohlfest JR

14-0041 was used in Flow cytometry/Cell sorting to investigate the combination of a tumor lysate vaccine with a panel of costimulatory molecules for treatment of gliomas.

Sat Sep 01 00:00:00 EDT 2012

Immune response is an important aspect of the antitumor effect produced by a CD40L-encoding oncolytic adenovirus.

Cancer research

Diaconu I,Cerullo V,Hirvinen ML,Escutenaire S,Ugolini M,Pesonen SK,Bramante S,Parviainen S,Kanerva A,Loskog AS,Eliopoulos AG,Pesonen S,Hemminki A

14-0041 was used in Immunohistochemistry to test whether a transcriptionally targeted oncolytic adenovirus, which features a capsid modification and is armed with CD40L, can result in oncolytic antitumor activity and stimulate an immune response.

Tue May 01 00:00:00 EDT 2012

PIDDosome-independent tumor suppression by Caspase-2.

Cell death and differentiation

Manzl C,Peintner L,Krumschnabel G,Bock F,Labi V,Drach M,Newbold A,Johnstone R,Villunger A

14-0041 was used in Flow cytometry/Cell sorting to investigate the role of PIDD, RIP-1 kinase and Nemo/IKKγ in oncogenesis induced by DNA damage or oncogenic stress in gene-ablated mice.

Mon Oct 01 00:00:00 EDT 2012

Immunity to sand fly salivary protein LJM11 modulates host response to vector-transmitted leishmania conferring ulcer-free protection.

The Journal of investigative dermatology

Gomes R,Oliveira F,Teixeira C,Meneses C,Gilmore DC,Elnaiem DE,Kamhawi S,Valenzuela JG

14-0041 was used in Flow cytometry/Cell sorting to investigate LJM11 as an immunomodulator that drives an efficient and controlled protective immune response to a sand fly-transmitted Leishmania.

Sat Dec 01 00:00:00 EST 2012

FOXO3 regulates CD8 T cell memory by T cell-intrinsic mechanisms.

PLoS pathogens

Sullivan JA,Kim EH,Plisch EH,Peng SL,Suresh M

14-0041-82 was used in Immunodepletion to elucidate the potentially dynamic role for FOXO3 in regulating homeostasis of activated CD8 T cells in lymphoid and non-lymphoid organs.

Wed Feb 01 00:00:00 EST 2012

The American journal of pathology

Kojima T,Wakamatsu TH,Dogru M,Ogawa Y,Igarashi A,Ibrahim OM,Inaba T,Shimizu T,Noda S,Obata H,Nakamura S,Wakamatsu A,Shirasawa T,Shimazaki J,Negishi K,Tsubota K

14-0041 was used in Immunofluorescence to investigate how Sod1(-/-) mice may be a good model system in which to study the mechanism of reactive oxygen species-mediated lacrimal gland alterations.

Tue May 01 00:00:00 EDT 2012

NK cells are required for costimulatory blockade induced tolerance to vascularized allografts.

Transplantation

van der Touw W,Burrell B,Lal G,Bromberg JS

14-0041 was used in Immunohistochemistry on frozen tissues to investigate the role of NK cells in allograft tolerance, showing that they are required for costimulatory blockade induced tolerance to vascularised allografts.

Thu Sep 27 00:00:00 EDT 2012

Role of Francisella lipid A phosphate modification in virulence and long-term protective immune responses.

Infection and immunity

Kanistanon D,Powell DA,Hajjar AM,Pelletier MR,Cohen IE,Way SS,Skerrett SJ,Wang X,Raetz CR,Ernst RK

14-0041 was used in Flow cytometry/Cell sorting to study the pathogenic effects of LPS modifications at the lipid A component of a Francisella novicida mutant.

Thu Mar 01 00:00:00 EST 2012

Depletion of neutrophils in a protective model of pulmonary cryptococcosis results in increased IL-17A production by γδ T cells.

BMC immunology

Wozniak KL,Kolls JK,Wormley FL

14-0041 was used in Immunodepletion to study the role of γδ+ T cells in mediating IL-17A production in neutropenic mice during the protective response to Cryptococcus neoformans infection.

Fri Dec 07 00:00:00 EST 2012

Recombinant lipidated HPV E7 induces a Th-1-biased immune response and protective immunity against cervical cancer in a mouse model.

PloS one

Huang CY,Chen JJ,Shen KY,Chang LS,Yeh YC,Chen IH,Chong P,Liu SJ,Leng CH

14-0041 was used in Functional assays to demonstrate that rlipo-E7m could be a promising candidate for treating HPV-associated tumors.

Wed Jan 16 00:00:00 EST 2013

CD69 does not affect the extent of T cell priming.

PloS one

Alari-Pahissa E,Notario L,Lorente E,Vega-Ramos J,Justel A,López D,Villadangos JA,Lauzurica P

14-0041 was used in Flow cytometry/Cell sorting to investigate the role of CD69 in T cell activation, showing that CD69 does not affect the extent of T cell priming.

Mon May 06 00:00:00 EDT 2013

Soluble MOG35-55/I-A(b) dimers ameliorate experimental autoimmune encephalomyelitis by reducing encephalitogenic T cells.

PloS one

Gong Y,Wang Z,Liang Z,Duan H,Ouyang L,Yu Q,Xu Z,Shen G,Weng X,Wu X

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Fri Jul 19 00:00:00 EDT 2013

CD4 T-cell-independent antibody response reduces enterovirus 71 lethality in mice by decreasing tissue viral loads.

Clinical & developmental immunology

Wang LC,Kao CM,Ling P,Su IJ,Chang TM,Chen SH

14-0041 was used in Flow cytometry/Cell sorting to show that the CD4 T-cell-independent antibody response promotes the survival of EV71-infected mice.

Thu May 16 00:00:00 EDT 2013

Virus-induced tumor inflammation facilitates effective DC cancer immunotherapy in a Treg-dependent manner in mice.

The Journal of clinical investigation

Woller N,Knocke S,Mundt B,Gürlevik E,Strüver N,Kloos A,Boozari B,Schache P,Manns MP,Malek NP,Sparwasser T,Zender L,Wirth TC,Kubicka S,Kühnel F

14-0041 was used in Functional assays to highlight viruses as attractive tools for eliciting effective antitumour responses upon DC vaccination.

Fri Jul 01 00:00:00 EDT 2011

VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses.

The Journal of experimental medicine

Wang L,Rubinstein R,Lines JL,Wasiuk A,Ahonen C,Guo Y,Lu LF,Gondek D,Wang Y,Fava RA,Fiser A,Almo S,Noelle RJ

14-0041 was used in Functional assays to show that VISTA has functional activities that are nonredundant with other Ig superfamily members and may play a role in the development of autoimmunity.

Mon Mar 14 00:00:00 EDT 2011

Maximal T cell-mediated antitumor responses rely upon CCR5 expression in both CD4(+) and CD8(+) T cells.

Cancer research

González-Martín A,Gómez L,Lustgarten J,Mira E,Mañes S

14-0041 was used in Immunofluorescence to investigate the relevance of the chemokine receptor CCR5 in tumoural immune control.

Mon Aug 15 00:00:00 EDT 2011

T cell-mediated protection against lethal 2009 pandemic H1N1 influenza virus infection in a mouse model.

Journal of virology

Guo H,Santiago F,Lambert K,Takimoto T,Topham DJ

14-0041 was used in Functional assays to explore the protection mechanisms of cross-reactive T-cell responses against H1N1 in vivo.

Sat Jan 01 00:00:00 EST 2011

Rapamycin ameliorates dystrophic phenotype in mdx mouse skeletal muscle.

Molecular medicine (Cambridge, Mass.)

Eghtesad S,Jhunjhunwala S,Little SR,Clemens PR

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Immunohistochemistry

Sun Mar 25 00:00:00 EDT 2012

T cell factor 1 regulates thymocyte survival via a RORγt-dependent pathway.

Journal of immunology (Baltimore, Md. : 1950)

Wang R,Xie H,Huang Z,Ma J,Fang X,Ding Y,Sun Z

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Thu Dec 01 00:00:00 EST 2011

Identification of semaphorin 4B as a negative regulator of basophil-mediated immune responses.

Journal of immunology (Baltimore, Md. : 1950)

Nakagawa Y,Takamatsu H,Okuno T,Kang S,Nojima S,Kimura T,Kataoka TR,Ikawa M,Toyofuku T,Katayama I,Kumanogoh A

14-0041 was used in Flow cytometry/Cell sorting to screen semaphorins for immune involvement, identifying Sema4B as a suppressor of basophil-mediated Th2-skewing.

Tue Mar 01 00:00:00 EST 2011

T cell-intrinsic factors contribute to the differential ability of CD8+ T cells to rapidly secrete IFN-γ in the absence of antigen.

Journal of immunology (Baltimore, Md. : 1950)

Bou Ghanem EN,Nelson CC,D'Orazio SE

14-0041 was used in Flow cytometry/Cell sorting to demonstrate that the microenvironment in L. monocytogenes-infected BALB/c mice is sufficient to induce responsive CD8(+) T cells to rapidly secrete IFN-γ.

Tue Feb 01 00:00:00 EST 2011

Protective immunity against experimental pulmonary cryptococcosis in T cell-depleted mice.

Clinical and vaccine immunology : CVI

Wozniak KL,Young ML,Wormley FL

14-0041 was used in Functional assays to determine whether protection against experimental pulmonary cryptococcosis can be generated in T cell-deficient hosts.

Sun May 01 00:00:00 EDT 2011

Localized delivery of interferon-β by Lactobacillus exacerbates experimental colitis.

PloS one

McFarland AP,Savan R,Wagage S,Addison A,Ramakrishnan K,Karwan M,Duong T,Young HA

14-0041 was used in Flow cytometry/Cell sorting to identify a correlation between the loss/down-regulation of IFNAR1 on DCs and exacerbation of colitis.

Fri Feb 18 00:00:00 EST 2011

Expression of miRNAs miR-133b and miR-206 in the Il17a/f locus is co-regulated with IL-17 production in αβ and γδ T cells.

PloS one

Haas JD,Nistala K,Petermann F,Saran N,Chennupati V,Schmitz S,Korn T,Wedderburn LR,Förster R,Krueger A,Prinz I

14-0041 was used in Flow cytometry/Cell sorting to investigate epigenetic modifications of the Il17a/f locus, showing that expression of miRNAs miR-133b and miR-206 is co-regulated with IL-17 production in αβ and γδ T cells.

Thu Sep 29 00:00:00 EDT 2011

Suppression of B-cell lymphomagenesis by the BH3-only proteins Bmf and Bad.

Blood

Frenzel A,Labi V,Chmelewskij W,Ploner C,Geley S,Fiegl H,Tzankov A,Villunger A

14-0041 was used in Flow cytometry/Cell sorting to demonstrate the potential of BH3-only proapoptotic Bcl-2 family members to regulate excessive lymphocyte proliferation.

Thu Feb 04 00:00:00 EST 2010

Angiotensin II sustains brain inflammation in mice via TGF-beta.

The Journal of clinical investigation

Lanz TV,Ding Z,Ho PP,Luo J,Agrawal AN,Srinagesh H,Axtell R,Zhang H,Platten M,Wyss-Coray T,Steinman L

14-0041 was used in Flow cytometry/Cell sorting to identify angiotensin II as a paracrine mediator, sustaining inflammation in the CNS via TGF-β.

Sun Aug 01 00:00:00 EDT 2010

In situ vaccination combined with androgen ablation and regulatory T-cell depletion reduces castration-resistant tumor burden in prostate-specific pten knockout mice.

Cancer research

Akins EJ,Moore ML,Tang S,Willingham MC,Tooze JA,Dubey P

14-0041 was used in Immunofluorescence on frozen tissues to assess the acute and chronic effect of androgen ablation on the localisation of T-cell subsets within castration-resistant murine prostate cancer.

Sat May 01 00:00:00 EDT 2010

Adenosine A2A receptor activation on CD4+ T lymphocytes and neutrophils attenuates lung ischemia-reperfusion injury.

The Journal of thoracic and cardiovascular surgery

Sharma AK,Laubach VE,Ramos SI,Zhao Y,Stukenborg G,Linden J,Kron IL,Yang Z

14-0041 was used in Immunohistochemistry to investigate how CD4+ T cells play a key role in mediating lung inflammation after ischemia-reperfusion.

Mon Feb 01 00:00:00 EST 2010

Store-operated Ca2+ entry through ORAI1 is critical for T cell-mediated autoimmunity and allograft rejection.

Journal of immunology (Baltimore, Md. : 1950)

McCarl CA,Khalil S,Ma J,Oh-hora M,Yamashita M,Roether J,Kawasaki T,Jairaman A,Sasaki Y,Prakriya M,Feske S

14-0041 was used in Flow cytometry/Cell sorting to reaffirm the critical role of ORAI1 for T cell function, and provide important insights into the in vivo functions of CRAC channels for T cell-mediated immunity.

Mon Nov 15 00:00:00 EST 2010

T-bet and eomesodermin are required for T cell-mediated antitumor immune responses.

Journal of immunology (Baltimore, Md. : 1950)

Zhu Y,Ju S,Chen E,Dai S,Li C,Morel P,Liu L,Zhang X,Lu B

14-0041 was used in Flow cytometry/Cell sorting to define T-bet and Eomes as critical regulators of T cell-mediated immune responses against tumours.

Wed Sep 15 00:00:00 EDT 2010

Effects of irradiating adult mdx mice before full-length dystrophin cDNA transfer on host anti-dystrophin immunity.

Gene therapy

Eghtesad S,Zheng H,Nakai H,Epperly MW,Clemens PR

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Immunohistochemistry

Wed Sep 01 00:00:00 EDT 2010

Cryptococcus neoformans variants generated by phenotypic switching differ in virulence through effects on macrophage activation.

Infection and immunity

Guerrero A,Jain N,Wang X,Fries BC

14-0041 was used in Flow cytometry/Cell sorting to investigate the interaction between macrophages and cells from smooth-colony or mucoid-colony variants arising from phenotypic switching of Cryptococcus neoformans.

Mon Mar 01 00:00:00 EST 2010

The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation.

Nature immunology

Koch MA,Tucker-Heard G,Perdue NR,Killebrew JR,Urdahl KB,Campbell DJ

14-0041 was used in Flow cytometry/Cell sorting to study how in a subset of CD4(+) T cells, the activities of the transcription factors Foxp3 and T-bet are overlaid.

Mon Jun 01 00:00:00 EDT 2009

Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury.

The Journal of clinical investigation

Heymann F,Meyer-Schwesinger C,Hamilton-Williams EE,Hammerich L,Panzer U,Kaden S,Quaggin SE,Floege J,Gröne HJ,Kurts C

14-0041 was used in Flow cytometry/Cell sorting to investigate the role of several immune cell types within tubulointerstitial mononuclear cell infiltrates in the progression of kidney disease.

Fri May 01 00:00:00 EDT 2009

Inhibition of Th17 cells regulates autoimmune diabetes in NOD mice.

Diabetes

Emamaullee JA,Davis J,Merani S,Toso C,Elliott JF,Thiesen A,Shapiro AM

14-0041 was used in Immunofluorescence to suggest that Th17 cells are involved in the pathogenesis of autoimmune diabetes.

Mon Jun 01 00:00:00 EDT 2009

Critical roles of lysosomal acid lipase in T cell development and function.

The American journal of pathology

Qu P,Du H,Wilkes DS,Yan C

14-0041-82 was used in Flow Cytometry to conclude that the altered development and function of lal(-/-) T cells contributes to disease formation in various organs during LAL deficiency.

Sun Mar 01 00:00:00 EST 2009

Galectin-3 is critical for the development of the allergic inflammatory response in a mouse model of atopic dermatitis.

The American journal of pathology

Saegusa J,Hsu DK,Chen HY,Yu L,Fermin A,Fung MA,Liu FT

14-0041 was used in Immunohistochemistry on frozen tissues to investigate the role of galectin-3 in the development of allergic skin inflammation.

Sun Mar 01 00:00:00 EST 2009

Peripheral dendritic cells are essential for both the innate and adaptive antiviral immune responses in the central nervous system.

Virology

Steel CD,Hahto SM,Ciavarra RP

14-0041-82 was used in Flow Cytometry to study the adaptive primary antiviral immune response in the CNS and the effect of dendritic cells upon this in vivo.

Sat Apr 25 00:00:00 EDT 2009

Gene expression profiling of leukemia stem cells.

Methods in molecular biology (Clifton, N.J.)

Krivtsov AV,Wang Y,Feng Z,Armstrong SA

14-0041 was used in Flow cytometry/Cell sorting to illustrate methods to isolate a leukemia stem cell population, amplify RNA, and perform microarray analyses.

Tue May 19 00:00:00 EDT 2009

Enhanced efficacy and reduced toxicity of multifactorial adjuvants compared with unitary adjuvants as cancer vaccines.

Blood

Ahonen CL,Wasiuk A,Fuse S,Turk MJ,Ernstoff MS,Suriawinata AA,Gorham JD,Kedl RM,Usherwood EJ,Noelle RJ

14-0041 was used in Flow cytometry/Cell sorting to report the therapeutic effects of combinatorial use of CD40 and TLR agonists as a cancer vaccine.

Sat Mar 15 00:00:00 EDT 2008

Dendritic cells and B cells maximize mucosal Th1 memory response to herpes simplex virus.

The Journal of experimental medicine

Iijima N,Linehan MM,Zamora M,Butkus D,Dunn R,Kehry MR,Laufer TM,Iwasaki A

14-0041 was used in Functional assays to investigate the antiviral mechanism of Th1, showing that dendritic cells and B cells maximise mucosal Th1 memory response to herpes simplex virus.

Mon Dec 22 00:00:00 EST 2008

Dendritic cells and B cells maximize mucosal Th1 memory response to herpes simplex virus.

The Journal of experimental medicine

Iijima N,Linehan MM,Zamora M,Butkus D,Dunn R,Kehry MR,Laufer TM,Iwasaki A

14-0041 was used in Functional assays to investigate the antiviral mechanism of Th1, showing that dendritic cells and B cells maximise mucosal Th1 memory response to herpes simplex virus.

Mon Dec 22 00:00:00 EST 2008

Fundamental differences in the dynamics of CNS lesion development and composition in MP4- and MOG peptide 35-55-induced experimental autoimmune encephalomyelitis.

Clinical immunology (Orlando, Fla.)

Kuerten S,Javeri S,Tary-Lehmann M,Lehmann PV,Angelov DN

14-0041 was used in Immunohistochemistry to investigate the histopathological differences between two mouse models of experimental autoimmune encephalomyelitis.

Sat Nov 01 00:00:00 EDT 2008

IL-10 from CD4CD25Foxp3CD127 adaptive regulatory T cells modulates parasite clearance and pathology during malaria infection.

PLoS pathogens

Couper KN,Blount DG,Wilson MS,Hafalla JC,Belkaid Y,Kamanaka M,Flavell RA,de Souza JB,Riley EM

14-0041 was used in Flow cytometry/Cell sorting to investigate the cellular source of IL-10 and TGF-beta during malaria infection, showing that IL-10 from CD4+CD25-Foxp3-CD127- adaptive Tregs modulates parasite clearance and pathology.

Fri Feb 29 00:00:00 EST 2008

Unique receptor repertoire in mouse uterine NK cells.

Journal of immunology (Baltimore, Md. : 1950)

Yadi H,Burke S,Madeja Z,Hemberger M,Moffett A,Colucci F

14-0041-82 was used in Flow Cytometry to define the receptor repertoire and phenotype of uterine NK cells at mid-gestation in mice.

Sat Nov 01 00:00:00 EDT 2008

Suppression of alkali burn-induced corneal neovascularization by dendritic cell vaccination targeting VEGF receptor 2.

Investigative ophthalmology & visual science

Mochimaru H,Usui T,Yaguchi T,Nagahama Y,Hasegawa G,Usui Y,Shimmura S,Tsubota K,Amano S,Kawakami Y,Ishida S

Thu May 01 00:00:00 EDT 2008

Ikaros directly represses the notch target gene Hes1 in a leukemia T cell line: implications for CD4 regulation.

The Journal of biological chemistry

Kathrein KL,Chari S,Winandy S

14-0041 was used in Flow cytometry/Cell sorting to investigate the role of the transcriptional regulator Ikaros in the regulation of the transcriptional repressor of Hes1.

Fri Apr 18 00:00:00 EDT 2008

Neutralization of IL-4 and IFN-γ Facilitates inducing TGF-β-induced CD4(+)Foxp3(+) Regulatory Cells.

International journal of biomedical science : IJBS

Tao X,Ma J,Zhang Y,Yu J,Cai L,Wang J,Zheng SG

14-0041 was used in Magnetic cell separation to determine cytokine factors that can affect the ability of TGF-β to induce Foxp3 expression.

Sat Mar 01 00:00:00 EST 2008

RhoH is important for positive thymocyte selection and T-cell receptor signaling.

Blood

Dorn T,Kuhn U,Bungartz G,Stiller S,Bauer M,Ellwart J,Peters T,Scharffetter-Kochanek K,Semmrich M,Laschinger M,Holzmann B,Klinkert WE,Straten PT,Køllgaard T,Sixt M,Brakebusch C

14-0041 was used in Flow cytometry/Cell sorting to investigate how RhoH is important for pre-TCR and TCR signaling because it allows the efficient interaction of ZAP70 with the LAT signalosome, thus regulating thymocyte development.

Thu Mar 15 00:00:00 EDT 2007

RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla.

The Journal of experimental medicine

Rossi SW,Kim MY,Leibbrandt A,Parnell SM,Jenkinson WE,Glanville SH,McConnell FM,Scott HS,Penninger JM,Jenkinson EJ,Lane PJ,Anderson G

14-0041 was used in Immunofluorescence to demonstrate a novel role for a CD4(+)3(-) inducer cell population, showing that RANK signals regulate development of Aire-expressing epithelial cells in the thymic medulla.

Mon Jun 11 00:00:00 EDT 2007

Myocardial infarct-sparing effect of adenosine A2A receptor activation is due to its action on CD4+ T lymphocytes.

Circulation

Yang Z,Day YJ,Toufektsian MC,Xu Y,Ramos SI,Marshall MA,French BA,Linden J

Tue Nov 07 00:00:00 EST 2006

Novel animal models for Sjögren's syndrome: expression and transfer of salivary gland dysfunction from regulatory T cell-deficient mice.

Journal of autoimmunity

Sharma R,Zheng L,Guo X,Fu SM,Ju ST,Jarjour WN

14-0041 was used in Flow cytometry/Cell sorting to investigate whether salivary and lacrimal glands are targeted in IL-2 knockout, IL-2Ralpha KO and scurfy mice.

Fri Dec 01 00:00:00 EST 2006

Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis.

Proceedings of the National Academy of Sciences of the United States of America

Woolf E,Xiao C,Fainaru O,Lotem J,Rosen D,Negreanu V,Bernstein Y,Goldenberg D,Brenner O,Berke G,Levanon D,Groner Y

Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry

Tue Jun 24 00:00:00 EDT 2003

Bioinformatics

Protein Aliases: CD4; CD4 antigen p55; cd4a; fCD4; Leu-3; T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4; T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4)

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Gene Aliases: Cd4; L3T4; Ly-4

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UniProt ID: (Mouse) P06332

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Entrez Gene ID: (Mouse) 12504

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Function(s)

glycoprotein binding protein binding zinc ion binding coreceptor activity enzyme binding protein kinase binding protein homodimerization activity

Process(es)

cytokine production immune system process induction by virus of host cell-cell fusion immune response cell adhesion cell surface receptor signaling pathway T cell differentiation maintenance of protein location in cell T cell activation T cell selection protein palmitoleylation positive regulation of protein kinase activity positive regulation of peptidyl-tyrosine phosphorylation defense response to Gram-negative bacterium positive regulation of calcium-mediated signaling regulation of T cell activation positive regulation of T cell activation

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CD4 Monoclonal Antibody (GK1.5), eBioscience™

CD4 Antibody (14-0041-82) in Flow

Product Details

14-0041-82

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunohistochemistry (Frozen) (IHC (F))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Neutralization (Neu)

Functional Assay (Functional)

Miscellaneous PubMed (Misc)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

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RRID

Product Specific Information

Target Information

Bioinformatics

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