Product References
Prolidase Deficiency Causes Spontaneous T Cell Activation and Lupus-like Autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Hodgson R,Crockford TL,Bhandari A,Kepple JD,Back J,Cawthorne E,Abeler-Dörner L,Laing AG,Clare S,Speak A,Adams DJ,Dougan G,Hayday AC,Deobagkar-Lele M,Cornall RJ,Bull KR
25-0041-82 was used in Flow Cytometry to address the question of causation and show that Pepd-null mice have increased antinuclear autoantibodies and raised serum IgA, accompanied by kidney immune complex deposition, consistent with a systemic lupus erythematosus-like disease.
Wed Mar 01 00:00:00 EST 2023
HAPLN1 potentiates peritoneal metastasis in pancreatic cancer.
Nature communications
Wiedmann L,De Angelis Rigotti F,Vaquero-Siguero N,Donato E,Espinet E,Moll I,Alsina-Sanchis E,Bohnenberger H,Fernandez-Florido E,Mülfarth R,Vacca M,Gerwing J,Conradi LC,Ströbel P,Trumpp A,Mogler C,Fischer A,Rodriguez-Vita J
25-0041-82 was used in Flow cytometry/Cell sorting to identify hyaluronan and proteoglycan link protein-1 (HAPLN1) as a prognostic marker and as a driver for peritoneal metastasis in pancreatic ductal adenocarcinoma.
Mon Apr 24 00:00:00 EDT 2023
Identification of astrocyte regulators by nucleic acid cytometry.
Nature
Clark IC,Wheeler MA,Lee HG,Li Z,Sanmarco LM,Thaploo S,Polonio CM,Shin SW,Scalisi G,Henry AR,Rone JM,Giovannoni F,Charabati M,Akl CF,Aleman DM,Zandee SEJ,Prat A,Douek DC,Boritz EA,Quintana FJ,Abate AR
25-0041-82 was used in Flow cytometry/Cell sorting to develop focused interrogation of cells by nucleic acid detection and sequencing (FIND-seq), a high-throughput microfluidic cytometry method that combines encapsulation of cells in droplets, PCR-based detection of target nucleic acids and droplet sorting to enable in-depth transcriptomic analyses of cells of interest at single-cell resolution.
Wed Feb 01 00:00:00 EST 2023
Combined PARP and WEE1 inhibition triggers anti-tumor immune response in BRCA1/2 wildtype triple-negative breast cancer.
NPJ breast cancer
Teo ZL,O'Connor MJ,Versaci S,Clarke KA,Brown ER,Percy LW,Kuykhoven K,Mintoff CP,Savas P,Virassamy B,Luen SJ,Byrne A,Sant S,Lindeman GJ,Darcy PK,Loi S
25-0041-82 was used in Flow cytometry/Cell sorting to identify baseline tumour-infiltrating lymphocyte (TIL) levels as a potential predictive biomarker of response to PARPi, WEE1i and immunotherapies in BRCA1/2 wild-type TNBC.
Tue Aug 15 00:00:00 EDT 2023
R274X-mutated Phf6 increased the self-renewal and skewed T cell differentiation of hematopoietic stem cells.
iScience
Lan Y,Yuan S,Guo T,Hou S,Zhao F,Yang W,Cao Y,Chu Y,Jiang E,Yuan W,Wang X
25-0041-82 was used in Flow cytometry/Cell sorting to demonstrate that Phf6R274X plays a critical role in fine-tuning T cells and HSC homeostasis.
Fri Jun 16 00:00:00 EDT 2023
Development of a Syrian hamster anti-PD-L1 monoclonal antibody enables oncolytic adenoviral immunotherapy modelling in an immunocompetent virus replication permissive setting.
Frontiers in immunology
Clubb JHA,Kudling TV,Girych M,Haybout L,Pakola S,Hamdan F,Cervera-Carrascon V,Hemmes A,Grönberg-Vähä-Koskela S,Santos JM,Quixabeira DCA,Basnet S,Heiniö C,Arias V,Jirovec E,Kaptan S,Havunen R,Sorsa S,Erikat A,Schwartz J,Anttila M,Aro K,Viitala T,Vattulainen I,Cerullo V,Kanerva A,Hemminki A
25-0041-82 was used in Flow cytometry/Cell sorting to develop an anti-Syrian hamster PD-L1 mAb to enable the evaluation of safety and efficacy, when combining anti-PD-L1 with an oncolytic adenovirus encoding tumour necrosis factor alpha (TNFα) and interleukin-2 (IL-2) (Ad5/3-E2F-D24-hTNFα-IRES-hIL-2 or TILT-123).
Mon Feb 27 00:00:00 EST 2023
MCL-1 Inhibitor S63845 Distinctively Affects Intramedullary and Extramedullary Hematopoiesis.
Pharmaceutics
Zhang H,Li F,Yang M,Zhang W,He M,Xu H,Wang C,Zhang Y,Wang W,Gao Y,Du X,Li Y
25-0041-82 was used in Flow cytometry/Cell sorting to demonstrate the effects of myeloid cell leukemia 1 (MCL-1) inhibitor on the intramedullary and extramedullary hematopoietic lineages, which is important for the selection of combinations of antitumor drugs and the prevention of adverse hematopoiesis-related effects.
Tue Mar 28 00:00:00 EDT 2023
NDRG1 is induced by antigen-receptor signaling but dispensable for B and T cell self-tolerance.
Communications biology
Hodgson R,Xu X,Anzilotti C,Deobagkar-Lele M,Crockford TL,Kepple JD,Cawthorne E,Bhandari A,Cebrian-Serrano A,Wilcock MJ,Davies B,Cornall RJ,Bull KR
25-0041-82 was used in Flow cytometry/Cell sorting to find that B cell tolerance is maintained, and NDRG1 does not play a role in downstream responses during re-stimulation of in vivo antigen-experienced CD4+ T cells, demonstrating that NDGR1 is functionally redundant for lymphocyte anergy.
Thu Nov 10 00:00:00 EST 2022
Meningeal lymphatic drainage promotes T cell responses against Toxoplasma gondii but is dispensable for parasite control in the brain.
eLife
Kovacs MA,Cowan MN,Babcock IW,Sibley LA,Still K,Batista SJ,Labuzan SA,Sethi I,Harris TH
25-0041-82 was used in Flow cytometry/Cell sorting to reveal that CNS lymphatic drainage supports the development of peripheral T cell responses against T. gondii but remains dispensable for immune protection of the brain.
Wed Dec 21 00:00:00 EST 2022
RSV pre-fusion F protein enhances the G protein antibody and anti-infectious responses.
NPJ vaccines
Su C,Zhong Y,Zhao G,Hou J,Zhang S,Wang B
25-0041-82 was used in Flow cytometry/Cell sorting to show that combination of the FP4 peptide with the G protein and CsA provides a novel strategy for developing a safe and maximally effective recombinant G protein-containing RSV vaccine.
Mon Dec 19 00:00:00 EST 2022
Age-induced prostaglandin E2 impairs mitochondrial fitness and increases mortality to influenza infection.
Nature communications
Chen J,Deng JC,Zemans RL,Bahmed K,Kosmider B,Zhang M,Peters-Golden M,Goldstein DR
25-0041-82 was used in Flow cytometry/Cell sorting to identify prostaglandin E2 as a factor within the aged lung that compromise host defense to IAV by impairing the proliferation of alveolar macrophages.
Wed Nov 09 00:00:00 EST 2022
Intracellular Acetyl CoA Potentiates the Therapeutic Efficacy of Antitumor CD8+ T Cells.
Cancer research
Chowdhury S,Kar A,Bhowmik D,Gautam A,Basak D,Sarkar I,Ghosh P,Sarkar D,Deka A,Chakraborty P,Mukhopadhyay A,Mehrotra S,Basak S,Paul S,Chatterjee S
25-0041-82 was used in Flow cytometry/Cell sorting to delineate the metabolic configuration of CD8+ T cells required for stable effector function in tumors and present an affordable approach to promote the efficacy of CD8+ T cells for adoptive T-cell therapy.
Mon Jul 18 00:00:00 EDT 2022
Candida albicans oscillating UME6 expression during intestinal colonization primes systemic Th17 protective immunity.
Cell reports
Shao TY,Kakade P,Witchley JN,Frazer C,Murray KL,Ene IV,Haslam DB,Hagan T,Noble SM,Bennett RJ,Way SS
25-0041-82 was used in Flow cytometry/Cell sorting to show that dynamic gene expression fluctuations by C. albicans during symbiotic colonization are essential for priming host immunity against disseminated infection.
Tue May 17 00:00:00 EDT 2022
Porphyromonas gingivalis indirectly elicits intestinal inflammation by altering the gut microbiota and disrupting epithelial barrier function through IL9-producing CD4+ T cells.
Molecular oral microbiology
Sohn J,Li L,Zhang L,Settem RP,Honma K,Sharma A,Falkner KL,Novak JM,Sun Y,Kirkwood KL
25-0041-82 was used in Flow cytometry/Cell sorting to show the mechanism behind P. gingivalis-mediated intestinal inflammation where P. gingivalis indirectly induces intestinal IL9+ CD4+ T cells and inflammation by altering the gut microbiota.
Fri Apr 01 00:00:00 EDT 2022
Nose-Only Exposure to Cherry- and Tobacco-Flavored E-Cigarettes Induced Lung Inflammation in Mice in a Sex-Dependent Manner.
Toxics
Lamb T,Muthumalage T,Meehan-Atrash J,Rahman I
25-0041-82 was used in Flow cytometry/Cell sorting to reveal flavor- and sex-based e-cigarette effects in female mice exposed to cherry-flavored e-liquids and male mice exposed to tobacco-flavored e-liquids, namely, increased lung inflammation.
Sat Aug 13 00:00:00 EDT 2022
Gut-licensed IFNγ+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes.
Nature
Sanmarco LM,Wheeler MA,Gutiérrez-Vázquez C,Polonio CM,Linnerbauer M,Pinho-Ribeiro FA,Li Z,Giovannoni F,Batterman KV,Scalisi G,Zandee SEJ,Heck ES,Alsuwailm M,Rosene DL,Becher B,Chiu IM,Prat A,Quintana FJ
25-0041-82 was used in Flow Cytometry to show that LAMP1+TRAIL+ astrocytes limit CNS inflammation by inducing T cell apoptosis, and that this astrocyte subset is maintained by meningeal IFNγ+ NK cells that are licensed by the microbiome.
Mon Feb 01 00:00:00 EST 2021
Adenosine synthase A contributes to recurrent Staphylococcus aureus infection by dampening protective immunity.
EBioMedicine
Deng J,Zhang BZ,Chu H,Wang XL,Wang Y,Gong HR,Li R,Yang D,Li C,Dou Y,Gao P,Cai JP,Jin M,Du Q,Chan JF,Kao RY,Yuen KY,Huang JD
25-0041-82 was used in Flow Cytometry to investigate difference of pro-inflammatory responses and subsequent adaptive immune responses between adsA mutant and WT S. aureus strain infection.
Sun Aug 01 00:00:00 EDT 2021
Novel personalized cancer vaccine platform based on Bacillus Calmette-Guèrin.
Journal for immunotherapy of cancer
Ylösmäki E,Fusciello M,Martins B,Feola S,Hamdan F,Chiaro J,Ylösmäki L,Vaughan MJ,Viitala T,Kulkarni PS,Cerullo V
25-0041-82 was used in Flow cytometry/Cell sorting to warrant clinical testing of a novel cancer vaccine platform based on BCG.
Thu Jul 01 00:00:00 EDT 2021
A lymph node-targeted Amphiphile vaccine induces potent cellular and humoral immunity to SARS-CoV-2.
Science advances
Steinbuck MP,Seenappa LM,Jakubowski A,McNeil LK,Haqq CM,DeMuth PC
25-0041-82 was used in Flow Cytometry to evaluate an Amphiphile (AMP) vaccine adjuvant, AMP-CpG, composed of diacyl lipid-modified CpG, admixed with the SARS-CoV-2 Spike-2 receptor binding domain protein as a candidate vaccine (ELI-005) in mice.
Mon Feb 01 00:00:00 EST 2021
Colorectal cancer cells utilize autophagy to maintain mitochondrial metabolism for cell proliferation under nutrient stress.
JCI insight
Devenport SN,Singhal R,Radyk MD,Taranto JG,Kerk SA,Chen B,Goyert JW,Jain C,Das NK,Oravecz-Wilson K,Zhang L,Greenson JK,Chen YE,Soleimanpour SA,Reddy P,Lyssiotis CA,Shah YM
25-0041-82 was used in Flow Cytometry to demonstrate a cell-autonomous dependency of autophagy for cell growth in colorectal cancer.
Thu Jun 17 00:00:00 EDT 2021
Oncolytic Adenovirus Coding for a Variant Interleukin 2 (vIL-2) Cytokine Re-Programs the Tumor Microenvironment and Confers Enhanced Tumor Control.
Frontiers in immunology
Quixabeira DCA,Zafar S,Santos JM,Cervera-Carrascon V,Havunen R,Kudling TV,Basnet S,Anttila M,Kanerva A,Hemminki A
25-0041-82 was used in Flow Cytometry to conclude that Ad5/3-E2F-d24-vIL2 is a promising candidate for translation into clinical trials in human immunosuppressive solid tumors.
Fri Oct 15 00:00:00 EDT 2021
Immunogenicity and protective efficacy of an intranasal live-attenuated vaccine against SARS-CoV-2.
iScience
Park JG,Oladunni FS,Rohaim MA,Whittingham-Dowd J,Tollitt J,Hodges MDJ,Fathallah N,Assas MB,Alhazmi W,Almilaibary A,Iqbal M,Chang P,Escalona R,Shivanna V,Torrelles JB,Worthington JJ,Jackson-Jones LH,Martinez-Sobrido L,Munir M
25-0041-82 was used in Flow Cytometry to evaluate a Newcastle disease virus (NDV)-based vectored-vaccine in mice and hamsters for its immunogenicity, safety and protective efficacy against SARS-CoV-2.
Fri Sep 24 00:00:00 EDT 2021
IDO1 Expression in Ovarian Cancer Induces PD-1 in T Cells via Aryl Hydrocarbon Receptor Activation.
Frontiers in immunology
Amobi-McCloud A,Muthuswamy R,Battaglia S,Yu H,Liu T,Wang J,Putluri V,Singh PK,Qian F,Huang RY,Putluri N,Tsuji T,Lugade AA,Liu S,Odunsi K
25-0041-82 was used in Flow Cytometry to enable the design of strategies to target the IDO1 and AHR pathways for enhancing anti-tumor immunity in ovarian cancer.
Fri Oct 29 00:00:00 EDT 2021
Novel oncolytic adenovirus expressing enhanced cross-hybrid IgGA Fc PD-L1 inhibitor activates multiple immune effector populations leading to enhanced tumor killing in vitro, in vivo and with patient-derived tumor organoids.
Journal for immunotherapy of cancer
Hamdan F,Ylösmäki E,Chiaro J,Giannoula Y,Long M,Fusciello M,Feola S,Martins B,Feodoroff M,Antignani G,Russo S,Kari O,Lee M,Järvinen P,Nisen H,Kreutzman A,Leusen J,Mustjoki S,McWilliams TG,Grönholm M,Cerullo V
25-0041-82 was used in Flow cytometry/Cell sorting to designed an oncolytic adenovirus to increase efficacy while minimizing toxicity of PD-L1 immunecheckpoint therapy that secretes a cross-hybrid Fc-fusion peptide against PD-L1 able to elicit effector mechanisms of an IgG1 and also IgA1 consequently activating neutrophils, a population neglected by IgG1, in order to combine multiple effector mechanisms.
Sun Aug 01 00:00:00 EDT 2021
Activation of regulatory T cells triggers specific changes in glycosylation associated with Siglec-1-dependent inflammatory responses.
Wellcome open research
Wu G,Murugesan G,Nagala M,McCraw A,Haslam SM,Dell A,Crocker PR
25-0041-82 was used in Flow Cytometry to investigate the molecular basis for Siglec-1 binding to regulatory T cells using in vitro-induced cells as a model system.
Tue Mar 01 00:00:00 EST 2022
Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist.
eLife
Glassman CR,Su L,Majri-Morrison SS,Winkelmann H,Mo F,Li P,Pérez-Cruz M,Ho PP,Koliesnik I,Nagy N,Hnizdilova T,Picton LK,Kovar M,Bollyky P,Steinman L,Meyer E,Piehler J,Leonard WJ,Garcia KC
25-0041 was used in Flow cytometry/Cell sorting to show that cytokine partial agonists can be used to calibrate intrinsic differences in response thresholds across responding cell types to narrow pleiotropic actions, which may be generalizable to other cytokine and growth factor systems.
Tue May 18 00:00:00 EDT 2021
Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection.
Nature immunology
Aegerter H,Kulikauskaite J,Crotta S,Patel H,Kelly G,Hessel EM,Mack M,Beinke S,Wack A
25-0041-82 was used in Flow Cytometry to understand how transient respiratory infections, a common occurrence in human life, can constantly alter lung immunity by contributing monocyte-derived, recruited cells to the AM population.
Sat Feb 01 00:00:00 EST 2020
Snai2 Maintains Bone Marrow Niche Cells by Repressing Osteopontin Expression.
Developmental cell
Wei Q,Nakahara F,Asada N,Zhang D,Gao X,Xu C,Alfieri A,Brodin NP,Zimmerman SE,Mar JC,Guha C,Guo W,Frenette PS
25-0041-82 was used in Flow Cytometry to conclude that SNAI2 is a critical regulator of the transcriptional network maintaining MSPCs by the suppression of osteopontin expression.
Mon Jun 08 00:00:00 EDT 2020
Astrocytes promote a protective immune response to brain Toxoplasma gondii infection via IL-33-ST2 signaling.
PLoS pathogens
Still KM,Batista SJ,O'Brien CA,Oyesola OO,Früh SP,Webb LM,Smirnov I,Kovacs MA,Cowan MN,Hayes NW,Thompson JA,Tait Wojno ED,Harris TH
25-0041 was used in Flow cytometry/Cell sorting to show that IL-33 is expressed by oligodendrocytes and astrocytes during T. gondii infection, is released locally into the cerebrospinal fluid of T. gondii-infected animals, and is required for control of infection.
Thu Oct 01 00:00:00 EDT 2020
MRI of tumor T cell infiltration in response to checkpoint inhibitor therapy.
Journal for immunotherapy of cancer
Jiang X,Dudzinski S,Beckermann KE,Young K,McKinley E,J McIntyre O,Rathmell JC,Xu J,Gore JC
25-0041-82 was used in Flow Cytometry to propose an innovative concept that a sufficiently large influx of tumor infiltrating T cells, which have a smaller diameter than cancer cells, will change the diameter distribution and decrease the average size of cells within a volume to a degree that can be quantified by non-invasive MRI.
Mon Jun 01 00:00:00 EDT 2020
FUT1 deficiency elicits immune dysregulation and corneal opacity in steady state and under stress.
Cell death & disease
Kim KW,Ryu JS,Ko JH,Kim JY,Kim HJ,Lee HJ,Oh JH,Chung JH,Oh JY
25-0041 was used in Flow cytometry/Cell sorting to investigate the effects of FUT1 on the ocular surface in steady-state conditions with age and under desiccating stress using a Fut1 knockout (KO) mouse model.
Fri Apr 24 00:00:00 EDT 2020
Identification of atypical mitogen-activated protein kinase MAPK4 as a novel regulator in acute lung injury.
Cell & bioscience
Mao L,Zhou Y,Chen L,Hu L,Liu S,Zheng W,Zhao J,Guo M,Chen C,He Z,Xu L
25-0041-82 was used in Flow Cytometry to reveal an unknown role of atypical MAPKs member MAPK4 in the pathology of acute lung injury.
Sun Apr 17 00:00:00 EDT 2022
Comparative Analysis of Age-Related Changes in Lacrimal Glands and Meibomian Glands of a C57BL/6 Male Mouse Model.
International journal of molecular sciences
Yoon CH,Ryu JS,Hwang HS,Kim MK
25-0041 was used in Flow cytometry/Cell sorting to suggest that age-dependent DED in C57BL/6 mice is related to inflammation of the LGs, the development of MG atrophy, and oxidative stress in both glands.
Thu Jun 11 00:00:00 EDT 2020
Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target.
JCI insight
Pierini S,Tanyi JL,Simpkins F,George E,Uribe-Herranz M,Drapkin R,Burger R,Morgan MA,Facciabene A
25-0041 was used in Flow cytometry/Cell sorting to study can serve as a foundation for trials testing immunotherapeutic approaches in patients with ovarian GCT.
Thu Aug 20 00:00:00 EDT 2020
E-cigarette-induced pulmonary inflammation and dysregulated repair are mediated by nAChR α7 receptor: role of nAChR α7 in SARS-CoV-2 Covid-19 ACE2 receptor regulation.
Respiratory research
Wang Q,Sundar IK,Li D,Lucas JH,Muthumalage T,McDonough SR,Rahman I
25-0041 was used in Flow cytometry/Cell sorting to investigate if sub-chronic e-cig exposure induces inflammatory response and dysregulated repair/extracellular matrix (ECM) remodeling, through the α7 nicotinic acetylcholine receptor (nAChRα7).
Thu Jun 18 00:00:00 EDT 2020
Interaction of Deubiquitinase 2A-DUB/MYSM1 with DNA Repair and Replication Factors.
International journal of molecular sciences
Kroeger C,Roesler R,Wiese S,Hainzl A,Gatzka MV
25-0041 was used in Flow cytometry/Cell sorting to provide additional evidence for an interaction between MYSM1 and key DNA replication and repair factors, and indicate a potential function of 2A-DUB/MYSM1 in DNA repair processes.
Tue May 26 00:00:00 EDT 2020
E-cigarette-Induced Pulmonary Inflammation and Dysregulated Repair are Mediated by nAChR α7 Receptor: Role of nAChR α7 in ACE2 Covid-19 receptor regulation.
Research square
Wang Q,Sundar I,Li D,Lucas J,Muthumalage T,McDonough S,Rahman I
25-0041 was used in Flow cytometry/Cell sorting to demostarte that sub-chronic e-cig exposure with or without nicotine affect lung inflammation and repair responses/ECM remodeling, which are mediated by nAChR α7 in a sex-dependent manner.
Mon May 18 00:00:00 EDT 2020
Bone Morphogenic Proteins Are Immunoregulatory Cytokines Controlling FOXP3+ Treg Cells.
Cell reports
Browning LM,Miller C,Kuczma M,Pietrzak M,Jing Y,Rempala G,Muranski P,Ignatowicz L,Kraj P
25-0041-82 was used in Flow Cytometry to establish that BMPs, a large cytokine family, are an essential link between stromal tissues and the adaptive immune system involved in sustaining tissue homeostasis by promoting immunological tolerance.
Tue Oct 06 00:00:00 EDT 2020
Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10.
Cell
Rojas OL,Pröbstel AK,Porfilio EA,Wang AA,Charabati M,Sun T,Lee DSW,Galicia G,Ramaglia V,Ward LA,Leung LYT,Najafi G,Khaleghi K,Garcillán B,Li A,Besla R,Naouar I,Cao EY,Chiaranunt P,Burrows K,Robinson HG,Allanach JR,Yam J,Luck H,Campbell DJ,Allman D,Brooks DG,Tomura M,Baumann R,Zamvil SS,Bar-Or A,Horwitz MS,Winer DA,Mortha A,Mackay F,Prat A,Osborne LC,Robbins C,Baranzini SE,Gommerman JL
25-0041-82 was used in Flow Cytometry to show that IgA+ plasmablast and/or plasma cells mobilized from the gut play an role in suppressing neuroinflammation.
Thu Jan 24 00:00:00 EST 2019
Polychromic Reporter Mice Reveal Unappreciated Innate Lymphoid Cell Progenitor Heterogeneity and Elusive ILC3 Progenitors in Bone Marrow.
Immunity
Walker JA,Clark PA,Crisp A,Barlow JL,Szeto A,Ferreira ACF,Rana BMJ,Jolin HE,Rodriguez-Rodriguez N,Sivasubramaniam M,Pannell R,Cruickshank J,Daly M,Haim-Vilmovsky L,Teichmann SA,McKenzie ANJ
25-0041 was used in Flow cytometry/Cell sorting to identify a discrete ILC2-committed population and delineated transition states between early progenitors and a highly heterogeneous ILC1, ILC3, and NK precursor cell cluster.
Tue Jul 16 00:00:00 EDT 2019
Engineering a haematopoietic stem cell niche by revitalizing mesenchymal stromal cells.
Nature cell biology
Nakahara F,Borger DK,Wei Q,Pinho S,Maryanovich M,Zahalka AH,Suzuki M,Cruz CD,Wang Z,Xu C,Boulais PE,Ma'ayan A,Greally JM,Frenette PS
25-0041-82 was used in Flow Cytometry to provide insight into the transcriptional regulation of the niche with implications for stem cell-based therapies.
Wed May 01 00:00:00 EDT 2019
miR-181a/b-1 controls thymic selection of Treg cells and tunes their suppressive capacity.
PLoS biology
Łyszkiewicz M,Winter SJ,Witzlau K,Föhse L,Brownlie R,Puchałka J,Verheyden NA,Kunze-Schumacher H,Imelmann E,Blume J,Raha S,Sekiya T,Yoshimura A,Frueh JT,Ullrich E,Huehn J,Weiss S,Gutierrez MG,Prinz I,Zamoyska R,Ziętara N,Krueger A
25-0041-82 was used in Flow Cytometry to propose that intrathymic miR-181a/b-1 controls development of Treg cells and imposes a developmental legacy on their peripheral function.
Fri Mar 01 00:00:00 EST 2019
Autophagy Regulation of Metabolism Is Required for CD8+ T Cell Anti-tumor Immunity.
Cell reports
DeVorkin L,Pavey N,Carleton G,Comber A,Ho C,Lim J,McNamara E,Huang H,Kim P,Zacharias LG,Mizushima N,Saitoh T,Akira S,Beckham W,Lorzadeh A,Moksa M,Cao Q,Murthy A,Hirst M,DeBerardinis RJ,Lum JJ
25-0041 was used in Flow cytometry/Cell sorting to demonstrate a cell-autonomous role for autophagy in the regulation of CD8+ T-cell-mediated control of tumors.
Tue Apr 09 00:00:00 EDT 2019
Interleukin-27 Is Essential for Type 1 Diabetes Development and Sjögren Syndrome-like Inflammation.
Cell reports
Ciecko AE,Foda B,Barr JY,Ramanathan S,Atkinson MA,Serreze DV,Geurts AM,Lieberman SM,Chen YG
25-0041-82 was used in Flow Cytometry to reveal that IL-27 contributes to autoimmunity in NOD mice through multiple mechanisms and provides substantial evidence to support its pathogenic role in human T1D.
Tue Dec 03 00:00:00 EST 2019
Checkpoint blockade and nanosonosensitizer-augmented noninvasive sonodynamic therapy combination reduces tumour growth and metastases in mice.
Nature communications
Yue W,Chen L,Yu L,Zhou B,Yin H,Ren W,Liu C,Guo L,Zhang Y,Sun L,Zhang K,Xu H,Chen Y
25-0041 was used in Flow cytometry/Cell sorting to demonstrate how a combination of nanosonosensitiser-augmented sonodynamic and anti-PD-L1 checkpoint blockade therapy deliver highly efficient tumour therapy in mice.
Thu May 02 00:00:00 EDT 2019
Intestinal non-canonical NFκB signaling shapes the local and systemic immune response.
Nature communications
Ramakrishnan SK,Zhang H,Ma X,Jung I,Schwartz AJ,Triner D,Devenport SN,Das NK,Xue X,Zeng MY,Hu Y,Mortensen RM,Greenson JK,Cascalho M,Wobus CE,Colacino JA,Nunez G,Rui L,Shah YM
25-0041 was used in Flow cytometry/Cell sorting to determine the role of Microfold cells in systemic inflammatory responses.
Fri Feb 08 00:00:00 EST 2019
Expression of the Phosphatase Ppef2 Controls Survival and Function of CD8+ Dendritic Cells.
Frontiers in immunology
Zwick M,Ulas T,Cho YL,Ried C,Grosse L,Simon C,Bernhard C,Busch DH,Schultze JL,Buchholz VR,Stutte S,Brocker T
25-0041-82 was used in Flow Cytometry to suggest that Ppef2 is crucial to support survival of immature CD8+ DCs, while Ppef2 down-regulation during DC-maturation limits T cell responses.
Tue Oct 27 00:00:00 EDT 2020
Restricted Expression of the Thymoproteasome Is Required for Thymic Selection and Peripheral Homeostasis of CD8+ T Cells.
Cell reports
Tomaru U,Konno S,Miyajima S,Kimoto R,Onodera M,Kiuchi S,Murata S,Ishizu A,Kasahara M
25-0041 was used in Flow cytometry/Cell sorting to find that thymoproteasomes are essential for positive selection but that the subsequent change in peptide repertoire in the medulla is also crucial for thymic selection and that β5t-derived peptide must be confined to the thymus to avoid autoimmunity in peripheral tissues.
Tue Jan 15 00:00:00 EST 2019
Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche.
Nature medicine
Maryanovich M,Zahalka AH,Pierce H,Pinho S,Nakahara F,Asada N,Wei Q,Wang X,Ciero P,Xu J,Leftin A,Frenette PS
25-0041 was used in Flow cytometry/Cell sorting to determine whether haematopoietic stem cell ageing depends on bone marrow innervation by the sympathetic nervous system.
Fri Jun 01 00:00:00 EDT 2018
Loss of NF-κB1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner.
Immunity
O'Reilly LA,Putoczki TL,Mielke LA,Low JT,Lin A,Preaudet A,Herold MJ,Yaprianto K,Tai L,Kueh A,Pacini G,Ferrero RL,Gugasyan R,Hu Y,Christie M,Wilcox S,Grumont R,Griffin MDW,O'Connor L,Smyth GK,Ernst M,Waring P,Gerondakis S,Strasser A
25-0041-82 was used in Flow Cytometry to provide mechanistic insight into how polymorphisms that attenuate NFKB1 expression predispose humans to epithelial cancers, highlighting the pro-tumorigenic activity of STAT1 and identifying targetable vulnerabilities in gastric cancer.
Tue Mar 20 00:00:00 EDT 2018
Foxp3 expression in induced regulatory T cells is stabilized by C/EBP in inflammatory environments.
EMBO reports
Lee S,Park K,Kim J,Min H,Seong RH
25-0041 was used in Flow cytometry/Cell sorting to show CCAAT/enhancer-binding protein can enhance TGF-β-induced Foxp3+ regulatory T cell generation.
Sat Dec 01 00:00:00 EST 2018
Role of TFH Cells in Promoting T Helper 17-Induced Neuroinflammation.
Frontiers in immunology
Quinn JL,Kumar G,Agasing A,Ko RM,Axtell RC
25-0041 was used in Flow cytometry/Cell sorting to study how T and B cells cooperate in the pathogenesis of multiple sclerosis.
Mon Apr 08 00:00:00 EDT 2019
De Novo Fatty Acid Synthesis During Mycobacterial Infection Is a Prerequisite for the Function of Highly Proliferative T Cells, But Not for Dendritic Cells or Macrophages.
Frontiers in immunology
Stüve P,Minarrieta L,Erdmann H,Arnold-Schrauf C,Swallow M,Guderian M,Krull F,Hölscher A,Ghorbani P,Behrends J,Abraham WR,Hölscher C,Sparwasser TD,Berod L
25-0041-82 was used in Flow Cytometry to reveal that acetyl-CoA carboxylase 1-dependent fatty acid synthesis is a crucial mechanism in T cells, but not dendritic cells or macrophages, to fight against mycobacterial infection.
Wed Apr 10 00:00:00 EDT 2019
Macrophages orchestrate breast cancer early dissemination and metastasis.
Nature communications
Linde N,Casanova-Acebes M,Sosa MS,Mortha A,Rahman A,Farias E,Harper K,Tardio E,Reyes Torres I,Jones J,Condeelis J,Merad M,Aguirre-Ghiso JA
25-0041 was used in Flow cytometry/Cell sorting to show that, in pre-malignant lesions, CCL2 produced by cancer cells and myeloid cells attracts CD206+/Tie2+macrophages and induces Wnt-1 upregulation that in turn downregulates E-cadherin junctions in the HER2+early cancer cells.
Tue Jan 02 00:00:00 EST 2018
Pyruvate dehydrogenase complex stimulation promotes immunometabolic homeostasis and sepsis survival.
JCI insight
McCall CE,Zabalawi M,Liu T,Martin A,Long DL,Buechler NL,Arts RJW,Netea M,Yoza BK,Stacpoole PW,Vachharajani V
25-0041 was used in Flow cytometry/Cell sorting to assess the pyruvate dehydrogenase complex/pyruvate dehydrogenase kinase 1 axis as a druggable mitochondrial target for promoting immunometabolic and organ homeostasis during sepsis.
Thu Aug 09 00:00:00 EDT 2018
Lack of FcRn Impairs Natural Killer Cell Development and Functions in the Tumor Microenvironment.
Frontiers in immunology
Castaneda DC,Dhommée C,Baranek T,Dalloneau E,Lajoie L,Valayer A,Arnoult C,Demattéi MV,Fouquenet D,Parent C,Heuzé-Vourc'h N,Gouilleux-Gruart V
25-0041 was used in Flow cytometry/Cell sorting to elucidate the consequences of neonatal Fc receptor down-regulation in the anti-tumour immune response.
Mon Oct 21 00:00:00 EDT 2019
CD69 enhances immunosuppressive function of regulatory T-cells and attenuates colitis by prompting IL-10 production.
Cell death & disease
Yu L,Yang F,Zhang F,Guo D,Li L,Wang X,Liang T,Wang J,Cai Z,Jin H
25-0041 was used in Flow cytometry/Cell sorting to study the importance of the C-type lectin receptor CD69 to the suppressive function of Tregs.
Wed Sep 05 00:00:00 EDT 2018
Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy.
Cell
Cabezas-Wallscheid N,Buettner F,Sommerkamp P,Klimmeck D,Ladel L,Thalheimer FB,Pastor-Flores D,Roma LP,Renders S,Zeisberger P,Przybylla A,Schönberger K,Scognamiglio R,Altamura S,Florian CM,Fawaz M,Vonficht D,Tesio M,Collier P,Pavlinic D,Geiger H,Schroeder T,Benes V,Dick TP,Rieger MA,Stegle O,Trumpp A
25-0041 was used in Flow cytometry/Cell sorting to highlight the impact of dietary vitamin A on the regulation of cell-cycle-mediated stem cell plasticity.
Thu May 18 00:00:00 EDT 2017
Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA.
Immunity
Coelho MA,de Carné Trécesson S,Rana S,Zecchin D,Moore C,Molina-Arcas M,East P,Spencer-Dene B,Nye E,Barnouin K,Snijders AP,Lai WS,Blackshear PJ,Downward J
25-0041-82 was used in Flow Cytometry to demonstrate that RAS can drive cell-intrinsic PD-L1 expression, thus presenting therapeutic opportunities to reverse the innately immunoresistant phenotype of RAS mutant cancers.
Tue Dec 19 00:00:00 EST 2017
Glucocorticoid receptor in T cells mediates protection from autoimmunity in pregnancy.
Proceedings of the National Academy of Sciences of the United States of America
Engler JB,Kursawe N,Solano ME,Patas K,Wehrmann S,Heckmann N,Lühder F,Reichardt HM,Arck PC,Gold SM,Friese MA
25-0041 was used in Flow cytometry/Cell sorting to study the endocrine regulation of conventional and regulatory T cells during reproduction.
Tue Jan 10 00:00:00 EST 2017
In vivo activation of latent HIV with a synthetic bryostatin analog effects both latent cell "kick" and "kill" in strategy for virus eradication.
PLoS pathogens
Marsden MD,Loy BA,Wu X,Ramirez CM,Schrier AJ,Murray D,Shimizu A,Ryckbosch SM,Near KE,Chun TW,Wender PA,Zack JA
25-0041 was used in Flow cytometry/Cell sorting to show that cells latently-infected by HIV exhibit both "kick" and "kill" strategies upon virus reactivation with a bryostatin 1 analogue.
Fri Sep 01 00:00:00 EDT 2017
Cooperation of Gastric Mononuclear Phagocytes with Helicobacter pylori during Colonization.
Journal of immunology (Baltimore, Md. : 1950)
Viladomiu M,Bassaganya-Riera J,Tubau-Juni N,Kronsteiner B,Leber A,Philipson CW,Zoccoli-Rodriguez V,Hontecillas R
25-0041 was used in Flow cytometry/Cell sorting to report the induction of IL-10-driven regulatory responses mediated by CD11b+F4/80hiCD64+CX3CR1+ MNPs that contribute to maintaining high levels of Helicobacter pylori loads in the stomach by modulating effector T cell responses at the gastric mucosa.
Sat Apr 15 00:00:00 EDT 2017
Intragastric administration of Lactobacillus casei BL23 induces regulatory FoxP3+RORγt+ T cells subset in mice.
Beneficial microbes
Cortes-Perez NG,Lozano-Ojalvo D,Maiga MA,Hazebrouck S,Adel-Patient K
25-0041 was used in Flow cytometry/Cell sorting to investigate the mechanisms behind the immunomodulatory properties of the probiotic bacterial strain, Lactobacillus casei BL23.
Tue May 30 00:00:00 EDT 2017
Lithocholic acid controls adaptive immune responses by inhibition of Th1 activation through the Vitamin D receptor.
PloS one
Pols TWH,Puchner T,Korkmaz HI,Vos M,Soeters MR,de Vries CJM
25-0041 was used in Flow cytometry/Cell sorting to study the mechanism by which lithocholic acid controls adaptive immunity.
Mon Sep 11 00:00:00 EDT 2017
Lymphatic vessels regulate immune microenvironments in human and murine melanoma.
The Journal of clinical investigation
Lund AW,Wagner M,Fankhauser M,Steinskog ES,Broggi MA,Spranger S,Gajewski TF,Alitalo K,Eikesdal HP,Wiig H,Swartz MA
25-0041 was used in Flow cytometry/Cell sorting to suggest that the establishment of tumour-associated inflammation and immunity critically depends on lymphatic vessel remodelling and drainage.
Thu Sep 01 00:00:00 EDT 2016
mTOR has distinct functions in generating versus sustaining humoral immunity.
The Journal of clinical investigation
Jones DD,Gaudette BT,Wilmore JR,Chernova I,Bortnick A,Weiss BM,Allman D
25-0041 was used in Flow cytometry/Cell sorting to conclude that mTOR signalling plays critical but diverse roles in early and late phases of antibody responses and plasma cell differentiation.
Tue Nov 01 00:00:00 EDT 2016
IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization.
The Journal of experimental medicine
Yoon J,Leyva-Castillo JM,Wang G,Galand C,Oyoshi MK,Kumar L,Hoff S,He R,Chervonsky A,Oppenheim JJ,Kuchroo VK,van den Brink MR,Malefyt Rde W,Tessier PA,Fuhlbrigge R,Rosenstiel P,Terhorst C,Murphy G,Geha RS
25-0041 was used in Flow cytometry/Cell sorting to elucidate the mechanisms behind DC-derived IL-23 in a model of skin inflammation.
Mon Sep 19 00:00:00 EDT 2016
Monocyte Adhesion and Plaque Recruitment During Atherosclerosis Development Is Regulated by the Adapter Protein Chat-H/SHEP1.
Arteriosclerosis, thrombosis, and vascular biology
Herbin O,Regelmann AG,Ramkhelawon B,Weinstein EG,Moore KJ,Alexandropoulos K
25-0041 was used in Flow cytometry/Cell sorting to analyse the role of Chat-H in atherosclerosis development, showing that monocyte adhesion and plaque recruitment is regulated by Chat-H/SHEP1.
Thu Sep 01 00:00:00 EDT 2016
Protein Translation Activity: A New Measure of Host Immune Cell Activation.
Journal of immunology (Baltimore, Md. : 1950)
Seedhom MO,Hickman HD,Wei J,David A,Yewdell JW
25-0041 was used in Flow cytometry/Cell sorting to describe the in vivo ribopuromycylation method.
Mon Aug 15 00:00:00 EDT 2016
Evaluation of the irritancy and hypersensitivity potential following topical application of didecyldimethylammonium chloride.
Journal of immunotoxicology
Anderson SE,Shane H,Long C,Lukomska E,Meade BJ,Marshall NB
25-0041 was used in Flow cytometry/Cell sorting to investigate the irritancy and hypersensivity potential of didecyldimethylammonium chloride (DDAC).
Fri Jul 01 00:00:00 EDT 2016
Tumour suppressor death-associated protein kinase targets cytoplasmic HIF-1α for Th17 suppression.
Nature communications
Chou TF,Chuang YT,Hsieh WC,Chang PY,Liu HY,Mo ST,Hsu TS,Miaw SC,Chen RH,Kimchi A,Lai MZ
25-0041 was used in Western Blotting to study tumour suppressor death-associated protein kinases as treatments for Th17-associated inflammatory diseases.
Fri Jun 17 00:00:00 EDT 2016
Alkylator-Induced and Patient-Derived Xenograft Mouse Models of Therapy-Related Myeloid Neoplasms Model Clinical Disease and Suggest the Presence of Multiple Cell Subpopulations with Leukemia Stem Cell Activity.
PloS one
Jonas BA,Johnson C,Gratzinger D,Majeti R
25-0041 was used in Flow cytometry/Cell sorting to report several new t-AML/MDS mouse models that could potentially be used to further define disease pathogenesis and test novel therapeutics.
Wed Jul 26 00:00:00 EDT 2017
FOXP3+ Regulatory T Cells in Hepatic Fibrosis and Splenomegaly Caused by Schistosoma japonicum: The Spleen May Be a Major Source of Tregs in Subjects with Splenomegaly.
PLoS neglected tropical diseases
Romano A,Hou X,Sertorio M,Dessein H,Cabantous S,Oliveira P,Li J,Oyegue S,Arnaud V,Luo X,Daujat-Chavanieu M,Mariani O,Sastre X,Dombey AM,He H,Li Y,Dessein A
25-0041-82 was used in Flow cytometry/Cell sorting to investigate whether FOXP3+ Tregs play a role in human schistosomiasis.
Fri Jan 01 00:00:00 EST 2016
Mycobacterium tuberculosis multistage antigens confer comprehensive protection against pre- and post-exposure infections by driving Th1-type T cell immunity.
Oncotarget
Ma J,Tian M,Fan X,Yu Q,Jing Y,Wang W,Li L,Zhou Z
25-0041 was used in Flow cytometry/Cell sorting to suggest that multistage-specific antigens could be targets for the next generation TB vaccine.
Tue Sep 27 00:00:00 EDT 2016
Alternative splicing of MALT1 controls signalling and activation of CD4(+) T cells.
Nature communications
Meininger I,Griesbach RA,Hu D,Gehring T,Seeholzer T,Bertossi A,Kranich J,Oeckinghaus A,Eitelhuber AC,Greczmiel U,Gewies A,Schmidt-Supprian M,Ruland J,Brocker T,Heissmeyer V,Heyd F,Krappmann D
25-0041 was used in Flow cytometry/Cell sorting to study how TCR-induced alternative splicing augments MALT1 scaffolding to enhance downstream signalling and to promote optimal T-cell activation.
Tue Apr 12 00:00:00 EDT 2016
Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination.
Nature neuroscience
Haines JD,Herbin O,de la Hera B,Vidaurre OG,Moy GA,Sun Q,Fung HY,Albrecht S,Alexandropoulos K,McCauley D,Chook YM,Kuhlmann T,Kidd GJ,Shacham S,Casaccia P
25-0041 was used in Flow cytometry/Cell sorting to reveal that CRM1 inhibitors have the ability to modulate the export of molecules associated with both axonal damage and also neuroprotection.
Wed Apr 01 00:00:00 EDT 2015
An anti-silencer- and SATB1-dependent chromatin hub regulates Rag1 and Rag2 gene expression during thymocyte development.
The Journal of experimental medicine
Hao B,Naik AK,Watanabe A,Tanaka H,Chen L,Richards HW,Kondo M,Taniuchi I,Kohwi Y,Kohwi-Shigematsu T,Krangel MS
25-0041 was used in Flow cytometry/Cell sorting to provide a novel framework for understanding ASE function for gene expression in double-positive thymocytes.
Mon May 04 00:00:00 EDT 2015
ADAP and SKAP55 deficiency suppresses PD-1 expression in CD8+ cytotoxic T lymphocytes for enhanced anti-tumor immunotherapy.
EMBO molecular medicine
Li C,Li W,Xiao J,Jiao S,Teng F,Xue S,Zhang C,Sheng C,Leng Q,Rudd CE,Wei B,Wang H
25-0041 was used in Flow cytometry/Cell sorting to investigate the effects of the ADAP-SKAP55 signaling module on cytotoxicity, PD-1 expression, and anti-tumour immunity.
Mon Jun 01 00:00:00 EDT 2015
IL-27 Signaling Is Crucial for Survival of Mice Infected with African Trypanosomes via Preventing Lethal Effects of CD4+ T Cells and IFN-γ.
PLoS pathogens
Liu G,Xu J,Wu H,Sun D,Zhang X,Zhu X,Magez S,Shi M
25-0041 was used in Flow cytometry/Cell sorting to investigate the role of IL-27 in African trypanosomes infection, showing that IL-27 signalling is crucial by preventing lethal effects of CD4+ T cells and IFN-γ.
Wed Jul 01 00:00:00 EDT 2015
MHC class II presentation is controlled by the lysosomal small GTPase, Arl8b.
Journal of immunology (Baltimore, Md. : 1950)
Michelet X,Garg S,Wolf BJ,Tuli A,Ricciardi-Castagnoli P,Brenner MB
25-0041 was used in Flow cytometry/Cell sorting to highlight the role of Arl8b as a trafficking regulator of the late stage of MHC II-peptide complex formation and MHC II presentation in DCs.
Sun Mar 01 00:00:00 EST 2015
Chronic oral infection with major periodontal bacteria Tannerella forsythia modulates systemic atherosclerosis risk factors and inflammatory markers.
Pathogens and disease
Chukkapalli SS,Rivera-Kweh MF,Velsko IM,Chen H,Zheng D,Bhattacharyya I,Gangula PR,Lucas AR,Kesavalu L
25-0041 was used in Flow cytometry/Cell sorting to investigate the potential of a known bacterial pathogen found in atherosclerotic plaque in humans to accelerate atherosclerosis in hyperlipdemic mice.
Wed Apr 01 00:00:00 EDT 2015
Basophil-associated OX40 ligand participates in the initiation of Th2 responses during airway inflammation.
The Journal of biological chemistry
Di C,Lin X,Zhang Y,Zhong W,Yuan Y,Zhou T,Liu J,Xia Z
25-0041 was used in Flow cytometry/Cell sorting to demonstrate that basophils prime Th2 responses via OX40-OX40L interaction in asthma.
Fri May 15 00:00:00 EDT 2015
Excessive proliferation and impaired function of primitive hematopoietic cells in bone marrow due to senescence post chemotherapy in a T cell acute lymphoblastic leukemia model.
Journal of translational medicine
Jiang C,Hu X,Wang L,Cheng H,Lin Y,Pang Y,Yuan W,Cheng T,Wang J
25-0041 was used in Flow cytometry/Cell sorting to conclude that primitive hematopoietic cells in bone marrow enter proliferation earlier than leukemic cells after chemotherapy, and gradually lose their regenerative capacity partly by senescence due to accelerated cycling.
Fri Jul 17 00:00:00 EDT 2015
Differential Contribution of Acute and Chronic Inflammation to the Development of Murine Mammary 4T1 Tumors.
PloS one
Rodrigues Viana CT,Castro PR,Marques SM,Paz Lopes MT,Gonçalves R,Campos PP,Andrade SP
25-0041 was used in Flow cytometry/Cell sorting to investigate the influence of acute and chronic inflammation on the development of a murine mammary tumour.
Mon Apr 18 00:00:00 EDT 2016
Polymicrobial Oral Infection with Four Periodontal Bacteria Orchestrates a Distinct Inflammatory Response and Atherosclerosis in ApoE null Mice.
PloS one
Chukkapalli SS,Velsko IM,Rivera-Kweh MF,Zheng D,Lucas AR,Kesavalu L
25-0041 was used in Flow cytometry/Cell sorting to study the levels of inflammatory molecules and cells types involved in mounting an immune response to peridontal infection over time.
Fri Jun 17 00:00:00 EDT 2016
Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion.
Nature medicine
Bruns I,Lucas D,Pinho S,Ahmed J,Lambert MP,Kunisaki Y,Scheiermann C,Schiff L,Poncz M,Bergman A,Frenette PS
25-0041 was used in Flow cytometry/Cell sorting to indicate that a terminally differentiated cell type derived from HSCs contributes to the HSC niche, directly regulating HSC behavior.
Sat Nov 01 00:00:00 EDT 2014
Mycobacteria manipulate macrophage recruitment through coordinated use of membrane lipids.
Nature
Cambier CJ,Takaki KK,Larson RP,Hernandez RE,Tobin DM,Urdahl KB,Cosma CL,Ramakrishnan L
25-0041 was used in Flow cytometry/Cell sorting to show, in mice and zebrafish, that M. tuberculosis preferentially recruits and infects permissive macrophages while evading microbicidal ones.
Thu Jan 09 00:00:00 EST 2014
CCR10 regulates balanced maintenance and function of resident regulatory and effector T cells to promote immune homeostasis in the skin.
The Journal of allergy and clinical immunology
Xia M,Hu S,Fu Y,Jin W,Yi Q,Matsui Y,Yang J,McDowell MA,Sarkar S,Kalia V,Xiong N
25-0041 was used in Flow cytometry/Cell sorting to investigate the functional importance of CCR10/CCL27 in vivo, showing that CCR10 regulates maintenance and function of regulatory and effector T cells to promote immune homeostasis.
Mon Sep 01 00:00:00 EDT 2014
Lymph node stromal cells constrain immunity via MHC class II self-antigen presentation.
eLife
Baptista AP,Roozendaal R,Reijmers RM,Koning JJ,Unger WW,Greuter M,Keuning ED,Molenaar R,Goverse G,Sneeboer MM,den Haan JM,Boes M,Mebius RE
25-0041 was used in Flow cytometry/Cell sorting to investigate the role of MHC-II in lymph node stromal cells, showing that stromal cells constrain immunity through MHC-II expression.
Wed Nov 19 00:00:00 EST 2014
Regulatory T cells promote a protective Th17-associated immune response to intestinal bacterial infection with C. rodentium.
Mucosal immunology
Wang Z,Friedrich C,Hagemann SC,Korte WH,Goharani N,Cording S,Eberl G,Sparwasser T,Lochner M
25-0041 was used in Flow cytometry/Cell sorting to study the impact of Foxp3(+) Tregs on inflammatory processes elicited by the bacterial pathogen C. rodentium, showing that Tregs promote a protective Th17-associated immune response.
Sat Nov 01 00:00:00 EDT 2014
Parasite fate and involvement of infected cells in the induction of CD4+ and CD8+ T cell responses to Toxoplasma gondii.
PLoS pathogens
Dupont CD,Christian DA,Selleck EM,Pepper M,Leney-Greene M,Harms Pritchard G,Koshy AA,Wagage S,Reuter MA,Sibley LD,Betts MR,Hunter CA
25-0041 was used in Flow cytometry/Cell sorting to identify a critical role for actively infected host cells in initiating T. gondii-specific CD4+ and CD8+ T cell responses.
Tue Apr 01 00:00:00 EDT 2014
Exposure to cigarette smoke impacts myeloid-derived regulatory cell function and exacerbates airway hyper-responsiveness.
Laboratory investigation; a journal of technical methods and pathology
Wang Y,Jin TH,Farhana A,Freeman J,Estell K,Zmijewski JW,Gaggar A,Thannickal VJ,Schwiebert LM,Steyn AJ,Deshane JS
25-0041 was used in Flow cytometry/Cell sorting to assess the effects of exposing myeloid-derived regulatory cells to cigarette smoke on the production of nitric oxide.
Mon Dec 01 00:00:00 EST 2014
The transcription factor E74-like factor 4 suppresses differentiation of proliferating CD4+ T cells to the Th17 lineage.
Journal of immunology (Baltimore, Md. : 1950)
Lee PH,Puppi M,Schluns KS,Yu-Lee LY,Dong C,Lacorazza HD
25-0041 was used in Flow cytometry/Cell sorting to purified cells CD4+ T cells are inhibited from differentiating into Th17 cells by E74-like Factor 4.
Wed Jan 01 00:00:00 EST 2014
Differential requirement for CCR4 and CCR7 during the development of innate and adaptive αβT cells in the adult thymus.
Journal of immunology (Baltimore, Md. : 1950)
Cowan JE,McCarthy NI,Parnell SM,White AJ,Bacon A,Serge A,Irla M,Lane PJ,Jenkinson EJ,Jenkinson WE,Anderson G
25-0041 was used in Flow cytometry/Cell sorting to identify novel roles for CCR7 during intrathymic T cell development, highlighting its importance in enabling multiple αβT cell lineages to access the thymic medulla.
Fri Aug 01 00:00:00 EDT 2014
Immune stimulation following dermal exposure to unsintered indium tin oxide.
Journal of immunotoxicology
Brock K,Anderson SE,Lukomska E,Long C,Anderson K,Marshall N,Meade BJ
25-0041 was used in Flow cytometry/Cell sorting to elucidate the underlying causes of the development of several types of pulmonary pathology in workers in the indium industry.
Thu Apr 16 00:00:00 EDT 2015
The dichotomous pattern of IL-12r and IL-23R expression elucidates the role of IL-12 and IL-23 in inflammation.
PloS one
Chognard G,Bellemare L,Pelletier AN,Dominguez-Punaro MC,Beauchamp C,Guyon MJ,Charron G,Morin N,Sivanesan D,Kuchroo V,Xavier R,Michnick SW,Chemtob S,Rioux JD,Lesage S
25-0041 was used in Flow cytometry/Cell sorting to reveal an unforeseen lineage-specific dichotomy in the in vivo role of both the IL-12 and IL-23 pathways in pathological inflammatory states.
Fri Jan 02 00:00:00 EST 2015
Discriminating cellular heterogeneity using microwell-based RNA cytometry.
Nature communications
Dimov IK,Lu R,Lee EP,Seita J,Sahoo D,Park SM,Weissman IL,Lee LP
25-0041 was used in Flow cytometry/Cell sorting to develop a two-stage system to determine cellular heterogeneity.
Tue Mar 25 00:00:00 EDT 2014
Altered leukotriene B4 metabolism in CYP4F18-deficient mice does not impact inflammation following renal ischemia.
Biochimica et biophysica acta
Winslow V,Vaivoda R,Vasilyev A,Dombkowski D,Douaidy K,Stark C,Drake J,Guilliams E,Choudhary D,Preffer F,Stoilov I,Christmas P
25-0041 was used in Flow cytometry/Cell sorting to conclude that CYP4F18 is necessary for omega oxidation of leukotriene B4 in neutrophils, and is not compensated by other CYP enzymes.
Sun Jun 01 00:00:00 EDT 2014
Long-term prevention of chronic allograft rejection by regulatory T-cell immunotherapy involves host Foxp3-expressing T cells.
Blood
Pasquet L,Douet JY,Sparwasser T,Romagnoli P,van Meerwijk JP
25-0041 was used in Flow cytometry/Cell sorting to assess if persistence of administered regulatory T cells is required for long-term maintenance of tolerance to allografts.
Thu May 23 00:00:00 EDT 2013
The nucleotide sugar UDP-glucose mobilizes long-term repopulating primitive hematopoietic cells.
The Journal of clinical investigation
Kook S,Cho J,Lee SB,Lee BC
25-0041 was used in Flow cytometry/Cell sorting to demonstrate a novel mechanism governing the migration of haematopoietic stem progenitor cells under stress.
Thu Aug 01 00:00:00 EDT 2013
Medullary thymic epithelial cell depletion leads to autoimmune hepatitis.
The Journal of clinical investigation
Bonito AJ,Aloman C,Fiel MI,Danzl NM,Cha S,Weinstein EG,Jeong S,Choi Y,Walsh MC,Alexandropoulos K
25-0041 was used in Flow cytometry/Cell sorting to investigate the role of TRAF6 and medullary thymic epithelial cells (mETCs) in autoimmunity, showing that mETC depletion leads to autoimmune hepatitis.
Thu Aug 01 00:00:00 EDT 2013
The thymic medulla is required for Foxp3+ regulatory but not conventional CD4+ thymocyte development.
The Journal of experimental medicine
Cowan JE,Parnell SM,Nakamura K,Caamano JH,Lane PJ,Jenkinson EJ,Jenkinson WE,Anderson G
25-0041 was used in Flow cytometry/Cell sorting to demonstrate a differential requirement for the thymic medulla in relation to CD4 conventional and Foxp3(+) thymocyte lineages.
Mon Apr 08 00:00:00 EDT 2013
Mesenchymal stem cells are mobilized from the bone marrow during inflammation.
Frontiers in immunology
Koning JJ,Kooij G,de Vries HE,Nolte MA,Mebius RE
25-0041 was used in Flow cytometry/Cell sorting to analyse mesenchymal stem- and T-cell migration during experimental allergic encephalomyelitis.
Wed Mar 06 00:00:00 EST 2013
Atheroprotective Vaccination with MHC-II Restricted Peptides from ApoB-100.
Frontiers in immunology
Tse K,Gonen A,Sidney J,Ouyang H,Witztum JL,Sette A,Tse H,Ley K
25-0041 was used in Flow cytometry/Cell sorting to investigate antigen specificity of T-cells induced by vaccination with low-density lipoprotein or oxidised low-density lipoprotein, and the mechanism of protection.
Mon Jan 13 00:00:00 EST 2014
Th17-cell plasticity in Helicobacter hepaticus-induced intestinal inflammation.
Mucosal immunology
Morrison PJ,Bending D,Fouser LA,Wright JF,Stockinger B,Cooke A,Kullberg MC
25-0041 was used in Flow cytometry/Cell sorting to uncover the immunoinflammatory contribution of Th1 and Th17 T cell subsets during murine Helicobacter hepaticus-induced typhlocolitis.
Fri Nov 01 00:00:00 EDT 2013
Colonic patch and colonic SILT development are independent and differentially regulated events.
Mucosal immunology
Baptista AP,Olivier BJ,Goverse G,Greuter M,Knippenberg M,Kusser K,Domingues RG,Veiga-Fernandes H,Luster AD,Lugering A,Randall TD,Cupedo T,Mebius RE
25-0041 was used in Immunofluorescence to distinguish the different mechanisms responsible for the formation of two distinct colonic lymphoid tissues.
Wed May 01 00:00:00 EDT 2013
Therapeutic evaluation of ex vivo-generated versus natural regulatory T-cells in a mouse model of chronic gut inflammation.
Inflammatory bowel diseases
Karlsson F,Martinez NE,Gray L,Zhang S,Tsunoda I,Grisham MB
25-0041 was used in Flow cytometry/Cell sorting to study the effect of ex vivo-generated and isolated Treg cells on a mouse model of chronic colitis, showing that ex-vivo Tregs were more potent at attenuating colitis, likely due to the associated decrease in IL-6 and IL-17A expression in the colon.
Tue Oct 01 00:00:00 EDT 2013
Generation of both cortical and Aire(+) medullary thymic epithelial compartments from CD205(+) progenitors.
European journal of immunology
Baik S,Jenkinson EJ,Lane PJ,Anderson G,Jenkinson WE
25-0041 was used in Flow cytometry/Cell sorting to reveal an unexpected overlap in the phenotypic properties of bipotent TECs with their lineage-restricted counterparts.
Fri Mar 01 00:00:00 EST 2013
Parental dietary fat intake alters offspring microbiome and immunity.
Journal of immunology (Baltimore, Md. : 1950)
Myles IA,Fontecilla NM,Janelsins BM,Vithayathil PJ,Segre JA,Datta SK
25-0041 was used in Flow cytometry/Cell sorting to reveal that parental fat consumption can leave a "lard legacy", impacting offspring immunity and health.
Sun Sep 15 00:00:00 EDT 2013
Reduced CD18 levels drive regulatory T cell conversion into Th17 cells in the CD18hypo PL/J mouse model of psoriasis.
Journal of immunology (Baltimore, Md. : 1950)
Singh K,Gatzka M,Peters T,Borkner L,Hainzl A,Wang H,Sindrilaru A,Scharffetter-Kochanek K
25-0041 was used in Flow cytometry/Cell sorting to investigate the influence of adhesion molecules on the differentiation of Foxp3(+) Tregs into proinflammatory Th17 cells occurring in lesional skin and blood of psoriasis patients.
Fri Mar 15 00:00:00 EDT 2013
Hepatic stellate cells preferentially induce Foxp3+ regulatory T cells by production of retinoic acid.
Journal of immunology (Baltimore, Md. : 1950)
Dunham RM,Thapa M,Velazquez VM,Elrod EJ,Denning TL,Pulendran B,Grakoui A
25-0041 was used in Flow cytometry/Cell sorting to demonstrate a potential Treg enrichment role for hepatic stellate cells, supporting the tolerogenic nature of the liver.
Fri Mar 01 00:00:00 EST 2013
Systems modeling of molecular mechanisms controlling cytokine-driven CD4+ T cell differentiation and phenotype plasticity.
PLoS computational biology
Carbo A,Hontecillas R,Kronsteiner B,Viladomiu M,Pedragosa M,Lu P,Philipson CW,Hoops S,Marathe M,Eubank S,Bisset K,Wendelsdorf K,Jarrah A,Mei Y,Bassaganya-Riera J
25-0041 was used in Flow cytometry/Cell sorting to investigate the mechanisms controlling differentiation and plasticity of CD4+ T cells in the gut of mice.
Mon Apr 01 00:00:00 EDT 2013
Ontogeny and localization of the cells produce IL-2 in healthy animals.
Cytokine
Yamamoto M,Seki Y,Iwai K,Ko I,Martin A,Tsuji N,Miyagawa S,Love RB,Iwashima M
25-0041 was used in Flow cytometry/Cell sorting to study how a group of Tr1 cells may have additional roles in immune homeostasis through IL-2 production to aid in the maintenance of other regulatory T cells..
Fri Mar 01 00:00:00 EST 2013
Predictive computational modeling of the mucosal immune responses during Helicobacter pylori infection.
PloS one
Carbo A,Bassaganya-Riera J,Pedragosa M,Viladomiu M,Marathe M,Eubank S,Wendelsdorf K,Bisset K,Hoops S,Deng X,Alam M,Kronsteiner B,Mei Y,Hontecillas R
25-0041 was used in Flow cytometry/Cell sorting to investigate how CD4+ T-cells and other immune cell subsets are distributed in the gut mucosa during Helicobacter pylori infection.
Sat Jun 07 00:00:00 EDT 2014
Ectopic Runx1 expression rescues Tal-1-deficiency in the generation of primitive and definitive hematopoiesis.
PloS one
Tornack J,Seiler K,Grützkau A,Grün JR,Onodera M,Melchers F,Tsuneto M
25-0041 was used in Flow cytometry/Cell sorting to suggest that Tal-1 expression is needed to express Runx1 in the mesoderm.
Thu Aug 21 00:00:00 EDT 2014
Two-photon microscopy imaging of thy1GFP-M transgenic mice: a novel animal model to investigate brain dendritic cell subsets in vivo.
PloS one
Laperchia C,Allegra Mascaro AL,Sacconi L,Andrioli A,Mattè A,De Franceschi L,Grassi-Zucconi G,Bentivoglio M,Buffelli M,Pavone FS
25-0041 was used in Flow cytometry/Cell sorting to employ a transgenic mouse model to study professional antigen-presenting cells in the brain.
Mon Jul 29 00:00:00 EDT 2013
IFNγ induces monopoiesis and inhibits neutrophil development during inflammation.
Blood
de Bruin AM,Libregts SF,Valkhof M,Boon L,Touw IP,Nolte MA
25-0041 was used in Flow cytometry/Cell sorting to demonstrate that the pro-inflammatory cytokine IFNγ is involved in orchestrating inflammation-induced myelopoiesis.
Thu Feb 09 00:00:00 EST 2012
Thymus-autonomous T cell development in the absence of progenitor import.
The Journal of experimental medicine
Martins VC,Ruggiero E,Schlenner SM,Madan V,Schmidt M,Fink PJ,von Kalle C,Rodewald HR
25-0041 was used in Flow cytometry/Cell sorting to characterise the previously unrecognised capacity of the thymus to sustain T cell development during bone marrow progenitor deprivation.
Mon Jul 30 00:00:00 EDT 2012
IL-33 induces innate lymphoid cell-mediated airway inflammation by activating mammalian target of rapamycin.
The Journal of allergy and clinical immunology
Salmond RJ,Mirchandani AS,Besnard AG,Bain CC,Thomson NC,Liew FY
25-0041 was used in Flow cytometry/Cell sorting to investigate the role of mTOR signalling in the activation of TH2, ILC and IL-33 inflammation responses.
Thu Nov 01 00:00:00 EDT 2012
Neonatal rhinovirus infection induces mucous metaplasia and airways hyperresponsiveness.
Journal of immunology (Baltimore, Md. : 1950)
Schneider D,Hong JY,Popova AP,Bowman ER,Linn MJ,McLean AM,Zhao Y,Sonstein J,Bentley JK,Weinberg JB,Lukacs NW,Curtis JL,Sajjan US,Hershenson MB
25-0041 was used in Flow cytometry/Cell sorting to conclude that neonatal RV1B infection leads to persistent airway inflammation, in part mediated by IL-13.
Thu Mar 15 00:00:00 EDT 2012
Developmentally regulated availability of RANKL and CD40 ligand reveals distinct mechanisms of fetal and adult cross-talk in the thymus medulla.
Journal of immunology (Baltimore, Md. : 1950)
Desanti GE,Cowan JE,Baik S,Parnell SM,White AJ,Penninger JM,Lane PJ,Jenkinson EJ,Jenkinson WE,Anderson G
25-0041 was used in Flow cytometry/Cell sorting to study how multiple hemopoietic cell types regulate mTEC development through differential provision of RANKL/CD40L during ontogeny, revealing molecular differences in foetal and adult hemopoietic cross-talk.
Sat Dec 15 00:00:00 EST 2012
Intratumoral hu14.18-IL-2 (IC) induces local and systemic antitumor effects that involve both activated T and NK cells as well as enhanced IC retention.
Journal of immunology (Baltimore, Md. : 1950)
Yang RK,Kalogriopoulos NA,Rakhmilevich AL,Ranheim EA,Seo S,Kim K,Alderson KL,Gan J,Reisfeld RA,Gillies SD,Hank JA,Sondel PM
25-0041 was used in Flow cytometry/Cell sorting to study how IT-IC resulted in increased numbers of activated T and NK cells within tumours, better IC retention in the tumour, enhanced inhibition of tumour growth, and improved survival compared with i.v.-IC.
Sat Sep 01 00:00:00 EDT 2012
Requirement for diverse TCR specificities determines regulatory T cell activity in a mouse model of autoimmune arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Oh S,Aitken M,Simons DM,Basehoar A,Garcia V,Kropf E,Caton AJ
25-0041 was used in Flow cytometry/Cell sorting to investigate why CD4(+)CD25(+)Foxp3(+) Tregs allow organ-specific autoimmunity, showing that polyclonal Tregs suppressed Th17 cell formation and prevented arthritis development, but clonotypic Tregs did not, indicating that diverse TCR specificities are required.
Tue May 01 00:00:00 EDT 2012
Epigenetic alterations may regulate temporary reversal of CD4(+) T cell activation caused by trichloroethylene exposure.
Toxicological sciences : an official journal of the Society of Toxicology
Gilbert KM,Nelson AR,Cooney CA,Reisfeld B,Blossom SJ
25-0041 was used in Flow cytometry/Cell sorting to investigate the epigenetic effects of trichloroethylene exposure on the activation state of CD4+ T cells.
Tue May 01 00:00:00 EDT 2012
Impact of intravenous immunoglobulin on the dopaminergic system and immune response in the acute MPTP mouse model of Parkinson's disease.
Journal of neuroinflammation
St-Amour I,Bousquet M,Paré I,Drouin-Ouellet J,Cicchetti F,Bazin R,Calon F
25-0041 was used in Flow cytometry/Cell sorting to investigate the potential neurorestorative effect of IVIg treatment in mice.
Tue Oct 09 00:00:00 EDT 2012
Proteomic cornerstones of hematopoietic stem cell differentiation: distinct signatures of multipotent progenitors and myeloid committed cells.
Molecular & cellular proteomics : MCP
Klimmeck D,Hansson J,Raffel S,Vakhrushev SY,Trumpp A,Krijgsveld J
25-0041 was used in Flow cytometry/Cell sorting to discern the distinct signatures of multipotent progenitors and myeloid committed cells.
Wed Aug 01 00:00:00 EDT 2012
Optimal isolation of functional Foxp3+ induced regulatory T cells using DEREG mice.
PloS one
Baru AM,Untucht C,Ganesh V,Hesse C,Mayer CT,Sparwasser T
25-0041 was used in Flow cytometry/Cell sorting to define culture conditions for efficient generation of eGFP(+)Foxp3(+) iTregs by use of DEREG mice.
Thu Feb 14 00:00:00 EST 2013
Absence of β2 integrins impairs regulatory T cells and exacerbates CD4+ T cell-dependent autoimmune carditis.
Journal of immunology (Baltimore, Md. : 1950)
Haasken S,Auger JL,Binstadt BA
25-0041-82 was used in Functional assays to investigate the contribution of CD4(+) T cells and β(2) integrins in the pathogenesis of autoimmune arthritis and endocarditis.
Thu Sep 01 00:00:00 EDT 2011
Angiopoietin 2 stimulates TIE2-expressing monocytes to suppress T cell activation and to promote regulatory T cell expansion.
Journal of immunology (Baltimore, Md. : 1950)
Coffelt SB,Chen YY,Muthana M,Welford AF,Tal AO,Scholz A,Plate KH,Reiss Y,Murdoch C,De Palma M,Lewis CE
25-0041 was used in Flow cytometry/Cell sorting to suggest that ANGPT2-stimulated TIE2-expressing monocytes/macrophages represent a novel, potent immunosuppressive force in tumours.
Fri Apr 01 00:00:00 EDT 2011
Restricted microbiota and absence of cognate TCR antigen leads to an unbalanced generation of Th17 cells.
Journal of immunology (Baltimore, Md. : 1950)
Lochner M,Bérard M,Sawa S,Hauer S,Gaboriau-Routhiau V,Fernandez TD,Snel J,Bousso P,Cerf-Bensussan N,Eberl G
25-0041 was used in Flow cytometry/Cell sorting to demonstrate that a complex microbiota and cognate antigen are required to generate a properly regulated set of Foxp3+RORγt+ T cells and Th17 cells.
Tue Feb 01 00:00:00 EST 2011
Clonal analysis reveals uniformity in the molecular profile and lineage potential of CCR9(+) and CCR9(-) thymus-settling progenitors.
Journal of immunology (Baltimore, Md. : 1950)
Desanti GE,Jenkinson WE,Parnell SM,Boudil A,Gautreau-Rolland L,Eksteen B,Ezine S,Lane PJ,Jenkinson EJ,Anderson G
25-0041 was used in Flow cytometry/Cell sorting to suggest that the earliest T cell progenitors represent a developmentally homogeneous progenitor pool that ensures the efficient generation of the first cohorts of T cells during thymus development.
Sun May 01 00:00:00 EDT 2011
Genetic variation determines mast cell functions in experimental asthma.
Journal of immunology (Baltimore, Md. : 1950)
Becker M,Reuter S,Friedrich P,Doener F,Michel A,Bopp T,Klein M,Schmitt E,Schild H,Radsak MP,Echtenacher B,Taube C,Stassen M
25-0041 was used in Flow cytometry/Cell sorting to investigate the role of mast cells in allergic asthma.
Wed Jun 15 00:00:00 EDT 2011
Cationic lipid/DNA complex-adjuvanted influenza A virus vaccination induces robust cross-protective immunity.
Journal of virology
Hong DK,Chang S,Botham CM,Giffon TD,Fairman J,Lewis DB
25-0041 was used in Flow cytometry/Cell sorting to demonstrate that CLDC-adjuvanted vaccination provides significant cross-protection from influenza A viral challenge.
Wed Dec 01 00:00:00 EST 2010
Expanded CD23(+)/CD21(hi) B cells in inflamed lymph nodes are associated with the onset of inflammatory-erosive arthritis in TNF-transgenic mice and are targets of anti-CD20 therapy.
Journal of immunology (Baltimore, Md. : 1950)
Li J,Kuzin I,Moshkani S,Proulx ST,Xing L,Skrombolas D,Dunn R,Sanz I,Schwarz EM,Bottaro A
25-0041 was used in Flow cytometry/Cell sorting to investigate the pathogenic role of B lymphocytes in rheumatoid arthritis, showing that CD23(+)/CD21(hi) B cells in inflamed lymph nodes are associated with the onset of inflammatory-erosive arthritis.
Tue Jun 01 00:00:00 EDT 2010
Dendritic cells continue to capture and present antigens after maturation in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Drutman SB,Trombetta ES
25-0041 was used in Flow cytometry/Cell sorting to study the dynamics of Ag capture and presentation in situ, showing that dendritic cells continue to capture and present antigens after maturation.
Sun Aug 15 00:00:00 EDT 2010
Antigen-specific immunity and cross-priming by epithelial ovarian carcinoma-induced CD11b(+)Gr-1(+) cells.
Journal of immunology (Baltimore, Md. : 1950)
Tomihara K,Guo M,Shin T,Sun X,Ludwig SM,Brumlik MJ,Zhang B,Curiel TJ,Shin T
25-0041 was used in Flow cytometry/Cell sorting to investigate CD11b(+)Gr-1(+) cells found in epithelial ovarian cancer-bearing mice, which are induced by ovarian cancer cells and undergo antigen-specific immunity and cross-priming.
Tue Jun 01 00:00:00 EDT 2010
The innate immune response to uropathogenic Escherichia coli involves IL-17A in a murine model of urinary tract infection.
Journal of immunology (Baltimore, Md. : 1950)
Sivick KE,Schaller MA,Smith SN,Mobley HL
25-0041 was used in Flow cytometry/Cell sorting to show that IL-17A is a key mediator for the innate immune response to UTIs.
Mon Feb 15 00:00:00 EST 2010
Additive and global functions of HoxA cluster genes in mesoderm derivatives.
Developmental biology
Di-Poï N,Koch U,Radtke F,Duboule D
25-0041 was used in Flow cytometry/Cell sorting to report that mutant mice lacking the entire HoxA cluster in mesodermal lineages display the expected spectrum of postnatal respiratory, cardiac and urogenital defects, previously reported for single gene mutations.
Sat May 15 00:00:00 EDT 2010
Late developmental plasticity in the T helper 17 lineage.
Immunity
Lee YK,Turner H,Maynard CL,Oliver JR,Chen D,Elson CO,Weaver CT
25-0041 was used in Flow cytometry/Cell sorting to investigate a model of late Th17 developmental plasticity with implications for autoimmunity and host defense.
Fri Jan 16 00:00:00 EST 2009
Contrasting roles for all-trans retinoic acid in TGF-beta-mediated induction of Foxp3 and Il10 genes in developing regulatory T cells.
The Journal of experimental medicine
Maynard CL,Hatton RD,Helms WS,Oliver JR,Stephensen CB,Weaver CT
25-0041 was used in Flow cytometry/Cell sorting to investigate alternative roles for all-trans retinoic acid in developing regulatory T cells.
Mon Feb 16 00:00:00 EST 2009
Multiplexed labeling of samples with cell tracking dyes facilitates rapid and accurate internally controlled calcium flux measurement by flow cytometry.
Journal of immunological methods
Fu G,Gascoigne NR
25-0041 was used in Flow cytometry/Cell sorting to present an improved method to measure calcium flux that allows different lymphocyte populations to be tested in the same sample.
Sat Oct 31 00:00:00 EDT 2009
Vaccine adjuvants alter TCR-based selection thresholds.
Immunity
Malherbe L,Mark L,Fazilleau N,McHeyzer-Williams LJ,McHeyzer-Williams MG
25-0041 was used in Flow cytometry/Cell sorting to demonstrate the capacity of adjuvants to modify antigen-specific helper T cell clonal composition.
Thu May 01 00:00:00 EDT 2008
Effector memory CD4+ T cells mediate graft-versus-leukemia without inducing graft-versus-host disease.
Blood
Zheng H,Matte-Martone C,Li H,Anderson BE,Venketesan S,Sheng Tan H,Jain D,McNiff J,Shlomchik WD
25-0041 was used in Flow cytometry/Cell sorting to investigate the role of unprimed T cells in graft-versus-leukemia.
Fri Feb 15 00:00:00 EST 2008
In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells.
The Journal of experimental medicine
Lochner M,Peduto L,Cherrier M,Sawa S,Langa F,Varona R,Riethmacher D,Si-Tahar M,Di Santo JP,Eberl G
25-0041 was used in Flow cytometry/Cell sorting to study how potentially antagonistic pro-inflammatory IL-17-producing and regulatory Foxp3(+) RORgamma t(+) T cells coexist and are tightly controlled.
Mon Jun 09 00:00:00 EDT 2008
TRAIL deficiency does not rescue impaired CD8+ T cell memory generated in the absence of CD4+ T cell help.
Journal of immunology (Baltimore, Md. : 1950)
Sacks JA,Bevan MJ
25-0041 was used in Flow cytometry/Cell sorting to investigate the role of the proapoptotic molecule TRAIL in unhelped CD8(+) T cells.
Tue Apr 01 00:00:00 EDT 2008
Suppression of alkali burn-induced corneal neovascularization by dendritic cell vaccination targeting VEGF receptor 2.
Investigative ophthalmology & visual science
Mochimaru H,Usui T,Yaguchi T,Nagahama Y,Hasegawa G,Usui Y,Shimmura S,Tsubota K,Amano S,Kawakami Y,Ishida S
Thu May 01 00:00:00 EDT 2008
Phenotypic switching in Cryptococcus neoformans contributes to virulence by changing the immunological host response.
Infection and immunity
Guerrero A,Fries BC
25-0041 was used in Flow cytometry/Cell sorting to compare survival rates and characterise the host responses of C. neoformans-resistant mice.
Mon Sep 01 00:00:00 EDT 2008
Myocardial infarct-sparing effect of adenosine A2A receptor activation is due to its action on CD4+ T lymphocytes.
Circulation
Yang Z,Day YJ,Toufektsian MC,Xu Y,Ramos SI,Marshall MA,French BA,Linden J
Tue Nov 07 00:00:00 EST 2006
An MHC-linked locus modulates thymic differentiation of CD4+CD25+Foxp3+ regulatory T lymphocytes.
International immunology
Tellier J,van Meerwijk JP,Romagnoli P
25-0041 was used in Flow cytometry/Cell sorting to investigate factors that affect the levels of Tregs in the thymus.
Wed Nov 01 00:00:00 EST 2006
