What are electrophilic aromatic substitution (EAS) reactions?
The electrophilic aromatic substitution (EAS) is a chemical reaction in which an atom attached to an aromatic system is replaced by an electrophile. Within the category of EAS reactions, there are a number of important chemical reactions which are named after their discoverers. Despite being discovered many years ago, these named reactions continue to play a crucial role in organic synthesis, and in constructing ever more complex and diverse chemical molecules.
One of the earliest and perhaps best-known categories of these named reactions is the Friedel-Crafts Acylation and Alkylation Reactions. These are also related to several other classic named reactions in this category.
Learn more about these EAS reactions:
In addition, there are a number of other key named EAS reactions:
- Pictet-Spengler Tetrahydroisoquinoline Synthesis
- Pomeranz-Fritsch Reaction
- Bischler-Napieralski Synthesis
- Combes Synthesis
- Kolbe-Schmitt Reaction
- Reimer-Tiemann Reaction
- Vilsmeier-Haack Formylation
- Von Pechmann Reaction
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