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Achieve your scientific and business goals for clinical research and toxicology with our extensive, robust, and reliable portfolio of chromatography and mass spectrometry products. From biomarker assays using immunoaffinity enrichment to GC-MS for volatile analysis, and LC-MS for non-volatile compounds, Thermo Fisher Scientific offers an optimal combination of instrumentation, sample preparation, and consumable solutions for endocrinology, clinical translational research, drugs of abuse analysis and therapeutic drug research.
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Triple quadrupole MS systems for clinical research & toxicology
Achieve ultimate confidence in your clinical research and toxicology data with our portfolio of triple quadrupoles. Innovations in the ion source, mass analyzer and RF electronics offer high sensitivity, reduced noise, and more data points with high SRM rates. You can confidently quantify compounds at extremely low concentrations, in the most challenging matrices.
 TSQ Altis Triple Quadrupole Mass Spectrometer |  TSQ Quantis Triple Quadrupole Mass Spectrometer |  TSQ Fortis Triple Quadrupole Mass Spectrometer |
|---|---|---|
| Ultimate sensitivity and selectivity to meet tomorrow's standards today | Everyday quantitation workhorse to meet today's standards | Quality data across workflows for users at all expertise levels |
High resolution, accurate mass Orbitrap Exploris mass spectrometers
Leverage the high resolution, accuracy, and sensitivity of Thermo Scientific Orbitrap mass analyzer technology to address critical challenges faced in quantitation of proteins in complex biological matrices and accelerate your clinical research, translating your qualitative and quantitative assays into future clinical research applications.
 Orbitrap Exploris 120 Mass Spectrometer |  Orbitrap Exploris 240 Mass Spectrometer |  Orbitrap Exploris 480 Mass Spectrometer |
|---|---|---|
| Consistent, accurate data, operational simplicity, instrument ruggedness for method development and everyday testing | Precision and accuracy to drive discovery, scale up and make an impact, with application versatility and operational simplicity | Next-level insights, exploratory and targeted quantitation, next-generation power, performance and ease of use |
Need more help choosing an instrument?
Visit one of the pages below to learn more about the capabilities of our products.
HPLC systems and columns for clinical research & toxicology
Our liquid chromatography (LC) systems feature high sample capacity for high-throughput workflows, industry-leading pumping performance, high S/N and linearity. Our extensive portfolio of HPLC and UHPLC systems can be tailored to provide the best chromatographic resolution for your clinical research assays. We offer binary or quaternary and multichannel systems with a variety of columns, detectors and autosamplers.
 Vanquish Horizon |  Transcend Multichannel Systems |  Vanquish Neo UHPLC System | |
|---|---|---|---|
| Flow Range (settable) | 0.001–5 mL/min, in 1 µL/min increments | 0.001–5 mL/min, in 1 µL/min increments | 1 nL/min – 100 μL/min, in 1 nL increments (100 nL/min – 100 μL/min, recommended) |
| Pressure Range | 50–1517 bar | 50–1517 bar | 1500 bar, maximum |
HPLC Columns for clinical research & toxicology
Thermo Scientific HPLC Columns are designed to meet a variety of clinical research and toxicology analysis challenges regardless of matrix or analyte.
Technical notes
Sample preparation for clinical research & toxicology
Our sample preparation products help you get the most accurate results from your LC-MS and GC-MS analyses.
| Analyte | Sample preparation product | Related resource |
|---|---|---|
| Drugs of abuse | SOLAµ SPE Plates | Drugs of abuse in human plasma using SOLAµ solid phase extraction |
| Clinical research small molecules | TurboFlow technology | Quantification of thirty-one antidepressants in human serum by TurboFlow chromatography coupled to high-resolution Orbitrap mass spectrometry for clinical research |
| Monoclonal antibodies | SMART Digest Trypsin Kits | Comparison of alternative approaches to trypsin protein digestion for reproducible and efficient peptide mapping analysis of monoclonal antibodies |
Application note
GC-MS systems and columns for clinical research & toxicology
When analytes of interest for clinical research or toxicology are too polar to be retained in an LC separation, or cannot be ionized using electrospray, gas chromatography-mass spectrometry (GC-MS) systems are available for your screening or quantitation assays.
Offers the quantitative power of a GC triple quadrupole MS combined with high-precision, full scan HR/AM capabilities.
- Mass range: 50 to 3,000 m/z
- Detection limit <6 fg OFN
- Quantitative dynamic range: > 106
- Resolving power up to 100,000 at m/z 272
- Part-per-trillion-level sensitivity
Designed for and developed with high throughput analytical labs to deliver the highest productivity, with MS/MS simplicity and even higher performance SRM.
- Mass range: 1.2 to 1100 u
- Detection limit ≤ 0.4 fg OFN depending on configuration
- Scan up to 20,000 u/s
- Up to 800 SRM transitions
Gas chromatography columns for clinical research & toxicology
Thermo Scientific GC Columns meet a variety of clinical research and toxicology analysis challenges including monitoring drugs of abuse and blood alcohol levels and performing antidoping analyses.
| Application | GC Column |
|---|---|
| Drugs of Abuse | TRACE GC Columns for Drugs of Abuse |
| Blood Alcohol | TraceGOLD TG-ALC Plus II GC Columns |
| Antidoping |
IC-MS systems for clinical research & toxicology
For trace level analysis, our portfolio of ion chromatography systems can be paired with mass spectrometers to provide high resolution, sensitivity, and throughput for even the most complex assays.
We offer a wide variety of chemistries, detectors, and automation options to fit your clinical research and toxicology needs.
Dionex ICS-6000 Hybrid HPIC System
The Thermo Scientific Dionex ICS-6000 HPIC system enables direct injection with no derivatization and precludes use of organic modifiers in separations.
- Pressure Range 0 to 35 mPa
- Flow Rate 0.01 – 10 mL/min
- Eluent Types: KOH, LiOH, NaOH; Carbonate; Carbonate/Bicarbonate; MSA
ICP-MS systems for clinical research & toxicology
Thermo Scientific ICP-MS platforms enable easy, efficient detection of trace elements in clinical samples.
Whether you perform routine total elemental analyses or state of the art research, this unique system delivers powerful, highly sensitive trace detection, fast. With three models available, the iCAP RQplus ICP-MS is the ideal tool for a wide range of applications and market sectors, from routine 24/7 analysis to demanding high quality research.
Increase sample throughput in your laboratory with Thermo Scientific CETAC Autosamplers.
- CETAC ASX-280 Autosampler offers a 180 sample capacity for low-moderate sample throughput
- CETAC ASX-560 Autosampler accommodates up to 360 samples for moderate-high sample throughput
HPLC systems and columns for clinical research & toxicology
Our liquid chromatography (LC) systems feature high sample capacity for high-throughput workflows, industry-leading pumping performance, high S/N and linearity. Our extensive portfolio of HPLC and UHPLC systems can be tailored to provide the best chromatographic resolution for your clinical research assays. We offer binary or quaternary and multichannel systems with a variety of columns, detectors and autosamplers.
Vanquish Horizon | Transcend Multichannel Systems | Vanquish Neo UHPLC System | |
|---|---|---|---|
| Flow Range (settable) | 0.001–5 mL/min, in 1 µL/min increments | 0.001–5 mL/min, in 1 µL/min increments | 1 nL/min – 100 μL/min, in 1 nL increments (100 nL/min – 100 μL/min, recommended) |
| Pressure Range | 50–1517 bar | 50–1517 bar | 1500 bar, maximum |
HPLC Columns for clinical research & toxicology
Thermo Scientific HPLC Columns are designed to meet a variety of clinical research and toxicology analysis challenges regardless of matrix or analyte.
Technical notes
Sample preparation for clinical research & toxicology
Our sample preparation products help you get the most accurate results from your LC-MS and GC-MS analyses.
| Analyte | Sample preparation product | Related resource |
|---|---|---|
| Drugs of abuse | SOLAµ SPE Plates | Drugs of abuse in human plasma using SOLAµ solid phase extraction |
| Clinical research small molecules | TurboFlow technology | Quantification of thirty-one antidepressants in human serum by TurboFlow chromatography coupled to high-resolution Orbitrap mass spectrometry for clinical research |
| Monoclonal antibodies | SMART Digest Trypsin Kits | Comparison of alternative approaches to trypsin protein digestion for reproducible and efficient peptide mapping analysis of monoclonal antibodies |
Application note
GC-MS systems and columns for clinical research & toxicology
When analytes of interest for clinical research or toxicology are too polar to be retained in an LC separation, or cannot be ionized using electrospray, gas chromatography-mass spectrometry (GC-MS) systems are available for your screening or quantitation assays.
Offers the quantitative power of a GC triple quadrupole MS combined with high-precision, full scan HR/AM capabilities.
- Mass range: 50 to 3,000 m/z
- Detection limit <6 fg OFN
- Quantitative dynamic range: > 106
- Resolving power up to 100,000 at m/z 272
- Part-per-trillion-level sensitivity
Designed for and developed with high throughput analytical labs to deliver the highest productivity, with MS/MS simplicity and even higher performance SRM.
- Mass range: 1.2 to 1100 u
- Detection limit ≤ 0.4 fg OFN depending on configuration
- Scan up to 20,000 u/s
- Up to 800 SRM transitions
Gas chromatography columns for clinical research & toxicology
Thermo Scientific GC Columns meet a variety of clinical research and toxicology analysis challenges including monitoring drugs of abuse and blood alcohol levels and performing antidoping analyses.
| Application | GC Column |
|---|---|
| Drugs of Abuse | TRACE GC Columns for Drugs of Abuse |
| Blood Alcohol | TraceGOLD TG-ALC Plus II GC Columns |
| Antidoping |
IC-MS systems for clinical research & toxicology
For trace level analysis, our portfolio of ion chromatography systems can be paired with mass spectrometers to provide high resolution, sensitivity, and throughput for even the most complex assays.
We offer a wide variety of chemistries, detectors, and automation options to fit your clinical research and toxicology needs.
Dionex ICS-6000 Hybrid HPIC System
The Thermo Scientific Dionex ICS-6000 HPIC system enables direct injection with no derivatization and precludes use of organic modifiers in separations.
- Pressure Range 0 to 35 mPa
- Flow Rate 0.01 – 10 mL/min
- Eluent Types: KOH, LiOH, NaOH; Carbonate; Carbonate/Bicarbonate; MSA
ICP-MS systems for clinical research & toxicology
Thermo Scientific ICP-MS platforms enable easy, efficient detection of trace elements in clinical samples.
Whether you perform routine total elemental analyses or state of the art research, this unique system delivers powerful, highly sensitive trace detection, fast. With three models available, the iCAP RQplus ICP-MS is the ideal tool for a wide range of applications and market sectors, from routine 24/7 analysis to demanding high quality research.
Increase sample throughput in your laboratory with Thermo Scientific CETAC Autosamplers.
- CETAC ASX-280 Autosampler offers a 180 sample capacity for low-moderate sample throughput
- CETAC ASX-560 Autosampler accommodates up to 360 samples for moderate-high sample throughput
Peer-Reviewed Publications
Visit our library of peer-reviewed journal publications to learn more about the work researchers are doing using Thermo Scientific technologies in the fields of:
- Toxicology
- Translational research
- Clinical biomarkers
- Endocrinology
- Therapeutic drug monitoring
- Orthogonal techniques
Resources
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