Volume Electron Microscopy

Understanding of function of intracellular organelles, compartments, and other structures often requires the visualization and quantification of their organization and interactions in 3D space.  Volume electron microscopy or volume EM (vEM) was named one of Nature’s Technologies to Watch in 2023.  The emerging field of volume EM refers to a variety of imaging approaches and processing techniques that uses electron microscopy to explore below the surface of cellular ultrastructure, tissue, and small model organisms in 3D, at micron to millimeter volume scales, at nanometer-level resolutions, and even at native state under cryogenic conditions.
 

Our volume EM solutions allow you to observe how tissues, cells, and organelles respond to diseases or various experimental methods. Our volume EM microscopes offer integrated solutions for correlative light and electron microscopy, multiple plasma ion-sources, large area automated serial fib SEM milling (up to 1 mm with Spin Mill), and room temperature and cryogenic operation. When combined with cryo-electron microscopy (cryo-EM) or cryo-electron tomography (cryo-ET), volume EM enables direct observation of molecular interactions in the cellular ultrastructure.