Product References
Tau protein binds to the P53 E3 ubiquitin ligase MDM2.
Scientific reports
Sola M,Rendon-Angel A,Rojo Martinez V,Sgrignani J,Magrin C,Piovesana E,Cavalli A,Paganetti P,Papin S
MN1000B was used in AlphaLISA to report the existence in cells and brain of a Tau-MDM2 complex that, in vitro, exhibits reduced P53 ubiquitination activity in a manner sensitive to a Tau mutation.
Fri Jun 23 00:00:00 EDT 2023
Glymphatic system clears extracellular tau and protects from tau aggregation and neurodegeneration.
The Journal of experimental medicine
Ishida K,Yamada K,Nishiyama R,Hashimoto T,Nishida I,Abe Y,Yasui M,Iwatsubo T
MN1000B was used in ELISA to study the mechanisms facilitating the elimination of extracellular tau from the brain to CSF and subsequently to deep cervical lymph node, in the Glymphatic clearance system.
Mon Mar 07 00:00:00 EST 2022
Glymphatic system clears extracellular tau and protects from tau aggregation and neurodegeneration.
The Journal of experimental medicine
Ishida K,Yamada K,Nishiyama R,Hashimoto T,Nishida I,Abe Y,Yasui M,Iwatsubo T
MN1000B was used in ELISA to study the mechanisms facilitating the elimination of extracellular tau from the brain to CSF and subsequently to deep cervical lymph node, in the Glymphatic clearance system.
Mon Mar 07 00:00:00 EST 2022
Elongator promotes neuritogenesis via regulation of tau stability through acly activity.
Frontiers in cell and developmental biology
Shilian M,Even A,Gast H,Nguyen L,Weil M
Published figure using Tau monoclonal antibody (Product # MN1000B) in Immunoprecipitation
Sat Nov 19 00:00:00 EST 2022
Elongator promotes neuritogenesis via regulation of tau stability through acly activity.
Frontiers in cell and developmental biology
Shilian M,Even A,Gast H,Nguyen L,Weil M
Published figure using Tau monoclonal antibody (Product # MN1000B) in Immunoprecipitation
Sat Nov 19 00:00:00 EST 2022
O-GlcNAcase Inhibitor ASN90 is a Multimodal Drug Candidate for Tau and α-Synuclein Proteinopathies.
ACS chemical neuroscience
Permanne B,Sand A,Ousson S,Nény M,Hantson J,Schubert R,Wiessner C,Quattropani A,Beher D
MN1000B was used in Inhibition Assays to provide a strong rationale for the development of OGA inhibitors as disease-modifying agents in both tauopathies and α-synucleinopathies.
Wed Apr 20 00:00:00 EDT 2022
Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology.
The Journal of clinical investigation
Sandusky-Beltran LA,Kovalenko A,Placides DS,Ratnasamy K,Ma C,Hunt JB,Liang H,Calahatian JIT,Michalski C,Fahnestock M,Blair LJ,Darling AL,Baker JD,Fontaine SN,Dickey CA,Gamsby JJ,Nash KR,Abner E,Selenica MB,Lee DC
MN1000B was used in Immunohistochemistry (Frozen) to report a unique interaction between polyamine metabolism, behavioral impairment, and tau fate.
Mon Feb 15 00:00:00 EST 2021
Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia.
Neuron
Wang C,Xiong M,Gratuze M,Bao X,Shi Y,Andhey PS,Manis M,Schroeder C,Yin Z,Madore C,Butovsky O,Artyomov M,Ulrich JD,Holtzman DM
MN1000B was used in Immunocytochemistry-immunoflourescence to investigate The cell-specific role of each form of apoE in the setting of neurodegeneration.
Wed May 19 00:00:00 EDT 2021
Apolipoprotein E4 Reduction with Antisense Oligonucleotides Decreases Neurodegeneration in a Tauopathy Model.
Annals of neurology
Litvinchuk A,Huynh TV,Shi Y,Jackson RJ,Finn MB,Manis M,Francis CM,Tran AC,Sullivan PM,Ulrich JD,Hyman BT,Cole T,Holtzman DM
MN1000B was used in Enzyme-linked immunosorbent assay to conclude that reducing ApoE4 levels should be explored further as a therapeutic approach for APOE4 carriers with tauopathy including Alzheimer's disease.
Sat May 01 00:00:00 EDT 2021
Syntenin-knock out reduces exosome turnover and viral transduction.
Scientific reports
Kashyap R,Balzano M,Lechat B,Lambaerts K,Egea-Jimenez AL,Lembo F,Fares J,Meeussen S,Kügler S,Roebroek A,David G,Zimmermann P
MN1000B was used in Immunohistochemistry to identify syntenin as part of dedicated machinery that integrates both the production and the uptake of secreted vesicles, supporting viral/exosomal exchanges.
Thu Feb 18 00:00:00 EST 2021
Syntenin-knock out reduces exosome turnover and viral transduction.
Scientific reports
Kashyap R,Balzano M,Lechat B,Lambaerts K,Egea-Jimenez AL,Lembo F,Fares J,Meeussen S,Kügler S,Roebroek A,David G,Zimmermann P
MN1000B was used in Immunohistochemistry to identify syntenin as part of dedicated machinery that integrates both the production and the uptake of secreted vesicles, supporting viral/exosomal exchanges.
Thu Feb 18 00:00:00 EST 2021
SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer's disease.
Molecular neurodegeneration
Bichmann M,Prat Oriol N,Ercan-Herbst E,Schöndorf DC,Gomez Ramos B,Schwärzler V,Neu M,Schlüter A,Wang X,Jin L,Hu C,Tian Y,Ried JS,Haberkant P,Gasparini L,Ehrnhoefer DE
MN1000B was used in ELISA to demonstrate that methylated Tau levels increase with Tau pathology stage in human AD samples as well as in a mouse model of Tauopathy.
Fri Jul 02 00:00:00 EDT 2021
Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration.
The Journal of clinical investigation
Gratuze M,Leyns CE,Sauerbeck AD,St-Pierre MK,Xiong M,Kim N,Serrano JR,Tremblay MÈ,Kummer TT,Colonna M,Ulrich JD,Holtzman DM
MN1000B was used in an ELISA assay to suggest that impaired TREM2 signaling reduces microglia-mediated neurodegeneration in the setting of tauopathy.
Tue Sep 01 00:00:00 EDT 2020
Anti-Aβ antibodies bound to neuritic plaques enhance microglia activity and mitigate tau pathology.
Acta neuropathologica communications
Laversenne V,Nazeeruddin S,Källstig EC,Colin P,Voize C,Schneider BL
MN1000B was used in Immunohistochemistry (Frozen) to enhance microglial activity around neuritic plaques, mitigating part of the tau-induced pathological manifestations.
Mon Nov 23 00:00:00 EST 2020
Anti-Aβ antibodies bound to neuritic plaques enhance microglia activity and mitigate tau pathology.
Acta neuropathologica communications
Laversenne V,Nazeeruddin S,Källstig EC,Colin P,Voize C,Schneider BL
MN1000B was used in Immunohistochemistry (Frozen) to enhance microglial activity around neuritic plaques, mitigating part of the tau-induced pathological manifestations.
Mon Nov 23 00:00:00 EST 2020
Tau reduction in aged mice does not impact Microangiopathy.
Acta neuropathologica communications
Bennett RE,Hu M,Fernandes A,Perez-Rando M,Robbins A,Kamath T,Dujardin S,Hyman BT
MN1000B was used in Immunocytochemistry-immunoflourescence to understand the nature of tau-related microangiopathy in human AD and in tau mice and examine whether this soluble tau is directly responsible for the microangiopathic changes.
Tue Aug 18 00:00:00 EDT 2020
Tau reduction in aged mice does not impact Microangiopathy.
Acta neuropathologica communications
Bennett RE,Hu M,Fernandes A,Perez-Rando M,Robbins A,Kamath T,Dujardin S,Hyman BT
MN1000B was used in Immunocytochemistry-immunoflourescence to understand the nature of tau-related microangiopathy in human AD and in tau mice and examine whether this soluble tau is directly responsible for the microangiopathic changes.
Tue Aug 18 00:00:00 EDT 2020
Tau affects P53 function and cell fate during the DNA damage response.
Communications biology
Sola M,Magrin C,Pedrioli G,Pinton S,Salvadè A,Papin S,Paganetti P
MN1000B was used in Immunoprecipitation to show that altered P53 stability and activity result in reduced cell death and increased cell senescence.
Tue May 19 00:00:00 EDT 2020
Tau affects P53 function and cell fate during the DNA damage response.
Communications biology
Sola M,Magrin C,Pedrioli G,Pinton S,Salvadè A,Papin S,Paganetti P
MN1000B was used in Immunoprecipitation to show that altered P53 stability and activity result in reduced cell death and increased cell senescence.
Tue May 19 00:00:00 EDT 2020
Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model.
The Journal of experimental medicine
Shi Y,Manis M,Long J,Wang K,Sullivan PM,Remolina Serrano J,Hoyle R,Holtzman DM
MN1000B was used in an ELISA assay to demonstrate that microglial activation is the driving force of neurodegeneration in the setting of tauopathy in a mouse model.
Mon Nov 04 00:00:00 EST 2019
Repetitive Diffuse Mild Traumatic Brain Injury Causes an Atypical Astrocyte Response and Spontaneous Recurrent Seizures.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Shandra O,Winemiller AR,Heithoff BP,Munoz-Ballester C,George KK,Benko MJ,Zuidhoek IA,Besser MN,Curley DE,Edwards GF,Mey A,Harrington AN,Kitchen JP,Robel S
MN1000B was used in Immunohistochemistry to show that repetitive diffuse TBI is sufficient for the development of spontaneous recurrent seizures in a subset of mice.
Wed Mar 06 00:00:00 EST 2019
Chronic PD-1 Checkpoint Blockade Does Not Affect Cognition or Promote Tau Clearance in a Tauopathy Mouse Model.
Frontiers in aging neuroscience
Lin Y,Rajamohamedsait HB,Sandusky-Beltran LA,Gamallo-Lana B,Mar A,Sigurdsson EM
Published figure using Tau monoclonal antibody (Product # MN1000B) in ELISA
Mon Sep 28 00:00:00 EDT 2020
Targeting tauopathy with engineered tau-degrading intrabodies.
Molecular neurodegeneration
Gallardo G,Wong CH,Ricardez SM,Mann CN,Lin KH,Leyns CEG,Jiang H,Holtzman DM
Published figure using Tau monoclonal antibody (Product # MN1000B) in Immunohistochemistry
Tue Oct 22 00:00:00 EDT 2019
Targeting tauopathy with engineered tau-degrading intrabodies.
Molecular neurodegeneration
Gallardo G,Wong CH,Ricardez SM,Mann CN,Lin KH,Leyns CEG,Jiang H,Holtzman DM
Published figure using Tau monoclonal antibody (Product # MN1000B) in Immunohistochemistry
Tue Oct 22 00:00:00 EDT 2019
Targeting tauopathy with engineered tau-degrading intrabodies.
Molecular neurodegeneration
Gallardo G,Wong CH,Ricardez SM,Mann CN,Lin KH,Leyns CEG,Jiang H,Holtzman DM
Published figure using Tau monoclonal antibody (Product # MN1000B) in Immunohistochemistry
Tue Oct 22 00:00:00 EDT 2019
Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease.
Neuron
Eftekharzadeh B,Daigle JG,Kapinos LE,Coyne A,Schiantarelli J,Carlomagno Y,Cook C,Miller SJ,Dujardin S,Amaral AS,Grima JC,Bennett RE,Tepper K,DeTure M,Vanderburg CR,Corjuc BT,DeVos SL,Gonzalez JA,Chew J,Vidensky S,Gage FH,Mertens J,Troncoso J,Mandelkow E,Salvatella X,Lim RYH,Petrucelli L,Wegmann S,Rothstein JD,Hyman BT
MN1000B was used in ELISA, Immunohistochemistry to show that tau can directly interact with nucleoporins of the nuclear pore complex (NPC) and affect their structural and functional integrity.
Wed Sep 05 00:00:00 EDT 2018
Tau protein liquid-liquid phase separation can initiate tau aggregation.
The EMBO journal
Wegmann S,Eftekharzadeh B,Tepper K,Zoltowska KM,Bennett RE,Dujardin S,Laskowski PR,MacKenzie D,Kamath T,Commins C,Vanderburg C,Roe AD,Fan Z,Molliex AM,Hernandez-Vega A,Muller D,Hyman AA,Mandelkow E,Taylor JP,Hyman BT
MN1000B was used in an ELISA assay to propose that soluble tau species can undergo liquid-liquid phase separation under cellular conditions and that phase-separated tau droplets can serve as an intermediate toward tau aggregate formation.
Tue Apr 03 00:00:00 EDT 2018
Detection of Alzheimer Disease (AD)-Specific Tau Pathology in AD and NonAD Tauopathies by Immunohistochemistry With Novel Conformation-Selective Tau Antibodies.
Journal of neuropathology and experimental neurology
Gibbons GS,Banks RA,Kim B,Changolkar L,Riddle DM,Leight SN,Irwin DJ,Trojanowski JQ,Lee VMY
MN1000B was used in an ELISA assay to identify novel tau monoclonal antibodies that selectively bind to an Alzheimer disease-specific conformation of pathological tau.
Thu Mar 01 00:00:00 EST 2018
APOE ε2 is associated with increased tau pathology in primary tauopathy.
Nature communications
Zhao N,Liu CC,Van Ingelgom AJ,Linares C,Kurti A,Knight JA,Heckman MG,Diehl NN,Shinohara M,Martens YA,Attrebi ON,Petrucelli L,Fryer JD,Wszolek ZK,Graff-Radford NR,Caselli RJ,Sanchez-Contreras MY,Rademakers R,Murray ME,Koga S,Dickson DW,Ross OA,Bu G
Published figure using Tau monoclonal antibody (Product # MN1000B) in Western Blot
Mon Oct 22 00:00:00 EDT 2018
Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy.
Redox biology
Cuadrado A,Kügler S,Lastres-Becker I
MN1000B was used in Immunohistochemistry to investigate whether dimethyl fumarat, an inducer of the transcription factor NRF2, could mitigate tauopathy in a mouse model.
Sun Apr 01 00:00:00 EDT 2018
ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy.
Nature
Shi Y,Yamada K,Liddelow SA,Smith ST,Zhao L,Luo W,Tsai RM,Spina S,Grinberg LT,Rojas JC,Gallardo G,Wang K,Roh J,Robinson G,Finn MB,Jiang H,Sullivan PM,Baufeld C,Wood MW,Sutphen C,McCue L,Xiong C,Del-Aguila JL,Morris JC,Cruchaga C,Fagan AM,Miller BL,Boxer AL,Seeley WW,Butovsky O,Barres BA,Paul SM,Holtzman DM
Thu Sep 28 00:00:00 EDT 2017
ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy.
Nature
Shi Y,Yamada K,Liddelow SA,Smith ST,Zhao L,Luo W,Tsai RM,Spina S,Grinberg LT,Rojas JC,Gallardo G,Wang K,Roh J,Robinson G,Finn MB,Jiang H,Sullivan PM,Baufeld C,Wood MW,Sutphen C,McCue L,Xiong C,Del-Aguila JL,Morris JC,Cruchaga C,Fagan AM,Miller BL,Boxer AL,Seeley WW,Butovsky O,Barres BA,Paul SM,Holtzman DM
Thu Sep 28 00:00:00 EDT 2017
Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro.
The American journal of pathology
Nobuhara CK,DeVos SL,Commins C,Wegmann S,Moore BD,Roe AD,Costantino I,Frosch MP,Pitstick R,Carlson GA,Hock C,Nitsch RM,Montrasio F,Grimm J,Cheung AE,Dunah AW,Wittmann M,Bussiere T,Weinreb PH,Hyman BT,Takeda S
MN1000B was used in an ELISA assay to discover that not all antibodies/epitopes are equally robust in terms of blocking tau uptake of human AD-derived tau species.
Thu Jun 01 00:00:00 EDT 2017
The use of mouse models to study cell-to-cell transmission of pathological tau.
Methods in cell biology
Narasimhan S,Lee VMY
Fri Jun 01 00:00:00 EDT 2018
Increased 4R-Tau Induces Pathological Changes in a Human-Tau Mouse Model.
Neuron
Schoch KM,DeVos SL,Miller RL,Chun SJ,Norrbom M,Wozniak DF,Dawson HN,Bennett CF,Rigo F,Miller TM
Published figure using Tau monoclonal antibody (Product # MN1000B) in ELISA
Wed Jun 01 00:00:00 EDT 2016
Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes.
Autophagy
Pajares M,Jiménez-Moreno N,García-Yagüe ÁJ,Escoll M,de Ceballos ML,Van Leuven F,Rábano A,Yamamoto M,Rojo AI,Cuadrado A
MN1000B was used in immunohistochemistry - free floating, immunohistochemistry - paraffin section, and western blot to identify NFE2L2/NRF2 as a regulator of autophagy gene expression and study its role in Alzheimer disease
Sun Oct 02 00:00:00 EDT 2016
Vectored Intracerebral Immunization with the Anti-Tau Monoclonal Antibody PHF1 Markedly Reduces Tau Pathology in Mutant Tau Transgenic Mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Liu W,Zhao L,Blackman B,Parmar M,Wong MY,Woo T,Yu F,Chiuchiolo MJ,Sondhi D,Kaminsky SM,Crystal RG,Paul SM
MN1000B was used in ELISA to use direct intrahippocampal administration of the adeno-associated virus-vectored anti-phospho-tau antibody to reduce disease
Wed Dec 07 00:00:00 EST 2016
Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody.
Scientific reports
Luo W,Liu W,Hu X,Hanna M,Caravaca A,Paul SM
MN1000B was used in an ELISA assay to identify a potential role for microglia in the degradation and clearance of pathological tau species in the brain.
Tue Jun 09 00:00:00 EDT 2015
Increased expression of the receptor for advanced glycation end products in neurons and astrocytes in a triple transgenic mouse model of Alzheimer's disease.
Experimental & molecular medicine
Choi BR,Cho WH,Kim J,Lee HJ,Chung C,Jeon WK,Han JS
MN1000B was used in immunohistochemistry to study the elevated neuronal and astrocyte expression of RAGE in a murine transgenic model of Alzheimer's disease
Fri Feb 07 00:00:00 EST 2014
Synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of Alzheimer's disease.
Neurobiology of disease
Chabrier MA,Cheng D,Castello NA,Green KN,LaFerla FM
MN1000B was used in immunohistochemistry and western blot to study dendritic spine loss in a transgenic murine model of Alzheimer's disease and the synergistic effects of Abeta and tau
Tue Apr 01 00:00:00 EDT 2014
Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition.
Neurobiology of disease
Baglietto-Vargas D,Kitazawa M,Le EJ,Estrada-Hernandez T,Rodriguez-Ortiz CJ,Medeiros R,Green KN,LaFerla FM
MN1000B was used in western blot to study the effect of endogenous murine tau on cognition and neurofibrillary tangles in a murine Alzheimer's disease model transgenically expressing human tau
Sat Feb 01 00:00:00 EST 2014
Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Castillo-Carranza DL,Sengupta U,Guerrero-Muñoz MJ,Lasagna-Reeves CA,Gerson JE,Singh G,Estes DM,Barrett AD,Dineley KT,Jackson GR,Kayed R
MN1000B was used in ELISA and immunohistochemistry to study the ability of an anti-oligomeric tau monoclonal antibody to specifically reduce oligomeric tau and improve memory and locomotion in a murine Alzheimer's disease model
Wed Mar 19 00:00:00 EDT 2014
Suppression of InsP3 receptor-mediated Ca2+ signaling alleviates mutant presenilin-linked familial Alzheimer's disease pathogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Shilling D,Müller M,Takano H,Mak DO,Abel T,Coulter DA,Foskett JK
MN1000B was used in western blot to study the role of exagerated Ca(2+) signaling mediated by InsP3 receptor1 in the pathogenesis of mutant presenilin-linked Alzheimer's disease
Wed May 14 00:00:00 EDT 2014
Premature lethality, hyperactivity, and aberrant phosphorylation in transgenic mice expressing a constitutively active form of Fyn.
Frontiers in molecular neuroscience
Xia D,Götz J
MN1000B was used in western blot to study the effects of transgenically expressing a constitutively active Y531F Fyn mutant on murine life-span, activity and protein phosphorylation
Mon May 26 00:00:00 EDT 2014
Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice.
Experimental neurology
Yamada ES,Respondek G,Müssner S,de Andrade A,Höllerhage M,Depienne C,Rastetter A,Tarze A,Friguet B,Salama M,Champy P,Oertel WH,Höglinger GU
MN1000B was used in western blot to study the increased tau phosphorylation following treatment with a mitochondrial complex I inhibitor in a tau transgenic mouse model
Sat Mar 01 00:00:00 EST 2014
Sleep deprivation impairs memory, tau metabolism, and synaptic integrity of a mouse model of Alzheimer's disease with plaques and tangles.
Neurobiology of aging
Di Meco A,Joshi YB,Praticò D
MN1000B was used in western blot to study the deleterious effects of sleep deprivation on memory and Tau pathology in a murine Alzheimer's disease model
Fri Aug 01 00:00:00 EDT 2014
Age-related downregulation of the CaV3.1 T-type calcium channel as a mediator of amyloid beta production.
Neurobiology of aging
Rice RA,Berchtold NC,Cotman CW,Green KN
MN1000B was used in immunohistochemistry and western blot to study the potential mechanism by which the age-related decline in CaV3.1 T-type calcium channel expression leads to increased production of beta-amyloid
Thu May 01 00:00:00 EDT 2014
Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology.
Neurobiology of aging
Orr ME,Salinas A,Buffenstein R,Oddo S
MN1000B was used in western blot to study the role of mTOR hyperactivation in the mechanism by which a high-sucrose diet promotes beta-amyloid pathology in Alzheimer's disease
Sun Jun 01 00:00:00 EDT 2014
Practical detection of a definitive biomarker panel for Alzheimer's disease; comparisons between matched plasma and cerebrospinal fluid.
International journal of molecular epidemiology and genetics
Richens JL,Vere KA,Light RA,Soria D,Garibaldi J,Smith AD,Warden D,Wilcock G,Bajaj N,Morgan K,O'Shea P
MN1000B was used in Luminex assays to characterise a definitive biomarker panel for Alzheimer''s disease, including the diagnostic capacity of samples from the cerebrospinal fluid and the blood.
Tue Jun 24 00:00:00 EDT 2014
Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology.
Biological psychiatry
Baglietto-Vargas D,Medeiros R,Martinez-Coria H,LaFerla FM,Green KN
MN1000B was used in western blot to study the reduced alpha- and beta-cleavage of APP and reduced phosporylated tau accumulation in transgenic mice treated with mifepristone
Sun Sep 01 00:00:00 EDT 2013
Tau-tubulin kinase 1 expression, phosphorylation and co-localization with phospho-Ser422 tau in the Alzheimer's disease brain.
Brain pathology (Zurich, Switzerland)
Lund H,Cowburn RF,Gustafsson E,Strömberg K,Svensson A,Dahllund L,Malinowsky D,Sunnemark D
MN1000B was used in ELISA to investigate the characteristics of TTBK1 in the brain of AD patients
Mon Jul 01 00:00:00 EDT 2013
Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy.
Neurobiology of aging
Nash KR,Lee DC,Hunt JB,Morganti JM,Selenica ML,Moran P,Reid P,Brownlow M,Guang-Yu Yang C,Savalia M,Gemma C,Bickford PC,Gordon MN,Morgan D
MN1000B was used in western blot to study the beneficial effects on tau pathology in a murine transgenic tauopathy model of the virally-mediated overexpression of soluble fractalkine
Sat Jun 01 00:00:00 EDT 2013
Impact of N-tau on adult hippocampal neurogenesis, anxiety, and memory.
Neurobiology of aging
Pristerà A,Saraulli D,Farioli-Vecchioli S,Strimpakos G,Costanzi M,di Certo MG,Cannas S,Ciotti MT,Tirone F,Mattei E,Cestari V,Canu N
MN1000B was used in immunocytochemistry and immunohistochemistry to study the effects of a pathogenic tau fragment on hippocampal neurogenesis, behaviour and learning
Fri Nov 01 00:00:00 EDT 2013
Active glycogen synthase kinase-3 and tau pathology-related tyrosine phosphorylation in pR5 human tau transgenic mice.
Neurobiology of aging
Köhler C,Dinekov M,Götz J
MN1000B was used in western blot to study the association of GSK3 activity with tau phosphorylation and neuronal tyrosine phosphorylation in a murine model expressing human P301L tau
Wed May 01 00:00:00 EDT 2013
Increasing brain protein O-GlcNAc-ylation mitigates breathing defects and mortality of Tau.P301L mice.
PloS one
Borghgraef P,Menuet C,Theunis C,Louis JV,Devijver H,Maurin H,Smet-Nocca C,Lippens G,Hilaire G,Gijsen H,Moechars D,Van Leuven F
MN1000B was used in immunohistochemistry, immunoprecipitation, and western blot to study the beneficial effects of increasing the O-GlucNAcylation of brain proteins on the survival and breathing of aged tau P301L transgenic mice
Mon Oct 13 00:00:00 EDT 2014
Impaired plasticity of cortical dendritic spines in P301S tau transgenic mice.
Acta neuropathologica communications
Hoffmann NA,Dorostkar MM,Blumenstock S,Goedert M,Herms J
MN1000B was used in immunohistochemistry to study the potential involvement of pre-fibrilliary tau in the defective plasticity of cortical dendritic spines observed in transgenic mice bearing the P301S tau mutation
Tue Dec 17 00:00:00 EST 2013
PINCH in the cellular stress response to tau-hyperphosphorylation.
PloS one
Ozdemir AY,Rom I,Kovalevich J,Yen W,Adiga R,Dave RS,Langford D
MN1000B was used in western blot to study the ability of PINCH in bind and stabilize hyperphoshorylated tau
Mon Sep 30 00:00:00 EDT 2013
Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers.
Brain : a journal of neurology
Attar A,Ripoli C,Riccardi E,Maiti P,Li Puma DD,Liu T,Hayes J,Jones MR,Lichti-Kaiser K,Yang F,Gale GD,Tseng CH,Tan M,Xie CW,Straudinger JL,Klärner FG,Schrader T,Frautschy SA,Grassi C,Bitan G
MN1000B was used in immunohistochemistry to study the ability of lysine-specific molecular tweezers to protect against Alzheimer's disease pathology
Sat Dec 01 00:00:00 EST 2012
The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Zhang B,Carroll J,Trojanowski JQ,Yao Y,Iba M,Potuzak JS,Hogan AM,Xie SX,Ballatore C,Smith AB,Lee VM,Brunden KR
MN1000B was used in ELISA to study mechaisms underlying the therapeutic effects of epothilone D in a murine transgenic tau model and the significance for Alzheimer's disease
Wed Mar 14 00:00:00 EDT 2012
Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice.
The American journal of pathology
Medeiros R,Kitazawa M,Chabrier MA,Cheng D,Baglietto-Vargas D,Kling A,Moeller A,Green KN,LaFerla FM
MN1000B was used in western blot to study the beneficial effects of a novel calpain inhibitor on Alzheimers's disease pathology and cognitive decline in transgenic mouse model
Wed Aug 01 00:00:00 EDT 2012
Altered expression of brain acetylcholinesterase in FTDP-17 human tau transgenic mice.
Neurobiology of aging
Silveyra MX,García-Ayllón MS,de Barreda EG,Small DH,Martínez S,Avila J,Sáez-Valero J
MN1000B was used in western blot to identify the relationship between acetylcholinesterase and P-tau expression in neurodegeneration
Thu Mar 01 00:00:00 EST 2012
Frontal cortex neuropathology in dementia pugilistica.
Journal of neurotrauma
Saing T,Dick M,Nelson PT,Kim RC,Cribbs DH,Head E
MN1000B was used in immunohistochemistry to investigate the neuropathological changes in dementia pugilistica patients
Tue Apr 10 00:00:00 EDT 2012
Wild type and P301L mutant Tau promote neuro-inflammation and α-Synuclein accumulation in lentiviral gene delivery models.
Molecular and cellular neurosciences
Khandelwal PJ,Dumanis SB,Herman AM,Rebeck GW,Moussa CE
MN1000B was used in western blot to investigate the effects of wild type and P301L mutant tau on neuro-inflammation and alpha-synuclein accumulation in a rat model
Sun Jan 01 00:00:00 EST 2012
Effects of the superoxide dismutase/catalase mimetic EUK-207 in a mouse model of Alzheimer's disease: protection against and interruption of progression of amyloid and tau pathology and cognitive decline.
Journal of Alzheimer's disease : JAD
Clausen A,Xu X,Bi X,Baudry M
MN1000B was used in immunohistochemistry to study the role of oxidative stress in Alzheimer's disease pathogenesis and progression
Mon Sep 10 00:00:00 EDT 2012
Clinical, neuropathological, and biochemical characterization of the novel tau mutation P332S.
Journal of Alzheimer's disease : JAD
Deramecourt V,Lebert F,Maurage CA,Fernandez-Gomez FJ,Dujardin S,Colin M,Sergeant N,Buée-Scherrer V,Clot F,Ber IL,Brice A,Pasquier F,Buée L
MN1000B was used in western blot to study the clinical and molecular characteristics of a novel P332S tau mutation
Mon Jul 08 00:00:00 EDT 2013
Prolonged nitric oxide treatment induces tau aggregation in SH-SY5Y cells.
Neuroscience letters
Takahashi M,Chin Y,Nonaka T,Hasegawa M,Watanabe N,Arai T
MN1000B was used in western blot to investigate the effect of prolonged NO treatment on the aggregation of tau in SH-SY5Y cells
Tue Feb 21 00:00:00 EST 2012
Hippocampal BDNF expression in a tau transgenic mouse model.
Current Alzheimer research
Burnouf S,Belarbi K,Troquier L,Derisbourg M,Demeyer D,Leboucher A,Laurent C,Hamdane M,Buee L,Blum D
MN1000B was used in western blot to study whether tau pathology is associated with BDNF downregulation in a transgenic mouse model
Tue May 01 00:00:00 EDT 2012
LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth.
PloS one
Kawakami F,Yabata T,Ohta E,Maekawa T,Shimada N,Suzuki M,Maruyama H,Ichikawa T,Obata F
MN1000B was used in western blot to investigate the important roles of LRRK2 in phosphorylation-mediated dissociation of tau from microtubules
Mon Jun 11 00:00:00 EDT 2012
Membrane-microdomain localization of amyloid β-precursor protein (APP) C-terminal fragments is regulated by phosphorylation of the cytoplasmic Thr668 residue.
The Journal of biological chemistry
Matsushima T,Saito Y,Elliott JI,Iijima-Ando K,Nishimura M,Kimura N,Hata S,Yamamoto T,Nakaya T,Suzuki T
MN1000B was used in western blot to study the role of phosphorylation in the membrane-microdomain localization of amyloid ?-precursor protein C-terminal fragments
Fri Jun 01 00:00:00 EDT 2012
Human P301L-mutant tau expression in mouse entorhinal-hippocampal network causes tau aggregation and presynaptic pathology but no cognitive deficits.
PloS one
Harris JA,Koyama A,Maeda S,Ho K,Devidze N,Dubal DB,Yu GQ,Masliah E,Mucke L
MN1000B was used in immunohistochemistry to study whether tau pathology caused by overexpression of mutant P301L tau in the murine entorhinal-hippocampal network leads to cognitive defects
Thu Feb 28 00:00:00 EST 2013
A peculiar constellation of tau pathology defines a subset of dementia in the elderly.
Acta neuropathologica
Kovacs GG,Molnár K,László L,Ströbel T,Botond G,Hönigschnabl S,Reiner-Concin A,Palkovits M,Fischer P,Budka H
MN1000B was used in immunohistochemistry to investigate the changes of tau pattern in some older patients with dementia
Mon Aug 01 00:00:00 EDT 2011
Morin attenuates tau hyperphosphorylation by inhibiting GSK3β.
Neurobiology of disease
Gong EJ,Park HR,Kim ME,Piao S,Lee E,Jo DG,Chung HY,Ha NC,Mattson MP,Lee J
MN1000B was used in immunohistochemistry to study the ability of the GSKbeta inhibitor morin to reduce tau hyperphosphorylation
Tue Nov 01 00:00:00 EDT 2011
Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-β accumulation and independently accelerates the development of tau abnormalities.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Tran HT,LaFerla FM,Holtzman DM,Brody DL
MN1000B was used in immunohistochemistry to investigate the effect of traumatic brain injury on the development of Alzheimer disease pathology
Wed Jun 29 00:00:00 EDT 2011
Loss of muscarinic M1 receptor exacerbates Alzheimer's disease-like pathology and cognitive decline.
The American journal of pathology
Medeiros R,Kitazawa M,Caccamo A,Baglietto-Vargas D,Estrada-Hernandez T,Cribbs DH,Fisher A,LaFerla FM
MN1000B was used in western blot to study the deleterious effects of muscarinic M1 receptor knockout on Alzheimer's disease pathology and cognitive decline in a transgenic mouse model
Mon Aug 01 00:00:00 EDT 2011
Tau transgenic mice as models for cerebrospinal fluid tau biomarkers.
Journal of Alzheimer's disease : JAD
Barten DM,Cadelina GW,Hoque N,DeCarr LB,Guss VL,Yang L,Sankaranarayanan S,Wes PD,Flynn ME,Meredith JE,Ahlijanian MK,Albright CF
MN1000B was used in immunohistochemistry to detect Tau protein in cerebrospinal fluid
Fri Sep 30 00:00:00 EDT 2011
Long term changes in phospho-APP and tau aggregation in the 3xTg-AD mice following cerebral ischemia.
Neuroscience letters
Koike MA,Garcia FG,Kitazawa M,Green KN,Laferla FM
MN1000B was used in western blot to investigate the phosphorylation and aggregation of tau protein in the 3xTg-AD mice
Mon May 09 00:00:00 EDT 2011
Hippocampal tauopathy in tau transgenic mice coincides with impaired hippocampus-dependent learning and memory, and attenuated late-phase long-term depression of synaptic transmission.
Neurobiology of learning and memory
Van der Jeugd A,Ahmed T,Burnouf S,Belarbi K,Hamdame M,Grosjean ME,Humez S,Balschun D,Blum D,Buée L,D'Hooge R
MN1000B was used in western blot to investigate the influence of hippocampal tauopathy in learning, memory and neural functions in transgenic mice
Tue Mar 01 00:00:00 EST 2011
6-amino-4-(pyrimidin-4-yl)pyridones: novel glycogen synthase kinase-3β inhibitors.
Bioorganic & medicinal chemistry letters
Coffman K,Brodney M,Cook J,Lanyon L,Pandit J,Sakya S,Schachter J,Tseng-Lovering E,Wessel M
MN1000B was used in immunoprecipitation to identify and characterize a novel class of GSK3 beta inhibitors
Tue Mar 01 00:00:00 EST 2011
Early oligodendrocyte/myelin pathology in Alzheimer's disease mice constitutes a novel therapeutic target.
The American journal of pathology
Desai MK,Mastrangelo MA,Ryan DA,Sudol KL,Narrow WC,Bowers WJ
MN1000B was used in immunohistochemistry to investigate the effect of Abeta(1-42) on the survival of mOP cells in Alzheimer disease mouse model
Wed Sep 01 00:00:00 EDT 2010
Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice.
The American journal of pathology
Martinez-Coria H,Green KN,Billings LM,Kitazawa M,Albrecht M,Rammes G,Parsons CG,Gupta S,Banerjee P,LaFerla FM
MN1000B was used in western blot to investigate the effect of memantine on Alzheimer disease treatment in mice
Mon Feb 01 00:00:00 EST 2010
GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease.
Journal of Alzheimer's disease : JAD
Li Y,Duffy KB,Ottinger MA,Ray B,Bailey JA,Holloway HW,Tweedie D,Perry T,Mattson MP,Kapogiannis D,Sambamurti K,Lahiri DK,Greig NH
MN1000B was used in western blot to investigate the effect of GLP-1 receptor stimulation on amyloid-beta peptide accumulation and cytotoxicity in Alzheimer disease model
Thu Jul 22 00:00:00 EDT 2010
Gateway-compatible lentiviral transfer vectors for ubiquitin promoter driven expression of fluorescent fusion proteins.
Plasmid
Krupka N,Strappe P,Götz J,Ittner LM
MN1000B was used in western blot to evaluate the transfection vector for fluorescent fusion protei expression in 293T and SH-SY5Y cells
Sat May 01 00:00:00 EDT 2010
Spatially pathogenic forms of tau detected in Alzheimer's disease brain tissue by fluorescence lifetime-based Förster resonance energy transfer.
Journal of neuroscience methods
Larionov S,Wielgat P,Wang Y,Thal DR,Neumann H
MN1000B was used in immunohistochemistry to develop a FRET-based method to detect pathogenic forms of tau.
Thu Sep 30 00:00:00 EDT 2010
Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice.
PloS one
Bittner T,Fuhrmann M,Burgold S,Ochs SM,Hoffmann N,Mitteregger G,Kretzschmar H,LaFerla FM,Herms J
MN1000B was used in immunohistochemistry to investigate the dendritic spine loss during the progression of Alzheimer disease in a mouse model
Tue Nov 16 00:00:00 EST 2010
A cellular model to monitor proteasome dysfunction by alpha-synuclein.
Biochemistry
Nonaka T,Hasegawa M
MN1000B was used in western blot to study the effect of alpha-synuclein on proteasome function
Tue Aug 25 00:00:00 EDT 2009
Detailed immunohistochemical characterization of temporal and spatial progression of Alzheimer's disease-related pathologies in male triple-transgenic mice.
BMC neuroscience
Mastrangelo MA,Bowers WJ
MN1000B was used in immunohistochemistry to study the temporal and spatial progression of AD-like pathology in male 3xTg-AD mice
Tue Aug 12 00:00:00 EDT 2008
Biochemical characterization of Abeta and tau pathologies in mild cognitive impairment and Alzheimer's disease.
Journal of Alzheimer's disease : JAD
Tremblay C,Pilote M,Phivilay A,Emond V,Bennett DA,Calon F
MN1000B was used in western blot to quantify the abeta and tau pathologies in mild cognitive impairment and Alzheimer disease
Sat Dec 01 00:00:00 EST 2007
Tau in cerebrospinal fluid: a sensitive sandwich enzyme-linked immunosorbent assay using tyramide signal amplification.
Neuroscience letters
Yamamori H,Khatoon S,Grundke-Iqbal I,Blennow K,Ewers M,Hampel H,Iqbal K
MN1000B was used in ELISA to develop a novel ELISA assay for quantification of tau in cerebrospinal fluid
Thu May 17 00:00:00 EDT 2007
