Product References
CREB3L2-ATF4 heterodimerization defines a transcriptional hub of Alzheimer's disease gene expression linked to neuropathology.
Science advances
Gouveia Roque C,Chung KM,McCurdy EP,Jagannathan R,Randolph LK,Herline-Killian K,Baleriola J,Hengst U
MN1000 was used in ELISA, Immunohistochemistry - Free Floating, Immunohistochemistry (Paraffin), Western Blot to reveal differential transcription factor dimerization as a mechanism linking disease stimuli to the development of pathogenic cellular states.
Fri Mar 03 00:00:00 EST 2023
Neuronal loss of NCLX-dependent mitochondrial calcium efflux mediates age-associated cognitive decline.
iScience
Jadiya P,Cohen HM,Kolmetzky DW,Kadam AA,Tomar D,Elrod JW
MN1000 was used in Immunohistochemistry (Paraffin) to demonstrate that loss of NCLX-dependent mCa2+ efflux alone is sufficient to induce an Alzheimer's disease-like pathology and highlights the promise of therapies targeting mCa2+ exchange.
Fri Mar 17 00:00:00 EDT 2023
Neuronal loss of NCLX-dependent mitochondrial calcium efflux mediates age-associated cognitive decline.
iScience
Jadiya P,Cohen HM,Kolmetzky DW,Kadam AA,Tomar D,Elrod JW
MN1000 was used in Immunohistochemistry (Paraffin) to demonstrate that loss of NCLX-dependent mCa2+ efflux alone is sufficient to induce an Alzheimer's disease-like pathology and highlights the promise of therapies targeting mCa2+ exchange.
Fri Mar 17 00:00:00 EDT 2023
Tau protein binds to the P53 E3 ubiquitin ligase MDM2.
Scientific reports
Sola M,Rendon-Angel A,Rojo Martinez V,Sgrignani J,Magrin C,Piovesana E,Cavalli A,Paganetti P,Papin S
MN1000 was used in Western Blotting to report the existence in cells and brain of a Tau-MDM2 complex that, in vitro, exhibits reduced P53 ubiquitination activity in a manner sensitive to a Tau mutation.
Fri Jun 23 00:00:00 EDT 2023
Focused ultrasound mitigates pathology and improves spatial memory in Alzheimer's mice and patients.
Theranostics
Karakatsani ME,Ji R,Murillo MF,Kugelman T,Kwon N,Lao YH,Liu K,Pouliopoulos AN,Honig LS,Duff KE,Konofagou EE
MN1000 was used in Immunohistochemistry (Frozen) to investigate the effects of repeated bilateral sonications in the presence of both pathologies.
Thu Aug 10 00:00:00 EDT 2023
Mutant β1-adrenergic receptor improves REM sleep and ameliorates tau accumulation in a mouse model of tauopathy.
Proceedings of the National Academy of Sciences of the United States of America
Dong Q,Ptáček LJ,Fu YH
MN1000 was used in Western Blot to test the effect of another familial natural short sleep (FNSS) gene variant, Adrb1-A187V, by crossing mice with this mutation onto the PS19 background.
Tue Apr 11 00:00:00 EDT 2023
Characterization of the Tau Interactome in Human Brain Reveals Isoform-Dependent Interaction with 14-3-3 Family Proteins.
eNeuro
Betters RK,Luhmann E,Gottschalk AC,Xu Z,Shin MR,Ptak CP,Fiock KL,Radoshevich LC,Hefti MM
MN1000 was used in ELISA, Immunohistochemistry - Free Floating, Immunohistochemistry (Paraffin), Western Blot, Immunoprecipitation to suggest that there are isoform-driven differences between the phospho-tau interactome in fetal and Alzheimer's disease brain, including differences in interaction with the critical 14-3-3 family of protein chaperones, which may explain, in part, the resilience of fetal brain to tau toxicity.
Wed Mar 01 00:00:00 EST 2023
Neurodegeneration risk factor, EIF2AK3 (PERK), influences tau protein aggregation.
The Journal of biological chemistry
Park G,Xu K,Chea L,Kim K,Safarta L,Song KH,Wu J,Park S,Min H,Hiramatsu N,Han J,Lin JH
MN1000 was used in ELISA, Immunohistochemistry - Free Floating, Immunohistochemistry (Paraffin), Western Blot to identify small-molecule augmentation of protein kinase R-like endoplasmic reticulum kinase signaling as an attractive therapeutic strategy to treat tauopathies by preventing tau pathology.
Wed Feb 01 00:00:00 EST 2023
Neurodegeneration risk factor, EIF2AK3 (PERK), influences tau protein aggregation.
The Journal of biological chemistry
Park G,Xu K,Chea L,Kim K,Safarta L,Song KH,Wu J,Park S,Min H,Hiramatsu N,Han J,Lin JH
MN1000 was used in ELISA, Immunohistochemistry - Free Floating, Immunohistochemistry (Paraffin), Western Blot to identify small-molecule augmentation of protein kinase R-like endoplasmic reticulum kinase signaling as an attractive therapeutic strategy to treat tauopathies by preventing tau pathology.
Wed Feb 01 00:00:00 EST 2023
Tau seeding and spreading in vivo is supported by both AD-derived fibrillar and oligomeric tau.
Acta neuropathologica
Mate De Gerando A,Welikovitch LA,Khasnavis A,Commins C,Glynn C,Chun JE,Perbet R,Hyman BT
MN1000 was used in Immunodepletion to suggest that soluble HMW tau has similar properties to fibrillar sarkosyl-insoluble tau with regard to tau seeding potential, but may be equal or even more bioactive with respect to propagation across neural systems and activation of glial responses, both relevant to tau-related Alzheimer phenotypes.
Tue Aug 01 00:00:00 EDT 2023
Mass spectrometric simultaneous quantification of tau species in plasma shows differential associations with amyloid and tau pathologies.
Nature aging
Montoliu-Gaya L,Benedet AL,Tissot C,Vrillon A,Ashton NJ,Brum WS,Lantero-Rodriguez J,Stevenson J,Nilsson J,Sauer M,Rahmouni N,Brinkmalm G,Lussier FZ,Pascoal TA,Skoog I,Kern S,Zetterberg H,Paquet C,Gobom J,Rosa-Neto P,Blennow K
MN1000 was used in Mass Spectrometry to support the differential association of blood p-tau variants with AD pathology, and our method offers a potential tool for disease staging in clinical trials.
Thu Jun 01 00:00:00 EDT 2023
Alzheimer's disease associated AKAP9 I2558M mutation alters posttranslational modification and interactome of tau and cellular functions in CRISPR-edited human neuronal cells.
Aging cell
You Y,Hersh SW,Aslebagh R,Shaffer SA,Ikezu S,Mez J,Lunetta KL,Logue MW,Farrer LA,Ikezu T
MN1000 was used in ELISA, Immunohistochemistry - Free Floating, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry to demonstrate specific effects of rs14462445 on mis-processing of tau and suggest a potential role of AKAP9 in AD pathogenesis.
Wed Jun 01 00:00:00 EDT 2022
Alpha-synuclein and tau are abundantly expressed in the ENS of the human appendix and monkey cecum.
PloS one
Zinnen AD,Vichich J,Metzger JM,Gambardella JC,Bondarenko V,Simmons HA,Emborg ME
MN1000 was used in ELISA, Immunohistochemistry - Free Floating, Immunohistochemistry (Paraffin), Western Blot to provide critical translational evidence that the common marmoset and rhesus macaque ceca are remarkably similar to the human appendix and, thus, that these NHP species are suitable for studying the development of PD linked to α-syn and tau pathological changes in the ENS.
Tue Jun 14 00:00:00 EDT 2022
Pterostilbene in Combination With Mitochondrial Cofactors Improve Mitochondrial Function in Cellular Models of Mitochondrial Diseases.
Frontiers in pharmacology
Suárez-Rivero JM,Pastor-Maldonado CJ,Romero-González A,Gómez-Fernandez D,Povea-Cabello S,Álvarez-Córdoba M,Villalón-García I,Talaverón-Rey M,Suárez-Carrillo A,Munuera-Cabeza M,Sánchez-Alcázar JA
MN1000 was used in ELISA, Immunohistochemistry- Free Floating, Immunohistochemistry (Paraffin), Western Blot to identify a potentially beneficial molecule, pterostilbene (a resveratrol analogue), as mitochondrial booster in drug screenings.
Tue Apr 05 00:00:00 EDT 2022
Association of Retromer Deficiency and Tau Pathology in Down Syndrome.
Annals of neurology
Curtis ME,Smith T,Yu D,Praticò D
MN1000 was used in Western Blotting to investigate retromer deficiency in Down syndrome.
Fri Apr 01 00:00:00 EDT 2022
Dysfunction of the retromer complex system contributes to amyloid and tau pathology in a stem cell model of Down syndrome.
Alzheimer's & dementia (New York, N. Y.)
Curtis ME,Smith T,Blass BE,Praticò D
MN1000 was used in Western Blotting to investigate whether retromer dysfunction contributes to the amyloid beta (Aβ) and tau neuropathology of Down syndrome.
Tue Aug 02 00:00:00 EDT 2022
Blocking Site-Specific Cleavage of Human Tau Delays Progression of Disease-Related Phenotypes in Genetically Matched Tau-Transgenic Mice Modeling Frontotemporal Dementia.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Steuer EL,Kemper LJ,Hlynialuk CJW,Leinonen-Wright K,Montonye ML,Lapcinski IP,Forster CL,Ashe KH,Liu P
MN1000 was used in ELISA, Immunohistochemistry - Free Floating, Immunohistochemistry (Paraffin), Western Blot to demonstrate that htau transgene expression occurs primarily in the forebrain at similar levels in rT2 and rT3 mice.
Wed Jun 08 00:00:00 EDT 2022
Blocking Site-Specific Cleavage of Human Tau Delays Progression of Disease-Related Phenotypes in Genetically Matched Tau-Transgenic Mice Modeling Frontotemporal Dementia.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Steuer EL,Kemper LJ,Hlynialuk CJW,Leinonen-Wright K,Montonye ML,Lapcinski IP,Forster CL,Ashe KH,Liu P
MN1000 was used in ELISA, Immunohistochemistry - Free Floating, Immunohistochemistry (Paraffin), Western Blot to demonstrate that htau transgene expression occurs primarily in the forebrain at similar levels in rT2 and rT3 mice.
Wed Jun 08 00:00:00 EDT 2022
Blocking Site-Specific Cleavage of Human Tau Delays Progression of Disease-Related Phenotypes in Genetically Matched Tau-Transgenic Mice Modeling Frontotemporal Dementia.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Steuer EL,Kemper LJ,Hlynialuk CJW,Leinonen-Wright K,Montonye ML,Lapcinski IP,Forster CL,Ashe KH,Liu P
MN1000 was used in ELISA, Immunohistochemistry - Free Floating, Immunohistochemistry (Paraffin), Western Blot to demonstrate that htau transgene expression occurs primarily in the forebrain at similar levels in rT2 and rT3 mice.
Wed Jun 08 00:00:00 EDT 2022
Functional imaging of brain organoids using high-density microelectrode arrays.
MRS bulletin
Schröter M,Wang C,Terrigno M,Hornauer P,Huang Z,Jagasia R,Hierlemann A
MN1000 was used in Immunohistochemistry-immunofluorescence to demonstrate that HD-MEAs provide a multi-purpose platform for the functional characterization of hCOs, which will be key in improving our understanding of this model system and assessing its relevance for translational research.
Wed Sep 28 00:00:00 EDT 2022
In vitro-derived medium spiny neurons recapitulate human striatal development and complexity at single-cell resolution.
Cell reports methods
Conforti P,Bocchi VD,Campus I,Scaramuzza L,Galimberti M,Lischetti T,Talpo F,Pedrazzoli M,Murgia A,Ferrari I,Cordiglieri C,Fasciani A,Arenas E,Felsenfeld D,Biella G,Besusso D,Cattaneo E
MN1000 was used in Western Blot to generate D1 and D2-medium spiny neurons (MSNs) from hESC, which eventually could facilitate cell-replacement therapies for Huntington’s disease (HD).
Mon Dec 19 00:00:00 EST 2022
Differential expression of tau species and the association with cognitive decline and synaptic loss in Alzheimer's disease.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Saroja SR,Sharma A,Hof PR,Pereira AC
MN1000 was used in Western Blot to propose that tau species from NFT-predominant tissues possess greater levels of degenerative properties, thereby causing synaptic loss and cognitive decline.
Thu Sep 01 00:00:00 EDT 2022
CASK loss of function differentially regulates neuronal maturation and synaptic function in human induced cortical excitatory neurons.
iScience
McSweeney D,Gabriel R,Jin K,Pang ZP,Aronow B,Pak C
MN1000 was used in ELISA, Immunohistochemistry - Free Floating, Immunohistochemistry (Paraffin), Western Blot to study cell-autonomous functions of CASK in cortical excitatory induced neurons (iNs) generated from CASK knockout (KO) isogenic human embryonic stem cells (hESCs) using gene expression, morphometrics, and electrophysiology.
Fri Oct 21 00:00:00 EDT 2022
Multiple pathways promote microtubule stabilization in senescent intestinal epithelial cells.
npj aging
Chu S,Moujaber O,Lemay S,Stochaj U
MN1000 was used in ELISA, Immunohistochemistry - Free Floating, Immunohistochemistry (Paraffin), Western Blot to provide new insights into the molecular mechanisms that control epithelial cell homeostasis.
Fri Dec 16 00:00:00 EST 2022
Dual-Specificity Protein Phosphatase 4 (DUSP4) Overexpression Improves Learning Behavior Selectively in Female 5xFAD Mice, and Reduces β-Amyloid Load in Males and Females.
Cells
Pan AL,Audrain M,Sakakibara E,Joshi R,Zhu X,Wang Q,Wang M,Beckmann ND,Schadt EE,Gandy S,Zhang B,Ehrlich ME,Salton SR
MN1000 was used in ELISA, Immunohistochemistry- Free Floating, Immunohistochemistry (Paraffin), Western Blot to suggest that that gender-specific interventions may be indicated in the treatment of Alzheimer’s disease.
Thu Dec 01 00:00:00 EST 2022
UPRmt activation improves pathological alterations in cellular models of mitochondrial diseases.
Orphanet journal of rare diseases
Suárez-Rivero JM,Pastor-Maldonado CJ,Povea-Cabello S,Álvarez-Córdoba M,Villalón-García I,Talaverón-Rey M,Suárez-Carrillo A,Munuera-Cabeza M,Reche-López D,Cilleros-Holgado P,Piñero-Perez R,Sánchez-Alcázar JA
MN1000 was used in Immunocytochemistry-immunoflourescence to provide compelling evidence to propose the activation of intrinsic cellular compensatory mechanisms as promising therapeutic strategy for mitochondrial diseases.
Tue May 17 00:00:00 EDT 2022
Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome.
Cell
Bourdenx M,Martín-Segura A,Scrivo A,Rodriguez-Navarro JA,Kaushik S,Tasset I,Diaz A,Storm NJ,Xin Q,Juste YR,Stevenson E,Luengo E,Clement CC,Choi SJ,Krogan NJ,Mosharov EV,Santambrogio L,Grueninger F,Collin L,Swaney DL,Sulzer D,Gavathiotis E,Cuervo AM
MN1000 was used in Enzyme-linked immunosorbent assay to conclude that functional CMA is essential for neuronal proteostasis through the maintenance of a subset of the proteome with a higher risk of misfolding than the general proteome.
Thu May 13 00:00:00 EDT 2021
Fluc-EGFP reporter mice reveal differential alterations of neuronal proteostasis in aging and disease.
The EMBO journal
Blumenstock S,Schulz-Trieglaff EK,Voelkl K,Bolender AL,Lapios P,Lindner J,Hipp MS,Hartl FU,Klein R,Dudanova I
MN1000 was used in Immunohistochemistry-immunofluorescence to develope reporter mice for in vivo analysis of neuronal proteostasis.
Fri Oct 01 00:00:00 EDT 2021
Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer's disease-like pathology in human cerebral organoids.
Molecular psychiatry
Pérez MJ,Ivanyuk D,Panagiotakopoulou V,Di Napoli G,Kalb S,Brunetti D,Al-Shaana R,Kaeser SA,Fraschka SA,Jucker M,Zeviani M,Viscomi C,Deleidi M
MN1000 was used in Western Blotting to support a mechanistic link between mitochondrial function and common neurodegenerative proteinopathies.
Fri Oct 01 00:00:00 EDT 2021
Gestational high fat diet protects 3xTg offspring from memory impairments, synaptic dysfunction, and brain pathology.
Molecular psychiatry
Di Meco A,Jelinek J,Lauretti E,Curtis ME,Issa JJ,Praticò D
MN1000 was used in Immunohistochemistry to investigate if gestational high fat diet protects offspring against the development of the Alzheimer''s disease phenotype.
Mon Nov 01 00:00:00 EDT 2021
Gestational high fat diet protects 3xTg offspring from memory impairments, synaptic dysfunction, and brain pathology.
Molecular psychiatry
Di Meco A,Jelinek J,Lauretti E,Curtis ME,Issa JJ,Praticò D
MN1000 was used in Immunohistochemistry to investigate if gestational high fat diet protects offspring against the development of the Alzheimer''s disease phenotype.
Mon Nov 01 00:00:00 EDT 2021
Grafts Derived from an α-Synuclein Triplication Patient Mediate Functional Recovery but Develop Disease-Associated Pathology in the 6-OHDA Model of Parkinson's Disease.
Journal of Parkinson's disease
Shrigley S,Nilsson F,Mattsson B,Fiorenzano A,Mudannayake J,Bruzelius A,Ottosson DR,Björklund A,Hoban DB,Parmar M
MN1000 was used in Immunocytochemistry to assess the viability and function of dopaminergic neuron grafts derived from a patient hiPSC line with an α-synuclein gene triplication using a clinical grade human embryonic stem cell line as a reference control.
Mon Dec 06 00:00:00 EST 2021
Partial Inhibition of Mitochondrial Complex I Reduces Tau Pathology and Improves Energy Homeostasis and Synaptic Function in 3xTg-AD Mice.
Journal of Alzheimer's disease : JAD
Stojakovic A,Chang SY,Nesbitt J,Pichurin NP,Ostroot MA,Aikawa T,Kanekiyo T,Trushina E
MN1000 was used in Western Blotting to investigate the effect of specific MCI inhibitor tricyclic pyrone compound CP2 on levels of human pTau, memory function, long term potentiation (LTP), and energy homeostasis in 18-month-old 3xTg-AD mice and explore the potential mechanisms.
Mon Sep 27 00:00:00 EDT 2021
Development of a fully human assay combining NGN2-inducible neurons co-cultured with iPSC-derived astrocytes amenable for electrophysiological studies.
Stem cell research
Shih PY,Kreir M,Kumar D,Seibt F,Pestana F,Schmid B,Holst B,Clausen C,Steeg R,Fischer B,Pita-Almenar J,Ebneth A,Cabrera-Socorro A
MN1000 was used in Immunocytochemistry to demonstrate that hiPSC-derived astrocytes and neurons can be co-cultured and display functional properties comparable to the gold standard used in electrophysiology.
Thu Jul 01 00:00:00 EDT 2021
Lactobacillus plantarum PS128 prevents cognitive dysfunction in Alzheimer's disease mice by modulating propionic acid levels, glycogen synthase kinase 3 beta activity, and gliosis.
BMC complementary medicine and therapies
Huang HJ,Chen JL,Liao JF,Chen YH,Chieu MW,Ke YY,Hsu CC,Tsai YC,Hsieh-Li HM
MN1000 was used in Western Blotting to evaluate the beneficial effects of PS128 and to further elucidate its mechanism in Alzheimer''s disease mice.
Sat Oct 09 00:00:00 EDT 2021
Amyloid and Tau Induce Cell Death Independently of TSPO Polymerization and Density Changes.
ACS omega
Tournier BB,Ceyzériat K,Bouteldja FN,Millet P
MN1000 was used in ELISA, Immunohistochemistry - Free Floating, Immunohistochemistry (Paraffin), Western Blot to determine the effects of Aβ, Tau, and TSPO antagonists on proliferation/cell death and TSPO polymerization in the C6 astrocytic cell line.
Tue Jul 27 00:00:00 EDT 2021
Medial septum tau accumulation induces spatial memory deficit via disrupting medial septum-hippocampus cholinergic pathway.
Clinical and translational medicine
Wu D,Gao D,Yu H,Pi G,Xiong R,Lei H,Wang X,Liu E,Ye J,Yu H,Gao Y,He T,Jiang T,Sun F,Su J,Song G,Peng W,Yang Y,Wang JZ
MN1000 was used in Western Blot to observe an aberrant tau accumulation in the medial septum (MS) of 3xTg and 5xFAD mice, especially in their cholinergic neurons.
Tue Jun 01 00:00:00 EDT 2021
Novelty-like activation of locus coeruleus protects against deleterious human pretangle tau effects while stress-inducing activation worsens its effects.
Alzheimer's & dementia (New York, N. Y.)
Omoluabi T,Torraville SE,Maziar A,Ghosh A,Power KD,Reinhardt C,Harley CW,Yuan Q
MN1000 was used in Immunohistochemistry to argue that variations in environmental experiences associated with differing LC activity patterns may account for individual susceptibility to development of AD in humans.
Tue Jan 11 00:00:00 EST 2022
Wolframin-1-expressing neurons in the entorhinal cortex propagate tau to CA1 neurons and impair hippocampal memory in mice.
Science translational medicine
Delpech JC,Pathak D,Varghese M,Kalavai SV,Hays EC,Hof PR,Johnson WE,Ikezu S,Medalla M,Luebke JI,Ikezu T
MN1000 was used in Immunohistochemistry (Frozen) to demonstrate tau transfer from the ECII to CA1 in mouse brain and provides an early Braak stage preclinical model of AD.
Wed Sep 15 00:00:00 EDT 2021
Wolframin-1-expressing neurons in the entorhinal cortex propagate tau to CA1 neurons and impair hippocampal memory in mice.
Science translational medicine
Delpech JC,Pathak D,Varghese M,Kalavai SV,Hays EC,Hof PR,Johnson WE,Ikezu S,Medalla M,Luebke JI,Ikezu T
MN1000 was used in Immunohistochemistry (Frozen) to demonstrate tau transfer from the ECII to CA1 in mouse brain and provides an early Braak stage preclinical model of AD.
Wed Sep 15 00:00:00 EDT 2021
Rutin prevents tau pathology and neuroinflammation in a mouse model of Alzheimer's disease.
Journal of neuroinflammation
Sun XY,Li LJ,Dong QX,Zhu J,Huang YR,Hou SJ,Yu XL,Liu RT
MN1000 was used in Immunocytochemistry to show that in combination with the previously reported therapeutic effects of rutin on Aβ pathology, rutin is a promising drug candidate for AD treatment based its combinatorial targeting of tau and Aβ.
Fri Jun 11 00:00:00 EDT 2021
Spreading of Alzheimer tau seeds is enhanced by aging and template matching with limited impact of amyloid-β.
The Journal of biological chemistry
Nies SH,Takahashi H,Herber CS,Huttner A,Chase A,Strittmatter SM
MN1000 was used in Western Blot to assesses the impact of Aβ copathology, of deleting loci known to modify Alzheimer's disease risk (Ptk2b, Grn, and Tmem106b) and of pharmacological intervention with an Fyn kinase inhibitor on tau spreading after injection of AD tau extracts.
Fri Oct 01 00:00:00 EDT 2021
Structural mapping techniques distinguish the surfaces of fibrillar 1N3R and 1N4R human tau.
The Journal of biological chemistry
Caroux E,Redeker V,Madiona K,Melki R
MN1000 was used in Western Blot to open new perspectives for the design of highly specific ligands with diagnostic and therapeutic potential.
Mon Nov 01 00:00:00 EDT 2021
Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue.
Acta neuropathologica communications
Miller LVC,Mukadam AS,Durrant CS,Vaysburd MJ,Katsinelos T,Tuck BJ,Sanford S,Sheppard O,Knox C,Cheng S,James LC,Coleman MP,McEwan WA
MN1000 was used in Western Blot, Immunohistochemistry (PFA fixed) to ask whether tau assemblies share with classical pathogens the characteristic of particulate behaviour.
Fri Mar 12 00:00:00 EST 2021
Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue.
Acta neuropathologica communications
Miller LVC,Mukadam AS,Durrant CS,Vaysburd MJ,Katsinelos T,Tuck BJ,Sanford S,Sheppard O,Knox C,Cheng S,James LC,Coleman MP,McEwan WA
MN1000 was used in Western Blot, Immunohistochemistry (PFA fixed) to ask whether tau assemblies share with classical pathogens the characteristic of particulate behaviour.
Fri Mar 12 00:00:00 EST 2021
Reduction of pTau and APP levels in mammalian brain after low-dose radiation.
Scientific reports
Iacono D,Murphy EK,Avantsa SS,Perl DP,Day RM
MN1000 was used in Western Blot, Immunohistochemistry (Paraffin) to analyse possible molecular and neuropathology changes of phosphorylated-Tau (pTau), all-Tau forms, β-tubulin, amyloid precursor protein (APP), glial fibrillary acidic protein (GFAP), ionized calcium binding adaptor molecule 1 (IBA-1), myelin basic protein (MBP), and GAP43 in Frontal Cortex (FC), Hippocampus (H) and Cerebellum (CRB) of swine brains following total-body low-dose radiation (1.79 Gy).
Tue Jan 26 00:00:00 EST 2021
Reduction of pTau and APP levels in mammalian brain after low-dose radiation.
Scientific reports
Iacono D,Murphy EK,Avantsa SS,Perl DP,Day RM
MN1000 was used in Western Blot, Immunohistochemistry (Paraffin) to analyse possible molecular and neuropathology changes of phosphorylated-Tau (pTau), all-Tau forms, β-tubulin, amyloid precursor protein (APP), glial fibrillary acidic protein (GFAP), ionized calcium binding adaptor molecule 1 (IBA-1), myelin basic protein (MBP), and GAP43 in Frontal Cortex (FC), Hippocampus (H) and Cerebellum (CRB) of swine brains following total-body low-dose radiation (1.79 Gy).
Tue Jan 26 00:00:00 EST 2021
SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer's disease.
Molecular neurodegeneration
Bichmann M,Prat Oriol N,Ercan-Herbst E,Schöndorf DC,Gomez Ramos B,Schwärzler V,Neu M,Schlüter A,Wang X,Jin L,Hu C,Tian Y,Ried JS,Haberkant P,Gasparini L,Ehrnhoefer DE
MN1000 was used in Immunoprecipitation to demonstrate that methylated Tau levels increase with Tau pathology stage in human AD samples as well as in a mouse model of Tauopathy.
Fri Jul 02 00:00:00 EDT 2021
SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer's disease.
Molecular neurodegeneration
Bichmann M,Prat Oriol N,Ercan-Herbst E,Schöndorf DC,Gomez Ramos B,Schwärzler V,Neu M,Schlüter A,Wang X,Jin L,Hu C,Tian Y,Ried JS,Haberkant P,Gasparini L,Ehrnhoefer DE
MN1000 was used in Immunoprecipitation to demonstrate that methylated Tau levels increase with Tau pathology stage in human AD samples as well as in a mouse model of Tauopathy.
Fri Jul 02 00:00:00 EDT 2021
Netrin-1 receptor UNC5C cleavage by active δ-secretase enhances neurodegeneration, promoting Alzheimer's disease pathologies.
Science advances
Chen G,Kang SS,Wang Z,Ahn EH,Xia Y,Liu X,Sandoval IM,Manfredsson FP,Zhang Z,Ye K
MN1000 was used in Western Blot to report that netrin-1 reduction in Alzheimer's disease brains triggers delta-secretase activation, which subsequently cleaves UNC5C receptor on N467 and N547 residues, augmenting caspase-3 activities and neuronal apoptosis.
Thu Apr 01 00:00:00 EDT 2021
Dysregulation of the Retromer Complex in Brain Endothelial Cells Results in Accumulation of Phosphorylated Tau.
Journal of inflammation research
Filippone A,Smith T,Pratico D
MN1000 was used in Western Blot to demonstrate that in brain endothelial cells retromer complex dysfunction by influencing endosome-lysosome degradation pathways results in altered proteostasis.
Sat Jul 16 00:00:00 EDT 2022
Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model.
Molecular neurodegeneration
Clayton K,Delpech JC,Herron S,Iwahara N,Ericsson M,Saito T,Saido TC,Ikezu S,Ikezu T
MN1000 was used in Immunohistochemistry (PFA fixed) to test the effect of microglia depletion in C57BL/6 (WT) and humanized APP mutant knock-in homozygote (AppNL-G-F) mice.
Mon Mar 22 00:00:00 EDT 2021
Tau N-Terminal Inserts Regulate Tau Liquid-Liquid Phase Separation and Condensates Maturation in a Neuronal Cell Model.
International journal of molecular sciences
Wu C,Zhao J,Wu Q,Tan Q,Liu Q,Xiao S
MN1000 was used in Western Blotting to observe the dynamics of three tau isoforms with different N-terminal inserts in live neuronal cell line HT22.
Wed Sep 08 00:00:00 EDT 2021
Systematic Phenotyping and Characterization of the 3xTg-AD Mouse Model of Alzheimer's Disease.
Frontiers in neuroscience
Javonillo DI,Tran KM,Phan J,Hingco E,Kramár EA,da Cunha C,Forner S,Kawauchi S,Milinkeviciute G,Gomez-Arboledas A,Neumann J,Banh CE,Huynh M,Matheos DP,Rezaie N,Alcantara JA,Mortazavi A,Wood MA,Tenner AJ,MacGregor GR,Green KN,LaFerla FM
MN1000 was used in Immunohistochemistry to demonstrate the utility of a characterization pipeline that generates robust and standardized information relevant to investigating and comparing disease etiologies of current and future models of AD.
Sat Dec 17 00:00:00 EST 2022
Antibody Protection against Long-Term Memory Loss Induced by Monomeric C-Reactive Protein in a Mouse Model of Dementia.
Biomedicines
García-Lara E,Aguirre S,Clotet N,Sawkulycz X,Bartra C,Almenara-Fuentes L,Suñol C,Corpas R,Olah P,Tripon F,Crauciuc A,Slevin M,Sanfeliu C
MN1000 was used in Western Blotting to investigate if a single hippocampal administration of monomeric C-reactive protein in mice induces memory loss.
Fri Jul 16 00:00:00 EDT 2021
4-Repeat tau seeds and templating subtypes as brain and CSF biomarkers of frontotemporal lobar degeneration.
Acta neuropathologica
Saijo E,Metrick MA,Koga S,Parchi P,Litvan I,Spina S,Boxer A,Rojas JC,Galasko D,Kraus A,Rossi M,Newell K,Zanusso G,Grinberg LT,Seeley WW,Ghetti B,Dickson DW,Caughey B
MN1000 was used in Immunoprecipitation to investigate potential new biomarkers of tauopathies through the use of an ultrasensitive tau seed amplification assay (4R RT-QuIC) for the 4-repeat (4R) tau aggregates of progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and other diseases with 4R tauopathy.
Wed Jan 01 00:00:00 EST 2020
Full recovery of the Alzheimer's disease phenotype by gain of function of vacuolar protein sorting 35.
Molecular psychiatry
Li JG,Chiu J,Praticò D
MN1000 was used in Western Blotting to demonstrate that VPS35 is directly involved in the development of Alzheimer's disease-like phenotype.
Thu Oct 01 00:00:00 EDT 2020
Full recovery of the Alzheimer's disease phenotype by gain of function of vacuolar protein sorting 35.
Molecular psychiatry
Li JG,Chiu J,Praticò D
MN1000 was used in Western Blotting to demonstrate that VPS35 is directly involved in the development of Alzheimer's disease-like phenotype.
Thu Oct 01 00:00:00 EDT 2020
Tau-induced upregulation of C/EBPβ-TRPC1-SOCE signaling aggravates tauopathies: A vicious cycle in Alzheimer neurodegeneration.
Aging cell
Ye J,Yin Y,Yin Y,Zhang H,Wan H,Wang L,Zuo Y,Gao D,Li M,Li J,Liu Y,Ke D,Wang JZ
MN1000 was used in Western Blotting to show that increasing intracellular tau could upregulate mRNA and protein levels of TRPC1 (transient receptor potential channel 1) with an activated store-operated calcium entry (SOCE), an increased intraneuronal steady-state [Ca2+ ]i , an enhanced endoplasmic reticulum (ER) stress, an imbalanced protein kinases and phosphatase, and an aggravated tauopathy.
Tue Sep 01 00:00:00 EDT 2020
Tau inhibits PKA by nuclear proteasome-dependent PKAR2α elevation with suppressed CREB/GluA1 phosphorylation.
Aging cell
Ye J,Yin Y,Liu H,Fang L,Tao X,Wei L,Zuo Y,Yin Y,Ke D,Wang JZ
MN1000 was used in Western Blot to reveal that intracellular tau accumulation induces synapse and memory impairments by inhibiting PKA/CREB/BDNF/TrkB and PKA/GluA1 signaling, and deficit of PA28γ-20S proteasome complex formation contributes to PKAR2α elevation and PKA inhibition.
Wed Jan 01 00:00:00 EST 2020
Selective Disruption of Inhibitory Synapses Leading to Neuronal Hyperexcitability at an Early Stage of Tau Pathogenesis in a Mouse Model.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Shimojo M,Takuwa H,Takado Y,Tokunaga M,Tsukamoto S,Minatohara K,Ono M,Seki C,Maeda J,Urushihata T,Minamihisamatsu T,Aoki I,Kawamura K,Zhang MR,Suhara T,Sahara N,Higuchi M
MN1000 was used in Immunohistochemistry to indicate that selective degeneration of inhibitory synapse with hyperexcitability in the cortical circuit constitutes the critical early pathophysiology of tauopathy in mice.
Wed Apr 22 00:00:00 EDT 2020
Development and Validation of a High Sensitivity Assay for Measuring p217 + tau in Cerebrospinal Fluid.
Journal of Alzheimer's disease : JAD
Triana-Baltzer G,Van Kolen K,Theunis C,Moughadam S,Slemmon R,Mercken M,Galpern W,Sun H,Kolb H
MN1000 was used in an ELISA assay to describe the development and validation of a novel sELISA for measuring CSF tau species containing phosphorylation at threonines 212 & 217, aka p217 + tau, using the PT3 antibody.
Fri Sep 10 00:00:00 EDT 2021
Peripheral inflammation promotes brain tau transmission via disrupting blood-brain barrier.
Bioscience reports
Liu Y,Zhang S,Li X,Liu E,Wang X,Zhou Q,Ye J,Wang JZ
MN1000 was used in Immunohistochemistry (PFA fixed) to study the role and mechanisms underlying periphery inflammation on brain tau transmission.
Fri Feb 28 00:00:00 EST 2020
Early-Onset Dementia in War Veterans: Brain Polypathology and Clinicopathologic Complexity.
Journal of neuropathology and experimental neurology
Iacono D,Lee P,Edlow BL,Gray N,Fischl B,Kenney K,Lew HL,Lozanoff S,Liacouras P,Lichtenberger J,Dams-O'Connor K,Cifu D,Hinds SR,Perl DP
MN1000 was used in Immunohistochemistry to describe clinicopathologic findings in 4 military veterans with early-onset dementia (EOD) who had varying histories of blunt- and blast-TBI, cognitive decline, behavioral abnormalities, post-traumatic stress disorder, suicidal ideation, and suicide.
Sat Feb 01 00:00:00 EST 2020
Increased Tau Expression Correlates With IDH Mutation in Infiltrating Gliomas and Impairs Cell Migration.
Journal of neuropathology and experimental neurology
Nakata S,Price A,Eberhart C,Morris M
MN1000 was used in Immunohistochemistry (Paraffin) to show that high tau mRNA expression is associated with improved patient survival in infiltrating gliomas.
Fri May 01 00:00:00 EDT 2020
Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species.
The Journal of biological chemistry
Nachman E,Wentink AS,Madiona K,Bousset L,Katsinelos T,Allinson K,Kampinga H,McEwan WA,Jahn TR,Melki R,Mogk A,Bukau B,Nussbaum-Krammer C
MN1000 was used in Dot blot to show that an ATP-dependent human chaperone system disassembles Tau fibrils in vitro We found that this function is mediated by the core chaperone HSC70, assisted by specific cochaperones, in particular class B J-domain proteins and a heat shock protein 110 (Hsp110)-type nucleotide exchange factor (NEF).
Fri Jul 10 00:00:00 EDT 2020
Both Amyloid-β Peptide and Tau Protein Are Affected by an Anti-Amyloid-β Antibody Fragment in Elderly 3xTg-AD Mice.
International journal of molecular sciences
Roda AR,Montoliu-Gaya L,Serra-Mir G,Villegas S
MN1000 was used in Immunohistochemistry to assess the effects of scFv-h3D6 on Aβ and tau pathologies in 22-month-old 3xTg-AD mice. Briefly, 3xTg-AD female mice were treated for 2 weeks with scFv-h3D6 and compared with 3xTg-AD and non-transgenic (NTg) mice treated with PBS..
Thu Sep 10 00:00:00 EDT 2020
Altered Expression of the m6A Methyltransferase METTL3 in Alzheimer's Disease.
eNeuro
Huang H,Camats-Perna J,Medeiros R,Anggono V,Widagdo J
MN1000 was used in Western Blotting to investigate the expression profile of known N6-methyladenosine(m6A)-regulatory genes using a public RNA-seq dataset and identified a subset of genes which were significantly dysregulated in the human Alzheimer's disease(AD) brain.
Fri Jun 18 00:00:00 EDT 2021
Fyn Kinase Controls Tau Aggregation In Vivo.
Cell reports
Briner A,Götz J,Polanco JC
MN1000 was used in Western Blot to identify Fyn as a key regulator of tau pathology independently of Aβ-induced toxicity.
Tue Aug 18 00:00:00 EDT 2020
Tau reduction in aged mice does not impact Microangiopathy.
Acta neuropathologica communications
Bennett RE,Hu M,Fernandes A,Perez-Rando M,Robbins A,Kamath T,Dujardin S,Hyman BT
MN1000 was used in Immunocytochemistry-immunoflourescence to understand the nature of tau-related microangiopathy in human AD and in tau mice and examine whether this soluble tau is directly responsible for the microangiopathic changes.
Tue Aug 18 00:00:00 EDT 2020
Increased Tau Expression Correlates with Neuronal Maturation in the Developing Human Cerebral Cortex.
eNeuro
Fiock KL,Smalley ME,Crary JF,Pasca AM,Hefti MM
MN1000 was used in Immunohistochemistry to demonstrate that tau increases with neuronal maturation in both the developing fetal brain and iPSC-derived organoids.
Fri Jun 18 00:00:00 EDT 2021
Delta-secretase triggers Alzheimer's disease pathologies in wild-type hAPP/hMAPT double transgenic mice.
Cell death & disease
Wu Z,Liu X,Cheng L,Ye K
MN1000 was used in Western Blot to establish a new mouse Alzheimer's disease model with both human wild-type amyloid-β precursor protein and Tau.
Sat Dec 12 00:00:00 EST 2020
A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles.
Molecular neurodegeneration
Li JG,Chiu J,Ramanjulu M,Blass BE,Praticò D
MN1000 was used in Western Blot to demonstrate that vacuolar protein sorting 35 genetic manipulation modulates the phenotype of mouse models of Alzheimer's disease.
Wed Jan 22 00:00:00 EST 2020
A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles.
Molecular neurodegeneration
Li JG,Chiu J,Ramanjulu M,Blass BE,Praticò D
MN1000 was used in Western Blot to demonstrate that vacuolar protein sorting 35 genetic manipulation modulates the phenotype of mouse models of Alzheimer's disease.
Wed Jan 22 00:00:00 EST 2020
Cognitive Impairment in the 3xTg-AD Mouse Model of Alzheimer's Disease is Affected by Aβ-ImmunoTherapy and Cognitive Stimulation.
Pharmaceutics
Roda AR,Esquerda-Canals G,Martí-Clúa J,Villegas S
MN1000 was used in Immunohistochemistry (Paraffin) to test the effect of chronic Aβ-immunotherapy on behavioral and cognitive abilities by monthly administering the antibody fragment scFv-h3D6 to 3xTg-AD female mice from 5 to 9 months of age.
Fri Oct 02 00:00:00 EDT 2020
Heavy metals contaminating the environment of a progressive supranuclear palsy cluster induce tau accumulation and cell death in cultured neurons.
Scientific reports
Alquezar C,Felix JB,McCandlish E,Buckley BT,Caparros-Lefebvre D,Karch CM,Golbe LI,Kao AW
MN1000 was used in Western Blotting to investigate the potential neurotoxic effects of heavy metals enriched in a highly industrialised region in France with a cluster of sporadic progressive supranuclear palsy cases.
Fri Jan 17 00:00:00 EST 2020
The behavioural and neuropathologic sexual dimorphism and absence of MIP-3α in tau P301S mouse model of Alzheimer's disease.
Journal of neuroinflammation
Sun Y,Guo Y,Feng X,Jia M,Ai N,Dong Y,Zheng Y,Fu L,Yu B,Zhang H,Wu J,Yu X,Wu H,Kong W
MN1000 was used in Western Blotting to develop numerous transgenic mouse models that recapitulate critical AD-like pathology to elucidate the pathogenic mechanisms underlying AD and evaluate therapeutic approaches targeting tau.
Mon Feb 24 00:00:00 EST 2020
Tau affects P53 function and cell fate during the DNA damage response.
Communications biology
Sola M,Magrin C,Pedrioli G,Pinton S,Salvadè A,Papin S,Paganetti P
MN1000 was used in Immunoprecipitation to show that altered P53 stability and activity result in reduced cell death and increased cell senescence.
Tue May 19 00:00:00 EDT 2020
Explosive-driven double-blast exposure: molecular, histopathological, and behavioral consequences.
Scientific reports
Murphy EK,Iacono D,Pan H,Grimes JB,Parks S,Raiciulescu S,Leonessa F,Perl DP
MN1000 was used in Western Blotting to identify molecular, histopathological, and behavioral changes in rats 2 weeks after explosive-driven double-blast exposure.
Thu Oct 15 00:00:00 EDT 2020
Fyn kinase inhibition reduces protein aggregation, increases synapse density and improves memory in transgenic and traumatic Tauopathy.
Acta neuropathologica communications
Tang SJ,Fesharaki-Zadeh A,Takahashi H,Nies SH,Smith LM,Luo A,Chyung A,Chiasseu M,Strittmatter SM
MN1000 was used in Immunohistochemistry to discover whether pharmacological Fyn inhibition alters Tauopathy.
Wed Jul 01 00:00:00 EDT 2020
IPSC-Derived Neuronal Cultures Carrying the Alzheimer's Disease Associated TREM2 R47H Variant Enables the Construction of an Aβ-Induced Gene Regulatory Network.
International journal of molecular sciences
Martins S,Müller-Schiffmann A,Erichsen L,Bohndorf M,Wruck W,Sleegers K,Van Broeckhoven C,Korth C,Adjaye J
MN1000 was used in Western Blotting to study the molecular mechanisms underlying the etiology of late-onset Alzheimer´s disease (LOAD).
Thu Jun 25 00:00:00 EDT 2020
Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization.
Scientific reports
Dominguez-Meijide A,Vasili E,König A,Cima-Omori MS,Ibáñez de Opakua A,Leonov A,Ryazanov S,Zweckstetter M,Griesinger C,Outeiro TF
MN1000 was used in an ELISA assay to assess the effects of different pharmacological interventions on the aggregation and internalization of tau and aSyn.
Thu Jul 30 00:00:00 EDT 2020
Differential compartmental processing and phosphorylation of pathogenic human tau and native mouse tau in the line 66 model of frontotemporal dementia.
The Journal of biological chemistry
Lemke N,Melis V,Lauer D,Magbagbeolu M,Neumann B,Harrington CR,Riedel G,Wischik CM,Theuring F,Schwab K
MN1000 was used in Western Blot, Immunohistochemistry to examine the cellular distribution of tau protein species in human tau overexpressing line 66 mice, a transgenic mouse model akin to genetic variants of frontotemporal dementia.
Fri Dec 25 00:00:00 EST 2020
Differential compartmental processing and phosphorylation of pathogenic human tau and native mouse tau in the line 66 model of frontotemporal dementia.
The Journal of biological chemistry
Lemke N,Melis V,Lauer D,Magbagbeolu M,Neumann B,Harrington CR,Riedel G,Wischik CM,Theuring F,Schwab K
MN1000 was used in Western Blot, Immunohistochemistry to examine the cellular distribution of tau protein species in human tau overexpressing line 66 mice, a transgenic mouse model akin to genetic variants of frontotemporal dementia.
Fri Dec 25 00:00:00 EST 2020
Modulating disease-relevant tau oligomeric strains by small molecules.
The Journal of biological chemistry
Lo Cascio F,Garcia S,Montalbano M,Puangmalai N,McAllen S,Pace A,Palumbo Piccionello A,Kayed R
MN1000 was used in Immunocytochemistry to show the compound CL3 may aid tau imaging for detection of tau oligomeric strains and diagnosis of tauopathies.
Fri Oct 30 00:00:00 EDT 2020
Tumour necrosis factor induces increased production of extracellular amyloid-β- and α-synuclein-containing aggregates by human Alzheimer's disease neurons.
Brain communications
Whiten DR,Brownjohn PW,Moore S,De S,Strano A,Zuo Y,Haneklaus M,Klenerman D,Livesey FJ
MN1000 was used in Functional assay to report that exposure of Alzheimer's disease neurons, but not neurons, to tumour necrosis factor induces substantial production of extracellular protein aggregates.
Sat Jan 29 00:00:00 EST 2022
CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived Neurons.
Neuron
Tian R,Gachechiladze MA,Ludwig CH,Laurie MT,Hong JY,Nathaniel D,Prabhu AV,Fernandopulle MS,Patel R,Abshari M,Ward ME,Kampmann M
MN1000 was used in Western Blot to describe a CRISPR interference (CRISPRi)-based platform for genetic screens in human neurons derived from induced pluripotent stem cells (iPSCs).
Wed Oct 23 00:00:00 EDT 2019
Seeding selectivity and ultrasensitive detection of tau aggregate conformers of Alzheimer disease.
Acta neuropathologica
Kraus A,Saijo E,Metrick MA,Newell K,Sigurdson CJ,Zanusso G,Ghetti B,Caughey B
MN1000 was used in Immunoprecipitation to study the molecular basis for Alzheimer's disease's tau filament propagation and to improve detection of tau aggregates as potential biomarkers.
Mon Apr 01 00:00:00 EDT 2019
Decreased synthesis of ribosomal proteins in tauopathy revealed by non-canonical amino acid labelling.
The EMBO journal
Evans HT,Benetatos J,van Roijen M,Bodea LG,Götz J
MN1000 was used in Immunohistochemistry - Free Floating to present a potential pathomechanism by which pathological tau interferes with cellular functions through the dysregulation of ribosomal protein synthesis.
Mon Jul 01 00:00:00 EDT 2019
Brains of rhesus monkeys display Aβ deposits and glial pathology while lacking Aβ dimers and other Alzheimer's pathologies.
Aging cell
Zhang J,Chen B,Lu J,Wu Y,Wang S,Yao Z,Zhu L,Qiao Y,Sun Q,Qin W,Zhao Q,Jia J,Wei C
MN1000 was used in Western Blotting to indicate that the cerebral amyloid beta dimer plats an important role in Alzheimer's disease pathogenesis, so targeting this dimer is a promising strategy for preventing this disease.
Thu Aug 01 00:00:00 EDT 2019
Tau/MAPT disease-associated variant A152T alters tau function and toxicity via impaired retrograde axonal transport.
Human molecular genetics
Butler VJ,Salazar DA,Soriano-Castell D,Alves-Ferreira M,Dennissen FJA,Vohra M,Oses-Prieto JA,Li KH,Wang AL,Jing B,Li B,Groisman A,Gutierrez E,Mooney S,Burlingame AL,Ashrafi K,Mandelkow EM,Encalada SE,Kao AW
MN1000 was used in Immunoprecipitation to examine the role of phosphorylation of the variant threonine in A152T tau toxicity, and study the mechanism by which these effects are mediated.
Wed May 01 00:00:00 EDT 2019
Repetitive Concussive and Subconcussive Injury in a Human Tau Mouse Model Results in Chronic Cognitive Dysfunction and Disruption of White Matter Tracts, But Not Tau Pathology.
Journal of neurotrauma
Gangolli M,Benetatos J,Esparza TJ,Fountain EM,Seneviratne S,Brody DL
MN1000 was used in Immunohistochemistry to determine the effect of repetitive brain trauma in adult mice and observe changes in tau tangle accumulation.
Fri Mar 01 00:00:00 EST 2019
Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells.
PloS one
Chadchankar J,Korboukh V,Conway LC,Wobst HJ,Walker CA,Doig P,Jacobsen SJ,Brandon NJ,Moss SJ,Wang Q
MN1000 was used in Western Blotting to study the effects of USP14 inhibition in mammalian cells using small molecule inhibitors and an inactive USP14 mutant C114A.
Mon Mar 23 00:00:00 EDT 2020
Tau protein aggregates inhibit the protein-folding and vesicular trafficking arms of the cellular proteostasis network.
The Journal of biological chemistry
Yu A,Fox SG,Cavallini A,Kerridge C,O'Neill MJ,Wolak J,Bose S,Morimoto RI
MN1000 was used in Immunocytochemistry-immunoflourescence to investigate if the molecular chaperones heat-shock cognate 71-kDa protein (HSC70)/heat-shock protein 70 (HSP70), HSP90, and J-domain co-chaperones are sequestered by tau aggregates.
Fri May 10 00:00:00 EDT 2019
Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer's disease.
Nature communications
Jadiya P,Kolmetzky DW,Tomar D,Di Meco A,Lombardi AA,Lambert JP,Luongo TS,Ludtmann MH,Praticò D,Elrod JW
MN1000 was used in Western Blotting to provide a link between the calcium dysregulation and metabolic dysfunction hypotheses of Alzheimer's disease (AD) and suggest mCa2+ exchange as potential therapeutic target in AD.
Thu Aug 29 00:00:00 EDT 2019
Introduction of Tau Oligomers into Cortical Neurons Alters Action Potential Dynamics and Disrupts Synaptic Transmission and Plasticity.
eNeuro
Hill E,Karikari TK,Moffat KG,Richardson MJE,Wall MJ
MN1000 was used in Dot blot to provide detailed characterization of the concentration and time-dependent actions of tau oligomers on neuronal properties, and show that tau interferes with the action potential wave form, modifies synaptic transmission and can block events that probably underlie memory storage.
Fri May 08 00:00:00 EDT 2020
Microtubules Deform the Nuclear Membrane and Disrupt Nucleocytoplasmic Transport in Tau-Mediated Frontotemporal Dementia.
Cell reports
Paonessa F,Evans LD,Solanki R,Larrieu D,Wray S,Hardy J,Jackson SP,Livesey FJ
MN1000 was used in Western Blotting to study the underlying pathogenic mechanisms in inherited frontotemporal dementia.
Tue Jan 15 00:00:00 EST 2019
Therapeutic antibody targeting microtubule-binding domain prevents neuronal internalization of extracellular tau via masking neuron surface proteoglycans.
Acta neuropathologica communications
Weisová P,Cehlár O,Škrabana R,Žilková M,Filipčík P,Kováčech B,Prčina M,Wojčiaková Ľ,Fialová Ľ,Smolek T,Kontseková E,Žilka N,Novák M
MN1000 was used in Immunocytochemistry to show that DC8E8 antibody acts via extracellular mechanism and does not influence viability and physiological functions of neurons.
Wed Aug 07 00:00:00 EDT 2019
An experimental model of Braak's pretangle proposal for the origin of Alzheimer's disease: the role of locus coeruleus in early symptom development.
Alzheimer's research & therapy
Ghosh A,Torraville SE,Mukherjee B,Walling SG,Martin GM,Harley CW,Yuan Q
MN1000 was used in Immunohistochemistry-immunofluorescence to investigate the hypothesis that LC pretangles generate preclinical Alzheimer pathology.
Wed Jul 03 00:00:00 EDT 2019
Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline.
Nature
Bussian TJ,Aziz A,Meyer CF,Swenson BL,van Deursen JM,Baker DJ
MN1000 was used in Western Blotting to study the role of senescent cells in the aetiology of tau-dependent pathologies.
Mon Oct 01 00:00:00 EDT 2018
Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease.
Neuron
Eftekharzadeh B,Daigle JG,Kapinos LE,Coyne A,Schiantarelli J,Carlomagno Y,Cook C,Miller SJ,Dujardin S,Amaral AS,Grima JC,Bennett RE,Tepper K,DeTure M,Vanderburg CR,Corjuc BT,DeVos SL,Gonzalez JA,Chew J,Vidensky S,Gage FH,Mertens J,Troncoso J,Mandelkow E,Salvatella X,Lim RYH,Petrucelli L,Wegmann S,Rothstein JD,Hyman BT
MN1000 was used in ELISA, Immunohistochemistry- Free Floating, Immunohistochemistry (Paraffin), Western Blot to show that tau can directly interact with nucleoporins of the nuclear pore complex (NPC) and affect their structural and functional integrity.
Wed Sep 05 00:00:00 EDT 2018
Tau protein liquid-liquid phase separation can initiate tau aggregation.
The EMBO journal
Wegmann S,Eftekharzadeh B,Tepper K,Zoltowska KM,Bennett RE,Dujardin S,Laskowski PR,MacKenzie D,Kamath T,Commins C,Vanderburg C,Roe AD,Fan Z,Molliex AM,Hernandez-Vega A,Muller D,Hyman AA,Mandelkow E,Taylor JP,Hyman BT
MN1000 was used in Western Blotting to propose that soluble tau species can undergo liquid-liquid phase separation under cellular conditions and that phase-separated tau droplets can serve as an intermediate toward tau aggregate formation.
Tue Apr 03 00:00:00 EDT 2018
NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency.
Proceedings of the National Academy of Sciences of the United States of America
Hou Y,Lautrup S,Cordonnier S,Wang Y,Croteau DL,Zavala E,Zhang Y,Moritoh K,O'Connell JF,Baptiste BA,Stevnsner TV,Mattson MP,Bohr VA
MN1000 was used in Western Blotting to examine the role of compromised cellular bioenergetics and DNA repair in the pathogenesis of Alzheimer's disease.
Tue Feb 20 00:00:00 EST 2018
Tau protein aggregation is associated with cellular senescence in the brain.
Aging cell
Musi N,Valentine JM,Sickora KR,Baeuerle E,Thompson CS,Shen Q,Orr ME
MN1000 was used in Western Blot to indicate a strong association between the presence of NFTs and cellular senescence in the brain, which contributes to neurodegeneration.
Sat Dec 01 00:00:00 EST 2018
Differences in Gene Expression Profiles and Phenotypes of Differentiated SH-SY5Y Neurons Stably Overexpressing Mitochondrial Ferritin.
Frontiers in molecular neuroscience
Mendsaikhan A,Takeuchi S,Walker DG,Tooyama I
MN1000 was used in Western Blotting to determine whether mitochondrial ferritin has potential as a therapeutic approach for certain neurodegenerative and neurological diseases.
Wed Sep 30 00:00:00 EDT 2020
Brain regional synchronous activity predicts tauopathy in 3×TgAD mice.
Neurobiology of aging
Liu D,Lu H,Stein E,Zhou Z,Yang Y,Mattson MP
MN1000 was used in Immunohistochemistry-immunofluorescence to demonstrate that age-related brain regional hypersynchronous activity is associated with early tau pathology in a mouse model.
Mon Oct 01 00:00:00 EDT 2018
Effective Theranostic Cyanine for Imaging of Amyloid Species in Vivo and Cognitive Improvements in Mouse Model.
ACS omega
Li Y,Chen C,Xu D,Poon CY,Ho SL,Zheng R,Liu Q,Song G,Li HW,Wong MS
MN1000 was used in Immunohistochemistry to investigate the use of carbazole-based cyanine, (E)-4-(2-(9-(2-(2-methoxyethoxy)ethyl)-9H-carbazol-3-yl)-vinyl)-1-methyl-quinolin-1-iumiodide, as an effective theranostic agent for Alzheimer's disease.
Sat Jun 30 00:00:00 EDT 2018
Effective Theranostic Cyanine for Imaging of Amyloid Species in Vivo and Cognitive Improvements in Mouse Model.
ACS omega
Li Y,Chen C,Xu D,Poon CY,Ho SL,Zheng R,Liu Q,Song G,Li HW,Wong MS
MN1000 was used in Immunohistochemistry to investigate the use of carbazole-based cyanine, (E)-4-(2-(9-(2-(2-methoxyethoxy)ethyl)-9H-carbazol-3-yl)-vinyl)-1-methyl-quinolin-1-iumiodide, as an effective theranostic agent for Alzheimer's disease.
Sat Jun 30 00:00:00 EDT 2018
Probing Conformational Dynamics of Tau Protein by Hydrogen/Deuterium Exchange Mass Spectrometry.
Journal of the American Society for Mass Spectrometry
Huang RY,Iacob RE,Sankaranarayanan S,Yang L,Ahlijanian M,Tao L,Tymiak AA,Chen G
MN1000 was used in an ELISA assay to illustrate the practical utility of orthogonal analytical methodologies for the characterization of protein higher order structure.
Mon Jan 01 00:00:00 EST 2018
Dihydrolipoamide dehydrogenase suppression induces human tau phosphorylation by increasing whole body glucose levels in a C. elegans model of Alzheimer's Disease.
Experimental brain research
Ahmad W
MN1000 was used in Western Blot to conclude that any abnormalities in energy metabolism were found to significantly affect the AD disease pathology.
Thu Nov 01 00:00:00 EDT 2018
Effects of Resveratrol and Morin on Insoluble Tau in Tau Transgenic Mice.
Translational neuroscience
Yu KC,Kwan P,Cheung SKK,Ho A,Baum L
MN1000 was used in Western Blotting to evaluate morin and resveratrol for the treatment of tauopathy in JNPL3 P301L mutant human tau overexpressing mice.
Wed Sep 30 00:00:00 EDT 2020
Early intervention of tau pathology prevents behavioral changes in the rTg4510 mouse model of tauopathy.
PloS one
Wang X,Smith K,Pearson M,Hughes A,Cosden ML,Marcus J,Hess JF,Savage MJ,Rosahl T,Smith SM,Schachter JB,Uslaner JM
MN1000 was used in Western Blotting to investigate the response to early intervention in Tau pathology, using doxycycline and Thiamet G in the rTg4510 mouse model of tauopathy.
Wed Jul 25 00:00:00 EDT 2018
Calpain-mediated tau fragmentation is altered in Alzheimer's disease progression.
Scientific reports
Chen HH,Liu P,Auger P,Lee SH,Adolfsson O,Rey-Bellet L,Lafrance-Vanasse J,Friedman BA,Pihlgren M,Muhs A,Pfeifer A,Ernst J,Ayalon G,Wildsmith KR,Beach TG,van der Brug MP
MN1000 was used in Western Blotting to analyse endogenous tau fragmentation in Alzheimer's disease.
Tue Nov 13 00:00:00 EST 2018
The physiological phosphorylation of tau is critically changed in fetal brains of individuals with Down syndrome.
Neuropathology and applied neurobiology
Milenkovic I,Jarc J,Dassler E,Aronica E,Iyer A,Adle-Biassette H,Scharrer A,Reischer T,Hainfellner JA,Kovacs GG
MN1000 was used in ELISA, Immunohistochemistry- Free Floating, Immunohistochemistry (Paraffin), Western Blot to suggest functional tau disturbance in DS brains during development, rather than axonal loss.
Sun Apr 01 00:00:00 EDT 2018
Mutations in THAP1/DYT6 reveal that diverse dystonia genes disrupt similar neuronal pathways and functions.
PLoS genetics
Zakirova Z,Fanutza T,Bonet J,Readhead B,Zhang W,Yi Z,Beauvais G,Zwaka TP,Ozelius LJ,Blitzer RD,Gonzalez-Alegre P,Ehrlich ME
MN1000 was used in Immunocytochemistry-immunoflourescence to examine the neuronal pathways disrupted by the different disease-causing dystonia genes.
Mon Jan 01 00:00:00 EST 2018
Stabilizing the Retromer Complex in a Human Stem Cell Model of Alzheimer's Disease Reduces TAU Phosphorylation Independently of Amyloid Precursor Protein.
Stem cell reports
Young JE,Fong LK,Frankowski H,Petsko GA,Small SA,Goldstein LSB
MN1000 was used in Western Blotting to study the effects of stabilising the Retromer complex in a human stem cell model of Alzheimer's disease.
Tue Mar 13 00:00:00 EDT 2018
Isoform-independent and -dependent phosphorylation of microtubule-associated protein tau in mouse brain during postnatal development.
The Journal of biological chemistry
Tuerde D,Kimura T,Miyasaka T,Furusawa K,Shimozawa A,Hasegawa M,Ando K,Hisanaga SI
MN1000 was used in Western Blotting to study how the transition of the microtubule-associated protein tau isoforms and phosphorylation are regulated.
Fri Feb 02 00:00:00 EST 2018
Modifying Rap1-signalling by targeting Pde6δ is neuroprotective in models of Alzheimer's disease.
Molecular neurodegeneration
Dumbacher M,Van Dooren T,Princen K,De Witte K,Farinelli M,Lievens S,Tavernier J,Dehaen W,Wera S,Winderickx J,Allasia S,Kilonda A,Spieser S,Marchand A,Chaltin P,Hoogenraad CC,Griffioen G
MN1000 was used in Western Blotting to study the effects of pharmacological modulation of Rap1 signalling on Alzheimer's disease associated Ca2+ aberrations and neuronal activity.
Wed Sep 26 00:00:00 EDT 2018
Phosphorylation of different tau sites during progression of Alzheimer's disease.
Acta neuropathologica communications
Neddens J,Temmel M,Flunkert S,Kerschbaumer B,Hoeller C,Loeffler T,Niederkofler V,Daum G,Attems J,Hutter-Paier B
MN1000 was used in Immunohistochemistry to investigate total tau and phosphorylated tau as well as amyloid-Β plaques in human brain tissue of Alzheimer's disease patients and controls.
Fri Jun 29 00:00:00 EDT 2018
Tau deletion promotes brain insulin resistance.
The Journal of experimental medicine
Marciniak E,Leboucher A,Caron E,Ahmed T,Tailleux A,Dumont J,Issad T,Gerhardt E,Pagesy P,Vileno M,Bournonville C,Hamdane M,Bantubungi K,Lancel S,Demeyer D,Eddarkaoui S,Vallez E,Vieau D,Humez S,Faivre E,Grenier-Boley B,Outeiro TF,Staels B,Amouyel P,Balschun D,Buee L,Blum D
MN1000 was used in Immunocytochemistry-immunoflourescence to find that tau deletion leads to an impaired hippocampal response to insulin, caused by altered IRS-1 and PTEN activity.
Mon Aug 07 00:00:00 EDT 2017
Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network.
Acta neuropathologica
Takahashi H,Klein ZA,Bhagat SM,Kaufman AC,Kostylev MA,Ikezu T,Strittmatter SM
MN1000 was used in Immunohistochemistry to suggest that global PGRN reduction induces microglial TNG expression and increases AD risk by exacerbating neuronal injury and tau pathology.
Mon May 01 00:00:00 EDT 2017
Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy.
Brain : a journal of neurology
Laurent C,Dorothée G,Hunot S,Martin E,Monnet Y,Duchamp M,Dong Y,Légeron FP,Leboucher A,Burnouf S,Faivre E,Carvalho K,Caillierez R,Zommer N,Demeyer D,Jouy N,Sazdovitch V,Schraen-Maschke S,Delarasse C,Buée L,Blum D
MN1000 was used in western blot to explore the role of hippocampal T cell infiltration in tau-driven pathophysiology and cognitive impairments
Sun Jan 01 00:00:00 EST 2017
REST suppression mediates neural conversion of adult human fibroblasts via microRNA-dependent and -independent pathways.
EMBO molecular medicine
Drouin-Ouellet J,Lau S,Brattås PL,Rylander Ottosson D,Pircs K,Grassi DA,Collins LM,Vuono R,Andersson Sjöland A,Westergren-Thorsson G,Graff C,Minthon L,Toresson H,Barker RA,Jakobsson J,Parmar M
MN1000 was used in Immunocytochemistry to identify and overcome fibroblast reprogramming barrier to demonstrate induced neurons from elderly donors.
Tue Aug 01 00:00:00 EDT 2017
12/15-Lipoxygenase Inhibition Reverses Cognitive Impairment, Brain Amyloidosis, and Tau Pathology by Stimulating Autophagy in Aged Triple Transgenic Mice.
Biological psychiatry
Di Meco A,Li JG,Blass BE,Abou-Gharbia M,Lauretti E,Praticò D
MN1000 was used in immunohistochemistry and western blot to discuss the contribution of 12/15-lipoxygenase to Alzheimer's disease
Sun Jan 15 00:00:00 EST 2017
MAP2 Splicing is Altered in Huntington's Disease.
Brain pathology (Zurich, Switzerland)
Cabrera JR,Lucas JJ
MN1000 was used in immunohistochemistry - paraffin section to study alteration of MAP2 splicing in Huntington's disease
Wed Mar 01 00:00:00 EST 2017
Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro.
The American journal of pathology
Nobuhara CK,DeVos SL,Commins C,Wegmann S,Moore BD,Roe AD,Costantino I,Frosch MP,Pitstick R,Carlson GA,Hock C,Nitsch RM,Montrasio F,Grimm J,Cheung AE,Dunah AW,Wittmann M,Bussiere T,Weinreb PH,Hyman BT,Takeda S
MN1000 was used in an ELISA assay to discover that not all antibodies/epitopes are equally robust in terms of blocking tau uptake of human AD-derived tau species.
Thu Jun 01 00:00:00 EDT 2017
HNK-1 Carrier Glycoproteins Are Decreased in the Alzheimer's Disease Brain.
Molecular neurobiology
García-Ayllón MS,Botella-López A,Cuchillo-Ibañez I,Rábano A,Andreasen N,Blennow K,Ávila J,Sáez-Valero J
MN1000 was used in western blot to study the Alzheimer's disease brain for a decrease in HNK-1 carrier glycoproteins
Sun Jan 01 00:00:00 EST 2017
Pimozide reduces toxic forms of tau in TauC3 mice via 5' adenosine monophosphate-activated protein kinase-mediated autophagy.
Journal of neurochemistry
Kim YD,Jeong EI,Nah J,Yoo SM,Lee WJ,Kim Y,Moon S,Hong SH,Jung YK
MN1000 was used in Western Blotting to study the mechanism by which pimozide can rescue tau pathology in an Alzheimer's disease model.
Fri Sep 01 00:00:00 EDT 2017
Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects.
Scientific reports
Lathuilière A,Valdés P,Papin S,Cacquevel M,Maclachlan C,Knott GW,Muhs A,Paganetti P,Schneider BL
MN1000 was used in Immunohistochemistry to demonstrate that motifs that are critical for tau conformation determine interaction with microtubules and subsequent pathological modifications.
Thu Oct 19 00:00:00 EDT 2017
Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects.
Scientific reports
Lathuilière A,Valdés P,Papin S,Cacquevel M,Maclachlan C,Knott GW,Muhs A,Paganetti P,Schneider BL
MN1000 was used in Immunohistochemistry to demonstrate that motifs that are critical for tau conformation determine interaction with microtubules and subsequent pathological modifications.
Thu Oct 19 00:00:00 EDT 2017
Characterization of TauC3 antibody and demonstration of its potential to block tau propagation.
PloS one
Nicholls SB,DeVos SL,Commins C,Nobuhara C,Bennett RE,Corjuc DL,Maury E,Eftekharzadeh B,Akingbade O,Fan Z,Roe AD,Takeda S,Wegmann S,Hyman BT
MN1000 was used in Immunoprecipitation to propose that TauC3 could contribute to the templated tau misfolding that leads to neurofibrillary tangle spread in Alzheimer's disease.
Fri Sep 08 00:00:00 EDT 2017
Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.
Nature communications
Zhang Z,Obianyo O,Dall E,Du Y,Fu H,Liu X,Kang SS,Song M,Yu SP,Cabrele C,Schubert M,Li X,Wang JZ,Brandstetter H,Ye K
MN1000 was used in western blot to evaluate the efficacy of an orally bioactive and brain permeable gamma-secretase inhibitor in a mouse model of Alzheimer's disease
Mon Mar 27 00:00:00 EDT 2017
Amyloid-β dimers in the absence of plaque pathology impair learning and synaptic plasticity.
Brain : a journal of neurology
Müller-Schiffmann A,Herring A,Abdel-Hafiz L,Chepkova AN,Schäble S,Wedel D,Horn AH,Sticht H,de Souza Silva MA,Gottmann K,Sergeeva OA,Huston JP,Keyvani K,Korth C
MN1000 was used in western blot to assess the impairment in synaptic plasticity and learning due to amyloid-beta dimers in the absence of plaque pathology
Mon Feb 01 00:00:00 EST 2016
Maternal dexamethasone exposure ameliorates cognition and tau pathology in the offspring of triple transgenic AD mice.
Molecular psychiatry
Di Meco A,Joshi YB,Lauretti E,Praticò D
MN1000 was used in western blot to study amelioration of tau pathology and cognition in the offspring of triple transgenic AD mice by maternal dexamethasone exposure
Tue Mar 01 00:00:00 EST 2016
Seed-competent high-molecular-weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients.
Annals of neurology
Takeda S,Commins C,DeVos SL,Nobuhara CK,Wegmann S,Roe AD,Costantino I,Fan Z,Nicholls SB,Sherman AE,Trisini Lipsanopoulos AT,Scherzer CR,Carlson GA,Pitstick R,Peskind ER,Raskind MA,Li G,Montine TJ,Frosch MP,Hyman BT
MN1000 was used in blocking or activating experiment to assess the accumulation in the cerebrospinal fluid of seed-competent HMW tau specis in an Alzheimer's disease mouse model and in human patients
Thu Sep 01 00:00:00 EDT 2016
α-Synuclein pre-formed fibrils impair tight junction protein expression without affecting cerebral endothelial cell function.
Experimental neurology
Kuan WL,Bennett N,He X,Skepper JN,Martynyuk N,Wijeyekoon R,Moghe PV,Williams-Gray CH,Barker RA
MN1000 was used in immunocytochemistry to test if alpha-synuclein preformed fibrils alter endothelial function
Tue Nov 01 00:00:00 EDT 2016
Obesity, diabetes, and leptin resistance promote tau pathology in a mouse model of disease.
Neuroscience
Platt TL,Beckett TL,Kohler K,Niedowicz DM,Murphy MP
MN1000 was used in western blot to characterize tau pathology mouse models via obesity, diabetes, and leptin resistance
Fri Feb 19 00:00:00 EST 2016
Impulsivity, decreased social exploration, and executive dysfunction in a mouse model of frontotemporal dementia.
Neurobiology of learning and memory
Van der Jeugd A,Vermaercke B,Halliday GM,Staufenbiel M,Götz J
MN1000 was used in immunohistochemistry - paraffin section to elucidate a mouse model of frontotemporal dementia by decreased social exploration, impulsivity, and executive dysfunction
Fri Apr 01 00:00:00 EDT 2016
Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun.
Developmental dynamics : an official publication of the American Association of Anatomists
Gurdziel K,Vogt KR,Walton KD,Schneider GK,Gumucio DL
MN1000 was used in western blot to study the inner circular smooth muscle of the developing mouse intestine transcriptome: evidence that the hedgehog target gene, cJun, regulates visceral smooth muscle genes
Sun May 01 00:00:00 EDT 2016
Increased tauopathy drives microglia-mediated clearance of beta-amyloid.
Acta neuropathologica communications
Chen W,Abud EA,Yeung ST,Lakatos A,Nassi T,Wang J,Blum D,Buée L,Poon WW,Blurton-Jones M
MN1000 was used in Immunohistochemistry to study the interplay between AΒ deposition, tau pathology and microgliosis in Alzheimer's disease.
Thu Jun 23 00:00:00 EDT 2016
Increased tauopathy drives microglia-mediated clearance of beta-amyloid.
Acta neuropathologica communications
Chen W,Abud EA,Yeung ST,Lakatos A,Nassi T,Wang J,Blum D,Buée L,Poon WW,Blurton-Jones M
MN1000 was used in Immunohistochemistry to study the interplay between AΒ deposition, tau pathology and microgliosis in Alzheimer's disease.
Thu Jun 23 00:00:00 EDT 2016
Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment.
Molecular neurodegeneration
Sohn PD,Tracy TE,Son HI,Zhou Y,Leite RE,Miller BL,Seeley WW,Grinberg LT,Gan L
MN1000 was used in western blot to investigate the axon initial segment in neurological disorders
Wed Jun 29 00:00:00 EDT 2016
Accumulation of human full-length tau induces degradation of nicotinic acetylcholine receptor α4 via activating calpain-2.
Scientific reports
Yin Y,Wang Y,Gao D,Ye J,Wang X,Fang L,Wu D,Pi G,Lu C,Zhou XW,Yang Y,Wang JZ
MN1000 was used in western blot to assess induction of degradation of nicotinic acetylcholine receptor alpha4 via activating calpain-2 due to accumulation of human full-length tau
Thu Jun 09 00:00:00 EDT 2016
Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo.
Scientific reports
Gorsky MK,Burnouf S,Dols J,Mandelkow E,Partridge L
MN1000 was used in western blot to elucidate the exacerbation of human Tau neurotoxicity in vivo by acetylation mimic of lysine 280
Fri Mar 04 00:00:00 EST 2016
Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement.
Cell reports
Lee SH,Le Pichon CE,Adolfsson O,Gafner V,Pihlgren M,Lin H,Solanoy H,Brendza R,Ngu H,Foreman O,Chan R,Ernst JA,DiCara D,Hotzel I,Srinivasan K,Hansen DV,Atwal J,Lu Y,Bumbaca D,Pfeifer A,Watts RJ,Muhs A,Scearce-Levie K,Ayalon G
MN1000 was used in immunocytochemistry, immunohistochemistry - paraffin section, and western blot to test if antibody effector function is required for limiting the spread of tau
Tue Aug 09 00:00:00 EDT 2016
Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits.
Nature medicine
Min SW,Chen X,Tracy TE,Li Y,Zhou Y,Wang C,Shirakawa K,Minami SS,Defensor E,Mok SA,Sohn PD,Schilling B,Cong X,Ellerby L,Gibson BW,Johnson J,Krogan N,Shamloo M,Gestwicki J,Masliah E,Verdin E,Gan L
MN1000 was used in immunohistochemistry - free floating to investigate the effects of tau acetylation at Lys174
Thu Oct 01 00:00:00 EDT 2015
Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies.
Acta neuropathologica
Wagner J,Krauss S,Shi S,Ryazanov S,Steffen J,Miklitz C,Leonov A,Kleinknecht A,Göricke B,Weishaupt JH,Weckbecker D,Reiner AM,Zinth W,Levin J,Ehninger D,Remy S,Kretzschmar HA,Griesinger C,Giese A,Fuhrmann M
MN1000 was used in western blot to report that the di-phenyl-pyrazole anle138b binds to and inhibits tau aggregation in vitro and in vivo
Sun Nov 01 00:00:00 EDT 2015
Internalized Tau Oligomers Cause Neurodegeneration by Inducing Accumulation of Pathogenic Tau in Human Neurons Derived from Induced Pluripotent Stem Cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Usenovic M,Niroomand S,Drolet RE,Yao L,Gaspar RC,Hatcher NG,Schachter J,Renger JJ,Parmentier-Batteur S
MN1000 was used in Immunocytochemistry to investigate the cellular and molecular mechanisms of tau pathology propagation.
Wed Oct 21 00:00:00 EDT 2015
Reducing Ribosomal Protein S6 Kinase 1 Expression Improves Spatial Memory and Synaptic Plasticity in a Mouse Model of Alzheimer's Disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Caccamo A,Branca C,Talboom JS,Shaw DM,Turner D,Ma L,Messina A,Huang Z,Wu J,Oddo S
MN1000 was used in western blot to investigate Alzheimer's Disease in a mouse model where ribosomal protein S6 kinase is decreased
Wed Oct 14 00:00:00 EDT 2015
Sustained high levels of neuroprotective, high molecular weight, phosphorylated tau in the longest-lived rodent.
Neurobiology of aging
Orr ME,Garbarino VR,Salinas A,Buffenstein R
MN1000 was used in Western Blot to propose that this 88 kDa tau protein may offer exceptional microtubule stability and neuroprotection against lifelong, elevated Aß.
Sun Mar 01 00:00:00 EST 2015
Modulation of AD neuropathology and memory impairments by the isoprostane F2α is mediated by the thromboxane receptor.
Neurobiology of aging
Lauretti E,Di Meco A,Chu J,Praticò D
MN1000 was used in immunohistochemistry - paraffin section and western blot to characterize the behavioral, biochemical, and neuropathologic effects of 8ISO in the triple transgenic mouse model of Alzheimer's disease
Sun Feb 01 00:00:00 EST 2015
Lack of exacerbation of neurodegeneration in a double transgenic mouse model of mutant LRRK2 and tau.
Human molecular genetics
Mikhail F,Calingasan N,Parolari L,Subramanian A,Yang L,Flint Beal M
MN1000 was used in Western Blotting to examine the relationship between leucine-rich repeat kinase 2 and tau.
Mon Jun 15 00:00:00 EDT 2015
Carboxy terminus heat shock protein 70 interacting protein reduces tau-associated degenerative changes.
Journal of Alzheimer's disease : JAD
Saidi LJ,Polydoro M,Kay KR,Sanchez L,Mandelkow EM,Hyman BT,Spires-Jones TL
MN1000 was used in immunocytochemistry and western blot to test if CHIP ameliorates the pathological changes associated with tau aggregation.
Mon Oct 26 00:00:00 EDT 2015
Carboxy terminus heat shock protein 70 interacting protein reduces tau-associated degenerative changes.
Journal of Alzheimer's disease : JAD
Saidi LJ,Polydoro M,Kay KR,Sanchez L,Mandelkow EM,Hyman BT,Spires-Jones TL
MN1000 was used in immunocytochemistry and western blot to test if CHIP ameliorates the pathological changes associated with tau aggregation.
Mon Oct 26 00:00:00 EDT 2015
Restoration of lipoxin A4 signaling reduces Alzheimer's disease-like pathology in the 3xTg-AD mouse model.
Journal of Alzheimer's disease : JAD
Dunn HC,Ager RR,Baglietto-Vargas D,Cheng D,Kitazawa M,Cribbs DH,Medeiros R
MN1000 was used in western blot to assess the effect of aging on brain lipoxin A4 levels using non-transgenic and 3xTg-AD mice.
Fri Aug 21 00:00:00 EDT 2015
Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology.
Molecular neurodegeneration
Song L,Lu SX,Ouyang X,Melchor J,Lee J,Terracina G,Wang X,Hyde L,Hess JF,Parker EM,Zhang L
MN1000 was used in western blot to use rTg4510 mice to elucidate pathogenesis of tau-induced disease.
Thu Mar 26 00:00:00 EDT 2015
Caspase-Cleaved Tau Co-Localizes with Early Tangle Markers in the Human Vascular Dementia Brain.
PloS one
Day RJ,Mason MJ,Thomas C,Poon WW,Rohn TT
MN1000 was used in Western Blotting to investigate a potential role for caspase-cleaved tau in vascular dementia.
Tue Apr 19 00:00:00 EDT 2016
Conformation determines the seeding potencies of native and recombinant Tau aggregates.
The Journal of biological chemistry
Falcon B,Cavallini A,Angers R,Glover S,Murray TK,Barnham L,Jackson S,O'Neill MJ,Isaacs AM,Hutton ML,Szekeres PG,Goedert M,Bose S
MN1000 was used in immunocytochemistry and western blot to determine seeding potencies of recombinant and native Tau aggregates due to conformation
Fri Jan 09 00:00:00 EST 2015
Huntington's disease is a four-repeat tauopathy with tau nuclear rods.
Nature medicine
Fernández-Nogales M,Cabrera JR,Santos-Galindo M,Hoozemans JJ,Ferrer I,Rozemuller AJ,Hernández F,Avila J,Lucas JJ
MN1000 was used in immunohistochemistry to investigate the role of tau missplicing in the pathogenesis of Huntington disease
Fri Aug 01 00:00:00 EDT 2014
Increased expression of the receptor for advanced glycation end products in neurons and astrocytes in a triple transgenic mouse model of Alzheimer's disease.
Experimental & molecular medicine
Choi BR,Cho WH,Kim J,Lee HJ,Chung C,Jeon WK,Han JS
MN1000 was used in immunohistochemistry to study the elevated neuronal and astrocyte expression of RAGE in a murine transgenic model of Alzheimer's disease
Fri Feb 07 00:00:00 EST 2014
Synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of Alzheimer's disease.
Neurobiology of disease
Chabrier MA,Cheng D,Castello NA,Green KN,LaFerla FM
MN1000 was used in immunohistochemistry and western blot to study dendritic spine loss in a transgenic murine model of Alzheimer's disease and the synergistic effects of Abeta and tau
Tue Apr 01 00:00:00 EDT 2014
Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition.
Neurobiology of disease
Baglietto-Vargas D,Kitazawa M,Le EJ,Estrada-Hernandez T,Rodriguez-Ortiz CJ,Medeiros R,Green KN,LaFerla FM
MN1000 was used in western blot to study the effect of endogenous murine tau on cognition and neurofibrillary tangles in a murine Alzheimer's disease model transgenically expressing human tau
Sat Feb 01 00:00:00 EST 2014
Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Castillo-Carranza DL,Sengupta U,Guerrero-Muñoz MJ,Lasagna-Reeves CA,Gerson JE,Singh G,Estes DM,Barrett AD,Dineley KT,Jackson GR,Kayed R
MN1000 was used in ELISA and immunohistochemistry to study the ability of an anti-oligomeric tau monoclonal antibody to specifically reduce oligomeric tau and improve memory and locomotion in a murine Alzheimer's disease model
Wed Mar 19 00:00:00 EDT 2014
Suppression of InsP3 receptor-mediated Ca2+ signaling alleviates mutant presenilin-linked familial Alzheimer's disease pathogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Shilling D,Müller M,Takano H,Mak DO,Abel T,Coulter DA,Foskett JK
MN1000 was used in western blot to study the role of exagerated Ca(2+) signaling mediated by InsP3 receptor1 in the pathogenesis of mutant presenilin-linked Alzheimer's disease
Wed May 14 00:00:00 EDT 2014
Premature lethality, hyperactivity, and aberrant phosphorylation in transgenic mice expressing a constitutively active form of Fyn.
Frontiers in molecular neuroscience
Xia D,Götz J
MN1000 was used in western blot to study the effects of transgenically expressing a constitutively active Y531F Fyn mutant on murine life-span, activity and protein phosphorylation
Mon May 26 00:00:00 EDT 2014
α7 Nicotinic receptor agonist enhances cognition in aged 3xTg-AD mice with robust plaques and tangles.
The American journal of pathology
Medeiros R,Castello NA,Cheng D,Kitazawa M,Baglietto-Vargas D,Green KN,Esbenshade TA,Bitner RS,Decker MW,LaFerla FM
MN1000 was used in Western Blotting to determine the effect of long-term treatment with the selective α7 nAChR agonist A-582941 in aged 3xTg-AD mice with robust Alzheimer's disease-like pathology.
Sat Feb 01 00:00:00 EST 2014
Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice.
Experimental neurology
Yamada ES,Respondek G,Müssner S,de Andrade A,Höllerhage M,Depienne C,Rastetter A,Tarze A,Friguet B,Salama M,Champy P,Oertel WH,Höglinger GU
MN1000 was used in western blot to study the increased tau phosphorylation following treatment with a mitochondrial complex I inhibitor in a tau transgenic mouse model
Sat Mar 01 00:00:00 EST 2014
Increased O-GlcNAcylation reduces pathological tau without affecting its normal phosphorylation in a mouse model of tauopathy.
Neuropharmacology
Graham DL,Gray AJ,Joyce JA,Yu D,O'Moore J,Carlson GA,Shearman MS,Dellovade TL,Hering H
MN1000 was used in immunoprecipitation to study the mechanism by which O-GlcNAcylation prevents pathological agregation of tau in a murine tauopathy model
Tue Apr 01 00:00:00 EDT 2014
Sleep deprivation impairs memory, tau metabolism, and synaptic integrity of a mouse model of Alzheimer's disease with plaques and tangles.
Neurobiology of aging
Di Meco A,Joshi YB,Praticò D
MN1000 was used in western blot to study the deleterious effects of sleep deprivation on memory and Tau pathology in a murine Alzheimer's disease model
Fri Aug 01 00:00:00 EDT 2014
Age-related downregulation of the CaV3.1 T-type calcium channel as a mediator of amyloid beta production.
Neurobiology of aging
Rice RA,Berchtold NC,Cotman CW,Green KN
MN1000 was used in immunohistochemistry and western blot to study the potential mechanism by which the age-related decline in CaV3.1 T-type calcium channel expression leads to increased production of beta-amyloid
Thu May 01 00:00:00 EDT 2014
Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology.
Neurobiology of aging
Orr ME,Salinas A,Buffenstein R,Oddo S
MN1000 was used in western blot to study the role of mTOR hyperactivation in the mechanism by which a high-sucrose diet promotes beta-amyloid pathology in Alzheimer's disease
Sun Jun 01 00:00:00 EDT 2014
Tau silencing by siRNA in the P301S mouse model of tauopathy.
Current gene therapy
Xu H,Rösler TW,Carlsson T,de Andrade A,Fiala O,Hollerhage M,Oertel WH,Goedert M,Aigner A,Höglinger GU
MN1000 was used in western blot to investigate the cerebral delivery of small interfering RNAs targeting human tau
Tue Oct 13 00:00:00 EDT 2015
Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology.
Biological psychiatry
Baglietto-Vargas D,Medeiros R,Martinez-Coria H,LaFerla FM,Green KN
MN1000 was used in western blot to study the reduced alpha- and beta-cleavage of APP and reduced phosporylated tau accumulation in transgenic mice treated with mifepristone
Sun Sep 01 00:00:00 EDT 2013
Tau-tubulin kinase 1 expression, phosphorylation and co-localization with phospho-Ser422 tau in the Alzheimer's disease brain.
Brain pathology (Zurich, Switzerland)
Lund H,Cowburn RF,Gustafsson E,Strömberg K,Svensson A,Dahllund L,Malinowsky D,Sunnemark D
MN1000 was used in ELISA to investigate the characteristics of TTBK1 in the brain of AD patients
Mon Jul 01 00:00:00 EDT 2013
Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy.
Neurobiology of aging
Nash KR,Lee DC,Hunt JB,Morganti JM,Selenica ML,Moran P,Reid P,Brownlow M,Guang-Yu Yang C,Savalia M,Gemma C,Bickford PC,Gordon MN,Morgan D
MN1000 was used in western blot to study the beneficial effects on tau pathology in a murine transgenic tauopathy model of the virally-mediated overexpression of soluble fractalkine
Sat Jun 01 00:00:00 EDT 2013
Impact of N-tau on adult hippocampal neurogenesis, anxiety, and memory.
Neurobiology of aging
Pristerà A,Saraulli D,Farioli-Vecchioli S,Strimpakos G,Costanzi M,di Certo MG,Cannas S,Ciotti MT,Tirone F,Mattei E,Cestari V,Canu N
MN1000 was used in immunocytochemistry and immunohistochemistry to study the effects of a pathogenic tau fragment on hippocampal neurogenesis, behaviour and learning
Fri Nov 01 00:00:00 EDT 2013
Active glycogen synthase kinase-3 and tau pathology-related tyrosine phosphorylation in pR5 human tau transgenic mice.
Neurobiology of aging
Köhler C,Dinekov M,Götz J
MN1000 was used in western blot to study the association of GSK3 activity with tau phosphorylation and neuronal tyrosine phosphorylation in a murine model expressing human P301L tau
Wed May 01 00:00:00 EDT 2013
Pattern of tau hyperphosphorylation and neurotransmitter markers in the brainstem of senescent tau filament forming transgenic mice.
Brain research
Morcinek K,Köhler C,Götz J,Schröder H
MN1000 was used in immunohistochemistry to study whether the expression of mutant human tau in tau filament-forming mice recapitulates the pathological chages observed in Alzheimer's disease brainstem
Mon Feb 25 00:00:00 EST 2013
Synaptic alterations in the rTg4510 mouse model of tauopathy.
The Journal of comparative neurology
Kopeikina KJ,Polydoro M,Tai HC,Yaeger E,Carlson GA,Pitstick R,Hyman BT,Spires-Jones TL
MN1000 was used in western blot to study the tau-induced loss of synapses in a murine model overexpressing the P301L mutant tau
Mon Apr 15 00:00:00 EDT 2013
Increasing brain protein O-GlcNAc-ylation mitigates breathing defects and mortality of Tau.P301L mice.
PloS one
Borghgraef P,Menuet C,Theunis C,Louis JV,Devijver H,Maurin H,Smet-Nocca C,Lippens G,Hilaire G,Gijsen H,Moechars D,Van Leuven F
MN1000 was used in immunohistochemistry, immunoprecipitation, and western blot to study the beneficial effects of increasing the O-GlucNAcylation of brain proteins on the survival and breathing of aged tau P301L transgenic mice
Mon Oct 13 00:00:00 EDT 2014
Subjects harboring presenilin familial Alzheimer's disease mutations exhibit diverse white matter biochemistry alterations.
American journal of neurodegenerative disease
Roher AE,Maarouf CL,Malek-Ahmadi M,Wilson J,Kokjohn TA,Daugs ID,Whiteside CM,Kalback WM,Macias MP,Jacobson SA,Sabbagh MN,Ghetti B,Beach TG
MN1000 was used in Western Blotting to study PSEN mutations by quantifying the white matter (WM) levels of Aβ peptides, as well as 21 other WM proteins and 2 grey matter synaptic molecules.
Fri Oct 04 00:00:00 EDT 2013
Efficacy and safety of a liposome-based vaccine against protein Tau, assessed in tau.P301L mice that model tauopathy.
PloS one
Theunis C,Crespo-Biel N,Gafner V,Pihlgren M,López-Deber MP,Reis P,Hickman DT,Adolfsson O,Chuard N,Ndao DM,Borghgraef P,Devijver H,Van Leuven F,Pfeifer A,Muhs A
MN1000 was used in Western Blotting to demonstrate that a liposome-based vaccine elicited, rapidly and robustly, specific antisera in wild-type mice and in Tau.P301L mice.
Thu Jan 22 00:00:00 EST 2015
PINCH in the cellular stress response to tau-hyperphosphorylation.
PloS one
Ozdemir AY,Rom I,Kovalevich J,Yen W,Adiga R,Dave RS,Langford D
MN1000 was used in western blot to study the ability of PINCH in bind and stabilize hyperphoshorylated tau
Mon Sep 30 00:00:00 EDT 2013
Propagation of tau pathology in a model of early Alzheimer's disease.
Neuron
de Calignon A,Polydoro M,Suárez-Calvet M,William C,Adamowicz DH,Kopeikina KJ,Pitstick R,Sahara N,Ashe KH,Carlson GA,Spires-Jones TL,Hyman BT
MN1000 was used in immunohistochemistry and western blot to study the propagation of tau pathology in a model of early Alzheimer's disease
Thu Feb 23 00:00:00 EST 2012
Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers.
Brain : a journal of neurology
Attar A,Ripoli C,Riccardi E,Maiti P,Li Puma DD,Liu T,Hayes J,Jones MR,Lichti-Kaiser K,Yang F,Gale GD,Tseng CH,Tan M,Xie CW,Straudinger JL,Klärner FG,Schrader T,Frautschy SA,Grassi C,Bitan G
MN1000 was used in immunohistochemistry to study the ability of lysine-specific molecular tweezers to protect against Alzheimer's disease pathology
Sat Dec 01 00:00:00 EST 2012
The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Zhang B,Carroll J,Trojanowski JQ,Yao Y,Iba M,Potuzak JS,Hogan AM,Xie SX,Ballatore C,Smith AB,Lee VM,Brunden KR
MN1000 was used in ELISA to study mechaisms underlying the therapeutic effects of epothilone D in a murine transgenic tau model and the significance for Alzheimer's disease
Wed Mar 14 00:00:00 EDT 2012
Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice.
The American journal of pathology
Medeiros R,Kitazawa M,Chabrier MA,Cheng D,Baglietto-Vargas D,Kling A,Moeller A,Green KN,LaFerla FM
MN1000 was used in western blot to study the beneficial effects of a novel calpain inhibitor on Alzheimers's disease pathology and cognitive decline in transgenic mouse model
Wed Aug 01 00:00:00 EDT 2012
Altered expression of brain acetylcholinesterase in FTDP-17 human tau transgenic mice.
Neurobiology of aging
Silveyra MX,García-Ayllón MS,de Barreda EG,Small DH,Martínez S,Avila J,Sáez-Valero J
MN1000 was used in western blot to identify the relationship between acetylcholinesterase and P-tau expression in neurodegeneration
Thu Mar 01 00:00:00 EST 2012
Frontal cortex neuropathology in dementia pugilistica.
Journal of neurotrauma
Saing T,Dick M,Nelson PT,Kim RC,Cribbs DH,Head E
MN1000 was used in immunohistochemistry to investigate the neuropathological changes in dementia pugilistica patients
Tue Apr 10 00:00:00 EDT 2012
Effects of the superoxide dismutase/catalase mimetic EUK-207 in a mouse model of Alzheimer's disease: protection against and interruption of progression of amyloid and tau pathology and cognitive decline.
Journal of Alzheimer's disease : JAD
Clausen A,Xu X,Bi X,Baudry M
MN1000 was used in immunohistochemistry to study the role of oxidative stress in Alzheimer's disease pathogenesis and progression
Mon Sep 10 00:00:00 EDT 2012
Clinical, neuropathological, and biochemical characterization of the novel tau mutation P332S.
Journal of Alzheimer's disease : JAD
Deramecourt V,Lebert F,Maurage CA,Fernandez-Gomez FJ,Dujardin S,Colin M,Sergeant N,Buée-Scherrer V,Clot F,Ber IL,Brice A,Pasquier F,Buée L
MN1000 was used in western blot to study the clinical and molecular characteristics of a novel P332S tau mutation
Mon Jul 08 00:00:00 EDT 2013
Prolonged nitric oxide treatment induces tau aggregation in SH-SY5Y cells.
Neuroscience letters
Takahashi M,Chin Y,Nonaka T,Hasegawa M,Watanabe N,Arai T
MN1000 was used in western blot to investigate the effect of prolonged NO treatment on the aggregation of tau in SH-SY5Y cells
Tue Feb 21 00:00:00 EST 2012
Hippocampal BDNF expression in a tau transgenic mouse model.
Current Alzheimer research
Burnouf S,Belarbi K,Troquier L,Derisbourg M,Demeyer D,Leboucher A,Laurent C,Hamdane M,Buee L,Blum D
MN1000 was used in western blot to study whether tau pathology is associated with BDNF downregulation in a transgenic mouse model
Tue May 01 00:00:00 EDT 2012
Intranasal deferoxamine improves performance in radial arm water maze, stabilizes HIF-1α, and phosphorylates GSK3β in P301L tau transgenic mice.
Experimental brain research
Fine JM,Baillargeon AM,Renner DB,Hoerster NS,Tokarev J,Colton S,Pelleg A,Andrews A,Sparley KA,Krogh KM,Frey WH,Hanson LR
MN1000 was used in western blot to study the molecular and behavioural effects of deferoxamine in tau transgenic mice
Fri Jun 01 00:00:00 EDT 2012
LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth.
PloS one
Kawakami F,Yabata T,Ohta E,Maekawa T,Shimada N,Suzuki M,Maruyama H,Ichikawa T,Obata F
MN1000 was used in western blot to investigate the important roles of LRRK2 in phosphorylation-mediated dissociation of tau from microtubules
Mon Jun 11 00:00:00 EDT 2012
Membrane-microdomain localization of amyloid β-precursor protein (APP) C-terminal fragments is regulated by phosphorylation of the cytoplasmic Thr668 residue.
The Journal of biological chemistry
Matsushima T,Saito Y,Elliott JI,Iijima-Ando K,Nishimura M,Kimura N,Hata S,Yamamoto T,Nakaya T,Suzuki T
MN1000 was used in western blot to study the role of phosphorylation in the membrane-microdomain localization of amyloid ?-precursor protein C-terminal fragments
Fri Jun 01 00:00:00 EDT 2012
Human P301L-mutant tau expression in mouse entorhinal-hippocampal network causes tau aggregation and presynaptic pathology but no cognitive deficits.
PloS one
Harris JA,Koyama A,Maeda S,Ho K,Devidze N,Dubal DB,Yu GQ,Masliah E,Mucke L
MN1000 was used in immunohistochemistry to study whether tau pathology caused by overexpression of mutant P301L tau in the murine entorhinal-hippocampal network leads to cognitive defects
Thu Feb 28 00:00:00 EST 2013
A peculiar constellation of tau pathology defines a subset of dementia in the elderly.
Acta neuropathologica
Kovacs GG,Molnár K,László L,Ströbel T,Botond G,Hönigschnabl S,Reiner-Concin A,Palkovits M,Fischer P,Budka H
MN1000 was used in immunohistochemistry to investigate the changes of tau pattern in some older patients with dementia
Mon Aug 01 00:00:00 EDT 2011
Morin attenuates tau hyperphosphorylation by inhibiting GSK3β.
Neurobiology of disease
Gong EJ,Park HR,Kim ME,Piao S,Lee E,Jo DG,Chung HY,Ha NC,Mattson MP,Lee J
MN1000 was used in immunohistochemistry to study the ability of the GSKbeta inhibitor morin to reduce tau hyperphosphorylation
Tue Nov 01 00:00:00 EDT 2011
Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-β accumulation and independently accelerates the development of tau abnormalities.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Tran HT,LaFerla FM,Holtzman DM,Brody DL
MN1000 was used in immunohistochemistry to investigate the effect of traumatic brain injury on the development of Alzheimer disease pathology
Wed Jun 29 00:00:00 EDT 2011
Loss of muscarinic M1 receptor exacerbates Alzheimer's disease-like pathology and cognitive decline.
The American journal of pathology
Medeiros R,Kitazawa M,Caccamo A,Baglietto-Vargas D,Estrada-Hernandez T,Cribbs DH,Fisher A,LaFerla FM
MN1000 was used in western blot to study the deleterious effects of muscarinic M1 receptor knockout on Alzheimer's disease pathology and cognitive decline in a transgenic mouse model
Mon Aug 01 00:00:00 EDT 2011
Decrease in brain soluble amyloid precursor protein β (sAPPβ) in Alzheimer's disease cortex.
Journal of neuroscience research
Wu G,Sankaranarayanan S,Hsieh SH,Simon AJ,Savage MJ
MN1000 was used in ELISA to study the sAPPb decrease in Alzheimer disease cortex
Wed Jun 01 00:00:00 EDT 2011
Tau transgenic mice as models for cerebrospinal fluid tau biomarkers.
Journal of Alzheimer's disease : JAD
Barten DM,Cadelina GW,Hoque N,DeCarr LB,Guss VL,Yang L,Sankaranarayanan S,Wes PD,Flynn ME,Meredith JE,Ahlijanian MK,Albright CF
MN1000 was used in immunohistochemistry to detect Tau protein in cerebrospinal fluid
Fri Sep 30 00:00:00 EDT 2011
Hippocampal tauopathy in tau transgenic mice coincides with impaired hippocampus-dependent learning and memory, and attenuated late-phase long-term depression of synaptic transmission.
Neurobiology of learning and memory
Van der Jeugd A,Ahmed T,Burnouf S,Belarbi K,Hamdame M,Grosjean ME,Humez S,Balschun D,Blum D,Buée L,D'Hooge R
MN1000 was used in western blot to investigate the influence of hippocampal tauopathy in learning, memory and neural functions in transgenic mice
Tue Mar 01 00:00:00 EST 2011
6-amino-4-(pyrimidin-4-yl)pyridones: novel glycogen synthase kinase-3β inhibitors.
Bioorganic & medicinal chemistry letters
Coffman K,Brodney M,Cook J,Lanyon L,Pandit J,Sakya S,Schachter J,Tseng-Lovering E,Wessel M
MN1000 was used in immunoprecipitation to identify and characterize a novel class of GSK3 beta inhibitors
Tue Mar 01 00:00:00 EST 2011
Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice.
Molecular neurodegeneration
Lasagna-Reeves CA,Castillo-Carranza DL,Sengupta U,Clos AL,Jackson GR,Kayed R
MN1000 was used in immunohistochemistry to investigate the influence of tau oligomer on neuronal morphology and function in mice
Mon Jun 06 00:00:00 EDT 2011
Early oligodendrocyte/myelin pathology in Alzheimer's disease mice constitutes a novel therapeutic target.
The American journal of pathology
Desai MK,Mastrangelo MA,Ryan DA,Sudol KL,Narrow WC,Bowers WJ
MN1000 was used in immunohistochemistry to investigate the effect of Abeta(1-42) on the survival of mOP cells in Alzheimer disease mouse model
Wed Sep 01 00:00:00 EDT 2010
Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice.
The American journal of pathology
Martinez-Coria H,Green KN,Billings LM,Kitazawa M,Albrecht M,Rammes G,Parsons CG,Gupta S,Banerjee P,LaFerla FM
MN1000 was used in western blot to investigate the effect of memantine on Alzheimer disease treatment in mice
Mon Feb 01 00:00:00 EST 2010
GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease.
Journal of Alzheimer's disease : JAD
Li Y,Duffy KB,Ottinger MA,Ray B,Bailey JA,Holloway HW,Tweedie D,Perry T,Mattson MP,Kapogiannis D,Sambamurti K,Lahiri DK,Greig NH
MN1000 was used in western blot to investigate the effect of GLP-1 receptor stimulation on amyloid-beta peptide accumulation and cytotoxicity in Alzheimer disease model
Thu Jul 22 00:00:00 EDT 2010
Analysis of the cholinergic pathology in the P301L tau transgenic pR5 model of tauopathy.
Brain research
Köhler C,Bista P,Götz J,Schröder H
MN1000 was used in immunohistochemistry to analyze the cholinergic pathology in a tauopathy model
Fri Aug 06 00:00:00 EDT 2010
Gateway-compatible lentiviral transfer vectors for ubiquitin promoter driven expression of fluorescent fusion proteins.
Plasmid
Krupka N,Strappe P,Götz J,Ittner LM
MN1000 was used in western blot to evaluate the transfection vector for fluorescent fusion protei expression in 293T and SH-SY5Y cells
Sat May 01 00:00:00 EDT 2010
Spatially pathogenic forms of tau detected in Alzheimer's disease brain tissue by fluorescence lifetime-based Förster resonance energy transfer.
Journal of neuroscience methods
Larionov S,Wielgat P,Wang Y,Thal DR,Neumann H
MN1000 was used in immunohistochemistry to develop a FRET-based method to detect pathogenic forms of tau.
Thu Sep 30 00:00:00 EDT 2010
Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments.
The Journal of biological chemistry
Caccamo A,Majumder S,Richardson A,Strong R,Oddo S
MN1000 was used in Immunocytochemistry-immunoflourescence to elucidate the molecular mechanisms linking amyloid-beta to cognitive decline.
Fri Apr 23 00:00:00 EDT 2010
Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice.
PloS one
Bittner T,Fuhrmann M,Burgold S,Ochs SM,Hoffmann N,Mitteregger G,Kretzschmar H,LaFerla FM,Herms J
MN1000 was used in immunohistochemistry to investigate the dendritic spine loss during the progression of Alzheimer disease in a mouse model
Tue Nov 16 00:00:00 EST 2010
A cellular model to monitor proteasome dysfunction by alpha-synuclein.
Biochemistry
Nonaka T,Hasegawa M
MN1000 was used in western blot to study the effect of alpha-synuclein on proteasome function
Tue Aug 25 00:00:00 EDT 2009
ER stress is involved in Abeta-induced GSK-3beta activation and tau phosphorylation.
Journal of neuroscience research
Resende R,Ferreiro E,Pereira C,Oliveira CR
MN1000 was used in western blot to study the mechanism for the induction of tau phosphorylation by amyloid beta peptide
Tue Jul 01 00:00:00 EDT 2008
Biochemical characterization of Abeta and tau pathologies in mild cognitive impairment and Alzheimer's disease.
Journal of Alzheimer's disease : JAD
Tremblay C,Pilote M,Phivilay A,Emond V,Bennett DA,Calon F
MN1000 was used in western blot to quantify the abeta and tau pathologies in mild cognitive impairment and Alzheimer disease
Sat Dec 01 00:00:00 EST 2007
Tau in cerebrospinal fluid: a sensitive sandwich enzyme-linked immunosorbent assay using tyramide signal amplification.
Neuroscience letters
Yamamori H,Khatoon S,Grundke-Iqbal I,Blennow K,Ewers M,Hampel H,Iqbal K
MN1000 was used in ELISA to develop a novel ELISA assay for quantification of tau in cerebrospinal fluid
Thu May 17 00:00:00 EDT 2007
