Product References
Recurrent visceral leishmaniasis relapses in HIV co-infected patients are characterized by less efficient immune responses and higher parasite load.
iScience
Takele Y,Mulaw T,Adem E,Womersley R,Kaforou M,Franssen SU,Levin M,Taylor GP,Müller I,Cotton JA,Kropf P
12-9985-82 was used in Flow cytometry/Cell sorting to show that the relapse-free survival in patients with recurrent VL/HIV was shorter, that they had higher parasite load, lower weight gain, and lower recovery of all blood cell lineages.
Fri Feb 17 00:00:00 EST 2023
CD153/CD30 signaling promotes age-dependent tertiary lymphoid tissue expansion and kidney injury.
The Journal of clinical investigation
Sato Y,Oguchi A,Fukushima Y,Masuda K,Toriu N,Taniguchi K,Yoshikawa T,Cui X,Kondo M,Hosoi T,Komidori S,Shimizu Y,Fujita H,Jiang L,Kong Y,Yamanashi T,Seita J,Yamamoto T,Toyokuni S,Hamazaki Y,Hattori M,Yoshikai Y,Boor P,Floege J,Kawamoto H,Murakawa Y,Minato N,Yanagita M
Published figure using CD279 (PD-1) monoclonal antibody (Product # 12-9985-82) in Flow Cytometry
Tue Jan 18 00:00:00 EST 2022
CD4+ CTLs Act as a Key Effector Population for Allograft Rejection of MSCs in a Donor MHC-II Dependent Manner in Injured Liver.
Aging and disease
Shen S,Li Y,Jin M,Fan D,Pan R,Lin A,Chen Y,Xiang L,Zhao RC,Shao J
Published figure using CD279 (PD-1) monoclonal antibody (Product # 12-9985-82) in Flow Cytometry
Thu Dec 01 00:00:00 EST 2022
Ultrasound combined with nanobubbles promotes systemic anticancer immunity and augments anti-PD1 efficacy.
Journal for immunotherapy of cancer
Hu J,He J,Wang Y,Zhao Y,Fang K,Dong Y,Chen Y,Zhang Y,Zhang C,Wang H,Tan J,Wang J,Zi R,Liu C,Liang H,Guo Y,Ou J
Published figure using CD279 (PD-1) monoclonal antibody (Product # 12-9985-82) in Flow Cytometry
Tue Mar 01 00:00:00 EST 2022
PRDM1/BLIMP1 induces cancer immune evasion by modulating the USP22-SPI1-PD-L1 axis in hepatocellular carcinoma cells.
Nature communications
Li Q,Zhang L,You W,Xu J,Dai J,Hua D,Zhang R,Yao F,Zhou S,Huang W,Dai Y,Zhang Y,Baheti T,Qian X,Pu L,Xu J,Xia Y,Zhang C,Tang J,Wang X
12-9985-82 was used in Flow cytometry/Cell sorting to demonstrate that the PRDM1-USP22-SPI1 axis regulates PD-L1 levels, resulting in infiltrated CD8+ T cell exhaustion.
Mon Dec 12 00:00:00 EST 2022
PRDM1/BLIMP1 induces cancer immune evasion by modulating the USP22-SPI1-PD-L1 axis in hepatocellular carcinoma cells.
Nature communications
Li Q,Zhang L,You W,Xu J,Dai J,Hua D,Zhang R,Yao F,Zhou S,Huang W,Dai Y,Zhang Y,Baheti T,Qian X,Pu L,Xu J,Xia Y,Zhang C,Tang J,Wang X
12-9985-82 was used in Flow cytometry/Cell sorting to demonstrate that the PRDM1-USP22-SPI1 axis regulates PD-L1 levels, resulting in infiltrated CD8+ T cell exhaustion.
Mon Dec 12 00:00:00 EST 2022
Mobilizing phospholipids on tumor plasma membrane implicates phosphatidylserine externalization blockade for cancer immunotherapy.
Cell reports
Wang W,Wu S,Cen Z,Zhang Y,Chen Y,Huang Y,Cillo AR,Prokopec JS,Quarato G,Vignali DAA,Stewart-Ornstein J,Li S,Lu B,Gong YN
Published figure using CD279 (PD-1) monoclonal antibody (Product # 12-9985-82) in Flow Cytometry
Tue Nov 01 00:00:00 EDT 2022
Docetaxel remodels prostate cancer immune microenvironment and enhances checkpoint inhibitor-based immunotherapy.
Theranostics
Ma Z,Zhang W,Dong B,Xin Z,Ji Y,Su R,Shen K,Pan J,Wang Q,Xue W
12-9985-82 was used in Flow cytometry/Cell sorting to find that docetaxel activated the cGAS/STING pathway in prostate cancer, subsequently induced IFN signaling, resulting in lymphocytes infiltration.
Mon Jul 18 00:00:00 EDT 2022
Immunological factors, but not clinical features, predict visceral leishmaniasis relapse in patients co-infected with HIV.
Cell reports. Medicine
Takele Y,Mulaw T,Adem E,Shaw CJ,Franssen SU,Womersley R,Kaforou M,Taylor GP,Levin M,Müller I,Cotton JA,Kropf P
12-9985-82 was used in Flow Cytometry to identify three immunological markers associated with visceral leishmaniasis relapse in VL/HIV patients.
Tue Jan 18 00:00:00 EST 2022
Characterization of the spectrum of trivalent VAV1-mutation-driven tumours using a gene-edited mouse model.
Molecular oncology
Robles-Valero J,Fernández-Nevado L,Cuadrado M,Lorenzo-Martín LF,Fernández-Pisonero I,Abad A,Redín E,Montuenga L,Martín-Zanca D,Bigas A,Mallo M,Dosil M,Bustelo XR
12-9985-82 was used in Flow cytometry/Cell sorting to indicate that VAV1 mutations play critical, although highly cell-type-specific, roles in tumourigenesis.
Sat Oct 01 00:00:00 EDT 2022
NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity.
Nature immunology
Gu M,Zhou X,Sohn JH,Zhu L,Jie Z,Yang JY,Zheng X,Xie X,Yang J,Shi Y,Brightbill HD,Kim JB,Wang J,Cheng X,Sun SC
Published figure using CD279 (PD-1) monoclonal antibody (Product # 12-9985-82) in Flow Cytometry
Mon Feb 01 00:00:00 EST 2021
Cancer-associated mutations in VAV1 trigger variegated signaling outputs and T-cell lymphomagenesis.
The EMBO journal
Robles-Valero J,Fernández-Nevado L,Lorenzo-Martín LF,Cuadrado M,Fernández-Pisonero I,Rodríguez-Fdez S,Astorga-Simón EN,Abad A,Caloto R,Bustelo XR
Published figure using CD279 (PD-1) monoclonal antibody (Product # 12-9985-82) in Flow Cytometry
Mon Nov 15 00:00:00 EST 2021
Histone deacetylase 3 represses cholesterol efflux during CD4+ T-cell activation.
eLife
Wilfahrt D,Philips RL,Lama J,Kizerwetter M,Shapiro MJ,McCue SA,Kennedy MM,Rajcula MJ,Zeng H,Shapiro VS
Published figure using CD279 (PD-1) monoclonal antibody (Product # 12-9985-82) in Flow Cytometry
Thu Dec 02 00:00:00 EST 2021
Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade.
JCI insight
Ferrere G,Tidjani Alou M,Liu P,Goubet AG,Fidelle M,Kepp O,Durand S,Iebba V,Fluckiger A,Daillère R,Thelemaque C,Grajeda-Iglesias C,Alves Costa Silva C,Aprahamian F,Lefevre D,Zhao L,Ryffel B,Colomba E,Arnedos M,Drubay D,Rauber C,Raoult D,Asnicar F,Spector T,Segata N,Derosa L,Kroemer G,Zitvogel L
Published figure using CD279 (PD-1) monoclonal antibody (Product # 12-9985-82) in Flow Cytometry
Mon Jan 25 00:00:00 EST 2021
PTENα functions as an immune suppressor and promotes immune resistance in PTEN-mutant cancer.
Nature communications
Sun Y,Lu D,Yin Y,Song J,Liu Y,Hao W,Qi F,Zhang G,Zhang X,Liu L,Lin Z,Liang H,Zhao X,Jin Y,Yin Y
Published figure using CD279 (PD-1) monoclonal antibody (Product # 12-9985-82) in Flow Cytometry
Thu Aug 26 00:00:00 EDT 2021
Stearoyl-CoA Desaturase-Mediated Monounsaturated Fatty Acid Availability Supports Humoral Immunity.
Cell reports
Zhou X,Zhu X,Li C,Li Y,Ye Z,Shapiro VS,Copland JA,Hitosugi T,Bernlohr DA,Sun J,Zeng H
Published figure using CD279 (PD-1) monoclonal antibody (Product # 12-9985-82) in Flow Cytometry
Tue Jan 05 00:00:00 EST 2021
Graded RhoA GTPase Expression in Treg Cells Distinguishes Tumor Immunity From Autoimmunity.
Frontiers in immunology
Kalim KW,Yang JQ,Modur V,Nguyen P,Li Y,Zheng Y,Guo F
Published figure using CD279 (PD-1) monoclonal antibody (Product # 12-9985-82) in Flow Cytometry
Tue Jan 11 00:00:00 EST 2022
USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade.
Nature communications
Yang Z,Xu G,Wang B,Liu Y,Zhang L,Jing T,Tang M,Xu X,Jiao K,Xiang L,Fu Y,Tang D,Zhang X,Jin W,Zhuang G,Zhao X,Liu Y
12-9985-82 was used in Flow Cytometry to show that the deubiquitinase USP12 is commonly downregulated in the KrasG12D-driven mouse lung tumour and human non-small cell lung cancer owing to the activation of AKT-mTOR signalling.
Wed Aug 11 00:00:00 EDT 2021
Activation of regulatory T cells triggers specific changes in glycosylation associated with Siglec-1-dependent inflammatory responses.
Wellcome open research
Wu G,Murugesan G,Nagala M,McCraw A,Haslam SM,Dell A,Crocker PR
Published figure using CD279 (PD-1) monoclonal antibody (Product # 12-9985-82) in Flow Cytometry
Tue Mar 01 00:00:00 EST 2022
Serum HBsAg clearance has minimal impact on CD8+ T cell responses in mouse models of HBV infection.
The Journal of experimental medicine
Fumagalli V,Di Lucia P,Venzin V,Bono EB,Jordan R,Frey CR,Delaney W,Chisari FV,Guidotti LG,Iannacone M
Published figure using CD279 (PD-1) monoclonal antibody (Product # 12-9985-82) in Flow Cytometry
Mon Nov 02 00:00:00 EST 2020
B cells are sufficient to prime the dominant CD4+ Tfh response to Plasmodium infection.
The Journal of experimental medicine
Arroyo EN,Pepper M
Published figure using CD279 (PD-1) monoclonal antibody (Product # 12-9985-82) in Flow Cytometry
Mon Feb 03 00:00:00 EST 2020
Targeting CMTM6 Suppresses Stem Cell-Like Properties and Enhances Antitumor Immunity in Head and Neck Squamous Cell Carcinoma.
Cancer immunology research
Chen L,Yang QC,Li YC,Yang LL,Liu JF,Li H,Xiao Y,Bu LL,Zhang WF,Sun ZJ
12-9985 was used in Flow cytometry/Cell sorting to investigate the correlation of CMTM6 expression, a regulator of PD-L1 expression, with the prognosis of patients with Head and Neck Squamous Cell Carcinoma.
Sat Feb 01 00:00:00 EST 2020
In Situ Therapeutic Cancer Vaccination with an Oncolytic Virus Expressing Membrane-Tethered IL-2.
Molecular therapy oncolytics
Liu W,Dai E,Liu Z,Ma C,Guo ZS,Bartlett DL
12-9985 was used in Flow cytometry/Cell sorting to establish in situ anticancer immunotherapy regimens.
Fri Jun 26 00:00:00 EDT 2020
Inhibition of the Wnt/β-catenin pathway enhances antitumor immunity in ovarian cancer.
Therapeutic advances in medical oncology
Doo DW,Meza-Perez S,Londoño AI,Goldsberry WN,Katre AA,Boone JD,Moore DJ,Hudson CT,Betella I,McCaw TR,Gangrade A,Bao R,Luke JJ,Yang ES,Birrer MJ,Starenki D,Cooper SJ,Buchsbaum DJ,Norian LA,Randall TD,Arend RC
12-9985 was used in Flow cytometry/Cell sorting to determine whether WNT974 would impair tumor growth, affect gene expression patterns, and improve the immune response in human and murine ovarian cancer models.
Thu Apr 14 00:00:00 EDT 2022
Inhibition of the Wnt/β-catenin pathway enhances antitumor immunity in ovarian cancer.
Therapeutic advances in medical oncology
Doo DW,Meza-Perez S,Londoño AI,Goldsberry WN,Katre AA,Boone JD,Moore DJ,Hudson CT,Betella I,McCaw TR,Gangrade A,Bao R,Luke JJ,Yang ES,Birrer MJ,Starenki D,Cooper SJ,Buchsbaum DJ,Norian LA,Randall TD,Arend RC
12-9985 was used in Flow cytometry/Cell sorting to determine whether WNT974 would impair tumor growth, affect gene expression patterns, and improve the immune response in human and murine ovarian cancer models.
Thu Apr 14 00:00:00 EDT 2022
Repurposing the psoriasis drug Oxarol to an ointment adjuvant for the influenza vaccine.
International immunology
Sato R,Makino-Okamura C,Lin Q,Wang M,Shoemaker JE,Kurosaki T,Fukuyama H
12-9985 was used in Flow cytometry/Cell sorting to report in a mouse model that the psoriasis drug Oxarol ointment is a highly effective vaccine adjuvant.
Tue Jul 28 00:00:00 EDT 2020
Gene silencing of indoleamine 2,3-dioxygenase 1 inhibits lung cancer growth by suppressing T-cell exhaustion.
Oncology letters
Shang K,Wang Z,Hu Y,Huang Y,Yuan K,Yu Y
Published figure using CD279 (PD-1) monoclonal antibody (Product # 12-9985-82) in Flow Cytometry
Mon Jun 01 00:00:00 EDT 2020
Lysosomal Acid Lipase Is Required for Donor T Cells to Induce Graft-versus-Host Disease.
Cell reports
Nguyen HD,Ticer T,Bastian D,Kuril S,Li H,Du H,Yan C,Yu XZ
12-9985 was used in Flow cytometry/Cell sorting to reveal the role of LAL in T cell alloresponse and pathogenicity and validates LAL as a target for controlling GVHD and tumor relapse after allo-HCT.
Tue Oct 27 00:00:00 EDT 2020
Lysosomal Acid Lipase Is Required for Donor T Cells to Induce Graft-versus-Host Disease.
Cell reports
Nguyen HD,Ticer T,Bastian D,Kuril S,Li H,Du H,Yan C,Yu XZ
12-9985 was used in Flow cytometry/Cell sorting to reveal the role of LAL in T cell alloresponse and pathogenicity and validates LAL as a target for controlling GVHD and tumor relapse after allo-HCT.
Tue Oct 27 00:00:00 EDT 2020
5-Azacytidine Potentiates Anti-tumor Immunity in a Model of Pancreatic Ductal Adenocarcinoma.
Frontiers in immunology
Ebelt ND,Zuniga E,Johnson BL,Diamond DJ,Manuel ER
Published figure using CD279 (PD-1) monoclonal antibody (Product # 12-9985-82) in Flow Cytometry
Fri Mar 26 00:00:00 EDT 2021
The Selenoprotein MsrB1 Instructs Dendritic Cells to Induce T-Helper 1 Immune Responses.
Antioxidants (Basel, Switzerland)
Lee HJ,Park JS,Yoo HJ,Lee HM,Lee BC,Kim JH
Published figure using CD279 (PD-1) monoclonal antibody (Product # 12-9985-82) in Flow Cytometry
Tue Oct 20 00:00:00 EDT 2020
Inhibiting WNT Ligand Production for Improved Immune Recognition in the Ovarian Tumor Microenvironment.
Cancers
Goldsberry WN,Meza-Perez S,Londoño AI,Katre AA,Mott BT,Roane BM,Goel N,Wall JA,Cooper SJ,Norian LA,Randall TD,Birrer MJ,Arend RC
12-9985 was used in Flow cytometry/Cell sorting to study Wnt activity within the microenvironment of ovarian tumors.
Tue Mar 24 00:00:00 EDT 2020
Microglial A20 Protects the Brain from CD8 T-Cell-Mediated Immunopathology.
Cell reports
Mohebiany AN,Ramphal NS,Karram K,Di Liberto G,Novkovic T,Klein M,Marini F,Kreutzfeldt M,Härtner F,Lacher SM,Bopp T,Mittmann T,Merkler D,Waisman A
12-9985 was used in Flow cytometry/Cell sorting to investigate the role of tumor-necrosis-factor-alpha-induced protein 3 in the central nervous system (CNS).
Tue Feb 04 00:00:00 EST 2020
Endogenous retroviral proteins provide an immunodominant but not requisite antigen in a murine immunotherapy tumor model.
Oncoimmunology
Ye X,Waite JC,Dhanik A,Gupta N,Zhong M,Adler C,Malahias E,Ni M,Wei Y,Gurer C,Zhang W,Macdonald LE,Murphy AJ,Sleeman MA,Skokos D
Published figure using CD279 (PD-1) monoclonal antibody (Product # 12-9985-82) in Flow Cytometry
Wed May 13 00:00:00 EDT 2020
Programming Multifaceted Pulmonary T Cell Immunity by Combination Adjuvants.
Cell reports. Medicine
Marinaik CB,Kingstad-Bakke B,Lee W,Hatta M,Sonsalla M,Larsen A,Neldner B,Gasper DJ,Kedl RM,Kawaoka Y,Suresh M
12-9985 was used in Flow cytometry/Cell sorting to provide further insights into vaccine-induced multifaceted mucosal T cell immunity with implications in the development of vaccines against respiratorypathogens, including influenza virus and SARS-CoV-2.
Tue Sep 22 00:00:00 EDT 2020
SLAMF6 deficiency augments tumor killing and skews toward an effector phenotype revealing it as a novel T cell checkpoint.
eLife
Hajaj E,Eisenberg G,Klein S,Frankenburg S,Merims S,Ben David I,Eisenhaure T,Henrickson SE,Villani AC,Hacohen N,Abudi N,Abramovich R,Cohen JE,Peretz T,Veillette A,Lotem M
12-9985-82 was used in Flow Cytometry to support the notion that SLAMF6 is an inhibitory immune receptor whose absence enables powerful CD8+ T cells to eradicate tumors.
Tue Mar 03 00:00:00 EST 2020
Cyclooxygenase-1 Regulates the Development of Follicular Th Cells via Prostaglandin E2.
Journal of immunology (Baltimore, Md. : 1950)
Liu T,Yang Q,Cao YJ,Yuan WM,Lei AH,Zhou P,Zhou W,Liu YD,Shi MH,Yang Q,Tang JY,Wang HK,Zhang H,Yu Y,Zhou J
12-9985-82 was used in Flow Cytometry to indicate that COX-1 plays an important role in the development of TFH cells.
Thu Aug 15 00:00:00 EDT 2019
Anti-PD-1 Antibody Administration following Hip Fracture Surgery Reverses Immune Dysfunction and Decreases Susceptibility to Infection.
Mediators of inflammation
Zhang H,Chen C,He J,Zhang J,Liu Z,Sun T
12-9985 was used in Flow cytometry/Cell sorting to assess expression of programmed death-1 (PD-1) and inflammatory status after hip fracture surgery in aged mice and to evaluate the effect of anti-PD-1 antibody intervention.
Mon Sep 02 00:00:00 EDT 2019
PD-1 inhibitors dependent CD8+ T cells inhibit mouse colon cancer cell metastasis.
OncoTargets and therapy
Gao CE,Zhang M,Song Q,Dong J
12-9985-82 was used in Flow Cytometry to investigate the function of PD-1 inhibitor on the metastasisi of mouse colon cancer cells.
Mon Apr 11 00:00:00 EDT 2022
Combination PD-1 and PD-L1 Blockade Promotes Durable Neoantigen-Specific T Cell-Mediated Immunity in Pancreatic Ductal Adenocarcinoma.
Cell reports
Burrack AL,Spartz EJ,Raynor JF,Wang I,Olson M,Stromnes IM
Published figure using CD279 (PD-1) monoclonal antibody (Product # 12-9985-82) in Flow Cytometry
Tue Aug 20 00:00:00 EDT 2019
Glucocorticoid Receptor-Deficient Foxp3+ Regulatory T Cells Fail to Control Experimental Inflammatory Bowel Disease.
Frontiers in immunology
Rocamora-Reverte L,Tuzlak S,von Raffay L,Tisch M,Fiegl H,Drach M,Reichardt HM,Villunger A,Tischner D,Wiegers GJ
12-9985 was used in Flow cytometry/Cell sorting to generate mice with a specific deletion of the glucocorticoid receptor (GR) in Foxp3+ Treg cells.
Thu Sep 10 00:00:00 EDT 2020
Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells.
Cell
Gaya M,Barral P,Burbage M,Aggarwal S,Montaner B,Warren Navia A,Aid M,Tsui C,Maldonado P,Nair U,Ghneim K,Fallon PG,Sekaly RP,Barouch DH,Shalek AK,Bruckbauer A,Strid J,Batista FD
Published figure using CD279 (PD-1) monoclonal antibody (Product # 12-9985-82) in Flow Cytometry
Thu Jan 25 00:00:00 EST 2018
Activation of p53 in Immature Myeloid Precursor Cells Controls Differentiation into Ly6c+CD103+ Monocytic Antigen-Presenting Cells in Tumors.
Immunity
Sharma MD,Rodriguez PC,Koehn BH,Baban B,Cui Y,Guo G,Shimoda M,Pacholczyk R,Shi H,Lee EJ,Xu H,Johnson TS,He Y,Mergoub T,Venable C,Bronte V,Wolchok JD,Blazar BR,Munn DH
12-9985 was used in Flow cytometry/Cell sorting to show that during immunotherapy large numbers of cells expressing CD103 arose in murine tumours via direct differentiation of Ly6c+ monocytic precursors.
Tue Jan 16 00:00:00 EST 2018
Plasma cell output from germinal centers is regulated by signals from Tfh and stromal cells.
The Journal of experimental medicine
Zhang Y,Tech L,George LA,Acs A,Durrett RE,Hess H,Walker LSK,Tarlinton DM,Fletcher AL,Hauser AE,Toellner KM
12-9985 was used in Flow cytometry/Cell sorting to show that from the earliest stages of the germinal centre response, plasmablasts emerge at the GC-T zone interface (GTI).
Mon Apr 02 00:00:00 EDT 2018
Complement Activation via a C3a Receptor Pathway Alters CD4+ T Lymphocytes and Mediates Lung Cancer Progression.
Cancer research
Kwak JW,Laskowski J,Li HY,McSharry MV,Sippel TR,Bullock BL,Johnson AM,Poczobutt JM,Neuwelt AJ,Malkoski SP,Weiser-Evans MC,Lambris JD,Clambey ET,Thurman JM,Nemenoff RA
12-9985 was used in Flow cytometry/Cell sorting to study the mechanism relating complement activation to tumour progression in multiple immunocompetent orthotopic models of lung cancer.
Mon Jan 01 00:00:00 EST 2018
Trichinella spiralis Infection Mitigates Collagen-Induced Arthritis via Programmed Death 1-Mediated Immunomodulation.
Frontiers in immunology
Cheng Y,Zhu X,Wang X,Zhuang Q,Huyan X,Sun X,Huang J,Zhan B,Zhu X
Mon Jan 28 00:00:00 EST 2019
IgG Responses to Porins and Lipopolysaccharide within an Outer Membrane-Based Vaccine against Nontyphoidal Salmonella Develop at Discordant Rates.
mBio
Schager AE,Dominguez-Medina CC,Necchi F,Micoli F,Goh YS,Goodall M,Flores-Langarica A,Bobat S,Cook CNL,Arcuri M,Marini A,King LDW,Morris FC,Anderson G,Toellner KM,Henderson IR,López-Macías C,MacLennan CA,Cunningham AF
12-9985 was used in Flow cytometry/Cell sorting to study how antibody responses to bacterial antigens develop and how vaccines like generalised modules for membrane antigens can work and help prevent infection.
Tue Mar 06 00:00:00 EST 2018
Tissue-Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression.
Immunity
Zhu Y,Herndon JM,Sojka DK,Kim KW,Knolhoff BL,Zuo C,Cullinan DR,Luo J,Bearden AR,Lavine KJ,Yokoyama WM,Hawkins WG,Fields RC,Randolph GJ,DeNardo DG
12-9985 was used in Flow cytometry/Cell sorting to uncover the heterogeneity of TAM origin and functions and could provide therapeutic insight for PDAC treatment.
Tue Aug 15 00:00:00 EDT 2017
Oncolytic Adenovirus and Tumor-Targeting Immune Modulatory Therapy Improve Autologous Cancer Vaccination.
Cancer research
Jiang H,Rivera-Molina Y,Gomez-Manzano C,Clise-Dwyer K,Bover L,Vence LM,Yuan Y,Lang FF,Toniatti C,Hossain MB,Fueyo J
Published figure using CD279 (PD-1) monoclonal antibody (Product # 12-9985-82) in Flow Cytometry
Sat Jul 15 00:00:00 EDT 2017
Cblb-deficient T cells are less susceptible to PD-L1-mediated inhibition.
Oncotarget
Peer S,Baier G,Gruber T
12-9985 was used in Flow cytometry/Cell sorting to show that Cblb-/- T cells are less susceptible to PD-L1-mediated suppression of T cell proliferation and IFNγ secretion.
Tue Jun 27 00:00:00 EDT 2017
Cblb-deficient T cells are less susceptible to PD-L1-mediated inhibition.
Oncotarget
Peer S,Baier G,Gruber T
12-9985 was used in Flow cytometry/Cell sorting to show that Cblb-/- T cells are less susceptible to PD-L1-mediated suppression of T cell proliferation and IFNγ secretion.
Tue Jun 27 00:00:00 EDT 2017
Therapeutic efficacy of combined vaccination against tumor pericyte-associated antigens DLK1 and DLK2 in mice.
Oncoimmunology
Fabian KP,Chi-Sabins N,Taylor JL,Fecek R,Weinstein A,Storkus WJ
Published figure using CD279 (PD-1) monoclonal antibody (Product # 12-9985-82) in Flow Cytometry
Tue Jan 12 00:00:00 EST 2021
Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity.
Nature communications
Zamarin D,Holmgaard RB,Ricca J,Plitt T,Palese P,Sharma P,Merghoub T,Wolchok JD,Allison JP
Published figure using CD279 (PD-1) monoclonal antibody (Product # 12-9985-82) in Flow Cytometry
Mon Feb 13 00:00:00 EST 2017
Maternal-Derived Hepatitis B Virus e Antigen Alters Macrophage Function in Offspring to Drive Viral Persistence after Vertical Transmission.
Immunity
Tian Y,Kuo CF,Akbari O,Ou JH
Tue May 17 00:00:00 EDT 2016
Concomitant targeting of programmed death-1 (PD-1) and CD137 improves the efficacy of radiotherapy in a mouse model of human BRAFV600-mutant melanoma.
Cancer immunology, immunotherapy : CII
Kroon P,Gadiot J,Peeters M,Gasparini A,Deken MA,Yagita H,Verheij M,Borst J,Blank CU,Verbrugge I
12-9985 was used in Flow cytometry/Cell sorting to examine the extent to which T cell co-stimulation and/or stereotactic body radiation therapy could enhance the therapeutic efficacy of T cell checkpoint blockade.
Wed Jun 01 00:00:00 EDT 2016
Helios Controls a Limited Subset of Regulatory T Cell Functions.
Journal of immunology (Baltimore, Md. : 1950)
Sebastian M,Lopez-Ocasio M,Metidji A,Rieder SA,Shevach EM,Thornton AM
12-9985 was used in Flow cytometry/Cell sorting to determine the beneficial effects of the transcription factor, Helios, for Treg maintenance, differentiation, and survival.
Fri Jan 01 00:00:00 EST 2016
Growth and metastasis of lung adenocarcinoma is potentiated by BMP4-mediated immunosuppression.
Oncoimmunology
Chen L,Yi X,Goswami S,Ahn YH,Roybal JD,Yang Y,Diao L,Peng D,Peng D,Fradette JJ,Wang J,Byers LA,Kurie JM,Ullrich SE,Qin FX,Gibbons DL
Published figure using CD279 (PD-1) monoclonal antibody (Product # 12-9985-82) in Flow Cytometry
Tue Jan 12 00:00:00 EST 2021
The stress kinase GCN2 does not mediate suppression of antitumor T cell responses by tryptophan catabolism in experimental melanomas.
Oncoimmunology
Sonner JK,Deumelandt K,Ott M,Thomé CM,Rauschenbach KJ,Schulz S,Munteanu B,Mohapatra S,Adam I,Hofer AC,Feuerer M,Opitz CA,Hopf C,Wick W,Platten M
Published figure using CD279 (PD-1) monoclonal antibody (Product # 12-9985-82) in Flow Cytometry
Tue Jan 12 00:00:00 EST 2021
Heme oxygenase-1 protects regulatory T cells from hypoxia-induced cellular stress in an experimental mouse brain tumor model.
Journal of neuroimmunology
Dey M,Chang AL,Wainwright DA,Ahmed AU,Han Y,Balyasnikova IV,Lesniak MS
12-9985 was used in Flow cytometry/Cell sorting to assess the benefit of higher HO1 expression in Tregs in glioma.
Wed Jan 15 00:00:00 EST 2014
Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression.
Nature communications
Chen L,Gibbons DL,Goswami S,Cortez MA,Ahn YH,Byers LA,Zhang X,Yi X,Dwyer D,Lin W,Diao L,Wang J,Roybal J,Patel M,Ungewiss C,Peng D,Antonia S,Mediavilla-Varela M,Robertson G,Suraokar M,Welsh JW,Erez B,Wistuba II,Chen L,Peng D,Wang S,Ullrich SE,Heymach JV,Kurie JM,Qin FX
12-9985 was used in Flow cytometry/Cell sorting to reveal a link between EMT and T-cell dysfunction and show that ZEB1 promotes metastasis through a cell non-autonomous mechanism.
Tue Oct 28 00:00:00 EDT 2014
Intercellular communication through contacts between continuous pseudopodial extensions in a macrophage-like cell line.
Cell communication & adhesion
Arrevillaga-Boni G,Hernández-Ruiz M,Castillo EC,Ortiz-Navarrete V
12-9985 was used in Flow cytometry/Cell sorting to investigate direct intercellular communication in a macrophage-like cell line, showing communication through contacts between continuous pseudopodial extensions.
Fri Aug 01 00:00:00 EDT 2014
Blockade of the negative co-stimulatory molecules PD-1 and CTLA-4 improves survival in primary and secondary fungal sepsis.
Critical care (London, England)
Chang KC,Burnham CA,Compton SM,Rasche DP,Mazuski RJ,McDonough JS,Unsinger J,Korman AJ,Green JM,Hotchkiss RS
12-9985 was used in Flow cytometry/Cell sorting to demonstrate the potential for therapy with anti-PD-1 in patients with life-threatening sepsis.
Sat May 11 00:00:00 EDT 2013
Th2 cell-intrinsic hypo-responsiveness determines susceptibility to helminth infection.
PLoS pathogens
van der Werf N,Redpath SA,Azuma M,Yagita H,Taylor MD
12-9985 was used in Flow cytometry/Cell sorting to demonstrate that during chronic Litomosoides sigmodontis infection, CD4(+) Th2 cells are conditioned towards an intrinsically hypo-responsive phenotype.
Fri Mar 01 00:00:00 EST 2013
Intrinsic T- and B-cell defects impair T-cell-dependent antibody responses in mice lacking the actin-bundling protein L-plastin.
European journal of immunology
Todd EM,Deady LE,Morley SC
12-9985 was used in Flow cytometry/Cell sorting to study the role of L-plastin in the modulation of both T- and B-cell immune responses.
Mon Jul 01 00:00:00 EDT 2013
PD-1 regulates T cell proliferation in a tissue and subset-specific manner during normal mouse pregnancy.
Immunological investigations
Shepard MT,Bonney EA
12-9985 was used in Flow cytometry/Cell sorting to suggest that there is a state of dynamic T cell homeostasis during pregnancy which is partially supported by PD-1 signalling.
Tue Feb 11 00:00:00 EST 2014
Investigating the role for IL-21 in rabies virus vaccine-induced immunity.
PLoS neglected tropical diseases
Dorfmeier CL,Tzvetkov EP,Gatt A,McGettigan JP
12-9985 was used in Flow cytometry/Cell sorting to study the effects of knocking out IL-21 on the development of vaccine-induced immunity against rabies.
Wed Aug 28 00:00:00 EDT 2013
IFNγ induces monopoiesis and inhibits neutrophil development during inflammation.
Blood
de Bruin AM,Libregts SF,Valkhof M,Boon L,Touw IP,Nolte MA
12-9985 was used in Flow cytometry/Cell sorting to demonstrate that the pro-inflammatory cytokine IFNγ is involved in orchestrating inflammation-induced myelopoiesis.
Thu Feb 09 00:00:00 EST 2012
Dendritic cells tolerized with adenosine A₂AR agonist attenuate acute kidney injury.
The Journal of clinical investigation
Li L,Huang L,Ye H,Song SP,Bajwa A,Lee SJ,Moser EK,Jaworska K,Kinsey GR,Day YJ,Linden J,Lobo PI,Rosin DL,Okusa MD
12-9985 was used in Flow cytometry/Cell sorting to show that mice with A2AR-deficient dendritic cells are more susceptible to kidney ischemia/reperfusion injury.
Thu Nov 01 00:00:00 EDT 2012
Mechanisms of indirect acute lung injury: a novel role for the coinhibitory receptor, programmed death-1.
Annals of surgery
Monaghan SF,Thakkar RK,Heffernan DS,Huang X,Chung CS,Lomas-Neira J,Cioffi WG,Ayala A
12-9985 was used in Flow cytometry/Cell sorting to investigate how PD-1 expression contributes to mortality after the induction of indirect-acute lung injury.
Sun Jan 01 00:00:00 EST 2012
On the role of regulatory T cells during viral-induced inflammatory lesions.
Journal of immunology (Baltimore, Md. : 1950)
Veiga-Parga T,Suryawanshi A,Mulik S,Giménez F,Sharma S,Sparwasser T,Rouse BT
12-9985 was used in Flow cytometry/Cell sorting to investigate the role of Foxp3(+)CD4(+) Tregs during ongoing inflammatory reactions in ocular HSV-1 infection.
Sat Dec 15 00:00:00 EST 2012
Optimal isolation of functional Foxp3+ induced regulatory T cells using DEREG mice.
PloS one
Baru AM,Untucht C,Ganesh V,Hesse C,Mayer CT,Sparwasser T
12-9985 was used in Flow cytometry/Cell sorting to define culture conditions for efficient generation of eGFP(+)Foxp3(+) iTregs by use of DEREG mice.
Thu Feb 14 00:00:00 EST 2013
Helios is associated with CD4 T cells differentiating to T helper 2 and follicular helper T cells in vivo independently of Foxp3 expression.
PloS one
Serre K,Bénézech C,Desanti G,Bobat S,Toellner KM,Bird R,Chan S,Kastner P,Cunningham AF,Maclennan IC,Mohr E
12-9985 was used in Flow cytometry/Cell sorting to reveal the selective upregulation of Helios during Th2 and TFh responses to alum-protein vaccines.
Mon Oct 17 00:00:00 EDT 2011
PD-L1 blockade improves survival in experimental sepsis by inhibiting lymphocyte apoptosis and reversing monocyte dysfunction.
Critical care (London, England)
Zhang Y,Zhou Y,Lou J,Li J,Bo L,Zhu K,Wan X,Deng X,Cai Z
12-9985 was used in Flow cytometry/Cell sorting to investigate the function and mechanism of action of PD-L1 in experimental sepsis in mice.
Thu Jan 26 00:00:00 EST 2012
Partial restoration of T-cell function in aged mice by in vitro blockade of the PD-1/ PD-L1 pathway.
Aging cell
Lages CS,Lewkowich I,Sproles A,Wills-Karp M,Chougnet C
12-9985 was used in Flow cytometry/Cell sorting to suggest that blockade of the PD-1/PD-L1 is not likely to be efficient at restoring exhausted T-cell responses in aged hosts.
Fri Oct 01 00:00:00 EDT 2010
Costimulator B7-DC attenuates strong Th2 responses induced by Nippostrongylus brasiliensis.
Journal of immunology (Baltimore, Md. : 1950)
Ishiwata K,Watanabe N,Guo M,Tomihara K,Brumlik MJ,Yagita H,Pardoll D,Chen L,Shin T
12-9985 was used in Flow cytometry/Cell sorting to demonstrate that the inhibition of Th2 responses by B7-DC occurs independently of programmed death 1 but conceivably acts through an as yet unknown alternative receptor that enhances Th1 responses.
Mon Feb 15 00:00:00 EST 2010
In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression.
The Journal of experimental medicine
Webster KE,Walters S,Kohler RE,Mrkvan T,Boyman O,Surh CD,Grey ST,Sprent J
12-9985 was used in Flow cytometry/Cell sorting to study the role of T reg cells in the induction of resistance to EAE and long term acceptance of islet allografts.
Mon Apr 13 00:00:00 EDT 2009
Maternal PD-1 regulates accumulation of fetal antigen-specific CD8+ T cells in pregnancy.
Journal of reproductive immunology
Taglauer ES,Yankee TM,Petroff MG
12-9985 was used in Flow cytometry/Cell sorting to investigate the role of the PD-1/B7-H1 pathway in maternal tolerance of the fetus.
Mon Jun 01 00:00:00 EDT 2009
Programmed death ligand 1 regulates a critical checkpoint for autoimmune myocarditis and pneumonitis in MRL mice.
Journal of immunology (Baltimore, Md. : 1950)
Lucas JA,Menke J,Rabacal WA,Schoen FJ,Sharpe AH,Kelley VR
12-9985 was used in Flow cytometry/Cell sorting to compare kidney and systemic illness in PD-L1 null and PD-L1 intact mouse models of lupus.
Fri Aug 15 00:00:00 EDT 2008
The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice.
The Journal of experimental medicine
Ansari MJ,Salama AD,Chitnis T,Smith RN,Yagita H,Akiba H,Yamazaki T,Azuma M,Iwai H,Khoury SJ,Auchincloss H,Sayegh MH
Mon Jul 07 00:00:00 EDT 2003
The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice.
The Journal of experimental medicine
Ansari MJ,Salama AD,Chitnis T,Smith RN,Yagita H,Akiba H,Yamazaki T,Azuma M,Iwai H,Khoury SJ,Auchincloss H,Sayegh MH
Mon Jul 07 00:00:00 EDT 2003
The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice.
The Journal of experimental medicine
Ansari MJ,Salama AD,Chitnis T,Smith RN,Yagita H,Akiba H,Yamazaki T,Azuma M,Iwai H,Khoury SJ,Auchincloss H,Sayegh MH
Mon Jul 07 00:00:00 EDT 2003
