Product References
HIF-1 regulates pathogenic cytotoxic T cells in lupus skin disease.
JCI insight
Little AJ,Chen PM,Vesely MD,Khan RN,Fiedler J,Garritano J,Maisha FI,McNiff JM,Craft J
12-0453-82 was used in Flow cytometry/Cell sorting to demonstrate in human CLE tissue that the T cell-rich inflammatory infiltrate exhibited increased amounts of HIF-1 and a cytotoxic signature.
Tue Aug 22 00:00:00 EDT 2023
Tet-mediated DNA demethylation regulates specification of hematopoietic stem and progenitor cells during mammalian embryogenesis.
Science advances
Ma L,Tang Q,Gao X,Lee J,Lei R,Suzuki M,Zheng D,Ito K,Frenette PS,Dawlaty MM
Published figure using CD45.1 monoclonal antibody (Product # 12-0453-82) in Flow Cytometry
Fri Mar 04 00:00:00 EST 2022
Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation.
Nature immunology
Rivas MA,Meydan C,Chin CR,Challman MF,Kim D,Bhinder B,Kloetgen A,Viny AD,Teater MR,McNally DR,Doane AS,Béguelin W,Fernández MTC,Shen H,Wang X,Levine RL,Chen Z,Tsirigos A,Elemento O,Mason CE,Melnick AM
Published figure using CD45.1 monoclonal antibody (Product # 12-0453-82) in Flow Cytometry
Mon Feb 01 00:00:00 EST 2021
Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions.
The Journal of experimental medicine
Ho TT,Dellorusso PV,Verovskaya EV,Bakker ST,Flach J,Smith LK,Ventura PB,Lansinger OM,Hérault A,Zhang SY,Kang YA,Mitchell CA,Villeda SA,Passegué E
Published figure using CD45.1 monoclonal antibody (Product # 12-0453-82) in Flow Cytometry
Mon Jul 05 00:00:00 EDT 2021
Differentiation of fetal hematopoietic stem cells requires ARID4B to restrict autocrine KITLG/KIT-Src signaling.
Cell reports
Young IC,Wu B,Andricovich J,Chuang ST,Li R,Tzatsos A,Wu RC,Wu MY
Published figure using CD45.1 monoclonal antibody (Product # 12-0453-82) in Flow Cytometry
Tue Nov 23 00:00:00 EST 2021
Development of a VRC01-class germline targeting immunogen derived from anti-idiotypic antibodies.
Cell reports
Seydoux E,Wan YH,Feng J,Wall A,Aljedani S,Homad LJ,MacCamy AJ,Weidle C,Gray MD,Brumage L,Taylor JJ,Pancera M,Stamatatos L,McGuire AT
Published figure using CD45.1 monoclonal antibody (Product # 12-0453-82) in Flow Cytometry
Tue May 04 00:00:00 EDT 2021
Ddb1 Is Essential for the Expansion of CD4+ Helper T Cells by Regulating Cell Cycle Progression and Cell Death.
Frontiers in immunology
Yang L,Chen W,Li L,Xiao Y,Fan S,Zhang Q,Xia T,Li M,Hong Y,Zhao T,Li Q,Liu WH,Xiao N
Published figure using CD45.1 monoclonal antibody (Product # 12-0453-82) in Flow Cytometry
Mon Dec 20 00:00:00 EST 2021
Brain endothelial PTEN/AKT/NEDD4-2/MFSD2A axis regulates blood-brain barrier permeability.
Cell reports
Cui Y,Wang Y,Song X,Ning H,Zhang Y,Teng Y,Wang J,Yang X
12-0453-82 was used in Flow Cytometry to reveal the essential physiological function of the PTEN/AKT/NEDD4-2/MFSD2A axis in the regulation of BBB permeability.
Tue Jul 06 00:00:00 EDT 2021
Niche-Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic Redundancy.
Cell
Wu L,Hollinshead KER,Hao Y,Au C,Kroehling L,Ng C,Lin WY,Li D,Silva HM,Shin J,Lafaille JJ,Possemato R,Pacold ME,Papagiannakopoulos T,Kimmelman AC,Satija R,Littman DR
12-0453-82 was used in Flow Cytometry to suggest that inhibiting glycolysis by targeting Gpi1 could be an effective therapeutic strategy with minimum toxicity for Th17-mediated autoimmune diseases, and, more generally, that metabolic redundancies can be exploited for selective targeting of disease processes.
Thu Aug 06 00:00:00 EDT 2020
C/EBPα and GATA-2 Mutations Induce Bilineage Acute Erythroid Leukemia through Transformation of a Neomorphic Neutrophil-Erythroid Progenitor.
Cancer cell
Di Genua C,Valletta S,Buono M,Stoilova B,Sweeney C,Rodriguez-Meira A,Grover A,Drissen R,Meng Y,Beveridge R,Aboukhalil Z,Karamitros D,Belderbos ME,Bystrykh L,Thongjuea S,Vyas P,Nerlov C
12-0453 was used in Flow cytometry/Cell sorting to show that combined biallelic Cebpa and Gata2 zinc finger-1 (ZnF1) mutations cooperatively induce bilineage AEL, and that the major leukemia-initiating cell (LIC) population has a neutrophil-monocyte progenitor (NMP) phenotype.
Mon May 11 00:00:00 EDT 2020
RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.
Cell stem cell
Shen C,Sheng Y,Zhu AC,Robinson S,Jiang X,Dong L,Chen H,Su R,Yin Z,Li W,Deng X,Chen Y,Hu YC,Weng H,Huang H,Prince E,Cogle CR,Sun M,Zhang B,Chen CW,Marcucci G,He C,Qian Z,Chen J
12-0453-82 was used in Flow Cytometry to reveal crucial functions of ALKBH5 in leukemogenesis and LSC/LIC self-renewal/maintenance and highlight the therapeutic potential of targeting the ALKBH5/m6A axis.
Thu Jul 02 00:00:00 EDT 2020
Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.
The Journal of experimental medicine
Kang YA,Pietras EM,Passegué E
12-0453 was used in Flow cytometry/Cell sorting to uncover a mechanism that controls myeloid regeneration and early lineage decisions in HSCs and could be targeted in LSCs to normalize leukemic myeloid cell production.
Mon Mar 02 00:00:00 EST 2020
Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.
The Journal of experimental medicine
Kang YA,Pietras EM,Passegué E
12-0453 was used in Flow cytometry/Cell sorting to uncover a mechanism that controls myeloid regeneration and early lineage decisions in HSCs and could be targeted in LSCs to normalize leukemic myeloid cell production.
Mon Mar 02 00:00:00 EST 2020
Contact-dependent delivery of IL-2 by dendritic cells to CD4 T cells in the contraction phase promotes their long-term survival.
Protein & cell
Tong D,Zhang L,Ning F,Xu Y,Hu X,Shi Y
12-0453-82 was used in Flow Cytometry to report here that resting, previously antigen-stimulated CD4 T cells maintain a minimalist response to dendritic cells after their peak activation in vitro.
Sat Feb 01 00:00:00 EST 2020
RIPK3 and Caspase-1/11 Are Necessary for Optimal Antigen-Specific CD8 T Cell Response Elicited by Genetically Modified Listeria monocytogenes.
Frontiers in immunology
Rana A,de Almeida FC,Paico Montero HA,Gonzales Carazas MM,Bortoluci KR,Sad S,Amarante-Mendes GP
Published figure using CD45.1 monoclonal antibody (Product # 12-0453-82) in Flow Cytometry
Fri Mar 26 00:00:00 EDT 2021
Engineering monocyte/macrophage-specific glucocerebrosidase expression in human hematopoietic stem cells using genome editing.
Nature communications
Scharenberg SG,Poletto E,Lucot KL,Colella P,Sheikali A,Montine TJ,Porteus MH,Gomez-Ospina N
Published figure using CD45.1 monoclonal antibody (Product # 12-0453-82) in Flow Cytometry
Fri Jul 03 00:00:00 EDT 2020
Adipocyte-Derived Versican and Macrophage-Derived Biglycan Control Adipose Tissue Inflammation in Obesity.
Cell reports
Han CY,Kang I,Harten IA,Gebe JA,Chan CK,Omer M,Alonge KM,den Hartigh LJ,Gomes Kjerulf D,Goodspeed L,Subramanian S,Wang S,Kim F,Birk DE,Wight TN,Chait A
12-0453-82 was used in Flow Cytometry to provide insights into the role of adipocyte- and macrophage-derived proteoglycans in adipose tissue inflammation in obesity.
Tue Jun 30 00:00:00 EDT 2020
Id1 and Id3 Maintain Steady-State Hematopoiesis by Promoting Sinusoidal Endothelial Cell Survival and Regeneration.
Cell reports
Gadomski S,Singh SK,Singh S,Sarkar T,Klarmann KD,Berenschot M,Seaman S,Jakubison B,Gudmundsson KO,Lockett S,Keller JR
12-0453 was used in Flow cytometry/Cell sorting to investigate the effects of loss of ld genes on adult endothelial cell.
Tue Apr 28 00:00:00 EDT 2020
A Subset of Skin Macrophages Contributes to the Surveillance and Regeneration of Local Nerves.
Immunity
Kolter J,Feuerstein R,Zeis P,Hagemeyer N,Paterson N,d'Errico P,Baasch S,Amann L,Masuda T,Lösslein A,Gharun K,Meyer-Luehmann M,Waskow C,Franzke CW,Grün D,Lämmermann T,Prinz M,Henneke P
12-0453 was used in Flow cytometry/Cell sorting to delineate the postnatal development of dermal macrophages and their differentiation into subsets by adapting single-cell transcriptomics, fate mapping, and imaging.
Tue Jun 18 00:00:00 EDT 2019
Ptpn21 Controls Hematopoietic Stem Cell Homeostasis and Biomechanics.
Cell stem cell
Ni F,Yu WM,Wang X,Fay ME,Young KM,Qiu Y,Lam WA,Sulchek TA,Cheng T,Scadden DT,Qu CK
12-0453 was used in Flow cytometry/Cell sorting to show that Ptpn21 maintains cellular mechanics, which is correlated with its important functions in HSC niche retention and preservation of hematopoietic regeneration capacity.
Thu Apr 04 00:00:00 EDT 2019
TNF-α Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration.
Cell stem cell
Yamashita M,Passegué E
12-0453 was used in Flow cytometry/Cell sorting to reveal several TNF-α-mediated pro-survival mechanisms unique to HSCs, highlight an important role for necroptosis in HSC killing, and establish TNF-α as a major pro-survival and pro-regeneration factor for HSCs.
Thu Sep 05 00:00:00 EDT 2019
Brain Endothelial Cells Maintain Lactate Homeostasis and Control Adult Hippocampal Neurogenesis.
Cell stem cell
Wang J,Cui Y,Yu Z,Wang W,Cheng X,Ji W,Guo S,Zhou Q,Wu N,Chen Y,Chen Y,Song X,Jiang H,Wang Y,Lan Y,Zhou B,Mao L,Li J,Yang H,Guo W,Yang X
12-0453 was used in Flow cytometry/Cell sorting to delineate how the brain endothelium maintains lactate homeostasis and contributes to adult hippocampal neurogenesis and cognitive functions.
Thu Dec 05 00:00:00 EST 2019
Expression of the Phosphatase Ppef2 Controls Survival and Function of CD8+ Dendritic Cells.
Frontiers in immunology
Zwick M,Ulas T,Cho YL,Ried C,Grosse L,Simon C,Bernhard C,Busch DH,Schultze JL,Buchholz VR,Stutte S,Brocker T
12-0453-82 was used in Flow Cytometry to suggest that Ppef2 is crucial to support survival of immature CD8+ DCs, while Ppef2 down-regulation during DC-maturation limits T cell responses.
Tue Oct 27 00:00:00 EDT 2020
Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells.
Cell
Gaya M,Barral P,Burbage M,Aggarwal S,Montaner B,Warren Navia A,Aid M,Tsui C,Maldonado P,Nair U,Ghneim K,Fallon PG,Sekaly RP,Barouch DH,Shalek AK,Bruckbauer A,Strid J,Batista FD
Published figure using CD45.1 monoclonal antibody (Product # 12-0453-82) in Flow Cytometry
Thu Jan 25 00:00:00 EST 2018
IL1RAP potentiates multiple oncogenic signaling pathways in AML.
The Journal of experimental medicine
Mitchell K,Barreyro L,Todorova TI,Taylor SJ,Antony-Debré I,Narayanagari SR,Carvajal LA,Leite J,Piperdi Z,Pendurti G,Mantzaris I,Paietta E,Verma A,Gritsman K,Steidl U
12-0453 was used in Flow cytometry/Cell sorting to show that targeting of interleukin-1 receptor accessory protein via RNA interference, genetic deletion, or antibodies inhibits acute myeloid leukaemia pathogenesis in vitro and in vivo.
Mon Jun 04 00:00:00 EDT 2018
Langerin+ CD8α+ Dendritic Cells Drive Early CD8+ T Cell Activation and IL-12 Production During Systemic Bacterial Infection.
Frontiers in immunology
Prendergast KA,Daniels NJ,Petersen TR,Hermans IF,Kirman JR
12-0453 was used in Flow cytometry/Cell sorting to investigate the impact of depleting langerin+ CD8α+ dendritic cells in a murine model of intravenous infection with Mycobacterium bovis bacille Calmette-Guerin.
Mon Jul 01 00:00:00 EDT 2019
The H3K4 methyltransferase Setd1b is essential for hematopoietic stem and progenitor cell homeostasis in mice.
eLife
Schmidt K,Zhang Q,Tasdogan A,Petzold A,Dahl A,Arneth BM,Slany R,Fehling HJ,Kranz A,Stewart AF,Anastassiadis K
Published figure using CD45.1 monoclonal antibody (Product # 12-0453-82) in Flow Cytometry
Tue Jun 19 00:00:00 EDT 2018
An immune cell spray (ICS) formulation allows for the delivery of functional monocyte/macrophages.
Scientific reports
Beneke V,Küster F,Neehus AL,Hesse C,Lopez-Rodriguez E,Haake K,Rafiei Hashtchin A,Schott JW,Walter D,Braun A,Wolkers WF,Ackermann M,Lachmann N
Published figure using CD45.1 monoclonal antibody (Product # 12-0453-82) in Flow Cytometry
Fri Nov 02 00:00:00 EDT 2018
IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells.
Nature communications
Hsieh WC,Hsu TS,Chang YJ,Lai MZ
12-0453 was used in Flow cytometry/Cell sorting to demonstrate that immunosuppressive defects in XIAP-deficient regulatory T cells can be corrected by treatment with autologous induced Treg cells and IL-6 Receptor blockade.
Wed Jan 31 00:00:00 EST 2018
IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells.
Nature communications
Hsieh WC,Hsu TS,Chang YJ,Lai MZ
12-0453 was used in Flow cytometry/Cell sorting to demonstrate that immunosuppressive defects in XIAP-deficient regulatory T cells can be corrected by treatment with autologous induced Treg cells and IL-6 Receptor blockade.
Wed Jan 31 00:00:00 EST 2018
Lipocalin-2 Functions as Inhibitor of Innate Resistance to Mycobacterium tuberculosis.
Frontiers in immunology
Dahl SL,Woodworth JS,Lerche CJ,Cramer EP,Nielsen PR,Moser C,Thomsen AR,Borregaard N,Cowland JB
12-0453-82 was used in Flow Cytometry to show that lipocalin-2 confers a growth advantage on Mycobacterium tuberculosis in the early stages of infection.
Wed Oct 02 00:00:00 EDT 2019
Bone marrow-derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney disease.
Nature medicine
Hahm E,Wei C,Fernandez I,Li J,Tardi NJ,Tracy M,Wadhwani S,Cao Y,Peev V,Zloza A,Lusciks J,Hayek SS,O'Connor C,Bitzer M,Gupta V,Sever S,Sykes DB,Scadden DT,Reiser J
12-0453 was used in Flow cytometry/Cell sorting to demonstrate a direct pathogenic role of suPAR as a circulating mediator of kidney disease, such as focal segmental glomerulosclerosis.
Sun Jan 01 00:00:00 EST 2017
Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis.
Nature
Hérault A,Binnewies M,Leong S,Calero-Nieto FJ,Zhang SY,Kang YA,Wang X,Pietras EM,Chu SH,Barry-Holson K,Armstrong S,Göttgens B,Passegué E
12-0453 was used in Flow cytometry/Cell sorting to show that in leukaemia, GMP clusters are constantly produced due to lack of termination cytokines that restore haematopoietic stem-cell quiescence.
Thu Apr 06 00:00:00 EDT 2017
Autophagy maintains the metabolism and function of young and old stem cells.
Nature
Ho TT,Warr MR,Adelman ER,Lansinger OM,Flach J,Verovskaya EV,Figueroa ME,Passegué E
12-0453 was used in Flow cytometry/Cell sorting to demonstrate an essential function for autophagy in removing activated mitochondria and controlling oxidative metabolism, thereby maintaining HSC stemness and regenerative potential.
Thu Mar 09 00:00:00 EST 2017
Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells.
Immunity
Essig K,Hu D,Guimaraes JC,Alterauge D,Edelmann S,Raj T,Kranich J,Behrens G,Heiseke A,Floess S,Klein J,Maiser A,Marschall S,Hrabĕ de Angelis M,Leonhardt H,Calkhoven CF,Noessner E,Brocker T,Huehn J,Krug AB,Zavolan M,Baumjohann D,Heissmeyer V
12-0453-82 was used in Miscellaneous, Western Blot to show Roquin-mediated control of PI3K-mTOR signaling prevents autoimmunity by restraining activation and differentiation of conventional T cells and specialization of Treg cells.
Tue Dec 19 00:00:00 EST 2017
Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells.
Immunity
Essig K,Hu D,Guimaraes JC,Alterauge D,Edelmann S,Raj T,Kranich J,Behrens G,Heiseke A,Floess S,Klein J,Maiser A,Marschall S,Hrabĕ de Angelis M,Leonhardt H,Calkhoven CF,Noessner E,Brocker T,Huehn J,Krug AB,Zavolan M,Baumjohann D,Heissmeyer V
12-0453-82 was used in Miscellaneous, Western Blot to show Roquin-mediated control of PI3K-mTOR signaling prevents autoimmunity by restraining activation and differentiation of conventional T cells and specialization of Treg cells.
Tue Dec 19 00:00:00 EST 2017
Adipocyte Accumulation in the Bone Marrow during Obesity and Aging Impairs Stem Cell-Based Hematopoietic and Bone Regeneration.
Cell stem cell
Ambrosi TH,Scialdone A,Graja A,Gohlke S,Jank AM,Bocian C,Woelk L,Fan H,Logan DW,Schürmann A,Saraiva LR,Schulz TJ
12-0453 was used in Flow cytometry/Cell sorting to specify the cellular identities of the adipogenic and osteogenic lineages of the bone.
Thu Jun 01 00:00:00 EDT 2017
Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.
The Journal of experimental medicine
Miao T,Symonds ALJ,Singh R,Symonds JD,Ogbe A,Omodho B,Zhu B,Li S,Wang P
Published figure using CD45.1 monoclonal antibody (Product # 12-0453-82) in Flow Cytometry
Mon Jun 05 00:00:00 EDT 2017
Chemokine Receptor-Dependent Control of Skin Tissue-Resident Memory T Cell Formation.
Journal of immunology (Baltimore, Md. : 1950)
Zaid A,Hor JL,Christo SN,Groom JR,Heath WR,Mackay LK,Mueller SN
12-0453 was used in Flow cytometry/Cell sorting to examine the signals required for the migration of tissue-resident memory T cells within the constrained epidermal environment.
Sun Oct 01 00:00:00 EDT 2017
lncRNA requirements for mouse acute myeloid leukemia and normal differentiation.
eLife
Delás MJ,Sabin LR,Dolzhenko E,Knott SR,Munera Maravilla E,Jackson BT,Wild SA,Kovacevic T,Stork EM,Zhou M,Erard N,Lee E,Kelley DR,Roth M,Barbosa IA,Zuber J,Rinn JL,Smith AD,Hannon GJ
12-0453 was used in Flow cytometry/Cell sorting to assess lncRNA function via an in vivo RNAi screen in a model of acute myeloid leukemia.
Wed Sep 06 00:00:00 EDT 2017
Small molecule p300/catenin antagonist enhances hematopoietic recovery after radiation.
PloS one
Zhao Y,Wu K,Nguyen C,Smbatyan G,Melendez E,Higuchi Y,Chen Y,Kahn M
12-0453 was used in Flow cytometry/Cell sorting to report that the small molecule YH250 stimulates hematopoiesis in lethally or sublethally irradiated mice.
Tue Sep 26 00:00:00 EDT 2017
The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity.
Cell
Damgaard RB,Walker JA,Marco-Casanova P,Morgan NV,Titheradge HL,Elliott PR,McHale D,Maher ER,McKenzie ANJ,Komander D
Published figure using CD45.1 monoclonal antibody (Product # 12-0453-82) in Flow Cytometry
Thu Aug 25 00:00:00 EDT 2016
DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas.
Cell
Herrtwich L,Nanda I,Evangelou K,Nikolova T,Horn V,Erny D,Stefanowski J,Rogell L,Klein C,Gharun K,Follo M,Seidl M,Kremer B,Münke N,Senges J,Fliegauf M,Aschman T,Pfeifer D,Sarrazin S,Sieweke MH,Wagner D,Dierks C,Haaf T,Ness T,Zaiss MM,Voll RE,Deshmukh SD,Prinz M,Goldmann T,Hölscher C,Hauser AE,Lopez-Contreras AJ,Grün D,Gorgoulis V,Diefenbach A,Henneke P,Triantafyllopoulou A
Thu Nov 17 00:00:00 EST 2016
Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal.
Nature cell biology
Pietras EM,Mirantes-Barbeito C,Fong S,Loeffler D,Kovtonyuk LV,Zhang S,Lakshminarasimhan R,Chin CP,Techner JM,Will B,Nerlov C,Steidl U,Manz MG,Schroeder T,Passegué E
12-0453 was used in Flow cytometry/Cell sorting to identify a critical regulatory circuit that tailors HSC responses to acute needs, and is likely to underlie deregulated blood homeostasis in chronic inflammation conditions.
Wed Jun 01 00:00:00 EDT 2016
Group A Streptococcus intranasal infection promotes CNS infiltration by streptococcal-specific Th17 cells.
The Journal of clinical investigation
Dileepan T,Smith ED,Knowland D,Hsu M,Platt M,Bittner-Eddy P,Cohen B,Southern P,Latimer E,Harley E,Agalliu D,Cleary PP
12-0453 was used in Flow cytometry/Cell sorting to elucidate the immunopathological contribution of Group A streptococci (GAS)-specific CD4+ T cells in the induced neuropathology following infection with GAS.
Fri Jan 01 00:00:00 EST 2016
Dendritic cell sphingosine-1-phosphate lyase regulates thymic egress.
The Journal of experimental medicine
Zamora-Pineda J,Kumar A,Suh JH,Zhang M,Saba JD
12-0453 was used in Western Blotting to investigate the role of dendritic cell sphingosine-1-phosphate lyase in thymic egress.
Mon Nov 14 00:00:00 EST 2016
CD4 T Helper Cells Instruct Lymphopenia-Induced Memory-Like CD8 T Cells for Control of Acute LCMV Infection.
Frontiers in immunology
Schmitt ME,Sitte S,Voehringer D
12-0453 was used in Flow cytometry/Cell sorting to determine whether memory-like T cells can efficiently respond to foreign antigen and participate in antiviral immunity.
Wed Nov 20 00:00:00 EST 2019
Lung epithelium and myeloid cells cooperate to clear acute pneumococcal infection.
Mucosal immunology
Dudek M,Puttur F,Arnold-Schrauf C,Kühl AA,Holzmann B,Henriques-Normark B,Berod L,Sparwasser T
12-0453 was used in Flow cytometry/Cell sorting to investigate the extent to which MyD88 signaling is required to control S. pneumoniae infection, showing that lung epithelium and myeloid cells cooperate to clear infection.
Thu Sep 01 00:00:00 EDT 2016
Dendritic Cells Are Dispensable for T Cell Priming and Control of Acute Lymphocytic Choriomeningitis Virus Infection.
Journal of immunology (Baltimore, Md. : 1950)
Hilpert C,Sitte S,Matthies A,Voehringer D
12-0453 was used in Flow cytometry/Cell sorting to study the role of dendritic cells as antigen presenting cells and a source of type I interferons in acute lymphocytic choriomeningitis virus infection.
Sat Oct 01 00:00:00 EDT 2016
Repurposing Treprostinil for Enhancing Hematopoietic Progenitor Cell Transplantation.
Molecular pharmacology
Kazemi Z,Bergmayr C,Prchal-Murphy M,Javaheri T,Themanns M,Pham HT,Strohmaier W,Sexl V,Freissmuth M,Zebedin-Brandl E
12-0453 was used in Flow cytometry/Cell sorting to assess whether treprostinil, a prostacyclin analog, could be repurposed to improve hematopoietic stem cell transplantation.
Wed Jun 01 00:00:00 EDT 2016
Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency.
Stem cell reports
Mucci A,Kunkiel J,Suzuki T,Brennig S,Glage S,Kühnel MP,Ackermann M,Happle C,Kuhn A,Schambach A,Trapnell BC,Hansen G,Moritz T,Lachmann N
Published figure using CD45.1 monoclonal antibody (Product # 12-0453-82) in Flow Cytometry
Tue Aug 09 00:00:00 EDT 2016
Mll-AF4 Confers Enhanced Self-Renewal and Lymphoid Potential during a Restricted Window in Development.
Cell reports
Barrett NA,Malouf C,Kapeni C,Bacon WA,Giotopoulos G,Jacobsen SEW,Huntly BJ,Ottersbach K
12-0453 was used in Flow cytometry/Cell sorting to elucidate the contribution of MII-AF4 in B cell acute lymphoblastic leukaemia early development in the mouse embryo.
Tue Jul 26 00:00:00 EDT 2016
Local fibroblast proliferation but not influx is responsible for synovial hyperplasia in a murine model of rheumatoid arthritis.
Biochemical and biophysical research communications
Matsuo Y,Mizoguchi F,Saito T,Kawahata K,Ueha S,Matsushima K,Inagaki Y,Miyasaka N,Kohsaka H
12-0453-82 was used in Flow cytometry/Cell sorting to indicate that local fibroblast proliferation but not cellular influx is responsible for the synovial hyperplasia in CAIA.
Fri Feb 12 00:00:00 EST 2016
PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells.
Nature medicine
Gur-Cohen S,Itkin T,Chakrabarty S,Graf C,Kollet O,Ludin A,Golan K,Kalinkovich A,Ledergor G,Wong E,Niemeyer E,Porat Z,Erez A,Sagi I,Esmon CT,Ruf W,Lapidot T
12-0453 was used in Flow cytometry/Cell sorting to study long-term repopulating hematopoietic stem cells, showing that PAR1 signaling regulates the retention and recruitment of EPCR-expressing hematopoietic stem cells.
Sun Nov 01 00:00:00 EDT 2015
MHC-mismatched mixed chimerism augments thymic regulatory T-cell production and prevents relapse of EAE in mice.
Proceedings of the National Academy of Sciences of the United States of America
Wu L,Li N,Zhang M,Xue SL,Cassady K,Lin Q,Riggs AD,Zeng D
Published figure using CD45.1 monoclonal antibody (Product # 12-0453-82) in Flow Cytometry
Tue Dec 29 00:00:00 EST 2015
Alternatively activated macrophages promote pancreatic fibrosis in chronic pancreatitis.
Nature communications
Xue J,Sharma V,Hsieh MH,Chawla A,Murali R,Pandol SJ,Habtezion A
Published figure using CD45.1 monoclonal antibody (Product # 12-0453-82) in Flow Cytometry
Mon May 18 00:00:00 EDT 2015
Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality.
Nature communications
Alvarez S,Díaz M,Flach J,Rodriguez-Acebes S,López-Contreras AJ,Martínez D,Cañamero M,Fernández-Capetillo O,Isern J,Passegué E,Méndez J
12-0453 was used in Flow cytometry/Cell sorting to determine that haematopoietic progenitors are particularly sensitive to replication stress.
Mon Oct 12 00:00:00 EDT 2015
Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion.
Nature medicine
Bruns I,Lucas D,Pinho S,Ahmed J,Lambert MP,Kunisaki Y,Scheiermann C,Schiff L,Poncz M,Bergman A,Frenette PS
12-0453 was used in Flow cytometry/Cell sorting to indicate that a terminally differentiated cell type derived from HSCs contributes to the HSC niche, directly regulating HSC behavior.
Sat Nov 01 00:00:00 EDT 2014
Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells.
Nature
Flach J,Bakker ST,Mohrin M,Conroy PC,Pietras EM,Reynaud D,Alvarez S,Diolaiti ME,Ugarte F,Forsberg EC,Le Beau MM,Stohr BA,Méndez J,Morrison CG,Passegué E
12-0453 was used in Flow cytometry/Cell sorting to study functional decline in ageing haematopoietic stem cells due to replicative stress.
Thu Aug 14 00:00:00 EDT 2014
Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages.
Cell
Haldar M,Kohyama M,So AY,Kc W,Wu X,Briseño CG,Satpathy AT,Kretzer NM,Arase H,Rajasekaran NS,Wang L,Egawa T,Igarashi K,Baltimore D,Murphy TL,Murphy KM
Published figure using CD45.1 monoclonal antibody (Product # 12-0453-82) in Flow Cytometry
Thu Mar 13 00:00:00 EDT 2014
Therapeutic antagonists of microRNAs deplete leukemia-initiating cell activity.
The Journal of clinical investigation
Velu CS,Chaubey A,Phelan JD,Horman SR,Wunderlich M,Guzman ML,Jegga AG,Zeleznik-Le NJ,Chen J,Mulloy JC,Cancelas JA,Jordan CT,Aronow BJ,Marcucci G,Bhat B,Gebelein B,Grimes HL
12-0453 was used in Flow cytometry/Cell sorting to identify the genes encoding miR-21 and miR-196b as transcriptional targets of HOX-based leukaemia oncoproteins.
Wed Jan 01 00:00:00 EST 2014
WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner.
The Journal of experimental medicine
Xia P,Wang S,Huang G,Zhu P,Li M,Ye B,Du Y,Fan Z
Published figure using CD45.1 monoclonal antibody (Product # 12-0453-82) in Flow Cytometry
Mon Sep 22 00:00:00 EDT 2014
Perforin competent CD8 T cells are sufficient to cause immune-mediated blood-brain barrier disruption.
PloS one
Johnson HL,Willenbring RC,Jin F,Manhart WA,LaFrance SJ,Pirko I,Johnson AJ
12-0453 was used in Immunofluorescence to study how CD8 T cells are sufficient as a sole perforin-expressing cell type to cause BBB disruption in the PIFS model.
Thu Dec 17 00:00:00 EST 2015
Usp16 contributes to somatic stem-cell defects in Down's syndrome.
Nature
Adorno M,Sikandar S,Mitra SS,Kuo A,Nicolis Di Robilant B,Haro-Acosta V,Ouadah Y,Quarta M,Rodriguez J,Qian D,Reddy VM,Cheshier S,Garner CC,Clarke MF
12-0453 was used in Flow cytometry/Cell sorting to demonstrate a role for USP16 in antagonising the self-renewal and senescence pathways in Down's syndrome.
Thu Sep 19 00:00:00 EDT 2013
FOXO3A directs a protective autophagy program in haematopoietic stem cells.
Nature
Warr MR,Binnewies M,Flach J,Reynaud D,Garg T,Malhotra R,Debnath J,Passegué E
12-0453 was used in Flow cytometry/Cell sorting to show how FOXO3A directs a protective autophagy program in haematopoietic stem cells.
Thu Feb 21 00:00:00 EST 2013
Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4⁺ T cell immunity.
Nature immunology
Reis BS,Rogoz A,Costa-Pinto FA,Taniuchi I,Mucida D
Published figure using CD45.1 monoclonal antibody (Product # 12-0453-82) in Flow Cytometry
Fri Mar 01 00:00:00 EST 2013
Expression and regulation of intergenic long noncoding RNAs during T cell development and differentiation.
Nature immunology
Hu G,Tang Q,Sharma S,Yu F,Escobar TM,Muljo SA,Zhu J,Zhao K
12-0453 was used in Flow cytometry/Cell sorting to identify essential components of a regulatory circuit important for the migration of TH2 cells.
Fri Nov 01 00:00:00 EDT 2013
Absence of signaling into CD4⁺ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3⁺ regulatory T cells.
Nature immunology
Strainic MG,Shevach EM,An F,Lin F,Medof ME
12-0453 was used in Flow cytometry/Cell sorting to demonstrate that a lack of signalling can convert CD4(+) cells to Foxp3(+) iT(reg) cells, amongst other effects.
Fri Feb 01 00:00:00 EST 2013
Early immunisation with dendritic cells after allogeneic bone marrow transplantation elicits graft vs tumour reactivity.
British journal of cancer
Gigi V,Stein J,Askenasy N,Yaniv I,Ash S
12-0453 was used in Flow cytometry/Cell sorting to assess the impact of dendritic cell immunisation on graft vs tumour reactions triggered by allogeneic bone marrow transplantation.
Tue Mar 19 00:00:00 EDT 2013
Arrayed lentiviral barcoding for quantification analysis of hematopoietic dynamics.
Stem cells (Dayton, Ohio)
Grosselin J,Sii-Felice K,Payen E,Chretien S,Tronik-Le Roux D,Leboulch P
Published figure using CD45.1 monoclonal antibody (Product # 12-0453-82) in Flow Cytometry
Tue Oct 01 00:00:00 EDT 2013
Cutting edge: Macrophages are required for localization of antigen-activated B cells to the follicular perimeter and the subsequent germinal center response.
Journal of immunology (Baltimore, Md. : 1950)
Nikbakht N,Shen S,Manser T
12-0453 was used in Immunocytochemistry to examine whether the migration and rapid proliferation of antigen-specific B cells at the T cell zone boundaries in the spleen occurs without splenic macrophages present.
Wed May 15 00:00:00 EDT 2013
G-CSF/anti-G-CSF antibody complexes drive the potent recovery and expansion of CD11b+Gr-1+ myeloid cells without compromising CD8+ T cell immune responses.
Journal of hematology & oncology
Rubinstein MP,Salem ML,Doedens AL,Moore CJ,Chiuzan C,Rivell GL,Cole DJ,Goldrath AW
12-0453 was used in Flow cytometry/Cell sorting to evaluate whether the biological activity of G-CSF can be improved by pre-association with anti-G-CSF monoclonal antibodies prior to injection.
Tue Oct 01 00:00:00 EDT 2013
Type I interferons maintain Foxp3 expression and T-regulatory cell functions under inflammatory conditions in mice.
Gastroenterology
Lee SE,Li X,Kim JC,Lee J,González-Navajas JM,Hong SH,Park IK,Rhee JH,Raz E
12-0453 was used in Flow cytometry/Cell sorting to study the role of type I interferons during intestinal homeostasis regulation in a T cell-induced colitis mouse model.
Sun Jul 01 00:00:00 EDT 2012
Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AML.
Blood
Li Z,Huang H,Li Y,Jiang X,Chen P,Arnovitz S,Radmacher MD,Maharry K,Elkahloun A,Yang X,He C,He M,Zhang Z,Dohner K,Neilly MB,Price C,Lussier YA,Zhang Y,Larson RA,Le Beau MM,Caligiuri MA,Bullinger L,Valk PJ,Delwel R,Lowenberg B,Liu PP,Marcucci G,Bloomfield CD,Rowley JD,Chen J
12-0453 was used in Flow cytometry/Cell sorting to study the prognostic impact of the four members of the miR-181 family in patients with CA-AML.
Thu Mar 08 00:00:00 EST 2012
Overexpression of Snai3 suppresses lymphoid- and enhances myeloid-cell differentiation.
European journal of immunology
Dahlem T,Cho S,Spangrude GJ,Weis JJ,Weis JH
12-0453 was used in Flow cytometry/Cell sorting to investigate the role of the transcriptional repressor Snai3 protein in the derivation of cells of the haematopoietic system.
Sun Apr 01 00:00:00 EDT 2012
Arthritogenic self-reactive CD4+ T cells acquire an FR4hiCD73hi anergic state in the presence of Foxp3+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Martinez RJ,Zhang N,Thomas SR,Nandiwada SL,Jenkins MK,Binstadt BA,Mueller DL
12-0453 was used in Flow cytometry/Cell sorting to suggest that autoimmune arthritis develops in the setting of lymphopenia when Foxp3(+)CD4(+) regulatory T cells are insufficient to functionally inactivate all autoreactive CD4(+) T cells that encounter self-Ag.
Sun Jan 01 00:00:00 EST 2012
In vitro Ag Cross-presentation and in vivo Ag Cross-presentation by Dendritic Cells in the Mouse.
Bio-protocol
Ghosh M,Shapiro LH
Published figure using CD45.1 monoclonal antibody (Product # 12-0453-82) in Flow Cytometry
Thu Dec 20 00:00:00 EST 2012
IFN-gamma signaling in the central nervous system controls the course of experimental autoimmune encephalomyelitis independently of the localization and composition of inflammatory foci.
Journal of neuroinflammation
Lee E,Chanamara S,Pleasure D,Soulika AM
12-0453 was used in Immunohistochemistry to provide strong evidence that links microglial STAT1 inactivation to vestibular dysfunction.
Mon Jan 16 00:00:00 EST 2012
Administration of alpha-galactosylceramide impairs the survival of dendritic cell subpopulations in vivo.
Journal of leukocyte biology
Simkins HM,Hyde E,Farrand KJ,Ong ML,Degli-Esposti MA,Hermans IF,Ronchese F
12-0453 was used in Flow cytometry/Cell sorting to examine whether recognition of α-GalCer presented on CD1d-expressing DCs and B cells in vivo elicits the cytotoxic activity of iNKT cells.
Sun May 01 00:00:00 EDT 2011
Hydrodynamic delivery of human IL-15 cDNA increases murine natural killer cell recovery after syngeneic bone marrow transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
Barao I,Alvarez M,Redelman D,Weiss JM,Ortaldo JR,Wiltrout RH,Murphy WJ
12-0453 was used in Flow cytometry/Cell sorting to highlight cytokine gene transfer-based methods as a potential platform for natural killer cell recovery after bone marrow transplantation in mice.
Thu Dec 01 00:00:00 EST 2011
Helios is associated with CD4 T cells differentiating to T helper 2 and follicular helper T cells in vivo independently of Foxp3 expression.
PloS one
Serre K,Bénézech C,Desanti G,Bobat S,Toellner KM,Bird R,Chan S,Kastner P,Cunningham AF,Maclennan IC,Mohr E
12-0453 was used in Flow cytometry/Cell sorting to reveal the selective upregulation of Helios during Th2 and TFh responses to alum-protein vaccines.
Mon Oct 17 00:00:00 EDT 2011
One naive T cell, multiple fates in CD8+ T cell differentiation.
The Journal of experimental medicine
Gerlach C,van Heijst JW,Swart E,Sie D,Armstrong N,Kerkhoven RM,Zehn D,Bevan MJ,Schepers K,Schumacher TN
12-0453 was used in Flow cytometry/Cell sorting to assess the potential for development of single naive T cells into different subsets.
Mon Jun 07 00:00:00 EDT 2010
Direct presentation regulates the magnitude of the CD8+ T cell response to cell-associated antigen through prolonged T cell proliferation.
Journal of immunology (Baltimore, Md. : 1950)
Tatum AM,Watson AM,Schell TD
12-0453 was used in Flow cytometry/Cell sorting to reveal that direct presentation by nonprofessional APCs can dramatically enhance accumulation of CD8(+) T cells during primary response.
Wed Sep 01 00:00:00 EDT 2010
The NOD/RIP2 pathway is essential for host defenses against Chlamydophila pneumoniae lung infection.
PLoS pathogens
Shimada K,Chen S,Dempsey PW,Sorrentino R,Alsabeh R,Slepenkin AV,Peterson E,Doherty TM,Underhill D,Crother TR,Arditi M
12-0453 was used in Flow cytometry/Cell sorting to investigate the role of the Nod/Rip2 pathway in responses to Chlamydophila pneumoniae infection, showing that it is essential for host defences against pneumonia.
Wed Apr 01 00:00:00 EDT 2009
Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation.
Journal of immunology (Baltimore, Md. : 1950)
Lal G,Zhang N,van der Touw W,Ding Y,Ju W,Bottinger EP,Reid SP,Levy DE,Bromberg JS
12-0453 was used in Flow cytometry/Cell sorting to investigate Foxp3 as the master switch for Tregs, showing that expression is regulated by DNA methylation in Tregs.
Thu Jan 01 00:00:00 EST 2009
IL-7 and IL-15 differentially regulate CD8+ T-cell subsets during contraction of the immune response.
Blood
Rubinstein MP,Lind NA,Purton JF,Filippou P,Best JA,McGhee PA,Surh CD,Goldrath AW
12-0453 was used in Flow cytometry/Cell sorting to study IL-7 and IL-15 regulation of CD8+ T-cell subsets during contraction of the immune response.
Sat Nov 01 00:00:00 EDT 2008
Rapid accumulation of adoptively transferred CD8+ T cells at the tumor site is associated with long-term control of SV40 T antigen-induced tumors.
Cancer immunology, immunotherapy : CII
Yorty JL,Tevethia SS,Schell TD
12-0453 was used in Flow cytometry/Cell sorting to show that greater control of established autochthonous tumours is associated with the early accumulation of adoptively transferred T cells.
Sun Jun 01 00:00:00 EDT 2008
An intense form of homeostatic proliferation of naive CD8+ cells driven by IL-2.
The Journal of experimental medicine
Cho JH,Boyman O,Kim HO,Hahm B,Rubinstein MP,Ramsey C,Kim DM,Surh CD,Sprent J
12-0453 was used in Flow cytometry/Cell sorting to describe a novel form of homeostatic proliferation that occurs when naive T cells encounter raised levels of IL-2 and IL-15 in vivo.
Mon Aug 06 00:00:00 EDT 2007
Obesity is associated with macrophage accumulation in adipose tissue.
The Journal of clinical investigation
Weisberg SP,McCann D,Desai M,Rosenbaum M,Leibel RL,Ferrante AW
12-0453 was used in Flow cytometry/Cell sorting to demonstrate adipose tissue macrophages participate in inflammatory pathways that are activated in obese individuals..
Mon Dec 01 00:00:00 EST 2003
