Product References
Tet-mediated DNA demethylation regulates specification of hematopoietic stem and progenitor cells during mammalian embryogenesis.
Science advances
Ma L,Tang Q,Gao X,Lee J,Lei R,Suzuki M,Zheng D,Ito K,Frenette PS,Dawlaty MM
Published figure using CD45.1 monoclonal antibody (Product # 14-0453-82) in Flow Cytometry
Fri Mar 04 00:00:00 EST 2022
Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation.
Nature immunology
Rivas MA,Meydan C,Chin CR,Challman MF,Kim D,Bhinder B,Kloetgen A,Viny AD,Teater MR,McNally DR,Doane AS,Béguelin W,Fernández MTC,Shen H,Wang X,Levine RL,Chen Z,Tsirigos A,Elemento O,Mason CE,Melnick AM
Published figure using CD45.1 monoclonal antibody (Product # 14-0453-82) in Flow Cytometry
Mon Feb 01 00:00:00 EST 2021
Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions.
The Journal of experimental medicine
Ho TT,Dellorusso PV,Verovskaya EV,Bakker ST,Flach J,Smith LK,Ventura PB,Lansinger OM,Hérault A,Zhang SY,Kang YA,Mitchell CA,Villeda SA,Passegué E
Published figure using CD45.1 monoclonal antibody (Product # 14-0453-82) in Flow Cytometry
Mon Jul 05 00:00:00 EDT 2021
Differentiation of fetal hematopoietic stem cells requires ARID4B to restrict autocrine KITLG/KIT-Src signaling.
Cell reports
Young IC,Wu B,Andricovich J,Chuang ST,Li R,Tzatsos A,Wu RC,Wu MY
Published figure using CD45.1 monoclonal antibody (Product # 14-0453-82) in Flow Cytometry
Tue Nov 23 00:00:00 EST 2021
Development of a VRC01-class germline targeting immunogen derived from anti-idiotypic antibodies.
Cell reports
Seydoux E,Wan YH,Feng J,Wall A,Aljedani S,Homad LJ,MacCamy AJ,Weidle C,Gray MD,Brumage L,Taylor JJ,Pancera M,Stamatatos L,McGuire AT
Published figure using CD45.1 monoclonal antibody (Product # 14-0453-82) in Flow Cytometry
Tue May 04 00:00:00 EDT 2021
Ddb1 Is Essential for the Expansion of CD4+ Helper T Cells by Regulating Cell Cycle Progression and Cell Death.
Frontiers in immunology
Yang L,Chen W,Li L,Xiao Y,Fan S,Zhang Q,Xia T,Li M,Hong Y,Zhao T,Li Q,Liu WH,Xiao N
Published figure using CD45.1 monoclonal antibody (Product # 14-0453-82) in Flow Cytometry
Mon Dec 20 00:00:00 EST 2021
Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.
The Journal of experimental medicine
Kang YA,Pietras EM,Passegué E
Published figure using CD45.1 monoclonal antibody (Product # 14-0453-82) in Flow Cytometry
Mon Mar 02 00:00:00 EST 2020
RIPK3 and Caspase-1/11 Are Necessary for Optimal Antigen-Specific CD8 T Cell Response Elicited by Genetically Modified Listeria monocytogenes.
Frontiers in immunology
Rana A,de Almeida FC,Paico Montero HA,Gonzales Carazas MM,Bortoluci KR,Sad S,Amarante-Mendes GP
Published figure using CD45.1 monoclonal antibody (Product # 14-0453-82) in Flow Cytometry
Fri Mar 26 00:00:00 EDT 2021
Engineering monocyte/macrophage-specific glucocerebrosidase expression in human hematopoietic stem cells using genome editing.
Nature communications
Scharenberg SG,Poletto E,Lucot KL,Colella P,Sheikali A,Montine TJ,Porteus MH,Gomez-Ospina N
Published figure using CD45.1 monoclonal antibody (Product # 14-0453-82) in Flow Cytometry
Fri Jul 03 00:00:00 EDT 2020
Commensal Microbiota Promote Lung Cancer Development via γδ T Cells.
Cell
Jin C,Lagoudas GK,Zhao C,Bullman S,Bhutkar A,Hu B,Ameh S,Sandel D,Liang XS,Mazzilli S,Whary MT,Meyerson M,Germain R,Blainey PC,Fox JG,Jacks T
14-0453-82 was used in Flow Cytometry to link local microbiota-immune crosstalk to lung tumor development and thereby define key cellular and molecular mediators that may serve as effective targets in lung cancer intervention.
Thu Feb 21 00:00:00 EST 2019
Bone marrow dendritic cells regulate hematopoietic stem/progenitor cell trafficking.
The Journal of clinical investigation
Zhang J,Supakorndej T,Krambs JR,Rao M,Abou-Ezzi G,Ye RY,Li S,Trinkaus K,Link DC
14-0453 was used in Flow cytometry/Cell sorting to show that HSPC mobilization after cDC ablation is attenuated in mice lacking CXCR2 expression.
Tue Apr 30 00:00:00 EDT 2019
Inducible IL-7 Hyperexpression Influences Lymphocyte Homeostasis and Function and Increases Allograft Rejection.
Frontiers in immunology
Schreiber M,Weigelt M,Karasinsky A,Anastassiadis K,Schallenberg S,Petzold C,Bonifacio E,Kretschmer K,Hommel A
14-0453 was used in Flow cytometry/Cell sorting to show that transient hyperexpression of IL-7 can impair immune regulation, through disturbances in lymphocyte development pathways, and decrease graft survival time, even under immunosuppression.
Mon Sep 14 00:00:00 EDT 2020
Critical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells.
Oncoimmunology
Salerno F,Guislain A,Freen-Van Heeren JJ,Nicolet BP,Young HA,Wolkers MC
14-0453 was used in Flow cytometry/Cell sorting to conclude that post-transcriptional mechanisms could be modulated to potentiate effective T cell therapies in cancer.
Tue Jan 12 00:00:00 EST 2021
Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis.
Nature communications
Lee HG,Lee JU,Kim DH,Lim S,Kang I,Choi JM
14-0453 was used in Flow cytometry/Cell sorting to reveal the innate-like pathogenic function of antigen non-related memory CD4+ T cells, which contribute to the development of autoimmune diseases.
Tue Feb 12 00:00:00 EST 2019
Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells.
Cell
Gaya M,Barral P,Burbage M,Aggarwal S,Montaner B,Warren Navia A,Aid M,Tsui C,Maldonado P,Nair U,Ghneim K,Fallon PG,Sekaly RP,Barouch DH,Shalek AK,Bruckbauer A,Strid J,Batista FD
Published figure using CD45.1 monoclonal antibody (Product # 14-0453-82) in Flow Cytometry
Thu Jan 25 00:00:00 EST 2018
Irg1 expression in myeloid cells prevents immunopathology during M. tuberculosis infection.
The Journal of experimental medicine
Nair S,Huynh JP,Lampropoulou V,Loginicheva E,Esaulova E,Gounder AP,Boon ACM,Schwarzkopf EA,Bradstreet TR,Edelson BT,Artyomov MN,Stallings CL,Diamond MS
14-0453 was used in Flow cytometry/Cell sorting to study the role of Immune responsive gene 1 in the modulation of inflammation during Mycobacterium tuberculosis infection.
Mon Apr 02 00:00:00 EDT 2018
The H3K4 methyltransferase Setd1b is essential for hematopoietic stem and progenitor cell homeostasis in mice.
eLife
Schmidt K,Zhang Q,Tasdogan A,Petzold A,Dahl A,Arneth BM,Slany R,Fehling HJ,Kranz A,Stewart AF,Anastassiadis K
Published figure using CD45.1 monoclonal antibody (Product # 14-0453-82) in Flow Cytometry
Tue Jun 19 00:00:00 EDT 2018
An immune cell spray (ICS) formulation allows for the delivery of functional monocyte/macrophages.
Scientific reports
Beneke V,Küster F,Neehus AL,Hesse C,Lopez-Rodriguez E,Haake K,Rafiei Hashtchin A,Schott JW,Walter D,Braun A,Wolkers WF,Ackermann M,Lachmann N
Published figure using CD45.1 monoclonal antibody (Product # 14-0453-82) in Flow Cytometry
Fri Nov 02 00:00:00 EDT 2018
Fludarabine as a cost-effective adjuvant to enhance engraftment of human normal and malignant hematopoiesis in immunodeficient mice.
Scientific reports
Pievani A,Michelozzi IM,Rambaldi B,Granata V,Corsi A,Dazzi F,Biondi A,Serafini M
14-0453 was used in Flow cytometry/Cell sorting to present a novel and affordable model for engraftment of human normal and malignant hematopoiesis in immunodeficient mice.
Thu Jun 14 00:00:00 EDT 2018
LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells.
Genome biology
Grigoryan A,Guidi N,Senger K,Liehr T,Soller K,Marka G,Vollmer A,Markaki Y,Leonhardt H,Buske C,Lipka DB,Plass C,Zheng Y,Mulaw MA,Geiger H,Florian MC
14-0453 was used in Flow cytometry/Cell sorting to show that not all histone modifications display a polar localization and that a reduction in H4K16ac amount and loss of epipolarity are specific to aged HSCs.
Wed Nov 07 00:00:00 EST 2018
Regulation of the effector function of CD8+ T cells by gut microbiota-derived metabolite butyrate.
Scientific reports
Luu M,Weigand K,Wedi F,Breidenbend C,Leister H,Pautz S,Adhikary T,Visekruna A
14-0453 was used in Flow cytometry/Cell sorting to might have significant implications in adoptive immunotherapy of cancers and in anti-viral immunity.
Wed Sep 26 00:00:00 EDT 2018
Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.
The Journal of experimental medicine
Miao T,Symonds ALJ,Singh R,Symonds JD,Ogbe A,Omodho B,Zhu B,Li S,Wang P
Published figure using CD45.1 monoclonal antibody (Product # 14-0453-82) in Flow Cytometry
Mon Jun 05 00:00:00 EDT 2017
Mast cells acquire MHCII from dendritic cells during skin inflammation.
The Journal of experimental medicine
Dudeck J,Medyukhina A,Fröbel J,Svensson CM,Kotrba J,Gerlach M,Gradtke AC,Schröder B,Speier S,Figge MT,Dudeck A
14-0453 was used in Flow cytometry/Cell sorting to identify an innate intercellular communication arming resident mast cells with key dendritic cell(DC) functions that might contribute to the acute defence potential during critical periods of migration-based DC absence.
Mon Dec 04 00:00:00 EST 2017
Dissection of SAP-dependent and SAP-independent SLAM family signaling in NKT cell development and humoral immunity.
The Journal of experimental medicine
Chen S,Cai C,Li Z,Liu G,Wang Y,Blonska M,Li D,Du J,Lin X,Yang M,Dong Z
14-0453-82 was used in Flow Cytometry to examine NKT cell development and humoral immunity in mice completely deficient in SFR.
Wed Feb 01 00:00:00 EST 2017
NFκB-Pim-1-Eomesodermin axis is critical for maintaining CD8 T-cell memory quality.
Proceedings of the National Academy of Sciences of the United States of America
Knudson KM,Pritzl CJ,Saxena V,Altman A,Daniels MA,Teixeiro E
14-0453 was used in Flow cytometry/Cell sorting to show that TCR/antigenic signals regulate the induction of a NFκB/Pim-1 feedback loop that controls expression of Eomes and thereby long-term maintenance of the memory pool.
Tue Feb 28 00:00:00 EST 2017
Deficiency of transcription factor RelB perturbs myeloid and DC development by hematopoietic-extrinsic mechanisms.
Proceedings of the National Academy of Sciences of the United States of America
Briseño CG,Gargaro M,Durai V,Davidson JT,Theisen DJ,Anderson DA,Novack DV,Murphy TL,Murphy KM
14-0453 was used in Flow cytometry/Cell sorting to suggest that there is an unrecognized but critical role for RelB within the nonhematopoietic niche that controls normal myelopoiesis.
Tue Apr 11 00:00:00 EDT 2017
A non-canonical function of Ezh2 preserves immune homeostasis.
EMBO reports
Vasanthakumar A,Xu D,Lun AT,Kueh AJ,van Gisbergen KP,Iannarella N,Li X,Yu L,Wang D,Williams BR,Lee SC,Majewski IJ,Godfrey DI,Smyth GK,Alexander WS,Herold MJ,Kallies A,Nutt SL,Allan RS
14-0453 was used in Flow cytometry/Cell sorting to identify a chromatin-independent function of enhancer of zeste 2 that impacts on the development of the immune system.
Sat Apr 01 00:00:00 EDT 2017
Minimally manipulated murine regulatory T cells purified by reversible Fab Multimers are potent suppressors for adoptive T-cell therapy.
European journal of immunology
Mohr F,Fischer JC,Nikolaus M,Stemberger C,Dreher S,Verschoor A,Haas T,Poeck H,Busch DH
14-0453 was used in Flow cytometry/Cell sorting to demonstrate how reversible Fab multimer-based murine regulatory T cell (Treg) isolation can prevent conventional antibody label-induced interferences, and offer higher potency when applied to Treg-based therapies.
Fri Dec 01 00:00:00 EST 2017
IL-1β and IL-23 Promote Extrathymic Commitment of CD27+CD122- γδ T Cells to γδT17 Cells.
Journal of immunology (Baltimore, Md. : 1950)
Muschaweckh A,Petermann F,Korn T
14-0453 was used in Flow cytometry/Cell sorting to study the mechanisms by which the peripheral pool of γδ T cells retain a considerable degree of plasticity.
Sun Oct 15 00:00:00 EDT 2017
WASH maintains NKp46+ ILC3 cells by promoting AHR expression.
Nature communications
Xia P,Liu J,Wang S,Ye B,Du Y,Xiong Z,Han ZG,Tong L,Fan Z
14-0453 was used in Flow cytometry/Cell sorting to study how WASH-mediated AHR expression has a critical function in the maintenance of NKp46(+) ILC3s.
Wed Jun 07 00:00:00 EDT 2017
The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity.
Cell
Damgaard RB,Walker JA,Marco-Casanova P,Morgan NV,Titheradge HL,Elliott PR,McHale D,Maher ER,McKenzie ANJ,Komander D
Published figure using CD45.1 monoclonal antibody (Product # 14-0453-82) in Flow Cytometry
Thu Aug 25 00:00:00 EDT 2016
A septin requirement differentiates autonomous and contact-facilitated T cell proliferation.
Nature immunology
Mujal AM,Gilden JK,Gérard A,Kinoshita M,Krummel MF
14-0453 was used in Flow cytometry/Cell sorting to characterise T cells lacking the septin cytoskeleton.
Tue Mar 01 00:00:00 EST 2016
B-cell survival and development controlled by the coordination of NF-κB family members RelB and cRel.
Blood
Almaden JV,Liu YC,Yang E,Otero DC,Birnbaum H,Davis-Turak J,Asagiri M,David M,Goldrath AW,Hoffmann A
14-0453 was used in Flow cytometry/Cell sorting to demonstrate that BAFF signalling coordinates the canonical and non-canonical NF-κB pathways to ensure robust B-cell development.
Thu Mar 10 00:00:00 EST 2016
T Cell Priming by Activated Nlrc5-Deficient Dendritic Cells Is Unaffected despite Partially Reduced MHC Class I Levels.
Journal of immunology (Baltimore, Md. : 1950)
Rota G,Ludigs K,Siegert S,Tardivel A,Morgado L,Reith W,De Gassart A,Guarda G
14-0453 was used in Flow cytometry/Cell sorting to show that Nlrc5 deficiency is not sufficient to hinder T cell activation, highlighting the robustness of the T cell priming process by activated dendritic cells.
Fri Apr 01 00:00:00 EDT 2016
Differential Responsiveness of Innate-like IL-17- and IFN-γ-Producing γδ T Cells to Homeostatic Cytokines.
Journal of immunology (Baltimore, Md. : 1950)
Corpuz TM,Stolp J,Kim HO,Pinget GV,Gray DH,Cho JH,Sprent J,Webster KE
14-0453 was used in Flow cytometry/Cell sorting to suggest that γδ T cell subsets do not directly compete with each other for cytokines, but instead fall into resource niches with other functionally similar lymphocytes.
Fri Jan 15 00:00:00 EST 2016
IL-10+ Innate-like B Cells Are Part of the Skin Immune System and Require α4β1 Integrin To Migrate between the Peritoneum and Inflamed Skin.
Journal of immunology (Baltimore, Md. : 1950)
Geherin SA,Gómez D,Glabman RA,Ruthel G,Hamann A,Debes GF
14-0453 was used in Flow cytometry/Cell sorting to investigate innate-like B cells within the skin.
Tue Mar 15 00:00:00 EDT 2016
Blood Stem Cell Activity Is Arrested by Th1-Mediated Injury Preventing Engraftment following Nonmyeloablative Conditioning.
Journal of immunology (Baltimore, Md. : 1950)
Müller AM,Florek M,Kohrt HE,Küpper NJ,Filatenkov A,Linderman JA,Hadeiba H,Negrin RS,Shizuru JA
14-0453 was used in Flow cytometry/Cell sorting to shed new light on the effects of CD4+ T cells on HSC biology.
Tue Nov 15 00:00:00 EST 2016
A Novel Allosteric Mechanism of NF-κB Dimerization and DNA Binding Targeted by an Anti-Inflammatory Drug.
Molecular and cellular biology
Ashkenazi S,Plotnikov A,Bahat A,Ben-Zeev E,Warszawski S,Dikstein R
14-0453 was used in Western Blotting to identify a molecular inhibitor of NF-κB p65 protein dimerization by molecular screening, as a potential therapeutic target for several diseases caused by its deregulation.
Fri Apr 01 00:00:00 EDT 2016
Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency.
Stem cell reports
Mucci A,Kunkiel J,Suzuki T,Brennig S,Glage S,Kühnel MP,Ackermann M,Happle C,Kuhn A,Schambach A,Trapnell BC,Hansen G,Moritz T,Lachmann N
Published figure using CD45.1 monoclonal antibody (Product # 14-0453-82) in Flow Cytometry
Tue Aug 09 00:00:00 EDT 2016
The elongation factor Spt5 facilitates transcription initiation for rapid induction of inflammatory-response genes.
Nature communications
Diamant G,Bahat A,Dikstein R
14-0453 was used in Western Blotting to support Spt5s role in maintenance of TFIID-promoter association and escape to support rapid transcriptional induction and re-initiation of inflammatory-response genes.
Mon May 16 00:00:00 EDT 2016
Trogocytosis-associated cell to cell spread of intracellular bacterial pathogens.
eLife
Steele S,Radlinski L,Taft-Benz S,Brunton J,Kawula TH
14-0453 was used in Flow cytometry/Cell sorting to study trogocytosis-associated cell to cell spread of intracellular bacterial pathogens.
Sat Jan 23 00:00:00 EST 2016
Peripheral self-reactivity regulates antigen-specific CD8 T-cell responses and cell division under physiological conditions.
Open biology
Swee LK,Tan ZW,Sanecka A,Yoshida N,Patel H,Grotenbreg G,Frickel EM,Ploegh HL
14-0453 was used in Flow cytometry/Cell sorting to show that potential effector functions and basal proliferation of CD8 T cells are set by self-reactivity thresholds.
Tue Nov 01 00:00:00 EDT 2016
Tumor Progression Locus 2 (Tpl2) Activates the Mammalian Target of Rapamycin (mTOR) Pathway, Inhibits Forkhead Box P3 (FoxP3) Expression, and Limits Regulatory T Cell (Treg) Immunosuppressive Functions.
The Journal of biological chemistry
Li X,Acuff NV,Peeks AR,Kirkland R,Wyatt KD,Nagy T,Watford WT
14-0453-82 was used in Flow Cytometry to demonstrate that the serine/threonine kinase tumour progression locus 2 constrains the development of inducible regulatory T cells.
Fri Aug 05 00:00:00 EDT 2016
Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia.
Nature
Wong TN,Ramsingh G,Young AL,Miller CA,Touma W,Welch JS,Lamprecht TL,Shen D,Hundal J,Fulton RS,Heath S,Baty JD,Klco JM,Ding L,Mardis ER,Westervelt P,DiPersio JF,Walter MJ,Graubert TA,Ley TJ,Druley T,Link DC,Wilson RK
14-0453 was used in Flow cytometry/Cell sorting to investigate how prior exposure to cytotoxic therapy influences leukemogenesis and TP53 mutations in t-AML/t-MDS patients.
Thu Feb 26 00:00:00 EST 2015
Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance.
Cell
Steinert EM,Schenkel JM,Fraser KA,Beura LK,Manlove LS,Igyártó BZ,Southern PJ,Masopust D
14-0453 was used in Immunofluorescence to indicate that most host cells are surveyed for reinfection by segregated residents rather than by recirculating cells that migrate throughout the blood and body.
Thu May 07 00:00:00 EDT 2015
T-box Transcription Factors Combine with the Cytokines TGF-β and IL-15 to Control Tissue-Resident Memory T Cell Fate.
Immunity
Mackay LK,Wynne-Jones E,Freestone D,Pellicci DG,Mielke LA,Newman DM,Braun A,Masson F,Kallies A,Belz GT,Carbone FR
14-0453 was used in Flow cytometry/Cell sorting to indicate that the T-box TFs control the two cytokines, TGF-β and IL-15, which are pivotal for CD8(+)CD103(+) Trm cell development and survival.
Tue Dec 15 00:00:00 EST 2015
Bcl11b is essential for group 2 innate lymphoid cell development.
The Journal of experimental medicine
Walker JA,Oliphant CJ,Englezakis A,Yu Y,Clare S,Rodewald HR,Belz G,Liu P,Fallon PG,McKenzie AN
14-0453 was used in Flow cytometry/Cell sorting to study the role of Bcl11b in the differentiation of group 2 innate lymphoid cells.
Mon Jun 01 00:00:00 EDT 2015
Transcriptional repressor ZEB2 promotes terminal differentiation of CD8+ effector and memory T cell populations during infection.
The Journal of experimental medicine
Omilusik KD,Best JA,Yu B,Goossens S,Weidemann A,Nguyen JV,Seuntjens E,Stryjewska A,Zweier C,Roychoudhuri R,Gattinoni L,Bird LM,Higashi Y,Kondoh H,Huylebroeck D,Haigh J,Goldrath AW
14-0453-82 was used in Flow Cytometry to study the upregulation of ZEB2 by activated T cells, specifically in the KLRG1(hi) effector CD8(+) T cell subset.
Mon Nov 16 00:00:00 EST 2015
MHC-mismatched mixed chimerism augments thymic regulatory T-cell production and prevents relapse of EAE in mice.
Proceedings of the National Academy of Sciences of the United States of America
Wu L,Li N,Zhang M,Xue SL,Cassady K,Lin Q,Riggs AD,Zeng D
Published figure using CD45.1 monoclonal antibody (Product # 14-0453-82) in Flow Cytometry
Tue Dec 29 00:00:00 EST 2015
BCG Skin Infection Triggers IL-1R-MyD88-Dependent Migration of EpCAMlow CD11bhigh Skin Dendritic cells to Draining Lymph Node During CD4+ T-Cell Priming.
PLoS pathogens
Bollampalli VP,Harumi Yamashiro L,Feng X,Bierschenk D,Gao Y,Blom H,Henriques-Normark B,Nylén S,Rothfuchs AG
14-0453 was used in Flow cytometry/Cell sorting to investigate the transport of antigens from the periphery to the draining lymph node during infection with Mycobacterium bovis Bacille Calmette-Guérin.
Thu Oct 01 00:00:00 EDT 2015
Peptide-MHC-I from Endogenous Antigen Outnumber Those from Exogenous Antigen, Irrespective of APC Phenotype or Activation.
PLoS pathogens
Sei JJ,Haskett S,Kaminsky LW,Lin E,Truckenmiller ME,Bellone CJ,Buller RM,Norbury CC
14-0453 was used in Flow cytometry/Cell sorting to suggest that direct antigen presentation is the dominant pathway in mice during mousepox.
Mon Jun 01 00:00:00 EDT 2015
The atypical chemokine receptor ACKR2 suppresses Th17 responses to protein autoantigens.
Immunology and cell biology
Hansell CA,MacLellan LM,Oldham RS,Doonan J,Chapple KJ,Anderson EJ,Linington C,McInnes IB,Nibbs RJ,Goodyear CS
14-0453 was used in Flow cytometry/Cell sorting to investigate the role of ACKR2 in autoimmunity, showing that it suppresses Th17 responses to protein autoantigens.
Sun Feb 01 00:00:00 EST 2015
Dendritic Cell-Based Vaccines that Utilize Myeloid Rather than Plasmacytoid Cells Offer a Superior Survival Advantage in Malignant Glioma.
Journal of immunology (Baltimore, Md. : 1950)
Dey M,Chang AL,Miska J,Wainwright DA,Ahmed AU,Balyasnikova IV,Pytel P,Han Y,Tobias A,Zhang L,Qiao J,Lesniak MS
14-0453 was used in Flow cytometry/Cell sorting to compare the ability of myeloid and plasmacytoid dendritic cells to generate effective antiglioma immunity.
Wed Jul 01 00:00:00 EDT 2015
OX40- and CD27-mediated costimulation synergizes with anti-PD-L1 blockade by forcing exhausted CD8+ T cells to exit quiescence.
Journal of immunology (Baltimore, Md. : 1950)
Buchan S,Manzo T,Flutter B,Rogel A,Edwards N,Zhang L,Sivakumaran S,Ghorashian S,Carpenter B,Bennett C,Freeman GJ,Sykes M,Croft M,Al-Shamkhani A,Chakraverty R
14-0453 was used in Flow cytometry/Cell sorting to study how CD27-mediated co-stimulation can synergise with co-inhibitory checkpoint blockade to switch off molecular programs for quiescence in exhausted T cell populations.
Thu Jan 01 00:00:00 EST 2015
PI3Kδ Regulates the Magnitude of CD8+ T Cell Responses after Challenge with Listeria monocytogenes.
Journal of immunology (Baltimore, Md. : 1950)
Pearce VQ,Bouabe H,MacQueen AR,Carbonaro V,Okkenhaug K
14-0453 was used in Flow cytometry/Cell sorting to investigate the effect of inhibition of the p110δ subunit of PI3Kδ on CD8(+) T cell responses to Listeria monocytogenes infection.
Thu Oct 01 00:00:00 EDT 2015
Alternatively activated macrophages promote pancreatic fibrosis in chronic pancreatitis.
Nature communications
Xue J,Sharma V,Hsieh MH,Chawla A,Murali R,Pandol SJ,Habtezion A
Published figure using CD45.1 monoclonal antibody (Product # 14-0453-82) in Flow Cytometry
Mon May 18 00:00:00 EDT 2015
Small-molecule inhibitors targeting INK4 protein p18(INK4C) enhance ex vivo expansion of haematopoietic stem cells.
Nature communications
Gao Y,Yang P,Shen H,Yu H,Song X,Zhang L,Zhang P,Cheng H,Xie Z,Hao S,Dong F,Ma S,Ji Q,Bartlow P,Ding Y,Wang L,Liu H,Li Y,Cheng H,Miao W,Yuan W,Yuan Y,Cheng T,Xie XQ
14-0453 was used in Flow cytometry/Cell sorting to investigate how putative small-molecule inhibitors for p18 protein are valuable for further dissecting the signalling pathways of stem cell self-renewal.
Wed Feb 18 00:00:00 EST 2015
CCR7-dependent trafficking of RORγ⁺ ILCs creates a unique microenvironment within mucosal draining lymph nodes.
Nature communications
Mackley EC,Houston S,Marriott CL,Halford EE,Lucas B,Cerovic V,Filbey KJ,Maizels RM,Hepworth MR,Sonnenberg GF,Milling S,Withers DR
14-0453 was used in Flow cytometry/Cell sorting to investigate whether group 3 innate lymphoid cells migrate from their mucosal and peripheral sites to local draining secondary lymphoid tissues.
Fri Jan 09 00:00:00 EST 2015
Functional classification of memory CD8(+) T cells by CX3CR1 expression.
Nature communications
Böttcher JP,Beyer M,Meissner F,Abdullah Z,Sander J,Höchst B,Eickhoff S,Rieckmann JC,Russo C,Bauer T,Flecken T,Giesen D,Engel D,Jung S,Busch DH,Protzer U,Thimme R,Mann M,Kurts C,Schultze JL,Kastenmüller W,Knolle PA
14-0453 was used in Flow cytometry/Cell sorting to demonstrate that the fractalkine-receptor distinguishes memory CD8(+) T cells with cytotoxic effector function from those with proliferative capacity.
Fri Sep 25 00:00:00 EDT 2015
Deficient Natural Killer Dendritic Cell Responses Underlay the Induction of Theiler's Virus-Induced Autoimmunity.
mBio
Chastain EM,Getts DR,Miller SD
14-0453 was used in Flow cytometry/Cell sorting to determine that disease-susceptible SJL/J mice lacked a unique innate immune population, which plays a role in early CNS virus clearance.
Tue Aug 04 00:00:00 EDT 2015
Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction.
Nature communications
Rouhani SJ,Eccles JD,Riccardi P,Peske JD,Tewalt EF,Cohen JN,Liblau R,Mäkinen T,Engelhard VH
14-0453 was used in Flow cytometry/Cell sorting to demonstrate that when β-galactosidase (β-gal) is expressed in LECs, β-gal-specific CD8 T cells undergo deletion via the PD-1/PD-L1 and LAG-3/MHC-II pathways.
Fri Apr 10 00:00:00 EDT 2015
Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages.
Cell
Haldar M,Kohyama M,So AY,Kc W,Wu X,Briseño CG,Satpathy AT,Kretzer NM,Arase H,Rajasekaran NS,Wang L,Egawa T,Igarashi K,Baltimore D,Murphy TL,Murphy KM
Published figure using CD45.1 monoclonal antibody (Product # 14-0453-82) in Flow Cytometry
Thu Mar 13 00:00:00 EDT 2014
Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia.
Nature genetics
Zimdahl B,Ito T,Blevins A,Bajaj J,Konuma T,Weeks J,Koechlein CS,Kwon HY,Arami O,Rizzieri D,Broome HE,Chuah C,Oehler VG,Sasik R,Hardiman G,Reya T
14-0453 was used in Flow cytometry/Cell sorting to show that Lis1 is critically required for the development of the haematopoietic system.
Sat Mar 01 00:00:00 EST 2014
The E3 ubiquitin ligase Itch is required for the differentiation of follicular helper T cells.
Nature immunology
Xiao N,Eto D,Elly C,Peng G,Crotty S,Liu YC
14-0453 was used in Flow cytometry/Cell sorting to investigate the molecular mechanisms that regulate the induction of T(FH) cells, showing that Itch is required.
Tue Jul 01 00:00:00 EDT 2014
In utero depletion of fetal hematopoietic stem cells improves engraftment after neonatal transplantation in mice.
Blood
Derderian SC,Togarrati PP,King C,Moradi PW,Reynaud D,Czechowicz A,Weissman IL,MacKenzie TC
14-0453 was used in Flow cytometry/Cell sorting to develop a successful foetal conditioning strategy associated with minimal toxicity.
Thu Aug 07 00:00:00 EDT 2014
WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner.
The Journal of experimental medicine
Xia P,Wang S,Huang G,Zhu P,Li M,Ye B,Du Y,Fan Z
Published figure using CD45.1 monoclonal antibody (Product # 14-0453-82) in Flow Cytometry
Mon Sep 22 00:00:00 EDT 2014
Progressive replacement of embryo-derived cardiac macrophages with age.
The Journal of experimental medicine
Molawi K,Wolf Y,Kandalla PK,Favret J,Hagemeyer N,Frenzel K,Pinto AR,Klapproth K,Henri S,Malissen B,Rodewald HR,Rosenthal NA,Bajenoff M,Prinz M,Jung S,Sieweke MH
14-0453 was used in Flow cytometry/Cell sorting to report that the embryo-derived population of cardiac macrophages is progressively substituted for monocyte-derived macrophages within the first weeks after birth.
Mon Oct 20 00:00:00 EDT 2014
Basophils regulate the recruitment of eosinophils in a murine model of irritant contact dermatitis.
The Journal of allergy and clinical immunology
Nakashima C,Otsuka A,Kitoh A,Honda T,Egawa G,Nakajima S,Nakamizo S,Arita M,Kubo M,Miyachi Y,Kabashima K
14-0453 was used in Flow cytometry/Cell sorting to clarify the roles of eosinophils in irritant contact dermatitis and the underlying mechanism of eosinophil infiltration of the skin.
Tue Jul 01 00:00:00 EDT 2014
Ag-presenting CpG-activated pDCs prime Th17 cells that induce tumor regression.
Cancer research
Guéry L,Dubrot J,Lippens C,Brighouse D,Malinge P,Irla M,Pot C,Reith W,Waldburger JM,Hugues S
14-0453 was used in Flow cytometry/Cell sorting to investigate the role of Ag-presenting CpG-activated pDCs in Th17 differentiation and antitumor immunity.
Sat Nov 15 00:00:00 EST 2014
Immune-based antitumor effects of BRAF inhibitors rely on signaling by CD40L and IFNγ.
Cancer research
Ho PC,Meeth KM,Tsui YC,Srivastava B,Bosenberg MW,Kaech SM
14-0453 was used in Flow cytometry/Cell sorting to investigate whether B-Raf(V600E) inhibitors promote tumor regression with the help of host immunity, showing that they rely on signaling by CD40L and IFNγ.
Sun Jun 15 00:00:00 EDT 2014
CCL2/CCR2-dependent recruitment of functional antigen-presenting cells into tumors upon chemotherapy.
Cancer research
Ma Y,Mattarollo SR,Adjemian S,Yang H,Aymeric L,Hannani D,Portela Catani JP,Duret H,Teng MW,Kepp O,Wang Y,Sistigu A,Schultze JL,Stoll G,Galluzzi L,Zitvogel L,Smyth MJ,Kroemer G
14-0453 was used in Flow cytometry/Cell sorting to underscore the importance of the CCL2/CCR2 signaling axis for therapeutic anticancer immune responses as elicited by immunogenic chemotherapy.
Wed Jan 15 00:00:00 EST 2014
Modulation of distinct asthmatic phenotypes in mice by dose-dependent inhalation of microbial products.
Environmental health perspectives
Whitehead GS,Thomas SY,Cook DN
14-0453 was used in Flow cytometry/Cell sorting to assess pulmonary cytokine production and airway inflammation following challenge with ovalbumin and LPS.
Wed Jan 01 00:00:00 EST 2014
γδ T cells restrain extrathymic development of Foxp3+-inducible regulatory T cells via IFN-γ.
European journal of immunology
Visperas A,Shen B,Min B
14-0453 was used in Flow cytometry/Cell sorting to reveal a novel function of γδ T cells in limiting the generation of iTreg cells, potentially balancing immunity and tolerance.
Fri Aug 01 00:00:00 EDT 2014
Colitogenic effector T cells: roles of gut-homing integrin, gut antigen specificity and γδ T cells.
Immunology and cell biology
Do JS,Visperas A,Freeman ML,Iwakura Y,Oukka M,Min B
14-0453 was used in Flow cytometry/Cell sorting to demonstrate that T-cell colitogenicity is achieved through multiple processes, offering a therapeutic rationale by intervening these pathways.
Wed Jan 01 00:00:00 EST 2014
CX3CR1 delineates temporally and functionally distinct subsets of myeloid-derived suppressor cells in a mouse model of ovarian cancer.
Immunology and cell biology
Hart KM,Usherwood EJ,Berwin BL
14-0453 was used in Flow cytometry/Cell sorting to investigate a novel nongranulocytic CX3CR1-negative myeloid population.
Tue Jul 01 00:00:00 EDT 2014
Cutting edge: CD8+ recent thymic emigrants exhibit increased responses to low-affinity ligands and improved access to peripheral sites of inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Berkley AM,Fink PJ
14-0453-82 was used in Flow Cytometry to investigate if the maturation state of peripheral T cells impacts the response to bacterial infection due to intrinsic differences in TCR signaling.
Wed Oct 01 00:00:00 EDT 2014
IRF4 in dendritic cells inhibits IL-12 production and controls Th1 immune responses against Leishmania major.
Journal of immunology (Baltimore, Md. : 1950)
Akbari M,Honma K,Kimura D,Miyakoda M,Kimura K,Matsuyama T,Yui K
14-0453 was used in Flow cytometry/Cell sorting to investigate the roles of the transcription factor IRF4 in dendritic cells and macrophages in vivo.
Sat Mar 01 00:00:00 EST 2014
CXCR4 is dispensable for T cell egress from chronically inflamed skin via the afferent lymph.
PloS one
Geherin SA,Wilson RP,Jennrich S,Debes GF
14-0453 was used in Flow cytometry/Cell sorting to assess the role of CXCR4 for T cell egress from chronically inflamed skin.
Wed Jan 14 00:00:00 EST 2015
Local proliferation dominates lesional macrophage accumulation in atherosclerosis.
Nature medicine
Robbins CS,Hilgendorf I,Weber GF,Theurl I,Iwamoto Y,Figueiredo JL,Gorbatov R,Sukhova GK,Gerhardt LM,Smyth D,Zavitz CC,Shikatani EA,Parsons M,van Rooijen N,Lin HY,Husain M,Libby P,Nahrendorf M,Weissleder R,Swirski FK
14-0453 was used in Immunohistochemistry to study the underlying molecular mechanisms of macrophage accumulation in atherosclerosis.
Sun Sep 01 00:00:00 EDT 2013
Hematopoietic progenitor cell lines with myeloid and lymphoid potential.
Nature methods
Redecke V,Wu R,Zhou J,Finkelstein D,Chaturvedi V,High AA,Häcker H
14-0453 was used in Flow cytometry/Cell sorting to develop methods to investigate immune-cell differentiation and function, showing that immortalised hematopoietic progenitor cell lines can be produced, with myeloid and lymphoid potential.
Thu Aug 01 00:00:00 EDT 2013
Anatomically restricted synergistic antiviral activities of innate and adaptive immune cells in the skin.
Cell host & microbe
Hickman HD,Reynoso GV,Ngudiankama BF,Rubin EJ,Magadán JG,Cush SS,Gibbs J,Molon B,Bronte V,Bennink JR,Yewdell JW
14-0453 was used in Flow cytometry/Cell sorting to explore the spatiotemporal organization between antiviral immune cells and vaccinia virus-infected murine cells.
Wed Feb 13 00:00:00 EST 2013
Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4⁺ T cell immunity.
Nature immunology
Reis BS,Rogoz A,Costa-Pinto FA,Taniuchi I,Mucida D
Published figure using CD45.1 monoclonal antibody (Product # 14-0453-82) in Flow Cytometry
Fri Mar 01 00:00:00 EST 2013
The microRNA miR-155 controls CD8(+) T cell responses by regulating interferon signaling.
Nature immunology
Gracias DT,Stelekati E,Hope JL,Boesteanu AC,Doering TA,Norton J,Mueller YM,Fraietta JA,Wherry EJ,Turner M,Katsikis PD
14-0453 was used in Flow cytometry/Cell sorting to study the role of miR-155 in the regulation of CD8(+) T cell interferon responses to pathogens in vivo.
Sat Jun 01 00:00:00 EDT 2013
Nrf2 regulates haematopoietic stem cell function.
Nature cell biology
Tsai JJ,Dudakov JA,Takahashi K,Shieh JH,Velardi E,Holland AM,Singer NV,West ML,Smith OM,Young LF,Shono Y,Ghosh A,Hanash AM,Tran HT,Moore MA,van den Brink MR
14-0453 was used in Flow cytometry/Cell sorting to investigate the link between Nrf2 and CXCR4, thought to partially contribute to the maintenance of haematopoietic stem cell function.
Fri Mar 01 00:00:00 EST 2013
IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis.
The Journal of clinical investigation
Huber M,Heink S,Pagenstecher A,Reinhard K,Ritter J,Visekruna A,Guralnik A,Bollig N,Jeltsch K,Heinemann C,Wittmann E,Buch T,Prazeres da Costa O,Brüstle A,Brenner D,Mak TW,Mittrücker HW,Tackenberg B,Kamradt T,Lohoff M
14-0453 was used in Flow cytometry/Cell sorting to investigate the role of IL-17-producing CD8+ T cells in multiple sclerosis using a murine model.
Tue Jan 01 00:00:00 EST 2013
Gata2 cis-element is required for hematopoietic stem cell generation in the mammalian embryo.
The Journal of experimental medicine
Gao X,Johnson KD,Chang YI,Boyer ME,Dewey CN,Zhang J,Bresnick EH
14-0453 was used in Flow cytometry/Cell sorting to investigate the role of Gata2 cis-element in generation of hematopoietic stem cells.
Mon Dec 16 00:00:00 EST 2013
Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation.
eLife
Kerenyi MA,Shao Z,Hsu YJ,Guo G,Luc S,O'Brien K,Fujiwara Y,Peng C,Nguyen M,Orkin SH
14-0453 was used in Flow cytometry/Cell sorting to study how Lsd1-mediated concurrent repression of enhancer and promoter activity of stem and progenitor cell genes is a pivotal epigenetic mechanism required for proper hematopoietic maturation.
Tue Jun 18 00:00:00 EDT 2013
Arrayed lentiviral barcoding for quantification analysis of hematopoietic dynamics.
Stem cells (Dayton, Ohio)
Grosselin J,Sii-Felice K,Payen E,Chretien S,Tronik-Le Roux D,Leboulch P
Published figure using CD45.1 monoclonal antibody (Product # 14-0453-82) in Flow Cytometry
Tue Oct 01 00:00:00 EDT 2013
Impaired neutrophil function in 24p3 null mice contributes to enhanced susceptibility to bacterial infections.
Journal of immunology (Baltimore, Md. : 1950)
Liu Z,Petersen R,Devireddy L
14-0453 was used in Flow cytometry/Cell sorting to show that lipocalin 24p3(-/-) mice are defective in immune function.
Wed May 01 00:00:00 EDT 2013
An enhancer element harboring variants associated with systemic lupus erythematosus engages the TNFAIP3 promoter to influence A20 expression.
PLoS genetics
Wang S,Wen F,Wiley GB,Kinter MT,Gaffney PM
14-0453 was used in Western Blotting to reveal a novel mechanism of TNFAIP3 transcriptional regulation and establish how the TT>A risk variants attenuate A20 expression.
Fri Mar 21 00:00:00 EDT 2014
T-Bet and Eomes Regulate the Balance between the Effector/Central Memory T Cells versus Memory Stem Like T Cells.
PloS one
Li G,Yang Q,Zhu Y,Wang HR,Chen X,Zhang X,Lu B
14-0453 was used in Flow cytometry/Cell sorting to investigate the role of T-bet and Eomes in shaping the memory T cell pool.
Tue Oct 10 00:00:00 EDT 2017
Bone marrow and nonbone marrow Toll like receptor 4 regulate acute hepatic injury induced by endotoxemia.
PloS one
Hochhauser E,Avlas O,Fallach R,Bachmetov L,Zemel R,Pappo O,Shainberg A,Ben Ari Z
14-0453 was used in Flow cytometry/Cell sorting to suggest that the absence of the TLR4 gene plays a pivotal role in reducing hepatic lipopolysaccharide (LPS) induced injury.
Thu Jan 15 00:00:00 EST 2015
Low-affinity T cells are programmed to maintain normal primary responses but are impaired in their recall to low-affinity ligands.
Cell reports
Knudson KM,Goplen NP,Cunningham CA,Daniels MA,Teixeiro E
14-0453 was used in Flow cytometry/Cell sorting to demonstrate that distinct mechanisms drive effector/memory development in high- and low-affinity T-cells.
Thu Aug 15 00:00:00 EDT 2013
A self-help program for memory CD8+ T cells: positive feedback via CD40-CD40L signaling as a critical determinant of secondary expansion.
PloS one
Shugart JA,Bambina S,Alice AF,Montler R,Bahjat KS
14-0453 was used in Flow cytometry/Cell sorting to demonstrate that vaccination regimens differ in their dependence on CD40L-expressing CD8+ T cells for secondary expansion.
Tue Jan 07 00:00:00 EST 2014
The receptor Ly108 functions as a SAP adaptor-dependent on-off switch for T cell help to B cells and NKT cell development.
Immunity
Kageyama R,Cannons JL,Zhao F,Yusuf I,Lao C,Locci M,Schwartzberg PL,Crotty S
14-0453 was used in Flow cytometry/Cell sorting to investigate the mechanisms underlying the defects in humoural immunity present in humans and mice deficient in the adaptor protein, SAP.
Fri Jun 29 00:00:00 EDT 2012
Molecular definition of the identity and activation of natural killer cells.
Nature immunology
Bezman NA,Kim CC,Sun JC,Min-Oo G,Hendricks DW,Kamimura Y,Best JA,Goldrath AW,Lanier LL
14-0453 was used in Flow cytometry/Cell sorting to systematically define the transcriptome of mouse natural killer cells in several contexts.
Mon Oct 01 00:00:00 EDT 2012
TGF-β signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation.
Nature immunology
Zhang N,Bevan MJ
14-0453 was used in Flow cytometry/Cell sorting to propose that TGF-β signaling controls the self-reactivity of peripheral T cells but that in the absence of TGF-β signals, an added trigger such as lymphopenia is needed to drive overt autoimmune disease.
Sun May 27 00:00:00 EDT 2012
Kruppel-like factor 7 overexpression suppresses hematopoietic stem and progenitor cell function.
Blood
Schuettpelz LG,Gopalan PK,Giuste FO,Romine MP,van Os R,Link DC
14-0453 was used in Flow cytometry/Cell sorting to investigate the role of kruppel-like factor 7 in hematopoietic stem and progenitor cell function.
Thu Oct 11 00:00:00 EDT 2012
Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice.
The Journal of experimental medicine
Billiard F,Lobry C,Darrasse-Jèze G,Waite J,Liu X,Mouquet H,DaNave A,Tait M,Idoyaga J,Leboeuf M,Kyratsous CA,Burton J,Kalter J,Klinakis A,Zhang W,Thurston G,Merad M,Steinman RM,Murphy AJ,Yancopoulos GD,Aifantis I,Skokos D
14-0453 was used in Flow cytometry/Cell sorting to investigate how Dll4-Notch signaling affects pro-T cell fate and thymic DC development, showing that it is a novel Flt3-independent pathway for DC development and autoimmunity.
Mon May 07 00:00:00 EDT 2012
Unexpected role for MHC II-peptide complexes in shaping CD8 T-cell expansion and differentiation in vivo.
Proceedings of the National Academy of Sciences of the United States of America
Do JS,Valujskikh A,Vignali DA,Fairchild RL,Min B
14-0453 was used in Flow cytometry/Cell sorting to reveal a previously undefined MHC II-dependent regulation that tunes CD8 T-cell reactivity.
Tue Jul 31 00:00:00 EDT 2012
The bone marrow functions as the central site of proliferation for long-lived NK cells.
Journal of immunology (Baltimore, Md. : 1950)
van Helden MJ,de Graaf N,Boog CJ,Topham DJ,Zaiss DM,Sijts AJ
14-0453 was used in Flow cytometry/Cell sorting to investigate the dynamics of natural killer cell responses after intranasal respiratory virus infection in mice.
Sat Sep 01 00:00:00 EDT 2012
In vitro Ag Cross-presentation and in vivo Ag Cross-presentation by Dendritic Cells in the Mouse.
Bio-protocol
Ghosh M,Shapiro LH
Published figure using CD45.1 monoclonal antibody (Product # 14-0453-82) in Flow Cytometry
Thu Dec 20 00:00:00 EST 2012
CCR2 defines a distinct population of NK cells and mediates their migration during influenza virus infection in mice.
PloS one
van Helden MJ,Zaiss DM,Sijts AJ
14-0453 was used in Flow cytometry/Cell sorting to determine the role of CCR2 in NK cell migration during intranasal influenza virus infection, showing that it defines a distinct population of NK cells and mediates their migration.
Mon Jun 10 00:00:00 EDT 2013
Extra-thymic physiological T lineage progenitor activity is exclusively confined to cells expressing either CD127, CD90, or high levels of CD117.
PloS one
Saran N,Pommerencke J,Witzlau K,Regelin M,Krueger A
14-0453 was used in Flow cytometry/Cell sorting to suggest that a physiological thymic microenvironment does not optimally support T cell differentiation from triple negative precursors.
Mon Jun 18 00:00:00 EDT 2012
Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus.
Nature genetics
Adrianto I,Wen F,Templeton A,Wiley G,King JB,Lessard CJ,Bates JS,Hu Y,Kelly JA,Kaufman KM,Guthridge JM,Alarcón-Riquelme ME,Anaya JM,Bae SC,Bang SY,Boackle SA,Brown EE,Petri MA,Gallant C,Ramsey-Goldman R,Reveille JD,Vila LM,Criswell LA,Edberg JC,Freedman BI,Gregersen PK,Gilkeson GS,Jacob CO,James JA,Kamen DL,Kimberly RP,Martin J,Merrill JT,Niewold TB,Park SY,Pons-Estel BA,Scofield RH,Stevens AM,Tsao BP,Vyse TJ,Langefeld CD,Harley JB,Moser KL,Webb CF,Humphrey MB,Montgomery CG,Gaffney PM
14-0453 was used in Western Blotting to characterise the TNFAIP3 risk haplotype, and identify a polymorphic dinucleotide associated with systemic lupus erythematosus in subjects of European and Korean ancestry.
Tue Mar 01 00:00:00 EST 2011
Delivery of progenitors to the thymus limits T-lineage reconstitution after bone marrow transplantation.
Blood
Zlotoff DA,Zhang SL,De Obaldia ME,Hess PR,Todd SP,Logan TD,Bhandoola A
14-0453 was used in Flow cytometry/Cell sorting to explain why T cells are among the last of the hematopoietic lineages to recover after bone marrow transplantation (BMT).
Thu Aug 18 00:00:00 EDT 2011
Recent thymic emigrants are biased against the T-helper type 1 and toward the T-helper type 2 effector lineage.
Blood
Hendricks DW,Fink PJ
14-0453 was used in Flow cytometry/Cell sorting to investigate the relationships between recent thymic emigrants and T-helper type 1 and 2 cells.
Thu Jan 27 00:00:00 EST 2011
Maternal T cells limit engraftment after in utero hematopoietic cell transplantation in mice.
The Journal of clinical investigation
Nijagal A,Wegorzewska M,Jarvis E,Le T,Tang Q,MacKenzie TC
14-0453 was used in Flow cytometry/Cell sorting to investigate whether maternal cells trafficking into the fetus impose the barrier to effective in utero hematopoietic cell transplantation, showing that maternal T cells limit engraftment.
Tue Feb 01 00:00:00 EST 2011
Chemokines control naive CD8+ T cell selection of optimal lymph node antigen presenting cells.
The Journal of experimental medicine
Hickman HD,Li L,Reynoso GV,Rubin EJ,Skon CN,Mays JW,Gibbs J,Schwartz O,Bennink JR,Yewdell JW
14-0453 was used in Flow cytometry/Cell sorting to demonstrate the ability of chemokines to assist antiviral CD8(+) T cells in distinguishing between antigen presenting cells.
Mon Nov 21 00:00:00 EST 2011
Interleukin 37 expression protects mice from colitis.
Proceedings of the National Academy of Sciences of the United States of America
McNamee EN,Masterson JC,Jedlicka P,McManus M,Grenz A,Collins CB,Nold MF,Nold-Petry C,Bufler P,Dinarello CA,Rivera-Nieves J
14-0453 was used in Flow cytometry/Cell sorting to investigate how IL-37 emerged as a key modulator of intestinal inflammation.
Tue Oct 04 00:00:00 EDT 2011
Blockade of CTLA-4 decreases the generation of multifunctional memory CD4+ T cells in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Rudolph M,Hebel K,Miyamura Y,Maverakis E,Brunner-Weinzierl MC
14-0453 was used in Flow cytometry/Cell sorting to investigate the role of CTLA-4 on memory formation of adaptive immune responses using anti-CTLA-4 mAb treatment in mice.
Sun May 15 00:00:00 EDT 2011
Cutting edge: Generation of colitogenic Th17 CD4 T cells is enhanced by IL-17+ γδ T cells.
Journal of immunology (Baltimore, Md. : 1950)
Do JS,Visperas A,Dong C,Baldwin WM,Min B
14-0453 was used in Flow cytometry/Cell sorting to elucidate a cellular mechanism by which colitogenic Th17 immunity arises in vivo.
Fri Apr 15 00:00:00 EDT 2011
Exploiting the role of endogenous lymphoid-resident dendritic cells in the priming of NKT cells and CD8+ T cells to dendritic cell-based vaccines.
PloS one
Petersen TR,Sika-Paotonu D,Knight DA,Simkins HM,Hermans IF
14-0453 was used in Flow cytometry/Cell sorting to investigate whether transfer of antigen between APCs is a mechanism to spread antigen to cells with specialised stimulatory functions.
Thu Mar 31 00:00:00 EDT 2011
Zinc supplementation alters airway inflammation and airway hyperresponsiveness to a common allergen.
Journal of inflammation (London, England)
Morgan CI,Ledford JR,Zhou P,Page K
14-0453 was used in Western Blotting to suggest that zinc supplementation alters NF-κB activity via alteration of A20 activity.
Wed Dec 07 00:00:00 EST 2011
The metalloprotease-disintegrin ADAM8 is essential for the development of experimental asthma.
American journal of respiratory and critical care medicine
Naus S,Blanchet MR,Gossens K,Zaph C,Bartsch JW,McNagny KM,Ziltener HJ
14-0453 was used in Flow cytometry/Cell sorting to determine that ADAM8 plays a crucial proinflammatory role in airway inflammation.
Tue Jun 15 00:00:00 EDT 2010
The Apc(min) mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS.
Blood
Lane SW,Sykes SM,Al-Shahrour F,Shterental S,Paktinat M,Lo Celso C,Jesneck JL,Ebert BL,Williams DA,Gilliland DG
14-0453 was used in Flow cytometry/Cell sorting to reveal that Wnt activation through haploinsufficiency of Apc causes insidious loss of HSC function.
Thu Apr 29 00:00:00 EDT 2010
Efficient and versatile manipulation of the peripheral CD4+ T-cell compartment by antigen targeting to DNGR-1/CLEC9A.
European journal of immunology
Joffre OP,Sancho D,Zelenay S,Keller AM,Reis e Sousa C
14-0453 was used in Flow cytometry/Cell sorting to show that antigen targeting to DNGR-1 is a versatile approach for inducing functionally distinct CD4+ T-cell responses.
Sat May 01 00:00:00 EDT 2010
Pathological features of heterologous immunity are regulated by the private specificities of the immune repertoire.
The American journal of pathology
Nie S,Lin SJ,Kim SK,Welsh RM,Selin LK
14-0453 was used in Flow cytometry/Cell sorting to show that virus-induced immunopathology under conditions of heterologous immunity is a function of the private specificity of the immune repertoire.
Sat May 01 00:00:00 EDT 2010
ATP-binding cassette transporter G1 negatively regulates thymocyte and peripheral lymphocyte proliferation.
Journal of immunology (Baltimore, Md. : 1950)
Armstrong AJ,Gebre AK,Parks JS,Hedrick CC
14-0453 was used in Flow cytometry/Cell sorting to demonstrate that ATP-binding cassette transporter G1 regulates cholesterol homeostasis in thymocytes and peripheral CD4 T cells.
Fri Jan 01 00:00:00 EST 2010
The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation.
Nature immunology
Koch MA,Tucker-Heard G,Perdue NR,Killebrew JR,Urdahl KB,Campbell DJ
14-0453 was used in Flow cytometry/Cell sorting to study how in a subset of CD4(+) T cells, the activities of the transcription factors Foxp3 and T-bet are overlaid.
Mon Jun 01 00:00:00 EDT 2009
Cognate CD4 help is essential for the reactivation and expansion of CD8 memory T cells directed against the hematopoietic cell-specific dominant minor histocompatibility antigen, H60.
Blood
Ryu SJ,Jung KM,Yoo HS,Kim TW,Kim S,Chang J,Choi EY
14-0453 was used in Flow cytometry/Cell sorting to provide insight into the control of minor H antigen-specific CD8 T-cell responses, to maximize the graft-versus-leukemia response.
Thu Apr 30 00:00:00 EDT 2009
AID constrains germinal center size by rendering B cells susceptible to apoptosis.
Blood
Zaheen A,Boulianne B,Parsa JY,Ramachandran S,Gommerman JL,Martin A
14-0453 was used in Flow cytometry/Cell sorting to report a link between AID-induced DNA damage and B-cell apoptosis that has implications for the development of B-cell disorders.
Thu Jul 16 00:00:00 EDT 2009
Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia.
Blood
Guibal FC,Alberich-Jorda M,Hirai H,Ebralidze A,Levantini E,Di Ruscio A,Zhang P,Santana-Lemos BA,Neuberg D,Wagers AJ,Rego EM,Tenen DG
14-0453 was used in Flow cytometry/Cell sorting to provide further understanding of the biology of APL by demonstrating that a committed transformed progenitor can propagate the disease.
Thu Dec 24 00:00:00 EST 2009
Differential requirements of MHC and of DCs for endogenous proliferation of different T-cell subsets in vivo.
Proceedings of the National Academy of Sciences of the United States of America
Do JS,Min B
14-0453 was used in Flow cytometry/Cell sorting to investigate the conditions and requirements of MHC and DCs for endogenous proliferation of different T-cell subsets.
Tue Dec 01 00:00:00 EST 2009
Coxsackievirus B3 inhibits antigen presentation in vivo, exerting a profound and selective effect on the MHC class I pathway.
PLoS pathogens
Kemball CC,Harkins S,Whitmire JK,Flynn CT,Feuer R,Whitton JL
14-0453 was used in Flow cytometry/Cell sorting to evaluate in vitro and in vivo antigen presentation by coxsackievirus B3, showing that it inhibits antigen presentation in vivo.
Thu Oct 01 00:00:00 EDT 2009
Mice deficient in stem cell antigen-1 (Sca1, Ly-6A/E) develop normal primary and memory CD4+ and CD8+ T-cell responses to virus infection.
European journal of immunology
Whitmire JK,Eam B,Whitton JL
14-0453 was used in Flow cytometry/Cell sorting to evaluate the requirement for Sca1 in the T-cell response to viral infection.
Mon Jun 01 00:00:00 EDT 2009
Chronic CD70-driven costimulation impairs IgG responses by instructing T cells to inhibit germinal center B cell formation through FasL-Fas interactions.
Journal of immunology (Baltimore, Md. : 1950)
Beishuizen CR,Kragten NA,Boon L,Nolte MA,van Lier RA,van Gisbergen KP
14-0453 was used in Flow cytometry/Cell sorting to investigate the mechanism by which CD70 expression induces T cell-driven disruption of neutralising Ab responses, showing that this occurs by instructing T cells to inhibit germinal center B cell formation.
Sun Nov 15 00:00:00 EST 2009
Chronic CD70-driven costimulation impairs IgG responses by instructing T cells to inhibit germinal center B cell formation through FasL-Fas interactions.
Journal of immunology (Baltimore, Md. : 1950)
Beishuizen CR,Kragten NA,Boon L,Nolte MA,van Lier RA,van Gisbergen KP
14-0453 was used in Flow cytometry/Cell sorting to investigate the mechanism by which CD70 expression induces T cell-driven disruption of neutralising Ab responses, showing that this occurs by instructing T cells to inhibit germinal center B cell formation.
Sun Nov 15 00:00:00 EST 2009
GITR triggering induces expansion of both effector and regulatory CD4+ T cells in vivo.
Journal of immunology (Baltimore, Md. : 1950)
van Olffen RW,Koning N,van Gisbergen KP,Wensveen FM,Hoek RM,Boon L,Hamann J,van Lier RA,Nolte MA
14-0453 was used in Flow cytometry/Cell sorting to study the role of glucocorticoid-induced TNF receptor family-related protein on activated and regulatory T cells.
Mon Jun 15 00:00:00 EDT 2009
CCR7 ligands are required for development of experimental autoimmune encephalomyelitis through generating IL-23-dependent Th17 cells.
Journal of immunology (Baltimore, Md. : 1950)
Kuwabara T,Ishikawa F,Yasuda T,Aritomi K,Nakano H,Tanaka Y,Okada Y,Lipp M,Kakiuchi T
14-0453 was used in Flow cytometry/Cell sorting to deduce the role of CCL19 and CCL21 in inducing experimental autoimmune encephalomyelitis.
Sat Aug 15 00:00:00 EDT 2009
The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues.
Nature immunology
Waskow C,Liu K,Darrasse-Jèze G,Guermonprez P,Ginhoux F,Merad M,Shengelia T,Yao K,Nussenzweig M
14-0453-82 was used in Immunohistochemistry to investigate the hematopoietic growth factors regulating dendritic development.
Sun Jun 01 00:00:00 EDT 2008
The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues.
Nature immunology
Waskow C,Liu K,Darrasse-Jèze G,Guermonprez P,Ginhoux F,Merad M,Shengelia T,Yao K,Nussenzweig M
14-0453-82 was used in Immunohistochemistry to investigate the hematopoietic growth factors regulating dendritic development.
Sun Jun 01 00:00:00 EDT 2008
CD40L+ CD4+ memory T cells migrate in a CD62P-dependent fashion into reactive lymph nodes and license dendritic cells for T cell priming.
The Journal of experimental medicine
Martín-Fontecha A,Baumjohann D,Guarda G,Reboldi A,Hons M,Lanzavecchia A,Sallusto F
14-0453 was used in Flow cytometry/Cell sorting to show that T(EM) cells can behave as endogenous adjuvants.
Mon Oct 27 00:00:00 EDT 2008
Dendritic cells and B cells maximize mucosal Th1 memory response to herpes simplex virus.
The Journal of experimental medicine
Iijima N,Linehan MM,Zamora M,Butkus D,Dunn R,Kehry MR,Laufer TM,Iwasaki A
14-0453 was used in Immunofluorescence to investigate the antiviral mechanism of Th1, showing that dendritic cells and B cells maximise mucosal Th1 memory response to herpes simplex virus.
Mon Dec 22 00:00:00 EST 2008
Identification of CD4int progenitors in mouse fetal spleen, a source of resident lymphoid cells.
Journal of leukocyte biology
Desanti GE,Cumano A,Golub R
14-0453 was used in Flow cytometry/Cell sorting to propose a model for fetal splenic hematopoietic progenitors and their distribution.
Thu May 01 00:00:00 EDT 2008
Increasing the CD4+ T cell precursor frequency leads to competition for IFN-gamma thereby degrading memory cell quantity and quality.
Journal of immunology (Baltimore, Md. : 1950)
Whitmire JK,Benning N,Eam B,Whitton JL
14-0453 was used in Flow cytometry/Cell sorting to investigate the relationship between the frequency of CD4(+) T cells and memory cells generated, showing that increased frequency leads to competition for IFN-gamma thereby degrading memory cell quantity and quality.
Thu May 15 00:00:00 EDT 2008
Elimination of antigen-presenting cells and autoreactive T cells by Fas contributes to prevention of autoimmunity.
Immunity
Stranges PB,Watson J,Cooper CJ,Choisy-Rossi CM,Stonebraker AC,Beighton RA,Hartig H,Sundberg JP,Servick S,Kaufmann G,Fink PJ,Chervonsky AV
14-0453 was used in Flow cytometry/Cell sorting to study the effects of tissue-specific Fas deletion in antigen-presenting cells or T cells on autoimmunity in mice.
Tue May 01 00:00:00 EDT 2007
Altering the distribution of Foxp3(+) regulatory T cells results in tissue-specific inflammatory disease.
The Journal of experimental medicine
Sather BD,Treuting P,Perdue N,Miazgowicz M,Fontenot JD,Rudensky AY,Campbell DJ
14-0453 was used in Flow cytometry/Cell sorting to investigate the factors which impact regulatory T cell homing receptor expression, tissue distribution and peripheral tolerance maintenance.
Mon Jun 11 00:00:00 EDT 2007
Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims MHC class I-presented peptides in vivo and plays an important role in immunodominance.
Proceedings of the National Academy of Sciences of the United States of America
York IA,Brehm MA,Zendzian S,Towne CF,Rock KL
14-0453 was used in Flow cytometry/Cell sorting to discover that ERAP1 peptide trimming and the resulting abundance of peptide-MHC complexes are dominant factors in establishing immunodominance.
Tue Jun 13 00:00:00 EDT 2006
