Immuno-Oncology Product Resource Guide
The Immuno-Oncology Product Resource Guide is an introduction to immuno-oncology research, covering key approaches such as CAR T-cell therapy research and solutions for each application area.
Comprehensive solutions for cancer genomic biomarker discovery and verification across key immuno-oncology research areas
Immuno-oncology research, aimed at discovering new cancer biomarkers that can become novel therapeutic targets, has experienced significant breakthroughs in cancer research demonstrated by the advent of checkpoint inhibitors and adoptive cell therapy as therapeutic agents. This is made possible as the scientific field continues to improve the understanding of the complex relationship between the immune system and tumor biology. A growing number of scientific articles support the implementation of new approaches to study the relationship between the immune system and tumor progression.
Characterizing tumor microenvironment biomarkers
Thermo Fisher Scientific offers the right solution for immuno-oncology related applications to help enable scientists to accelerate their research and discovery of new therapies. Discovery and development of effective cancer immunotherapy requires a better understanding of the cellular and biochemical makeup where a tumor resides, or in its microenvironment. The tumor microenvironment is a result of the physiology, the immune system, and the associated cellular and molecular factors. Dissecting the stages of tumorigenesis, from onset through cellular transformation and metastasis, requires a comprehensive knowledge of the tumor microenvironment.
Knowledge of these complex dynamics within in the cellular microenvironment is the basis for identifying a tumor’s unique biosignature, and consequently its nature. A tumor’s biosignature is the result of its relationship with the organ, tissue, or cells with which it interacts, as well as growth factors and chemokines/cytokines that affect signaling cascades. For instance, there is mounting evidence that tissue infiltrating inflammatory cells and their chemical mediators contribute to deleterious alterations in DNA, RNA, proteins, lipids, and metabolites, leading to dysregulation of normal cellular processes. Consequently, cell cycle, apoptosis, intercellular and intracellular signaling cascades are affected, often resulting in tumor formation. It is thus crucial to identify biomarkers that will pinpoint key features of a tumor that are responsible for tumorigenesis. Cancer with its many forms and unique molecular traits remains difficult to investigate without the appropriate tools. Thermo Fisher Scientific offers traditional as well as the next generation of genomic and proteomic tools for studying, analyzing, and correlating the complex interactions between the immune system, tumor, and tumor microenvironment.
Thermo Fisher Scientific can help support your cancer biomarker discovery and verification studies across key immuno-oncology research areas including CAR T-cell therapy, cancer vaccine, and checkpoint inhibitor therapy research. We have the portfolio breadth so that cancer researchers can select the right solution for a specific application, including:
Featured products
This pan-cancer gene expression assay is designed to interrogate the tumor microenvironment to enable mechanistic studies and identification of predictive biomarkers for immunotherapy.
This microarray-based whole-genome copy number assay detects a wide variety of somatic copy number aberrations (CNAs), including ploidy and chromothripsis from as little as 80 ng of FFPE-derived DNA.
A robust, targeted next-generation sequencing (NGS) assay providing clinical researchers with an accurate quantification of somatic mutation counts to assess TMB.
Explore our solutions for biomarker discovery and verification
Genomic biomarker discovery
Learn how you can identify new genomic biomarkers by interrogating the whole transcriptome.
- Clariom D Pico Assays—accelerate your biomarker discovery from deep within the transcriptome
- Clariom S Pico Assays—obtain a gene-level view of the human transcriptome
- Ion Torrent AmpliSeq Transcriptome—for differential expression and discovery of novel transcripts and exons
Genomic biomarker verification
Find tools for genomic biomarker verification of well-understood checkpoint inhibitors and immune related genes.
- Oncomine Immune Response Research Assay
- TaqMan Array Human Immune Response Plate—use a 96-well plate for quantitative gene expression analysis
- TaqMan Array Human Immune Panel—easy-to-use microfluidic cards for quantitative gene expression analysis
- TaqMan Gene Expression Assays—search for assays or design your own custom assay to study any gene
Sequencing
Learn more about our sequencing solutions, including NGS and Sanger sequencing.
- NGS using the Ion GeneStudio S5 series sequencers and the Oncomine TCR Beta-LR Assay and Oncomine TCR Beta-SR Assay
- Sanger sequencing with the SeqStudio Genetic Analyzer
Genomic biomarker discovery and verification
Discover our microarray-based whole-genome copy number assays to detect a wide variety of somatic copy number aberrations including ploidy and chromothripsis.
Learn more about our NGS based assay for the assessment of tumor mutational burden (TMB).
Genomic biomarker discovery
Learn how you can identify new genomic biomarkers by interrogating the whole transcriptome.
- Clariom D Pico Assays—accelerate your biomarker discovery from deep within the transcriptome
- Clariom S Pico Assays—obtain a gene-level view of the human transcriptome
- Ion Torrent AmpliSeq Transcriptome—for differential expression and discovery of novel transcripts and exons
Genomic biomarker verification
Find tools for genomic biomarker verification of well-understood checkpoint inhibitors and immune related genes.
- Oncomine Immune Response Research Assay
- TaqMan Array Human Immune Response Plate—use a 96-well plate for quantitative gene expression analysis
- TaqMan Array Human Immune Panel—easy-to-use microfluidic cards for quantitative gene expression analysis
- TaqMan Gene Expression Assays—search for assays or design your own custom assay to study any gene
Sequencing
Learn more about our sequencing solutions, including NGS and Sanger sequencing.
- NGS using the Ion GeneStudio S5 series sequencers and the Oncomine TCR Beta-LR Assay and Oncomine TCR Beta-SR Assay
- Sanger sequencing with the SeqStudio Genetic Analyzer
Genomic biomarker discovery and verification
Discover our microarray-based whole-genome copy number assays to detect a wide variety of somatic copy number aberrations including ploidy and chromothripsis.
Learn more about our NGS based assay for the assessment of tumor mutational burden (TMB).
Proteomic biomarker discovery and verification
Antibodies
Search our extensive portfolio of antibodies to key checkpoint markers, including:
Quantitative protein analysis
We offer quality Invitrogen immunoassays designed to help you easily quantify checkpoint protein biomarkers with confidence.
Singleplex quantitation of proteomic biomarkers
- Validated ELISA kits—complete and ready to use, designed to enable accurate protein quantitation of immune-related cancer targets. We also offer simplified workflow and high-sensitivity options.
- Robust, reliable microplate readers—from the original inventors of microplate readers, choose from a lineup of tried and true Thermo Scientific dedicated and multimode readers, all powered by the same intuitive SkanIt Software.
- ProQuantum Immunoassays—when working with very limited samples, this unique platform offers high-sensitivity with a streamlined workflow, available with popular targets used in I/O research.
Multiplex quantitation of proteomic biomarkers
- ProcartaPlex preconfigured panels—profile more biomarkers simultaneously, save time and sample
- Immuno-Oncology Checkpoint 14-Plex Human ProcartaPlex Panel 1—custom mix for I/O research
- Immuno-Oncology Checkpoint 14-Plex Human ProcartaPlex Panel 2—custom mix for I/O research
- ProcartaPlex panel configurator tool—choose your specific I/O targets and have us blend and validate a custom multiplex panel for you with up to 80 analytes
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For Research Use Only. Not for use in diagnostic procedures.