Our extensive range of hit-to-lead heterocyclic building blocks are specifically designed for lead optimization through SAR development.
Key features:
- Over 300 different heterocyclic ring systems—adds to the pharmacophoric profile of your target molecules
- All synthetically useful functional groups—facilitates the full breadth of chemical synthesis techniques
- Ring regioisomers—enables systematic exploration of structural diversity space and broadens intellectual property protection
- Minimal substitution—provides easier interpretation of SAR
The table below provides examples of our systematic approach, where a tick represents the available functional groups for the ring system shown.
| Functional group ring system | |||||
|---|---|---|---|---|---|
 |  |  |  |  | |
| CO2H | |||||
| COCI | |||||
| SO2CI | |||||
| CHO | |||||
| CHOCH2Br | |||||
| NCO | |||||
| NCS | |||||
| CH2Br | |||||
| CH2OH | |||||
| Br | |||||
| I | |||||
| B{OH}2 | |||||
| CH2NH2 | |||||
| NH2 | |||||
The table above provides examples of the systematic approach taken where a tick represents our offering for that functional group for the corresponding ring system.
We routinely introduce new products into our portfolio. Discover a selection of the latest compounds now available in the Maybridge building blocks portfolio:
New compounds available in the Maybridge building blocks portfolio
(5-Trifluoromethylpyridin-3-yl) boronic acid
1-Boc-azetidine-3-carboxylic acid
1-Boc-4-(aminomethyl)-piperidine
1-Boc-azetidine-3-methanol
2-Chloropyrimidine-5-sulfonyl
3-(N-Boc)-(2-aminoethyl)-azetidine
4-Pyrimidinecarboxaldehyde
6-Bromoisoquinoline
N-Boc-piperidine-4-carbonitrile
5-(Aminomethyl)-4-methylthiazole
1,3-Benzothiazole-6-carboxaldehyde
High-Throughput Screening (HTS) and Fragment-Based Drug Discovery (FBDD)
Learn why early-phase drug discovery should not be like looking for a needle in a haystack!
Resources
Maybridge library—Download any or all of the Maybridge library structure files.
For Research Use Only. Not for use in diagnostic procedures.