Our latest research findings in drug discovery and ADME/Tox are illustrated through posters presented at conferences like SBS, AACR and others; and through peer-reviewed articles. Learn more about our workshops and virtual visits for drug discovery and development scientists or view some of our most recent scientific posters by clicking the tabs below.
| Poster Title | Authors |
|---|---|
| Cryopreserved HepaRG Cells: An Alternative In Vitro Screening Tool for Human Hepatic Drug Metabolism | Julie Price, Jonathan P. Jackson, James Lovgren, Stephen S. Ferguson |
| Developing applications for primary astrocytes to enable drug discovery | Roland Leathers, Spencer Hermanson, Lucas Chase, Connie Lebakken, and Kun Bi |
| Generation of Zero-footprint iPSCs in Xeno Free or Feeder Free with CytoTune-iPS Reprogramming Kit | Gillian Wallace, Chad MacArthur, Andrew Fontes, Jasmeet Kaur, Mohan Vemuri, and Pauline T. Lieu |
| High Quality Episomal Human iPSC derived from Cord Blood with a Zero Footprint: Applications in Serum-Free and Xeno-Free Culture | Robby Kelchtermans, Shruthi Pal, Jasmeet Kaur, MacArthur Chad, Ann Peters, Tea Soon Park, Xuan Yuan, Paul Burridge, Udaykumar Kolkundkar, Elias Zambidis, Mohan Vemuri |
| High-Throughput LanthaScreen Cellular Assays for Interrogating Post-Translational Modifications of p53 and Histone H3 | Ann MacDonald, Mark Federici, Thomas Machleidt, Spencer Hermanson, Coby Carlson and Kun Bi |
| Next Generation Cell Engineering: The Jump-In™ Cell Engineering Platform | Roland Leathers, Thomas Machleidt, David Thompson, Beth Frey, Leisha Kopp, Bonnie Hanson, David Piper, Justin Wetter |
| Monitoring Post-Translational Modifications and Protein-Protein Interactions using the Proximity Ligation Assay | Nicol Watson, Kristin G. Huwiler, Tina Settineri, Rica Bruinsma, Bryan Marks, Mark Shannon, Dave Ruff, and Barry Schweitzer |
| The Next Generation of Cell-Based Imaging Assays for Apoptosis, Autophagy and Oxidative Stress from Molecular Probes | Nicol Watson, Daniel Beacham, Michelle Yan, Scott Clarke, Bhaskar Mandavilli, Bonnie Hanson, Shih-Jung Huang, Upinder Singh, Michael Janes and Nicholas Dolman |
| Novel live alkaline phosphatase substrate for identification of pluripotent stem cells | Joanne Hulme, Rene H. Quintanilla, Upinder Singh, Scott Grecian, Kyle Gee, Mahendra Rao, Uma Lakshmipathy |
| Poster Title | Authors |
|---|---|
| Functional Genomics Screening with Invitrogen LentiArray CRISPR Libraries and CellSensor Assays | Chetana Revankar, Justin Wetter, Julia Braun, Natasha Roark, Veronica Magnon, LaiYee Wong, Yanfei Zou, Namritha Ravinder, Jian-Ping Yang, Jonathan Chesnut, David Piper |
| Tools for Profiling Inhibitors for Full-Length LRRK2 | Justin Wetter, Kara Machledit, Ryan Fisher, Robert Horton, David Piper |
| Cellular and Biochemical Assay Applications on the Varioskan LUX Multimode Microplate Reader | Chetana Revankar , Justin Wetter, Jacquelyn Webb, Kyle Kimler, Robert Horton, David Piper |
| High Content Solutions: Functionality of Primary Hepatocytes and Adaptability to High-Content Screening for In Vitro ADME/Tox Applications | Raquel Vega, Rafal Witek, and David Piper |
| Poster Title | Authors |
|---|---|
| High-throughput LanthaScreen cellular assays for interrogating post-translational modifications of p53 and histone H3 | Mark Federici, Thomas Machleidt, Spencer Hermanson, Coby Carlson and Kun Bi |
| Next-generation cell-based imaging assays for apoptosis and oxidative stress from Molecular Probes | Daniel Beacham, Michelle Yan, Scott Clarke, Bhaskar Mandavilli, Bonnie Hanson, Shih-Jung Huang, Upinder Singh, Michael Janes and Nicholas Dolman |
| NA-Fluor and NA-XTD influenza neuraminidase assays for neuraminidase quantitation and inhibition assays | Anthony C. Chiulli, Corinne E. Miller, Albana Mihali, Laura Thibodeau, Rouh-Rong Juo, Brian D’Eon, and Melissa A. Gee |
| Endogenous GPCR transcript profiling of Life Technologies primary cell offerings: Opening the door to physiologically relevant cell systems for pharmaceutical screens | Rhonda A. Newman & David T. Kuninger |
| Primary human cells from Life Technologies—offerings, scale, and applications in HCS and HTS formats | David Kuninger, Nick Dolman, Kevin Chambers, Coby Carlson and Daniel Beacham |
| Next-generation chemiluminescent secreted placental alkaline phosphatase (SEAP) reporter gene assay | Corinne E. Miller, Laura Thibodeau, and Brian J. D’Eon |
| Expression, capture and display of native GPCRs on soluble mammalian membrane particles | Sanjay Vasu, Wen Chen, Julia Fletcher, Kristin Huwiler, Wieslaw Kudlicki, Kevin Lowitz |
| The PrestoBlue Cell Viability Reagent: Measure cell viability in a fraction of the time | Bonnie J. Hanson, Michael Hancock, Leisha Kopp, Uma Lakshmipathy |
| A substrate-independent histone deacetylase inhibitor assay | Steve Riddle, Steve Fakhoury, Bryan Marks, Hildegard Eliason and Jack Frazee |
| Simply sensitive: Phosphate detection made easy | Kevin R. Kupcho, Caroline M. Wessely, Steve M. Riddle, and Kevin L. Vedvik |
| Monitoring post-translational modifications and protein-protein interactions using a proximity ligation assay | Kristin G. Huwiler, Tina Settineri, Rica Bruinsma, Bryan Marks, Mark Shannon, Dave Ruff, & Barry Schweitzer |
| A flexible kinase inhibitor assay platform for active, non-activated, and impure kinase preparations | Caroline Wessely, Connie Lebakken, Laurie Reichling, Jason Ellefson, Kun Bi and Steve Riddle |
| Poster Title | Authors |
|---|---|
| Cryopreserved HepaRG Cells: An Alternative In Vitro Screening Tool for Human Hepatic Drug Metabolism | Julie Price, Jonathan P. Jackson, James Lovgren, Stephen S. Ferguson |
| Developing applications for primary astrocytes to enable drug discovery | Roland Leathers, Spencer Hermanson, Lucas Chase, Connie Lebakken, and Kun Bi |
| Generation of Zero-footprint iPSCs in Xeno Free or Feeder Free with CytoTune-iPS Reprogramming Kit | Gillian Wallace, Chad MacArthur, Andrew Fontes, Jasmeet Kaur, Mohan Vemuri, and Pauline T. Lieu |
| High Quality Episomal Human iPSC derived from Cord Blood with a Zero Footprint: Applications in Serum-Free and Xeno-Free Culture | Robby Kelchtermans, Shruthi Pal, Jasmeet Kaur, MacArthur Chad, Ann Peters, Tea Soon Park, Xuan Yuan, Paul Burridge, Udaykumar Kolkundkar, Elias Zambidis, Mohan Vemuri |
| High-Throughput LanthaScreen Cellular Assays for Interrogating Post-Translational Modifications of p53 and Histone H3 | Ann MacDonald, Mark Federici, Thomas Machleidt, Spencer Hermanson, Coby Carlson and Kun Bi |
| Next Generation Cell Engineering: The Jump-In™ Cell Engineering Platform | Roland Leathers, Thomas Machleidt, David Thompson, Beth Frey, Leisha Kopp, Bonnie Hanson, David Piper, Justin Wetter |
| Monitoring Post-Translational Modifications and Protein-Protein Interactions using the Proximity Ligation Assay | Nicol Watson, Kristin G. Huwiler, Tina Settineri, Rica Bruinsma, Bryan Marks, Mark Shannon, Dave Ruff, and Barry Schweitzer |
| The Next Generation of Cell-Based Imaging Assays for Apoptosis, Autophagy and Oxidative Stress from Molecular Probes | Nicol Watson, Daniel Beacham, Michelle Yan, Scott Clarke, Bhaskar Mandavilli, Bonnie Hanson, Shih-Jung Huang, Upinder Singh, Michael Janes and Nicholas Dolman |
| Novel live alkaline phosphatase substrate for identification of pluripotent stem cells | Joanne Hulme, Rene H. Quintanilla, Upinder Singh, Scott Grecian, Kyle Gee, Mahendra Rao, Uma Lakshmipathy |
| Poster Title | Authors |
|---|---|
| Functional Genomics Screening with Invitrogen LentiArray CRISPR Libraries and CellSensor Assays | Chetana Revankar, Justin Wetter, Julia Braun, Natasha Roark, Veronica Magnon, LaiYee Wong, Yanfei Zou, Namritha Ravinder, Jian-Ping Yang, Jonathan Chesnut, David Piper |
| Tools for Profiling Inhibitors for Full-Length LRRK2 | Justin Wetter, Kara Machledit, Ryan Fisher, Robert Horton, David Piper |
| Cellular and Biochemical Assay Applications on the Varioskan LUX Multimode Microplate Reader | Chetana Revankar , Justin Wetter, Jacquelyn Webb, Kyle Kimler, Robert Horton, David Piper |
| High Content Solutions: Functionality of Primary Hepatocytes and Adaptability to High-Content Screening for In Vitro ADME/Tox Applications | Raquel Vega, Rafal Witek, and David Piper |
| Poster Title | Authors |
|---|---|
| High-throughput LanthaScreen cellular assays for interrogating post-translational modifications of p53 and histone H3 | Mark Federici, Thomas Machleidt, Spencer Hermanson, Coby Carlson and Kun Bi |
| Next-generation cell-based imaging assays for apoptosis and oxidative stress from Molecular Probes | Daniel Beacham, Michelle Yan, Scott Clarke, Bhaskar Mandavilli, Bonnie Hanson, Shih-Jung Huang, Upinder Singh, Michael Janes and Nicholas Dolman |
| NA-Fluor and NA-XTD influenza neuraminidase assays for neuraminidase quantitation and inhibition assays | Anthony C. Chiulli, Corinne E. Miller, Albana Mihali, Laura Thibodeau, Rouh-Rong Juo, Brian D’Eon, and Melissa A. Gee |
| Endogenous GPCR transcript profiling of Life Technologies primary cell offerings: Opening the door to physiologically relevant cell systems for pharmaceutical screens | Rhonda A. Newman & David T. Kuninger |
| Primary human cells from Life Technologies—offerings, scale, and applications in HCS and HTS formats | David Kuninger, Nick Dolman, Kevin Chambers, Coby Carlson and Daniel Beacham |
| Next-generation chemiluminescent secreted placental alkaline phosphatase (SEAP) reporter gene assay | Corinne E. Miller, Laura Thibodeau, and Brian J. D’Eon |
| Expression, capture and display of native GPCRs on soluble mammalian membrane particles | Sanjay Vasu, Wen Chen, Julia Fletcher, Kristin Huwiler, Wieslaw Kudlicki, Kevin Lowitz |
| The PrestoBlue Cell Viability Reagent: Measure cell viability in a fraction of the time | Bonnie J. Hanson, Michael Hancock, Leisha Kopp, Uma Lakshmipathy |
| A substrate-independent histone deacetylase inhibitor assay | Steve Riddle, Steve Fakhoury, Bryan Marks, Hildegard Eliason and Jack Frazee |
| Simply sensitive: Phosphate detection made easy | Kevin R. Kupcho, Caroline M. Wessely, Steve M. Riddle, and Kevin L. Vedvik |
| Monitoring post-translational modifications and protein-protein interactions using a proximity ligation assay | Kristin G. Huwiler, Tina Settineri, Rica Bruinsma, Bryan Marks, Mark Shannon, Dave Ruff, & Barry Schweitzer |
| A flexible kinase inhibitor assay platform for active, non-activated, and impure kinase preparations | Caroline Wessely, Connie Lebakken, Laurie Reichling, Jason Ellefson, Kun Bi and Steve Riddle |
For Research Use Only. Not for use in diagnostic procedures.