AKT Signaling Pathway
AKT is a serine/threonine kinase that is involved in mediating various biological responses, such as inhibition of apoptosis.
Browse adaptive immunity pathways
Adaptive immunity is one of two ways by which vertebrates clear pathogens from the body. The adaptive immune system provides long-term protection against specific pathogens. A variety of cell signaling pathways are involved in this area of biology, including the AKT signaling pathway, the Fas signaling pathway, and the RANK pathway.
Antigen Processing and Presentation by MHCs
Antigen processing and presentation are the processes that result in association of proteins with major histocompatibility complex (MHC) molecules for recognition by a T-cell.
APRIL Pathway
In immune responses, APRIL acts as a co-stimulator for B-cell and T-cell proliferation and supports class switch.
B-Cell Development Pathway
In immune responses, APRIL acts as a co-stimulator for B-cell and T-cell proliferation and supports class switch.
B-Cell Receptor Complex
The B-cell receptor (BCR) complex usually consists of an antigen-binding subunit that is composed of two Ig heavy chains, two Ig light chains, and a signaling subunit.
CD4 and CD8 T-Cell Lineage
Each mature T-cell generally retains expression of the co-receptor molecule (CD4 or CD8) that has a major histocompatibility complex (MHC)-binding property that matches that of its T-cell receptor (TCR).
CTLA4 Signaling Pathway
The co-stimulatory CTLA4 pathway attenuates or down-regulates T-cell activation. CTLA4 is designed to remove body cells displaying a foreign epitope.
Fas Signaling
FAS (also called APO1 or CD95) is a death domain–containing member of the tumor necrosis factor (TNF) receptor superfamily.
Granzyme Pathway
Granzyme A (GzmA) activates a caspase-independent cell death pathway with morphological features of apoptosis.
ICos-ICosL Pathway in T-Helper Cells
IL-2 is a cytokine that stimulates the growth, proliferation, and differentiation of T-cells, B-cells, NK cells, and other immune cells.
IL-2 Gene Expression in Activated and Quiescent T-Cells
IL-2 is a cytokine that stimulates the growth, proliferation, and differentiation of T-cells, B-cells, NK cells, and other immune cells.
IL-6 Pathway
IL-6 is a pleiotropic cytokine that affects the immune system and many physiological events in various organs.
IL-10 Pathway
IL-10 is a pleiotropic cytokine with important immunoregulatory functions and whose activities influence many immune cell types.
Interferon Pathway
Interferons are pleiotropic cytokines best known for their ability to induce cellular resistance to viral infection.
JAK/STAT Pathway
The JAK/STAT pathway is a signaling cascade whose evolutionarily conserved roles include cell proliferation and hematopoiesis.
MAPK Family Pathway
Mitogen-activated protein kinases (MAPKs) belong to a large family of serine/threonine protein kinases that are conserved in organisms as diverse as yeast and humans.
PI3K Signaling in B Lymphocytes
The phosphoinositide 3-kinases (PI3Ks) regulate numerous biological processes, including cell growth, differentiation, survival, proliferation, migration, and metabolism.
RANK Pathway
RANKL and its receptor RANK are key regulators of bone remodeling, and are essential for the development and activation of osteoclasts.
TGF-Beta Pathway
Members of the transforming growth factor (TGF)-beta family play an important role in the development, homeostasis, and repair of most tissues.
THC Differentiation Pathway
T-helper cells of type 1 (TH1) and type 2 (TH2) are derived from T-helper cells and provide help to cells of both the innate and adaptive immune systems.
TNF Superfamily Pathway
The tumor necrosis factor (TNF) superfamily consists of 19 members that signal through 29 receptors that are members of the TNF receptor (TNFR) superfamily.
Tumoricidal Effects of Hepatic NK Cells
The liver is a major site for the formation and metastasis of tumors.
Antibodies Resource Library
Access a targeted collection of scientific application notes, methods, and cell signaling charts.
For Research Use Only. Not for use in diagnostic procedures.