Cancer Immunoediting
The immune system attempts to constrain tumor growth, but sometimes tumor cells might escape or attenuate this immune pressure.
Browse cancer biology pathways
Cancer is a type of disease resulting from abnormal cell growth that has the possibility of metastasizing, or spreading to other parts of the body. Environmental toxins and genetic mutations can play a role in the development of tumors. Some of the most important pathways involved in cancer biology are the ErbB family pathway, the p53-mediated apoptosis pathway, and the GSK3 signaling pathway.
ErbB Family Pathway
The ErbB family of transmembrane receptor tyrosine kinases (RTKs) plays an important role during the growth and development of organs.
GSK3 Signaling Pathway
GSK3 is a ubiquitously expressed, highly conserved serine/threonine protein kinase found in all eukaryotes.
p53-Mediated Apoptosis Pathway
Tumor protein p53 is a nuclear transcription factor that regulates the expression of a wide variety of genes involved in apoptosis, growth arrest, or senescence in response to genotoxic or cellular stress.
TGF-Beta Pathway
Members of the transforming growth factor (TGF)-beta family play an important role in the development, homeostasis, and repair of most tissues.
Tumoricidal Effects of Hepatic NK Cells
The liver is a major site for the formation and metastasis of tumors.
Antibodies Resource Library
Access a targeted collection of scientific application notes, methods, and cell signaling charts.
For Research Use Only. Not for use in diagnostic procedures.