Product References
Vγ1 and Vγ4 gamma-delta T cells play opposing roles in the immunopathology of traumatic brain injury in males.
Nature communications
Abou-El-Hassan H,Rezende RM,Izzy S,Gabriely G,Yahya T,Tatematsu BK,Habashy KJ,Lopes JR,de Oliveira GLV,Maghzi AH,Yin Z,Cox LM,Krishnan R,Butovsky O,Weiner HL
17-5711-82 was used in Flow cytometry/Cell sorting to provide new insights on the role of different γδ T cell subsets after brain injury and lay down the principles for the development of targeted γδ T-cell-based therapy for TBI.
Tue Jul 18 00:00:00 EDT 2023
A nonredundant role for T cell-derived interleukin 22 in antibacterial defense of colonic crypts.
Immunity
Zindl CL,Witte SJ,Laufer VA,Gao M,Yue Z,Janowski KM,Cai B,Frey BF,Silberger DJ,Harbour SN,Singer JR,Turner H,Lund FE,Vallance BA,Rosenberg AF,Schoeb TR,Chen JY,Hatton RD,Weaver CT
17-5711-82 was used in Flow cytometry/Cell sorting to demonstrate spatiotemporal differences in the production and action of IL-22 by ILCs and T cells during infection and reveal an indispensable role for IL-22-producing T cells in the protection of the intestinal crypts.
Tue Mar 08 00:00:00 EST 2022
Nt5e deficiency does not affect post-stroke inflammation and lesion size in a murine ischemia/reperfusion stroke model.
iScience
Schädlich IS,Schnapauff O,Pöls L,Schrader J,Tolosa E,Rissiek B,Magnus T
17-5711-82 was used in Flow cytometry/Cell sorting to highlight the potential impact of stroke models on study outcome and the need for cross-validation of originally promising immunomodulatory candidates.
Fri Jun 17 00:00:00 EDT 2022
Nociceptive sensory neurons promote CD8 T cell responses to HSV-1 infection.
Nature communications
Filtjens J,Roger A,Quatrini L,Wieduwild E,Gouilly J,Hoeffel G,Rossignol R,Daher C,Debroas G,Henri S,Jones CM,Malissen B,Mackay LK,Moqrich A,Carbone FR,Ugolini S
Published figure using TCR gamma/delta monoclonal antibody (Product # 17-5711-82) in Flow Cytometry
Tue May 18 00:00:00 EDT 2021
Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease.
Cell
Lee JY,Hall JA,Kroehling L,Wu L,Najar T,Nguyen HH,Lin WY,Yeung ST,Silva HM,Li D,Hine A,Loke P,Hudesman D,Martin JC,Kenigsberg E,Merad M,Khanna KM,Littman DR
17-5711 was used in Flow cytometry/Cell sorting to suggest that serum amyloid A proteins direct a pathogenic pro-inflammatory Th17 cell differentiation program and promote Th17-mediated inflammatory diseases.
Thu Jan 09 00:00:00 EST 2020
The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis.
The Journal of clinical investigation
Müller A,Dickmanns A,Resch C,Schäkel K,Hailfinger S,Dobbelstein M,Schulze-Osthoff K,Kramer D
17-5711 was used in Flow cytometry/Cell sorting to find a hyperactivation of the CDK4/6-EZH2 pathway in human and mouse psoriatic skin lesions.
Mon Nov 02 00:00:00 EST 2020
MALT1 targeting suppresses CARD14-induced psoriatic dermatitis in mice.
EMBO reports
Van Nuffel E,Staal J,Baudelet G,Haegman M,Driege Y,Hochepied T,Afonina IS,Beyaert R
17-5711-82 was used in Flow Cytometry to investigate if inducible keratinocyte-specific expression of CARD14E138A in mice rapidly induces epidermal thickening and inflammation as well as increased expression of several genes associated with psoriasis in humans.
Fri Jul 03 00:00:00 EDT 2020
Identification of atypical mitogen-activated protein kinase MAPK4 as a novel regulator in acute lung injury.
Cell & bioscience
Mao L,Zhou Y,Chen L,Hu L,Liu S,Zheng W,Zhao J,Guo M,Chen C,He Z,Xu L
17-5711-82 was used in Flow Cytometry to reveal an unknown role of atypical MAPKs member MAPK4 in the pathology of acute lung injury.
Sun Apr 17 00:00:00 EDT 2022
Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity.
Nature communications
Toubal A,Kiaf B,Beaudoin L,Cagninacci L,Rhimi M,Fruchet B,da Silva J,Corbett AJ,Simoni Y,Lantz O,Rossjohn J,McCluskey J,Lesnik P,Maguin E,Lehuen A
17-5711 was used in Flow cytometry/Cell sorting to show that during obesity MAIT cells promote inflammation in both adipose tissue and ileum, leading to insulin resistance and impaired glucose and lipid metabolism.
Fri Jul 24 00:00:00 EDT 2020
Metabolite-Sensing Receptor Ffar2 Regulates Colonic Group 3 Innate Lymphoid Cells and Gut Immunity.
Immunity
Chun E,Lavoie S,Fonseca-Pereira D,Bae S,Michaud M,Hoveyda HR,Fraser GL,Gallini Comeau CA,Glickman JN,Fuller MH,Layden BT,Garrett WS
17-5711 was used in Flow cytometry/Cell sorting to demonstrate group 3 innate lymphoid cells are regulated by the metabolite-sensing receptor Ffar2.
Tue Nov 19 00:00:00 EST 2019
Cell-Type-Specific Responses to Interleukin-1 Control Microbial Invasion and Tumor-Elicited Inflammation in Colorectal Cancer.
Immunity
Dmitrieva-Posocco O,Dzutsev A,Posocco DF,Hou V,Yuan W,Thovarai V,Mufazalov IA,Gunzer M,Shilovskiy IP,Khaitov MR,Trinchieri G,Waisman A,Grivennikov SI
17-5711-82 was used in Flow Cytometry to examine the impact of IL-1 signaling, a key regulator of the IL-17 pathway, in different cell types within the CRC microenvironment.
Tue Jan 15 00:00:00 EST 2019
Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence.
Molecular cell
Zhang H,Alsaleh G,Feltham J,Sun Y,Napolitano G,Riffelmacher T,Charles P,Frau L,Hublitz P,Yu Z,Mohammed S,Ballabio A,Balabanov S,Mellor J,Simon AK
17-5711 was used in Flow cytometry/Cell sorting to reveal an unexpected autophagy regulatory mechanism mediated by eIF5A at the translational level, which can be harnessed to reverse immune senescence in humans.
Thu Oct 03 00:00:00 EDT 2019
NKp46-expressing human gut-resident intraepithelial Vδ1 T cell subpopulation exhibits high antitumor activity against colorectal cancer.
JCI insight
Mikulak J,Oriolo F,Bruni E,Roberto A,Colombo FS,Villa A,Bosticardo M,Bortolomai I,Lo Presti E,Meraviglia S,Dieli F,Vetrano S,Danese S,Della Bella S,Carvello MM,Sacchi M,Cugini G,Colombo G,Klinger M,Spaggiari P,Roncalli M,Prinz I,Ravens S,di Lorenzo B,Marcenaro E,Silva-Santos B,Spinelli A,Mavilio D
17-5711-82 was used in Flow Cytometry to parallel the very low frequencies of NKp46+/Vδ1 IELs able to infiltrate CRC, thus providing insights to either follow-up cancer progression or to develop adoptive cellular therapies.
Thu Dec 19 00:00:00 EST 2019
Gain-of-Function Mutation of Card14 Leads to Spontaneous Psoriasis-like Skin Inflammation through Enhanced Keratinocyte Response to IL-17A.
Immunity
Wang M,Zhang S,Zheng G,Huang J,Songyang Z,Zhao X,Lin X
17-5711 was used in Flow cytometry/Cell sorting to show CARMA2 serves as a key mediator of IL-17A signaling and its constitutive activation in keratinocytes leads to the onset of psoriasis.
Tue Jul 17 00:00:00 EDT 2018
The Environmental Sensor AHR Protects from Inflammatory Damage by Maintaining Intestinal Stem Cell Homeostasis and Barrier Integrity.
Immunity
Metidji A,Omenetti S,Crotta S,Li Y,Nye E,Ross E,Li V,Maradana MR,Schiering C,Stockinger B
17-5711 was used in Flow cytometry/Cell sorting to study the role of the aryl hydrocarbon receptor pathway of intestinal epithelial cells in maintaining intestinal barrier integrity.
Tue Aug 21 00:00:00 EDT 2018
Co-inhibitory Molecule B7 Superfamily Member 1 Expressed by Tumor-Infiltrating Myeloid Cells Induces Dysfunction of Anti-tumor CD8+ T Cells.
Immunity
Li J,Lee Y,Li Y,Jiang Y,Lu H,Zang W,Zhao X,Liu L,Chen Y,Tan H,Yang Z,Zhang MQ,Mak TW,Ni L,Dong C
17-5711 was used in Flow cytometry/Cell sorting to demonstrate that increased B7S1 expression in myeloid cells from human hepatocellular carcinoma is correlated with CD8+ T cell dysfunction.
Tue Apr 17 00:00:00 EDT 2018
Protective role of γδ T cells in cigarette smoke and influenza infection.
Mucosal immunology
Hong MJ,Gu BH,Madison MC,Landers C,Tung HY,Kim M,Yuan X,You R,Machado AA,Gilbert BE,Soroosh P,Elloso M,Song L,Chen M,Corry DB,Diehl G,Kheradmand F
Published figure using TCR gamma/delta monoclonal antibody (Product # 17-5711-82) in Flow Cytometry
Tue May 01 00:00:00 EDT 2018
A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment.
eLife
Ng KK,Yui MA,Mehta A,Siu S,Irwin B,Pease S,Hirose S,Elowitz MB,Rothenberg EV,Kueh HY
17-5711 was used in Flow cytometry/Cell sorting to study the activation of Bcl11b, which controls T-cell fate commitment.
Tue Nov 20 00:00:00 EST 2018
γδ T cells control humoral immune response by inducing T follicular helper cell differentiation.
Nature communications
Rezende RM,Lanser AJ,Rubino S,Kuhn C,Skillin N,Moreira TG,Liu S,Gabriely G,David BA,Menezes GB,Weiner HL
17-5711 was used in Flow cytometry/Cell sorting to demonstrate that complete Freund's adjuvant immunisation induces a subpopulation of CXCR5-expressing γδ T cells in the draining lymph nodes.
Wed Aug 08 00:00:00 EDT 2018
ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control.
The Journal of experimental medicine
Schwartz C,Khan AR,Floudas A,Saunders SP,Hams E,Rodewald HR,McKenzie ANJ,Fallon PG
17-5711 was used in Flow cytometry/Cell sorting to study how group 2 innate lymphoid cells regulate adaptive Th2 cell functions.
Mon Sep 04 00:00:00 EDT 2017
MyD88 signaling in dendritic cells and the intestinal epithelium controls immunity against intestinal infection with C. rodentium.
PLoS pathogens
Friedrich C,Mamareli P,Thiemann S,Kruse F,Wang Z,Holzmann B,Strowig T,Sparwasser T,Lochner M
17-5711 was used in Flow cytometry/Cell sorting to suggest that MyD88 signaling in DC and IEC is both essential and sufficient to induce a full spectrum of host responses upon intestinal infection with C. rodentium.
Mon May 01 00:00:00 EDT 2017
Retinoic Acid Regulates Immune Responses by Promoting IL-22 and Modulating S100 Proteins in Viral Hepatitis.
Journal of immunology (Baltimore, Md. : 1950)
Jie Z,Liang Y,Yi P,Tang H,Soong L,Cong Y,Zhang K,Sun J
17-5711 was used in Flow cytometry/Cell sorting to determine the role of retinoic acid in IL-22 production during hepatitis infection.
Mon May 01 00:00:00 EDT 2017
Expression and Function of Granzymes A and B in Escherichia coli Peritonitis and Sepsis.
Mediators of inflammation
García-Laorden MI,Stroo I,Terpstra S,Florquin S,Medema JP,van T Veer C,de Vos AF,van der Poll T
17-5711 was used in Flow cytometry/Cell sorting to investigate the role of gzms in the host response to E. coli-induced peritonitis and sepsis in vivo.
Mon Apr 30 00:00:00 EDT 2018
A tightly regulated IL-22 response maintains immune functions and homeostasis in systemic viral infection.
Scientific reports
Yi P,Liang Y,Yuan DMK,Jie Z,Kwota Z,Chen Y,Cong Y,Fan X,Sun J
Tue Jun 20 00:00:00 EDT 2017
MicroRNA-7 Deficiency Ameliorates the Pathologies of Acute Lung Injury through Elevating KLF4.
Frontiers in immunology
Zhao J,Chen C,Guo M,Tao Y,Cui P,Zhou Y,Qin N,Zheng J,Zhang J,Xu L
17-5711 was used in Flow cytometry/Cell sorting to study the role of microRNA-7 in acute lung injury, allowing the development of new therapeutic strategies against inflammatory lung disease.
Wed Mar 16 00:00:00 EDT 2022
Balancing intestinal and systemic inflammation through cell type-specific expression of the aryl hydrocarbon receptor repressor.
Scientific reports
Brandstätter O,Schanz O,Vorac J,König J,Mori T,Maruyama T,Korkowski M,Haarmann-Stemmann T,von Smolinski D,Schultze JL,Abel J,Esser C,Takeyama H,Weighardt H,Förster I
17-5711 was used in Flow cytometry/Cell sorting to highlight the physiologic importance of cell-type specific balancing of AhR/AhRR expression in response to microbial, nutritional and other environmental stimuli.
Tue May 17 00:00:00 EDT 2016
Premature thymic involution is independent of structural plasticity of the thymic stroma.
European journal of immunology
Franckaert D,Schlenner SM,Heirman N,Gill J,Skogberg G,Ekwall O,Put K,Linterman MA,Dooley J,Liston A
17-5711 was used in Flow cytometry/Cell sorting to investigate thymic involution in FVB/N mice, showing that disruption of the epithelial-endothelial relationship and a progressive loss of pro-T cells precedes involution, and loss of pro-T cells is sufficient to drive premature involution, suggesting that pro-T cells are the main driver of involution.
Fri May 01 00:00:00 EDT 2015
Intestinal microbiota modulates gluten-induced immunopathology in humanized mice.
The American journal of pathology
Galipeau HJ,McCarville JL,Huebener S,Litwin O,Meisel M,Jabri B,Sanz Y,Murray JA,Jordana M,Alaedini A,Chirdo FG,Verdu EF
17-5711 was used in Flow cytometry/Cell sorting to assess whether specific microbiota compositions influence immune responses to gluten in mice expressing the human DQ8 gene, which confers moderate CD genetic susceptibility.
Sun Nov 01 00:00:00 EDT 2015
A genome-wide analysis identifies a notch-RBP-Jκ-IL-7Rα axis that controls IL-17-producing γδ T cell homeostasis in mice.
Journal of immunology (Baltimore, Md. : 1950)
Nakamura M,Shibata K,Hatano S,Sato T,Ohkawa Y,Yamada H,Ikuta K,Yoshikai Y
17-5711 was used in Flow cytometry/Cell sorting to investigate additional roles for the Notch axis in the homeostasis of γδ T cells.
Thu Jan 01 00:00:00 EST 2015
IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2(+)Vγ6(+)γδ T cells.
Nature communications
Akitsu A,Ishigame H,Kakuta S,Chung SH,Ikeda S,Shimizu K,Kubo S,Liu Y,Umemura M,Matsuzaki G,Yoshikai Y,Saijo S,Iwakura Y
Published figure using TCR gamma/delta monoclonal antibody (Product # 17-5711-82) in Flow Cytometry
Thu Jun 25 00:00:00 EDT 2015
Microbiota modulate tumoral immune surveillance in lung through a γδT17 immune cell-dependent mechanism.
Cancer research
Cheng M,Qian L,Shen G,Bian G,Xu T,Xu W,Shen G,Hu S
17-5711 was used in Flow cytometry/Cell sorting to investigate the mechanism by which commensal bacteria modulate the efficiency of tumoral immune surveillance in mucosal tissues.
Fri Aug 01 00:00:00 EDT 2014
Intrahepatic innate lymphoid cells secrete IL-17A and IL-17F that are crucial for T cell priming in viral infection.
Journal of immunology (Baltimore, Md. : 1950)
Jie Z,Liang Y,Hou L,Dong C,Iwakura Y,Soong L,Cong Y,Sun J
17-5711 was used in Flow cytometry/Cell sorting to investigate the source and regulation of the IL-17 surge in the liver microenvironment that occurs early in the response to viral infection.
Tue Apr 01 00:00:00 EDT 2014
γδ T cells recognize the insulin B:9-23 peptide antigen when it is dimerized through thiol oxidation.
Molecular immunology
Aydintug MK,Zhang L,Wang C,Liang D,Wands JM,Michels AW,Hirsch B,Day BJ,Zhang G,Sun D,Eisenbarth GS,O'Brien RL,Born WK
17-5711 was used in Flow cytometry/Cell sorting to determine why γδ T cells require a secondary amino acid recognition site on the insulin peptide, B:9-23.
Fri Aug 01 00:00:00 EDT 2014
γδT cells are prevalent in the proximal aorta and drive nascent atherosclerotic lesion progression and neutrophilia in hypercholesterolemic mice.
PloS one
Vu DM,Tai A,Tatro JB,Karas RH,Huber BT,Beasley D
17-5711 was used in Flow cytometry/Cell sorting to reveal a pathogenic role of γδT cells in early atherogenesis in ApoE KO mice, by mechanisms likely to involve their IL-17 production and induction of neutrophilia.
Tue Jun 16 00:00:00 EDT 2015
Alteration of the thymic T cell repertoire by rotavirus infection is associated with delayed type 1 diabetes development in non-obese diabetic mice.
PloS one
Webster NL,Zufferey C,Pane JA,Coulson BS
17-5711 was used in Flow cytometry/Cell sorting to demonstrate the consequences of rotaviral infection for the immune system and the appearance of the symptoms of diabetes.
Tue Sep 24 00:00:00 EDT 2013
γδ T cells recognize a microbial encoded B cell antigen to initiate a rapid antigen-specific interleukin-17 response.
Immunity
Zeng X,Wei YL,Huang J,Newell EW,Yu H,Kidd BA,Kuhns MS,Waters RW,Davis MM,Weaver CT,Chien YH
17-5711 was used in Flow cytometry/Cell sorting to study the γδ T cell response to the algae protein, phycoerythrin.
Fri Sep 21 00:00:00 EDT 2012
Transcription factor RORα is critical for nuocyte development.
Nature immunology
Wong SH,Walker JA,Jolin HE,Drynan LF,Hams E,Camelo A,Barlow JL,Neill DR,Panova V,Koch U,Radtke F,Hardman CS,Hwang YY,Fallon PG,McKenzie AN
17-5711 was used in Flow cytometry/Cell sorting to study how nuocytes arose in the bone marrow and differentiated from common lymphoid progenitors, indicating they are a distinct, previously unknown member of the lymphoid lineage.
Sun Jan 22 00:00:00 EST 2012
Vaccination with immunotherapeutic Listeria monocytogenes induces IL-17(+) γδ T cells in a murine model for HPV associated cancer.
Oncoimmunology
Guirnalda PD,Paterson Y
17-5711 was used in Flow cytometry/Cell sorting to investigate the role of IL-17 in Listeria based immunotherapy.
Sat Sep 01 00:00:00 EDT 2012
PreTCR and TCRγδ signal initiation in thymocyte progenitors does not require domains implicated in receptor oligomerization.
Science signaling
Mahtani-Patching J,Neves JF,Pang DJ,Stoenchev KV,Aguirre-Blanco AM,Silva-Santos B,Pennington DJ
17-5711 was used in Flow cytometry/Cell sorting to demonstrate that signal initiation by preTCR and TCRγδ during thymocyte development does not require regions of the extracellular domains that were implicated in receptor oligomerisation.
Tue Jul 19 00:00:00 EDT 2011
Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells.
Journal of immunology (Baltimore, Md. : 1950)
Jones GW,McLoughlin RM,Hammond VJ,Parker CR,Williams JD,Malhotra R,Scheller J,Williams AS,Rose-John S,Topley N,Jones SA
17-5711 was used in Flow cytometry/Cell sorting to report that local control of IL-6 trans signalling regulates the effector characteristics of the T cell infiltrate and promotes the maintenance of IL-17A-secreting CD4(+) T cells.
Mon Feb 15 00:00:00 EST 2010
Expression of the chemokine binding protein M3 promotes marked changes in the accumulation of specific leukocytes subsets within the intestine.
Gastroenterology
Shang L,Thirunarayanan N,Viejo-Borbolla A,Martin AP,Bogunovic M,Marchesi F,Unkeless JC,Ho Y,Furtado GC,Alcami A,Merad M,Mayer L,Lira SA
Published figure using TCR gamma/delta monoclonal antibody (Product # 17-5711-82) in Flow Cytometry
Tue Sep 01 00:00:00 EDT 2009
