Product References
Stem cell architecture drives myelodysplastic syndrome progression and predicts response to venetoclax-based therapy.
Nature medicine
Ganan-Gomez I,Yang H,Ma F,Montalban-Bravo G,Thongon N,Marchica V,Richard-Carpentier G,Chien K,Manyam G,Wang F,Alfonso A,Chen S,Class C,Kanagal-Shamanna R,Ingram JP,Ogoti Y,Rose A,Loghavi S,Lockyer P,Cambo B,Muftuoglu M,Schneider S,Adema V,McLellan M,Garza J,Marchesini M,Giuliani N,Pellegrini M,Wang J,Walker J,Li Z,Takahashi K,Leverson JD,Bueso-Ramos C,Andreeff M,Clise-Dwyer K,Garcia-Manero G,Colla S
11-0453-82 was used in Flow Cytometry to study the biological mechanisms that drive hypomethylating agent therapy failure at the stem-cell level to uncover vulnerabilities in the disease and halt its evolution.
Tue Mar 01 00:00:00 EST 2022
Tet-mediated DNA demethylation regulates specification of hematopoietic stem and progenitor cells during mammalian embryogenesis.
Science advances
Ma L,Tang Q,Gao X,Lee J,Lei R,Suzuki M,Zheng D,Ito K,Frenette PS,Dawlaty MM
Published figure using CD45.1 monoclonal antibody (Product # 11-0453-82) in Flow Cytometry
Fri Mar 04 00:00:00 EST 2022
Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation.
Nature immunology
Rivas MA,Meydan C,Chin CR,Challman MF,Kim D,Bhinder B,Kloetgen A,Viny AD,Teater MR,McNally DR,Doane AS,Béguelin W,Fernández MTC,Shen H,Wang X,Levine RL,Chen Z,Tsirigos A,Elemento O,Mason CE,Melnick AM
Published figure using CD45.1 monoclonal antibody (Product # 11-0453-82) in Flow Cytometry
Mon Feb 01 00:00:00 EST 2021
Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions.
The Journal of experimental medicine
Ho TT,Dellorusso PV,Verovskaya EV,Bakker ST,Flach J,Smith LK,Ventura PB,Lansinger OM,Hérault A,Zhang SY,Kang YA,Mitchell CA,Villeda SA,Passegué E
Published figure using CD45.1 monoclonal antibody (Product # 11-0453-82) in Flow Cytometry
Mon Jul 05 00:00:00 EDT 2021
Differentiation of fetal hematopoietic stem cells requires ARID4B to restrict autocrine KITLG/KIT-Src signaling.
Cell reports
Young IC,Wu B,Andricovich J,Chuang ST,Li R,Tzatsos A,Wu RC,Wu MY
Published figure using CD45.1 monoclonal antibody (Product # 11-0453-82) in Flow Cytometry
Tue Nov 23 00:00:00 EST 2021
Development of a VRC01-class germline targeting immunogen derived from anti-idiotypic antibodies.
Cell reports
Seydoux E,Wan YH,Feng J,Wall A,Aljedani S,Homad LJ,MacCamy AJ,Weidle C,Gray MD,Brumage L,Taylor JJ,Pancera M,Stamatatos L,McGuire AT
Published figure using CD45.1 monoclonal antibody (Product # 11-0453-82) in Flow Cytometry
Tue May 04 00:00:00 EDT 2021
A Therapeutic Strategy for Preferential Targeting of TET2 Mutant and TET-dioxygenase Deficient Cells in Myeloid Neoplasms.
Blood cancer discovery
Guan Y,Tiwari AD,Phillips JG,Hasipek M,Grabowski DR,Pagliuca S,Gopal P,Kerr CM,Adema V,Radivoyevitch T,Parker Y,Lindner DJ,Meggendorfer M,Abazeed M,Sekeres MA,Mian OY,Haferlach T,Maciejewski JP,Jha BK
11-0453 was used in Flow cytometry/Cell sorting to suggest that TET inhibitors may constitute a new class of targeted agents in TET2 mutant neoplasia.
Mon Mar 01 00:00:00 EST 2021
Ddb1 Is Essential for the Expansion of CD4+ Helper T Cells by Regulating Cell Cycle Progression and Cell Death.
Frontiers in immunology
Yang L,Chen W,Li L,Xiao Y,Fan S,Zhang Q,Xia T,Li M,Hong Y,Zhao T,Li Q,Liu WH,Xiao N
Published figure using CD45.1 monoclonal antibody (Product # 11-0453-82) in Flow Cytometry
Mon Dec 20 00:00:00 EST 2021
Kidney tissue hypoxia dictates T cell-mediated injury in murine lupus nephritis.
Science translational medicine
Chen PM,Wilson PC,Shyer JA,Veselits M,Steach HR,Cui C,Moeckel G,Clark MR,Craft J
11-0453-82 was used in Functional assay to elucidate the mechanisms of immune cell adaptation to kidney tissue and subsequent damage in murine lupus nephritis.
Wed Apr 08 00:00:00 EDT 2020
Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.
The Journal of experimental medicine
Kang YA,Pietras EM,Passegué E
Published figure using CD45.1 monoclonal antibody (Product # 11-0453-82) in Flow Cytometry
Mon Mar 02 00:00:00 EST 2020
Activated PI3Kδ breaches multiple B cell tolerance checkpoints and causes autoantibody production.
The Journal of experimental medicine
Lau A,Avery DT,Jackson K,Lenthall H,Volpi S,Brigden H,Russell AJ,Bier J,Reed JH,Smart JM,Cole T,Choo S,Gray PE,Berglund LJ,Hsu P,Wong M,O'Sullivan M,Boztug K,Meyts I,Uzel G,Notarangelo LD,Brink R,Goodnow CC,Tangye SG,Deenick EK
11-0453-82 was used in Flow Cytometry to understand the role of PI3K signalling in regulating B cells during antibody-mediated autoimmune diseases.
Mon Feb 03 00:00:00 EST 2020
Snai2 Maintains Bone Marrow Niche Cells by Repressing Osteopontin Expression.
Developmental cell
Wei Q,Nakahara F,Asada N,Zhang D,Gao X,Xu C,Alfieri A,Brodin NP,Zimmerman SE,Mar JC,Guha C,Guo W,Frenette PS
11-0453-82 was used in Flow Cytometry to conclude that SNAI2 is a critical regulator of the transcriptional network maintaining MSPCs by the suppression of osteopontin expression.
Mon Jun 08 00:00:00 EDT 2020
RIPK3 and Caspase-1/11 Are Necessary for Optimal Antigen-Specific CD8 T Cell Response Elicited by Genetically Modified Listeria monocytogenes.
Frontiers in immunology
Rana A,de Almeida FC,Paico Montero HA,Gonzales Carazas MM,Bortoluci KR,Sad S,Amarante-Mendes GP
Published figure using CD45.1 monoclonal antibody (Product # 11-0453-82) in Flow Cytometry
Fri Mar 26 00:00:00 EDT 2021
Hhex Directly Represses BIM-Dependent Apoptosis to Promote NK Cell Development and Maintenance.
Cell reports
Goh W,Scheer S,Jackson JT,Hediyeh-Zadeh S,Delconte RB,Schuster IS,Andoniou CE,Rautela J,Degli-Esposti MA,Davis MJ,McCormack MP,Nutt SL,Huntington ND
11-0453 was used in Flow cytometry/Cell sorting to show homeobox transcriptional regulator Hhex regulates NK cell homeostasis and immunity.
Tue Oct 20 00:00:00 EDT 2020
Engineering monocyte/macrophage-specific glucocerebrosidase expression in human hematopoietic stem cells using genome editing.
Nature communications
Scharenberg SG,Poletto E,Lucot KL,Colella P,Sheikali A,Montine TJ,Porteus MH,Gomez-Ospina N
Published figure using CD45.1 monoclonal antibody (Product # 11-0453-82) in Flow Cytometry
Fri Jul 03 00:00:00 EDT 2020
The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction.
Cell
Collins N,Han SJ,Enamorado M,Link VM,Huang B,Moseman EA,Kishton RJ,Shannon JP,Dixit D,Schwab SR,Hickman HD,Restifo NP,McGavern DB,Schwartzberg PL,Belkaid Y
11-0453-82 was used in Flow Cytometry to show that memory T cells collapsed in secondary lymphoid organs in the context of dietary restriction (DR) but dramatically accumulated within the bone marrow (BM), where they adopted a state associated with energy conservation.
Thu Aug 22 00:00:00 EDT 2019
The Chemoattractant Receptor Ebi2 Drives Intranodal Naive CD4+ T Cell Peripheralization to Promote Effective Adaptive Immunity.
Immunity
Baptista AP,Gola A,Huang Y,Milanez-Almeida P,Torabi-Parizi P,Urban JF,Shapiro VS,Gerner MY,Germain RN
11-0453 was used in Flow cytometry/Cell sorting to demonstrate evolutionary selection for distinct niches within the LN that promote cellular responses, emphasizing the critical link between fine-grained tissue organization and host defense.
Tue May 21 00:00:00 EDT 2019
Engineering a haematopoietic stem cell niche by revitalizing mesenchymal stromal cells.
Nature cell biology
Nakahara F,Borger DK,Wei Q,Pinho S,Maryanovich M,Zahalka AH,Suzuki M,Cruz CD,Wang Z,Xu C,Boulais PE,Ma'ayan A,Greally JM,Frenette PS
11-0453-82 was used in Flow Cytometry to provide insight into the transcriptional regulation of the niche with implications for stem cell-based therapies.
Wed May 01 00:00:00 EDT 2019
Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence.
Journal of visualized experiments : JoVE
Kesarwani M,Kincaid Z,Azam M
11-0453 was used in Flow cytometry/Cell sorting to provide methods for target validation using in vitro and in vivo mouse models.
Mon Jan 07 00:00:00 EST 2019
Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence.
Journal of visualized experiments : JoVE
Kesarwani M,Kincaid Z,Azam M
11-0453 was used in Flow cytometry/Cell sorting to provide methods for target validation using in vitro and in vivo mouse models.
Mon Jan 07 00:00:00 EST 2019
Keap1-Nrf2 System Plays an Important Role in Invariant Natural Killer T Cell Development and Homeostasis.
Cell reports
Pyaram K,Kumar A,Kim YH,Noel S,Reddy SP,Rabb H,Chang CH
11-0453 was used in Flow cytometry/Cell sorting to report that T cellspecific deletion of Keap1 results in defective development and reduced numbers of invariant natural killer T (NKT) cells in the thymus and the peripheral organs in a cell-intrinsic manner.
Tue Apr 16 00:00:00 EDT 2019
Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche.
Nature medicine
Maryanovich M,Zahalka AH,Pierce H,Pinho S,Nakahara F,Asada N,Wei Q,Wang X,Ciero P,Xu J,Leftin A,Frenette PS
11-0453 was used in Flow cytometry/Cell sorting to determine whether haematopoietic stem cell ageing depends on bone marrow innervation by the sympathetic nervous system.
Fri Jun 01 00:00:00 EDT 2018
Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells.
Cell
Gaya M,Barral P,Burbage M,Aggarwal S,Montaner B,Warren Navia A,Aid M,Tsui C,Maldonado P,Nair U,Ghneim K,Fallon PG,Sekaly RP,Barouch DH,Shalek AK,Bruckbauer A,Strid J,Batista FD
Published figure using CD45.1 monoclonal antibody (Product # 11-0453-82) in Flow Cytometry
Thu Jan 25 00:00:00 EST 2018
A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion.
Immunity
Xia P,Wang S,Ye B,Du Y,Li C,Xiong Z,Qu Y,Fan Z
11-0453 was used in Flow cytometry/Cell sorting to study circular RNA-mediated maintenance of hematopoeitic stem cell homeostasis.
Tue Apr 17 00:00:00 EDT 2018
Effector CD4 T cells with progenitor potential mediate chronic intestinal inflammation.
The Journal of experimental medicine
Shin B,Kress RL,Kramer PA,Darley-Usmar VM,Bellis SL,Harrington LE
11-0453 was used in Flow cytometry/Cell sorting to indicate that the chronicity of T cell-mediated inflammation is perpetuated by specific effector CD4 T cells with stem-like properties.
Mon Jul 02 00:00:00 EDT 2018
Neutrophil and Macrophage Cell Surface Colony-Stimulating Factor 1 Shed by ADAM17 Drives Mouse Macrophage Proliferation in Acute and Chronic Inflammation.
Molecular and cellular biology
Tang J,Frey JM,Wilson CL,Moncada-Pazos A,Levet C,Freeman M,Rosenfeld ME,Stanley ER,Raines EW,Bornfeldt KE
11-0453 was used in Flow cytometry/Cell sorting to identify a significant defect in macrophage proliferation in mice lacking leukocyte transmembrane protease, ADAM17.
Sat Sep 01 00:00:00 EDT 2018
The H3K4 methyltransferase Setd1b is essential for hematopoietic stem and progenitor cell homeostasis in mice.
eLife
Schmidt K,Zhang Q,Tasdogan A,Petzold A,Dahl A,Arneth BM,Slany R,Fehling HJ,Kranz A,Stewart AF,Anastassiadis K
Published figure using CD45.1 monoclonal antibody (Product # 11-0453-82) in Flow Cytometry
Tue Jun 19 00:00:00 EDT 2018
An immune cell spray (ICS) formulation allows for the delivery of functional monocyte/macrophages.
Scientific reports
Beneke V,Küster F,Neehus AL,Hesse C,Lopez-Rodriguez E,Haake K,Rafiei Hashtchin A,Schott JW,Walter D,Braun A,Wolkers WF,Ackermann M,Lachmann N
Published figure using CD45.1 monoclonal antibody (Product # 11-0453-82) in Flow Cytometry
Fri Nov 02 00:00:00 EDT 2018
Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress.
Cell stem cell
Tadokoro Y,Hoshii T,Yamazaki S,Eto K,Ema H,Kobayashi M,Ueno M,Ohta K,Arai Y,Hara E,Harada K,Oshima M,Oshima H,Arai F,Yoshimura A,Nakauchi H,Hirao A
11-0453-82 was used in Flow Cytometry to demonstrate the involvement of diet-induced stress on hematopoietic stem cell self-renewal.
Thu May 03 00:00:00 EDT 2018
Type 2 Innate Lymphocytes Actuate Immunity Against Tumours and Limit Cancer Metastasis.
Scientific reports
Saranchova I,Han J,Zaman R,Arora H,Huang H,Fenninger F,Choi KB,Munro L,Pfeifer CG,Welch I,Takei F,Jefferies WA
11-0453 was used in Flow cytometry/Cell sorting to study the role of type 2 innate lymphoid cells in enhancing anti-cancer immunity and controlling metastasis.
Tue Feb 13 00:00:00 EST 2018
Transcription factors early growth response gene (Egr) 2 and 3 control inflammatory responses of tolerant T cells.
Immunity, inflammation and disease
Omodho B,Miao T,Symonds ALJ,Singh R,Li S,Wang P
Fri Jun 01 00:00:00 EDT 2018
TGF-β1 Negatively Regulates the Number and Function of Hematopoietic Stem Cells.
Stem cell reports
Wang X,Dong F,Zhang S,Yang W,Yu W,Wang Z,Zhang S,Wang J,Ma S,Wu P,Gao Y,Dong J,Tang F,Cheng T,Ema H
11-0453 was used in Flow cytometry/Cell sorting to examine the effect of transforming growth factor Β1 on haematopoietic stem cell function.
Tue Jul 10 00:00:00 EDT 2018
Store-Operated Ca2+ Entry Controls Clonal Expansion of T Cells through Metabolic Reprogramming.
Immunity
Vaeth M,Maus M,Klein-Hessling S,Freinkman E,Yang J,Eckstein M,Cameron S,Turvey SE,Serfling E,Berberich-Siebelt F,Possemato R,Feske S
Tue Oct 17 00:00:00 EDT 2017
Dichotomous Expression of TNF Superfamily Ligands on Antigen-Presenting Cells Controls Post-priming Anti-viral CD4+ T Cell Immunity.
Immunity
Chang YH,Wang KC,Chu KL,Clouthier DL,Tran AT,Torres Perez MS,Zhou AC,Abdul-Sater AA,Watts TH
11-0453-82 was used in Flow Cytometry to investigate how different subtypes of T cell antigen-presenting cell contribute to determining viral set point and disease outcome.
Tue Nov 21 00:00:00 EST 2017
Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.
The Journal of experimental medicine
Miao T,Symonds ALJ,Singh R,Symonds JD,Ogbe A,Omodho B,Zhu B,Li S,Wang P
Mon Jun 05 00:00:00 EDT 2017
Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.
The Journal of experimental medicine
Miao T,Symonds ALJ,Singh R,Symonds JD,Ogbe A,Omodho B,Zhu B,Li S,Wang P
Mon Jun 05 00:00:00 EDT 2017
Neoantigen Expression in Steady-State Langerhans Cells Induces CTL Tolerance.
Journal of immunology (Baltimore, Md. : 1950)
Strandt H,Pinheiro DF,Kaplan DH,Wirth D,Gratz IK,Hammerl P,Thalhamer J,Stoecklinger A
11-0453 was used in Immunocytochemistry to study the function of Langerhans cells in vivo, without altering the dendritic cell subset composition in the skin.
Fri Sep 01 00:00:00 EDT 2017
Chemokine Receptor-Dependent Control of Skin Tissue-Resident Memory T Cell Formation.
Journal of immunology (Baltimore, Md. : 1950)
Zaid A,Hor JL,Christo SN,Groom JR,Heath WR,Mackay LK,Mueller SN
11-0453 was used in Flow cytometry/Cell sorting to examine the signals required for the migration of tissue-resident memory T cells within the constrained epidermal environment.
Sun Oct 01 00:00:00 EDT 2017
Hepatic stroma-educated regulatory DCs suppress CD8+ T cell proliferation in mice.
Oncotarget
Wang Q,He H,Chen D,Wang C,Xu Y,Song W
11-0453 was used in Flow cytometry/Cell sorting to assess whether and how liver dendritic cells suppress CD8+ T cells.
Tue Nov 07 00:00:00 EST 2017
The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity.
Cell
Damgaard RB,Walker JA,Marco-Casanova P,Morgan NV,Titheradge HL,Elliott PR,McHale D,Maher ER,McKenzie ANJ,Komander D
Published figure using CD45.1 monoclonal antibody (Product # 11-0453-82) in Flow Cytometry
Thu Aug 25 00:00:00 EDT 2016
NFκB1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells.
The Journal of experimental medicine
de Valle E,Grigoriadis G,O'Reilly LA,Willis SN,Maxwell MJ,Corcoran LM,Tsantikos E,Cornish JK,Fairfax KA,Vasanthakumar A,Febbraio MA,Hibbs ML,Pellegrini M,Banerjee A,Hodgkin PD,Kallies A,Mackay F,Strasser A,Gerondakis S,Gugasyan R
11-0453 was used in Flow cytometry/Cell sorting to identify a novel role of NFκB1 in preventing multiorgan autoimmunity through the negative regulation of Il-6 gene expression in follicular B cells.
Mon Apr 04 00:00:00 EDT 2016
Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency.
Stem cell reports
Mucci A,Kunkiel J,Suzuki T,Brennig S,Glage S,Kühnel MP,Ackermann M,Happle C,Kuhn A,Schambach A,Trapnell BC,Hansen G,Moritz T,Lachmann N
Published figure using CD45.1 monoclonal antibody (Product # 11-0453-82) in Flow Cytometry
Tue Aug 09 00:00:00 EDT 2016
CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity.
Nature communications
Jacoby E,Nguyen SM,Fountaine TJ,Welp K,Gryder B,Qin H,Yang Y,Chien CD,Seif AE,Lei H,Song YK,Khan J,Lee DW,Mackall CL,Gardner RA,Jensen MC,Shern JF,Fry TJ
11-0453 was used in Flow cytometry/Cell sorting to study how CD19 CAR immune pressure induces a B-precursor acute lymphoblastic leukaemia lineage switch.
Wed Jul 27 00:00:00 EDT 2016
Single Targeted Exon Mutation Creates a True Congenic Mouse for Competitive Hematopoietic Stem Cell Transplantation: The C57BL/6-CD45.1(STEM) Mouse.
Stem cell reports
Mercier FE,Sykes DB,Scadden DT
11-0453 was used in Flow cytometry/Cell sorting to define the molecular regulators of hematopoietic stem and progenitor cells using a novel C57BL/6-CD45.1(STEM) mouse model.
Tue Jun 14 00:00:00 EDT 2016
Inhibition of Inflammation and iNOS Improves Lymphatic Function in Obesity.
Scientific reports
Torrisi JS,Hespe GE,Cuzzone DA,Savetsky IL,Nitti MD,Gardenier JC,García Nores GD,Jowhar D,Kataru RP,Mehrara BJ
11-0453 was used in Flow cytometry/Cell sorting to study the cellular mechanisms regulating decreased lymphatic function found in obesity, showing that inhibition of inflammation and iNOS improves lymphatic function.
Fri Jan 22 00:00:00 EST 2016
Discovery of a Metastatic Immune Escape Mechanism Initiated by the Loss of Expression of the Tumour Biomarker Interleukin-33.
Scientific reports
Saranchova I,Han J,Huang H,Fenninger F,Choi KB,Munro L,Pfeifer C,Welch I,Wyatt AW,Fazli L,Gleave ME,Jefferies WA
11-0453 was used in Flow cytometry/Cell sorting to investigate the role of IL-33 in cancer immune-surveillance against primary tumours.
Tue Sep 13 00:00:00 EDT 2016
BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival.
The Journal of experimental medicine
Jacque E,Schweighoffer E,Tybulewicz VL,Ley SC
11-0453 was used in Flow cytometry/Cell sorting to reveal a potentially critical role for the MEK5-ERK5 MAP kinase signalling pathway in BAFF-induced mature B cell survival and homeostatic maintenance of B2 cell numbers.
Mon Jun 01 00:00:00 EDT 2015
MHC-mismatched mixed chimerism augments thymic regulatory T-cell production and prevents relapse of EAE in mice.
Proceedings of the National Academy of Sciences of the United States of America
Wu L,Li N,Zhang M,Xue SL,Cassady K,Lin Q,Riggs AD,Zeng D
Published figure using CD45.1 monoclonal antibody (Product # 11-0453-82) in Flow Cytometry
Tue Dec 29 00:00:00 EST 2015
Frizzled-6 Regulates Hematopoietic Stem/Progenitor Cell Survival and Self-Renewal.
Journal of immunology (Baltimore, Md. : 1950)
Abidin BM,Owusu Kwarteng E,Heinonen KM
11-0453 was used in Flow cytometry/Cell sorting to reveal that Fzd6 has an essential role in HSPC maintenance and survival.
Tue Sep 01 00:00:00 EDT 2015
Alternatively activated macrophages promote pancreatic fibrosis in chronic pancreatitis.
Nature communications
Xue J,Sharma V,Hsieh MH,Chawla A,Murali R,Pandol SJ,Habtezion A
Published figure using CD45.1 monoclonal antibody (Product # 11-0453-82) in Flow Cytometry
Mon May 18 00:00:00 EDT 2015
Deltex1 antagonizes HIF-1α and sustains the stability of regulatory T cells in vivo.
Nature communications
Hsiao HW,Hsu TS,Liu WH,Hsieh WC,Chou TF,Wu YJ,Jiang ST,Lai MZ
11-0453 was used in Flow cytometry/Cell sorting to investigate how Foxp3 and Treg stability is regulated in vivo, showing that Deltex1 antagonizes HIF-1α and sustains the stability of Tregs.
Thu Feb 19 00:00:00 EST 2015
STAT4 controls GM-CSF production by both Th1 and Th17 cells during EAE.
Journal of neuroinflammation
McWilliams IL,Rajbhandari R,Nozell S,Benveniste E,Harrington LE
11-0453 was used in Flow cytometry/Cell sorting to establish the role of STAT4 in the regulation of cytokine production during experimental autoimmune encephalomyelitis pathogenesis.
Tue Jun 30 00:00:00 EDT 2015
Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion.
Nature medicine
Bruns I,Lucas D,Pinho S,Ahmed J,Lambert MP,Kunisaki Y,Scheiermann C,Schiff L,Poncz M,Bergman A,Frenette PS
11-0453 was used in Flow cytometry/Cell sorting to indicate that a terminally differentiated cell type derived from HSCs contributes to the HSC niche, directly regulating HSC behavior.
Sat Nov 01 00:00:00 EDT 2014
Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages.
Cell
Haldar M,Kohyama M,So AY,Kc W,Wu X,Briseño CG,Satpathy AT,Kretzer NM,Arase H,Rajasekaran NS,Wang L,Egawa T,Igarashi K,Baltimore D,Murphy TL,Murphy KM
Published figure using CD45.1 monoclonal antibody (Product # 11-0453-82) in Flow Cytometry
Thu Mar 13 00:00:00 EDT 2014
Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development.
Nature immunology
Au-Yeung BB,Melichar HJ,Ross JO,Cheng DA,Zikherman J,Shokat KM,Robey EA,Weiss A
11-0453 was used in Flow cytometry/Cell sorting to show that CD4(+)CD8(+) thymocytes integrate multiple, transient, Zap70-dependent signals over more than 36 h to reach a cumulative threshold for positive selection.
Tue Jul 01 00:00:00 EDT 2014
Cdk4 and Cdk6 cooperate in counteracting the INK4 family of inhibitors during murine leukemogenesis.
Blood
Rodríguez-Díez E,Quereda V,Bellutti F,Prchal-Murphy M,Partida D,Eguren M,Kollmann K,Gómez de Cedrón M,Dubus P,Cañamero M,Martínez D,Sexl V,Malumbres M
11-0453 was used in Flow cytometry/Cell sorting to assess the role of Cdk4 and Cdk6 cooperation during the development of hematopoietic tumours.
Thu Oct 09 00:00:00 EDT 2014
Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model.
The Journal of clinical investigation
Bestas B,Moreno PM,Blomberg KE,Mohammad DK,Saleh AF,Sutlu T,Nordin JZ,Guterstam P,Gustafsson MO,Kharazi S,Piątosa B,Roberts TC,Behlke MA,Wood MJ,Gait MJ,Lundin KE,El Andaloussi S,Månsson R,Berglöf A,Wengel J,Smith CI
11-0453 was used in Flow cytometry/Cell sorting to assess the potential of antisense splice-correcting oligonucleotides targeting mutated Bruton's tyrosine kinase transcripts for treating X-linked agammaglobulinemia.
Mon Sep 01 00:00:00 EDT 2014
WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner.
The Journal of experimental medicine
Xia P,Wang S,Huang G,Zhu P,Li M,Ye B,Du Y,Fan Z
Published figure using CD45.1 monoclonal antibody (Product # 11-0453-82) in Flow Cytometry
Mon Sep 22 00:00:00 EDT 2014
Boosting functional avidity of CD8+ T cells by vaccinia virus vaccination depends on intrinsic T-cell MyD88 expression but not the inflammatory milieu.
Journal of virology
Hu Z,Wang J,Wan Y,Zhu L,Ren X,Qiu S,Ren Y,Yuan S,Ding X,Chen J,Qiu C,Sun J,Zhang X,Xiang J,Qiu C,Xu J
11-0453 was used in Flow cytometry/Cell sorting to investigate how vaccinia-vectored vaccine (VACV) shapes the properties of memory CD8+ T cells, showing that it depends on intrinsic T-cell MyD88 expression.
Thu May 01 00:00:00 EDT 2014
E and Id proteins influence invariant NKT cell sublineage differentiation and proliferation.
Journal of immunology (Baltimore, Md. : 1950)
D'Cruz LM,Stradner MH,Yang CY,Goldrath AW
11-0453 was used in Flow cytometry/Cell sorting to investigate the mechanism by which E and Id proteins control the development of invariant NKT sublineages after positive selection.
Sat Mar 01 00:00:00 EST 2014
The transcription factor E74-like factor 4 suppresses differentiation of proliferating CD4+ T cells to the Th17 lineage.
Journal of immunology (Baltimore, Md. : 1950)
Lee PH,Puppi M,Schluns KS,Yu-Lee LY,Dong C,Lacorazza HD
11-0453 was used in Flow cytometry/Cell sorting to purified cells CD4+ T cells are inhibited from differentiating into Th17 cells by E74-like Factor 4.
Wed Jan 01 00:00:00 EST 2014
Administration of the resveratrol analogues isorhapontigenin and heyneanol-A protects mice hematopoietic cells against irradiation injuries.
BioMed research international
Wang H,Yang YL,Zhang H,Yan H,Wu XJ,Zhang CZ
11-0453 was used in Flow cytometry/Cell sorting to examine if isorhapontigenin and heyneanol-A, two analogues of resveratrol, could mitigate IR-induced BM suppression.
Mon Mar 30 00:00:00 EDT 2015
BMP-non-responsive Sca1+ CD73+ CD44+ mouse bone marrow derived osteoprogenitor cells respond to combination of VEGF and BMP-6 to display enhanced osteoblastic differentiation and ectopic bone formation.
PloS one
Madhu V,Li CJ,Dighe AS,Balian G,Cui Q
11-0453 was used in Flow cytometry/Cell sorting to study how combined action of VEGF and BMP on MSCs enhances osteoblastic differentiation of MSCs and increases their bone forming ability.
Fri Nov 20 00:00:00 EST 2015
Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4⁺ T cell immunity.
Nature immunology
Reis BS,Rogoz A,Costa-Pinto FA,Taniuchi I,Mucida D
Published figure using CD45.1 monoclonal antibody (Product # 11-0453-82) in Flow Cytometry
Fri Mar 01 00:00:00 EST 2013
Direct effects of IL-4 on mast cells drive their intestinal expansion and increase susceptibility to anaphylaxis in a murine model of food allergy.
Mucosal immunology
Burton OT,Darling AR,Zhou JS,Noval-Rivas M,Jones TG,Gurish MF,Chatila TA,Oettgen HC
11-0453 was used in Flow cytometry/Cell sorting to demonstrate that IL-4-signaling is a key determinant of mast cell expansion in food allergy.
Mon Jul 01 00:00:00 EDT 2013
c-Rel is an essential transcription factor for the development of acute graft-versus-host disease in mice.
European journal of immunology
Yu Y,Wang D,Kaosaard K,Liu C,Fu J,Haarberg K,Anasetti C,Beg AA,Yu XZ
11-0453 was used in Flow cytometry/Cell sorting to investigate the role of c-Rel in transplant tolerance and graft-versus-host disease (GVHD), showing that it is an essential transcription factor for the development of acute GVHD.
Sun Sep 01 00:00:00 EDT 2013
Arrayed lentiviral barcoding for quantification analysis of hematopoietic dynamics.
Stem cells (Dayton, Ohio)
Grosselin J,Sii-Felice K,Payen E,Chretien S,Tronik-Le Roux D,Leboulch P
Published figure using CD45.1 monoclonal antibody (Product # 11-0453-82) in Flow Cytometry
Tue Oct 01 00:00:00 EDT 2013
A non-redundant function of cyclin E1 in hematopoietic stem cells.
Cell cycle (Georgetown, Tex.)
Campaner S,Viale A,De Fazio S,Doni M,De Franco F,D'Artista L,Sardella D,Pelicci PG,Amati B
11-0453 was used in Flow cytometry/Cell sorting to support a role for cyclin E1 in controlling the exit from quiescence in hematopoietic stem cells.
Sun Dec 01 00:00:00 EST 2013
G-CSF/anti-G-CSF antibody complexes drive the potent recovery and expansion of CD11b+Gr-1+ myeloid cells without compromising CD8+ T cell immune responses.
Journal of hematology & oncology
Rubinstein MP,Salem ML,Doedens AL,Moore CJ,Chiuzan C,Rivell GL,Cole DJ,Goldrath AW
11-0453 was used in Flow cytometry/Cell sorting to evaluate whether the biological activity of G-CSF can be improved by pre-association with anti-G-CSF monoclonal antibodies prior to injection.
Tue Oct 01 00:00:00 EDT 2013
CD8 T cells induce T-bet-dependent migration toward CXCR3 ligands by differentiated B cells produced during responses to alum-protein vaccines.
Blood
Serre K,Cunningham AF,Coughlan RE,Lino AC,Rot A,Hub E,Moser K,Manz R,Ferraro A,Bird R,Toellner KM,Demengeot J,MacLennan IC,Mohr E
11-0453 was used in Flow cytometry/Cell sorting to identify a mechanism that induces CXCR3 expression by AFC and germinal center B cells.
Thu Nov 29 00:00:00 EST 2012
A germinal center-independent pathway generates unswitched memory B cells early in the primary response.
The Journal of experimental medicine
Taylor JJ,Pape KA,Jenkins MK
11-0453 was used in Flow cytometry/Cell sorting to assess the relative contributions of GC-dependent or GC-independent pathways to the polyclonal memory B cell pool.
Mon Mar 12 00:00:00 EDT 2012
A critical role for Rictor in T lymphopoiesis.
Journal of immunology (Baltimore, Md. : 1950)
Tang F,Wu Q,Ikenoue T,Guan KL,Liu Y,Zheng P
11-0453 was used in Flow cytometry/Cell sorting to investigate the signalling pathway required for T lymphopoiesis, showing a critical role for Rictor.
Wed Aug 15 00:00:00 EDT 2012
In vitro Ag Cross-presentation and in vivo Ag Cross-presentation by Dendritic Cells in the Mouse.
Bio-protocol
Ghosh M,Shapiro LH
Published figure using CD45.1 monoclonal antibody (Product # 11-0453-82) in Flow Cytometry
Thu Dec 20 00:00:00 EST 2012
Prevention and mitigation of acute radiation syndrome in mice by synthetic lipopeptide agonists of Toll-like receptor 2 (TLR2).
PloS one
Shakhov AN,Singh VK,Bone F,Cheney A,Kononov Y,Krasnov P,Bratanova-Toshkova TK,Shakhova VV,Young J,Weil MM,Panoskaltsis-Mortari A,Orschell CM,Baker PS,Gudkov A,Feinstein E
11-0453 was used in Flow cytometry/Cell sorting to illustrate the strong potential of LP-based TLR2 agonists for anti-radiation prophylaxis and therapy in defence and medical scenarios.
Tue Aug 28 00:00:00 EDT 2012
Hyaluronan expressed by the hematopoietic microenvironment is required for bone marrow hematopoiesis.
The Journal of biological chemistry
Goncharova V,Serobyan N,Iizuka S,Schraufstatter I,de Ridder A,Povaliy T,Wacker V,Itano N,Kimata K,Orlovskaja IA,Yamaguchi Y,Khaldoyanidi S
11-0453 was used in Flow cytometry/Cell sorting to examine the contribution of hyaluronan to the regulatory network of the haematopoietic microenvironment.
Fri Jul 20 00:00:00 EDT 2012
Prevention of GVHD while sparing GVL effect by targeting Th1 and Th17 transcription factor T-bet and RORγt in mice.
Blood
Yu Y,Wang D,Liu C,Kaosaard K,Semple K,Anasetti C,Yu XZ
11-0453 was used in Flow cytometry/Cell sorting to indicate that GVHD can be prevented by targeting Th1 and Th17 transcription factors without offsetting GVL activity.
Thu Nov 03 00:00:00 EDT 2011
Hierarchical organization and early hematopoietic specification of the developing HSC lineage in the AGM region.
The Journal of experimental medicine
Rybtsov S,Sobiesiak M,Taoudi S,Souilhol C,Senserrich J,Liakhovitskaia A,Ivanovs A,Frampton J,Zhao S,Medvinsky A
11-0453 was used in Flow cytometry/Cell sorting to show that pre-HSCs are broadly distributed through the wall of the dorsal aorta, and propose a simple model for HSC development in the AGM region.
Mon Jun 06 00:00:00 EDT 2011
Toll-like receptor 4 is a regulator of monocyte and electroencephalographic responses to sleep loss.
Sleep
Wisor JP,Clegern WC,Schmidt MA
11-0453 was used in Flow cytometry/Cell sorting to describe the baseline electroencephalographic sleep phenotype and the biochemical and electroencephalographic responses to sleep loss in TLR4-deficient mice.
Sat Oct 01 00:00:00 EDT 2011
Nonhematopoietic antigen blocks memory programming of alloreactive CD8+ T cells and drives their eventual exhaustion in mouse models of bone marrow transplantation.
The Journal of clinical investigation
Flutter B,Edwards N,Fallah-Arani F,Henderson S,Chai JG,Sivakumaran S,Ghorashian S,Bennett CL,Freeman GJ,Sykes M,Chakraverty R
11-0453 was used in Flow cytometry/Cell sorting to explore the role of recipient antigen expression by nonhaematopoietic cells in the failure to sustain effective cytotoxic T lymphocyte immunity following blood transplantation.
Mon Nov 01 00:00:00 EDT 2010
miR-33-mediated downregulation of p53 controls hematopoietic stem cell self-renewal.
Cell cycle (Georgetown, Tex.)
Herrera-Merchan A,Cerrato C,Luengo G,Dominguez O,Piris MA,Serrano M,Gonzalez S
11-0453 was used in Immunocytochemistry to define the role of miR-33 in controlling HSC self-renewal through p53.
Sun Aug 15 00:00:00 EDT 2010
Commitment to the regulatory T cell lineage requires CARMA1 in the thymus but not in the periphery.
PLoS biology
Barnes MJ,Krebs P,Harris N,Eidenschenk C,Gonzalez-Quintial R,Arnold CN,Crozat K,Sovath S,Moresco EM,Theofilopoulos AN,Beutler B,Hoebe K
11-0453 was used in Flow cytometry/Cell sorting to investigate methods to distinguish between Tregs of thymic or peripheral origin, showing that commitment requires CARMA1 in the thymus but not in the periphery.
Tue Mar 03 00:00:00 EST 2009
Transplantation of embryonic spleen tissue reveals a role for adult non-lymphoid cells in initiating lymphoid tissue organization.
European journal of immunology
Glanville SH,Bekiaris V,Jenkinson EJ,Lane PJ,Anderson G,Withers DR
11-0453 was used in Flow cytometry/Cell sorting to analyse the cellular and molecular requirements for the development and organisation of splenic microenvironments.
Thu Jan 01 00:00:00 EST 2009
Signal transduction inhibition of APCs diminishes th17 and Th1 responses in experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Skarica M,Wang T,McCadden E,Kardian D,Calabresi PA,Small D,Whartenby KA
11-0453 was used in Flow cytometry/Cell sorting to show that targeted inhibition of DCs in EAE-infected mice leads to a decrease in CNS infiltration of pathogenic Ag-specific T cells.
Wed Apr 01 00:00:00 EDT 2009
Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge.
Journal of immunology (Baltimore, Md. : 1950)
Hamada H,Garcia-Hernandez Mde L,Reome JB,Misra SK,Strutt TM,McKinstry KK,Cooper AM,Swain SL,Dutton RW
11-0453 was used in Flow cytometry/Cell sorting to study the role of Tc17 cells in influenza infection, showing that they protect against lethality.
Sun Mar 15 00:00:00 EDT 2009
IL-7 and IL-15 differentially regulate CD8+ T-cell subsets during contraction of the immune response.
Blood
Rubinstein MP,Lind NA,Purton JF,Filippou P,Best JA,McGhee PA,Surh CD,Goldrath AW
11-0453 was used in Flow cytometry/Cell sorting to study IL-7 and IL-15 regulation of CD8+ T-cell subsets during contraction of the immune response.
Sat Nov 01 00:00:00 EDT 2008
Importance of CD80/CD86-CD28 interactions in the recognition of target cells by CD8+CD122+ regulatory T cells.
Immunology
Shi Z,Rifa'i M,Lee YH,Shiku H,Isobe K,Suzuki H
11-0453 was used in Flow cytometry/Cell sorting to investigate the molecular mechanisms responsible for the recognition of target cells by CD8+CD122+ regulatory T cells.
Thu May 01 00:00:00 EDT 2008
Programmed death ligand 1 regulates a critical checkpoint for autoimmune myocarditis and pneumonitis in MRL mice.
Journal of immunology (Baltimore, Md. : 1950)
Lucas JA,Menke J,Rabacal WA,Schoen FJ,Sharpe AH,Kelley VR
11-0453 was used in Flow cytometry/Cell sorting to compare kidney and systemic illness in PD-L1 null and PD-L1 intact mouse models of lupus.
Fri Aug 15 00:00:00 EDT 2008
Combined anti-CD40 conditioning and well-timed immunization prolongs CD8+ T cell accumulation and control of established brain tumors.
Journal of immunotherapy (Hagerstown, Md. : 1997)
Ryan CM,Staveley-O'Carroll K,Schell TD
11-0453 was used in Flow cytometry/Cell sorting to investigate the augmentation of CD8+ T-cell-mediated adoptive immunotherapy by targeting a weakly immunogenic epitope.
Mon Jul 13 00:00:00 EDT 2009
An intense form of homeostatic proliferation of naive CD8+ cells driven by IL-2.
The Journal of experimental medicine
Cho JH,Boyman O,Kim HO,Hahm B,Rubinstein MP,Ramsey C,Kim DM,Surh CD,Sprent J
11-0453 was used in Flow cytometry/Cell sorting to describe a novel form of homeostatic proliferation that occurs when naive T cells encounter raised levels of IL-2 and IL-15 in vivo.
Mon Aug 06 00:00:00 EDT 2007
Presenilins regulate alphabeta T cell development by modulating TCR signaling.
The Journal of experimental medicine
Laky K,Fowlkes BJ
11-0453 was used in Flow cytometry/Cell sorting to suggest a model in which PS-dependent Notch signalling influences positive selection and the development of alphabeta T cells by modifying TCR signal transduction.
Mon Sep 03 00:00:00 EDT 2007
Immature hematopoietic cells display selective requirements for adhesion- and degranulation-promoting adaptor protein in development and homeostatsis.
European journal of immunology
Dluzniewska J,Zou L,Harmon IR,Ellingson MT,Peterson EJ
11-0453-82 was used in Flow Cytometry to highlight the dynamic regulation of ADAP during T cell maturation and document expression patterns that suggest a possible role for ADAP in development of non-T hematopoietic lineages.
Thu Nov 01 00:00:00 EDT 2007
Essential roles of CD8+CD122+ regulatory T cells in the maintenance of T cell homeostasis.
The Journal of experimental medicine
Rifa'i M,Kawamoto Y,Nakashima I,Suzuki H
11-0453 was used in Flow cytometry/Cell sorting to investigate the effect of transfer of CD8+CD122+ cells into CD122-deficient neonates, showing that CD8+CD122+ regulatory T cells are essential for T cell homeostasis.
Mon Nov 01 00:00:00 EST 2004
