Product References
TIGIT enhances CD4+ regulatory T-cell response and mediates immune suppression in a murine ovarian cancer model.
Cancer medicine
Chen F,Xu Y,Chen Y,Shan S
MCD0430 was used in Flow cytometry/Cell sorting to reveal crucial functions of TIGIT in the development and progression of ovarian cancer (OC).
Fri May 01 00:00:00 EDT 2020
Antisense STAT3 inhibitor decreases viability of myelodysplastic and leukemic stem cells.
The Journal of clinical investigation
Shastri A,Choudhary G,Teixeira M,Gordon-Mitchell S,Ramachandra N,Bernard L,Bhattacharyya S,Lopez R,Pradhan K,Giricz O,Ravipati G,Wong LF,Cole S,Bhagat TD,Feld J,Dhar Y,Bartenstein M,Thiruthuvanathan VJ,Wickrema A,Ye BH,Frank DA,Pellagatti A,Boultwood J,Zhou T,Kim Y,MacLeod AR,Epling-Burnette PK,Ye M,McCoon P,Woessner R,Steidl U,Will B,Verma A
MCD0430 was used in Flow cytometry/Cell sorting to demonstrate that STAT3 is an adverse prognostic factor in myelodysplastic syndromes/acute myeloid leukaemia, and to provide a preclinical rationale for studies using AZD9150 in these diseases.
Mon Dec 03 00:00:00 EST 2018
Interleukin 4 promotes the development of ex-Foxp3 Th2 cells during immunity to intestinal helminths.
The Journal of experimental medicine
Pelly VS,Coomes SM,Kannan Y,Gialitakis M,Entwistle LJ,Perez-Lloret J,Czieso S,Okoye IS,Rückerl D,Allen JE,Brombacher F,Wilson MS
MCD0430 was used in Flow cytometry/Cell sorting to indicate that converting T reg cells into Th2 cells could concomitantly enhance Th2 cells and limit T reg cell-mediated suppression.
Mon Jun 05 00:00:00 EDT 2017
Blood pressure regulation by CD4+ lymphocytes expressing choline acetyltransferase.
Nature biotechnology
Olofsson PS,Steinberg BE,Sobbi R,Cox MA,Ahmed MN,Oswald M,Szekeres F,Hanes WM,Introini A,Liu SF,Holodick NE,Rothstein TL,Lövdahl C,Chavan SS,Yang H,Pavlov VA,Broliden K,Andersson U,Diamond B,Miller EJ,Arner A,Gregersen PK,Backx PH,Mak TW,Tracey KJ
MCD0430 was used in flow cytometry to elucidate how CD4 positive T cells help regulate blood pressure
Sat Oct 01 00:00:00 EDT 2016
Acute systemic DNA damage in youth does not impair immune defense with aging.
Aging cell
Pugh JL,Foster SA,Sukhina AS,Petravic J,Uhrlaub JL,Padilla-Torres J,Hayashi T,Nakachi K,Smithey MJ,Nikolich-Žugich J
Published figure using CD4 monoclonal antibody (Product # MCD0430) in Flow Cytometry
Mon Aug 01 00:00:00 EDT 2016
IL-4-producing ILC2s are required for the differentiation of TH2 cells following Heligmosomoides polygyrus infection.
Mucosal immunology
Pelly VS,Kannan Y,Coomes SM,Entwistle LJ,Rückerl D,Seddon B,MacDonald AS,McKenzie A,Wilson MS
MCD0430 was used in Flow cytometry/Cell sorting to highlight a previously unrecognised and important role for ILC2-derived IL-4 for TH2 differentiation in a natural TH2-dependent model of human helminthiasis.
Tue Nov 01 00:00:00 EDT 2016
Trypanosoma cruzi Causes Paralyzing Systemic Necrotizing Vasculitis Driven by Pathogen-Specific Type I Immunity in Mice.
Infection and immunity
Roffê E,Marino APMP,Weaver J,Wan W,de Araújo FF,Hoffman V,Santiago HC,Murphy PM
MCD0430 was used in flow cytometry to demonstrate that control of acute infection with Trypanosoma cruzi is associated with development of systemic necrotizing vasculitis
Fri Apr 01 00:00:00 EDT 2016
Experimental cerebral malaria pathogenesis--hemodynamics at the blood brain barrier.
PLoS pathogens
Nacer A,Movila A,Sohet F,Girgis NM,Gundra UM,Loke P,Daneman R,Frevert U
MCD0430 was used in flow cytometry to evaluate a model of cerebral malaria pathogenesis and its effect on the blood brain barrier
Mon Dec 01 00:00:00 EST 2014
Ectopic TBX1 suppresses thymic epithelial cell differentiation and proliferation during thymus organogenesis.
Development (Cambridge, England)
Reeh KA,Cardenas KT,Bain VE,Liu Z,Laurent M,Manley NR,Richie ER
MCD0430 was used in flow cytometry to assess the contribution of Tbx1 to thymus and parathyroid development
Fri Aug 01 00:00:00 EDT 2014
Influence of natural killer cells and perforin‑mediated cytolysis on the development of chemically induced lung cancer in A/J mice.
Cancer immunology, immunotherapy : CII
Frese-Schaper M,Keil A,Yagita H,Steiner SK,Falk W,Schmid RA,Frese S
MCD0430 was used in flow cytometry to determine which type of immune cells contributes to the protection from lung cancer development.
Sun Jun 01 00:00:00 EDT 2014
Siglec-G deficiency leads to more severe collagen-induced arthritis and earlier onset of lupus-like symptoms in MRL/lpr mice.
Journal of immunology (Baltimore, Md. : 1950)
Bökers S,Urbat A,Daniel C,Amann K,Smith KG,Espéli M,Nitschke L
MCD0430 was used in Flow cytometry/Cell sorting to study how loss of the inhibitory receptor Siglec-G led to a moderate exacerbation of disease severity and early onset in both collagen-induced arthritis and spontaneous lupus nephritis.
Tue Apr 01 00:00:00 EDT 2014
Self-recognition of the endothelium enables regulatory T-cell trafficking and defines the kinetics of immune regulation.
Nature communications
Fu H,Kishore M,Gittens B,Wang G,Coe D,Komarowska I,Infante E,Ridley AJ,Cooper D,Perretti M,Marelli-Berg FM
MCD0430 was used in flow cytometry to study the involvement of endothelium in efficient Treg T cell recruitment in vivo
Fri Mar 14 00:00:00 EDT 2014
Interleukin-4 regulates eomesodermin in CD8+ T cell development and differentiation.
PloS one
Carty SA,Koretzky GA,Jordan MS
MCD0430 was used in flow cytometry to examine the role of interleukin-4 in relation to eomesodermin within CD8+ T cells
Thu May 21 00:00:00 EDT 2015
IL-21 is a double-edged sword in the systemic lupus erythematosus-like disease of BXSB.Yaa mice.
Journal of immunology (Baltimore, Md. : 1950)
McPhee CG,Bubier JA,Sproule TJ,Park G,Steinbuck MP,Schott WH,Christianson GJ,Morse HC,Roopenian DC
MCD0430 was used in flow cytometry to generate mice that lack IL-2R on B cells, on all T cells, or on CD8(+) T cells alone and examine the effects on systemic lupus erythematosus-like autoimmune disease.
Fri Nov 01 00:00:00 EDT 2013
Thymic medullar conduits-associated podoplanin promotes natural regulatory T cells.
Immunology letters
Fuertbauer E,Zaujec J,Uhrin P,Raab I,Weber M,Schachner H,Bauer M,Schütz GJ,Binder BR,Sixt M,Kerjaschki D,Stockinger H
MCD0430 was used in flow cytometry to characterize mice deficient in podoplanin and explore the effect of podoplanin modulation on T cell populations.
Mon Jul 14 00:00:00 EDT 2014
BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs.
Nature
Mathew R,Seiler MP,Scanlon ST,Mao AP,Constantinides MG,Bertozzi-Villa C,Singer JD,Bendelac A
MCD0430 was used in immunohistochemistry to investigate the role of BTB-ZF factors in lymphoid effector programs
Thu Nov 22 00:00:00 EST 2012
MHC class I family proteins retard systemic lupus erythematosus autoimmunity and B cell lymphomagenesis.
Journal of immunology (Baltimore, Md. : 1950)
McPhee CG,Sproule TJ,Shin DM,Bubier JA,Schott WH,Steinbuck MP,Avenesyan L,Morse HC,Roopenian DC
MCD0430 was used in flow cytometry to determine the contributions of individual MHC class I family members to autoimmunity in two mouse models.
Tue Nov 01 00:00:00 EDT 2011
MHC class I family proteins retard systemic lupus erythematosus autoimmunity and B cell lymphomagenesis.
Journal of immunology (Baltimore, Md. : 1950)
McPhee CG,Sproule TJ,Shin DM,Bubier JA,Schott WH,Steinbuck MP,Avenesyan L,Morse HC,Roopenian DC
MCD0430 was used in flow cytometry to determine the contributions of individual MHC class I family members to autoimmunity in two mouse models.
Tue Nov 01 00:00:00 EDT 2011
Respiratory Francisella tularensis live vaccine strain infection induces Th17 cells and prostaglandin E2, which inhibits generation of gamma interferon-positive T cells.
Infection and immunity
Woolard MD,Hensley LL,Kawula TH,Frelinger JA
MCD0430 was used in Flow Cytometry to illuminate a critical differences in acute adaptive immune responses between inhalational and dermal infection with F. tularensis LVS.
Sun Jun 01 00:00:00 EDT 2008
A transgenic mouse model genetically tags all activated CD8 T cells.
Journal of immunology (Baltimore, Md. : 1950)
Maris CH,Miller JD,Altman JD,Jacob J
MCD0430 was used in flow cytometry to track the dynamics of the antiviral CD8+ T cell responses using a transgenic mouse that marks activated T cells.
Mon Sep 01 00:00:00 EDT 2003
