Product References
Immunostimulatory effects of a subcritical water extract of Ganoderma.
Biomedical reports
Hattori K,Takagi H,Ogata Y,Yamada T,Horiba H,Fukata K,Sakaida T,Yashiro Y,Hasegawa S,Tanaka H
11-0341-82 was used in Flow cytometry/Cell sorting to demonstrate that Ganoderma (SWEG) increased hematopoietic precursor cells, immature B cells, and NK cells in the bone marrow, and T cells in the thymus.
Sun Jan 01 00:00:00 EST 2023
R274X-mutated Phf6 increased the self-renewal and skewed T cell differentiation of hematopoietic stem cells.
iScience
Lan Y,Yuan S,Guo T,Hou S,Zhao F,Yang W,Cao Y,Chu Y,Jiang E,Yuan W,Wang X
11-0341-82 was used in Flow cytometry/Cell sorting to demonstrate that Phf6R274X plays a critical role in fine-tuning T cells and HSC homeostasis.
Fri Jun 16 00:00:00 EDT 2023
Reduced graphene oxide-embedded nerve conduits loaded with bone marrow mesenchymal stem cell-derived extracellular vesicles promote peripheral nerve regeneration.
Neural regeneration research
Zhang W,Fang XX,Li QC,Pi W,Han N
11-0341-82 was used in Flow cytometry/Cell sorting to indicate that rGO-GelMA-PCL nerve conduits loaded with BMSC-derived extracellular vesicles can promote peripheral nerve regeneration and neurological function recovery, and provide a new direction for the curation of peripheral nerve defect in the clinic.
Sun Jan 01 00:00:00 EST 2023
Exosomal miR-17-5p from adipose-derived mesenchymal stem cells inhibits abdominal aortic aneurysm by suppressing TXNIP-NLRP3 inflammasome.
Stem cell research & therapy
Hu J,Jiang Y,Wu X,Wu Z,Qin J,Zhao Z,Li B,Xu Z,Lu X,Wang X,Liu X
11-0341-82 was used in Flow cytometry/Cell sorting to examine the function and mechanism of adipose-derived mesenchymal stem cells -derived exosomes (ADSC-exos) and their microRNA-17-5p (miR-17-5p) on the abdominal aortic aneurysm (AAA) progression.
Tue Jul 26 00:00:00 EDT 2022
Massive expansion of multiple clones in the mouse hematopoietic system long after whole-body X-irradiation.
Scientific reports
Yoshida K,Satoh Y,Uchimura A,Misumi M,Kyoizumi S,Taga M,Matsuda Y,Noda A,Kusunoki Y
11-0341-82 was used in Flow cytometry/Cell sorting to reveal development of massive CH; with increases in peripheral blood myeloid cells, red blood cell distribution width and recurrent somatic mutations, due to radiation exposure.
Fri Oct 14 00:00:00 EDT 2022
Adiponectin receptors sustain haematopoietic stem cells throughout adulthood by protecting them from inflammation.
Nature cell biology
Meacham CE,Jeffery EC,Burgess RJ,Sivakumar CD,Arora MA,Stanley AM,Colby EM,Crane GM,Zhao Z,Morrison SJ
11-0341-82 was used in Flow cytometry/Cell sorting to find that adiponectin receptors are non-cell-autonomously required in haematopoietic cells to promote HSC quiescence and self-renewal.
Sun May 01 00:00:00 EDT 2022
Thy1 marks a distinct population of slow-cycling stem cells in the mouse epidermis.
Nature communications
Koren E,Feldman A,Yusupova M,Kadosh A,Sedov E,Ankawa R,Yosefzon Y,Nasser W,Gerstberger S,Kimel LB,Priselac N,Brown S,Sharma S,Gorenc T,Shalom-Feuerstein R,Steller H,Shemesh T,Fuchs Y
11-0341-82 was used in Flow cytometry/Cell sorting to report a population of keratinocytes, marked by Thy1, in the basal layer of the interfollicular epidermis.
Mon Aug 08 00:00:00 EDT 2022
Transplantation of adipose-derived stem cells ameliorates Echinococcus multilocularis-induced liver fibrosis in mice.
PLoS neglected tropical diseases
Yang N,Ma W,Ke Y,Liu H,Chu J,Sun L,Lü G,Bi X,Lin R
11-0341-82 was used in Flow Cytometry to find that ADSCs transplantation significantly down-regulated TGF-β1 and TGF-βR expressions, while up-regulating Smad7 expression in the TGF-β/Smad signaling pathway.
Sat Jan 01 00:00:00 EST 2022
Maternal inappropriate calcium intake aggravates dietary-induced obesity in male offspring by affecting the differentiation potential of mesenchymal stem cells.
World journal of stem cells
Li P,Wang Y,Li P,Liu YL,Liu WJ,Chen XY,Tang TT,Qi KM,Zhang Y
11-0341-82 was used in Flow cytometry/Cell sorting to show that early-life abnormal dietary calcium intake might program the adipogenic differentiation potential of BMSCs from male offspring, with significant expressions on the Wnt/β-catenin signaling pathway to aggravate high-fat-diet-induced obesity in adulthood.
Wed Oct 26 00:00:00 EDT 2022
TRAF6 functions as a tumor suppressor in myeloid malignancies by directly targeting MYC oncogenic activity.
Cell stem cell
Muto T,Guillamot M,Yeung J,Fang J,Bennett J,Nadorp B,Lasry A,Redondo LZ,Choi K,Gong Y,Walker CS,Hueneman K,Bolanos LC,Barreyro L,Lee LH,Greis KD,Vasyliev N,Khodadadi-Jamayran A,Nudler E,Lujambio A,Lowe SW,Aifantis I,Starczynowski DT
11-0341-82 was used in Flow cytometry/Cell sorting to identify signaling states that cooperate with pre-leukemic cells and, notably, the study aimed to uncover the role of the ubiquitin ligase TRAF6 in preventing the transition from a pre-leukemic stage to overt myeloid leukemia by regulating MYC through ubiquitination and acetylation mechanisms.
Thu Feb 03 00:00:00 EST 2022
Chaperone-mediated autophagy sustains haematopoietic stem-cell function.
Nature
Dong S,Wang Q,Kao YR,Diaz A,Tasset I,Kaushik S,Thiruthuvanathan V,Zintiridou A,Nieves E,Dzieciatkowska M,Reisz JA,Gavathiotis E,D'Alessandro A,Will B,Cuervo AM
11-0341-82 was used in Flow Cytometry to show that chaperone-mediated autophagy is involved in sustaining haematopoietic stem cells function in adult mice.
Mon Mar 01 00:00:00 EST 2021
Photoreceptor protection by mesenchymal stem cell transplantation identifies exosomal MiR-21 as a therapeutic for retinal degeneration.
Cell death and differentiation
Deng CL,Hu CB,Ling ST,Zhao N,Bao LH,Zhou F,Xiong YC,Chen T,Sui BD,Yu XR,Hu CH
11-0341 was used in Flow cytometry/Cell sorting to discover that intravitreal MSCT counteracted photoreceptor apoptosis and alleviate retinal morphological and functional degeneration in a mouse model of photoreceptor loss induced by N-methyl-N-nitrosourea (MNU).
Mon Mar 01 00:00:00 EST 2021
γ-Tocotrienol-Loaded Liposomes for Radioprotection from Hematopoietic Side Effects Caused by Radiotherapeutic Drugs.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Lee SG,Kalidindi TM,Lou H,Gangangari K,Punzalan B,Bitton A,Lee CJ,Vargas HA,Park S,Bodei L,Kharas MG,Singh VK,Kishore Pillarsetty NV,Larson SM
11-0341 was used in Flow cytometry/Cell sorting to report a novel radioprotector drug, a liposomal formulation of gamma-tocotrienol (GT3), or GT3-Nano for short, to mitigate bone marrow radiation damage during targeted radionuclide therapy (TRT).
Thu Apr 01 00:00:00 EDT 2021
Induction of osteogenic differentiation of bone marrow stromal cells on 3D polyester-based scaffolds solely by subphysiological fluidic stimulation in a laminar flow bioreactor.
Journal of tissue engineering
Yamada S,Yassin MA,Schwarz T,Hansmann J,Mustafa K
11-0341-82 was used in Flow Cytometry to study osteogenesis initiation in synthetic environments as stimulated by a laminar flow bioreactor.
Fri Jul 16 00:00:00 EDT 2021
Functional damage of endothelial progenitor cells is attenuated by 14-3-3-n through inhibition of mitochondrial injury and oxidative stress.
Cell biology international
Li Y,Sun X,Zhang X,Zhou H,Wang D,Xia Y,Li X
11-0341-82 was used in Cell Culture to provide a new target, 14-3-3-η, for the prevention and treatment of cardiovascular diseases through targeting EPCs.
Thu Apr 01 00:00:00 EDT 2021
Differential activation of Ca2+ influx channels modulate stem cell potency, their proliferation/viability and tissue regeneration.
NPJ Regenerative medicine
Ahamad N,Sun Y,Nascimento Da Conceicao V,Xavier Paul Ezhilan CRD,Natarajan M,Singh BB
11-0341-82 was used in Immunohistochemistry to establish the molecular identity of the calcium channel in MSCs and also show their role in modulating stem cell function.
Wed Oct 20 00:00:00 EDT 2021
Modulation of miR-29a and ADAM12 Reduces Post-Ischemic Skeletal Muscle Injury and Improves Perfusion Recovery and Skeletal Muscle Function in a Mouse Model of Type 2 Diabetes and Peripheral Artery Disease.
International journal of molecular sciences
Lamin V,Verry J,Eigner-Bybee I,Fuqua JD,Wong T,Lira VA,Dokun AO
11-0341-82 was used in Flow Cytometry to show that inhibition of miR-29a and or augmentation of ADAM12 improves experimental PAD outcomes in DM2 likely through modulation of Tie 2 and AKT signalling.
Fri Dec 31 00:00:00 EST 2021
Inhibition of Rag GTPase signaling in mice suppresses B cell responses and lymphomagenesis with minimal detrimental trade-offs.
Cell reports
Ortega-Molina A,Lebrero-Fernández C,Sanz A,Deleyto-Seldas N,Plata-Gómez AB,Menéndez C,Graña-Castro O,Caleiras E,Efeyan A
11-0341-82 was used in Flow Cytometry to support the efficacy and safety of moderate inhibition of nutrient signaling against pathological B cells.
Tue Jul 13 00:00:00 EDT 2021
The ESCRT-0 subcomplex component Hrs/Hgs is a master regulator of myogenesis via modulation of signaling and degradation pathways.
BMC biology
Coudert L,Osseni A,Gangloff YG,Schaeffer L,Leblanc P
11-0341-82 was used in Flow Cytometry to show for the first time that Hrs/Hgs is a master regulator that modulates myogenesis at different levels through the control of trafficking, signaling, and degradation pathways.
Fri Jul 30 00:00:00 EDT 2021
Mesenchymal stem cell exosome-derived miR-223 alleviates acute graft-versus-host disease via reducing the migration of donor T cells.
Stem cell research & therapy
Liu W,Zhou N,Liu Y,Zhang W,Li X,Wang Y,Zheng R,Zhang Y
11-0341-82 was used in Flow cytometry/Cell sorting to unveil a new role of MSCs-Exo containing miR-223 in the treatment of acute graft-versus-host disease (aGvHD).
Fri Feb 26 00:00:00 EST 2021
Therapeutic Potential of Mesenchymal Stem Cells in a Pre-Clinical Model of Diabetic Kidney Disease and Obesity.
International journal of molecular sciences
Sávio-Silva C,Soinski-Sousa PE,Simplício-Filho A,Bastos RMC,Beyerstedt S,Rangel ÉB
11-0341-82 was used in Flow cytometry/Cell sorting to investigate mitochondria damage induced by hyperglycemia-driven reactive species oxygen (ROS) accumulation and verified whether mesenchymal stem cells (MSCs) anti-oxidative, anti-apoptotic, autophagy modulation, and pro-mitochondria homeostasis therapeutic potential curtailed T2DM-DKD progression.
Thu Feb 04 00:00:00 EST 2021
Increasing cytosolic Ca2+ levels restore cell proliferation and stem cell potency in aged MSCs.
Stem cell research
Ahamad N,Sun Y,Singh BB
11-0341-82 was used in Cell Culture to suggest that Ca2+ entry is essential for preventing the loss of aged stem cell function and supplementing Ca2+ not only restored their proliferative potential but, allowed them to develop into younger stem cell lineages that could be critical for regenerative medicine.
Fri Oct 01 00:00:00 EDT 2021
Establishment of a fluorescent reporter of RNA-polymerase II activity to identify dormant cells.
Nature communications
Freter R,Falletta P,Omrani O,Rasa M,Herbert K,Annunziata F,Minetti A,Krepelova A,Adam L,Käppel S,Rüdiger T,Wang ZQ,Goding CR,Neri F
11-0341-82 was used in Immunocytochemistry to identify a dormant OSCARhigh cell population in the small intestine.
Thu Jun 03 00:00:00 EDT 2021
Mesenchymal stem cells ameliorate renal fibrosis by galectin-3/Akt/GSK3β/Snail signaling pathway in adenine-induced nephropathy rat.
Stem cell research & therapy
Tang H,Zhang P,Zeng L,Zhao Y,Xie L,Chen B
11-0341-82 was used in Flow Cytometry to explore a new mechanism and therapeutic target of mesenchymal stromal cells against renal fibrosis based on renal proteomics.
Fri Jul 16 00:00:00 EDT 2021
Differences in the reaction of hyperlipidemia on different endothelial progenitor cells based on sex.
Biomedical reports
Zhuo X,Bu H,Hu K,Si Z,Chen L,Chen Y,Yang L,Jiang Y,Xu Y,Zhao P,Ma X,Tao S,Zhu Q,Cui L,Sun H,Cui Y
11-0341-82 was used in Flow Cytometry to compare the effects of sex under conditions of hyperlipidemia on different populations of EPCs, and to identify the potential underlying mechanisms.
Sun Aug 01 00:00:00 EDT 2021
Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity.
Cell
Kalafati L,Kourtzelis I,Schulte-Schrepping J,Li X,Hatzioannou A,Grinenko T,Hagag E,Sinha A,Has C,Dietz S,de Jesus Domingues AM,Nati M,Sormendi S,Neuwirth A,Chatzigeorgiou A,Ziogas A,Lesche M,Dahl A,Henry I,Subramanian P,Wielockx B,Murray P,Mirtschink P,Chung KJ,Schultze JL,Netea MG,Hajishengallis G,Verginis P,Mitroulis I,Chavakis T
11-0341 was used in Flow cytometry/Cell sorting to identify a novel and therapeutically relevant anti-tumor facet of trained immunity involving appropriate rewiring of granulopoiesis.
Thu Oct 29 00:00:00 EDT 2020
m6A Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development.
Immunity
Gao Y,Vasic R,Song Y,Teng R,Liu C,Gbyli R,Biancon G,Nelakanti R,Lobben K,Kudo E,Liu W,Ardasheva A,Fu X,Wang X,Joshi P,Lee V,Dura B,Viero G,Iwasaki A,Fan R,Xiao A,Flavell RA,Li HB,Tebaldi T,Halene S
11-0341-82 was used in Flow Cytometry to investigate if N6-methyladenosine modification protects against endogenous double-stranded RNAs formation and a deleterious innate immune response during mammalian hematopoietic development.
Tue Jun 16 00:00:00 EDT 2020
Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.
The Journal of experimental medicine
Kang YA,Pietras EM,Passegué E
11-0341 was used in Flow cytometry/Cell sorting to uncover a mechanism that controls myeloid regeneration and early lineage decisions in HSCs and could be targeted in LSCs to normalize leukemic myeloid cell production.
Mon Mar 02 00:00:00 EST 2020
Long-term ex vivo expansion of mouse hematopoietic stem cells.
Nature protocols
Wilkinson AC,Ishida R,Nakauchi H,Yamazaki S
11-0341 was used in Flow cytometry/Cell sorting to describe a simple platform for the expansion of functional mouse hematopoietic stem cells ex vivo for >1 month under fully defined albumin-free conditions.
Sat Feb 01 00:00:00 EST 2020
Sema3A and HIF1α co-overexpressed iPSC-MSCs/HA scaffold facilitates the repair of calvarial defect in a mouse model.
Journal of cellular physiology
Li J,Wang T,Li C,Wang Z,Wang P,Zheng L
11-0341-82 was used in Flow cytometry/Cell sorting to show that Sema3A and HIF1α co-overexpression reversed the reduced cell proliferation that reduced by Sema3A overexpression alone.
Thu Oct 01 00:00:00 EDT 2020
Mesenchymal Stem Cells Provide Neuroprotection by Regulating Heat Stroke-Induced Brain Inflammation.
Frontiers in neurology
Zhang Y,Deng Z,Li Y,Yuan R,Yang M,Zhao Y,Wang L,Zhou F,Kang H
11-0341 was used in Flow cytometry/Cell sorting to explore the neuroprotective effects and mechanisms of mesenchymal stem cells (MSCs) against heat stroke (HS)-induced CNS injury.
Mon Sep 28 00:00:00 EDT 2020
Silencing of RBP‑JK promotes the differentiation of bone marrow mesenchymal stem cells into vascular endothelial cells.
Molecular medicine reports
Luo Z,Dai Y,Chen M,Zhu C,Wu K,Li G,Shang X
11-0341 was used in Flow cytometry/Cell sorting to demonstrate that silencing of RBP-JK promotes differentiation of bone marrow mesenchymal stem cells into vascular endothelial cells, a promising therapeutic basis for the treatment of bone defects.
Wed Jan 01 00:00:00 EST 2020
Protective effect and mechanism of mesenchymal stem cells on heat stroke induced intestinal injury.
Experimental and therapeutic medicine
Wang L,Deng Z,Yuan R,Zhao Y,Yang M,Hu J,Zhang Y,Li Y,Zhou F,Kang H
11-0341 was used in Flow cytometry/Cell sorting to indicate that MSCs may be used as a potential method to treat HS and the resulting organ dysfunction.
Thu Oct 01 00:00:00 EDT 2020
Effects of CD4+ T lymphocytes from ovariectomized mice on bone marrow mesenchymal stem cell proliferation and osteogenic differentiation.
Experimental and therapeutic medicine
Shao BY,Wang L,Yu Y,Chen L,Gan N,Huang WM
11-0341 was used in Flow cytometry/Cell sorting to investigate the effects of T cells on the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells (BMMSCs).
Sun Nov 01 00:00:00 EDT 2020
Site-1 protease ablation in the osterix-lineage in mice results in bone marrow neutrophilia and hematopoietic stem cell alterations.
Biology open
Patra D,Kim J,Zhang Q,Tycksen E,Sandell LJ
11-0341 was used in Flow cytometry/Cell sorting to show that S1P has a role in the lineage specification of hematopoietic stem cells and/or their progenitors for development of a normal hematopoietic niche.
Tue Jun 23 00:00:00 EDT 2020
Icariin Promote Stem Cells Regeneration and Repair Acinar Cells in L-arginine / Radiation -Inducing Chronic Pancreatitis in Rats.
Dose-response : a publication of International Hormesis Society
Moustafa EM,Moawed FSM,Abdel-Hamid GR
11-0341-82 was used in Flow Cytometry to evaluate the ability of bone marrow-based mesenchymal stem cell combined with Icariin to restore and regenerate acinar cells in the pancreas of rats suffering chronic pancreatitis.
Mon Apr 18 00:00:00 EDT 2022
GDNF promotes hair formation and cutaneous wound healing by targeting bulge stem cells.
NPJ Regenerative medicine
Lisse TS,Sharma M,Vishlaghi N,Pullagura SR,Braun RE
11-0341 was used in Flow cytometry/Cell sorting to reveal that GDNF promotes hair formation and wound repair and that bulge stem cells are critical mediators of both.
Sat Jul 03 00:00:00 EDT 2021
Mesenchymal Stromal Cells Derived from Bone Marrow and Adipose Tissue: Isolation, Culture, Characterization and Differentiation.
Bio-protocol
Freitas GP,Souza ATP,Lopes HB,Trevisan RLB,Oliveira FS,Fernandes RR,Ferreira FU,Ros FA,Beloti MM,Rosa AL
11-0341 was used in Flow cytometry/Cell sorting to describe protocols to isolate MSCs from bone marrow (BM-MSCs) and adipose tissues (AT-MSCs), and methods to culture, characterize, and differentiate MSCs into osteoblasts, adipocytes, and chondrocytes.
Thu Feb 20 00:00:00 EST 2020
Effect of Combining Low Temperature Plasma, Negative Pressure Wound Therapy, and Bone Marrow Mesenchymal Stem Cells on an Acute Skin Wound Healing Mouse Model.
International journal of molecular sciences
Cui HS,Joo SY,Cho YS,Park JH,Kim JB,Seo CH
11-0341 was used in Flow cytometry/Cell sorting to show combination therapy with LPT, NPWT, and MSC may be a promising strategy for treatment of acute wounds.
Sat May 23 00:00:00 EDT 2020
Modest Declines in Proteome Quality Impair Hematopoietic Stem Cell Self-Renewal.
Cell reports
Hidalgo San Jose L,Sunshine MJ,Dillingham CH,Chua BA,Kruta M,Hong Y,Hatters DM,Signer RAJ
11-0341 was used in Flow cytometry/Cell sorting to show that hematopoietic stem cells (HSCs) are dependent on low protein synthesis to maintain proteostasis, which promotes their self-renewal.
Tue Jan 07 00:00:00 EST 2020
Immunoadjuvant Activity of Fucoidans from the Brown Alga Fucus evanescens.
Marine drugs
Kuznetsova TA,Smolina TP,Makarenkova ID,Ivanushko LA,Persiyanova EV,Ermakova SP,Silchenko AS,Zaporozhets TS,Besednova NN,Fedyanina LN,Kryzhanovsky SP
11-0341 was used in Flow cytometry/Cell sorting to comparatively evaluate the effect of fucoidans from the brown alga Fucus evanescens on effector functions of innate and adaptive immunity cells in vitro and in vivo.
Wed Mar 11 00:00:00 EDT 2020
tagHi-C Reveals 3D Chromatin Architecture Dynamics during Mouse Hematopoiesis.
Cell reports
Zhang C,Xu Z,Yang S,Sun G,Jia L,Zheng Z,Gu Q,Tao W,Cheng T,Li C,Cheng H
11-0341-82 was used in Flow Cytometry to introduce a low-input tagmentation-based Hi-C (tagHi-C) method to capture the chromatin structures of hundreds of cells.
Tue Sep 29 00:00:00 EDT 2020
Proteomic analysis of young and old mouse hematopoietic stem cells and their progenitors reveals post-transcriptional regulation in stem cells.
eLife
Zaro BW,Noh JJ,Mascetti VL,Demeter J,George B,Zukowska M,Gulati GS,Sinha R,Flynn RA,Banuelos A,Zhang A,Wilkinson AC,Jackson P,Weissman IL
11-0341 was used in Flow cytometry/Cell sorting to report a proteomics resource from mass spectrometry of mouse young adult and old adult mouse hematopoietic stem cells, multipotent progenitors and oligopotent progenitors; 12 cell types in total.
Wed Nov 25 00:00:00 EST 2020
β4GALT1 controls β1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis.
Nature communications
Giannini S,Lee-Sundlov MM,Rivadeneyra L,Di Buduo CA,Burns R,Lau JT,Falet H,Balduini A,Hoffmeister KM
11-0341 was used in Flow cytometry/Cell sorting to identify the conserved B4galt1 gene as a critical regulator of thrombopoiesis in megakaryocytes.
Fri Jan 17 00:00:00 EST 2020
Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth.
Cell reports
Davidson S,Efremova M,Riedel A,Mahata B,Pramanik J,Huuhtanen J,Kar G,Vento-Tormo R,Hagai T,Chen X,Haniffa MA,Shields JD,Teichmann SA
11-0341-82 was used in Immunohistochemistry to identify complex interplays and increase stromal diversity as a tumor develops, revealing that stromal cells acquire the capacity to modulate immune landscapes from early disease.
Tue May 19 00:00:00 EDT 2020
Osterix-Cre marks distinct subsets of CD45- and CD45+ stromal populations in extra-skeletal tumors with pro-tumorigenic characteristics.
eLife
Ricci B,Tycksen E,Celik H,Belle JI,Fontana F,Civitelli R,Faccio R
11-0341 was used in Flow cytometry/Cell sorting to find Osx transcript and Osx protein expression early during hematopoiesis, in subsets of hematopoietic stem cells and multipotent progenitor populations.
Wed Aug 05 00:00:00 EDT 2020
Targeting Bim via a lncRNA Morrbid Regulates the Survival of Preleukemic and Leukemic Cells.
Cell reports
Cai Z,Aguilera F,Ramdas B,Daulatabad SV,Srivastava R,Kotzin JJ,Carroll M,Wertheim G,Williams A,Janga SC,Zhang C,Henao-Mejia J,Kapur R
11-0341 was used in Flow cytometry/Cell sorting to show that a lncRNA, MORRBID, a selective transcriptional repressor of BIM, is overexpressed in human acute myeloid leukemia (AML), which is associated with poor overall survival.
Tue Jun 23 00:00:00 EDT 2020
Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation.
Nature
Wilkinson AC,Ishida R,Kikuchi M,Sudo K,Morita M,Crisostomo RV,Yamamoto R,Loh KM,Nakamura Y,Watanabe M,Nakauchi H,Yamazaki S
11-0341 was used in Flow cytometry/Cell sorting to identify polyvinyl alcohol as a functionally superior replacement for serum albumin that is compatible with good manufacturing practice.
Mon Jul 01 00:00:00 EDT 2019
Sleep modulates haematopoiesis and protects against atherosclerosis.
Nature
McAlpine CS,Kiss MG,Rattik S,He S,Vassalli A,Valet C,Anzai A,Chan CT,Mindur JE,Kahles F,Poller WC,Frodermann V,Fenn AM,Gregory AF,Halle L,Iwamoto Y,Hoyer FF,Binder CJ,Libby P,Tafti M,Scammell TE,Nahrendorf M,Swirski FK
11-0341-82 was used in Flow Cytometry to investigate the cellular and molecular mechanisms by which sleep maintains cardiovascular health.
Fri Feb 01 00:00:00 EST 2019
Adaptive Immune Resistance Emerges from Tumor-Initiating Stem Cells.
Cell
Miao Y,Yang H,Levorse J,Yuan S,Polak L,Sribour M,Singh B,Rosenblum MD,Fuchs E
11-0341 was used in Flow cytometry/Cell sorting to place tSCs at the crux of how immune checkpoint pathways are activated.
Thu May 16 00:00:00 EDT 2019
The cis-Regulatory Atlas of the Mouse Immune System.
Cell
Yoshida H,Lareau CA,Ramirez RN,Rose SA,Maier B,Wroblewska A,Desland F,Chudnovskiy A,Mortha A,Dominguez C,Tellier J,Kim E,Dwyer D,Shinton S,Nabekura T,Qi Y,Yu B,Robinette M,Kim KW,Wagers A,Rhoads A,Nutt SL,Brown BD,Mostafavi S,Buenrostro JD,Benoist C
11-0341-82 was used in Flow Cytometry to generate matched epigenome and transcriptome measurements in 86 primary cell types that span the mouse immune system and its differentiation cascade.
Thu Feb 07 00:00:00 EST 2019
TNF-α Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration.
Cell stem cell
Yamashita M,Passegué E
11-0341 was used in Flow cytometry/Cell sorting to reveal several TNF-α-mediated pro-survival mechanisms unique to HSCs, highlight an important role for necroptosis in HSC killing, and establish TNF-α as a major pro-survival and pro-regeneration factor for HSCs.
Thu Sep 05 00:00:00 EDT 2019
Cohesin-mediated NF-κB signaling limits hematopoietic stem cell self-renewal in aging and inflammation.
The Journal of experimental medicine
Chen Z,Amro EM,Becker F,Hölzer M,Rasa SMM,Njeru SN,Han B,Di Sanzo S,Chen Y,Tang D,Tao S,Haenold R,Groth M,Romanov VS,Kirkpatrick JM,Kraus JM,Kestler HA,Marz M,Ori A,Neri F,Morita Y,Rudolph KL
11-0341 was used in Flow cytometry/Cell sorting to determine hematopoietic stem cell function is limited by Rad21/cohesin-mediated NF-kB signaling during aging.
Mon Jan 07 00:00:00 EST 2019
Dynamic expression of tRNA-derived small RNAs define cellular states.
EMBO reports
Krishna S,Yim DG,Lakshmanan V,Tirumalai V,Koh JL,Park JE,Cheong JK,Low JL,Lim MJ,Sze SK,Shivaprasad P,Gulyani A,Raghavan S,Palakodeti D,DasGupta R
11-0341-82 was used in Flow Cytometry to highlight the role of 5'-tsRNAs in defining distinct cell states.
Mon Jul 01 00:00:00 EDT 2019
Transcriptional Analysis of Sepsis-Induced Activation and Damage of the Adrenal Endothelial Microvascular Cells.
Frontiers in endocrinology
Chen LS,Singh SP,Müller G,Bornstein SR,Kanczkowski W
11-0341-82 was used in Immunohistochemistry to characterize transcriptomic alterations in isolated mouse adrenal microvascular endothelial cells induced by systemic administration of bacterial LPS.
Fri Feb 14 00:00:00 EST 2020
Lineage-specific RUNX2 super-enhancer activates MYC and promotes the development of blastic plasmacytoid dendritic cell neoplasm.
Nature communications
Kubota S,Tokunaga K,Umezu T,Yokomizo-Nakano T,Sun Y,Oshima M,Tan KT,Yang H,Kanai A,Iwanaga E,Asou N,Maeda T,Nakagata N,Iwama A,Ohyashiki K,Osato M,Sashida G
11-0341-82 was used in Flow cytometry/Cell sorting to demonstrate that a plasmacytoid dendritic cell-specific super-enhancer of RUNX2 is associated with the MYC promoter due to t(6;8).
Wed Apr 10 00:00:00 EDT 2019
In Situ Modification of Tissue Stem and Progenitor Cell Genomes.
Cell reports
Goldstein JM,Tabebordbar M,Zhu K,Wang LD,Messemer KA,Peacker B,Ashrafi Kakhki S,Gonzalez-Celeiro M,Shwartz Y,Cheng JKW,Xiao R,Barungi T,Albright C,Hsu YC,Vandenberghe LH,Wagers AJ
11-0341 was used in Flow cytometry/Cell sorting to demonstrate in vivo transduction of endogenous tissue stem cells in the muscle, blood, and skin by systemic or local administration of adeno-associated viruses (AAVs) encoding genome-modifying enzymes.
Tue Apr 23 00:00:00 EDT 2019
Noggin depletion in adipocytes promotes obesity in mice.
Molecular metabolism
Blázquez-Medela AM,Jumabay M,Rajbhandari P,Sallam T,Guo Y,Yao J,Vergnes L,Reue K,Zhang L,Yao Y,Fogelman AM,Tontonoz P,Lusis AJ,Wu X,Boström KI
11-0341-82 was used in Flow Cytometry to define the role of Noggin, an extracellular BMP inhibitor, in adipogenesis.
Mon Jul 01 00:00:00 EDT 2019
m6A RNA Methylation Maintains Hematopoietic Stem Cell Identity and Symmetric Commitment.
Cell reports
Cheng Y,Luo H,Izzo F,Pickering BF,Nguyen D,Myers R,Schurer A,Gourkanti S,Brüning JC,Vu LP,Jaffrey SR,Landau DA,Kharas MG
11-0341-82 was used in Flow cytometry/Cell sorting to indicate that RNA methylation controls symmetric commitment and cell identity of hematopoietic stem cells and may provide a general mechanism for how stem cells regulate differentiation fate choice.
Tue Aug 13 00:00:00 EDT 2019
The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance.
Cell stem cell
Vannini N,Campos V,Girotra M,Trachsel V,Rojas-Sutterlin S,Tratwal J,Ragusa S,Stefanidis E,Ryu D,Rainer PY,Nikitin G,Giger S,Li TY,Semilietof A,Oggier A,Yersin Y,Tauzin L,Pirinen E,Cheng WC,Ratajczak J,Canto C,Ehrbar M,Sizzano F,Petrova TV,Vanhecke D,Zhang L,Romero P,Nahimana A,Cherix S,Duchosal MA,Ho PC,Deplancke B,Coukos G,Auwerx J,Lutolf MP,Naveiras O
11-0341-82 was used in Flow Cytometry to demonstrate a positive effect of NAD+-boosting strategies on the most primitive blood stem cells, establishing a link between HSC mitochondrial stress, mitophagy, and stem-cell fate decision.
Thu Mar 07 00:00:00 EST 2019
N-Cadherin-Expressing Bone and Marrow Stromal Progenitor Cells Maintain Reserve Hematopoietic Stem Cells.
Cell reports
Zhao M,Tao F,Venkatraman A,Li Z,Smith SE,Unruh J,Chen S,Ward C,Qian P,Perry JM,Marshall H,Wang J,He XC,Li L
11-0341 was used in Flow cytometry/Cell sorting to report that N-cad+ cells were functional bone and marrow stromal progenitor cells, giving rise to osteoblasts, adipocytes, and chondrocytes both in vitro and in vivo.
Tue Jan 15 00:00:00 EST 2019
Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host.
Nature
Meisel M,Hinterleitner R,Pacis A,Chen L,Earley ZM,Mayassi T,Pierre JF,Ernest JD,Galipeau HJ,Thuille N,Bouziat R,Buscarlet M,Ringus DL,Wang Y,Li Y,Dinh V,Kim SM,McDonald BD,Zurenski MA,Musch MW,Furtado GC,Lira SA,Baier G,Chang EB,Eren AM,Weber CR,Busque L,Godley LA,Verdú EF,Barreiro LB,Jabri B
11-0341 was used in Flow cytometry/Cell sorting to study the role played by bacterial translocation and increased interleukin-6 production in the development of pre-leukaemic myeloproliferation.
Tue May 01 00:00:00 EDT 2018
Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity.
Cell
Mitroulis I,Ruppova K,Wang B,Chen LS,Grzybek M,Grinenko T,Eugster A,Troullinaki M,Palladini A,Kourtzelis I,Chatzigeorgiou A,Schlitzer A,Beyer M,Joosten LAB,Isermann B,Lesche M,Petzold A,Simons K,Henry I,Dahl A,Schultze JL,Wielockx B,Zamboni N,Mirtschink P,Coskun Ü,Hajishengallis G,Netea MG,Chavakis T
11-0341 was used in Flow cytometry/Cell sorting to discover that modulation of myeloid progenitors in the bone marrow is an integral component of trained immunity.
Thu Jan 11 00:00:00 EST 2018
Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations.
Cancer cell
Lee SC,North K,Kim E,Jang E,Obeng E,Lu SX,Liu B,Inoue D,Yoshimi A,Ki M,Yeo M,Zhang XJ,Kim MK,Cho H,Chung YR,Taylor J,Durham BH,Kim YJ,Pastore A,Monette S,Palacino J,Seiler M,Buonamici S,Smith PG,Ebert BL,Bradley RK,Abdel-Wahab O
11-0341 was used in Flow cytometry/Cell sorting to identify shared consequences of splicing-factor mutations and the basis for their mutual exclusivity.
Mon Aug 13 00:00:00 EDT 2018
Large-Scale Clonal Analysis Resolves Aging of the Mouse Hematopoietic Stem Cell Compartment.
Cell stem cell
Yamamoto R,Wilkinson AC,Ooehara J,Lan X,Lai CY,Nakauchi Y,Pritchard JK,Nakauchi H
11-0341 was used in Flow cytometry/Cell sorting to determine the age-related functional changes to the haematopoietic stem cell compartment.
Thu Apr 05 00:00:00 EDT 2018
Lack of Cardiac Improvement After Cardiosphere-Derived Cell Transplantation in Aging Mouse Hearts.
Circulation research
Zhao ZA,Han X,Lei W,Li J,Yang Z,Wu J,Yao M,Lu XA,He L,Chen Y,Zhou B,Hu S
11-0341 was used in Flow cytometry/Cell sorting to evaluate the effect of cardiosphere-derived cell injection on an ageing heart.
Fri Oct 26 00:00:00 EDT 2018
Bone marrow-derived fibroblasts are a functionally distinct stromal cell population in breast cancer.
The Journal of experimental medicine
Raz Y,Cohen N,Shani O,Bell RE,Novitskiy SV,Abramovitz L,Levy C,Milyavsky M,Leider-Trejo L,Moses HL,Grisaru D,Erez N
11-0341-82 was used in Flow Cytometry to conclude that PDGFRα expression distinguishes two functionally unique CAF populations in breast tumors and metastases and may have important implications for patient stratification and precision therapeutics.
Mon Dec 03 00:00:00 EST 2018
Attenuation of PKCδ enhances metabolic activity and promotes expansion of blood progenitors.
The EMBO journal
Rao TN,Gupta MK,Softic S,Wang LD,Jang YC,Thomou T,Bezy O,Kulkarni RN,Kahn CR,Wagers AJ
11-0341-82 was used in Flow Cytometry to identify PKCδ as a critical regulator of HSPC signalling and metabolism that acts to limit HSPC expansion in response to physiological and regenerative demands.
Fri Dec 14 00:00:00 EST 2018
miR-143/145 differentially regulate hematopoietic stem and progenitor activity through suppression of canonical TGFβ signaling.
Nature communications
Lam J,van den Bosch M,Wegrzyn J,Parker J,Ibrahim R,Slowski K,Chang L,Martinez-Høyer S,Condorelli G,Boldin M,Deng Y,Umlandt P,Fuller M,Karsan A
Wed Jun 20 00:00:00 EDT 2018
Retinoid-Sensitive Epigenetic Regulation of the Hoxb Cluster Maintains Normal Hematopoiesis and Inhibits Leukemogenesis.
Cell stem cell
Qian P,De Kumar B,He XC,Nolte C,Gogol M,Ahn Y,Chen S,Li Z,Xu H,Perry JM,Hu D,Tao F,Zhao M,Han Y,Hall K,Peak A,Paulson A,Zhao C,Venkatraman A,Box A,Perera A,Haug JS,Parmely T,Li H,Krumlauf R,Li L
11-0341 was used in Flow cytometry/Cell sorting to demonstrate roles for retinoid signaling and the DERARE in maintaining HSCs and preventing leukemogenesis by coordinate regulation of Hoxb genes.
Thu May 03 00:00:00 EDT 2018
Establishment of regulatory elements during erythro-megakaryopoiesis identifies hematopoietic lineage-commitment points.
Epigenetics & chromatin
Heuston EF,Keller CA,Lichtenberg J,Giardine B,Anderson SM,Hardison RC,Bodine DM
11-0341 was used in Flow cytometry/Cell sorting to demonstrate that megakaryopoietic profiles are established early in haematopoiesis and are present in the majority of the haematopoietic progenitor population.
Mon May 28 00:00:00 EDT 2018
AMPK Activation Regulates LTBP4-Dependent TGF-β1 Secretion by Pro-inflammatory Macrophages and Controls Fibrosis in Duchenne Muscular Dystrophy.
Cell reports
Juban G,Saclier M,Yacoub-Youssef H,Kernou A,Arnold L,Boisson C,Ben Larbi S,Magnan M,Cuvellier S,Théret M,Petrof BJ,Desguerre I,Gondin J,Mounier R,Chazaud B
11-0341 was used in Flow cytometry/Cell sorting to conclude that an AMPK-LTBP4 axis in inflammatory macrophages controls the production of TGF-β1, which is further activated by and acts on fibroblastic cells, leading to fibrosis in DMD.
Tue Nov 20 00:00:00 EST 2018
The Mesenchymal Niche of the Hair Follicle Induces Regeneration by Releasing Primed Progenitors from Inhibitory Effects of Quiescent Stem Cells.
Cell reports
Avigad Laron E,Aamar E,Enshell-Seijffers D
11-0341 was used in Immunocytochemistry-immunoflourescence to examine the role of the dermal papilla in governing the properties of quiescent stem cells in the bulge.
Tue Jul 24 00:00:00 EDT 2018
A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche.
Nature communications
Guarnerio J,Mendez LM,Asada N,Menon AV,Fung J,Berry K,Frenette PS,Ito K,Pandolfi PP
11-0341 was used in Flow cytometry/Cell sorting to show Pml in mesenchymal stem cells regulate pro-inflammatory cytokines which may sustain leukemic cells.
Thu Jan 04 00:00:00 EST 2018
TGF-β1 Negatively Regulates the Number and Function of Hematopoietic Stem Cells.
Stem cell reports
Wang X,Dong F,Zhang S,Yang W,Yu W,Wang Z,Zhang S,Wang J,Ma S,Wu P,Gao Y,Dong J,Tang F,Cheng T,Ema H
11-0341 was used in Flow cytometry/Cell sorting to examine the effect of transforming growth factor Β1 on haematopoietic stem cell function.
Tue Jul 10 00:00:00 EDT 2018
Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis.
Nature
Hérault A,Binnewies M,Leong S,Calero-Nieto FJ,Zhang SY,Kang YA,Wang X,Pietras EM,Chu SH,Barry-Holson K,Armstrong S,Göttgens B,Passegué E
11-0341 was used in Flow cytometry/Cell sorting to show that in leukaemia, GMP clusters are constantly produced due to lack of termination cytokines that restore haematopoietic stem-cell quiescence.
Thu Apr 06 00:00:00 EDT 2017
Autophagy maintains the metabolism and function of young and old stem cells.
Nature
Ho TT,Warr MR,Adelman ER,Lansinger OM,Flach J,Verovskaya EV,Figueroa ME,Passegué E
11-0341 was used in Flow cytometry/Cell sorting to demonstrate an essential function for autophagy in removing activated mitochondria and controlling oxidative metabolism, thereby maintaining HSC stemness and regenerative potential.
Thu Mar 09 00:00:00 EST 2017
Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia.
Cancer cell
Reyna DE,Garner TP,Lopez A,Kopp F,Choudhary GS,Sridharan A,Narayanagari SR,Mitchell K,Dong B,Bartholdy BA,Walensky LD,Verma A,Steidl U,Gavathiotis E
11-0341 was used in Flow cytometry/Cell sorting to identify BTSA1, a pharmacologically optimised BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis.
Mon Oct 09 00:00:00 EDT 2017
Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia.
Nature immunology
Fang J,Bolanos LC,Choi K,Liu X,Christie S,Akunuru S,Kumar R,Wang D,Chen X,Greis KD,Stoilov P,Filippi MD,Maciejewski JP,Garcia-Manero G,Weirauch MT,Salomonis N,Geiger H,Zheng Y,Starczynowski DT
11-0341 was used in Flow cytometry/Cell sorting to examine the significance of ubiquitin signalling in coordinating RNA processing by Toll-like receptor pathways during an immune response and in premalignant haematologic diseases.
Wed Feb 01 00:00:00 EST 2017
Lactate dehydrogenase activity drives hair follicle stem cell activation.
Nature cell biology
Flores A,Schell J,Krall AS,Jelinek D,Miranda M,Grigorian M,Braas D,White AC,Zhou JL,Graham NA,Graeber T,Seth P,Evseenko D,Coller HA,Rutter J,Christofk HR,Lowry WE
11-0341-82 was used in Flow cytometry/Cell sorting to suggest that HFSCs maintain a metabolic state that allows them to remain dormant and yet quickly respond to appropriate proliferative stimuli.
Fri Sep 01 00:00:00 EDT 2017
Gli1+ Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target.
Cell stem cell
Schneider RK,Mullally A,Dugourd A,Peisker F,Hoogenboezem R,Van Strien PMH,Bindels EM,Heckl D,Büsche G,Fleck D,Müller-Newen G,Wongboonsin J,Ventura Ferreira M,Puelles VG,Saez-Rodriguez J,Ebert BL,Humphreys BD,Kramann R
11-0341 was used in Flow cytometry/Cell sorting to study the cellular origin of bone marrow fibrosis.
Thu Jun 01 00:00:00 EDT 2017
Hair follicle stem cell cultures reveal self-organizing plasticity of stem cells and their progeny.
The EMBO journal
Chacón-Martínez CA,Klose M,Niemann C,Glauche I,Wickström SA
11-0341 was used in Flow cytometry/Cell sorting to uncovers regulatory dynamics by which phenotypic plasticity of cells drives population-level homeostasis within a niche, and provides a discovery tool for studies on adult stem cell fate.
Tue Jan 17 00:00:00 EST 2017
Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy.
Cancer research
Huang WY,Lai SF,Chiu HY,Chang M,Plikus MV,Chan CC,Chen YT,Tsao PN,Yang TL,Lee HS,Chi P,Lin SJ
11-0341 was used in Flow cytometry/Cell sorting to identify that hair follicles mobilise ectopic progenitors from distinct transit-amplifying cell compartments for regeneration in adaptation to the severity of dystrophy induced by ionising radiation.
Wed Nov 15 00:00:00 EST 2017
Exercise restores muscle stem cell mobilization, regenerative capacity and muscle metabolic alterations via adiponectin/AdipoR1 activation in SAMP10 mice.
Journal of cachexia, sarcopenia and muscle
Inoue A,Cheng XW,Huang Z,Hu L,Kikuchi R,Jiang H,Piao L,Sasaki T,Itakura K,Wu H,Zhao G,Lei Y,Yang G,Zhu E,Li X,Sato K,Koike T,Kuzuya M
11-0341 was used in Flow cytometry/Cell sorting to show that exercise can improve aging-related impairments of BM-derived MuSC regenerative capacity and muscle metabolic alterations via an AMPK-dependent mechanism that is mediated by an adiponectin/AdipoR1 axis in SAMP10 mice.
Thu Jun 01 00:00:00 EDT 2017
Hydrogen-Rich Water Ameliorates Total Body Irradiation-Induced Hematopoietic Stem Cell Injury by Reducing Hydroxyl Radical.
Oxidative medicine and cellular longevity
Zhang J,Xue X,Han X,Li Y,Lu L,Li D,Fan S
11-0341 was used in Flow cytometry/Cell sorting to examine whether consumption of hydrogen-rich water could ameliorate hematopoietic stem cell injury in mice with total body irradiation.
Thu Mar 16 00:00:00 EDT 2017
Human umbilical cord blood-borne fibroblasts contain marrow niche precursors that form a bone/marrow organoid in vivo.
Development (Cambridge, England)
Pievani A,Sacchetti B,Corsi A,Rambaldi B,Donsante S,Scagliotti V,Vergani P,Remoli C,Biondi A,Robey PG,Riminucci M,Serafini M
11-0341 was used in Flow cytometry/Cell sorting to show that human umbilical cord blood-borne fibroblasts are able to recapitulate the conditions by which the bone marrow microenvironment is formed and establish complete hematopoietic stem cell niches.
Wed Mar 15 00:00:00 EDT 2017
A Novel CXCR4 Antagonist CX549 Induces Neuroprotection in Stroke Brain.
Cell transplantation
Wu KJ,Yu SJ,Shia KS,Wu CH,Song JS,Kuan HH,Yeh KC,Chen CT,Bae E,Wang Y
11-0341 was used in Flow cytometry/Cell sorting to characterise the neuroprotective and neurotrophic effect of a novel C-X-C chemokine receptor type 4 antagonist, CX549.
Thu Apr 13 00:00:00 EDT 2017
A Novel CXCR4 Antagonist CX549 Induces Neuroprotection in Stroke Brain.
Cell transplantation
Wu KJ,Yu SJ,Shia KS,Wu CH,Song JS,Kuan HH,Yeh KC,Chen CT,Bae E,Wang Y
11-0341 was used in Flow cytometry/Cell sorting to characterise the neuroprotective and neurotrophic effect of a novel C-X-C chemokine receptor type 4 antagonist, CX549.
Thu Apr 13 00:00:00 EDT 2017
Tissue-engineered sling with adipose-derived stem cells under static mechanical strain.
Experimental and therapeutic medicine
Wang Y,Wang W,Wang X,Wang Y,Wang J,Fu Q,Shi G
11-0341 was used in Flow cytometry/Cell sorting to indicate that adipose-derived stem cells may serve as a source for tissue sling engineering and improve SUI treatments.
Tue Aug 01 00:00:00 EDT 2017
Intravenous Arginine Administration Promotes Proangiogenic Cells Mobilization and Attenuates Lung Injury in Mice with Polymicrobial Sepsis.
Nutrients
Yeh CL,Pai MH,Shih YM,Shih JM,Yeh SL
11-0341 was used in Flow cytometry/Cell sorting to study the potential beneficial effects of intravenous administration of Arginine shortly after the onset of sepsis in mice.
Wed May 17 00:00:00 EDT 2017
Erythro-myeloid progenitors can differentiate from endothelial cells and modulate embryonic vascular remodeling.
Scientific reports
Kasaai B,Caolo V,Peacock HM,Lehoux S,Gomez-Perdiguero E,Luttun A,Jones EA
11034182 was used in immunocytochemistry to show erythro-myeloid progenitors directly differentiate into endothelial cells
Wed Mar 08 00:00:00 EST 2017
Erythro-myeloid progenitors can differentiate from endothelial cells and modulate embryonic vascular remodeling.
Scientific reports
Kasaai B,Caolo V,Peacock HM,Lehoux S,Gomez-Perdiguero E,Luttun A,Jones EA
11034182 was used in immunocytochemistry to show erythro-myeloid progenitors directly differentiate into endothelial cells
Wed Mar 08 00:00:00 EST 2017
Erythro-myeloid progenitors can differentiate from endothelial cells and modulate embryonic vascular remodeling.
Scientific reports
Kasaai B,Caolo V,Peacock HM,Lehoux S,Gomez-Perdiguero E,Luttun A,Jones EA
11034182 was used in immunocytochemistry to show erythro-myeloid progenitors directly differentiate into endothelial cells
Wed Mar 08 00:00:00 EST 2017
Therapeutic efficacy of combined vaccination against tumor pericyte-associated antigens DLK1 and DLK2 in mice.
Oncoimmunology
Fabian KP,Chi-Sabins N,Taylor JL,Fecek R,Weinstein A,Storkus WJ
11-0341-82 was used in Flow cytometry/Cell sorting to show that therapeutic vaccination against DLK1 results in slowed tumour growth, and compensatory expression of DLK2 by tumour-associated pericytes.
Tue Jan 12 00:00:00 EST 2021
Microgrooved-surface topography enhances cellular division and proliferation of mouse bone marrow-derived mesenchymal stem cells.
PloS one
Chaudhary JK,Rath PC
11-0341 was used in Flow cytometry/Cell sorting to assess the benefits of studying mesenchymal stem cell populations in a microgrooved surface-culture compared to standard culture flask-grown cells.
Thu Oct 19 00:00:00 EDT 2017
Tumor-initiating cells of breast and prostate origin show alterations in the expression of genes related to iron metabolism.
Oncotarget
Rychtarcikova Z,Lettlova S,Tomkova V,Korenkova V,Langerova L,Simonova E,Zjablovskaja P,Alberich-Jorda M,Neuzil J,Truksa J
11034182 was used in flow cytometry to find the specific gene signature related to iron metabolism consisting of genes regulating iron uptake, mitochondrial FeS cluster biogenesis and hypoxic response
Tue Jan 24 00:00:00 EST 2017
Rutin-Enriched Extract from Coriandrum sativum L. Ameliorates Ionizing Radiation-Induced Hematopoietic Injury.
International journal of molecular sciences
Han X,Xue X,Zhao Y,Li Y,Liu W,Zhang J,Fan S
11-0341 was used in Flow cytometry/Cell sorting to demonstrate that rutin-enriched coriander extract is able to ameliorate ionising radiation-induced haematopoietic injury partly by reducing ionising radiation-induced oxidative stress.
Sat Apr 29 00:00:00 EDT 2017
Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal.
Nature cell biology
Pietras EM,Mirantes-Barbeito C,Fong S,Loeffler D,Kovtonyuk LV,Zhang S,Lakshminarasimhan R,Chin CP,Techner JM,Will B,Nerlov C,Steidl U,Manz MG,Schroeder T,Passegué E
11-0341 was used in Flow cytometry/Cell sorting to identify a critical regulatory circuit that tailors HSC responses to acute needs, and is likely to underlie deregulated blood homeostasis in chronic inflammation conditions.
Wed Jun 01 00:00:00 EDT 2016
PML-RARA requires DNA methyltransferase 3A to initiate acute promyelocytic leukemia.
The Journal of clinical investigation
Cole CB,Verdoni AM,Ketkar S,Leight ER,Russler-Germain DA,Lamprecht TL,Demeter RT,Magrini V,Ley TJ
11-0341 was used in Flow cytometry/Cell sorting to suggest that PML-RARA requires DNMT3A to initiate acute promyelocytic leukemia in mice.
Fri Jan 01 00:00:00 EST 2016
CD8+ T cells drive autoimmune hematopoietic stem cell dysfunction and bone marrow failure.
Journal of autoimmunity
Gravano DM,Al-Kuhlani M,Davini D,Sanders PD,Manilay JO,Hoyer KK
11-0341 was used in Flow cytometry/Cell sorting to investigate whether CD8+ T cells play a non-redundant role in driving bone marrow failure.
Thu Dec 01 00:00:00 EST 2016
Innate lymphoid cells contribute to allergic airway disease exacerbation by obesity.
The Journal of allergy and clinical immunology
Everaere L,Ait-Yahia S,Molendi-Coste O,Vorng H,Quemener S,LeVu P,Fleury S,Bouchaert E,Fan Y,Duez C,de Nadai P,Staels B,Dombrowicz D,Tsicopoulos A
11-0341 was used in Flow cytometry/Cell sorting to indicate that high-fat diet-induced obesity might exacerbate allergic airway inflammation through mechanisms involving ILC2s and ILC3s.
Tue Nov 01 00:00:00 EDT 2016
Mesenchymal stromal cell-derived extracellular vesicles rescue radiation damage to murine marrow hematopoietic cells.
Leukemia
Wen S,Dooner M,Cheng Y,Papa E,Del Tatto M,Pereira M,Deng Y,Goldberg L,Aliotta J,Chatterjee D,Stewart C,Carpanetto A,Collino F,Bruno S,Camussi G,Quesenberry P
11-0341 was used in Flow cytometry/Cell sorting to evaluate the capacity of mesenchymal stromal cell-derived extracellular vesicles to rescue murine marrow hematopoietic cells damage following exposure to radiation, showing that damage could be reversed using both murine and human MSC-EVs.
Tue Nov 01 00:00:00 EDT 2016
Repression of p53-target gene Bbc3/PUMA by MYSM1 is essential for the survival of hematopoietic multipotent progenitors and contributes to stem cell maintenance.
Cell death and differentiation
Belle JI,Petrov JC,Langlais D,Robert F,Cencic R,Shen S,Pelletier J,Gros P,Nijnik A
11-0341 was used in Flow cytometry/Cell sorting to elucidate the mechanisms underlying the transcriptional activation of p53 stress responses in Mysm1-deficient haematopoietic stem and progenitor cells.
Sun May 01 00:00:00 EDT 2016
Fibrillin-1 microfibrils influence adult bone marrow hematopoiesis.
Matrix biology : journal of the International Society for Matrix Biology
Smaldone S,Bigarella CL,Del Solar M,Ghaffari S,Ramirez F
11-0341 was used in Flow cytometry/Cell sorting to investigate adult haematopoiesis in mice with Cre-mediated inactivation of the fibrillin-1 gene in the mesenchyme of the forming limbs.
Wed Dec 20 00:00:00 EST 2017
The Effect of a BSA Conjugate of a Synthetic Hexasaccharide Related to the Fragment of Capsular Polysaccharide of Streptococcus pneumoniae Type 14 on the Activation of Innate and Adaptive Immune Responses.
Frontiers in immunology
Akhmatova NK,Kurbatova EA,Akhmatov EA,Egorova NB,Logunov DY,Gening ML,Sukhova EV,Yashunsky DV,Tsvetkov YE,Nifantiev NE
11-0341 was used in Flow cytometry/Cell sorting to evaluate the effects of immunisation with a synthetic hexasaccharide conjugate, with and without an adjuvant, on TLR activation, dendritic cell maturation, and cytokine production in mice.
Fri Jul 22 00:00:00 EDT 2016
MMP-25 Metalloprotease Regulates Innate Immune Response through NF-κB Signaling.
Journal of immunology (Baltimore, Md. : 1950)
Soria-Valles C,Gutiérrez-Fernández A,Osorio FG,Carrero D,Ferrando AA,Colado E,Fernández-García MS,Bonzon-Kulichenko E,Vázquez J,Fueyo A,López-Otín C
11-0341 was used in Flow cytometry/Cell sorting to elucidate the in vivo function of matrix metalloprotease-25.
Fri Jul 01 00:00:00 EDT 2016
Treatment of radiation-induced acute intestinal injury with bone marrow-derived mesenchymal stem cells.
Experimental and therapeutic medicine
Zheng K,Wu W,Yang S,Huang L,Chen J,Gong C,Fu Z,Lin R,Tan J
11-0341 was used in Flow cytometry/Cell sorting to identify bone marrow-derived mesenchymal stem cells, whose reparative function can be used to treat radiation-induced acute intestinal injury.
Wed Jun 01 00:00:00 EDT 2016
Mll-AF4 Confers Enhanced Self-Renewal and Lymphoid Potential during a Restricted Window in Development.
Cell reports
Barrett NA,Malouf C,Kapeni C,Bacon WA,Giotopoulos G,Jacobsen SEW,Huntly BJ,Ottersbach K
11-0341 was used in Flow cytometry/Cell sorting to elucidate the contribution of MII-AF4 in B cell acute lymphoblastic leukaemia early development in the mouse embryo.
Tue Jul 26 00:00:00 EDT 2016
A mouse model for a partially inactive obesity-associated human MC3R variant.
Nature communications
Lee B,Koo J,Yun Jun J,Gavrilova O,Lee Y,Seo AY,Taylor-Douglas DC,Adler-Wailes DC,Chen F,Gardner R,Koutzoumis D,Sherafat Kazemzadeh R,Roberson RB,Yanovski JA
11-0341 was used in Flow cytometry/Cell sorting to confirm the importance of MC3R signalling in human metabolism, and suggest a novel role for MC3R in adipose tissue development.
Thu Jan 28 00:00:00 EST 2016
SWEF Proteins Distinctly Control Maintenance and Differentiation of Hematopoietic Stem Cells.
PloS one
Ripich T,Chacón-Martínez CA,Fischer L,Pernis A,Kiessling N,Garbe AI,Jessberger R
11-0341 was used in Flow cytometry/Cell sorting to investigate the role of SWAP-70 and DEF6 in hematopoietic stem and precursor cells.
Mon Jul 31 00:00:00 EDT 2017
Characterization of Cells Isolated from Genetic and Trauma-Induced Heterotopic Ossification.
PloS one
Agarwal S,Drake J,Qureshi AT,Loder S,Li S,Shigemori K,Peterson J,Cholok D,Forsberg JA,Mishina Y,Davis TA,Levi B
11-0341 was used in Flow cytometry/Cell sorting to demonstrate that across models, cells derived from tissues forming heterotopic ossification exhibit increased osteogenic differentiation compared to normal tissues or osteoblasts.
Wed Aug 23 00:00:00 EDT 2017
Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat.
Nature communications
Seki T,Hosaka K,Lim S,Fischer C,Honek J,Yang Y,Andersson P,Nakamura M,Näslund E,Ylä-Herttuala S,Sun M,Iwamoto H,Li X,Liu Y,Samani NJ,Cao Y
11-0341 was used in Flow cytometry/Cell sorting to investigate PDGF-CC regulation of angiogenesis-dependent thermogenesis in beige fat.
Fri Aug 05 00:00:00 EDT 2016
The GIY-YIG Type Endonuclease Ankyrin Repeat and LEM Domain-Containing Protein 1 (ANKLE1) Is Dispensable for Mouse Hematopoiesis.
PloS one
Braun J,Meixner A,Brachner A,Foisner R
11-0341 was used in Flow cytometry/Cell sorting to test whether ANKLE1 may contribute to Holliday junction resolution during DNA repair in mice.
Fri Aug 12 00:00:00 EDT 2016
Clec11a/osteolectin is an osteogenic growth factor that promotes the maintenance of the adult skeleton.
eLife
Yue R,Shen B,Morrison SJ
11-0341 was used in Flow cytometry/Cell sorting to study how Clec11a/Osteolectin maintains the adult skeleton by promoting the differentiation of mesenchymal progenitors into mature osteoblasts.
Tue Dec 13 00:00:00 EST 2016
Alkylator-Induced and Patient-Derived Xenograft Mouse Models of Therapy-Related Myeloid Neoplasms Model Clinical Disease and Suggest the Presence of Multiple Cell Subpopulations with Leukemia Stem Cell Activity.
PloS one
Jonas BA,Johnson C,Gratzinger D,Majeti R
11-0341 was used in Flow cytometry/Cell sorting to report several new t-AML/MDS mouse models that could potentially be used to further define disease pathogenesis and test novel therapeutics.
Wed Jul 26 00:00:00 EDT 2017
miR-29a maintains mouse hematopoietic stem cell self-renewal by regulating Dnmt3a.
Blood
Hu W,Dooley J,Chung SS,Chandramohan D,Cimmino L,Mukherjee S,Mason CE,de Strooper B,Liston A,Park CY
11-0341 was used in Flow cytometry/Cell sorting to demonstrate that miR-29a is critical for maintaining HSC function through its negative regulation of Dnmt3a.
Thu Apr 02 00:00:00 EDT 2015
CD93 Marks a Non-Quiescent Human Leukemia Stem Cell Population and Is Required for Development of MLL-Rearranged Acute Myeloid Leukemia.
Cell stem cell
Iwasaki M,Liedtke M,Gentles AJ,Cleary ML
11-0341 was used in Flow cytometry/Cell sorting to study how CD93 expression may indicate leukaemia initiating stem cells that have a MLL gene rearrangement.
Thu Oct 01 00:00:00 EDT 2015
Function-oriented development of CXCR4 antagonists as selective human immunodeficiency virus (HIV)-1 entry inhibitors.
Journal of medicinal chemistry
Wu CH,Wang CJ,Chang CP,Cheng YC,Song JS,Jan JJ,Chou MC,Ke YY,Ma J,Wong YC,Hsieh TC,Tien YC,Gullen EA,Lo CF,Cheng CY,Liu YW,Sadani AA,Tsai CH,Hsieh HP,Tsou LK,Shia KS
11-0341 was used in Flow cytometry/Cell sorting to identify a CXCR4 antagonist for anti-HIV therapeutics, producing a purine-based antagonist, compound 24, with a subnanomolar EC50 value.
Thu Feb 12 00:00:00 EST 2015
Epidermal keratinocytes initiate wound healing and pro-inflammatory immune responses following percutaneous schistosome infection.
International journal for parasitology
Bourke CD,Prendergast CT,Sanin DE,Oulton TE,Hall RJ,Mountford AP
11-0341 was used in Flow cytometry/Cell sorting to indicate that S.mansoni cercariae and their excretory/secretory products act directly upon epidermal keratinocytes.
Sun Mar 01 00:00:00 EST 2015
High-level Gpr56 expression is dispensable for the maintenance and function of hematopoietic stem and progenitor cells in mice.
Stem cell research
Rao TN,Marks-Bluth J,Sullivan J,Gupta MK,Chandrakanthan V,Fitch SR,Ottersbach K,Jang YC,Piao X,Kulkarni RN,Serwold T,Pimanda JE,Wagers AJ
11-0341 was used in Flow cytometry/Cell sorting to indicate that high-level expression of GPR56 by primitive HSPCs is largely dispensable for steady-state and regenerative hematopoiesis.
Fri May 01 00:00:00 EDT 2015
Sleep disruption impairs haematopoietic stem cell transplantation in mice.
Nature communications
Rolls A,Pang WW,Ibarra I,Colas D,Bonnavion P,Korin B,Heller HC,Weissman IL,de Lecea L
11-0341 was used in Flow cytometry/Cell sorting to provide insights into cellular and molecular mechanisms underlying the effects of sleep deprivation on HSCs.
Wed Oct 14 00:00:00 EDT 2015
Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality.
Nature communications
Alvarez S,Díaz M,Flach J,Rodriguez-Acebes S,López-Contreras AJ,Martínez D,Cañamero M,Fernández-Capetillo O,Isern J,Passegué E,Méndez J
11-0341 was used in Flow cytometry/Cell sorting to determine that haematopoietic progenitors are particularly sensitive to replication stress.
Mon Oct 12 00:00:00 EDT 2015
Loss of IKKβ but Not NF-κB p65 Skews Differentiation towards Myeloid over Erythroid Commitment and Increases Myeloid Progenitor Self-Renewal and Functional Long-Term Hematopoietic Stem Cells.
PloS one
Zhang J,Li L,Baldwin AS,Friedman AD,Paz-Priel I
11-0341 was used in Flow cytometry/Cell sorting to study the effects of IKKβ and NF-κB p65 on hematopoietic lineage commitment and progenitor self-renewal and functional long-term hematopoietic stem cells.
Wed Apr 13 00:00:00 EDT 2016
EphA2 Is a Therapy Target in EphA2-Positive Leukemias but Is Not Essential for Normal Hematopoiesis or Leukemia.
PloS one
Charmsaz S,Beckett K,Smith FM,Bruedigam C,Moore AS,Al-Ejeh F,Lane SW,Boyd AW
11-0341 was used in Flow cytometry/Cell sorting to explore the role of EphA2 in haematopoiesis and leukaemogenesis.
Tue May 03 00:00:00 EDT 2016
Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells.
Nature
Flach J,Bakker ST,Mohrin M,Conroy PC,Pietras EM,Reynaud D,Alvarez S,Diolaiti ME,Ugarte F,Forsberg EC,Le Beau MM,Stohr BA,Méndez J,Morrison CG,Passegué E
11-0341 was used in Flow cytometry/Cell sorting to study functional decline in ageing haematopoietic stem cells due to replicative stress.
Thu Aug 14 00:00:00 EDT 2014
Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancy.
Nature
Nakada D,Oguro H,Levi BP,Ryan N,Kitano A,Saitoh Y,Takeichi M,Wendt GR,Morrison SJ
11-0341 was used in Flow cytometry/Cell sorting to assess the effect of oestradiol administration on division of haematopoietic stem cells in males and females.
Thu Jan 23 00:00:00 EST 2014
Purinergic P2Y₁₄ receptor modulates stress-induced hematopoietic stem/progenitor cell senescence.
The Journal of clinical investigation
Cho J,Yusuf R,Kook S,Attar E,Lee D,Park B,Cheng T,Scadden DT,Lee BC
11-0341 was used in Flow cytometry/Cell sorting to study the role of P2Y14 receptors on stem/progenitor cells in modifying cell senescence and cell death in response to tissue stress.
Tue Jul 01 00:00:00 EDT 2014
Early aberrant DNA methylation events in a mouse model of acute myeloid leukemia.
Genome medicine
Sonnet M,Claus R,Becker N,Zucknick M,Petersen J,Lipka DB,Oakes CC,Andrulis M,Lier A,Milsom MD,Witte T,Gu L,Kim-Wanner SZ,Schirmacher P,Wulfert M,Gattermann N,Lübbert M,Rosenbauer F,Rehli M,Bullinger L,Weichenhan D,Plass C
11-0341 was used in Flow cytometry/Cell sorting to investigate the onset of aberrant DNA methylation events and their dynamics during leukemic progression.
Thu Jun 19 00:00:00 EDT 2014
Autophagy regulates the therapeutic potential of mesenchymal stem cells in experimental autoimmune encephalomyelitis.
Autophagy
Dang S,Xu H,Xu C,Cai W,Li Q,Cheng Y,Jin M,Wang RX,Peng Y,Zhang Y,Wu C,He X,Wan B,Zhang Y
11-0341 was used in Flow cytometry/Cell sorting to study how inflammatory microenvironment-induced autophagy can downregulate the immunosuppressive function of mesenchymal stem cells.
Tue Jul 01 00:00:00 EDT 2014
Microfluidic Isolation of CD34-Positive Skin Cells Enables Regeneration of Hair and Sebaceous Glands In Vivo.
Stem cells translational medicine
Zhu B,Nahmias Y,Yarmush ML,Murthy SK
11-0341 was used in Flow cytometry/Cell sorting to observe the generation of significant levels of hair follicles and sebaceous glands by transplantation of isolated CD34+ cells.
Sat Nov 01 00:00:00 EDT 2014
BMP-non-responsive Sca1+ CD73+ CD44+ mouse bone marrow derived osteoprogenitor cells respond to combination of VEGF and BMP-6 to display enhanced osteoblastic differentiation and ectopic bone formation.
PloS one
Madhu V,Li CJ,Dighe AS,Balian G,Cui Q
11-0341 was used in Flow cytometry/Cell sorting to study how combined action of VEGF and BMP on MSCs enhances osteoblastic differentiation of MSCs and increases their bone forming ability.
Fri Nov 20 00:00:00 EST 2015
Correlated miR-mRNA expression signatures of mouse hematopoietic stem and progenitor cell subsets predict "Stemness" and "Myeloid" interaction networks.
PloS one
Heiser D,Tan YS,Kaplan I,Godsey B,Morisot S,Cheng WC,Small D,Civin CI
11-0341 was used in Flow cytometry/Cell sorting to demonstrate the regulation of intricate haematopoietic networks by miRNAs.
Thu Jan 15 00:00:00 EST 2015
Period2 deficiency blunts hypoxia-induced mobilization and function of endothelial progenitor cells.
PloS one
Qin T,Sun YY,Bai WW,Wang B,Xing YF,Liu Y,Yang RX,Zhao YX,Li JM
11-0341 was used in Flow cytometry/Cell sorting to determine the role of the circadian gene period2 in the regulation of endothelial progenitor cell function after myocardial infarction in mice.
Tue Jun 16 00:00:00 EDT 2015
Discriminating cellular heterogeneity using microwell-based RNA cytometry.
Nature communications
Dimov IK,Lu R,Lee EP,Seita J,Sahoo D,Park SM,Weissman IL,Lee LP
11-0341 was used in Flow cytometry/Cell sorting to develop a two-stage system to determine cellular heterogeneity.
Tue Mar 25 00:00:00 EDT 2014
FOXO3A directs a protective autophagy program in haematopoietic stem cells.
Nature
Warr MR,Binnewies M,Flach J,Reynaud D,Garg T,Malhotra R,Debnath J,Passegué E
11-0341 was used in Flow cytometry/Cell sorting to show how FOXO3A directs a protective autophagy program in haematopoietic stem cells.
Thu Feb 21 00:00:00 EST 2013
Oncogenic Nras has bimodal effects on stem cells that sustainably increase competitiveness.
Nature
Li Q,Bohin N,Wen T,Ng V,Magee J,Chen SC,Shannon K,Morrison SJ
11-0341 was used in Flow cytometry/Cell sorting to show that an allele of oncogenic Nras(G12D) increases not only haematopoietic stem cell proliferation, but also the self-renewal potential to multipotent progenitors.
Thu Dec 05 00:00:00 EST 2013
Xist RNA is a potent suppressor of hematologic cancer in mice.
Cell
Yildirim E,Kirby JE,Brown DE,Mercier FE,Sadreyev RI,Scadden DT,Lee JT
11-0341 was used in Flow cytometry/Cell sorting to demonstrate the interplay between Xist RNA and X chromosome inactivation and their link to tumorigenesis.
Thu Feb 14 00:00:00 EST 2013
HIF prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress.
Blood
Singh RP,Franke K,Kalucka J,Mamlouk S,Muschter A,Gembarska A,Grinenko T,Willam C,Naumann R,Anastassiadis K,Stewart AF,Bornstein S,Chavakis T,Breier G,Waskow C,Wielockx B
11-0341 was used in Flow cytometry/Cell sorting to study the role of PHD2 in HSC compartment maintenance.
Thu Jun 27 00:00:00 EDT 2013
Expression of the secondary granule proteins major basic protein 1 (MBP-1) and eosinophil peroxidase (EPX) is required for eosinophilopoiesis in mice.
Blood
Doyle AD,Jacobsen EA,Ochkur SI,McGarry MP,Shim KG,Nguyen DT,Protheroe C,Colbert D,Kloeber J,Neely J,Shim KP,Dyer KD,Rosenberg HF,Lee JJ,Lee NA
11-0341 was used in Flow cytometry/Cell sorting to investigate the contributions of the granule proteins MBP-1 and EPX to eosinophil activity using double knockout mice.
Thu Aug 01 00:00:00 EDT 2013
Pten loss in the bone marrow leads to G-CSF-mediated HSC mobilization.
The Journal of experimental medicine
Tesio M,Oser GM,Baccelli I,Blanco-Bose W,Wu H,Göthert JR,Kogan SC,Trumpp A
11-0341 was used in Flow cytometry/Cell sorting to investigate the effect of PTEN deletion in bone marrow, showing that it leads to G-CSF-mediated hematopoietic stem cell mobilisation.
Mon Oct 21 00:00:00 EDT 2013
Mast cell-deficient Kit(W-sh) "Sash" mutant mice display aberrant myelopoiesis leading to the accumulation of splenocytes that act as myeloid-derived suppressor cells.
Journal of immunology (Baltimore, Md. : 1950)
Michel A,Schüler A,Friedrich P,Döner F,Bopp T,Radsak M,Hoffmann M,Relle M,Distler U,Kuharev J,Tenzer S,Feyerabend TB,Rodewald HR,Schild H,Schmitt E,Becker M,Stassen M
11-0341 was used in Flow cytometry/Cell sorting to demonstrate the broad effects that the Kit(W-sh) mutation has on key steps in myelopoiesis.
Sat Jun 01 00:00:00 EDT 2013
A non-redundant function of cyclin E1 in hematopoietic stem cells.
Cell cycle (Georgetown, Tex.)
Campaner S,Viale A,De Fazio S,Doni M,De Franco F,D'Artista L,Sardella D,Pelicci PG,Amati B
11-0341 was used in Flow cytometry/Cell sorting to support a role for cyclin E1 in controlling the exit from quiescence in hematopoietic stem cells.
Sun Dec 01 00:00:00 EST 2013
Molecular profiling of single Sca-1+/CD34+,- cells--the putative murine lung stem cells.
PloS one
Hittinger M,Czyz ZT,Huesemann Y,Maneck M,Botteron C,Kaeufl S,Klein CA,Polzer B
11-0341 was used in Flow cytometry/Cell sorting to show that single cell analysis enables the identification of novel molecular markers in yet poorly characterised populations of rare cells.
Thu Sep 18 00:00:00 EDT 2014
IFNγ induces monopoiesis and inhibits neutrophil development during inflammation.
Blood
de Bruin AM,Libregts SF,Valkhof M,Boon L,Touw IP,Nolte MA
11-0341 was used in Flow cytometry/Cell sorting to demonstrate that the pro-inflammatory cytokine IFNγ is involved in orchestrating inflammation-induced myelopoiesis.
Thu Feb 09 00:00:00 EST 2012
Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome.
The Journal of clinical investigation
Malinge S,Bliss-Moreau M,Kirsammer G,Diebold L,Chlon T,Gurbuxani S,Crispino JD
11-0341 was used in Flow cytometry/Cell sorting to show that the calcineurin/NFAT pathway can be both proleukaemic in children and antitumorigenic in adults.
Thu Mar 01 00:00:00 EST 2012
Antibodies and IL-3 support helminth-induced basophil expansion.
Proceedings of the National Academy of Sciences of the United States of America
Herbst T,Esser J,Prati M,Kulagin M,Stettler R,Zaiss MM,Hewitson JP,Merky P,Verbeek JS,Bourquin C,Camberis M,Prout M,Maizels RM,Le Gros G,Harris NL
11-0341 was used in Flow cytometry/Cell sorting to study the support of helminth-induced basophil expansion.
Tue Sep 11 00:00:00 EDT 2012
Biological and clinical availability of adipose-derived stem cells for pelvic dead space repair.
Stem cells translational medicine
Takahashi H,Haraguchi N,Nishikawa S,Miyazaki S,Suzuki Y,Mizushima T,Nishimura J,Takemasa I,Yamamoto H,Mimori K,Ishii H,Doki Y,Mori M
11-0341 was used in Flow cytometry/Cell sorting to clarify the utility of adipose-derived stem cells and resected intraperitoneal fat pads for pelvic cavity repair using a mouse model.
Thu Nov 01 00:00:00 EDT 2012
IL-1β-driven neutrophilia preserves antibacterial defense in the absence of the kinase IKKβ.
Nature immunology
Hsu LC,Enzler T,Seita J,Timmer AM,Lee CY,Lai TY,Yu GY,Lai LC,Temkin V,Sinzig U,Aung T,Nizet V,Weissman IL,Karin M
11-0341 was used in Flow cytometry/Cell sorting to observe neutrophilia in mice with an inducible deletion of IKKβ (Ikkβ(δ) mice) which is believed to be critical for innate immunity.
Tue Feb 01 00:00:00 EST 2011
Chronic IFN-γ production in mice induces anemia by reducing erythrocyte life span and inhibiting erythropoiesis through an IRF-1/PU.1 axis.
Blood
Libregts SF,Gutiérrez L,de Bruin AM,Wensveen FM,Papadopoulos P,van Ijcken W,Ozgür Z,Philipsen S,Nolte MA
11-0341 was used in Flow cytometry/Cell sorting to reveal a molecular mechanism by which chronic exposure to IFN-γ induces expression of IRF-1 and ultimately induces anaemia.
Thu Sep 01 00:00:00 EDT 2011
Angiopoietin-1 promotes endothelial differentiation from embryonic stem cells and induced pluripotent stem cells.
Blood
Joo HJ,Kim H,Park SW,Cho HJ,Kim HS,Lim DS,Chung HM,Kim I,Han YM,Koh GY
11-0341 was used in Flow cytometry/Cell sorting to study the role of Ang1/Tie2 signalling in ESC differentiation.
Thu Aug 25 00:00:00 EDT 2011
Deletion of tristetraprolin caused spontaneous reactive granulopoiesis by a non-cell-autonomous mechanism without disturbing long-term hematopoietic stem cell quiescence.
Journal of immunology (Baltimore, Md. : 1950)
Kaplan IM,Morisot S,Heiser D,Cheng WC,Kim MJ,Civin CI
11-0341 was used in Flow cytometry/Cell sorting to characterise hematopoiesis in TTP KO mice to show that TTP is a master regulator of inflammatory cytokine expression during homeostasis that controls granulocyte production.
Tue Mar 01 00:00:00 EST 2011
Identification of a novel antigen cross-presenting cell type in spleen.
Journal of cellular and molecular medicine
Tan JK,Quah BJ,Griffiths KL,Periasamy P,Hey YY,O'Neill HC
11-0341 was used in Flow cytometry/Cell sorting to study a novel DC type produced by in vitro haematopoiesis which has distinct antigen-presenting potential and reflects a DC subset present also in vivo in spleen.
Sun May 01 00:00:00 EDT 2011
The transcriptional coactivator Cbp regulates self-renewal and differentiation in adult hematopoietic stem cells.
Molecular and cellular biology
Chan WI,Hannah RL,Dawson MA,Pridans C,Foster D,Joshi A,Göttgens B,Van Deursen JM,Huntly BJ
11-0341 was used in Flow cytometry/Cell sorting to investigate the role of Cbp in adult HSC maintenance, and the cellular and molecular mechanisms underlying its function.
Thu Dec 01 00:00:00 EST 2011
Heparan sulfate regulates VEGF165- and VEGF121-mediated vascular hyperpermeability.
The Journal of biological chemistry
Xu D,Fuster MM,Lawrence R,Esko JD
11-0341 was used in Flow cytometry/Cell sorting to demonstrate how VEGF-induced vascular hyper-permeability depends on endothelial heparan sulfate.
Fri Jan 07 00:00:00 EST 2011
Expression and role of FLT3 in regulation of the earliest stage of normal granulocyte-monocyte progenitor development.
Blood
Böiers C,Buza-Vidas N,Jensen CT,Pronk CJ,Kharazi S,Wittmann L,Sitnicka E,Hultquist A,Jacobsen SE
11-0341 was used in Flow cytometry/Cell sorting to investigate the role of FLT3 in early granulocyte-monocyte progenitors (GMPs), showing that most GMPs are derived from FLT3-expressing progenitors.
Thu Jun 17 00:00:00 EDT 2010
MCP1 directs trafficking of hematopoietic stem cell-derived fibroblast precursors in solid tumor.
The American journal of pathology
Abangan RS,Williams CR,Mehrotra M,Duncan JD,Larue AC
11-0341 was used in Flow cytometry/Cell sorting to investigate the mechanisms regulating recruitment and homing of HSC-derived carcinoma-associated fibroblasts to the tumour microenvironment, showing that MCP1 directs trafficking.
Thu Apr 01 00:00:00 EDT 2010
Additive and global functions of HoxA cluster genes in mesoderm derivatives.
Developmental biology
Di-Poï N,Koch U,Radtke F,Duboule D
11-0341 was used in Flow cytometry/Cell sorting to report that mutant mice lacking the entire HoxA cluster in mesodermal lineages display the expected spectrum of postnatal respiratory, cardiac and urogenital defects, previously reported for single gene mutations.
Sat May 15 00:00:00 EDT 2010
Postobstructive regeneration of kidney is derailed when surge in renal stem cells during course of unilateral ureteral obstruction is halted.
American journal of physiology. Renal physiology
Park HC,Yasuda K,Ratliff B,Stoessel A,Sharkovska Y,Yamamoto I,Jasmin JF,Bachmann S,Lisanti MP,Chander P,Goligorsky MS
11-0341 was used in Flow cytometry/Cell sorting to demonstrate that the surge in stem cell accumulation during unilateral ureteral obstruction is a prerequisite for regeneration of renal parenchyma.
Mon Feb 01 00:00:00 EST 2010
Enhanced progenitor cell recruitment and endothelial repair after selective endothelial injury of the mouse kidney.
American journal of physiology. Renal physiology
Hohenstein B,Kuo MC,Addabbo F,Yasuda K,Ratliff B,Schwarzenberger C,Eckardt KU,Hugo CP,Goligorsky MS
11-0341 was used in Flow cytometry/Cell sorting to present the time-course of HSC and EPC homing after renal endothelial injury, and the angiogenic factors that might influence the repair response.
Tue Jun 01 00:00:00 EDT 2010
Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia.
Blood
Guibal FC,Alberich-Jorda M,Hirai H,Ebralidze A,Levantini E,Di Ruscio A,Zhang P,Santana-Lemos BA,Neuberg D,Wagers AJ,Rego EM,Tenen DG
11-0341 was used in Flow cytometry/Cell sorting to provide further understanding of the biology of APL by demonstrating that a committed transformed progenitor can propagate the disease.
Thu Dec 24 00:00:00 EST 2009
Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells.
Cancer research
Santisteban M,Reiman JM,Asiedu MK,Behrens MD,Nassar A,Kalli KR,Haluska P,Ingle JN,Hartmann LC,Manjili MH,Radisky DC,Ferrone S,Knutson KL
11-0341 was used in Flow cytometry/Cell sorting to show that epithelial to mesenchymal transition can produce the breast cancer stem cell phenotype.
Wed Apr 01 00:00:00 EDT 2009
Adenoviral transfer of HIF-1alpha enhances vascular responses to critical limb ischemia in diabetic mice.
Proceedings of the National Academy of Sciences of the United States of America
Sarkar K,Fox-Talbot K,Steenbergen C,Bosch-Marcé M,Semenza GL
11-0341 was used in Flow cytometry/Cell sorting to evaluate the therapeutic potential of AdCA5, an adenovirus encoding a constitutively active form of HIF-1alpha, in a diabetic model of critical limb ischemia.
Tue Nov 03 00:00:00 EST 2009
Nox2-containing NADPH oxidase deficiency confers protection from hindlimb ischemia in conditions of increased oxidative stress.
Arteriosclerosis, thrombosis, and vascular biology
Haddad P,Dussault S,Groleau J,Turgeon J,Michaud SE,Ménard C,Perez G,Maingrette F,Rivard A
11-0341 was used in Flow cytometry/Cell sorting to investigate the role for Nox2-containing NADPH oxidase in the modulation of neovascularisation in conditions of increased oxidative stress.
Thu Oct 01 00:00:00 EDT 2009
A subpopulation of mesenchymal stromal cells with high osteogenic potential.
Journal of cellular and molecular medicine
Liu H,Toh WS,Lu K,MacAry PA,Kemeny DM,Cao T
11-0341 was used in Flow cytometry/Cell sorting to identify and isolate a sub-population of murine mesenchymal stem cells at an early passage number with high osteogenic potential.
Sat Aug 01 00:00:00 EDT 2009
Identification of regulatory functions for 4-1BB and 4-1BBL in myelopoiesis and the development of dendritic cells.
Nature immunology
Lee SW,Park Y,So T,Kwon BS,Cheroutre H,Mittler RS,Croft M
11-0341 was used in Flow cytometry/Cell sorting to show that the costimulatory molecule 4-1BB, and also its ligand 4-1BBL, is able to limit myelopoiesis and dendritic cell development.
Fri Aug 01 00:00:00 EDT 2008
Ischemia-induced exocytosis of Weibel-Palade bodies mobilizes stem cells.
Journal of the American Society of Nephrology : JASN
Kuo MC,Patschan D,Patschan S,Cohen-Gould L,Park HC,Ni J,Addabbo F,Goligorsky MS
11-0341 was used in Flow cytometry/Cell sorting to suggest that exocytosis of Weibel-Palade bodies links postischemic repair with inflammation and mobilisation of stem cells.
Mon Dec 01 00:00:00 EST 2008
Vaccinia virus infection modulates the hematopoietic cell compartments in the bone marrow.
Stem cells (Dayton, Ohio)
Singh P,Yao Y,Weliver A,Broxmeyer HE,Hong SC,Chang CH
Tue Apr 01 00:00:00 EDT 2008
E47 controls the developmental integrity and cell cycle quiescence of multipotential hematopoietic progenitors.
Journal of immunology (Baltimore, Md. : 1950)
Yang Q,Kardava L,St Leger A,Martincic K,Varnum-Finney B,Bernstein ID,Milcarek C,Borghesi L
11-0341 was used in Flow cytometry/Cell sorting to show E47 controls the developmental integrity and cell cycle quiescence of hematopoietic progenitors.
Sat Nov 01 00:00:00 EDT 2008
The CB(2) cannabinoid receptor controls myeloid progenitor trafficking: involvement in the pathogenesis of an animal model of multiple sclerosis.
The Journal of biological chemistry
Palazuelos J,Davoust N,Julien B,Hatterer E,Aguado T,Mechoulam R,Benito C,Romero J,Silva A,Guzmán M,Nataf S,Galve-Roperh I
Fri May 09 00:00:00 EDT 2008
Stable form of JAB1 enhances proliferation and maintenance of hematopoietic progenitors.
The Journal of biological chemistry
Mori M,Yoneda-Kato N,Yoshida A,Kato JY
11-0341 was used in Flow cytometry/Cell sorting to investigate how the expression and function of JAB1 are critical for the proliferation and maintenance of hematopoietic progenitors.
Fri Oct 24 00:00:00 EDT 2008
Hair cycle-dependent changes of alkaline phosphatase activity in the mesenchyme and epithelium in mouse vibrissal follicles.
Development, growth & differentiation
Iida M,Ihara S,Matsuzaki T
Sun Apr 01 00:00:00 EDT 2007
The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages.
Genes & development
Iwasaki H,Mizuno S,Arinobu Y,Ozawa H,Mori Y,Shigematsu H,Takatsu K,Tenen DG,Akashi K
11-0341 was used in Flow cytometry/Cell sorting to show that the expression timing of GATA-2 and CCAAT enhancer-binding protein alpha can differentially control their lineage commitment.
Wed Nov 01 00:00:00 EST 2006
Adult mouse hematopoietic stem cells: purification and single-cell assays.
Nature protocols
Ema H,Morita Y,Yamazaki S,Matsubara A,Seita J,Tadokoro Y,Kondo H,Takano H,Nakauchi H
Mon Nov 05 00:00:00 EST 2007
