Invitrogen

CD11b Monoclonal Antibody (M1/70), eBioscience™

Advanced Verification

This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.

94 Published Figures

678 References

View all (223) CD11b antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

CD11b Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 98

CD11b Antibody (14-0112-82) in IHC (P)

Immunohistochemical analysis of CD11b was performed using formalin-fixed paraffin-embedded mouse spleen tissue sections. To expose the target protein, heat-induced epitope retrieval was performed on de-paraffinized sections using eBioscience™ IHC Antigen Retrieval Solution - Low pH (10X) (Product # 00-4955-58) diluted to 1X solution in water in a decloaking chamber at 110 degree Celsius for 15 minutes. Foll... View More

CD11b Antibody in Immunohistochemistry (IHC)

CD11b Antibody in Immunocytochemistry (ICC/IF)

CD11b Antibody in Immunocytochemistry, Immunohistochemistry (PFA fixed) (ICC/IF, IHC (PFA))

CD11b Antibody in Immunohistochemistry (Frozen) (IHC (F))

CD11b Antibody in Immunohistochemistry, Flow Cytometry (IHC, Flow)

CD11b Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

Product Image Gallery

CD11b Antibody — Figure 5 Microglial activation in whole-mount retina and microglial migration in an in vitro model. (A) Microglia in wild-type (WT) retina have a different shape from those in the trif-/- group as shown by CD11b immunostaining at 7 and 14 days post-crush (7dPC and 14dPC). Scale bar = 20 µm. (B) Estimated numbers of microglia/mm2 in whole-mount retinas were different between different time-course groups (*P < 0.05 increase relative to sham and 14dPC group). (C) Estimated number per mm2 of microglia with an amoeboid shape in whole-mount retinas were different between wild-type (WT and trif-/- groups at 7 and 14 days post-crush (7dPC and 14dPC). *P < 0.01 increase relative to WT group in 7dPC and 14dPC. (D) Outline of whole-mount retina. Square frames (red) were counted using double-blinded quantification. (E) In a transwell system, microglia and retinal ganglion cells (RGCs) were cultured together (as shown in drawing). Microglia became activated and migrated to the other side of the membrane when stimulated by injured RGCs in the lower well. Stained with cresyl violet acetate. Scale bar = 20 µm. {TM}

Product Details

14-0112-82

Applications

Tested Dilution

Publications

Western Blot (WB)

View 3 publications 3 publications

Immunohistochemistry (IHC)

View 63 publications 63 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100

View 1 publication 1 publication

Immunohistochemistry (PFA fixed) (IHC (PFA))

View 5 publications 5 publications

Immunohistochemistry (Frozen) (IHC (F))

View 10 publications 10 publications

Immunocytochemistry (ICC/IF)

View 35 publications 35 publications

Flow Cytometry (Flow)

0.25 µg/test

View 538 publications 538 publications

ELISA (ELISA)

View 1 publication 1 publication

Immunoprecipitation (IP)

Assay-Dependent

View 2 publications 2 publications

Neutralization (Neu)

Assay-Dependent

View 7 publications 7 publications

Functional Assay (Functional)

Assay-Dependent

View 3 publications 3 publications

Inhibition Assays (IA)

View 1 publication 1 publication

In vitro Assay (IV)

View 2 publications 2 publications

Miscellaneous PubMed (Misc)

View 7 publications 7 publications

Product Specifications

Species Reactivity

Mouse

Published species

Bat, Fish, Human, Mouse, Rabbit

Host/Isotype

Rat / IgG2b, kappa

Class

Monoclonal

Type

Antibody

Clone

M1/70

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4° C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_467108

Product Specific Information

Description: The M1/70 monoclonal antibody reacts with mouse CD11b, the 165-170 kDa integrin alphaM. CD11b non-covalently associates with CD18 to form alphaMbeta2 integrin (Mac-1) and binds to CD54 (ICAM-1), C3bi, and fibrinogen. Mac-1 is expressed by macrophages, NK cells, granulocytes, activated lymphocytes and mouse B-1 cells in the peritoneal cavity. M1/70 is also cross-reactive to human CD11b, and can be used for the detection of this antigen on human peripheral blood monocytes, granulocytes, and a subset of NK cells. Through interactions with its ligands, CD11b participates in adhesive cell interactions.

Applications Reported: The M1/70 antibody has been reported for use in flow cytometric analysis, immunoprecipitation, and immunohistochemical staining of frozen tissue. The M1/70 clone is not recommended for immunohistochemical staining of formalin-fixed paraffin embedded tissue. M1/70 has also been reported in in vitro blocking of CD11b function. (Please use Functional Grade purified M1/70, Product # 16-0112, in functional assays).

Applications Tested: The M1/70 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.25 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Purity: Greater than 90%, as determined by SDS-PAGE.

Aggregation: Less than 10%, as determined by HPLC.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that associates non-covalently with integrin beta-2 (CD18). The CD11b/CD18 heterodimeric complex is also known as integrin alpha-M beta-2, Mac-1, and CR3 (complement receptor 3). CD11b is expressed on the surface of monocytes/macrophages, granulocytes, activated lymphocytes, a subset of NK cells, a subset of dendritic cells, and microglia in the brain. CD11b/CD18 functions as the receptor for ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), CD14, CD50, CD23, heparin, iC3b, fibrinogen, and Factor X -these adhesions are critical for cell-cell and cell-matrix interactions. CD11b is expressed on 8% of spleen cells, 44% of bone marrow cells, and less than 1% of thymocytes, and is commonly used as a microglial marker in nervous tissue. The expression of CD11b increases during monocyte maturation and expression levels vary on tissue macrophages. Further, peritoneal macrophages are reported to express higher levels of CD11b than splenic macrophages. Diseases associated with CD11b dysfunction include systemic lupus erythematosus 6 and ITGAM-related susceptibility to systemic lupus erythematosus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Deciphering the mechanism of Peptostreptococcus anaerobius-induced chemoresistance in colorectal cancer: the important roles of MDSC recruitment and EMT activation.

Frontiers in immunology

Gu J,Lv X,Li W,Li G,He X,Zhang Y,Shi L,Zhang X

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Oct 03 00:00:00 EDT 2023

Exogenous IL-10 posttreatment along with TLR4 and TNFR1 blockade improves tissue antioxidant status by modulating sepsis-induced macrophage polarization.

Journal of applied toxicology : JAT

Sawoo R,Dey R,Ghosh R,Bishayi B

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Sun Oct 01 00:00:00 EDT 2023

Gene deletion of long-chain acyl-CoA synthetase 4 attenuates xenobiotic chemical-induced lung injury via the suppression of lipid peroxidation.

Redox biology

Tomitsuka Y,Imaeda H,Ito H,Asou I,Ohbayashi M,Ishikawa F,Kuwata H,Hara S

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Sun Oct 01 00:00:00 EDT 2023

Intranasal Delivery of Endothelial Cell-Derived Extracellular Vesicles with Supramolecular Gel Attenuates Myocardial Ischemia-Reperfusion Injury.

International journal of nanomedicine

Wang J,Tan Y,Dai Y,Hu K,Tan X,Jiang S,Li G,Zhang X,Kang L,Wang X,Xu B

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu Oct 05 00:00:00 EDT 2023

The Cxcr2⁺ subset of the S100a8⁺ gastric granylocytic myeloid-derived suppressor cell population (G-MDSC) regulates gastric pathology.

Frontiers in immunology

Kao KD,Grasberger H,El-Zaatari M

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Fri Sep 29 00:00:00 EDT 2023

Targeting adrenergic receptors to mitigate invariant natural killer T cells-induced acute liver injury.

iScience

Gonzatti MB,Freire BM,Antunes MM,de Menezes GB,Talbot J,Peron JPS,Basso AS,Keller AC

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Fri Oct 20 00:00:00 EDT 2023

Perinatal murine cytomegalovirus infection reshapes the transcriptional profile and functionality of NK cells.

Nature communications

Rožmanić C,Lisnić B,Pribanić Matešić M,Mihalić A,Hiršl L,Park E,Lesac Brizić A,Indenbirken D,Viduka I,Šantić M,Adler B,Yokoyama WM,Krmpotić A,Juranić Lisnić V,Jonjić S,Brizić I

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu Oct 12 00:00:00 EDT 2023

LAL deficiency induced myeloid-derived suppressor cells as targets and biomarkers for lung cancer.

Journal for immunotherapy of cancer

Zhao T,Liu S,Hanna NH,Jalal S,Ding X,Wan J,Yan C,Du H

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2023

Chronic psychological stress promotes breast cancer pre-metastatic niche formation by mobilizing splenic MDSCs via TAM/CXCL1 signaling.

Journal of experimental & clinical cancer research : CR

Zheng Y,Wang N,Wang S,Zhang J,Yang B,Wang Z

14-0112-82 was used in Immunohistochemistry-immunofluorescence to investigate the impact of chronic psychological stress on breast cancer growth, metastasis, and pre-metastatic niche (PMN) formation.

Sat May 20 00:00:00 EDT 2023

Pharmacological potential of Withania somnifera (L.) Dunal and Tinospora cordifolia (Willd.) Miers on the experimental models of COVID-19, T cell differentiation, and neutrophil functions.

Frontiers in immunology

Rizvi ZA,Babele P,Madan U,Sadhu S,Tripathy MR,Goswami S,Mani S,Dikshit M,Awasthi A

14-0112-82 was used in In vitro Assay to demonstrate a robust protective effect of WS against COVID-19 through its broader immunomodulatory activity.

Mon Mar 27 00:00:00 EDT 2023

Topical Diacerein Decreases Skin and Splenic CD11c⁺ Dendritic Cells in Psoriasis.

International journal of molecular sciences

Brunner SM,Ramspacher A,Rieser C,Leitner J,Heil H,Ablinger M,Tevini J,Wimmer M,Koller A,Piñón Hofbauer J,Felder TK,Bauer JW,Kofler B,Lang R,Wally V

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Feb 21 00:00:00 EST 2023

CD11c⁺ microglia promote white matter repair after ischemic stroke.

Cell death & disease

Jia J,Zheng L,Ye L,Chen J,Shu S,Xu S,Bao X,Xia S,Liu R,Xu Y,Zhang M

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Fri Feb 24 00:00:00 EST 2023

Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Zhang Y,Liu T,Deng Z,Fang W,Zhang X,Zhang S,Wang M,Luo S,Meng Z,Liu J,Sukhova GK,Li D,McKenzie ANJ,Libby P,Shi GP,Guo J

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2023

Anti-PD-L1 antibody enhances curative effect of cryoablation via antibody-dependent cell-mediated cytotoxicity mediating PD-L1^highCD11b⁺ cells elimination in hepatocellular carcinoma.

Acta pharmaceutica Sinica. B

Tan J,Liu T,Fan W,Wei J,Zhu B,Liu Y,Liu L,Zhang X,Chen S,Lin H,Zhang Y,Li J

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Wed Feb 01 00:00:00 EST 2023

Oxygen-carrying nanoplatform to reprogram tumor immunosuppressive microenvironment and enhance photothermal-immunotherapy.

Materials today. Bio

Huang J,Leng X,Jiang T,Xu L,Zheng J,Fang M,Wang J,Wang Z,Zhang L

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Sat Apr 01 00:00:00 EDT 2023

Non-Oncogene Addiction of KRAS-Mutant Cancers to IL-1β via Versican and Mononuclear IKKβ.

Cancers

Spella M,Ntaliarda G,Skiadas G,Lamort AS,Vreka M,Marazioti A,Lilis I,Bouloukou E,Giotopoulou GA,Pepe MAA,Weiss SAI,Petrera A,Hauck SM,Koch I,Lindner M,Hatz RA,Behr J,Arendt KAM,Giopanou I,Brunn D,Savai R,Jenne DE,de Château M,Yull FE,Blackwell TS,Stathopoulos GT

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Mon Mar 20 00:00:00 EDT 2023

Monocytes reprogrammed by tumor microparticle vaccine inhibit tumorigenesis and tumor development.

Cancer nanotechnology

Sun W,Dai L,Cao Y,Pan P,Zhi L,Wang X,Yuan X,Gao Z,Guo S,Liu G,Yin J,Xie L,Wang L,Wang Y,Li W,Li H,Jia Y

14-0112-82 was used in Flow cytometry/Cell sorting to provide novel vaccination strategy for the development of tumor vaccines and facilitate the application of T-MPs for clinic oncotherapy.

Tue Apr 25 00:00:00 EDT 2023

The polarization of microglia and infiltrated macrophages in the injured mice spinal cords: a dynamic analysis.

PeerJ

Li JL,Fu GQ,Wang YY,Bian MM,Xu YM,Zhang L,Chen YQ,Zhang N,Ding SQ,Wang R,Fang R,Tang J,Hu JG,Lü HZ

14-0112-82 was used in Flow Cytometry, Functional Assay, Immunohistochemistry (Paraffin), Immunoprecipitation, Neutralization to study if M1 cells in injured spinal cords were mainly derived from MG rather than infiltrating Mø.

Tue Feb 28 00:00:00 EST 2023

Metabolic improvement and liver regeneration by inhibiting CXXC5 function for non-alcoholic steatohepatitis treatment.

Experimental & molecular medicine

Seo SH,Kim E,Yoon M,Lee SH,Park BH,Choi KY

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu Sep 01 00:00:00 EDT 2022

Macrophages in epididymal adipose tissue secrete osteopontin to regulate bone homeostasis.

Nature communications

Dai B,Xu J,Li X,Huang L,Hopkins C,Wang H,Yao H,Mi J,Zheng L,Wang J,Tong W,Chow DH,Li Y,He X,Hu P,Chen Z,Zu H,Li Y,Yao Y,Jiang Q,Qin L

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu Jan 20 00:00:00 EST 2022

PI3Kγ stimulates a high molecular weight form of myosin light chain kinase to promote myeloid cell adhesion and tumor inflammation.

Nature communications

Schmid MC,Kang SW,Chen H,Paradise M,Ghebremedhin A,Kaneda MM,Chin SM,Do A,Watterson DM,Varner JA

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Fri Apr 01 00:00:00 EDT 2022

Neutrophil-dendritic cell interaction plays an important role in live attenuated Leishmania vaccine induced immunity.

PLoS neglected tropical diseases

Bhattacharya P,Ismail N,Saxena A,Gannavaram S,Dey R,Oljuskin T,Akue A,Takeda K,Yu J,Karmakar S,Dagur PK,McCoy JP,Nakhasi HL

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Feb 01 00:00:00 EST 2022

Influence of the Postmortem/Storage Time of Human Corneas on the Properties of Cultured Limbal Epithelial Cells.

Cells

Le-Bel G,Desjardins P,Gross C,Cortez Ghio S,Couture C,Germain L,Guérin SL

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Western Blot

Wed Aug 31 00:00:00 EDT 2022

TIM3 Expression in Anaplastic-Thyroid-Cancer-Infiltrating Macrophages: An Emerging Immunotherapeutic Target.

Biology

Palacios LM,Peyret V,Viano ME,Geysels RC,Chocobar YA,Volpini X,Pellizas CG,Nicola JP,Motran CC,Rodriguez-Galan MC,Fozzatti L

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu Nov 03 00:00:00 EDT 2022

Comparative analysis of thoracic and abdominal aortic aneurysms across the segment and species at the single-cell level.

Frontiers in pharmacology

Wu H,Xie C,Wang R,Cheng J,Xu Q,Zhao H

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu Feb 02 00:00:00 EST 2023

Microglial angiotensin type 2 receptors mediate sex-specific expression of inflammatory cytokines independently of circulating estrogen.

Glia

Garrido-Gil P,Pedrosa MA,Garcia-Garrote M,Pequeño-Valtierra A,Rodríguez-Castro J,García-Souto D,Rodríguez-Pérez AI,Labandeira-Garcia JL

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu Dec 01 00:00:00 EST 2022

Single-cell transcriptomics reveals distinct cell response between acute and chronic pulmonary infection of Pseudomonas aeruginosa.

MedComm

Hu X,Wu M,Ma T,Zhang Y,Zou C,Wang R,Zhang Y,Ren Y,Li Q,Liu H,Li H,Wang T,Sun X,Yang Y,Tang M,Li X,Li J,Gao X,Li T,Zhou X

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunohistochemistry

Thu Dec 01 00:00:00 EST 2022

Single-cell transcriptomics reveals distinct cell response between acute and chronic pulmonary infection of Pseudomonas aeruginosa.

MedComm

Hu X,Wu M,Ma T,Zhang Y,Zou C,Wang R,Zhang Y,Ren Y,Li Q,Liu H,Li H,Wang T,Sun X,Yang Y,Tang M,Li X,Li J,Gao X,Li T,Zhou X

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunohistochemistry

Thu Dec 01 00:00:00 EST 2022

Regulation of chromatin accessibility by the histone chaperone CAF-1 sustains lineage fidelity.

Nature communications

Franklin R,Guo Y,He S,Chen M,Ji F,Zhou X,Frankhouser D,Do BT,Chiem C,Jang M,Blanco MA,Vander Heiden MG,Rockne RC,Ninova M,Sykes DB,Hochedlinger K,Lu R,Sadreyev RI,Murn J,Volk A,Cheloufi S

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Fri Apr 29 00:00:00 EDT 2022

Biocompatible reduced graphene oxide stimulated BMSCs induce acceleration of bone remodeling and orthodontic tooth movement through promotion on osteoclastogenesis and angiogenesis.

Bioactive materials

Jiao D,Wang J,Yu W,Zhang K,Zhang N,Cao L,Jiang X,Bai Y

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu Sep 01 00:00:00 EDT 2022

Clinicopathological Features of Gastric Cancer with Autoimmune Gastritis.

Biomedicines

Arai J,Niikura R,Hayakawa Y,Suzuki N,Hirata Y,Ushiku T,Fujishiro M

14-0112-82 was used in Immunohistochemistry to identify molecular differences between AIG and non-AIG gastric cancer.

Tue Apr 12 00:00:00 EDT 2022

Epigenetic Studies in the Male APP/BIN1/COPS5 Triple-Transgenic Mouse Model of Alzheimer's Disease.

International journal of molecular sciences

Martínez-Iglesias O,Naidoo V,Carrera I,Cacabelos R

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunohistochemistry

Wed Feb 23 00:00:00 EST 2022

Epigenetic Studies in the Male APP/BIN1/COPS5 Triple-Transgenic Mouse Model of Alzheimer's Disease.

International journal of molecular sciences

Martínez-Iglesias O,Naidoo V,Carrera I,Cacabelos R

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunohistochemistry

Wed Feb 23 00:00:00 EST 2022

Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19.

Cell host & microbe

Guo Q,Zhao Y,Li J,Liu J,Yang X,Guo X,Kuang M,Xia H,Zhang Z,Cao L,Luo Y,Bao L,Wang X,Wei X,Deng W,Wang N,Chen L,Chen J,Zhu H,Gao R,Qin C,Wang X,You F

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Wed Feb 10 00:00:00 EST 2021

Mice with a specific deficiency of Pfkfb3 in myeloid cells are protected from hypoxia-induced pulmonary hypertension.

British journal of pharmacology

Wang L,Zhang X,Cao Y,Ma Q,Mao X,Xu J,Yang Q,Zhou Y,Lucas R,Fulton DJ,Su Y,Barman SA,Hong M,Liu Z,Huo Y

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Mon Mar 01 00:00:00 EST 2021

Depletion of Adipocyte Becn1 Leads to Lipodystrophy and Metabolic Dysregulation.

Diabetes

Jin Y,Ji Y,Song Y,Choe SS,Jeon YG,Na H,Nam TW,Kim HJ,Nahmgoong H,Kim SM,Kim JW,Nam KT,Seong JK,Hwang D,Park CB,Lee IH,Kim JB,Lee HW

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunohistochemistry

Fri Jan 01 00:00:00 EST 2021

The effects of postmortem delay on mouse and human microglia gene expression.

Glia

Heng Y,Dubbelaar ML,Marie SKN,Boddeke EWGM,Eggen BJL

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu Apr 01 00:00:00 EDT 2021

Intrinsic DNA damage repair deficiency results in progressive microglia loss and replacement.

Glia

Zhang X,Heng Y,Kooistra SM,van Weering HRJ,Brummer ML,Gerrits E,Wesseling EM,Brouwer N,Nijboer TW,Dubbelaar ML,Boddeke EWGM,Eggen BJL

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Mon Mar 01 00:00:00 EST 2021

CD36 deficiency ameliorates drug-induced acute liver injury in mice.

Molecular medicine (Cambridge, Mass.)

Zhang C,Shi X,Su Z,Hu C,Mu X,Pan J,Li M,Teng F,Ling T,Zhao T,Xu C,Ji G,You Q

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Sun Jun 06 00:00:00 EDT 2021

Eliminating mesothelioma by AAV-vectored, PD1-based vaccination in the tumor microenvironment.

Molecular therapy oncolytics

Tan Z,Chiu MS,Yan CW,Man K,Chen Z

14-0112-82 was used in Flow Cytometry to evaluate the potential of recombinant adeno-associated virus (rAAV)-vectored, PD1-based vaccination in the tumor microenvironment (TME) to activate antigen-specific T cell responses in the immune-competent murine mesothelioma model.

Fri Mar 26 00:00:00 EDT 2021

VX-765 reduces neuroinflammation after spinal cord injury in mice.

Neural regeneration research

Chen J,Chen YQ,Shi YJ,Ding SQ,Shen L,Wang R,Wang QY,Zha C,Ding H,Hu JG,Lü HZ

14-0112-82 was used in Immunohistochemistry to suggest that VX-765 can reduce neuroinflammation and improve nerve function recovery after spinal cord injury by inhibiting caspase-1/interleukin-1β/interleukin-18.

Wed Sep 01 00:00:00 EDT 2021

Light Environment Influences Developmental Programming of the Metabolic and Visual Systems in Mice.

Investigative ophthalmology & visual science

Clarkson-Townsend DA,Bales KL,Marsit CJ,Pardue MT

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunohistochemistry

Thu Apr 01 00:00:00 EDT 2021

Light Environment Influences Developmental Programming of the Metabolic and Visual Systems in Mice.

Investigative ophthalmology & visual science

Clarkson-Townsend DA,Bales KL,Marsit CJ,Pardue MT

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunohistochemistry

Thu Apr 01 00:00:00 EDT 2021

Advanced maternal age induces fetal growth restriction through decreased placental inflammatory cytokine expression and immune cell accumulation in mice.

The Journal of reproduction and development

Hirata Y,Katsukura Y,Henmi Y,Ozawa R,Shimazaki S,Kurosawa A,Torii Y,Takahashi H,Iwata H,Kuwayama T,Shirasuna K

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Fri Aug 27 00:00:00 EDT 2021

Effect of IL-33 on pyroptosis of macrophages in mice with sepsis via NF-κB/p38 MAPK signaling pathway.

Acta cirurgica brasileira

Ke J,Cai G

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunohistochemistry (PFA fixed)

Fri Jun 18 00:00:00 EDT 2021

Effect of IL-33 on pyroptosis of macrophages in mice with sepsis via NF-κB/p38 MAPK signaling pathway.

Acta cirurgica brasileira

Ke J,Cai G

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunohistochemistry (PFA fixed)

Fri Jun 18 00:00:00 EDT 2021

Blockade of IDO-Kynurenine-AhR Axis Ameliorated Colitis-Associated Colon Cancer via Inhibiting Immune Tolerance.

Cellular and molecular gastroenterology and hepatology

Zhang X,Liu X,Zhou W,Du Q,Yang M,Ding Y,Hu R

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunocytochemistry

Fri Mar 25 00:00:00 EDT 2022

Increased Levels of IL-16 in the Central Nervous System during Neuroinflammation Are Associated with Infiltrating Immune Cells and Resident Glial Cells.

Biology

Hridi SU,Barbour M,Wilson C,Franssen AJ,Harte T,Bushell TJ,Jiang HR

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunohistochemistry (Frozen)

Thu May 27 00:00:00 EDT 2021

Increased Levels of IL-16 in the Central Nervous System during Neuroinflammation Are Associated with Infiltrating Immune Cells and Resident Glial Cells.

Biology

Hridi SU,Barbour M,Wilson C,Franssen AJ,Harte T,Bushell TJ,Jiang HR

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunohistochemistry (Frozen)

Thu May 27 00:00:00 EDT 2021

Dual Activity of Ginsenoside Rb1 in Hypertrophic Cardiomyocytes and Activated Macrophages: Implications for the Therapeutic Intervention of Cardiac Hypertrophy.

Journal of inflammation research

Wang S,Cui Y,Xiong M,Li M,Wang P,Cui J,Du X,Chen Y,Zhang T

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunohistochemistry

Sat Apr 23 00:00:00 EDT 2022

Circular RNA SMEK1 promotes neuropathic pain in rats through targeting microRNA-216a-5p to mediate Thioredoxin Interacting Protein (TXNIP) expression.

Bioengineered

Xin Y,Song X,Ge Q

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Western Blot

Wed Dec 01 00:00:00 EST 2021

Mycobacterium tuberculosis Load in Host Cells and the Antibacterial Activity of Alveolar Macrophages Are Linked and Differentially Regulated in Various Lung Lesions of Patients with Pulmonary Tuberculosis.

International journal of molecular sciences

Ufimtseva EG,Eremeeva NI,Umpeleva TV,Vakhrusheva DV,Skornyakov SN

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunohistochemistry

Fri Mar 26 00:00:00 EDT 2021

Serp-1 Promotes Corneal Wound Healing by Facilitating Re-epithelialization and Inhibiting Fibrosis and Angiogenesis.

Frontiers in cardiovascular medicine

Ju B,Guo O,Benissan-Messan DZ,Shawver MH,Chen P,Geng B,Wei S,Yaron JR,Lucas AR,Zhu H

14-0112-82 was used in Immunohistochemistry to provide preclinical data for topical application of Serp-1 to treat corneal wounds.

Fri May 20 00:00:00 EDT 2022

Serp-1 Promotes Corneal Wound Healing by Facilitating Re-epithelialization and Inhibiting Fibrosis and Angiogenesis.

Frontiers in cardiovascular medicine

Ju B,Guo O,Benissan-Messan DZ,Shawver MH,Chen P,Geng B,Wei S,Yaron JR,Lucas AR,Zhu H

14-0112-82 was used in Immunohistochemistry to provide preclinical data for topical application of Serp-1 to treat corneal wounds.

Fri May 20 00:00:00 EDT 2022

Serp-1 Promotes Corneal Wound Healing by Facilitating Re-epithelialization and Inhibiting Fibrosis and Angiogenesis.

Frontiers in cardiovascular medicine

Ju B,Guo O,Benissan-Messan DZ,Shawver MH,Chen P,Geng B,Wei S,Yaron JR,Lucas AR,Zhu H

14-0112-82 was used in Immunohistochemistry to provide preclinical data for topical application of Serp-1 to treat corneal wounds.

Fri May 20 00:00:00 EDT 2022

Developmental chronodisruption alters placental signaling in mice.

PloS one

Clarkson-Townsend DA,Bales KL,Hermetz KE,Burt AA,Pardue MT,Marsit CJ

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunocytochemistry

Wed Nov 24 00:00:00 EST 2021

Developmental chronodisruption alters placental signaling in mice.

PloS one

Clarkson-Townsend DA,Bales KL,Hermetz KE,Burt AA,Pardue MT,Marsit CJ

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunocytochemistry

Wed Nov 24 00:00:00 EST 2021

Genetic fate-mapping reveals surface accumulation but not deep organ invasion of pleural and peritoneal cavity macrophages following injury.

Nature communications

Jin H,Liu K,Tang J,Huang X,Wang H,Zhang Q,Zhu H,Li Y,Pu W,Zhao H,He L,Li Y,Zhang S,Zhang Z,Zhao Y,Qin Y,Pflanz S,Kasmi KEI,Zhang W,Liu Z,Ginhoux F,Ji Y,He B,Wang L,Zhou B

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Mon May 17 00:00:00 EDT 2021

Genetic fate-mapping reveals surface accumulation but not deep organ invasion of pleural and peritoneal cavity macrophages following injury.

Nature communications

Jin H,Liu K,Tang J,Huang X,Wang H,Zhang Q,Zhu H,Li Y,Pu W,Zhao H,He L,Li Y,Zhang S,Zhang Z,Zhao Y,Qin Y,Pflanz S,Kasmi KEI,Zhang W,Liu Z,Ginhoux F,Ji Y,He B,Wang L,Zhou B

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Mon May 17 00:00:00 EDT 2021

Genetic fate-mapping reveals surface accumulation but not deep organ invasion of pleural and peritoneal cavity macrophages following injury.

Nature communications

Jin H,Liu K,Tang J,Huang X,Wang H,Zhang Q,Zhu H,Li Y,Pu W,Zhao H,He L,Li Y,Zhang S,Zhang Z,Zhao Y,Qin Y,Pflanz S,Kasmi KEI,Zhang W,Liu Z,Ginhoux F,Ji Y,He B,Wang L,Zhou B

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Mon May 17 00:00:00 EDT 2021

Genetic fate-mapping reveals surface accumulation but not deep organ invasion of pleural and peritoneal cavity macrophages following injury.

Nature communications

Jin H,Liu K,Tang J,Huang X,Wang H,Zhang Q,Zhu H,Li Y,Pu W,Zhao H,He L,Li Y,Zhang S,Zhang Z,Zhao Y,Qin Y,Pflanz S,Kasmi KEI,Zhang W,Liu Z,Ginhoux F,Ji Y,He B,Wang L,Zhou B

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Mon May 17 00:00:00 EDT 2021

Brd4 modulates diet-induced obesity via PPARγ-dependent Gdf3 expression in adipose tissue macrophages.

JCI insight

Hu X,Dong X,Li G,Chen Y,Chen J,He X,Sun H,Kim DH,Kemper JK,Chen LF

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu Apr 08 00:00:00 EDT 2021

Polarization of Type 1 Macrophages Is Associated with the Severity of Viral Encephalitis Caused by Japanese Encephalitis Virus and Dengue Virus.

Cells

Jhan MK,Chen CL,Shen TJ,Tseng PC,Wang YT,Satria RD,Yu CY,Lin CF

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Mon Nov 15 00:00:00 EST 2021

Pancreatic Cancer Chemotherapy Is Potentiated by Induction of Tertiary Lymphoid Structures in Mice.

Cellular and molecular gastroenterology and hepatology

Delvecchio FR,Fincham REA,Spear S,Clear A,Roy-Luzarraga M,Balkwill FR,Gribben JG,Bombardieri M,Hodivala-Dilke K,Capasso M,Kocher HM

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Mon Mar 28 00:00:00 EDT 2022

Myeloid DJ-1 deficiency protects acetaminophen-induced acute liver injury through decreasing inflammatory response.

Aging

Wang B,Li J,Jiao J,Xu M,Luo Y,Wang F,Xia Q,Gao Y,Feng Y,Kong X,Sun X

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Wed Jul 21 00:00:00 EDT 2021

Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway.

Nature communications

Fujino T,Goyama S,Sugiura Y,Inoue D,Asada S,Yamasaki S,Matsumoto A,Yamaguchi K,Isobe Y,Tsuchiya A,Shikata S,Sato N,Morinaga H,Fukuyama T,Tanaka Y,Fukushima T,Takeda R,Yamamoto K,Honda H,Nishimura EK,Furukawa Y,Shibata T,Abdel-Wahab O,Suematsu M,Kitamura T

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Mar 23 00:00:00 EDT 2021

M2 macrophage microvesicle-inspired nanovehicles improve accessibility to cancer cells and cancer stem cells in tumors.

Journal of nanobiotechnology

Wang Y,Gong X,Li J,Wang H,Xu X,Wu Y,Wang J,Wang S,Li Y,Zhang Z

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Neutralization

Sat Nov 27 00:00:00 EST 2021

Abraxane-induced bone marrow CD11b⁺ myeloid cell depletion in tumor-bearing mice is visualized by μPET-CT with ⁶⁴Cu-labeled anti-CD11b and prevented by anti-CSF-1.

Theranostics

Cao Q,Huang Q,Wang YA,Li C

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Fri Jul 23 00:00:00 EDT 2021

Abraxane-induced bone marrow CD11b⁺ myeloid cell depletion in tumor-bearing mice is visualized by μPET-CT with ⁶⁴Cu-labeled anti-CD11b and prevented by anti-CSF-1.

Theranostics

Cao Q,Huang Q,Wang YA,Li C

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Fri Jul 23 00:00:00 EDT 2021

In vitro and ex vivo evaluation of tumor-derived exosome-induced dendritic cell dysfunction in mouse.

STAR protocols

Zeng W,Yin X,Jiang Y,Jin L,Liang W

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Fri Mar 19 00:00:00 EDT 2021

Platelet-Like Fusogenic Liposome-Mediated Targeting Delivery of miR-21 Improves Myocardial Remodeling by Reprogramming Macrophages Post Myocardial Ischemia-Reperfusion Injury.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Tan H,Song Y,Chen J,Zhang N,Wang Q,Li Q,Gao J,Yang H,Dong Z,Weng X,Wang Z,Sun D,Yakufu W,Pang Z,Huang Z,Ge J

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Sun Aug 01 00:00:00 EDT 2021

Synergistic immunotherapy of glioblastoma by dual targeting of IL-6 and CD40.

Nature communications

Yang F,He Z,Duan H,Zhang D,Li J,Yang H,Dorsey JF,Zou W,Nabavizadeh SA,Bagley SJ,Abdullah K,Brem S,Zhang L,Xu X,Byrne KT,Vonderheide RH,Gong Y,Fan Y

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Jun 08 00:00:00 EDT 2021

Microglia RAGE exacerbates the progression of neurodegeneration within the SOD1^G93A murine model of amyotrophic lateral sclerosis in a sex-dependent manner.

Journal of neuroinflammation

MacLean M,Juranek J,Cuddapah S,López-Díez R,Ruiz HH,Hu J,Frye L,Li H,Gugger PF,Schmidt AM

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunohistochemistry (PFA fixed)

Tue Jun 15 00:00:00 EDT 2021

Microglia RAGE exacerbates the progression of neurodegeneration within the SOD1^G93A murine model of amyotrophic lateral sclerosis in a sex-dependent manner.

Journal of neuroinflammation

MacLean M,Juranek J,Cuddapah S,López-Díez R,Ruiz HH,Hu J,Frye L,Li H,Gugger PF,Schmidt AM

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunohistochemistry (PFA fixed)

Tue Jun 15 00:00:00 EDT 2021

Mechanical Stress Induce PG-E2 in Murine Synovial Fibroblasts Originating from the Temporomandibular Joint.

Cells

Nazet U,Feulner L,Muschter D,Neubert P,Schatz V,Grässel S,Jantsch J,Proff P,Schröder A,Kirschneck C

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2021

Electronic Cigarette Exposure Enhances Lung Inflammatory and Fibrotic Responses in COPD Mice.

Frontiers in pharmacology

Han H,Peng G,Meister M,Yao H,Yang JJ,Zou MH,Liu ZR,Ji X

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Sat Apr 02 00:00:00 EDT 2022

Small-molecule antagonist of VLA-4 (GW559090) attenuated neuro-inflammation by targeting Th17 cell trafficking across the blood-retinal barrier in experimental autoimmune uveitis.

Journal of neuroinflammation

Chen YH,Eskandarpour M,Zhang X,Galatowicz G,Greenwood J,Lightman S,Calder V

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu Feb 18 00:00:00 EST 2021

STING Activated Tumor-Intrinsic Type I Interferon Signaling Promotes CXCR3 Dependent Antitumor Immunity in Pancreatic Cancer.

Cellular and molecular gastroenterology and hepatology

Vonderhaar EP,Barnekow NS,McAllister D,McOlash L,Eid MA,Riese MJ,Tarakanova VL,Johnson BD,Dwinell MB

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Mon Jan 24 00:00:00 EST 2022

The hepatocyte growth factor/c-met pathway is a key determinant of the fibrotic kidney local microenvironment.

iScience

Fu H,Gui Y,Liu S,Wang Y,Bastacky SI,Qiao Y,Zhang R,Bonin C,Hargis G,Yu Y,Kreutzer DL,Biswas PS,Zhou Y,Wang Y,Tian XJ,Liu Y,Zhou D

14-0112-82 was used in Flow Cytometry to validate that loss of c-met influences epithelial plasticity, myofibroblast activation, and extracellular matrix synthesis/degradation, which ultimately determined the characteristics of the fibrotic KLM.

Fri Oct 22 00:00:00 EDT 2021

Prevention of non-alcoholic steatohepatitis by long-term exercise via the induction of phenotypic changes in Kupffer cells of hyperphagic obese mice.

Physiological reports

Miura I,Komine S,Okada K,Wada S,Warabi E,Uchida F,Oh S,Suzuki H,Mizokami Y,Shoda J

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Sat May 01 00:00:00 EDT 2021

Roles of lung-recruited monocytes and pulmonary Vascular Endothelial Growth Factor (VEGF) in resolving Ventilator-Induced Lung Injury (VILI).

PloS one

Lin CK,Huang TH,Yang CT,Shi CS

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Oct 12 00:00:00 EDT 2021

Desiccation Induced Conjunctival Monocyte Recruitment and Activation - Implications for Keratoconjunctivitis.

Frontiers in immunology

Alam J,de Paiva CS,Pflugfelder SC

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Fri Dec 10 00:00:00 EST 2021

STING activation normalizes the intraperitoneal vascular-immune microenvironment and suppresses peritoneal carcinomatosis of colon cancer.

Journal for immunotherapy of cancer

Lee SJ,Yang H,Kim WR,Lee YS,Lee WS,Kong SJ,Lee HJ,Kim JH,Cheon J,Kang B,Chon HJ,Kim C

14-0112-82 was used in Immunocytochemistry to elucidate the immune-evasion mechanisms during the peritoneal carcinomatosis of colon cancer and developed a novel immunotherapy by activating the stimulator of interferon genes (STING) pathway.

Tue Jun 01 00:00:00 EDT 2021

Macrophages in SHH subgroup medulloblastoma display dynamic heterogeneity that varies with treatment modality.

Cell reports

Dang MT,Gonzalez MV,Gaonkar KS,Rathi KS,Young P,Arif S,Zhai L,Alam Z,Devalaraja S,To TKJ,Folkert IW,Raman P,Rokita JL,Martinez D,Taroni JN,Shapiro JA,Greene CS,Savonen C,Mafra F,Hakonarson H,Curran T,Haldar M

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Mar 30 00:00:00 EDT 2021

Systemic administration of β-glucan induces immune training in microglia.

Journal of neuroinflammation

Heng Y,Zhang X,Borggrewe M,van Weering HRJ,Brummer ML,Nijboer TW,Joosten LAB,Netea MG,Boddeke EWGM,Laman JD,Eggen BJL

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Mon Feb 22 00:00:00 EST 2021

Inflammation-induced alterations in maternal-fetal Heme Oxygenase (HO) are associated with sustained innate immune cell dysregulation in mouse offspring.

PloS one

Ozen M,Zhao H,Kalish F,Yang Y,Jantzie LL,Wong RJ,Stevenson DK

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Wed Nov 17 00:00:00 EST 2021

A Population of M2 Macrophages Associated With Bone Formation.

Frontiers in immunology

Olmsted-Davis E,Mejia J,Salisbury E,Gugala Z,Davis AR

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Mon Dec 13 00:00:00 EST 2021

Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells.

Nature

Zhang B,Ma S,Rachmin I,He M,Baral P,Choi S,Gonçalves WA,Shwartz Y,Fast EM,Su Y,Zon LI,Regev A,Buenrostro JD,Cunha TM,Chiu IM,Fisher DE,Hsu YC

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunohistochemistry

Wed Jan 01 00:00:00 EST 2020

Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells.

Nature

Zhang B,Ma S,Rachmin I,He M,Baral P,Choi S,Gonçalves WA,Shwartz Y,Fast EM,Su Y,Zon LI,Regev A,Buenrostro JD,Cunha TM,Chiu IM,Fisher DE,Hsu YC

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunohistochemistry

Wed Jan 01 00:00:00 EST 2020

Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer.

Cell research

Wang S,Qu Y,Xia P,Chen Y,Zhu X,Zhang J,Wang G,Tian Y,Ying J,Fan Z

14-0112-82 was used in Flow Cytometry to profile tumor infiltrating innate lymphoid cells in colorectal cancer at early and late stages.

Wed Jul 01 00:00:00 EDT 2020

Dual-Wavelength Photosensitive Nano-in-Micro Scaffold Regulates Innate and Adaptive Immune Responses for Osteogenesis.

Nano-micro letters

Zhao Q,Shi M,Yin C,Zhao Z,Zhang J,Wang J,Shen K,Zhang L,Tang H,Xiao Y,Zhang Y

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Sat Nov 21 00:00:00 EST 2020

B cells are sufficient to prime the dominant CD4+ Tfh response to Plasmodium infection.

The Journal of experimental medicine

Arroyo EN,Pepper M

14-0112-82 was used in Flow Cytometry to study antigen-specific CD4+ T follicular helper (Tfh) cells responding to Plasmodium infection in order to understand the generation and maintenance of the Tfh response.

Mon Feb 03 00:00:00 EST 2020

LRRK2 and Rab10 coordinate macropinocytosis to mediate immunological responses in phagocytes.

The EMBO journal

Liu Z,Xu E,Zhao HT,Cole T,West AB

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunocytochemistry

Thu Oct 15 00:00:00 EDT 2020

LRRK2 and Rab10 coordinate macropinocytosis to mediate immunological responses in phagocytes.

The EMBO journal

Liu Z,Xu E,Zhao HT,Cole T,West AB

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunocytochemistry

Thu Oct 15 00:00:00 EDT 2020

Proenkephalin⁺ regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function.

Proceedings of the National Academy of Sciences of the United States of America

Shime H,Odanaka M,Tsuiji M,Matoba T,Imai M,Yasumizu Y,Uraki R,Minohara K,Watanabe M,Bonito AJ,Fukuyama H,Ohkura N,Sakaguchi S,Morita A,Yamazaki S

14-0112-82 was used in Flow Cytometry to report a feature of skin Treg cells expanded by ultraviolet B (UVB) exposure.

Tue Aug 25 00:00:00 EDT 2020

Inflammation shapes pathogenesis of murine arrhythmogenic cardiomyopathy.

Basic research in cardiology

Lubos N,van der Gaag S,Gerçek M,Kant S,Leube RE,Krusche CA

14-0112 was used in Immunohistochemistry to investigate if specific immune cell populations and chemokine expression profiles modulate inflammatory and repair processes throughout arrhythmogenic cardiomyopathy progression.

Fri Jun 12 00:00:00 EDT 2020

Desert Hedgehog-Driven Endothelium Integrity Is Enhanced by Gas1 (Growth Arrest-Specific 1) but Negatively Regulated by Cdon (Cell Adhesion Molecule-Related/Downregulated by Oncogenes).

Arteriosclerosis, thrombosis, and vascular biology

Chapouly C,Hollier PL,Guimbal S,Cornuault L,Gadeau AP,Renault MA

14-0112-86 was used in Immunocytochemistry to investigate whether hedgehog coreceptors Gas1 (growth arrest-specific 1) and Cdon (cell adhesion molecule-related/downregulated by oncogenes) may be used as therapeutic targets to modulate Dhh signaling in ECs.

Tue Dec 01 00:00:00 EST 2020

IgE Contributes to Atherosclerosis and Obesity by Affecting Macrophage Polarization, Macrophage Protein Network, and Foam Cell Formation.

Arteriosclerosis, thrombosis, and vascular biology

Zhang X,Li J,Luo S,Wang M,Huang Q,Deng Z,de Febbo C,Daoui A,Liew PX,Sukhova GK,Metso J,Jauhiainen M,Shi GP,Guo J

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Sun Mar 01 00:00:00 EST 2020

Mincle/Syk Signalling Promotes Intestinal Mucosal Inflammation Through Induction of Macrophage Pyroptosis in Crohn's Disease.

Journal of Crohn's & colitis

Gong W,Zheng T,Guo K,Fang M,Xie H,Li W,Tang Q,Hong Z,Ren H,Gu G,Wang G,Wu X,Zhao Y,Ren J

14-0112 was used in Flow cytometry/Cell sorting to show that Mincle signaling is significantly elevated in active human CD and experimental colitis, and macrophages are the principal leukocyte subset that up-regulate Mincle signaling.

Wed Dec 02 00:00:00 EST 2020

Targeting miR-27a/VE-cadherin interactions rescues cerebral cavernous malformations in mice.

PLoS biology

Li J,Zhao Y,Choi J,Ting KK,Coleman P,Chen J,Cogger VC,Wan L,Shi Z,Moller T,Zheng X,Vadas MA,Gamble JR

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunohistochemistry

Mon Jun 01 00:00:00 EDT 2020

Modulation of the functions of myeloid-derived suppressor cells : a new strategy of hydrogen sulfide anti-cancer effects.

British journal of pharmacology

De Cicco P,Ercolano G,Rubino V,Terrazzano G,Ruggiero G,Cirino G,Ianaro A

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Sat Feb 01 00:00:00 EST 2020

Alpha-hemolysin of uropathogenic Escherichia coli induces GM-CSF-mediated acute kidney injury.

Mucosal immunology

Wang C,Li Q,Lv J,Sun X,Cao Y,Yu K,Miao C,Zhang ZS,Yao Z,Wang Q

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Wed Jan 01 00:00:00 EST 2020

Temporospatial distribution and transcriptional profile of retinal microglia in the oxygen-induced retinopathy mouse model.

Glia

Boeck M,Thien A,Wolf J,Hagemeyer N,Laich Y,Yusuf D,Backofen R,Zhang P,Boneva S,Stahl A,Hilgendorf I,Agostini H,Prinz M,Wieghofer P,Schlunck G,Schlecht A,Lange C

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Sep 01 00:00:00 EDT 2020

Characterization and regulation of osteoclast precursors following chronic Porphyromonas gingivalis infection.

Journal of leukocyte biology

Zhao Y,Li Z,Su L,Ballesteros-Tato A,Katz J,Michalek SM,Feng X,Zhang P

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu Oct 01 00:00:00 EDT 2020

Lymphatic Proliferation Ameliorates Pulmonary Fibrosis after Lung Injury.

The American journal of pathology

Baluk P,Naikawadi RP,Kim S,Rodriguez F,Choi D,Hong YK,Wolters PJ,McDonald DM

14-0112-82 was used in Immunohistochemistry to suggest that lymphatics have an overall protective effect in lung injury and fibrosis and fit with a mechanism whereby lung lymphatic network expansion reduces lymph stasis and increases clearance of fluid and cells, including profibrotic macrophages.

Tue Dec 01 00:00:00 EST 2020

Vitronectin mitigates stroke-increased neurogenesis only in female mice and through FAK-regulated IL-6.

Experimental neurology

Jia C,Keasey MP,Malone HM,Lovins C,Hagg T

14-0112-82 was used in Immunohistochemistry (Frozen) to study the role of vitronectin (VTN) in response to ischaemic stroke in adult mice.

Wed Jan 01 00:00:00 EST 2020

T-B Lymphocyte Interactions Promote Type 1 Diabetes Independently of SLAM-Associated Protein.

Journal of immunology (Baltimore, Md. : 1950)

Bonami RH,Nyhoff LE,McNitt DH,Hulbert C,Felton JL,Kendall PL,Thomas JW

14-0112-82 was used in Flow Cytometry to understand how fully developed T follicular helper cells contribute to different autoimmune processes, investigating the role of signaling lymphocytic activation molecule-associated protein in type 1 diabetes and autoantibody-mediated arthritis.

Tue Dec 15 00:00:00 EST 2020

Secreted Phospholipase A₂ Group X Acts as an Adjuvant for Type 2 Inflammation, Leading to an Allergen-Specific Immune Response in the Lung.

Journal of immunology (Baltimore, Md. : 1950)

Ogden HL,Lai Y,Nolin JD,An D,Frevert CW,Gelb MH,Altemeier WA,Hallstrand TS

14-0112-82 was used in Flow Cytometry to demonstrate that exogenous and endogenous sPLA2s play an important role in peripheral sensitization, resulting in airway responses to inhaled Ags.

Mon Jun 15 00:00:00 EDT 2020

Wounding Induces Facultative Opn5-Dependent Circadian Photoreception in the Murine Cornea.

Investigative ophthalmology & visual science

Díaz NM,Lang RA,Van Gelder RN,Buhr ED

14-0112 was used in Immunohistochemistry to demonstrate that opsin-dependent direct light sensitivity can be facultatively induced in the murine cornea.

Wed Jun 03 00:00:00 EDT 2020

Circulating Neutrophils of Nonalcoholic Steatohepatitis Patients Show an Activated Phenotype and Suppress T Lymphocytes Activity.

Journal of immunology research

Antonucci L,Porcu C,Timperi E,Santini SJ,Iannucci G,Balsano C

14-0112 was used in Flow cytometry/Cell sorting to evaluate the frequency of PolyMorphonuclear Neutrophils in NAFL and NASH patients in order to understand how they modulate the activity of circulating cells.

Fri May 21 00:00:00 EDT 2021

Mouse bone marrow mesenchymal stem cells with distinct p53 statuses display differential characteristics.

Molecular medicine reports

Wang B,Wang L,Mao J,Wen H,Xu L,Ren Y,Du H,Yang H

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Fri May 01 00:00:00 EDT 2020

Senolytic Agent Navitoclax Inhibits Angiotensin II-Induced Heart Failure in Mice.

Journal of cardiovascular pharmacology

Jia K,Dai Y,Liu A,Li X,Wu L,Lu L,Bao Y,Jin Q

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunohistochemistry

Thu Oct 01 00:00:00 EDT 2020

Effects of Hypertonic Saline and Hydroxyethyl Starch on Myeloid-Derived Suppressor Cells in Hemorrhagic Shock Mice under Secondary Bacterial Attack.

BioMed research international

Jiang JK,Hong LJ,Lu YQ

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Wed Dec 16 00:00:00 EST 2020

Exploring the Role of Osteosarcoma-Derived Extracellular Vesicles in Pre-Metastatic Niche Formation and Metastasis in the 143-B Xenograft Mouse Osteosarcoma Model.

Cancers

Mazumdar A,Urdinez J,Boro A,Arlt MJE,Egli FE,Niederöst B,Jaeger PK,Moschini G,Muff R,Fuchs B,Snedeker JG,Gvozdenovic A

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunohistochemistry

Fri Nov 20 00:00:00 EST 2020

Exploring the Role of Osteosarcoma-Derived Extracellular Vesicles in Pre-Metastatic Niche Formation and Metastasis in the 143-B Xenograft Mouse Osteosarcoma Model.

Cancers

Mazumdar A,Urdinez J,Boro A,Arlt MJE,Egli FE,Niederöst B,Jaeger PK,Moschini G,Muff R,Fuchs B,Snedeker JG,Gvozdenovic A

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunohistochemistry

Fri Nov 20 00:00:00 EST 2020

Exploring the Role of Osteosarcoma-Derived Extracellular Vesicles in Pre-Metastatic Niche Formation and Metastasis in the 143-B Xenograft Mouse Osteosarcoma Model.

Cancers

Mazumdar A,Urdinez J,Boro A,Arlt MJE,Egli FE,Niederöst B,Jaeger PK,Moschini G,Muff R,Fuchs B,Snedeker JG,Gvozdenovic A

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunohistochemistry

Fri Nov 20 00:00:00 EST 2020

Electrotransfer of IL-15/IL-15Rα Complex for the Treatment of Established Melanoma.

Cancers

Shirley SA,Lundberg CG,Heller R

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunohistochemistry

Wed Oct 21 00:00:00 EDT 2020

Electrotransfer of IL-15/IL-15Rα Complex for the Treatment of Established Melanoma.

Cancers

Shirley SA,Lundberg CG,Heller R

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunohistochemistry

Wed Oct 21 00:00:00 EDT 2020

Divergent Effects of G2019S and R1441C LRRK2 Mutations on LRRK2 and Rab10 Phosphorylations in Mouse Tissues.

Cells

Iannotta L,Biosa A,Kluss JH,Tombesi G,Kaganovich A,Cogo S,Plotegher N,Civiero L,Lobbestael E,Baekelandt V,Cookson MR,Greggio E

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunohistochemistry (PFA fixed)

Thu Oct 22 00:00:00 EDT 2020

Divergent Effects of G2019S and R1441C LRRK2 Mutations on LRRK2 and Rab10 Phosphorylations in Mouse Tissues.

Cells

Iannotta L,Biosa A,Kluss JH,Tombesi G,Kaganovich A,Cogo S,Plotegher N,Civiero L,Lobbestael E,Baekelandt V,Cookson MR,Greggio E

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunohistochemistry (PFA fixed)

Thu Oct 22 00:00:00 EDT 2020

The armed oncolytic adenovirus ZD55-IL-24 eradicates melanoma by turning the tumor cells from the self-state into the nonself-state besides direct killing.

Cell death & disease

Hu HJ,Liang X,Li HL,Du CM,Hao JL,Wang HY,Gu JF,Ni AM,Sun LY,Xiao J,Hu JQ,Yuan H,Dai YS,Jin XT,Zhang KJ,Liu XY

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Mon Nov 30 00:00:00 EST 2020

The armed oncolytic adenovirus ZD55-IL-24 eradicates melanoma by turning the tumor cells from the self-state into the nonself-state besides direct killing.

Cell death & disease

Hu HJ,Liang X,Li HL,Du CM,Hao JL,Wang HY,Gu JF,Ni AM,Sun LY,Xiao J,Hu JQ,Yuan H,Dai YS,Jin XT,Zhang KJ,Liu XY

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Mon Nov 30 00:00:00 EST 2020

Irradiation induces cancer lung metastasis through activation of the cGAS-STING-CCL5 pathway in mesenchymal stromal cells.

Cell death & disease

Zheng Z,Jia S,Shao C,Shi Y

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu May 07 00:00:00 EDT 2020

Therapeutic Role of Inducible Nitric Oxide Synthase Expressing Myeloid-Derived Suppressor Cells in Acetaminophen-Induced Murine Liver Failure.

Frontiers in immunology

Hsu CY,Lin YC,Chang LY,Huang SK,Huang CH,Yang CK,Huang CT,Lin CY

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Jun 15 00:00:00 EDT 2021

Long Non-Coding RNA Hotairm1 Promotes S100A9 Support of MDSC Expansion during Sepsis.

Journal of clinical & cellular immunology

Alkhateeb T,Bah I,Kumbhare A,Youssef D,Yao ZQ,McCall CE,Gazzar ME

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Sat Aug 13 00:00:00 EDT 2022

GDF3 Protects Mice against Sepsis-Induced Cardiac Dysfunction and Mortality by Suppression of Macrophage Pro-Inflammatory Phenotype.

Cells

Wang L,Li Y,Wang X,Wang P,Essandoh K,Cui S,Huang W,Mu X,Liu Z,Wang Y,Peng T,Fan GC

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Fri Jan 03 00:00:00 EST 2020

Differential Activation of Macrophages Based on Their Environment in Advanced Age.

Chonnam medical journal

Lee DY,Lim JS,Cho KA

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Wed Jan 01 00:00:00 EST 2020

Role of IL-4 in bone marrow driven dysregulated angiogenesis and age-related macular degeneration.

eLife

Baba T,Miyazaki D,Inata K,Uotani R,Miyake H,Sasaki SI,Shimizu Y,Inoue Y,Nakamura K

14-0112 was used in Immunohistochemistry to determine the functional role of IL-4 in CNV formation using murine choroidal neovascularization model.

Tue May 05 00:00:00 EDT 2020

The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells.

Nature communications

Naka K,Ochiai R,Matsubara E,Kondo C,Yang KM,Hoshii T,Araki M,Araki K,Sotomaru Y,Sasaki K,Mitani K,Kim DW,Ooshima A,Kim SJ

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu Sep 17 00:00:00 EDT 2020

CRID3, a blocker of apoptosis associated speck like protein containing a card, ameliorates murine spinal cord injury by improving local immune microenvironment.

Journal of neuroinflammation

Chen YQ,Wang SN,Shi YJ,Chen J,Ding SQ,Tang J,Shen L,Wang R,Ding H,Hu JG,Lü HZ

14-0112-86 was used in Immunohistochemistry (Frozen) to study the effect of CRID3 on the local microenvironment and the possible role in neuroprotection following spinal cord injury.

Sat Aug 29 00:00:00 EDT 2020

Lipin-1 Contributes to IL-4 Mediated Macrophage Polarization.

Frontiers in immunology

Chandran S,Schilke RM,Blackburn CMR,Yurochko A,Mirza R,Scott RS,Finck BN,Woolard MD

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Mon Mar 29 00:00:00 EDT 2021

Ly6c^Lo non-classical monocytes promote resolution of rhesus rotavirus-mediated perinatal hepatic inflammation.

Scientific reports

Alkhani A,Levy CS,Tsui M,Rosenberg KA,Polovina K,Mattis AN,Mack M,Van Dyken S,Wang BM,Maher JJ,Nijagal A

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Apr 28 00:00:00 EDT 2020

Stromal CCL2 Signaling Promotes Mammary Tumor Fibrosis through Recruitment of Myeloid-Lineage Cells.

Cancers

Kuziel G,Thompson V,D'Amato JV,Arendt LM

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Jul 28 00:00:00 EDT 2020

Stromal CCL2 Signaling Promotes Mammary Tumor Fibrosis through Recruitment of Myeloid-Lineage Cells.

Cancers

Kuziel G,Thompson V,D'Amato JV,Arendt LM

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Jul 28 00:00:00 EDT 2020

Antimesothelioma Immunotherapy by CTLA-4 Blockade Depends on Active PD1-Based TWIST1 Vaccination.

Molecular therapy oncolytics

Tan Z,Chiu MS,Yan CW,Wong YC,Huang H,Man K,Chen Z

14-0112-82 was used in Flow Cytometry to demonstrate that TWIST1, the basic helix-loop-helix transcription factor, was associated with human mesothelioma tumorigenesis and is required for the invasion and metastasis of mesothelioma in the immune-competent murine AB1 model.

Fri Mar 27 00:00:00 EDT 2020

The immune response after noise damage in the cochlea is characterized by a heterogeneous mix of adaptive and innate immune cells.

Scientific reports

Rai V,Wood MB,Feng H,Schabla NM,Tu S,Zuo J

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Wed Sep 16 00:00:00 EDT 2020

Macrophage-Associated Lipin-1 Promotes β-Oxidation in Response to Proresolving Stimuli.

ImmunoHorizons

Schilke RM,Blackburn CMR,Rao S,Krzywanski DM,Finck BN,Woolard MD

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Mon Oct 19 00:00:00 EDT 2020

TNFAIP3 Plays a Role in Aging of the Hematopoietic System.

Frontiers in immunology

Smith MA,Culver-Cochran AE,Adelman ER,Rhyasen GW,Ma A,Figueroa ME,Starczynowski DT

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Wed Apr 28 00:00:00 EDT 2021

Novel CD11b⁺Gr-1⁺Sca-1⁺ myeloid cells drive mortality in bacterial infection.

Science advances

Park MY,Kim HS,Lee HY,Zabel BA,Bae YS

14-0112-82 was used in Flow Cytometry to find a previously unidentified pathogenic CD11b+Gr-1+ myeloid cell population that expresses stem cell antigen-1 (Sca-1) induced upon experimental infection with Staphylococcus aureus.

Wed Jan 01 00:00:00 EST 2020

Analysis of the immune response to sciatic nerve injury identifies efferocytosis as a key mechanism of nerve debridement.

eLife

Kalinski AL,Yoon C,Huffman LD,Duncker PC,Kohen R,Passino R,Hafner H,Johnson C,Kawaguchi R,Carbajal KS,Jara JS,Hollis E,Geschwind DH,Segal BM,Giger RJ

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Wed Dec 02 00:00:00 EST 2020

CD103⁺ cDC1 and endogenous CD8⁺ T cells are necessary for improved CD40L-overexpressing CAR T cell antitumor function.

Nature communications

Kuhn NF,Lopez AV,Li X,Cai W,Daniyan AF,Brentjens RJ

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Wed Dec 02 00:00:00 EST 2020

Authentication of Primary Murine Cell Lines by a Microfluidics-Based Lab-On-Chip System.

Biomedicines

Hong Y,Singh N,Bamopoulos S,Gjerga E,Schmalbrock LK,Balabanian K,Schick M,Keller U,Wirth M

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Wed Dec 09 00:00:00 EST 2020

Regorafenib combined with PD1 blockade increases CD8 T-cell infiltration by inducing CXCL10 expression in hepatocellular carcinoma.

Journal for immunotherapy of cancer

Shigeta K,Matsui A,Kikuchi H,Klein S,Mamessier E,Chen IX,Aoki S,Kitahara S,Inoue K,Shigeta A,Hato T,Ramjiawan RR,Staiculescu D,Zopf D,Fiebig L,Hobbs GS,Quaas A,Dima S,Popescu I,Huang P,Munn LL,Cobbold M,Goyal L,Zhu AX,Jain RK,Duda DG

14-0112-82 was used in Flow Cytometry to conclude that judicious regorafenib/anti-PD1 combination therapy can inhibit tumor growth and increase survival by normalizing tumor vasculature and increasing intratumoral CXCR3+CD8 T-cell infiltration through elevated CXCL10 expression in HCC cells.

Sun Nov 01 00:00:00 EDT 2020

Loss of FGFR3 Delays Acute Myeloid Leukemogenesis by Programming Weakly Pathogenic CD117-Positive Leukemia Stem-Like Cells.

Frontiers in pharmacology

Guo C,Ran Q,Sun C,Zhou T,Yang X,Zhang J,Pang S,Xiao Y

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Feb 16 00:00:00 EST 2021

L-Selectin/CD62L is a Key Driver of Non-Alcoholic Steatohepatitis in Mice and Men.

Cells

Drescher HK,Schippers A,Rosenhain S,Gremse F,Bongiovanni L,Bruin A,Eswaran S,Gallage SU,Pfister D,Szydlowska M,Heikenwalder M,Weiskirchen S,Wagner N,Trautwein C,Weiskirchen R,Kroy DC

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Wed Apr 29 00:00:00 EDT 2020

Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target.

JCI insight

Pierini S,Tanyi JL,Simpkins F,George E,Uribe-Herranz M,Drapkin R,Burger R,Morgan MA,Facciabene A

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu Aug 20 00:00:00 EDT 2020

Protein Tyrosine Phosphatase Non-Receptor Type 2 Function in Dendritic Cells Is Crucial to Maintain Tissue Tolerance.

Frontiers in immunology

Hering L,Katkeviciute E,Schwarzfischer M,Busenhart P,Gottier C,Mrdjen D,Komuczki J,Wawrzyniak M,Lang S,Atrott K,Becher B,Rogler G,Scharl M,Spalinger MR

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Mon Apr 12 00:00:00 EDT 2021

Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation.

Nature communications

Iske J,Seyda M,Heinbokel T,Maenosono R,Minami K,Nian Y,Quante M,Falk CS,Azuma H,Martin F,Passos JF,Niemann CU,Tchkonia T,Kirkland JL,Elkhal A,Tullius SG

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu Aug 27 00:00:00 EDT 2020

Androgen Receptor Signaling Positively Regulates Monocytic Development.

Frontiers in immunology

Consiglio CR,Gollnick SO

14-0112 was used in Flow cytometry/Cell sorting to investigate the role of androgen signaling in monocytic differentiation with a genetic mouse model of myeloid androgen receptor (AR) knockout (MARKO) and pharmacological inhibition of AR.

Thu Apr 29 00:00:00 EDT 2021

Hyaluronan control of the primary vascular barrier during early mouse pregnancy is mediated by uterine NK cells.

JCI insight

Hadas R,Gershon E,Cohen A,Atrakchi O,Lazar S,Golani O,Dassa B,Elbaz M,Cohen G,Eilam R,Dekel N,Neeman M

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu Nov 19 00:00:00 EST 2020

Loss of Atg7 causes chaotic nucleosome assembly of mouse bone marrow CD11b⁺Ly6G^- myeloid cells.

Aging

Fang Y,Gu Y,Li L,Zhu L,Qian J,Zhao C,Xu L,Wei W,Du Y,Yuan N,Zhang S,Yuan Y,Xu Y,Jiang C,Wang J

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Nov 24 00:00:00 EST 2020

Bivalent Inhibitor with Selectivity for Trimeric MMP-9 Amplifies Neutrophil Chemotaxis and Enables Functional Studies on MMP-9 Proteoforms.

Cells

Nuti E,Rossello A,Cuffaro D,Camodeca C,Van Bael J,van der Maat D,Martens E,Fiten P,Pereira RVS,Ugarte-Berzal E,Gouwy M,Opdenakker G,Vandooren J

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Jul 07 00:00:00 EDT 2020

Apoptotic bodies derived from mesenchymal stem cells promote cutaneous wound healing via regulating the functions of macrophages.

Stem cell research & therapy

Liu J,Qiu X,Lv Y,Zheng C,Dong Y,Dou G,Zhu B,Liu A,Wang W,Zhou J,Liu S,Liu S,Gao B,Jin Y

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Fri Nov 27 00:00:00 EST 2020

Commensal Microbiota Promote Lung Cancer Development via γδ T Cells.

Cell

Jin C,Lagoudas GK,Zhao C,Bullman S,Bhutkar A,Hu B,Ameh S,Sandel D,Liang XS,Mazzilli S,Whary MT,Meyerson M,Germain R,Blainey PC,Fox JG,Jacks T

14-0112-82 was used in Flow Cytometry to link local microbiota-immune crosstalk to lung tumor development and thereby define key cellular and molecular mediators that may serve as effective targets in lung cancer intervention.

Thu Feb 21 00:00:00 EST 2019

A Subset of Skin Macrophages Contributes to the Surveillance and Regeneration of Local Nerves.

Immunity

Kolter J,Feuerstein R,Zeis P,Hagemeyer N,Paterson N,d'Errico P,Baasch S,Amann L,Masuda T,Lösslein A,Gharun K,Meyer-Luehmann M,Waskow C,Franzke CW,Grün D,Lämmermann T,Prinz M,Henneke P

14-0112 was used in Flow cytometry/Cell sorting to delineate the postnatal development of dermal macrophages and their differentiation into subsets by adapting single-cell transcriptomics, fate mapping, and imaging.

Tue Jun 18 00:00:00 EDT 2019

Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis.

Cell metabolism

Camell CD,Günther P,Lee A,Goldberg EL,Spadaro O,Youm YH,Bartke A,Hubbard GB,Ikeno Y,Ruddle NH,Schultze J,Dixit VD

14-0112 was used in Flow cytometry/Cell sorting to study the role of ageing within alterations of adipose tissue.

Tue Dec 03 00:00:00 EST 2019

Basophil-derived tumor necrosis factor can enhance survival in a sepsis model in mice.

Nature immunology

Piliponsky AM,Shubin NJ,Lahiri AK,Truong P,Clauson M,Niino K,Tsuha AL,Nedospasov SA,Karasuyama H,Reber LL,Tsai M,Mukai K,Galli SJ

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Fri Feb 01 00:00:00 EST 2019

Central nervous system regeneration is driven by microglia necroptosis and repopulation.

Nature neuroscience

Lloyd AF,Davies CL,Holloway RK,Labrak Y,Ireland G,Carradori D,Dillenburg A,Borger E,Soong D,Richardson JC,Kuhlmann T,Williams A,Pollard JW,des Rieux A,Priller J,Miron VE

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Mon Jul 01 00:00:00 EDT 2019

TBKBP1 and TBK1 form a growth factor signalling axis mediating immunosuppression and tumourigenesis.

Nature cell biology

Zhu L,Li Y,Xie X,Zhou X,Gu M,Jie Z,Ko CJ,Gao T,Hernandez BE,Cheng X,Sun SC

14-0112 was used in Flow cytometry/Cell sorting to suggest a PKCθ-TBKBP1-TBK1 growth factor signalling axis that mediates both tumour growth and immunosuppression.

Sun Dec 01 00:00:00 EST 2019

Mechanisms of action of ruxolitinib in murine models of hemophagocytic lymphohistiocytosis.

Blood

Albeituni S,Verbist KC,Tedrick PE,Tillman H,Picarsic J,Bassett R,Nichols KE

14-0112-82 was used in Flow Cytometry to show that ruxolitinib operates through IFN-γ-dependent and -independent mechanisms to dampen HLH by targeting the deleterious effects of T cells and neutrophils, with the latter representing an unappreciated and understudied cell type that contributes to HLH pathogenesis.

Thu Jul 11 00:00:00 EDT 2019

The complex of MCMV proteins and MHC class I evades NK cell control and drives the evolution of virus-specific activating Ly49 receptors.

The Journal of experimental medicine

Železnjak J,Lisnić VJ,Popović B,Lisnić B,Babić M,Halenius A,L'Hernault A,Roviš TL,Hengel H,Erhard F,Redwood AJ,Vidal SM,Dölken L,Krmpotić A,Jonjić S

14-0112 was used in Flow cytometry/Cell sorting to solve a long-standing conundrum of how MCMV avoids recognition by NK cells, unravels a fundamental new viral immune evasion mechanism, and demonstrates how this forced the evolution of virus-specific activating MHC I-restricted Ly49 receptors.

Mon Aug 05 00:00:00 EDT 2019

Antigen-presenting ILC3 regulate T cell-dependent IgA responses to colonic mucosal bacteria.

The Journal of experimental medicine

Melo-Gonzalez F,Kammoun H,Evren E,Dutton EE,Papadopoulou M,Bradford BM,Tanes C,Fardus-Reid F,Swann JR,Bittinger K,Mabbott NA,Vallance BA,Willinger T,Withers DR,Hepworth MR

14-0112-82 was used in Flow Cytometry to study the mechanisms that modulate the magnitude and quality of T cell-dependent IgA responses.

Mon Apr 01 00:00:00 EDT 2019

IL-33 drives influenza-induced asthma exacerbations by halting innate and adaptive antiviral immunity.

The Journal of allergy and clinical immunology

Ravanetti L,Dijkhuis A,Dekker T,Sabogal Pineros YS,Ravi A,Dierdorp BS,Erjefält JS,Mori M,Pavlidis S,Adcock IM,Rao NL,Lutter R

14-0112-82 was used in Flow Cytometry to show that IL-33 drives this increased airway hyperresponsiveness and viral replication and that both lymphoid and myeloid populations infiltrate into the airway lumen and parenchyma, whereas thymic stromal lymphopoietin was redundant in this model.

Mon Apr 01 00:00:00 EDT 2019

TLR1/2 ligand enhances antitumor efficacy of CTLA-4 blockade by increasing intratumoral Treg depletion.

Proceedings of the National Academy of Sciences of the United States of America

Sharma N,Vacher J,Allison JP

14-0112-82 was used in Flow Cytometry to show that this mechanism could be harnessed to modulate the clinical outcome of anti-CTLA-4 antibodies and possibly other antibody-based immunotherapies.

Tue May 21 00:00:00 EDT 2019

Decreased immunoglobulin G in brain regions of elder female APOE4-TR mice accompany with Aβ accumulation.

Immunity & ageing : I & A

Zhang L,Xu J,Gao J,Chen P,Yin M,Zhao W

14-0112-82 was used in Flow Cytometry to determine the alterations of IgG, CD19, and Aβ in various brain regions of uninfected male and female APOE3- and APOE4-TR mice at the age of 3 and 10 months to elucidate impacts of AD risk factors on alterations of brain IgG.

Thu Mar 31 00:00:00 EDT 2022

miR-181a/b-1 controls thymic selection of Treg cells and tunes their suppressive capacity.

PLoS biology

Łyszkiewicz M,Winter SJ,Witzlau K,Föhse L,Brownlie R,Puchałka J,Verheyden NA,Kunze-Schumacher H,Imelmann E,Blume J,Raha S,Sekiya T,Yoshimura A,Frueh JT,Ullrich E,Huehn J,Weiss S,Gutierrez MG,Prinz I,Zamoyska R,Ziętara N,Krueger A

14-0112-82 was used in Flow Cytometry to propose that intrathymic miR-181a/b-1 controls development of Treg cells and imposes a developmental legacy on their peripheral function.

Fri Mar 01 00:00:00 EST 2019

Inhibition of T cell activation and function by the adaptor protein CIN85.

Science signaling

Kong MS,Hashimoto-Tane A,Kawashima Y,Sakuma M,Yokosuka T,Kometani K,Onishi R,Carpino N,Ohara O,Kurosaki T,Phua KK,Saito T

14-0112-82 was used in Flow Cytometry to show that CIN85 (Cbl-interacting protein of 85 kDa) limited T cell responses to T cell receptor stimulation.

Tue Feb 05 00:00:00 EST 2019

Seselin ameliorates inflammation via targeting Jak2 to suppress the proinflammatory phenotype of macrophages.

British journal of pharmacology

Feng L,Sun Y,Song P,Xu L,Wu X,Wu X,Shen Y,Sun Y,Kong L,Wu X,Xu Q

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Jan 01 00:00:00 EST 2019

The P2X7 receptor modulates immune cells infiltration, ectonucleotidases expression and extracellular ATP levels in the tumor microenvironment.

Oncogene

De Marchi E,Orioli E,Pegoraro A,Sangaletti S,Portararo P,Curti A,Colombo MP,Di Virgilio F,Adinolfi E

14-0112-82 was used in Flow Cytometry to explore how ATP's interaction with its receptor P2X7 influences a tumour microenvironment survival mechanisms.

Wed May 01 00:00:00 EDT 2019

Distinct Tie2 tyrosine phosphorylation sites dictate phenotypic switching in endothelial progenitor cells.

Journal of cellular physiology

Siavashi V,Nassiri SM,Rahbarghazi R,Mohseni Z,Sharifi AM

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Wed May 01 00:00:00 EDT 2019

Pericyte transplantation improves skeletal muscle recovery following hindlimb immobilization.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Munroe M,Dvoretskiy S,Lopez A,Leong J,Dyle MC,Kong H,Adams CM,Boppart MD

14-0112-86 was used in Immunohistochemistry (Frozen) to provide the first evidence that pericytes effectively rehabilitate skeletal muscle mass following disuse atrophy.

Sat Jun 01 00:00:00 EDT 2019

Antiallodynic Effects of Cannabinoid Receptor 2 (CB₂R) Agonists on Retrovirus Infection-Induced Neuropathic Pain.

Pain research & management

Sheng WS,Chauhan P,Hu S,Prasad S,Lokensgard JR

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Mon Dec 16 00:00:00 EST 2019

Antitumor and immunomodulatory effects of a novel multitarget inhibitor, CS2164, in mouse hepatocellular carcinoma models.

Anti-cancer drugs

Zhou Y,Fu C,Kong Y,Pan D,Wang Y,Huang S,Li Z,Ning Z,Lu X,Shan S,Xin L

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Oct 01 00:00:00 EDT 2019

TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotection upon Ischemic Stroke in Mice.

Cell reports

Zeng J,Wang Y,Luo Z,Chang LC,Yoo JS,Yan H,Choi Y,Xie X,Deverman BE,Gradinaru V,Gupton SL,Zlokovic BV,Zhao Z,Jung JU

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Apr 09 00:00:00 EDT 2019

Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis.

Nature communications

Zhang X,Zhang H,Xu C,Li X,Li M,Wu X,Pu W,Zhou B,Wang H,Li D,Ding Q,Ying H,Wang H,Zhang H

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Fri Sep 13 00:00:00 EDT 2019

Hemozoin produced by mammals confers heme tolerance.

eLife

Pek RH,Yuan X,Rietzschel N,Zhang J,Jackson L,Nishibori E,Ribeiro A,Simmons W,Jagadeesh J,Sugimoto H,Alam MZ,Garrett L,Haldar M,Ralle M,Phillips JD,Bodine DM,Hamza I

14-0112-82 was used in Flow Cytometry to show that mice deficient for the heme transporter SLC48A1 (also known as HRG1) accumulate over ten-fold excess heme in reticuloendothelial macrophage lysosomes that are 10 to 100 times larger than normal.

Tue Oct 01 00:00:00 EDT 2019

Sequential Sensing by TLR2 and Mincle Directs Immature Myeloid Cells to Protect against Invasive Group A Streptococcal Infection in Mice.

Cell reports

Matsumura T,Ikebe T,Arikawa K,Hosokawa M,Aiko M,Iguchi A,Togashi I,Kai S,Ohara S,Ohara N,Ohnishi M,Watanabe H,Kobayashi K,Takeyama H,Yamasaki S,Takahashi Y,Ato M

14-0112-82 was used in Flow Cytometry to show IFN-γ-producing immature myeloid cells can provide protection to mice in invasive group A Streptococcus infection.

Tue Apr 09 00:00:00 EDT 2019

Discrete viral E2 lysine residues and scavenger receptor MARCO are required for clearance of circulating alphaviruses.

eLife

Carpentier KS,Davenport BJ,Haist KC,McCarthy MK,May NA,Robison A,Ruckert C,Ebel GD,Morrison TE

14-0112-82 was used in Flow Cytometry to reveal a previously unrecognized innate immune pathway that controls alphavirus viremia and dissemination in vertebrate hosts, ultimately influencing disease severity and likely transmission efficiency.

Wed Oct 09 00:00:00 EDT 2019

Neural anti-inflammatory action mediated by two types of acetylcholine receptors in the small intestine.

Scientific reports

Kimura H,Imura YK,Tomiyasu H,Mihara T,Kaji N,Ohno K,Unno T,Tanahashi Y,Jan TR,Tsubone H,Ozaki H,Hori M

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Wed Apr 10 00:00:00 EDT 2019

MDM2 inhibitor APG-115 synergizes with PD-1 blockade through enhancing antitumor immunity in the tumor microenvironment.

Journal for immunotherapy of cancer

Fang DD,Tang Q,Kong Y,Wang Q,Gu J,Fang X,Zou P,Rong T,Wang J,Yang D,Zhai Y

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu Nov 28 00:00:00 EST 2019

Muscularis Propria Macrophages Alter the Proportion of Nitrergic but Not Cholinergic Gastric Myenteric Neurons.

Cellular and molecular gastroenterology and hepatology

Cipriani G,Terhaar ML,Eisenman ST,Ji S,Linden DR,Wright AM,Sha L,Ordog T,Szurszewski JH,Gibbons SJ,Farrugia G

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Jun 04 00:00:00 EDT 2019

Tpl2 Protects Against Fulminant Hepatitis Through Mobilization of Myeloid-Derived Suppressor Cells.

Frontiers in immunology

Xu J,Pei S,Wang Y,Liu J,Qian Y,Huang M,Zhang Y,Xiao Y

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Wed Oct 14 00:00:00 EDT 2020

Exposure to Cigarette Smoke Augments Post-ischemic Brain Injury and Inflammation via Mobilization of Neutrophils and Monocytes.

Frontiers in immunology

Li H,Li X,Gao S,Wang D,Gao X,Li Y,Wang X,Cui Z,Ma H,Liu Q,Li M

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Mon Sep 28 00:00:00 EDT 2020

A Theranostic Cathepsin Activity-Based Probe for Noninvasive Intervention in Cardiovascular Diseases.

Theranostics

Weiss-Sadan T,Ben-Nun Y,Maimoun D,Merquiol E,Abd-Elrahman I,Gotsman I,Blum G

14-0112-82 was used in Immunohistochemistry to demonstrate the potential utility of molecular phototherapy to ameliorate atherosclerosis burden.

Mon Aug 24 00:00:00 EDT 2020

A phospholipase D2 inhibitor, CAY10594, ameliorates acetaminophen-induced acute liver injury by regulating the phosphorylated-GSK-3β/JNK axis.

Scientific reports

Lee SK,Bae GH,Kim YS,Kim HS,Lee M,Ghim J,Zabel BA,Ryu SH,Bae YS

14-0112-82 was used in Flow Cytometry to investigate acetaminophen-induced acute liver injury treatment.

Fri May 10 00:00:00 EDT 2019

Knockdown of Ant2 Reduces Adipocyte Hypoxia And Improves Insulin Resistance in Obesity.

Nature metabolism

Seo JB,Riopel M,Cabrales P,Huh JY,Bandyopadhyay GK,Andreyev AY,Murphy AN,Beeman SC,Smith GI,Klein S,Lee YS,Olefsky JM

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Jan 01 00:00:00 EST 2019

Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses.

Nature communications

Kurelac I,Iommarini L,Vatrinet R,Amato LB,De Luise M,Leone G,Girolimetti G,Umesh Ganesh N,Bridgeman VL,Ombrato L,Columbaro M,Ragazzi M,Gibellini L,Sollazzo M,Feichtinger RG,Vidali S,Baldassarre M,Foriel S,Vidone M,Cossarizza A,Grifoni D,Kofler B,Malanchi I,Porcelli AM,Gasparre G

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Fri Feb 22 00:00:00 EST 2019

Cryoprotectant enables structural control of porous scaffolds for exploration of cellular mechano-responsiveness in 3D.

Nature communications

Jiang S,Lyu C,Zhao P,Li W,Kong W,Huang C,Genin GM,Du Y

14-0112-82 was used in Immunocytochemistry to discover the regulatory effect of cryoprotectants on ice crystal growth and use this property to realise separate control of the scaffold pore size and stiffness.

Fri Aug 02 00:00:00 EDT 2019

Prim-O-glucosylcimifugin enhances the antitumour effect of PD-1 inhibition by targeting myeloid-derived suppressor cells.

Journal for immunotherapy of cancer

Gao W,Zhang X,Yang W,Dou D,Zhang H,Tang Y,Zhong W,Meng J,Bai Y,Liu Y,Yang L,Chen S,Liu H,Yang C,Sun T

14-0112-82 was used in Flow Cytometry to investigate if a potential option for enhancing the efficacy of PD-1 inhibitors in clinical applications exists.

Wed Aug 28 00:00:00 EDT 2019

Small-Animal PET/CT Imaging of Local and Systemic Immune Response Using ⁶⁴Cu-αCD11b.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Cao Q,Huang Q,Mohan C,Li C

14-0112-82 was used in Flow Cytometry to develop the radiotracer 64Cu-labeled anti-CD11b (64Cu-αCD11b) for longitudinal assessment of local and systemic immune response involving mobilization of CD11b+ myeloid cells by small-animal PET/CT.

Sun Sep 01 00:00:00 EDT 2019

Immunostimulatory nanomedicines synergize with checkpoint blockade immunotherapy to eradicate colorectal tumors.

Nature communications

Duan X,Chan C,Han W,Guo N,Weichselbaum RR,Lin W

14-0112 was used in Flow cytometry/Cell sorting to conclude that the intrinsically biodegradable, well tolerated, and systemically available immunostimulatory NCP promises to enter clinical testing as an immunotherapy against colorectal cancer.

Tue Apr 23 00:00:00 EDT 2019

Inducible IL-7 Hyperexpression Influences Lymphocyte Homeostasis and Function and Increases Allograft Rejection.

Frontiers in immunology

Schreiber M,Weigelt M,Karasinsky A,Anastassiadis K,Schallenberg S,Petzold C,Bonifacio E,Kretschmer K,Hommel A

14-0112 was used in Flow cytometry/Cell sorting to show that transient hyperexpression of IL-7 can impair immune regulation, through disturbances in lymphocyte development pathways, and decrease graft survival time, even under immunosuppression.

Mon Sep 14 00:00:00 EDT 2020

Critical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells.

Oncoimmunology

Salerno F,Guislain A,Freen-Van Heeren JJ,Nicolet BP,Young HA,Wolkers MC

14-0112 was used in Flow cytometry/Cell sorting to conclude that post-transcriptional mechanisms could be modulated to potentiate effective T cell therapies in cancer.

Tue Jan 12 00:00:00 EST 2021

Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR.

Nature communications

Zhu H,Bhatt B,Sivaprakasam S,Cai Y,Liu S,Kodeboyina SK,Patel N,Savage NM,Sharma A,Kaufman RJ,Li H,Singh N

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Wed Mar 06 00:00:00 EST 2019

The nuclear variant of bone morphogenetic protein 2 (nBMP2) is expressed in macrophages and alters calcium response.

Scientific reports

Tellez Freitas CM,Burrell HR,Valdoz JC,Hamblin GJ,Raymond CM,Cox TD,Johnson DK,Andersen JL,Weber KS,Bridgewater LC

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Wed Jan 30 00:00:00 EST 2019

Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes.

Nature communications

Galle-Treger L,Sankaranarayanan I,Hurrell BP,Howard E,Lo R,Maazi H,Lewis G,Banie H,Epstein AL,Hu P,Rehan VK,Gilliland FD,Allayee H,Soroosh P,Sharpe AH,Akbari O

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Feb 12 00:00:00 EST 2019

Isolation and Culture of Microglia.

Current protocols in immunology

Bohlen CJ,Bennett FC,Bennett ML

14-0112 was used in Flow cytometry/Cell sorting to describe approaches for purification of microglia by fluorescence-activated cell sorting using microglia-specific surface markers and for enrichment of microglia by magnetic sorting and immunopanning.

Sat Jun 01 00:00:00 EDT 2019

Female and male mouse lung group 2 innate lymphoid cells differ in gene expression profiles and cytokine production.

PloS one

Mathä L,Shim H,Steer CA,Yin YH,Martinez-Gonzalez I,Takei F

14-0112-82 was used in Flow Cytometry to suggest that female ILC2s are more readily activated than male ILC2s due to their gene expression at the naïve state, which is potentially influenced by the lung environment.

Mon Dec 16 00:00:00 EST 2019

Toll-Like Receptor 7 Agonist-Induced Dermatitis Causes Severe Dextran Sulfate Sodium Colitis by Altering the Gut Microbiome and Immune Cells.

Cellular and molecular gastroenterology and hepatology

Kiyohara H,Sujino T,Teratani T,Miyamoto K,Arai MM,Nomura E,Harada Y,Aoki R,Koda Y,Mikami Y,Mizuno S,Naganuma M,Hisamatsu T,Kanai T

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Mon Apr 29 00:00:00 EDT 2019

Molecular Profiling and Functional Analysis of Macrophage-Derived Tumor Extracellular Vesicles.

Cell reports

Cianciaruso C,Beltraminelli T,Duval F,Nassiri S,Hamelin R,Mozes A,Gallart-Ayala H,Ceada Torres G,Torchia B,Ries CH,Ivanisevic J,De Palma M

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunoprecipitation

Tue Jun 04 00:00:00 EDT 2019

Inflammation induced by incomplete radiofrequency ablation accelerates tumor progression and hinders PD-1 immunotherapy.

Nature communications

Shi L,Wang J,Ding N,Zhang Y,Zhu Y,Dong S,Wang X,Peng C,Zhou C,Zhou L,Li X,Shi H,Wu W,Long X,Wu C,Liao W

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu Nov 28 00:00:00 EST 2019

TLR2 Promotes Monocyte/Macrophage Recruitment Into the Liver and Microabscess Formation to Limit the Spread of Listeria Monocytogenes.

Frontiers in immunology

Wang G,Zhao H,Zheng B,Li D,Yuan Y,Han Q,Tian Z,Zhang J

14-0112-82 was used in Flow Cytometry to provide insight into the intrinsic mechanisms of TLR2-induced Mo/MΦ migration and mobility, as well as the interaction between macrophages and hepatocytes in resistance to Lm infection.

Thu Oct 15 00:00:00 EDT 2020

Pluripotency factors functionally premark cell-type-restricted enhancers in ES cells.

Nature

Kim HS,Tan Y,Ma W,Merkurjev D,Destici E,Ma Q,Suter T,Ohgi K,Friedman M,Skowronska-Krawczyk D,Rosenfeld MG

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunofluorescence

Sun Apr 01 00:00:00 EDT 2018

Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release.

Nature

Morioka S,Perry JSA,Raymond MH,Medina CB,Zhu Y,Zhao L,Serbulea V,Onengut-Gumuscu S,Leitinger N,Kucenas S,Rathmell JC,Makowski L,Ravichandran KS

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu Nov 01 00:00:00 EDT 2018

Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host.

Nature

Meisel M,Hinterleitner R,Pacis A,Chen L,Earley ZM,Mayassi T,Pierre JF,Ernest JD,Galipeau HJ,Thuille N,Bouziat R,Buscarlet M,Ringus DL,Wang Y,Li Y,Dinh V,Kim SM,McDonald BD,Zurenski MA,Musch MW,Furtado GC,Lira SA,Baier G,Chang EB,Eren AM,Weber CR,Busque L,Godley LA,Verdú EF,Barreiro LB,Jabri B

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue May 01 00:00:00 EDT 2018

Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells.

Cell

Gaya M,Barral P,Burbage M,Aggarwal S,Montaner B,Warren Navia A,Aid M,Tsui C,Maldonado P,Nair U,Ghneim K,Fallon PG,Sekaly RP,Barouch DH,Shalek AK,Bruckbauer A,Strid J,Batista FD

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu Jan 25 00:00:00 EST 2018

Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.

Cell

Ziegler PK,Bollrath J,Pallangyo CK,Matsutani T,Canli Ö,De Oliveira T,Diamanti MA,Müller N,Gamrekelashvili J,Putoczki T,Horst D,Mankan AK,Öner MG,Müller S,Müller-Höcker J,Kirchner T,Slotta-Huspenina J,Taketo MM,Reinheckel T,Dröse S,Larner AC,Wels WS,Ernst M,Greten TF,Arkan MC,Korn T,Wirth D,Greten FR

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu Jun 28 00:00:00 EDT 2018

A reappraisal of CTLA-4 checkpoint blockade in cancer immunotherapy.

Cell research

Du X,Tang F,Liu M,Su J,Zhang Y,Wu W,Devenport M,Lazarski CA,Zhang P,Wang X,Ye P,Wang C,Hwang E,Zhu T,Xu T,Zheng P,Liu Y

14-0112 was used in in vitro experiments to show that at high concentrations, the anti-CTLA-4 antibody Ipilimumab blocks neither B7 trans-endocytosis by CTLA-4 nor CTLA-4 binding to immobilized or cell-associated B7.

Sun Apr 01 00:00:00 EDT 2018

Chanzyme TRPM7 Mediates the Ca²⁺ Influx Essential for Lipopolysaccharide-Induced Toll-Like Receptor 4 Endocytosis and Macrophage Activation.

Immunity

Schappe MS,Szteyn K,Stremska ME,Mendu SK,Downs TK,Seegren PV,Mahoney MA,Dixit S,Krupa JK,Stipes EJ,Rogers JS,Adamson SE,Leitinger N,Desai BN

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Jan 16 00:00:00 EST 2018

E3 Ligase VHL Promotes Group 2 Innate Lymphoid Cell Maturation and Function via Glycolysis Inhibition and Induction of Interleukin-33 Receptor.

Immunity

Li Q,Li D,Zhang X,Wan Q,Zhang W,Zheng M,Zou L,Elly C,Lee JH,Liu YC

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Feb 20 00:00:00 EST 2018

Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis.

Immunity

Hirota K,Hashimoto M,Ito Y,Matsuura M,Ito H,Tanaka M,Watanabe H,Kondoh G,Tanaka A,Yasuda K,Kopf M,Potocnik AJ,Stockinger B,Sakaguchi N,Sakaguchi S

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Jun 19 00:00:00 EDT 2018

Glucocorticoid receptor promotes the function of myeloid-derived suppressor cells by suppressing HIF1α-dependent glycolysis.

Cellular & molecular immunology

Lu Y,Liu H,Bi Y,Yang H,Li Y,Wang J,Zhang Z,Wang Y,Li C,Jia A,Han L,Hu Y,Zhao Y,Wang R,Liu G

14-0112 was used in Flow cytometry/Cell sorting to reveal the dysregulation of glucocorticoid receptor expression in myeloid-derived suppressor cells during innate immunological hepatic injury and found that GR regulates the function of MDSCs through modulating HIF1α-dependent glycolysis.

Fri Jun 01 00:00:00 EDT 2018

Insulin resistance causes inflammation in adipose tissue.

The Journal of clinical investigation

Shimobayashi M,Albert V,Woelnerhanssen B,Frei IC,Weissenberger D,Meyer-Gerspach AC,Clement N,Moes S,Colombi M,Meier JA,Swierczynska MM,Jenö P,Beglinger C,Peterli R,Hall MN

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Mon Apr 02 00:00:00 EDT 2018

Granulocyte-CSF links destructive inflammation and comorbidities in obstructive lung disease.

The Journal of clinical investigation

Tsantikos E,Lau M,Castelino CM,Maxwell MJ,Passey SL,Hansen MJ,McGregor NE,Sims NA,Steinfort DP,Irving LB,Anderson GP,Hibbs ML

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Fri Jun 01 00:00:00 EDT 2018

TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation.

The Journal of experimental medicine

Malireddi RKS,Gurung P,Mavuluri J,Dasari TK,Klco JM,Chi H,Kanneganti TD

14-0112 was used in Flow cytometry/Cell sorting to identify a critical role for TAK1 in maintaining NLRP3 inflammasome quiescence and preserving cellular homeostasis and survival.

Mon Apr 02 00:00:00 EDT 2018

The E3 ligase VHL controls alveolar macrophage function via metabolic-epigenetic regulation.

The Journal of experimental medicine

Zhang W,Li Q,Li D,Li J,Aki D,Liu YC

14-0112 was used in Flow cytometry/Cell sorting to show VHL regulates alveolar macrophages and acts as a crucial egulatory factor in lung inflammation and fibrosis.

Mon Dec 03 00:00:00 EST 2018

Continuous activity of Foxo1 is required to prevent anergy and maintain the memory state of CD8⁺ T cells.

The Journal of experimental medicine

Delpoux A,Michelini RH,Verma S,Lai CY,Omilusik KD,Utzschneider DT,Redwood AJ,Goldrath AW,Benedict CA,Hedrick SM

14-0112 was used in Flow cytometry/Cell sorting to show that FOXO1 is continuously required for all the phenotypic characteristics of memory-effector T cells.

Mon Feb 05 00:00:00 EST 2018

Tamm-Horsfall Protein Regulates Mononuclear Phagocytes in the Kidney.

Journal of the American Society of Nephrology : JASN

Micanovic R,Khan S,Janosevic D,Lee ME,Hato T,Srour EF,Winfree S,Ghosh J,Tong Y,Rice SE,Dagher PC,Wu XR,El-Achkar TM

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu Mar 01 00:00:00 EST 2018

11 Beta-hydroxysteroid dehydrogenase type 1 regulates synovitis, joint destruction, and systemic bone loss in chronic polyarthritis.

Journal of autoimmunity

Hardy RS,Fenton C,Croft AP,Naylor AJ,Begum R,Desanti G,Buckley CD,Lavery G,Cooper MS,Raza K

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Wed Aug 01 00:00:00 EDT 2018

Seed-induced Aβ deposition is modulated by microglia under environmental enrichment in a mouse model of Alzheimer's disease.

The EMBO journal

Ziegler-Waldkirch S,d'Errico P,Sauer JF,Erny D,Savanthrapadian S,Loreth D,Katzmarski N,Blank T,Bartos M,Prinz M,Meyer-Luehmann M

14-0112 was used in Flow cytometry/Cell sorting to study the impact and functional consequences of induced AB deposits on neurons in Alzheimer's disease.

Wed Jan 17 00:00:00 EST 2018

MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis.

Proceedings of the National Academy of Sciences of the United States of America

Suarez-Lopez L,Sriram G,Kong YW,Morandell S,Merrick KA,Hernandez Y,Haigis KM,Yaffe MB

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunofluorescence

Tue May 01 00:00:00 EDT 2018

MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis.

Proceedings of the National Academy of Sciences of the United States of America

Suarez-Lopez L,Sriram G,Kong YW,Morandell S,Merrick KA,Hernandez Y,Haigis KM,Yaffe MB

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunofluorescence

Tue May 01 00:00:00 EDT 2018

The Synergy of Aging and LPS Exposure in a Mouse Model of Parkinson's Disease.

Aging and disease

Zhao YF,Zhang JF,Lou ZY,Zu HB,Wang ZG,Zeng WC,Xiao BG

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunofluorescence

Mon Oct 01 00:00:00 EDT 2018

Tumor-associated neutrophils suppress pro-tumoral IL-17+ γδ T cells through induction of oxidative stress.

PLoS biology

Mensurado S,Rei M,Lança T,Ioannou M,Gonçalves-Sousa N,Kubo H,Malissen M,Papayannopoulos V,Serre K,Silva-Santos B

14-0112 was used in Flow cytometry/Cell sorting to study the role of tumour-associated neutrophils in the regulation of γδ17 T-cell responses in the tumour microenvironment.

Tue May 01 00:00:00 EDT 2018

Experimental Stroke Differentially Affects Discrete Subpopulations of Splenic Macrophages.

Frontiers in immunology

McCulloch L,Alfieri A,McColl BW

14-0112 was used in Flow cytometry/Cell sorting to study the effects of experimental stroke on discrete splenic macrophage subpopulations.

Tue Jul 30 00:00:00 EDT 2019

VISTA expression by microglia decreases during inflammation and is differentially regulated in CNS diseases.

Glia

Borggrewe M,Grit C,Den Dunnen WFA,Burm SM,Bajramovic JJ,Noelle RJ,Eggen BJL,Laman JD

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Sat Dec 01 00:00:00 EST 2018

Langerin+ DCs regulate innate IL-17 production in the oral mucosa during Candida albicans-mediated infection.

PLoS pathogens

Sparber F,Dolowschiak T,Mertens S,Lauener L,Clausen BE,Joller N,Stoitzner P,Tussiwand R,LeibundGut-Landmann S

14-0112 was used in Flow cytometry/Cell sorting to study innate IL-17 dependent antifungal immunity in the oral mucosa.

Tue May 01 00:00:00 EDT 2018

Bone loss in C57BL/6J-OlaHsd mice, a substrain of C57BL/6J carrying mutated alpha-synuclein and multimerin-1 genes.

Journal of cellular physiology

Liron T,Raphael B,Hiram-Bab S,Bab IA,Gabet Y

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Mon Jan 01 00:00:00 EST 2018

Inactivation of mTORC1 Signaling in Osterix-Expressing Cells Impairs B-cell Differentiation.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Wang Y,Xiao M,Tao C,Chen J,Wang Z,Yang J,Chen Z,Zou Z,Liu A,Cai D,Jiang Y,Ding C,Li M,Bai X

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Sun Apr 01 00:00:00 EDT 2018

Frontline Science: Macrophage-derived exosomes promote neutrophil necroptosis following hemorrhagic shock.

Journal of leukocyte biology

Jiao Y,Li Z,Loughran PA,Fan EK,Scott MJ,Li Y,Billiar TR,Wilson MA,Shi X,Fan J

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu Feb 01 00:00:00 EST 2018

The Outcome of the Cryptococcus neoformans-Macrophage Interaction Depends on Phagolysosomal Membrane Integrity.

Journal of immunology (Baltimore, Md. : 1950)

De Leon-Rodriguez CM,Rossi DCP,Fu MS,Dragotakes Q,Coelho C,Guerrero Ros I,Caballero B,Nolan SJ,Casadevall A

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Sun Jul 15 00:00:00 EDT 2018

Effects of Influenza on Alveolar Macrophage Viability Are Dependent on Mouse Genetic Strain.

Journal of immunology (Baltimore, Md. : 1950)

Califano D,Furuya Y,Metzger DW

14-0112 was used in Flow cytometry/Cell sorting to resolve the apparent inconsistencies in the literature, identify mouse strain-dependent differences in the AM response to influenza infection, and ultimately may facilitate translation of the mouse model to clinical application.

Sun Jul 01 00:00:00 EDT 2018

Multiple Levels of Control Determine How E4bp4/Nfil3 Regulates NK Cell Development.

Journal of immunology (Baltimore, Md. : 1950)

Kostrzewski T,Borg AJ,Meng Y,Filipovic I,Male V,Wack A,DiMaggio PA,Brady HJM

14-0112 was used in Flow cytometry/Cell sorting to reveal mechanisms in NK cell development and that E4bp4 is a central hub to process extrinsic stimuli.

Thu Feb 15 00:00:00 EST 2018

Bruton's Tyrosine Kinase Is Not Essential for B Cell Survival beyond Early Developmental Stages.

Journal of immunology (Baltimore, Md. : 1950)

Nyhoff LE,Clark ES,Barron BL,Bonami RH,Khan WN,Kendall PL

14-0112 was used in Flow cytometry/Cell sorting to raise the possibility that Btk may also be expendable for survival of mature human B cells, therefore requiring prolonged dosing to be effective, and that success of BTK inhibitors may depend in part on off-target effects.

Sun Apr 01 00:00:00 EDT 2018

MicroRNA 33 Regulates the Population of Peripheral Inflammatory Ly6C^high Monocytes through Dual Pathways.

Molecular and cellular biology

Baba O,Horie T,Nakao T,Hakuno D,Nakashima Y,Nishi H,Kuwabara Y,Nishiga M,Nishino T,Ide Y,Nakazeki F,Koyama S,Kimura M,Hanada R,Kawahara M,Kimura T,Ono K

14-0112 was used in Flow cytometry/Cell sorting to indicate that miR-33 deficiency affects distribution of inflammatory monocytes through dual pathways.

Sun Jul 15 00:00:00 EDT 2018

Primary cilia disruption differentially affects the infiltrating and resident macrophage compartment in the liver.

American journal of physiology. Gastrointestinal and liver physiology

Zimmerman KA,Song CJ,Gonzalez-Mize N,Li Z,Yoder BK

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Fri Jun 01 00:00:00 EDT 2018

Anti‑IL‑39 (IL‑23p19/Ebi3) polyclonal antibodies ameliorate autoimmune symptoms in lupus‑like mice.

Molecular medicine reports

Wang X,Zhang Y,Wang Z,Liu X,Zhu G,Han G,Chen G,Hou C,Wang T,Shen B,Li Y,Xiao H,Ma N,Wang R

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Mon Jan 01 00:00:00 EST 2018

A novel method to isolate mesenchymal stem cells from mouse umbilical cord.

Molecular medicine reports

Zhang B,Zhang J,Shi H,Mao F,Wang J,Yan Y,Zhang X,Qian H,Xu W

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Mon Jan 01 00:00:00 EST 2018

Morphine-potentiated cognitive deficits correlate to suppressed hippocampal iNOS RNA expression and an absent type 1 interferon response in LP-BM5 murine AIDS.

Journal of neuroimmunology

McLane VD,Kumar S,Leeming R,Rau S,Willis CL,Cao L

14-0112 was used in Immunohistochemistry to suggest that differentially regulated type 1 IFN responses may contribute to distinct regional outcomes in the hippocampus and striatum in LP-BM5/MAIDS.

Fri Jun 15 00:00:00 EDT 2018

Morphine-potentiated cognitive deficits correlate to suppressed hippocampal iNOS RNA expression and an absent type 1 interferon response in LP-BM5 murine AIDS.

Journal of neuroimmunology

McLane VD,Kumar S,Leeming R,Rau S,Willis CL,Cao L

14-0112 was used in Immunohistochemistry to suggest that differentially regulated type 1 IFN responses may contribute to distinct regional outcomes in the hippocampus and striatum in LP-BM5/MAIDS.

Fri Jun 15 00:00:00 EDT 2018

Simultaneous isolation of mesenchymal stem cells and endothelial progenitor cells derived from murine bone marrow.

Experimental and therapeutic medicine

Wang X,Zhao Z,Zhang H,Hou J,Feng W,Zhang M,Guo J,Xia J,Ge Q,Chen X,Wu X

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Sat Dec 01 00:00:00 EST 2018

Contribution of CD137L to Sensory Hypersensitivity in a Murine Model of Neuropathic Pain.

eNeuro

Wakley AA,Leeming R,Malon J,Arabatzis TJ,Yuen Koh W,Cao L

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunofluorescence

Fri Apr 19 00:00:00 EDT 2019

Analysis of leukocyte transepithelial migration using an in vivo murine colonic loop model.

JCI insight

Flemming S,Luissint AC,Nusrat A,Parkos CA

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunofluorescence

Thu Oct 18 00:00:00 EDT 2018

Macrophage Depletion Protects against Cigarette Smoke-Induced Inflammatory Response in the Mouse Colon and Lung.

Frontiers in physiology

Lim D,Kim W,Lee C,Bae H,Kim J

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunohistochemistry

Wed Sep 30 00:00:00 EDT 2020

Macrophage Depletion Protects against Cigarette Smoke-Induced Inflammatory Response in the Mouse Colon and Lung.

Frontiers in physiology

Lim D,Kim W,Lee C,Bae H,Kim J

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunohistochemistry

Wed Sep 30 00:00:00 EDT 2020

Elimination of intravascular thrombi prevents early mortality and reduces gliosis in hyper-inflammatory experimental cerebral malaria.

Journal of neuroinflammation

Wilson KD,Ochoa LF,Solomon OD,Pal R,Cardona SM,Carpio VH,Keiser PH,Cardona AE,Vargas G,Stephens R

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunofluorescence

Mon Jun 04 00:00:00 EDT 2018

MT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis.

Nature communications

Clemente C,Rius C,Alonso-Herranz L,Martín-Alonso M,Pollán Á,Camafeita E,Martínez F,Mota RA,Núñez V,Rodríguez C,Seiki M,Martínez-González J,Andrés V,Ricote M,Arroyo AG

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Neutralization

Fri Mar 02 00:00:00 EST 2018

iRhom2-mediated proinflammatory signalling regulates heart repair following myocardial infarction.

JCI insight

Barnette DN,Cahill TJ,Gunadasa-Rohling M,Carr CA,Freeman M,Riley PR

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu Feb 08 00:00:00 EST 2018

Establishment of regulatory elements during erythro-megakaryopoiesis identifies hematopoietic lineage-commitment points.

Epigenetics & chromatin

Heuston EF,Keller CA,Lichtenberg J,Giardine B,Anderson SM,Hardison RC,Bodine DM

14-0112 was used in Flow cytometry/Cell sorting to demonstrate that megakaryopoietic profiles are established early in haematopoiesis and are present in the majority of the haematopoietic progenitor population.

Mon May 28 00:00:00 EDT 2018

A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors.

Nature communications

Wang T,Wang D,Yu H,Feng B,Zhou F,Zhang H,Zhou L,Jiao S,Li Y

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Wed Apr 18 00:00:00 EDT 2018

Diet-Induced Obesity Elicits Macrophage Infiltration and Reduction in Spine Density in the Hypothalami of Male but Not Female Mice.

Frontiers in immunology

Lainez NM,Jonak CR,Nair MG,Ethell IM,Wilson EH,Carson MJ,Coss D

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Wed Sep 25 00:00:00 EDT 2019

LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells.

Genome biology

Grigoryan A,Guidi N,Senger K,Liehr T,Soller K,Marka G,Vollmer A,Markaki Y,Leonhardt H,Buske C,Lipka DB,Plass C,Zheng Y,Mulaw MA,Geiger H,Florian MC

14-0112 was used in Flow cytometry/Cell sorting to show that not all histone modifications display a polar localization and that a reduction in H4K16ac amount and loss of epipolarity are specific to aged HSCs.

Wed Nov 07 00:00:00 EST 2018

Microglia prevent peripheral immune cell invasion and promote an anti-inflammatory environment in the brain of APP-PS1 transgenic mice.

Journal of neuroinflammation

Unger MS,Schernthaner P,Marschallinger J,Mrowetz H,Aigner L

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Fri Sep 21 00:00:00 EDT 2018

Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis.

Nature communications

Asada S,Goyama S,Inoue D,Shikata S,Takeda R,Fukushima T,Yonezawa T,Fujino T,Hayashi Y,Kawabata KC,Fukuyama T,Tanaka Y,Yokoyama A,Yamazaki S,Kozuka-Hata H,Oyama M,Kojima S,Kawazu M,Mano H,Kitamura T

14-0112 was used in Flow cytometry/Cell sorting to examine the mechanism by which mutant ASXenopus laevis1 promotes myeloid leukaemogenesis.

Mon Jul 16 00:00:00 EDT 2018

TCRαβ/CD3 disruption enables CD3-specific antileukemic T cell immunotherapy.

JCI insight

Rasaiyaah J,Georgiadis C,Preece R,Mock U,Qasim W

14-0112 was used in Flow cytometry/Cell sorting to demonstrate that 3CAR T cells mediated potent antileukemic effects in a human/murine chimeric model, supporting the application of cellular immunotherapy strategies against T cell malignancies.

Thu Jul 12 00:00:00 EDT 2018

Investigation of tumor-tumor interactions in a double human cervical carcinoma xenograft model in nude mice.

Oncotarget

Mertens B,Cristina de Araujo Nogueira T,Topalis D,Stranska R,Snoeck R,Andrei G

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Apr 24 00:00:00 EDT 2018

BNIP3 modulates the interface between B16-F10 melanoma cells and immune cells.

Oncotarget

Romano E,Rufo N,Korf H,Mathieu C,Garg AD,Agostinis P

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Apr 03 00:00:00 EDT 2018

An immune cell spray (ICS) formulation allows for the delivery of functional monocyte/macrophages.

Scientific reports

Beneke V,Küster F,Neehus AL,Hesse C,Lopez-Rodriguez E,Haake K,Rafiei Hashtchin A,Schott JW,Walter D,Braun A,Wolkers WF,Ackermann M,Lachmann N

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Fri Nov 02 00:00:00 EDT 2018

Early cellular interactions and immune transcriptome profiles in human factor VIII-exposed hemophilia A mice.

Journal of thrombosis and haemostasis : JTH

Lai JD,Cartier D,Hartholt RB,Swystun LL,van Velzen AS,den Haan JMM,Hough C,Voorberg J,Lillicrap D

14-0112 was used in Immunohistochemistry to assess cellular interactions and expression profiles in hemophilia A mice.

Thu Mar 01 00:00:00 EST 2018

Mast Cells Respond to Candida albicans Infections and Modulate Macrophages Phagocytosis of the Fungus.

Frontiers in immunology

De Zuani M,Paolicelli G,Zelante T,Renga G,Romani L,Arzese A,Pucillo CEM,Frossi B

14-0112 was used in Immunocytochemistry-immunoflourescence to unravel the mechanisms of reciprocal influence between mucosal mast cells (MCs) and Candida albicans as commensal/opportunistic pathogen species in humans.

Thu Oct 03 00:00:00 EDT 2019

TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival.

Nature communications

Zhu L,Xie X,Zhang L,Wang H,Jie Z,Zhou X,Shi J,Zhao S,Zhang B,Cheng X,Sun SC

14-0112 was used in Flow cytometry/Cell sorting to study the mechanism of IL-15 function in autophagy and natural killer cell survival.

Wed Jul 18 00:00:00 EDT 2018

Rapid clearance of heavy chain-modified hyaluronan during resolving acute lung injury.

Respiratory research

Ni K,Gill A,Tseng V,Mikosz AM,Koike K,Beatman EL,Xu CY,Cao D,Gally F,Mould KJ,Serban KA,Schweitzer KS,March KL,Janssen WJ,Nozik-Grayck E,Garantziotis S,Petrache I

14-0112 was used in Flow cytometry/Cell sorting to show the covalent HC-HA binding, which is exclusively mediated by tumor necrosis factor α (TNFα)-stimulated-gene-6 (TSG-6), may play an important role in the onset or the resolution of lung inflammation in acute lung injury (ALI) induced by respiratory infection.

Thu May 31 00:00:00 EDT 2018

Calcineurin-mediated IL-2 production by CD11c^highMHCII⁺ myeloid cells is crucial for intestinal immune homeostasis.

Nature communications

Mencarelli A,Khameneh HJ,Fric J,Vacca M,El Daker S,Janela B,Tang JP,Nabti S,Balachander A,Lim TS,Ginhoux F,Ricciardi-Castagnoli P,Mortellaro A

14-0112 was used in Flow cytometry/Cell sorting to show that mice lacking Calcineurin B in CD11chighMHCII+ cells spontaneously develop intestinal inflammation and are susceptible to induced colitis.

Fri Mar 16 00:00:00 EDT 2018

Deep vein thrombosis in mice is regulated by platelet HMGB1 through release of neutrophil-extracellular traps and DNA.

Scientific reports

Dyer MR,Chen Q,Haldeman S,Yazdani H,Hoffman R,Loughran P,Tsung A,Zuckerbraun BS,Simmons RL,Neal MD

14-0112 was used in Flow cytometry/Cell sorting to study the underlying pathophysiology of venous thromboembolic disease.

Thu Feb 01 00:00:00 EST 2018

A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche.

Nature communications

Guarnerio J,Mendez LM,Asada N,Menon AV,Fung J,Berry K,Frenette PS,Ito K,Pandolfi PP

14-0112 was used in Flow cytometry/Cell sorting to show Pml in mesenchymal stem cells regulate pro-inflammatory cytokines which may sustain leukemic cells.

Thu Jan 04 00:00:00 EST 2018

RhoA, Rac1, and Cdc42 differentially regulate αSMA and collagen I expression in mesenchymal stem cells.

The Journal of biological chemistry

Ge J,Burnier L,Adamopoulou M,Kwa MQ,Schaks M,Rottner K,Brakebusch C

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Fri Jun 15 00:00:00 EDT 2018

JNK1 negatively controls antifungal innate immunity by suppressing CD23 expression.

Nature medicine

Zhao X,Guo Y,Jiang C,Chang Q,Zhang S,Luo T,Zhang B,Jia X,Hung MC,Dong C,Lin X

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2017

A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma.

Nature

Tammela T,Sanchez-Rivera FJ,Cetinbas NM,Wu K,Joshi NS,Helenius K,Park Y,Azimi R,Kerper NR,Wesselhoeft RA,Gu X,Schmidt L,Cornwall-Brady M,Yilmaz ÖH,Xue W,Katajisto P,Bhutkar A,Jacks T

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunofluorescence

Thu May 18 00:00:00 EDT 2017

A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma.

Nature

Tammela T,Sanchez-Rivera FJ,Cetinbas NM,Wu K,Joshi NS,Helenius K,Park Y,Azimi R,Kerper NR,Wesselhoeft RA,Gu X,Schmidt L,Cornwall-Brady M,Yilmaz ÖH,Xue W,Katajisto P,Bhutkar A,Jacks T

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunofluorescence

Thu May 18 00:00:00 EDT 2017

Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis.

Nature

Hérault A,Binnewies M,Leong S,Calero-Nieto FJ,Zhang SY,Kang YA,Wang X,Pietras EM,Chu SH,Barry-Holson K,Armstrong S,Göttgens B,Passegué E

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu Apr 06 00:00:00 EDT 2017

Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia.

Nature immunology

Fang J,Bolanos LC,Choi K,Liu X,Christie S,Akunuru S,Kumar R,Wang D,Chen X,Greis KD,Stoilov P,Filippi MD,Maciejewski JP,Garcia-Manero G,Weirauch MT,Salomonis N,Geiger H,Zheng Y,Starczynowski DT

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Wed Feb 01 00:00:00 EST 2017

Hippo signaling interactions with Wnt/β-catenin and Notch signaling repress liver tumorigenesis.

The Journal of clinical investigation

Kim W,Khan SK,Gvozdenovic-Jeremic J,Kim Y,Dahlman J,Kim H,Park O,Ishitani T,Jho EH,Gao B,Yang Y

14011282 was used in flow cytometry to demonstrate that the Hippo, Wnt/beta-catenin, and Notch pathways interact to regulate liver size and inhibit hepatocellular carcinoma

Tue Jan 03 00:00:00 EST 2017

A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer.

The Journal of clinical investigation

Berlato C,Khan MN,Schioppa T,Thompson R,Maniati E,Montfort A,Jangani M,Canosa M,Kulbe H,Hagemann UB,Duncan AR,Fletcher L,Wilkinson RW,Powles T,Quezada SA,Balkwill FR

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2017

TGF-β1 modulates microglial phenotype and promotes recovery after intracerebral hemorrhage.

The Journal of clinical investigation

Taylor RA,Chang CF,Goods BA,Hammond MD,Mac Grory B,Ai Y,Steinschneider AF,Renfroe SC,Askenase MH,McCullough LD,Kasner SE,Mullen MT,Hafler DA,Love JC,Sansing LH

14-0112 was used in Flow cytometry/Cell sorting to investigate the specific responses of microglia following intracerebral haemorrhage with the aim of identifying pathways that may aid in recovery after brain injury.

Tue Jan 03 00:00:00 EST 2017

LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis.

The Journal of experimental medicine

Xu X,Han L,Zhao G,Xue S,Gao Y,Xiao J,Zhang S,Chen P,Wu ZY,Ding J,Hu R,Wei B,Wang H

14-0112 was used in Flow cytometry/Cell sorting to demonstrate LRCH1 as a novel effector to restrain PKCα-DOCK8-Cdc42 module-induced T cell migration and ameliorate EAE.

Sun Jan 01 00:00:00 EST 2017

MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation.

The Journal of experimental medicine

Singh PB,Pua HH,Happ HC,Schneider C,von Moltke J,Locksley RM,Baumjohann D,Ansel KM

14-0112 was used in Flow cytometry/Cell sorting to establish the physiological requirements for miRNAs in ILC2 homeostasis and immune function ans compare the global miRNA repertoire of resting and activated ILC2s and T helper type 2 cells.

Mon Dec 04 00:00:00 EST 2017

Deletion of PIKfyve alters alveolar macrophage populations and exacerbates allergic inflammation in mice.

The EMBO journal

Kawasaki T,Ito K,Miyata H,Akira S,Kawai T

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Wed Jun 14 00:00:00 EDT 2017

Autophagy gene ATG7 regulates ultraviolet radiation-induced inflammation and skin tumorigenesis.

Autophagy

Qiang L,Sample A,Shea CR,Soltani K,Macleod KF,He YY

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunohistochemistry

Fri Jul 05 00:00:00 EDT 2019

Immunosuppressive tumor-infiltrating myeloid cells mediate adaptive immune resistance via a PD-1/PD-L1 mechanism in glioblastoma.

Neuro-oncology

Antonios JP,Soto H,Everson RG,Moughon D,Orpilla JR,Shin NP,Sedighim S,Treger J,Odesa S,Tucker A,Yong WH,Li G,Cloughesy TF,Liau LM,Prins RM

14-0112 was used in Immunohistochemistry to elucidate the role that TIMs play in mediating adaptive immune resistance in the GBM microenvironment and provide evidence that they can be manipulated pharmacologically with agents that are clinically available.

Thu Jun 01 00:00:00 EDT 2017

C-type lectin receptor DCIR modulates immunity to tuberculosis by sustaining type I interferon signaling in dendritic cells.

Proceedings of the National Academy of Sciences of the United States of America

Troegeler A,Mercier I,Cougoule C,Pietretti D,Colom A,Duval C,Vu Manh TP,Capilla F,Poincloux R,Pingris K,Nigou J,Rademann J,Dalod M,Verreck FA,Al Saati T,Lugo-Villarino G,Lepenies B,Hudrisier D,Neyrolles O

14-0112 was used in Flow cytometry/Cell sorting to reveal the modulatory role of the C-type lectin, DCIR, in tuberculosis-associated inflammation.

Tue Jan 24 00:00:00 EST 2017

Deficiency of transcription factor RelB perturbs myeloid and DC development by hematopoietic-extrinsic mechanisms.

Proceedings of the National Academy of Sciences of the United States of America

Briseño CG,Gargaro M,Durai V,Davidson JT,Theisen DJ,Anderson DA,Novack DV,Murphy TL,Murphy KM

14-0112 was used in Flow cytometry/Cell sorting to suggest that there is an unrecognized but critical role for RelB within the nonhematopoietic niche that controls normal myelopoiesis.

Tue Apr 11 00:00:00 EDT 2017

Brd4 modulates the innate immune response through Mnk2-eIF4E pathway-dependent translational control of IκBα.

Proceedings of the National Academy of Sciences of the United States of America

Bao Y,Wu X,Chen J,Hu X,Zeng F,Cheng J,Jin H,Lin X,Chen LF

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue May 16 00:00:00 EDT 2017

Primary Tumors Limit Metastasis Formation through Induction of IL15-Mediated Cross-Talk between Patrolling Monocytes and NK Cells.

Cancer immunology research

Kubo H,Mensurado S,Gonçalves-Sousa N,Serre K,Silva-Santos B

14-0112 was used in Flow cytometry/Cell sorting to identifies an innate cell network and the molecular determinants responsible for metastasis immunosurveillance, providing support for using the key molecular mediator to improve immunotherapeutic outcomes.

Fri Sep 01 00:00:00 EDT 2017

Early Microglia Activation Precedes Photoreceptor Degeneration in a Mouse Model of CNGB1-Linked Retinitis Pigmentosa.

Frontiers in immunology

Blank T,Goldmann T,Koch M,Amann L,Schön C,Bonin M,Pang S,Prinz M,Burnet M,Wagner JE,Biel M,Michalakis S

14-0112 was used in Flow cytometry/Cell sorting to study microglia activation in the development of retinitis pigmentosa.

Wed Nov 20 00:00:00 EST 2019

CCR2^- and CCR2⁺ corneal macrophages exhibit distinct characteristics and balance inflammatory responses after epithelial abrasion.

Mucosal immunology

Liu J,Xue Y,Dong D,Xiao C,Lin C,Wang H,Song F,Fu T,Wang Z,Chen J,Pan H,Li Y,Cai D,Li Z

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Fri Sep 01 00:00:00 EDT 2017

Transcriptional determinants of tolerogenic and immunogenic states during dendritic cell maturation.

The Journal of cell biology

Vander Lugt B,Riddell J,Khan AA,Hackney JA,Lesch J,DeVoss J,Weirauch MT,Singh H,Mellman I

14-0112 was used in Flow cytometry/Cell sorting to study how DCs modulate their ability to prime tolerogenic or immunogenic T cells by expressing a core antigen presentation module that is overlaid by distinctive regulatory modules to promote either tolerance or immunity.

Mon Mar 06 00:00:00 EST 2017

Early IL-6 signalling promotes IL-27 dependent maturation of regulatory T cells in the lungs and resolution of viral immunopathology.

PLoS pathogens

Pyle CJ,Uwadiae FI,Swieboda DP,Harker JA

14-0112-82 was used in Flow Cytometry to show that during respiratory virus infection the prototypic inflammatory cytokine IL-6 is a critical anti-inflammatory regulator of viral induced immunopathology in the respiratory tract through its induction of IL-27.

Fri Sep 01 00:00:00 EDT 2017

Depletion of microglia exacerbates postischemic inflammation and brain injury.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Jin WN,Shi SX,Li Z,Li M,Wood K,Gonzales RJ,Liu Q

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu Jun 01 00:00:00 EDT 2017

NCR1-deficiency diminishes the generation of protective murine cytomegalovirus antibodies by limiting follicular helper T-cell maturation.

European journal of immunology

Miletic A,Lenartic M,Popovic B,Brizic I,Trsan T,Miklic K,Mandelboim O,Krmpotic A,Jonjic S

14-0112 was used in Flow cytometry/Cell sorting to provide evidence for the role of NCR1 in antibody response to mouse cytomegalovirus infection.

Fri Sep 01 00:00:00 EDT 2017

Lymphatic Endothelial Cells Produce M-CSF, Causing Massive Bone Loss in Mice.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Wang W,Wang H,Zhou X,Li X,Sun W,Dellinger M,Boyce BF,Xing L

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Mon May 01 00:00:00 EDT 2017

Lung Epithelial Cell-Derived Microvesicles Regulate Macrophage Migration via MicroRNA-17/221-Induced Integrin β₁ Recycling.

Journal of immunology (Baltimore, Md. : 1950)

Lee H,Zhang D,Wu J,Otterbein LE,Jin Y

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Aug 15 00:00:00 EDT 2017

Silybin attenuates LPS-induced lung injury in mice by inhibiting NF-κB signaling and NLRP3 activation.

International journal of molecular medicine

Zhang B,Wang B,Cao S,Wang Y,Wu D

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Mon May 01 00:00:00 EDT 2017

ADAR1 deletion induces NFκB and interferon signaling dependent liver inflammation and fibrosis.

RNA biology

Ben-Shoshan SO,Kagan P,Sultan M,Barabash Z,Dor C,Jacob-Hirsch J,Harmelin A,Pappo O,Marcu-Malina V,Ben-Ari Z,Amariglio N,Rechavi G,Goldstein I,Safran M

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu May 04 00:00:00 EDT 2017

β3-Adrenergic Regulation of EPC Features Through Manipulation of the Bone Marrow MSC Niche.

Journal of cellular biochemistry

Vafaei R,Nassiri SM,Siavashi V

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Fri Dec 01 00:00:00 EST 2017

Growth inhibition of formed corneal neovascularization following Fosaprepitant treatment.

Acta ophthalmologica

Bignami F,Lorusso A,Rama P,Ferrari G

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Wed Nov 01 00:00:00 EDT 2017

Ethanol, TLR3, and TLR4 Agonists Have Unique Innate Immune Responses in Neuron-Like SH-SY5Y and Microglia-Like BV2.

Alcoholism, clinical and experimental research

Lawrimore CJ,Crews FT

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Mon May 01 00:00:00 EDT 2017

Berberine augments ATP-induced inflammasome activation in macrophages by enhancing AMPK signaling.

Oncotarget

Li CG,Yan L,Jing YY,Xu LH,Liang YD,Wei HX,Hu B,Pan H,Zha QB,Ouyang DY,He XH

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunohistochemistry

Tue Jan 03 00:00:00 EST 2017

HDAC3 inhibition ameliorates spinal cord injury by immunomodulation.

Scientific reports

Kuboyama T,Wahane S,Huang Y,Zhou X,Wong JK,Koemeter-Cox A,Martini M,Friedel RH,Zou H

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunohistochemistry

Thu Aug 17 00:00:00 EDT 2017

Interleukin-1β signaling in fenestrated capillaries is sufficient to trigger sickness responses in mice.

Journal of neuroinflammation

Knoll JG,Krasnow SM,Marks DL

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunofluorescence

Thu Nov 09 00:00:00 EST 2017

Interleukin-1β signaling in fenestrated capillaries is sufficient to trigger sickness responses in mice.

Journal of neuroinflammation

Knoll JG,Krasnow SM,Marks DL

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunofluorescence

Thu Nov 09 00:00:00 EST 2017

Myeloid-specific genetic ablation of ATP-binding cassette transporter ABCA1 is protective against cancer.

Oncotarget

Zamanian-Daryoush M,Lindner DJ,DiDonato JA,Wagner M,Buffa J,Rayman P,Parks JS,Westerterp M,Tall AR,Hazen SL

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Fri Sep 22 00:00:00 EDT 2017

Armored CAR T cells enhance antitumor efficacy and overcome the tumor microenvironment.

Scientific reports

Yeku OO,Purdon TJ,Koneru M,Spriggs D,Brentjens RJ

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Sep 05 00:00:00 EDT 2017

Alternative activation generates IL-10 producing type 2 innate lymphoid cells.

Nature communications

Seehus CR,Kadavallore A,Torre B,Yeckes AR,Wang Y,Tang J,Kaye J

14-0112 was used in Immunocytochemistry to demonstrate the generation of a previously unappreciated IL-10 producing type 2 innate lymphoid cell effector cell population.

Fri Dec 01 00:00:00 EST 2017

Astaxanthin attenuates total body irradiation-induced hematopoietic system injury in mice via inhibition of oxidative stress and apoptosis.

Stem cell research & therapy

Xue XL,Han XD,Li Y,Chu XF,Miao WM,Zhang JL,Fan SJ

14-0112 was used in Flow cytometry/Cell sorting to suggest that ATX could be used as a potent therapeutic agent to protect the hematopoietic system against TBI-induced bone marrow suppression.

Mon Jan 23 00:00:00 EST 2017

MiR-125a Is a critical modulator for neutrophil development.

PLoS genetics

Qin Y,Wu L,Ouyang Y,Zhou P,Zhou H,Wang Y,Ma J,Zhang J,Chen Y,Qian J,Tang Y,Shen N

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Sun Oct 01 00:00:00 EDT 2017

The mTOR signal regulates myeloid-derived suppressor cells differentiation and immunosuppressive function in acute kidney injury.

Cell death & disease

Zhang C,Wang S,Li J,Zhang W,Zheng L,Yang C,Zhu T,Rong R

14-0112 was used in Flow cytometry/Cell sorting to investigate the role of myeloid-derived suppressor cells and mTOR signalling in the protection of acute kidney injury.

Thu Mar 23 00:00:00 EDT 2017

Human amnion cells reverse acute and chronic pulmonary damage in experimental neonatal lung injury.

Stem cell research & therapy

Zhu D,Tan J,Maleken AS,Muljadi R,Chan ST,Lau SN,Elgass K,Leaw B,Mockler J,Chambers D,Leeman KT,Kim CF,Wallace EM,Lim R

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Fri Nov 10 00:00:00 EST 2017

Recipient bone marrow assimilates the myeloid/lymphoid reconstitution of distinct fetal hematopoietic stem cells.

Oncotarget

Guo XL,Chu L,Ke F,Mu LL,Li Z,Cai JJ,Li HF,Hong DL

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Dec 12 00:00:00 EST 2017

The podoplanin-CLEC-2 axis inhibits inflammation in sepsis.

Nature communications

Rayes J,Lax S,Wichaiyo S,Watson SK,Di Y,Lombard S,Grygielska B,Smith SW,Skordilis K,Watson SP

14-0112 was used in Flow cytometry/Cell sorting to demonstrate, through two mouse models of sepsis, the anti-inflammatory role of the podoplanin-CLEC-2 axis.

Thu Dec 21 00:00:00 EST 2017

Loss of epidermal AP1 transcription factor function reduces filaggrin level, alters chemokine expression and produces an ichthyosis-related phenotype.

Cell death & disease

Young CA,Rorke EA,Adhikary G,Xu W,Eckert RL

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu Jun 01 00:00:00 EDT 2017

High fat diet exacerbates murine psoriatic dermatitis by increasing the number of IL-17-producing γδ T cells.

Scientific reports

Nakamizo S,Honda T,Adachi A,Nagatake T,Kunisawa J,Kitoh A,Otsuka A,Dainichi T,Nomura T,Ginhoux F,Ikuta K,Egawa G,Kabashima K

14-0112 was used in Flow cytometry/Cell sorting to indicate that HFD is a key element in exacerbation of IMQ-induced psoriatic dermatitis, and further raise the possibility of HFD as a factor that links obesity and psoriasis.

Thu Oct 26 00:00:00 EDT 2017

Neutrophil swarming and extracellular trap formation play a significant role in Alum adjuvant activity.

NPJ vaccines

Stephen J,Scales HE,Benson RA,Erben D,Garside P,Brewer JM

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Fri Apr 08 00:00:00 EDT 2022

In vivo quantification of quantum dot systemic transport in C57BL/6 hairless mice following skin application post-ultraviolet radiation.

Particle and fibre toxicology

Jatana S,Palmer BC,Phelan SJ,Gelein R,DeLouise LA

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Fri Apr 14 00:00:00 EDT 2017

Experimental lupus is aggravated in mouse strains with impaired induction of neutrophil extracellular traps.

JCI insight

Kienhöfer D,Hahn J,Stoof J,Csepregi JZ,Reinwald C,Urbonaviciute V,Johnsson C,Maueröder C,Podolska MJ,Biermann MH,Leppkes M,Harrer T,Hultqvist M,Olofsson P,Munoz LE,Mocsai A,Herrmann M,Schett G,Holmdahl R,Hoffmann MH

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu May 18 00:00:00 EDT 2017

Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation.

Nature communications

Xu Y,Wang Y,Yan S,Yang Q,Zhou Y,Zeng X,Liu Z,An X,Toque HA,Dong Z,Jiang X,Fulton DJ,Weintraub NL,Li Q,Bagi Z,Hong M,Boison D,Wu C,Huo Y

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Mon Oct 16 00:00:00 EDT 2017

CIITA-driven MHC class II expressing tumor cells can efficiently prime naive CD4⁺ TH cells in vivo and vaccinate the host against parental MHC-II-negative tumor cells.

Oncoimmunology

Bou Nasser Eddine F,Forlani G,Lombardo L,Tedeschi A,Tosi G,Accolla RS

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Jan 12 00:00:00 EST 2021

CD4+ and CD8+ T cells are both needed to induce paraneoplastic neurological disease in a mouse model.

Oncoimmunology

Gebauer C,Pignolet B,Yshii L,Mauré E,Bauer J,Liblau R

14-0112 was used in Flow cytometry/Cell sorting to provide further insight into the cellular mechanisms whereby a potent anti-tumor immunity triggers a cancer-associated autoimmune disease, and may therefore help to develop new therapeutic strategies against PND.

Tue Jan 12 00:00:00 EST 2021

WASH maintains NKp46⁺ ILC3 cells by promoting AHR expression.

Nature communications

Xia P,Liu J,Wang S,Ye B,Du Y,Xiong Z,Han ZG,Tong L,Fan Z

14-0112 was used in Flow cytometry/Cell sorting to study how WASH-mediated AHR expression has a critical function in the maintenance of NKp46(+) ILC3s.

Wed Jun 07 00:00:00 EDT 2017

Autophagy is a signature of a signaling network that maintains hematopoietic stem cells.

PloS one

Nguyen-McCarty M,Klein PS

14-0112 was used in Flow cytometry/Cell sorting to identify the downstream effectors of mTORC1 in hematopoietic stem cells.

Fri Sep 15 00:00:00 EDT 2017

Human and Mouse Hematopoietic Stem Cells Are a Depot for Dormant Mycobacterium tuberculosis.

PloS one

Tornack J,Reece ST,Bauer WM,Vogelzang A,Bandermann S,Zedler U,Stingl G,Kaufmann SH,Melchers F

14-0112-82 was used in Flow Cytometry to conclude that LT-pHSCs, together with MSCs of Mtb-infected humans and mice serve as a hitherto unappreciated quiescent cellular depot for Mtb during latent TB infection.

Tue Sep 05 00:00:00 EDT 2017

Combination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer.

JCI insight

Sato-Kaneko F,Yao S,Ahmadi A,Zhang SS,Hosoya T,Kaneda MM,Varner JA,Pu M,Messer KS,Guiducci C,Coffman RL,Kitaura K,Matsutani T,Suzuki R,Carson DA,Hayashi T,Cohen EE

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu Sep 21 00:00:00 EDT 2017

An asthma-associated IL4R variant exacerbates airway inflammation by promoting conversion of regulatory T cells to TH17-like cells.

Nature medicine

Massoud AH,Charbonnier LM,Lopez D,Pellegrini M,Phipatanakul W,Chatila TA

14-0112 was used in Flow cytometry/Cell sorting to identify a previously unknown mechanism for the development of TH17 cell inflammation in genetically prone individuals.

Thu Sep 01 00:00:00 EDT 2016

Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence.

Nature

Ibiza S,García-Cassani B,Ribeiro H,Carvalho T,Almeida L,Marques R,Misic AM,Bartow-McKenney C,Larson DM,Pavan WJ,Eberl G,Grice EA,Veiga-Fernandes H

14011282 was used in flow cytometry to explain how glial cells impact ILC3-derived IL-22

Thu Jul 21 00:00:00 EDT 2016

Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome.

Cell

Chudnovskiy A,Mortha A,Kana V,Kennard A,Ramirez JD,Rahman A,Remark R,Mogno I,Ng R,Gnjatic S,Amir ED,Solovyov A,Greenbaum B,Clemente J,Faith J,Belkaid Y,Grigg ME,Merad M

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu Oct 06 00:00:00 EDT 2016

The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity.

Cell

Damgaard RB,Walker JA,Marco-Casanova P,Morgan NV,Titheradge HL,Elliott PR,McHale D,Maher ER,McKenzie ANJ,Komander D

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu Aug 25 00:00:00 EDT 2016

Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation.

Nature immunology

Monticelli LA,Buck MD,Flamar AL,Saenz SA,Tait Wojno ED,Yudanin NA,Osborne LC,Hepworth MR,Tran SV,Rodewald HR,Shah H,Cross JR,Diamond JM,Cantu E,Christie JD,Pearce EL,Artis D

14-0112 was used in Flow cytometry/Cell sorting to identify Arg1 as a key regulator of group 2 innate lymphoid cell bioenergetics that control proliferative capacity and pro-inflammatory functions.

Wed Jun 01 00:00:00 EDT 2016

Classical dendritic cells are required for dietary antigen-mediated induction of peripheral T(reg) cells and tolerance.

Nature immunology

Esterházy D,Loschko J,London M,Jove V,Oliveira TY,Mucida D

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Sun May 01 00:00:00 EDT 2016

Oligodendrocyte death results in immune-mediated CNS demyelination.

Nature neuroscience

Traka M,Podojil JR,McCarthy DP,Miller SD,Popko B

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunofluorescence

Fri Jan 01 00:00:00 EST 2016

Oligodendrocyte death results in immune-mediated CNS demyelination.

Nature neuroscience

Traka M,Podojil JR,McCarthy DP,Miller SD,Popko B

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunofluorescence

Fri Jan 01 00:00:00 EST 2016

Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart Failure.

Circulation research

Sager HB,Hulsmans M,Lavine KJ,Moreira MB,Heidt T,Courties G,Sun Y,Iwamoto Y,Tricot B,Khan OF,Dahlman JE,Borodovsky A,Fitzgerald K,Anderson DG,Weissleder R,Libby P,Swirski FK,Nahrendorf M

14-0112 was used in Flow cytometry/Cell sorting to elucidate the origin and roles of macrophages in the post-myocardial infarction remodelling of nonischaemic remote myocardium.

Fri Sep 16 00:00:00 EDT 2016

The breast tumor microenvironment alters the phenotype and function of natural killer cells.

Cellular & molecular immunology

Krneta T,Gillgrass A,Chew M,Ashkar AA

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu Sep 01 00:00:00 EDT 2016

LNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors.

The Journal of clinical investigation

Cheng Y,Chikwava K,Wu C,Zhang H,Bhagat A,Pei D,Choi JK,Tong W

14-0112 was used in Flow cytometry/Cell sorting to investigate how LNK regulates normal B cell development or promotes leukemogenesis.

Fri Apr 01 00:00:00 EDT 2016

Alternatively activated macrophages determine repair of the infarcted adult murine heart.

The Journal of clinical investigation

Shiraishi M,Shintani Y,Shintani Y,Ishida H,Saba R,Yamaguchi A,Adachi H,Yashiro K,Suzuki K

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Wed Jun 01 00:00:00 EDT 2016

Carbonic anhydrase enzymes regulate mast cell-mediated inflammation.

The Journal of experimental medicine

Henry EK,Sy CB,Inclan-Rico JM,Espinosa V,Ghanny SS,Dwyer DF,Soteropoulos P,Rivera A,Siracusa MC

14011282 was used in flow cytometry to find a role for Car enzymes in regulating mast cell lineage commitment

Mon Aug 22 00:00:00 EDT 2016

Successful treatment of murine autoimmune cholangitis by parabiosis: Implications for hematopoietic therapy.

Journal of autoimmunity

Yang JB,Wang YH,Yang W,Lu FT,Ma HD,Zhao ZB,Jia YJ,Tang W,Tsuneyama K,Ridgway WM,Gershwin ME,Lian ZX

14-0112 was used in Magnetic cell separation to investigate the pathways that lead to pathology in a model of primary biliary cirrhosis, showing that CD4(-/-) mice had more severe pathology and parabiosis reduced chalangitis.

Fri Jan 01 00:00:00 EST 2016

The adhesion GPCR BAI1 mediates macrophage ROS production and microbicidal activity against Gram-negative bacteria.

Science signaling

Billings EA,Lee CS,Owen KA,D'Souza RS,Ravichandran KS,Casanova JE

14-0112 was used in Flow cytometry/Cell sorting to demonstrate the role of GPCR BAI1 in the clearance of gram-negative bacteria by stimulation of phagocytosis and initiation of reactive oxygen species production in macrophages.

Tue Feb 02 00:00:00 EST 2016

ATP-Induced Inflammasome Activation and Pyroptosis Is Regulated by AMP-Activated Protein Kinase in Macrophages.

Frontiers in immunology

Zha QB,Wei HX,Li CG,Liang YD,Xu LH,Bai WJ,Pan H,He XH,Ouyang DY

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Wed Nov 20 00:00:00 EST 2019

Loss of Keratin 17 induces tissue-specific cytokine polarization and cellular differentiation in HPV16-driven cervical tumorigenesis in vivo.

Oncogene

Hobbs RP,Batazzi AS,Han MC,Coulombe PA

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunofluorescence

Thu Oct 27 00:00:00 EDT 2016

The B-cell tumor promoter Bcl-3 suppresses inflammation-associated colon tumorigenesis in epithelial cells.

Oncogene

Tang W,Wang H,Ha HL,Tassi I,Bhardwaj R,Claudio E,Siebenlist U

14-0112 was used in Flow cytometry/Cell sorting to study the role of Bcl-3 in AOM/DSS induced colon tumours.

Thu Dec 01 00:00:00 EST 2016

Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis.

Mucosal immunology

Mohapatra A,Van Dyken SJ,Schneider C,Nussbaum JC,Liang HE,Locksley RM

14-0112 was used in Flow cytometry/Cell sorting to study how ILC2s link alveolar function to regulation of airway flow, revealing a key interaction between resident lymphoid and structural cells that might underlie similar organisational hierarchies in other organs.

Fri Jan 01 00:00:00 EST 2016

Opposite Effects of Coinjection and Distant Injection of Mesenchymal Stem Cells on Breast Tumor Cell Growth.

Stem cells translational medicine

Zheng H,Zou W,Shen J,Xu L,Wang S,Fu YX,Fan W

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu Sep 01 00:00:00 EDT 2016

An Epithelial Integrin Regulates the Amplitude of Protective Lung Interferon Responses against Multiple Respiratory Pathogens.

PLoS pathogens

Meliopoulos VA,Van de Velde LA,Van de Velde NC,Karlsson EA,Neale G,Vogel P,Guy C,Sharma S,Duan S,Surman SL,Jones BG,Johnson MD,Bosio C,Jolly L,Jenkins RG,Hurwitz JL,Rosch JW,Sheppard D,Thomas PG,Murray PJ,Schultz-Cherry S

14-0112 was used in Flow cytometry/Cell sorting to show that upregulation of the epithelial integrin αVβ6 during influenza infection is involved in disease pathogenesis.

Mon Aug 01 00:00:00 EDT 2016

Macrophages transfer antigens to dendritic cells by releasing exosomes containing dead-cell-associated antigens partially through a ceramide-dependent pathway to enhance CD4(+) T-cell responses.

Immunology

Xu Y,Liu Y,Yang C,Kang L,Wang M,Hu J,He H,Song W,Tang H

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Sat Oct 01 00:00:00 EDT 2016

Activation of RNase L by Murine Coronavirus in Myeloid Cells Is Dependent on Basal Oas Gene Expression and Independent of Virus-Induced Interferon.

Journal of virology

Birdwell LD,Zalinger ZB,Li Y,Wright PW,Elliott R,Rose KM,Silverman RH,Weiss SR

14-0112 was used in Flow cytometry/Cell sorting to investigate the contributions of Oas gene expression, basal IFN signalling, and virus-induced IFN to RNase L activation.

Wed Jan 06 00:00:00 EST 2016

Identification of a Hematopoietic Cell Dedifferentiation-Inducing Factor.

Journal of cellular physiology

Li Y,Adomat H,Guns ET,Hojabrpour P,Duronio V,Curran TA,Jalili RB,Jia W,Delwar Z,Zhang Y,Elizei SS,Ghahary A

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunocytochemistry

Wed Jun 01 00:00:00 EDT 2016

Dual-therapy with αvβ3-targeted Sn2 lipase-labile fumagillin-prodrug nanoparticles and zoledronic acid in the Vx2 rabbit tumor model.

Nanomedicine : nanotechnology, biology, and medicine

Esser AK,Schmieder AH,Ross MH,Xiang J,Su X,Cui G,Zhang H,Yang X,Allen JS,Williams T,Wickline SA,Pan D,Lanza GM,Weilbaecher KN

14-0112-82 was used in Immunohistochemistry to provide an insight to the design of future drugs against cancers.

Fri Jan 01 00:00:00 EST 2016

Ginsenoside Rd alleviates mouse acute renal ischemia/reperfusion injury by modulating macrophage phenotype.

Journal of ginseng research

Ren K,Jin C,Ma P,Ren Q,Jia Z,Zhu D

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunofluorescence

Fri Apr 01 00:00:00 EDT 2016

Ginsenoside Rd alleviates mouse acute renal ischemia/reperfusion injury by modulating macrophage phenotype.

Journal of ginseng research

Ren K,Jin C,Ma P,Ren Q,Jia Z,Zhu D

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunofluorescence

Fri Apr 01 00:00:00 EDT 2016

Multimodal analysis of ocular inflammation using the endotoxin-induced uveitis mouse model.

Disease models & mechanisms

Chu CJ,Gardner PJ,Copland DA,Liyanage SE,Gonzalez-Cordero A,Kleine Holthaus SM,Luhmann UF,Smith AJ,Ali RR,Dick AD

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Fri Apr 01 00:00:00 EDT 2016

Multimodal analysis of ocular inflammation using the endotoxin-induced uveitis mouse model.

Disease models & mechanisms

Chu CJ,Gardner PJ,Copland DA,Liyanage SE,Gonzalez-Cordero A,Kleine Holthaus SM,Luhmann UF,Smith AJ,Ali RR,Dick AD

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Fri Apr 01 00:00:00 EDT 2016

Lymphatic endothelial lineage assemblage during corneal lymphangiogenesis.

Laboratory investigation; a journal of technical methods and pathology

Connor AL,Kelley PM,Tempero RM

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunofluorescence

Tue Mar 01 00:00:00 EST 2016

T Cell Priming by Activated Nlrc5-Deficient Dendritic Cells Is Unaffected despite Partially Reduced MHC Class I Levels.

Journal of immunology (Baltimore, Md. : 1950)

Rota G,Ludigs K,Siegert S,Tardivel A,Morgado L,Reith W,De Gassart A,Guarda G

14-0112 was used in Flow cytometry/Cell sorting to show that Nlrc5 deficiency is not sufficient to hinder T cell activation, highlighting the robustness of the T cell priming process by activated dendritic cells.

Fri Apr 01 00:00:00 EDT 2016

Type I IFN Does Not Promote Susceptibility to Foodborne Listeria monocytogenes.

Journal of immunology (Baltimore, Md. : 1950)

Pitts MG,Myers-Morales T,D'Orazio SE

14-0112 was used in Flow cytometry/Cell sorting to investigate whether type I IFN promotes susceptibility to foodborne Listeria monocytogenes.

Fri Apr 01 00:00:00 EDT 2016

Regulatory T Cells Control Th2-Dominant Murine Autoimmune Gastritis.

Journal of immunology (Baltimore, Md. : 1950)

Harakal J,Rival C,Qiao H,Tung KS

14-0112-82 was used in Flow Cytometry to suggest that Tregs maintain physiological tolerance to clinically relevant gastric autoantigens, and Th2 responses can be a pathogenic mechanism in AIG.

Fri Jul 01 00:00:00 EDT 2016

Blood Stem Cell Activity Is Arrested by Th1-Mediated Injury Preventing Engraftment following Nonmyeloablative Conditioning.

Journal of immunology (Baltimore, Md. : 1950)

Müller AM,Florek M,Kohrt HE,Küpper NJ,Filatenkov A,Linderman JA,Hadeiba H,Negrin RS,Shizuru JA

14-0112 was used in Flow cytometry/Cell sorting to shed new light on the effects of CD4+ T cells on HSC biology.

Tue Nov 15 00:00:00 EST 2016

Differences between Mycobacterium-Host Cell Relationships in Latent Tuberculous Infection of Mice Ex Vivo and Mycobacterial Infection of Mouse Cells In Vitro.

Journal of immunology research

Ufimtseva E

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunofluorescence

Tue Nov 08 00:00:00 EST 2016

ECM-Dependence of Endothelial Progenitor Cell Features.

Journal of cellular biochemistry

Siavashi V,Nassiri SM,Rahbarghazi R,Vafaei R,Sariri R

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Mon Aug 01 00:00:00 EDT 2016

Dynamics of the spleen and its significance in a murine H22 orthotopic hepatoma model.

Experimental biology and medicine (Maywood, N.J.)

Li B,Zhang S,Huang N,Chen H,Wang P,Li J,Pu Y,Yang J,Li Z

14-0112-82 was used in Flow Cytometry to study the dynamics of the spleen and its significance in a murine H22 orthotopic hepatoma model.

Fri Apr 01 00:00:00 EDT 2016

Comparison of RELMα and RELMβ Single- and Double-Gene-Deficient Mice Reveals that RELMα Expression Dictates Inflammation and Worm Expulsion in Hookworm Infection.

Infection and immunity

Chen G,Wang SH,Jang JC,Odegaard JI,Nair MG

14-0112 was used in Flow cytometry/Cell sorting to delineate the function of two resistin-like molecules, RELMα and RELMβ, following infection with hookworm.

Fri Apr 01 00:00:00 EDT 2016

Rho kinase II interference by small hairpin RNA ameliorates 1‑methyl‑4‑phenyl‑1,2,3,6‑tetrahydropyridine‑induced parkinsonism in mice.

Molecular medicine reports

Zhang Q,Zhao YF,Xi JY,Yu WB,Xiao BG

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunofluorescence

Thu Dec 01 00:00:00 EST 2016

Sertoli cell condition medium can induce germ like cells from bone marrow derived mesenchymal stem cells.

Iranian journal of basic medical sciences

Monfared MH,Minaee B,Rastegar T,Khrazinejad E,Barbarestani M

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Nov 01 00:00:00 EDT 2016

Macrophages form functional vascular mimicry channels in vivo.

Scientific reports

Barnett FH,Rosenfeld M,Wood M,Kiosses WB,Usui Y,Marchetti V,Aguilar E,Friedlander M

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunofluorescence

Fri Nov 11 00:00:00 EST 2016

Macrophages form functional vascular mimicry channels in vivo.

Scientific reports

Barnett FH,Rosenfeld M,Wood M,Kiosses WB,Usui Y,Marchetti V,Aguilar E,Friedlander M

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunofluorescence

Fri Nov 11 00:00:00 EST 2016

Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency.

Stem cell reports

Mucci A,Kunkiel J,Suzuki T,Brennig S,Glage S,Kühnel MP,Ackermann M,Happle C,Kuhn A,Schambach A,Trapnell BC,Hansen G,Moritz T,Lachmann N

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Aug 09 00:00:00 EDT 2016

Endothelial cell-derived CD95 ligand serves as a chemokine in induction of neutrophil slow rolling and adhesion.

eLife

Gao L,Gülcüler GS,Golbach L,Block H,Zarbock A,Martin-Villalba A

14-0112 was used in Flow cytometry/Cell sorting to identify the mechanisms underlying the chemoattractant effect of endothelial cell-derived CD95L in induction of neutrophil recruitment.

Thu Oct 20 00:00:00 EDT 2016

Endothelial cell-derived CD95 ligand serves as a chemokine in induction of neutrophil slow rolling and adhesion.

eLife

Gao L,Gülcüler GS,Golbach L,Block H,Zarbock A,Martin-Villalba A

14-0112 was used in Flow cytometry/Cell sorting to identify the mechanisms underlying the chemoattractant effect of endothelial cell-derived CD95L in induction of neutrophil recruitment.

Thu Oct 20 00:00:00 EDT 2016

Activated c-Kit receptor in the heart promotes cardiac repair and regeneration after injury.

Cell death & disease

Di Siena S,Gimmelli R,Nori SL,Barbagallo F,Campolo F,Dolci S,Rossi P,Venneri MA,Giannetta E,Gianfrilli D,Feigenbaum L,Lenzi A,Naro F,Cianflone E,Mancuso T,Torella D,Isidori AM,Pellegrini M

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu Jul 28 00:00:00 EDT 2016

A New Mouse Model That Spontaneously Develops Chronic Liver Inflammation and Fibrosis.

PloS one

Fransén-Pettersson N,Duarte N,Nilsson J,Lundholm M,Mayans S,Larefalk Å,Hannibal TD,Hansen L,Schmidt-Christensen A,Ivars F,Cardell S,Palmqvist R,Rozell B,Holmberg D

14-0112 was used in Flow cytometry/Cell sorting to establish a new mouse model which spontaneously develops progressive inflammation and fibrosis in multiple organs.

Mon Jul 24 00:00:00 EDT 2017

Endothelial Cell-Selective Adhesion Molecule Expression in Hematopoietic Stem/Progenitor Cells Is Essential for Erythropoiesis Recovery after Bone Marrow Injury.

PloS one

Sudo T,Yokota T,Okuzaki D,Ueda T,Ichii M,Ishibashi T,Isono T,Habuchi Y,Oritani K,Kanakura Y

14-0112 was used in Flow cytometry/Cell sorting to determine the physiological importance of Endothelial Cell-Selective Adhesion Molecule (ESAM) in erythroid recovery, showing that ESAM is essential for erthryopoiesis recovery following bone marrow injury.

Tue Mar 14 00:00:00 EDT 2017

Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells.

Nature communications

Göbel K,Pankratz S,Asaridou CM,Herrmann AM,Bittner S,Merker M,Ruck T,Glumm S,Langhauser F,Kraft P,Krug TF,Breuer J,Herold M,Gross CC,Beckmann D,Korb-Pap A,Schuhmann MK,Kuerten S,Mitroulis I,Ruppert C,Nolte MW,Panousis C,Klotz L,Kehrel B,Korn T,Langer HF,Pap T,Nieswandt B,Wiendl H,Chavakis T,Kleinschnitz C,Meuth SG

14-0112 was used in Flow cytometry/Cell sorting to study how immune activation by FXII is mediated by dendritic cells in a CD87-dependent manner, and involves alterations in intracellular cyclic AMP formation.

Wed May 18 00:00:00 EDT 2016

Brain trauma elicits non-canonical macrophage activation states.

Journal of neuroinflammation

Kim CC,Nakamura MC,Hsieh CL

14-0112 was used in Flow cytometry/Cell sorting to investigate the novel activation states involved in the early macrophage response to traumatic brain injury.

Tue May 24 00:00:00 EDT 2016

Ranitidine modifies myeloid cell populations and inhibits breast tumor development and spread in mice.

Oncoimmunology

Vila-Leahey A,Oldford SA,Marignani PA,Wang J,Haidl ID,Marshall JS

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Fri Jul 01 00:00:00 EDT 2016

Balancing intestinal and systemic inflammation through cell type-specific expression of the aryl hydrocarbon receptor repressor.

Scientific reports

Brandstätter O,Schanz O,Vorac J,König J,Mori T,Maruyama T,Korkowski M,Haarmann-Stemmann T,von Smolinski D,Schultze JL,Abel J,Esser C,Takeyama H,Weighardt H,Förster I

14-0112 was used in Flow cytometry/Cell sorting to highlight the physiologic importance of cell-type specific balancing of AhR/AhRR expression in response to microbial, nutritional and other environmental stimuli.

Tue May 17 00:00:00 EDT 2016

Interleukin 6 regulates psoriasiform inflammation-associated thrombosis.

JCI insight

Wang Y,Golden JB,Fritz Y,Zhang X,Diaconu D,Camhi MI,Gao H,Dawes SM,Xing X,Ganesh SK,Gudjonsson JE,Simon DI,McCormick TS,Ward NL

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu Dec 08 00:00:00 EST 2016

Differential Type I Interferon Signaling Is a Master Regulator of Susceptibility to Postinfluenza Bacterial Superinfection.

mBio

Shepardson KM,Larson K,Morton RV,Prigge JR,Schmidt EE,Huber VC,Rynda-Apple A

14-0112 was used in Flow cytometry/Cell sorting to investigate the response to methicillin-resistant Staphylococcus aureus following infection with influenza A virus.

Tue May 03 00:00:00 EDT 2016

Coagulation induced by C3aR-dependent NETosis drives protumorigenic neutrophils during small intestinal tumorigenesis.

Nature communications

Guglietta S,Chiavelli A,Zagato E,Krieg C,Gandini S,Ravenda PS,Bazolli B,Lu B,Penna G,Rescigno M

14-0112 was used in Flow cytometry/Cell sorting to provide a mechanistic explanation for the tumour-promoting effects of hypercoagulation.

Mon Mar 21 00:00:00 EDT 2016

Immune signatures of protective spleen memory CD8 T cells.

Scientific reports

Brinza L,Djebali S,Tomkowiak M,Mafille J,Loiseau C,Jouve PE,de Bernard S,Buffat L,Lina B,Ottmann M,Rosa-Calatrava M,Schicklin S,Bonnefoy N,Lauvau G,Grau M,Wencker M,Arpin C,Walzer T,Leverrier Y,Marvel J

14-0112 was used in Flow cytometry/Cell sorting to identify a range of qualities uniquely associated with protective memory cells.

Thu Nov 24 00:00:00 EST 2016

Stroke sensitivity in the aged: sex chromosome complement vs. gonadal hormones.

Aging

McCullough LD,Mirza MA,Xu Y,Bentivegna K,Steffens EB,Ritzel R,Liu F

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Fri Jul 01 00:00:00 EDT 2016

NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation.

Nature communications

Yang M,Chen S,Du J,He J,Wang Y,Li Z,Liu G,Peng W,Zeng X,Li D,Xu P,Guo W,Chang Z,Wang S,Tian Z,Dong Z

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Wed Sep 07 00:00:00 EDT 2016

The impact of ranitidine on monocyte responses in the context of solid tumors.

Oncotarget

Vila-Leahey A,Rogers D,Marshall JS

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Mar 08 00:00:00 EST 2016

CXXC finger protein 1 is critical for T-cell intrathymic development through regulating H3K4 trimethylation.

Nature communications

Cao W,Guo J,Wen X,Miao L,Lin F,Xu G,Ma R,Yin S,Hui Z,Chen T,Guo S,Chen W,Huang Y,Liu Y,Wang J,Wei L,Wang L

14-0112 was used in Flow cytometry/Cell sorting to investigate whether the CpG-binding protein Cxxc1 plays a role in thymocyte development.

Mon May 23 00:00:00 EDT 2016

Phenotypic and functional characterization of the major lymphocyte populations in the fruit-eating bat Pteropus alecto.

Scientific reports

Martínez Gómez JM,Periasamy P,Dutertre CA,Irving AT,Ng JH,Crameri G,Baker ML,Ginhoux F,Wang LF,Alonso S

14-0112 was used in Flow cytometry/Cell sorting to identify the unique properties of the bat immune system that enable them to act as a reservoir for viruses that are highly pathogenic to humans.

Thu Nov 24 00:00:00 EST 2016

Loss of the Ubiquitin-conjugating Enzyme UBE2W Results in Susceptibility to Early Postnatal Lethality and Defects in Skin, Immune, and Male Reproductive Systems.

The Journal of biological chemistry

Wang B,Merillat SA,Vincent M,Huber AK,Basrur V,Mangelberger D,Zeng L,Elenitoba-Johnson K,Miller RA,Irani DN,Dlugosz AA,Schnell S,Scaglione KM,Paulson HL

14-0112 was used in Flow cytometry/Cell sorting to establish that UBE2W is an important protein for early postnatal survival and the normal functioning of multiple organ systems.

Fri Feb 05 00:00:00 EST 2016

Stat3 Signaling Promotes Survival And Maintenance Of Medullary Thymic Epithelial Cells.

PLoS genetics

Lomada D,Jain M,Bolner M,Reeh KA,Kang R,Reddy MC,DiGiovanni J,Richie ER

14-0112 was used in Flow cytometry/Cell sorting to demonstrate that in addition to the NFkB pathway, Stat3-mediated signals play an essential role in regulating mTEC cellularity and medullary region homeostasis.

Fri Jan 01 00:00:00 EST 2016

Impaired differentiation of macrophage lineage cells attenuates bone remodeling and inflammatory angiogenesis in Ndrg1 deficient mice.

Scientific reports

Watari K,Shibata T,Nabeshima H,Shinoda A,Fukunaga Y,Kawahara A,Karasuyama K,Fukushi J,Iwamoto Y,Kuwano M,Ono M

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Mon Jan 18 00:00:00 EST 2016

CXCR3 signaling in glial cells ameliorates experimental autoimmune encephalomyelitis by restraining the generation of a pro-Th17 cytokine milieu and reducing CNS-infiltrating Th17 cells.

Journal of neuroinflammation

Chung CY,Liao F

14-0112 was used in Flow cytometry/Cell sorting to demonstrate that CXCR3 in glial cells is critical in restraining the pro-Th17 cytokine/chemokine milieu during experimental autoimmune encephalomyelitis.

Mon Apr 11 00:00:00 EDT 2016

Irradiation of necrotic cancer cells, employed for pulsing dendritic cells (DCs), potentiates DC vaccine-induced antitumor immunity against high-grade glioma.

Oncoimmunology

Vandenberk L,Garg AD,Verschuere T,Koks C,Belmans J,Beullens M,Agostinis P,De Vleeschouwer S,Van Gool SW

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2016

IL-6 Signaling in Myelomonocytic Cells Is Not Crucial for the Development of IMQ-Induced Psoriasis.

PloS one

Klebow S,Hahn M,Nikoalev A,Wunderlich FT,Hövelmeyer N,Karbach SH,Waisman A

14-0112 was used in Flow cytometry/Cell sorting to investigate the role of IL-6 signalling in myelomonocytic cells during experimental psoriasis.

Sun Jul 31 00:00:00 EDT 2016

PD-1 pathway-mediated regulation of islet-specific CD4⁺ T cell subsets in autoimmune diabetes.

Immunoendocrinology (Houston, Tex.)

Martinov T,Spanier JA,Pauken KE,Fife BT

14-0112 was used in Flow cytometry/Cell sorting to understand the role of PD-1 in maintaining islet-specific tolerance in diabetes-resistant strains.

Wed Mar 30 00:00:00 EDT 2022

Diet-dependent, microbiota-independent regulation of IL-10-producing lamina propria macrophages in the small intestine.

Scientific reports

Ochi T,Feng Y,Kitamoto S,Nagao-Kitamoto H,Kuffa P,Atarashi K,Honda K,Teitelbaum DH,Kamada N

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Wed Jun 15 00:00:00 EDT 2016

KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis.

Nature medicine

Shankman LS,Gomez D,Cherepanova OA,Salmon M,Alencar GF,Haskins RM,Swiatlowska P,Newman AA,Greene ES,Straub AC,Isakson B,Randolph GJ,Owens GK

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Mon Jun 01 00:00:00 EDT 2015

Niche-induced cell death and epithelial phagocytosis regulate hair follicle stem cell pool.

Nature

Mesa KR,Rompolas P,Zito G,Myung P,Sun TY,Brown S,Gonzalez DG,Blagoev KB,Haberman AM,Greco V

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunofluorescence

Thu Jun 04 00:00:00 EDT 2015

CXCR3 chemokine receptor enables local CD8(+) T cell migration for the destruction of virus-infected cells.

Immunity

Hickman HD,Reynoso GV,Ngudiankama BF,Cush SS,Gibbs J,Bennink JR,Yewdell JW

14-0112 was used in Flow cytometry/Cell sorting to investigate how CD8(+) T cells locate virus-infected cells within tissues, showing that the CXCR3 chemokine receptor enables migration for the destruction of virus-infected cells.

Tue Mar 17 00:00:00 EDT 2015

CXCR3 chemokine receptor enables local CD8(+) T cell migration for the destruction of virus-infected cells.

Immunity

Hickman HD,Reynoso GV,Ngudiankama BF,Cush SS,Gibbs J,Bennink JR,Yewdell JW

Tue Mar 17 00:00:00 EDT 2015

Host microbiota constantly control maturation and function of microglia in the CNS.

Nature neuroscience

Erny D,Hrabě de Angelis AL,Jaitin D,Wieghofer P,Staszewski O,David E,Keren-Shaul H,Mahlakoiv T,Jakobshagen K,Buch T,Schwierzeck V,Utermöhlen O,Chun E,Garrett WS,McCoy KD,Diefenbach A,Staeheli P,Stecher B,Amit I,Prinz M

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Wed Jul 01 00:00:00 EDT 2015

Functional-genetic dissection of HDAC dependencies in mouse lymphoid and myeloid malignancies.

Blood

Matthews GM,Mehdipour P,Cluse LA,Falkenberg KJ,Wang E,Roth M,Santoro F,Vidacs E,Stanley K,House CM,Rusche JR,Vakoc CR,Zuber J,Minucci S,Johnstone RW

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu Nov 19 00:00:00 EST 2015

Apoptotic cells trigger a membrane-initiated pathway to increase ABCA1.

The Journal of clinical investigation

Fond AM,Lee CS,Schulman IG,Kiss RS,Ravichandran KS

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Wed Jul 01 00:00:00 EDT 2015

MicroRNA-223 is a crucial mediator of PPARγ-regulated alternative macrophage activation.

The Journal of clinical investigation

Ying W,Tseng A,Chang RC,Morin A,Brehm T,Triff K,Nair V,Zhuang G,Song H,Kanameni S,Wang H,Golding MC,Bazer FW,Chapkin RS,Safe S,Zhou B

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Mon Nov 02 00:00:00 EST 2015

Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors.

The Journal of clinical investigation

Henry CJ,Casás-Selves M,Kim J,Zaberezhnyy V,Aghili L,Daniel AE,Jimenez L,Azam T,McNamee EN,Clambey ET,Klawitter J,Serkova NJ,Tan AC,Dinarello CA,DeGregori J

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Dec 01 00:00:00 EST 2015

STK4 regulates TLR pathways and protects against chronic inflammation-related hepatocellular carcinoma.

The Journal of clinical investigation

Li W,Xiao J,Zhou X,Xu M,Hu C,Xu X,Lu Y,Liu C,Xue S,Nie L,Zhang H,Li Z,Zhang Y,Ji F,Hui L,Tao W,Wei B,Wang H

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Mon Nov 02 00:00:00 EST 2015

The Journal of experimental medicine

Rumble JM,Huber AK,Krishnamoorthy G,Srinivasan A,Giles DA,Zhang X,Wang L,Segal BM

14-0112 was used in Flow cytometry/Cell sorting to provide evidence of neutrophil involvement in MS and the animal model EAE, and suggest neutrophil-related molecules as an alternative source of novel biomarkers and therapeutic targets in MS.

Mon Jan 12 00:00:00 EST 2015

TREM-2 promotes macrophage survival and lung disease after respiratory viral infection.

The Journal of experimental medicine

Wu K,Byers DE,Jin X,Agapov E,Alexander-Brett J,Patel AC,Cella M,Gilfilan S,Colonna M,Kober DL,Brett TJ,Holtzman MJ

14-0112 was used in Flow cytometry/Cell sorting to define the link between viral infection and type 2 immune response in chronic respiratory disease, showing that expression of TREM2 in macrophages is required, particularly soluble TREM2, which prevents apoptosis of macrophages and leads to chronic inflammatory disease.

Mon May 04 00:00:00 EDT 2015

Kindlin-3-mediated integrin adhesion is dispensable for quiescent but essential for activated hematopoietic stem cells.

The Journal of experimental medicine

Ruppert R,Moser M,Sperandio M,Rognoni E,Orban M,Liu WH,Schulz AS,Oostendorp RA,Massberg S,Fässler R

14-0112 was used in Flow cytometry/Cell sorting to highlight a role for Kindlin-3 in the control of haematopoietic stem and progenitor cell homing function.

Mon Aug 24 00:00:00 EDT 2015

Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination.

Brain : a journal of neurology

Natrajan MS,de la Fuente AG,Crawford AH,Linehan E,Nuñez V,Johnson KR,Wu T,Fitzgerald DC,Ricote M,Bielekova B,Franklin RJ

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Dec 01 00:00:00 EST 2015

Tamm-Horsfall Protein Regulates Granulopoiesis and Systemic Neutrophil Homeostasis.

Journal of the American Society of Nephrology : JASN

Micanovic R,Chitteti BR,Dagher PC,Srour EF,Khan S,Hato T,Lyle A,Tong Y,Wu XR,El-Achkar TM

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Sep 01 00:00:00 EDT 2015

Cis-regulatory mechanisms governing stem and progenitor cell transitions.

Science advances

Johnson KD,Kong G,Gao X,Chang YI,Hewitt KJ,Sanalkumar R,Prathibha R,Ranheim EA,Dewey CN,Zhang J,Bresnick EH

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Sep 01 00:00:00 EDT 2015

Tristetraprolin Limits Inflammatory Cytokine Production in Tumor-Associated Macrophages in an mRNA Decay-Independent Manner.

Cancer research

Kratochvill F,Gratz N,Qualls JE,Van De Velde LA,Chi H,Kovarik P,Murray PJ

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Western Blot

Sat Aug 01 00:00:00 EDT 2015

The E-Id protein axis modulates the activities of the PI3K-AKT-mTORC1-Hif1a and c-myc/p19Arf pathways to suppress innate variant TFH cell development, thymocyte expansion, and lymphomagenesis.

Genes & development

Miyazaki M,Miyazaki K,Chen S,Chandra V,Wagatsuma K,Agata Y,Rodewald HR,Saito R,Chang AN,Varki N,Kawamoto H,Murre C

14-0112 was used in Flow cytometry/Cell sorting to show that Id2 and Id3 suppress the development and expansion of innate variant follicular helper T cells.

Sun Feb 15 00:00:00 EST 2015

COX/mPGES-1/PGE2 pathway depicts an inflammatory-dependent high-risk neuroblastoma subset.

Proceedings of the National Academy of Sciences of the United States of America

Larsson K,Kock A,Idborg H,Arsenian Henriksson M,Martinsson T,Johnsen JI,Korotkova M,Kogner P,Jakobsson PJ

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunofluorescence

Tue Jun 30 00:00:00 EDT 2015

CD11b regulates obesity-induced insulin resistance via limiting alternative activation and proliferation of adipose tissue macrophages.

Proceedings of the National Academy of Sciences of the United States of America

Zheng C,Yang Q,Xu C,Shou P,Cao J,Jiang M,Chen Q,Cao G,Han Y,Li F,Cao W,Zhang L,Zhang L,Shi Y,Wang Y

14-0112 was used in Blocking experiments to investigate the role of CD11b in obesity-associated inflammation.

Tue Dec 29 00:00:00 EST 2015

PD-1 or PD-L1 Blockade Restores Antitumor Efficacy Following SSX2 Epitope-Modified DNA Vaccine Immunization.

Cancer immunology research

Rekoske BT,Smith HA,Olson BM,Maricque BB,McNeel DG

14-0112 was used in Flow cytometry/Cell sorting to determine that vaccines aimed at eliciting effector CD8(+) T cells may have improved function when combined with PD-1 pathway inhibitors.

Sat Aug 01 00:00:00 EDT 2015

Effect of a broad-specificity chemokine-binding protein on brain leukocyte infiltration and infarct development.

Stroke

Lee S,Chu HX,Kim HA,Real NC,Sharif S,Fleming SB,Mercer AA,Wise LM,Drummond GR,Sobey CG

14-0112 was used in Flow cytometry/Cell sorting to investigate whether post-stroke administration of a chemokine-binding protein, derived from the parapoxvirus bovine papular stomatitis virus, might reduce infiltration of leukocytes into the brain and therefore limit infarct development.

Sun Feb 01 00:00:00 EST 2015

ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells.

PLoS biology

Gallego-Ortega D,Ledger A,Roden DL,Law AM,Magenau A,Kikhtyak Z,Cho C,Allerdice SL,Lee HJ,Valdes-Mora F,Herrmann D,Salomon R,Young AI,Lee BY,Sergio CM,Kaplan W,Piggin C,Conway JR,Rabinovich B,Millar EK,Oakes SR,Chtanova T,Swarbrick A,Naylor MJ,O'Toole S,Green AR,Timpson P,Gee JM,Ellis IO,Clark SJ,Ormandy CJ

14-0112 was used in Flow cytometry/Cell sorting to implicate ELF5 as a defining factor in the acquisition of the key aspects of the lethal phenotype in luminal A breast cancer.

Tue Dec 01 00:00:00 EST 2015

The HIV-1 envelope protein gp120 is captured and displayed for B cell recognition by SIGN-R1(+) lymph node macrophages.

eLife

Park C,Arthos J,Cicala C,Kehrl JH

14-0112 was used in Flow cytometry/Cell sorting to reveal a specialised lymph node antigen delivery system capable of delivering gp120 and other pathogen-derived glycoproteins to B cells.

Mon Aug 10 00:00:00 EDT 2015

IL-1β in eosinophil-mediated small intestinal homeostasis and IgA production.

Mucosal immunology

Jung Y,Wen T,Mingler MK,Caldwell JM,Wang YH,Chaplin DD,Lee EH,Jang MH,Woo SY,Seoh JY,Miyasaka M,Rothenberg ME

14-0112 was used in Flow cytometry/Cell sorting to show that eosinophils are required for mucosal production of IgA and development of Peyer's patches in the gut.

Wed Jul 01 00:00:00 EDT 2015

Granulocytic immune infiltrates are essential for the efficient formation of breast cancer liver metastases.

Breast cancer research : BCR

Tabariès S,Ouellet V,Hsu BE,Annis MG,Rose AA,Meunier L,Carmona E,Tam CE,Mes-Masson AM,Siegel PM

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunohistochemistry

Fri Mar 27 00:00:00 EDT 2015

Identification of a chronic non-neurodegenerative microglia activation state in a mouse model of peroxisomal β-oxidation deficiency.

Glia

Verheijden S,Beckers L,Casazza A,Butovsky O,Mazzone M,Baes M

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Sep 01 00:00:00 EDT 2015

Aging-like changes in the transcriptome of irradiated microglia.

Glia

Li MD,Burns TC,Kumar S,Morgan AA,Sloan SA,Palmer TD

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Fri May 01 00:00:00 EDT 2015

Foxm1 regulates resolution of hyperoxic lung injury in newborns.

American journal of respiratory cell and molecular biology

Xia H,Ren X,Bolte CS,Ustiyan V,Zhang Y,Shah TA,Kalin TV,Whitsett JA,Kalinichenko VV

14-0112 was used in Flow cytometry/Cell sorting to demonstrate that Foxm1 influences pulmonary inflammatory responses to hyperoxia, inhibiting neutrophil-derived enzymes and enhancing monocytic responses that limit alveolar injury and remodeling in neonatal lungs.

Fri May 01 00:00:00 EDT 2015

Helminth Infection and Commensal Microbiota Drive Early IL-10 Production in the Skin by CD4+ T Cells That Are Functionally Suppressive.

PLoS pathogens

Sanin DE,Prendergast CT,Bourke CD,Mountford AP

14-0112 was used in Flow cytometry/Cell sorting to investigate the role of skin CD4+ T cells in immune regulation after repeated pathogen exposure.

Fri May 01 00:00:00 EDT 2015

Helminth Infection and Commensal Microbiota Drive Early IL-10 Production in the Skin by CD4+ T Cells That Are Functionally Suppressive.

PLoS pathogens

Sanin DE,Prendergast CT,Bourke CD,Mountford AP

14-0112 was used in Flow cytometry/Cell sorting to investigate the role of skin CD4+ T cells in immune regulation after repeated pathogen exposure.

Fri May 01 00:00:00 EDT 2015

The neurotrophic receptor Ntrk2 directs lymphoid tissue neovascularization during Leishmania donovani infection.

PLoS pathogens

Dalton JE,Glover AC,Hoodless L,Lim EK,Beattie L,Kirby A,Kaye PM

14-0112 was used in Flow cytometry/Cell sorting to investigate how Ntrk2 plays a role in the pathologic remodeling of the spleen that accompanies chronic infection.

Sun Feb 01 00:00:00 EST 2015

Peptide-MHC-I from Endogenous Antigen Outnumber Those from Exogenous Antigen, Irrespective of APC Phenotype or Activation.

PLoS pathogens

Sei JJ,Haskett S,Kaminsky LW,Lin E,Truckenmiller ME,Bellone CJ,Buller RM,Norbury CC

14-0112 was used in Flow cytometry/Cell sorting to suggest that direct antigen presentation is the dominant pathway in mice during mousepox.

Mon Jun 01 00:00:00 EDT 2015

Differential control of CD4(+) T-cell subsets by the PD-1/PD-L1 axis in a mouse model of allergic asthma.

European journal of immunology

McAlees JW,Lajoie S,Dienger K,Sproles AA,Richgels PK,Yang Y,Khodoun M,Azuma M,Yagita H,Fulkerson PC,Wills-Karp M,Lewkowich IP

14-0112 was used in Flow cytometry/Cell sorting to investigate the role of PD-1 family members in allergic asthma, showing differential control of CD4(+) T-cell subsets by the PD-1/PD-L1 axis.

Wed Apr 01 00:00:00 EDT 2015

Cytokine-Mediated Activation of NK Cells during Viral Infection.

Journal of virology

Freeman BE,Raué HP,Hill AB,Slifka MK

14-0112 was used in Flow cytometry/Cell sorting to study how cytokines interact to regulate natural killer cell function during viral infection.

Sat Aug 01 00:00:00 EDT 2015

The Gut-Associated Lymphoid Tissues in the Small Intestine, Not the Large Intestine, Play a Major Role in Oral Prion Disease Pathogenesis.

Journal of virology

Donaldson DS,Else KJ,Mabbott NA

14-0112 was used in Immunohistochemistry on frozen tissues to demonstrate that the small intestinal GALT are the major early sites of prion accumulation and neuroinvasion after oral exposure in oral prion disease pathogenesis.

Tue Sep 01 00:00:00 EDT 2015

Myeloid heme oxygenase-1 promotes metastatic tumor colonization in mice.

Cancer science

Lin HH,Chiang MT,Chang PC,Chau LY

14-0112 was used in Immunofluorescence to demonstrate that heme oxygenase-1 impacts chemoattractant-induced myeloid cell migration by modulating p38 kinase signaling.

Sun Mar 01 00:00:00 EST 2015

Enhancement of the proapoptotic properties of newcastle disease virus promotes tumor remission in syngeneic murine cancer models.

Molecular cancer therapeutics

Cuadrado-Castano S,Ayllon J,Mansour M,de la Iglesia-Vicente J,Jordan S,Tripathi S,García-Sastre A,Villar E

14-0112 was used in Flow cytometry/Cell sorting to demonstrate an augmented agent for cancer therapy which exploits the oncolytic properties of Newcastle disease virus.

Fri May 01 00:00:00 EDT 2015

Ly6C(high) monocytes control cerebral toxoplasmosis.

Journal of immunology (Baltimore, Md. : 1950)

Biswas A,Bruder D,Wolf SA,Jeron A,Mack M,Heimesaat MM,Dunay IR

14-0112 was used in Flow cytometry/Cell sorting to indicate the critical importance of recruited Ly6C monocytes upon cerebral toxoplasmosis.

Wed Apr 01 00:00:00 EDT 2015

Pak2 Links TCR Signaling Strength to the Development of Regulatory T Cells and Maintains Peripheral Tolerance.

Journal of immunology (Baltimore, Md. : 1950)

O'Hagan KL,Choi J,Pryshchep O,Chernoff J,Phee H

14-0112 was used in Flow cytometry/Cell sorting to show a novel role for the actin cytoskeletal remodeling protein, p21-activated kinase 2, in Treg development and homeostasis.

Sat Aug 15 00:00:00 EDT 2015

Cutting edge: NF-κB p65 and c-Rel control epidermal development and immune homeostasis in the skin.

Journal of immunology (Baltimore, Md. : 1950)

Grinberg-Bleyer Y,Dainichi T,Oh H,Heise N,Klein U,Schmid RM,Hayden MS,Ghosh S

14-0112-82 was used in Flow Cytometry to analyse the function of canonical NF-κB in the epidermis using CRE-mediated deletion of p65 and c-Rel in keratinocytes.

Sun Mar 15 00:00:00 EDT 2015

Haploinsufficiency for Stard7 is associated with enhanced allergic responses in lung and skin.

Journal of immunology (Baltimore, Md. : 1950)

Yang L,Lewkowich I,Apsley K,Fritz JM,Wills-Karp M,Weaver TE

14-0112 was used in Flow cytometry/Cell sorting to determine whether loss of Stard7 expression promotes allergic responses, showing that haploinsufficiency for Stard7 is associated with enhanced allergic responses.

Mon Jun 15 00:00:00 EDT 2015

Canonical wnt signaling in dendritic cells regulates Th1/Th17 responses and suppresses autoimmune neuroinflammation.

Journal of immunology (Baltimore, Md. : 1950)

Suryawanshi A,Manoharan I,Hong Y,Swafford D,Majumdar T,Taketo MM,Manicassamy B,Koni PA,Thangaraju M,Sun Z,Mellor AL,Munn DH,Manicassamy S

14-0112 was used in Flow cytometry/Cell sorting to study the factors in the tissue microenvironment and signalling networks critical for programming dendritic cells to control chronic inflammation and promote tolerance, showing that Th1/Th17 responses are regulated by canonical Wnt signalling in dendritic cells and suppresses autoimmune neuroinflammation.

Wed Apr 01 00:00:00 EDT 2015

Syk tyrosine kinase is critical for B cell antibody responses and memory B cell survival.

Journal of immunology (Baltimore, Md. : 1950)

Ackermann JA,Nys J,Schweighoffer E,McCleary S,Smithers N,Tybulewicz VL

14-0112 was used in Flow cytometry/Cell sorting to define the contribution of Syk to B cell function.

Fri May 15 00:00:00 EDT 2015

Inhibition of System Xc(-) Transporter Attenuates Autoimmune Inflammatory Demyelination.

Journal of immunology (Baltimore, Md. : 1950)

Evonuk KS,Baker BJ,Doyle RE,Moseley CE,Sestero CM,Johnston BP,De Sarno P,Tang A,Gembitsky I,Hewett SJ,Weaver CT,Raman C,DeSilva TM

14-0112 was used in Flow cytometry/Cell sorting to investigate the link between inflammation and glutamate dysregulation in EAE, showing that inhibition of system Xc(-) transporter attenuates autoimmune inflammatory demyelination.

Wed Jul 15 00:00:00 EDT 2015

The B subunit of Escherichia coli heat-labile toxin alters the development and antigen-presenting capacity of dendritic cells.

Journal of cellular and molecular medicine

Ji J,Griffiths KL,Milburn PJ,Hirst TR,O'Neill HC

14-0112 was used in Magnetic cell separation to investigate the direct effect of intravenously administered EtxB on the size of the dendritic and myeloid cell populations in spleen.

Sat Aug 01 00:00:00 EDT 2015

Identifying panaxynol, a natural activator of nuclear factor erythroid-2 related factor 2 (Nrf2) from American ginseng as a suppressor of inflamed macrophage-induced cardiomyocyte hypertrophy.

Journal of ethnopharmacology

Qu C,Li B,Lai Y,Li H,Windust A,Hofseth LJ,Nagarkatti M,Nagarkatti P,Wang XL,Tang D,Janicki JS,Tian X,Cui T

14-0112 was used in Flow cytometry/Cell sorting to demonstrate that panaxynol-activated Nrf2 signalling is at least partly responsible for American ginseng-induced health benefit in the heart.

Sat Jun 20 00:00:00 EDT 2015

Piliation of Lactobacillus rhamnosus GG promotes adhesion, phagocytosis, and cytokine modulation in macrophages.

Applied and environmental microbiology

Vargas García CE,Petrova M,Claes IJ,De Boeck I,Verhoeven TL,Dilissen E,von Ossowski I,Palva A,Bullens DM,Vanderleyden J,Lebeer S

14-0112 was used in Blocking experiments to investigate the role of the SpaCBA pilus of L. rhamnosus GG in the interaction with macrophages in vitro by comparing the wild type with surface mutants.

Sun Mar 01 00:00:00 EST 2015

Local delivery of VEGF and SDF enhances endothelial progenitor cell recruitment and resultant recovery from ischemia.

Tissue engineering. Part A

Anderson EM,Kwee BJ,Lewin SA,Raimondo T,Mehta M,Mooney DJ

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Wed Apr 01 00:00:00 EDT 2015

IL-18 contributes to susceptibility to Leishmania amazonensis infection by macrophage-independent mechanisms.

Cytokine

Sousa LM,Carneiro MB,Dos Santos LM,Natale CC,Resende ME,Mosser DM,Vieira LQ

14-0112 was used in Flow cytometry/Cell sorting to investigate whether or not macrophages are involved in IL-18-mediated susceptibility to L. amazonensis.

Sat Aug 01 00:00:00 EDT 2015

Regulatory CD8(+)CD122 (+) T-cells predominate in CNS after treatment of experimental stroke in male mice with IL-10-secreting B-cells.

Metabolic brain disease

Bodhankar S,Chen Y,Lapato A,Vandenbark AA,Murphy SJ,Saugstad JA,Offner H

14-0112 was used in Flow cytometry/Cell sorting to demonstrate a major neuroprotective role for IL-10(+) B-cells in treating MCAO in male WT mice.

Sat Aug 01 00:00:00 EDT 2015

Intracellular Listeria monocytogenes comprises a minimal but vital fraction of the intestinal burden following foodborne infection.

Infection and immunity

Jones GS,Bussell KM,Myers-Morales T,Fieldhouse AM,Bou Ghanem EN,D'Orazio SE

14-0112 was used in Flow cytometry/Cell sorting to investigate how mouse-adapted and wild-type L. monocytogenes strains spread to the mesenteric lymph nodes in a foodborne model of listeriosis.

Sat Aug 01 00:00:00 EDT 2015

Reducing progression of experimental lupus nephritis via inhibition of the B7/CD28 signaling pathway.

Molecular medicine reports

Huang L,Kong Y,Wang J,Sun J,Shi Q,Qiu YH

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Sep 01 00:00:00 EDT 2015

Targeted Mutation of Nuclear Bone Morphogenetic Protein 2 Impairs Secondary Immune Response in a Mouse Model.

BioMed research international

Olsen DS,Goar WA,Nichols BA,Bailey KT,Christensen SL,Merriam KR,Reynolds PR,Wilson E,Weber KS,Bridgewater LC

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Mon Aug 01 00:00:00 EDT 2016

Mesenchymal stem cells can prevent alterations in behavior and neurogenesis induced by Aß25-35 administration.

Journal of molecular neuroscience : MN

Hamisha KN,Tfilin M,Yanai J,Turgeman G

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunofluorescence

Wed Apr 01 00:00:00 EDT 2015

Pathogenic Yersinia Promotes Its Survival by Creating an Acidic Fluid-Accessible Compartment on the Macrophage Surface.

PloS one

Bahnan W,Boettner DR,Westermark L,Fällman M,Schesser K

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue May 10 00:00:00 EDT 2016

Pathogenic Yersinia Promotes Its Survival by Creating an Acidic Fluid-Accessible Compartment on the Macrophage Surface.

PloS one

Bahnan W,Boettner DR,Westermark L,Fällman M,Schesser K

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue May 10 00:00:00 EDT 2016

Memory T cells generated by prior exposure to influenza cross react with the novel H7N9 influenza virus and confer protective heterosubtypic immunity.

PloS one

McMaster SR,Gabbard JD,Koutsonanos DG,Compans RW,Tripp RA,Tompkins SM,Kohlmeier JE

14-0112 was used in Flow cytometry/Cell sorting to quantify the H7N9 cross-reactive memory T cell reservoir in humans and mice previously exposed to common circulating influenza viruses.

Tue Jan 19 00:00:00 EST 2016

Granulocyte/Macrophage Colony-stimulating Factor-dependent Dendritic Cells Restrain Lean Adipose Tissue Expansion.

The Journal of biological chemistry

Pamir N,Liu NC,Irwin A,Becker L,Peng Y,Ronsein GE,Bornfeldt KE,Duffield JS,Heinecke JW

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Fri Jun 05 00:00:00 EDT 2015

Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation.

Nature communications

Ryu JK,Petersen MA,Murray SG,Baeten KM,Meyer-Franke A,Chan JP,Vagena E,Bedard C,Machado MR,Rios Coronado PE,Prod'homme T,Charo IF,Lassmann H,Degen JL,Zamvil SS,Akassoglou K

14-0112 was used in Functional assays to investigate the mechanisms that drive immunological responses targeted to the CNS.

Thu Sep 10 00:00:00 EDT 2015

The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia.

Nature communications

Koh HS,Chang CY,Jeon SB,Yoon HJ,Ahn YH,Kim HS,Kim IH,Jeon SH,Johnson RS,Park EJ

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Fri Mar 20 00:00:00 EDT 2015

Small-molecule inhibitors targeting INK4 protein p18(INK4C) enhance ex vivo expansion of haematopoietic stem cells.

Nature communications

Gao Y,Yang P,Shen H,Yu H,Song X,Zhang L,Zhang P,Cheng H,Xie Z,Hao S,Dong F,Ma S,Ji Q,Bartlow P,Ding Y,Wang L,Liu H,Li Y,Cheng H,Miao W,Yuan W,Yuan Y,Cheng T,Xie XQ

14-0112 was used in Flow cytometry/Cell sorting to investigate how putative small-molecule inhibitors for p18 protein are valuable for further dissecting the signalling pathways of stem cell self-renewal.

Wed Feb 18 00:00:00 EST 2015

Evaluation of the BDCA2-DTR Transgenic Mouse Model in Chronic and Acute Inflammation.

PloS one

Mandl M,Drechsler M,Jansen Y,Neideck C,Noels H,Faussner A,Soehnlein O,Weber C,Döring Y

14-0112 was used in Flow cytometry/Cell sorting to investigate how continuous diphtheria toxin-induced pDC depletion in Apoe-/- BDCA2-DTR mice receiving a high-fat diet (HFD) for 4 weeks did not alter lesion size or composition.

Sun May 08 00:00:00 EDT 2016

Cancer-associated ASXL1 mutations may act as gain-of-function mutations of the ASXL1-BAP1 complex.

Nature communications

Balasubramani A,Larjo A,Bassein JA,Chang X,Hastie RB,Togher SM,Lähdesmäki H,Rao A

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Mon Jun 22 00:00:00 EDT 2015

Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and highly express Gpnmb and Spp1.

PloS one

Szulzewsky F,Pelz A,Feng X,Synowitz M,Markovic D,Langmann T,Holtman IR,Wang X,Eggen BJ,Boddeke HW,Hambardzumyan D,Wolf SA,Kettenmann H

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Jan 12 00:00:00 EST 2016

dNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis.

Nature communications

Lim S,Kim WJ,Kim YH,Lee S,Koo JH,Lee JA,Yoon H,Kim DH,Park HJ,Kim HM,Lee HG,Yun Kim J,Lee JU,Hun Shin J,Kyun Kim L,Doh J,Kim H,Lee SK,Bothwell ALM,Suh M,Choi JM

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Sep 15 00:00:00 EDT 2015

CCR7-dependent trafficking of RORγ⁺ ILCs creates a unique microenvironment within mucosal draining lymph nodes.

Nature communications

Mackley EC,Houston S,Marriott CL,Halford EE,Lucas B,Cerovic V,Filbey KJ,Maizels RM,Hepworth MR,Sonnenberg GF,Milling S,Withers DR

14-0112 was used in Flow cytometry/Cell sorting to investigate whether group 3 innate lymphoid cells migrate from their mucosal and peripheral sites to local draining secondary lymphoid tissues.

Fri Jan 09 00:00:00 EST 2015

Targeted Gene Correction in Osteopetrotic-Induced Pluripotent Stem Cells for the Generation of Functional Osteoclasts.

Stem cell reports

Neri T,Muggeo S,Paulis M,Caldana ME,Crisafulli L,Strina D,Focarelli ML,Faggioli F,Recordati C,Scaramuzza S,Scanziani E,Mantero S,Buracchi C,Sobacchi C,Lombardo A,Naldini L,Vezzoni P,Villa A,Ficara F

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Oct 13 00:00:00 EDT 2015

Splenic red pulp macrophages are intrinsically superparamagnetic and contaminate magnetic cell isolates.

Scientific reports

Franken L,Klein M,Spasova M,Elsukova A,Wiedwald U,Welz M,Knolle P,Farle M,Limmer A,Kurts C

14-0112 was used in Flow cytometry/Cell sorting to elucidate the intrinsic superparamagnetic nature of splenic red pulp macrophages and their effect on magnetic cell isolates.

Tue Aug 11 00:00:00 EDT 2015

Soluble NKG2D ligand promotes MDSC expansion and skews macrophage to the alternatively activated phenotype.

Journal of hematology & oncology

Xiao G,Wang X,Sheng J,Lu S,Yu X,Wu JD

14-0112 was used in Flow cytometry/Cell sorting to report a novel mechanism by which soluble MIC imposes an immunosuppressive effect on host immunity and the tumour microenvironment.

Fri Feb 20 00:00:00 EST 2015

Histamine deficiency promotes accumulation of immunosuppressive immature myeloid cells and growth of murine gliomas.

Oncoimmunology

Ahn B,Kohanbash G,Ohkuri T,Kosaka A,Chen X,Ikeura M,Wang TC,Okada H

14-0112 was used in Flow cytometry/Cell sorting to investigate the role of HDC in the glioma microenvironment via maturation of myeloid cells and resulting activation of CD8(+) T cells.

Sun Nov 01 00:00:00 EDT 2015

Deficient Natural Killer Dendritic Cell Responses Underlay the Induction of Theiler's Virus-Induced Autoimmunity.

mBio

Chastain EM,Getts DR,Miller SD

14-0112 was used in Flow cytometry/Cell sorting to determine that disease-susceptible SJL/J mice lacked a unique innate immune population, which plays a role in early CNS virus clearance.

Tue Aug 04 00:00:00 EDT 2015

Anti-Inflammatory Effects of IL-27 in Zymosan-Induced Peritonitis: Inhibition of Neutrophil Recruitment Partially Explained by Impaired Mobilization from Bone Marrow and Reduced Chemokine Levels.

PloS one

Watzlawick R,Kenngott EE,Liu FD,Schwab JM,Hamann A

14-0112 was used in Flow cytometry/Cell sorting to determine the role of IL-27 in innate immune responses.

Tue May 24 00:00:00 EDT 2016

Aquaporin-9-expressing neutrophils are required for the establishment of contact hypersensitivity.

Scientific reports

Moniaga CS,Watanabe S,Honda T,Nielsen S,Hara-Chikuma M

14-0112 was used in Flow cytometry/Cell sorting to suggest that AQP9 is required for the development of sensitisation during cutaneous acquired immune responses via regulating neutrophil function.

Thu Oct 22 00:00:00 EDT 2015

Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction.

Nature communications

Rouhani SJ,Eccles JD,Riccardi P,Peske JD,Tewalt EF,Cohen JN,Liblau R,Mäkinen T,Engelhard VH

14-0112 was used in Flow cytometry/Cell sorting to demonstrate that when β-galactosidase (β-gal) is expressed in LECs, β-gal-specific CD8 T cells undergo deletion via the PD-1/PD-L1 and LAG-3/MHC-II pathways.

Fri Apr 10 00:00:00 EDT 2015

Disease severity and mortality can be independently regulated in a mouse model of experimental graft versus host disease.

PloS one

Galvani RG,Lemos R,Areal RB,Salvador PA,Zamboni DS,Wanderley JL,Bonomo A

14-0112 was used in Magnetic cell separation to investigate the exact cause of death in graft versus host disease, showing that disease severity and mortality can be independently regulated.

Mon Oct 19 00:00:00 EDT 2015

Sunitinib depletes myeloid-derived suppressor cells and synergizes with a cancer vaccine to enhance antigen-specific immune responses and tumor eradication.

Oncoimmunology

Draghiciu O,Nijman HW,Hoogeboom BN,Meijerhof T,Daemen T

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Sun Mar 01 00:00:00 EST 2015

Alendronate inhalation ameliorates elastase-induced pulmonary emphysema in mice by induction of apoptosis of alveolar macrophages.

Nature communications

Ueno M,Maeno T,Nishimura S,Ogata F,Masubuchi H,Hara K,Yamaguchi K,Aoki F,Suga T,Nagai R,Kurabayashi M

14-0112 was used in Flow cytometry/Cell sorting to demonstrate the therapeutic potential of alendronate administration for the treatment of emphysema.

Tue Mar 10 00:00:00 EDT 2015

Dendritic Cell Protection from Cisplatin Nephrotoxicity Is Independent of Neutrophils.

Toxins

Tadagavadi RK,Gao G,Wang WW,Gonzalez MR,Reeves WB

14-0112 was used in Flow cytometry/Cell sorting to investigate the kinetics of neutrophil infiltration into kidneys and their role in cisplatin-mediated acute kidney injury.

Wed Aug 19 00:00:00 EDT 2015

Latent virus infection upregulates CD40 expression facilitating enhanced autoimmunity in a model of multiple sclerosis.

Scientific reports

Casiraghi C,Márquez AC,Shanina I,Horwitz MS

14-0112 was used in Flow cytometry/Cell sorting to investigate the cause of enhanced experimental autoimmune encephalomyelitis following infection with murine γ-herpesvirus 68.

Thu Sep 10 00:00:00 EDT 2015

Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity.

Nature

Westphalen K,Gusarova GA,Islam MN,Subramanian M,Cohen TS,Prince AS,Bhattacharya J

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunofluorescence

Thu Feb 27 00:00:00 EST 2014

RNA viruses can hijack vertebrate microRNAs to suppress innate immunity.

Nature

Trobaugh DW,Gardner CL,Sun C,Haddow AD,Wang E,Chapnik E,Mildner A,Weaver SC,Ryman KD,Klimstra WB

14-0112 was used in Immunocytochemistry to study the mechanism by which haematopoietic-cell-specific miR-142-3p potently restricts the replication of the mosquito-borne North American eastern equine encephalitis virus in myeloid-lineage cells.

Thu Feb 13 00:00:00 EST 2014

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid.

Nature

Colegio OR,Chu NQ,Szabo AL,Chu T,Rhebergen AM,Jairam V,Cyrus N,Brokowski CE,Eisenbarth SC,Phillips GM,Cline GW,Phillips AJ,Medzhitov R

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu Sep 25 00:00:00 EDT 2014

Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages.

Cell

Haldar M,Kohyama M,So AY,Kc W,Wu X,Briseño CG,Satpathy AT,Kretzer NM,Arase H,Rajasekaran NS,Wang L,Egawa T,Igarashi K,Baltimore D,Murphy TL,Murphy KM

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu Mar 13 00:00:00 EDT 2014

Adenylyl cyclase-associated protein 1 is a receptor for human resistin and mediates inflammatory actions of human monocytes.

Cell metabolism

Lee S,Lee HC,Kwon YW,Lee SE,Cho Y,Kim J,Lee S,Kim JY,Lee J,Yang HM,Mook-Jung I,Nam KY,Chung J,Lazar MA,Kim HS

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunohistochemistry

Tue Mar 04 00:00:00 EST 2014

Reducing macrophage proteoglycan sulfation increases atherosclerosis and obesity through enhanced type I interferon signaling.

Cell metabolism

Gordts PLSM,Foley EM,Lawrence R,Sinha R,Lameda-Diaz C,Deng L,Nock R,Glass CK,Erbilgin A,Lusis AJ,Witztum JL,Esko JD

14-0112 was used in Flow cytometry/Cell sorting to investigate the role of heparan sulfate proteoglycans in atherogenesis, showing that reducing macrophage proteoglycan sulfation increases atherosclerosis and obesity.

Tue Nov 04 00:00:00 EST 2014

A role for the ITAM signaling module in specifying cytokine-receptor functions.

Nature immunology

Bezbradica JS,Rosenstein RK,DeMarco RA,Brodsky I,Medzhitov R

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Apr 01 00:00:00 EDT 2014

Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages.

Nature immunology

Huang SC,Everts B,Ivanova Y,O'Sullivan D,Nascimento M,Smith AM,Beatty W,Love-Gregory L,Lam WY,O'Neill CM,Yan C,Du H,Abumrad NA,Urban JF,Artyomov MN,Pearce EL,Pearce EJ

14-0112 was used in Flow cytometry/Cell sorting to delineate a critical role for cell-intrinsic lysosomal lipolysis in M2 activation.

Mon Sep 01 00:00:00 EDT 2014

The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses.

Nature immunology

Khare S,Ratsimandresy RA,de Almeida L,Cuda CM,Rellick SL,Misharin AV,Wallin MC,Gangopadhyay A,Forte E,Gottwein E,Perlman H,Reed JC,Greaves DR,Dorfleutner A,Stehlik C

14-0112 was used in Flow cytometry/Cell sorting to study the molecular mechanisms regulating the activation of the innate immune response to viral DNA.

Tue Apr 01 00:00:00 EDT 2014

In utero depletion of fetal hematopoietic stem cells improves engraftment after neonatal transplantation in mice.

Blood

Derderian SC,Togarrati PP,King C,Moradi PW,Reynaud D,Czechowicz A,Weissman IL,MacKenzie TC

14-0112 was used in Flow cytometry/Cell sorting to develop a successful foetal conditioning strategy associated with minimal toxicity.

Thu Aug 07 00:00:00 EDT 2014

Atm deletion with dual recombinase technology preferentially radiosensitizes tumor endothelium.

The Journal of clinical investigation

Moding EJ,Lee CL,Castle KD,Oh P,Mao L,Zha S,Min HD,Ma Y,Das S,Kirsch DG

14-0112 was used in Immunofluorescence to determine that endothelial cells must progress through the cell cycle in order to be radiosensitized by Atm deletion.

Fri Aug 01 00:00:00 EDT 2014

Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm.

The Journal of clinical investigation

Kong G,Wunderlich M,Yang D,Ranheim EA,Young KH,Wang J,Chang YI,Du J,Liu Y,Tey SR,Zhang X,Juckett M,Mattison R,Damnernsawad A,Zhang J,Mulloy JC,Zhang J

14-0112 was used in Flow cytometry/Cell sorting to investigate the effect of combined targeting of MEK/ERK and JAK/STAT signalling on the murine myeloproliferative neoplasm.

Sun Jun 01 00:00:00 EDT 2014

Intrinsic TGF-β signaling promotes age-dependent CD8+ T cell polyfunctionality attrition.

The Journal of clinical investigation

Bhadra R,Moretto MM,Castillo JC,Petrovas C,Ferrando-Martinez S,Shokal U,Leal M,Koup RA,Eleftherianos I,Khan IA

14-0112 was used in Flow cytometry/Cell sorting to investigate the progressive loss of CD8+ T cell polyfunctionality during aging, using animals challenged with the obligate intracellular pathogen Encephalitozoon cuniculi.

Sun Jun 01 00:00:00 EDT 2014

Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection.

The Journal of experimental medicine

Penaloza-MacMaster P,Kamphorst AO,Wieland A,Araki K,Iyer SS,West EE,O'Mara L,Yang S,Konieczny BT,Sharpe AH,Freeman GJ,Rudensky AY,Ahmed R

14-0112 was used in Flow cytometry/Cell sorting to investigate a role for T reg cells in exhaustion of virus-specific CD8 T cells.

Mon Aug 25 00:00:00 EDT 2014

The transcription factor E4bp4/Nfil3 controls commitment to the NK lineage and directly regulates Eomes and Id2 expression.

The Journal of experimental medicine

Male V,Nisoli I,Kostrzewski T,Allan DS,Carlyle JR,Lord GM,Wack A,Brady HJ

14-0112 was used in Flow cytometry/Cell sorting to propose that E4bp4 is required for commitment to the NK lineage and can promote NK development by directly regulating the expression of the downstream transcription factors Eomes and Id2.

Mon Apr 07 00:00:00 EDT 2014

Selective and strain-specific NFAT4 activation by the Toxoplasma gondii polymorphic dense granule protein GRA6.

The Journal of experimental medicine

Ma JS,Sasai M,Ohshima J,Lee Y,Bando H,Takeda K,Yamamoto M

14-0112 was used in Flow cytometry/Cell sorting to suggest that GRA6-dependent NFAT4 activation is required for Toxoplasma gondii manipulation of host immune responses.

Mon Sep 22 00:00:00 EDT 2014

Cardiac fibroblasts mediate IL-17A-driven inflammatory dilated cardiomyopathy.

The Journal of experimental medicine

Wu L,Ong S,Talor MV,Barin JG,Baldeviano GC,Kass DA,Bedja D,Zhang H,Sheikh A,Margolick JB,Iwakura Y,Rose NR,Ciháková D

14-0112 was used in Immunofluorescence to show a novel pathway connecting IL-17A, cardiac fibroblasts, GM-CSF, and heart-infiltrating myeloid cells with the pathogenesis of DCMi.

Mon Jun 30 00:00:00 EDT 2014

Progressive replacement of embryo-derived cardiac macrophages with age.

The Journal of experimental medicine

Molawi K,Wolf Y,Kandalla PK,Favret J,Hagemeyer N,Frenzel K,Pinto AR,Klapproth K,Henri S,Malissen B,Rodewald HR,Rosenthal NA,Bajenoff M,Prinz M,Jung S,Sieweke MH

14-0112 was used in Flow cytometry/Cell sorting to report that the embryo-derived population of cardiac macrophages is progressively substituted for monocyte-derived macrophages within the first weeks after birth.

Mon Oct 20 00:00:00 EDT 2014

Modulation of leukocyte infiltration and phenotype in microporous tissue engineering scaffolds via vector induced IL-10 expression.

Biomaterials

Gower RM,Boehler RM,Azarin SM,Ricci CF,Leonard JN,Shea LD

14-0112 was used in Flow cytometry/Cell sorting to investigate if lentiviral IL-10 gene delivery can reduce inflammation following biomaterial implantation.

Sat Feb 01 00:00:00 EST 2014

Macrophages and β-cells are responsible for CXCR2-mediated neutrophil infiltration of the pancreas during autoimmune diabetes.

EMBO molecular medicine

Diana J,Lehuen A

14-0112 was used in Flow cytometry/Cell sorting to determine the cellular and molecular mechanisms leading to the recruitment of neutrophils in the pancreatic islets of non-obese diabetic mice.

Fri Aug 01 00:00:00 EDT 2014

Small molecule-driven mitophagy-mediated NLRP3 inflammasome inhibition is responsible for the prevention of colitis-associated cancer.

Autophagy

Guo W,Sun Y,Liu W,Wu X,Guo L,Cai P,Wu X,Wu X,Shen Y,Shu Y,Gu Y,Xu Q

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunofluorescence

Sun Jun 01 00:00:00 EDT 2014

RAGE expression in tumor-associated macrophages promotes angiogenesis in glioma.

Cancer research

Chen X,Zhang L,Zhang IY,Liang J,Wang H,Ouyang M,Wu S,da Fonseca ACC,Weng L,Yamamoto Y,Yamamoto H,Natarajan R,Badie B

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Mon Dec 15 00:00:00 EST 2014

Immune-based antitumor effects of BRAF inhibitors rely on signaling by CD40L and IFNγ.

Cancer research

Ho PC,Meeth KM,Tsui YC,Srivastava B,Bosenberg MW,Kaech SM

14-0112 was used in Flow cytometry/Cell sorting to investigate whether B-Raf(V600E) inhibitors promote tumor regression with the help of host immunity, showing that they rely on signaling by CD40L and IFNγ.

Sun Jun 15 00:00:00 EDT 2014

Murine CD27(-) Vγ6(+) γδ T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages.

Proceedings of the National Academy of Sciences of the United States of America

Rei M,Gonçalves-Sousa N,Lança T,Thompson RG,Mensurado S,Balkwill FR,Kulbe H,Pennington DJ,Silva-Santos B

14-0112 was used in Flow cytometry/Cell sorting to characterise the role of tumour-associated γδ T cells on disease development using a model peritoneal/ovarian cancer cell line.

Tue Aug 26 00:00:00 EDT 2014

Disruption of the immune-checkpoint VISTA gene imparts a proinflammatory phenotype with predisposition to the development of autoimmunity.

Proceedings of the National Academy of Sciences of the United States of America

Wang L,Le Mercier I,Putra J,Chen W,Liu J,Schenk AD,Nowak EC,Suriawinata AA,Li J,Noelle RJ

14-0112 was used in Flow cytometry/Cell sorting to study the effect of VISTA genetic deficiency on T-cell-mediated inflammation, showing that the threshold for activation was lowered and that there was increased susceptibility to autoimmunity.

Tue Oct 14 00:00:00 EDT 2014

Macrophages contribute to the cyclic activation of adult hair follicle stem cells.

PLoS biology

Castellana D,Paus R,Perez-Moreno M

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Mon Dec 01 00:00:00 EST 2014

Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNFα in glioblastoma.

Science signaling

Kusne Y,Carrera-Silva EA,Perry AS,Rushing EJ,Mandell EK,Dietrich JD,Errasti AE,Gibbs D,Berens ME,Loftus JC,Hulme C,Yang W,Lu Z,Aldape K,Sanai N,Rothlin CV,Ghosh S

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunohistochemistry

Tue Aug 12 00:00:00 EDT 2014

Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNFα in glioblastoma.

Science signaling

Kusne Y,Carrera-Silva EA,Perry AS,Rushing EJ,Mandell EK,Dietrich JD,Errasti AE,Gibbs D,Berens ME,Loftus JC,Hulme C,Yang W,Lu Z,Aldape K,Sanai N,Rothlin CV,Ghosh S

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunohistochemistry

Tue Aug 12 00:00:00 EDT 2014

Dietary supplementation with high doses of regular vitamin D3 safely reduces diabetes incidence in NOD mice when given early and long term.

Diabetes

Takiishi T,Ding L,Baeke F,Spagnuolo I,Sebastiani G,Laureys J,Verstuyf A,Carmeliet G,Dotta F,Van Belle TL,Gysemans CA,Mathieu C

14-0112 was used in Flow cytometry/Cell sorting to investigate the effect of vitamin D3 administration during different periods of life on diabetes prevention in NOD mice.

Sun Jun 01 00:00:00 EDT 2014

Distinct progenitor origin distinguishes a lineage of dendritic-like cells in spleen.

Frontiers in immunology

Petvises S,O'Neill HC

14-0112 was used in Flow cytometry/Cell sorting to study how a lineage of dendritic-like cells in the spleen are distinguished by distinct progenitor origins.

Wed Jan 15 00:00:00 EST 2014

Astrocytic transforming growth factor-beta signaling reduces subacute neuroinflammation after stroke in mice.

Glia

Cekanaviciute E,Fathali N,Doyle KP,Williams AM,Han J,Buckwalter MS

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Fri Aug 01 00:00:00 EDT 2014

Central memory CD4+ T cells are responsible for the recombinant Bacillus Calmette-Guérin ΔureC::hly vaccine's superior protection against tuberculosis.

The Journal of infectious diseases

Vogelzang A,Perdomo C,Zedler U,Kuhlmann S,Hurwitz R,Gengenbacher M,Kaufmann SH

14-0112 was used in Flow cytometry/Cell sorting to investigate the T-cell population required for recombinant Bacillus Calmette-Guérin δureC::hly vaccine's enhanced protection against tuberculosis.

Mon Dec 15 00:00:00 EST 2014

Inhibition of the TRAIL death receptor by CMV reveals its importance in NK cell-mediated antiviral defense.

PLoS pathogens

Verma S,Loewendorf A,Wang Q,McDonald B,Redwood A,Benedict CA

14-0112 was used in Flow cytometry/Cell sorting to highlight the critical importance for CMV to have evolved a strategy to inhibit TRAIL-DR signaling to thwart NK-mediated defenses.

Fri Aug 01 00:00:00 EDT 2014

Syk signaling in dendritic cells orchestrates innate resistance to systemic fungal infection.

PLoS pathogens

Whitney PG,Bär E,Osorio F,Rogers NC,Schraml BU,Deddouche S,LeibundGut-Landmann S,Reis e Sousa C

14-0112 was used in Flow cytometry/Cell sorting to study the contribution of a specific signalling pathway involved in fungal recognition by dendritic cells during immune responses to fungal pathogens.

Tue Jul 01 00:00:00 EDT 2014

Syk signaling in dendritic cells orchestrates innate resistance to systemic fungal infection.

PLoS pathogens

Whitney PG,Bär E,Osorio F,Rogers NC,Schraml BU,Deddouche S,LeibundGut-Landmann S,Reis e Sousa C

Tue Jul 01 00:00:00 EDT 2014

Sepsis-induced potentiation of peritoneal macrophage migration is mitigated by programmed cell death receptor-1 gene deficiency.

Journal of innate immunity

Ayala A,Elphick GF,Kim YS,Huang X,Carreira-Rosario A,Santos SC,Shubin NJ,Chen Y,Reichner J,Chung CS

14-0112 was used in Flow cytometry/Cell sorting to investigate the effect of programmed cell death receptor-1 in mediating aspects of innate macrophage immune dysfunction during sepsis.

Mon May 11 00:00:00 EDT 2015

A crucial role for the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification.

Development (Cambridge, England)

Gilmour J,Assi SA,Jaegle U,Kulu D,van de Werken H,Clarke D,Westhead DR,Philipsen S,Bonifer C

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Sun Jun 01 00:00:00 EDT 2014

Dorsal raphe neuroinflammation promotes dramatic behavioral stress dysregulation.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Howerton AR,Roland AV,Bale TL

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunofluorescence

Wed May 21 00:00:00 EDT 2014

Few Foxp3⁺ regulatory T cells are sufficient to protect adult mice from lethal autoimmunity.

European journal of immunology

Mayer CT,Ghorbani P,Kühl AA,Stüve P,Hegemann M,Berod L,Gershwin ME,Sparwasser T

14-0112 was used in Flow cytometry/Cell sorting to study the mechanisms underlying why regulatory T cell-depletion fails to cause autoimmunity in adult Depletion of REGulatory T cells mice.

Wed Oct 01 00:00:00 EDT 2014

MyD88-dependent immunity to a natural model of vaccinia virus infection does not involve Toll-like receptor 2.

Journal of virology

Davies ML,Sei JJ,Siciliano NA,Xu RH,Roscoe F,Sigal LJ,Eisenlohr LC,Norbury CC

14-0112 was used in Flow cytometry/Cell sorting to investigate the ability of the innate sensing molecule Toll-like receptor 2 and the signalling molecule MyD88 to influence the innate and adaptive immune response to vaccinia virus following systemic or dermal infection.

Sat Mar 01 00:00:00 EST 2014

Bleomycin delivery by osmotic minipump: similarity to human scleroderma interstitial lung disease.

American journal of physiology. Lung cellular and molecular physiology

Lee R,Reese C,Bonner M,Tourkina E,Hajdu Z,Riemer EC,Silver RM,Visconti RP,Hoffman S

14-0112 was used in Immunohistochemistry to compare different methods to delivering bleomycin to the lungs of mice to create an effective model of scleroderma interstitial lung disease.

Tue Apr 15 00:00:00 EDT 2014

Bleomycin delivery by osmotic minipump: similarity to human scleroderma interstitial lung disease.

American journal of physiology. Lung cellular and molecular physiology

Lee R,Reese C,Bonner M,Tourkina E,Hajdu Z,Riemer EC,Silver RM,Visconti RP,Hoffman S

14-0112 was used in Immunohistochemistry to compare different methods to delivering bleomycin to the lungs of mice to create an effective model of scleroderma interstitial lung disease.

Tue Apr 15 00:00:00 EDT 2014

Neutrophils mediate edema formation but not mechanical allodynia during zymosan-induced inflammation.

Journal of leukocyte biology

Suo J,Linke B,Meyer dos Santos S,Pierre S,Stegner D,Zhang DD,Denis CV,Geisslinger G,Nieswandt B,Scholich K

14-0112 was used in Blocking experiments to study the contribution of neutrophils to zymosan-induced inflammatory pain.

Tue Jul 01 00:00:00 EDT 2014

Internalization and TLR-dependent type I interferon production by monocytes in response to Toxoplasma gondii.

Immunology and cell biology

Han SJ,Melichar HJ,Coombes JL,Chan SW,Koshy AA,Boothroyd JC,Barton GM,Robey EA

14-0112 was used in Flow cytometry/Cell sorting to show that inflammatory monocytes, but not neutrophils, produce IFN-β in response to T. gondii infection.

Sat Nov 01 00:00:00 EDT 2014

Colitogenic effector T cells: roles of gut-homing integrin, gut antigen specificity and γδ T cells.

Immunology and cell biology

Do JS,Visperas A,Freeman ML,Iwakura Y,Oukka M,Min B

14-0112 was used in Flow cytometry/Cell sorting to demonstrate that T-cell colitogenicity is achieved through multiple processes, offering a therapeutic rationale by intervening these pathways.

Wed Jan 01 00:00:00 EST 2014

CX3CR1 delineates temporally and functionally distinct subsets of myeloid-derived suppressor cells in a mouse model of ovarian cancer.

Immunology and cell biology

Hart KM,Usherwood EJ,Berwin BL

14-0112 was used in Flow cytometry/Cell sorting to investigate a novel nongranulocytic CX3CR1-negative myeloid population.

Tue Jul 01 00:00:00 EDT 2014

Tracking the elusive fibrocyte: identification and characterization of collagen-producing hematopoietic lineage cells during murine wound healing.

Stem cells (Dayton, Ohio)

Suga H,Rennert RC,Rodrigues M,Sorkin M,Glotzbach JP,Januszyk M,Fujiwara T,Longaker MT,Gurtner GC

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu May 01 00:00:00 EDT 2014

Tracking the elusive fibrocyte: identification and characterization of collagen-producing hematopoietic lineage cells during murine wound healing.

Stem cells (Dayton, Ohio)

Suga H,Rennert RC,Rodrigues M,Sorkin M,Glotzbach JP,Januszyk M,Fujiwara T,Longaker MT,Gurtner GC

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu May 01 00:00:00 EDT 2014

TLR2-dependent activation of β-catenin pathway in dendritic cells induces regulatory responses and attenuates autoimmune inflammation.

Journal of immunology (Baltimore, Md. : 1950)

Manoharan I,Hong Y,Suryawanshi A,Angus-Hill ML,Sun Z,Mellor AL,Munn DH,Manicassamy S

14-0112 was used in Flow cytometry/Cell sorting to investigate how diametric signals from the pathogen recognition receptors TLR2 and dectin-1 are coordinated in dendritic cells to regulate or incite immunity.

Wed Oct 15 00:00:00 EDT 2014

The DC-HIL/syndecan-4 pathway regulates autoimmune responses through myeloid-derived suppressor cells.

Journal of immunology (Baltimore, Md. : 1950)

Chung JS,Tamura K,Akiyoshi H,Cruz PD,Ariizumi K

14-0112 was used in Flow cytometry/Cell sorting to investigate the mechanisms of regulation of autoimmune responses in experimental autoimmune encephalomyelitis.

Sat Mar 15 00:00:00 EDT 2014

Adoptively transferred immune T cells eradicate established tumors despite cancer-induced immune suppression.

Journal of immunology (Baltimore, Md. : 1950)

Arina A,Schreiber K,Binder DC,Karrison TG,Liu RB,Schreiber H

14-0112 was used in Flow cytometry/Cell sorting to study the effect of adoptively transferred immune T cells in the presence of MDSCs and TAMs on established tumours, showing that they are eradicated.

Sat Feb 01 00:00:00 EST 2014

Tryptophan catabolism restricts IFN-γ-expressing neutrophils and Clostridium difficile immunopathology.

Journal of immunology (Baltimore, Md. : 1950)

El-Zaatari M,Chang YM,Zhang M,Franz M,Shreiner A,McDermott AJ,van der Sluijs KF,Lutter R,Grasberger H,Kamada N,Young VB,Huffnagle GB,Kao JY

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Jul 15 00:00:00 EDT 2014

IRF4 in dendritic cells inhibits IL-12 production and controls Th1 immune responses against Leishmania major.

Journal of immunology (Baltimore, Md. : 1950)

Akbari M,Honma K,Kimura D,Miyakoda M,Kimura K,Matsuyama T,Yui K

14-0112 was used in Flow cytometry/Cell sorting to investigate the roles of the transcription factor IRF4 in dendritic cells and macrophages in vivo.

Sat Mar 01 00:00:00 EST 2014

B cell-specific loss of Lyn kinase leads to autoimmunity.

Journal of immunology (Baltimore, Md. : 1950)

Lamagna C,Hu Y,DeFranco AL,Lowell CA

14-0112-82 was used in Flow Cytometry to demonstrate that B cell-intrinsic Lyn-dependent signalling pathways regulate B cell homeostasis and activation.

Sat Feb 01 00:00:00 EST 2014

IL-21 receptor signalling partially mediates Th2-mediated allergic airway responses.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

Lajoie S,Lewkowich I,Herman NS,Sproles A,Pesce JT,Wynn TA,Grusby MJ,Hamid Q,Wills-Karp M

14-0112 was used in Flow cytometry/Cell sorting to suggest that IL-21 plays an important role in the allergic diathesis by enhancing Th2 cytokine production through multiple mechanisms.

Tue Jul 01 00:00:00 EDT 2014

A crucial role for β2 integrins in podosome formation, dynamics and Toll-like-receptor-signaled disassembly in dendritic cells.

Journal of cell science

Gawden-Bone C,West MA,Morrison VL,Edgar AJ,McMillan SJ,Dill BD,Trost M,Prescott A,Fagerholm SC,Watts C

14-0112 was used in Flow cytometry/Cell sorting to assess the contribution of integrins to the function and maintenance of podosomes.

Wed Oct 01 00:00:00 EDT 2014

Natural history of tumor growth and immune modulation in common spontaneous murine mammary tumor models.

Breast cancer research and treatment

Gad E,Rastetter L,Slota M,Koehnlein M,Treuting PM,Dang Y,Stanton S,Disis ML

14-0112 was used in Flow cytometry/Cell sorting to evaluate the relationship between growth rates of tumours in common spontaneous mammary tumor models and immune biomarkers evaluated in the tumour and blood.

Mon Dec 01 00:00:00 EST 2014

Memory B cells form in aged mice despite impaired affinity maturation and germinal center kinetics.

Experimental gerontology

Goenka R,Scholz JL,Naradikian MS,Cancro MP

14-0112 was used in Flow cytometry/Cell sorting to study how age influences the overall germinal centre reaction during a primary immune response to a thymus-dependent antigen.

Sun Jun 01 00:00:00 EDT 2014

Treatment of experimental stroke with IL-10-producing B-cells reduces infarct size and peripheral and CNS inflammation in wild-type B-cell-sufficient mice.

Metabolic brain disease

Bodhankar S,Chen Y,Vandenbark AA,Murphy SJ,Offner H

14-0112 was used in Flow cytometry/Cell sorting to investigate the beneficial immunoregulatory effects of IL-10-producing B-cell stroke treatment in mice.

Sat Mar 01 00:00:00 EST 2014

Deficiency of lymph node-resident dendritic cells (DCs) and dysregulation of DC chemoattractants in a malnourished mouse model of Leishmania donovani infection.

Infection and immunity

Ibrahim MK,Barnes JL,Osorio EY,Anstead GM,Jimenez F,Osterholzer JJ,Travi BL,Ahuja SS,White AC,Melby PC

14-0112 was used in Flow cytometry/Cell sorting to study populations of resident dendritic cells and migratory dermal dendritic cells in the skin-draining lymph nodes of L. donovani-infected malnourished mice.

Fri Aug 01 00:00:00 EDT 2014

Increased expression of stress inducible protein 1 in glioma-associated microglia/macrophages.

Journal of neuroimmunology

Carvalho da Fonseca AC,Wang H,Fan H,Chen X,Zhang I,Zhang L,Lima FR,Badie B

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Mon Sep 15 00:00:00 EDT 2014

Systemic sensitization with the protein allergen ovalbumin augments local sensitization in atopic dermatitis.

Journal of inflammation research

Yoo J,Manicone AM,McGuire JK,Wang Y,Parks WC

14-0112 was used in Immunofluorescence to reveal a mouse model of atopic dermatitis that reveals novel insights into the pathogenesis of this complex disease.

Thu Mar 27 00:00:00 EDT 2014

Protective immunity against lethal F. tularensis holarctica LVS provided by vaccination with selected novel CD8+ T cell epitopes.

PloS one

Rotem S,Cohen O,Bar-Haim E,Bar-On L,Ehrlich S,Shafferman A

14-0112 was used in Flow cytometry/Cell sorting to demonstrate a novel method for bacterial clearance involving the induction of an immune response to specific pathogenic epitopes.

Wed Sep 10 00:00:00 EDT 2014

Identification of Toll-like receptor 9 as parapoxvirus ovis-sensing receptor in plasmacytoid dendritic cells.

PloS one

von Buttlar H,Siegemund S,Büttner M,Alber G

14-0112 was used in an ELISA assay to identify endosomal TLR9 as PPVO-sensing receptor in pDC.

Tue Nov 10 00:00:00 EST 2015

Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression.

Nature communications

Chen L,Gibbons DL,Goswami S,Cortez MA,Ahn YH,Byers LA,Zhang X,Yi X,Dwyer D,Lin W,Diao L,Wang J,Roybal J,Patel M,Ungewiss C,Peng D,Antonia S,Mediavilla-Varela M,Robertson G,Suraokar M,Welsh JW,Erez B,Wistuba II,Chen L,Peng D,Wang S,Ullrich SE,Heymach JV,Kurie JM,Qin FX

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Oct 28 00:00:00 EDT 2014

Amniotic fluid stem cells prevent follicle atresia and rescue fertility of mice with premature ovarian failure induced by chemotherapy.

PloS one

Xiao GY,Liu IH,Cheng CC,Chang CC,Lee YH,Cheng WT,Wu SC

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu May 28 00:00:00 EDT 2015

Tissue-resident natural killer (NK) cells are cell lineages distinct from thymic and conventional splenic NK cells.

eLife

Sojka DK,Plougastel-Douglas B,Yang L,Pak-Wittel MA,Artyomov MN,Ivanova Y,Zhong C,Chase JM,Rothman PB,Yu J,Riley JK,Zhu J,Tian Z,Yokoyama WM

14-0112 was used in Flow cytometry/Cell sorting to investigate whether tissue-resident and cells resembling conventional splenic natural killer cells natural killer cells are derived from the same lineage, showing that there are at least four distinct lineages.

Wed Jan 01 00:00:00 EST 2014

A flagellin-derived toll-like receptor 5 agonist stimulates cytotoxic lymphocyte-mediated tumor immunity.

PloS one

Leigh ND,Bian G,Ding X,Liu H,Aygun-Sunar S,Burdelya LG,Gudkov AV,Cao X

14-0112 was used in Flow cytometry/Cell sorting to assess the immunogenic capabilities of CBLB502, a toll-like receptor 5 agonist.

Wed Sep 17 00:00:00 EDT 2014

Epigenetic plasticity of Cd8a locus during CD8(+) T-cell development and effector differentiation and reprogramming.

Nature communications

Harland KL,Day EB,Apte SH,Russ BE,Doherty PC,Turner SJ,Kelso A

14-0112 was used in Flow cytometry/Cell sorting to study whether epigenetic modifications affecting T-cells persist following adoptive transfer of the cells.

Fri Mar 28 00:00:00 EDT 2014

Anti-tumor innate immunity activated by intermittent metronomic cyclophosphamide treatment of 9L brain tumor xenografts is preserved by anti-angiogenic drugs that spare VEGF receptor 2.

Molecular cancer

Doloff JC,Chen CS,Waxman DJ

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu Jun 26 00:00:00 EDT 2014

Nfatc2 and Tob1 have non-overlapping function in T cell negative regulation and tumorigenesis.

PloS one

May SL,Zhou Q,Lewellen M,Carter CM,Coffey D,Highfill SL,Bucher CM,Matise I,Morse HC,O'Sullivan MG,Schutten M,Johnson C,Bellgrau D,Blazar BR,Modiano JF

14-0112 was used in Flow cytometry/Cell sorting to study how Nfatc2 and Tob1 are non-redundant regulators of lymphocyte homeostasis.

Mon Oct 19 00:00:00 EDT 2015

Activated macrophage survival is coordinated by TAK1 binding proteins.

PloS one

Mihaly SR,Morioka S,Ninomiya-Tsuji J,Takaesu G

14-0112 was used in Flow cytometry/Cell sorting to investigate the role of TAB1 and TAB2 in macrophage survival.

Fri Jan 16 00:00:00 EST 2015

Myeloid lineage-specific deletion of antioxidant system enhances tumor metastasis.

Cancer prevention research (Philadelphia, Pa.)

Hiramoto K,Satoh H,Suzuki T,Moriguchi T,Pi J,Shimosegawa T,Yamamoto M

14-0112 was used in Flow cytometry/Cell sorting to investigate whether cellular antioxidant defence systems in myeloid lineage cells plays indispensable roles for metastatic cancer progression.

Fri Aug 01 00:00:00 EDT 2014

Leukocyte population dynamics and detection of IL-9 as a major cytokine at the mouse fetal-maternal interface.

PloS one

Habbeddine M,Verbeke P,Karaz S,Bobé P,Kanellopoulos-Langevin C

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Wed Jun 10 00:00:00 EDT 2015

P2X7 receptor modulates inflammatory and functional pulmonary changes induced by silica.

PloS one

Monção-Ribeiro LC,Faffe DS,Santana PT,Vieira FS,da Graça CL,Marques-da-Silva C,Machado MN,Caruso-Neves C,Zin WA,Borojevic R,Takiya CM,Coutinho-Silva R

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu Sep 17 00:00:00 EDT 2015

The nucleotide-binding leucine-rich repeat (NLR) family member NLRX1 mediates protection against experimental autoimmune encephalomyelitis and represses macrophage/microglia-induced inflammation.

The Journal of biological chemistry

Eitas TK,Chou WC,Wen H,Gris D,Robbins GR,Brickey J,Oyama Y,Ting JP

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Fri Feb 14 00:00:00 EST 2014

Intravenous immunoglobulin (IVIg) provides protection against endothelial cell dysfunction and death in ischemic stroke.

Experimental & translational stroke medicine

Widiapradja A,Santro T,Basta M,Sobey CG,Manzanero S,Arumugam TV

14-0112 was used in Flow cytometry/Cell sorting to study how intravenous immunoglobulin protects endothelial cells from ischaemic insult, supporting its use as a pharmacological intervention for stroke therapy.

Thu Jul 03 00:00:00 EDT 2014

RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3.

Nature

Lukens JR,Vogel P,Johnson GR,Kelliher MA,Iwakura Y,Lamkanfi M,Kanneganti TD

14-0112 was used in Flow cytometry/Cell sorting to investigate how mutations in SHP-1 causes inflammatory disease, showing that RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3.

Thu Jun 13 00:00:00 EDT 2013

A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing.

Nature

Florian MC,Nattamai KJ,Dörr K,Marka G,Uberle B,Vas V,Eckl C,Andrä I,Schiemann M,Oostendorp RA,Scharffetter-Kochanek K,Kestler HA,Zheng Y,Geiger H

14-0112 was used in Immunocytochemistry to evaluate the role of Wnt signalling in the ageing of haematopoietic stem cells in mice.

Thu Nov 21 00:00:00 EST 2013

T cell factor 1 is required for group 2 innate lymphoid cell generation.

Immunity

Yang Q,Monticelli LA,Saenz SA,Chi AW,Sonnenberg GF,Tang J,De Obaldia ME,Bailis W,Bryson JL,Toscano K,Huang J,Haczku A,Pear WS,Artis D,Bhandoola A

14-0112 was used in Flow cytometry/Cell sorting to study group 2 innate lymphoid cell development.

Thu Apr 18 00:00:00 EDT 2013

Anatomically restricted synergistic antiviral activities of innate and adaptive immune cells in the skin.

Cell host & microbe

Hickman HD,Reynoso GV,Ngudiankama BF,Rubin EJ,Magadán JG,Cush SS,Gibbs J,Molon B,Bronte V,Bennink JR,Yewdell JW

14-0112 was used in Flow cytometry/Cell sorting to explore the spatiotemporal organization between antiviral immune cells and vaccinia virus-infected murine cells.

Wed Feb 13 00:00:00 EST 2013

Natural killer cells are required for extramedullary hematopoiesis following murine cytomegalovirus infection.

Cell host & microbe

Jordan S,Ruzsics Z,Mitrović M,Baranek T,Arapović J,Krmpotić A,Vivier E,Dalod M,Jonjić S,Dölken L,Koszinowski UH

14-0112 was used in Flow cytometry/Cell sorting to investigate the underlying mechanisms of extramedullary hematopoiesis.

Wed May 15 00:00:00 EDT 2013

Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells.

Nature immunology

Cohen NR,Brennan PJ,Shay T,Watts GF,Brigl M,Kang J,Brenner MB

14-0112 was used in Flow cytometry/Cell sorting to profile gene expression in invariant natural killer T cells during ontogeny and in peripheral subsets.

Tue Jan 01 00:00:00 EST 2013

Nrf2 regulates haematopoietic stem cell function.

Nature cell biology

Tsai JJ,Dudakov JA,Takahashi K,Shieh JH,Velardi E,Holland AM,Singer NV,West ML,Smith OM,Young LF,Shono Y,Ghosh A,Hanash AM,Tran HT,Moore MA,van den Brink MR

14-0112 was used in Flow cytometry/Cell sorting to investigate the link between Nrf2 and CXCR4, thought to partially contribute to the maintenance of haematopoietic stem cell function.

Fri Mar 01 00:00:00 EST 2013

miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis.

Nature cell biology

Zhang Y,Yang P,Sun T,Li D,Xu X,Rui Y,Li C,Chong M,Ibrahim T,Mercatali L,Amadori D,Lu X,Xie D,Li QJ,Wang XF

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Fri Mar 01 00:00:00 EST 2013

COP1 targets C/EBPα for degradation and induces acute myeloid leukemia via Trib1.

Blood

Yoshida A,Kato JY,Nakamae I,Yoneda-Kato N

14-0112 was used in Flow cytometry/Cell sorting to investigate the role of COP1 in tumourigenesis.

Thu Sep 05 00:00:00 EDT 2013

Inflammatory neovascularization during graft-versus-host disease is regulated by αv integrin and miR-100.

Blood

Leonhardt F,Grundmann S,Behe M,Bluhm F,Dumont RA,Braun F,Fani M,Riesner K,Prinz G,Hechinger AK,Gerlach UV,Dierbach H,Penack O,Schmitt-Gräff A,Finke J,Weber WA,Zeiser R

14-0112-82 was used in Flow Cytometry to identify negative regulation of GvHD-related neovascularization by miR-100.

Thu Apr 25 00:00:00 EDT 2013

HIF prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress.

Blood

Singh RP,Franke K,Kalucka J,Mamlouk S,Muschter A,Gembarska A,Grinenko T,Willam C,Naumann R,Anastassiadis K,Stewart AF,Bornstein S,Chavakis T,Breier G,Waskow C,Wielockx B

14-0112 was used in Flow cytometry/Cell sorting to study the role of PHD2 in HSC compartment maintenance.

Thu Jun 27 00:00:00 EDT 2013

Immune response to RB1-regulated senescence limits radiation-induced osteosarcoma formation.

The Journal of clinical investigation

Kansara M,Leong HS,Lin DM,Popkiss S,Pang P,Garsed DW,Walkley CR,Cullinane C,Ellul J,Haynes NM,Hicks R,Kuijjer ML,Cleton-Jansen AM,Hinds PW,Smyth MJ,Thomas DM

14-0112 was used in Flow cytometry/Cell sorting to indicate that overcoming the immune response to senescence is a rate-limiting step in the formation of IR-induced osteosarcoma.

Sun Dec 01 00:00:00 EST 2013

MIP-1α/CCL3-mediated maintenance of leukemia-initiating cells in the initiation process of chronic myeloid leukemia.

The Journal of experimental medicine

Baba T,Naka K,Morishita S,Komatsu N,Hirao A,Mukaida N

14-0112 was used in Flow cytometry/Cell sorting to investigate the interaction between leukaemia-initiating cells and normal hematopoietic cells at the early phase of chronic myeloid leukaemia, showing MIP-1α/CCL3-mediated maintenance of initiating cells.

Mon Nov 18 00:00:00 EST 2013

Gata2 cis-element is required for hematopoietic stem cell generation in the mammalian embryo.

The Journal of experimental medicine

Gao X,Johnson KD,Chang YI,Boyer ME,Dewey CN,Zhang J,Bresnick EH

14-0112 was used in Flow cytometry/Cell sorting to investigate the role of Gata2 cis-element in generation of hematopoietic stem cells.

Mon Dec 16 00:00:00 EST 2013

HDL and Glut1 inhibition reverse a hypermetabolic state in mouse models of myeloproliferative disorders.

The Journal of experimental medicine

Gautier EL,Westerterp M,Bhagwat N,Cremers S,Shih A,Abdel-Wahab O,Lütjohann D,Randolph GJ,Levine RL,Tall AR,Yvan-Charvet L

14-0112 was used in Flow cytometry/Cell sorting to investigate the underlying mechanisms leading to high metabolic rate in myeloproliferative disorders, showing that HDL and Glut1 inhibition reverse hypermetabolic state.

Mon Feb 11 00:00:00 EST 2013

S100B promotes glioma growth through chemoattraction of myeloid-derived macrophages.

Clinical cancer research : an official journal of the American Association for Cancer Research

Wang H,Zhang L,Zhang IY,Chen X,Da Fonseca A,Wu S,Ren H,Badie S,Sadeghi S,Ouyang M,Warden CD,Badie B

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Mon Jul 15 00:00:00 EDT 2013

A network of interactions enables CCM3 and STK24 to coordinate UNC13D-driven vesicle exocytosis in neutrophils.

Developmental cell

Zhang Y,Tang W,Zhang H,Niu X,Xu Y,Zhang J,Gao K,Pan W,Boggon TJ,Toomre D,Min W,Wu D

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Mon Oct 28 00:00:00 EDT 2013

Avirulent Toxoplasma gondii generates therapeutic antitumor immunity by reversing immunosuppression in the ovarian cancer microenvironment.

Cancer research

Baird JR,Fox BA,Sanders KL,Lizotte PH,Cubillos-Ruiz JR,Scarlett UK,Rutkowski MR,Conejo-Garcia JR,Fiering S,Bzik DJ

14-0112 was used in Flow cytometry/Cell sorting to establish that cps preferentially invades tumour-associated antigen-presenting cells and restores their ability to trigger potent anti-tumour CD8(+) T-cell responses.

Mon Jul 01 00:00:00 EDT 2013

Motile invaded neutrophils in the small intestine of Toxoplasma gondii-infected mice reveal a potential mechanism for parasite spread.

Proceedings of the National Academy of Sciences of the United States of America

Coombes JL,Charsar BA,Han SJ,Halkias J,Chan SW,Koshy AA,Striepen B,Robey EA

14-0112 was used in Flow cytometry/Cell sorting to explore the parasite-host interaction between Toxoplasma gondii and intestinal immune cells.

Tue May 21 00:00:00 EDT 2013

Interleukin-6-signal transducer and activator of transcription-3 signaling mediates aortic dissections induced by angiotensin II via the T-helper lymphocyte 17-interleukin 17 axis in C57BL/6 mice.

Arteriosclerosis, thrombosis, and vascular biology

Ju X,Ijaz T,Sun H,Ray S,Lejeune W,Lee C,Recinos A,Guo DC,Milewicz DM,Tilton RG,Brasier AR

14-0112 was used in Flow cytometry/Cell sorting to suggest that the Th17-IL-17 axis is an important effector arm of Ang II-mediated vascular inflammation.

Mon Jul 01 00:00:00 EDT 2013

Activator protein-2α mediates carbon monoxide-induced stromal cell-derived factor-1α expression and vascularization in ischemic heart.

Arteriosclerosis, thrombosis, and vascular biology

Lin HH,Chen YH,Chiang MT,Huang PL,Chau LY

14-0112 was used in Immunohistochemistry to demonstrate that AKT-dependent upregulation of AP-2α is essential for CO-induced SDF-1α expression and myocardial repair after ischemic injury.

Mon Apr 01 00:00:00 EDT 2013

Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation.

eLife

Kerenyi MA,Shao Z,Hsu YJ,Guo G,Luc S,O'Brien K,Fujiwara Y,Peng C,Nguyen M,Orkin SH

14-0112 was used in Flow cytometry/Cell sorting to study how Lsd1-mediated concurrent repression of enhancer and promoter activity of stem and progenitor cell genes is a pivotal epigenetic mechanism required for proper hematopoietic maturation.

Tue Jun 18 00:00:00 EDT 2013

MYBL2 is a sub-haploinsufficient tumor suppressor gene in myeloid malignancy.

eLife

Heinrichs S,Conover LF,Bueso-Ramos CE,Kilpivaara O,Stevenson K,Neuberg D,Loh ML,Wu WS,Rodig SJ,Garcia-Manero G,Kantarjian HM,Look AT

14-0112 was used in Flow cytometry/Cell sorting to demonstrate that low MYBL2 activity is the underlying cause of the expansion of haematopoietic progenitors in a large fraction of myeloid malignancies.

Tue Jul 16 00:00:00 EDT 2013

Klf10 inhibits IL-12p40 production in macrophage colony-stimulating factor-induced mouse bone marrow-derived macrophages.

European journal of immunology

Zhang W,Wang X,Xia X,Liu X,Suo S,Guo J,Li M,Cao W,Cai Z,Hui Z,Subramaniam M,Spelsberg TC,Wang J,Wang L

14-0112 was used in Flow cytometry/Cell sorting to identify Klf10 as a transcription factor that regulates the expression of IL-12p40 in bone marrow-derived macrophages.

Tue Jan 01 00:00:00 EST 2013

Microvascular COX-2/mPGES-1/EP-4 axis in human abdominal aortic aneurysm.

Journal of lipid research

Camacho M,Dilmé J,Solà-Villà D,Rodríguez C,Bellmunt S,Siguero L,Alcolea S,Romero JM,Escudero JR,Martínez-González J,Vila L

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunohistochemistry

Sun Dec 01 00:00:00 EST 2013

Transgenic CCL2 expression in the central nervous system results in a dysregulated immune response and enhanced lethality after coronavirus infection.

Journal of virology

Trujillo JA,Fleming EL,Perlman S

14-0112 was used in Flow cytometry/Cell sorting to examine the role of CCL2 during virus infection, showing that CCL2 expression in the CNS results in a dysregulated immune response after coronavirus infection.

Fri Mar 01 00:00:00 EST 2013

Alcam regulates long-term hematopoietic stem cell engraftment and self-renewal.

Stem cells (Dayton, Ohio)

Jeannet R,Cai Q,Liu H,Vu H,Kuo YH

14-0112 was used in Flow cytometry/Cell sorting to investigate the role of activated leukocyte cell adhesion molecule in hematopoietic stem cell differentiation and self-renewal using an Alcam-null mouse model.

Fri Mar 01 00:00:00 EST 2013

ICAM-1-dependent homotypic aggregates regulate CD8 T cell effector function and differentiation during T cell activation.

Journal of immunology (Baltimore, Md. : 1950)

Zumwalde NA,Domae E,Mescher MF,Shimizu Y

14-0112 was used in Flow cytometry/Cell sorting to demonstrate that during CD8 T cell activation, the T cell clustering mechanism allows for continued proliferation of T cells, and regulates CD8 T cell effector function and differentiation.

Tue Oct 01 00:00:00 EDT 2013

Cell-specific TLR9 trafficking in primary APCs of transgenic TLR9-GFP mice.

Journal of immunology (Baltimore, Md. : 1950)

Avalos AM,Kirak O,Oelkers JM,Pils MC,Kim YM,Ottinger M,Jaenisch R,Ploegh HL,Brinkmann MM

14-0112 was used in Flow cytometry/Cell sorting to examine the intracellular behavior of TLR9 in primary APCs.

Tue Jan 15 00:00:00 EST 2013

The influence of T cell Ig mucin-3 signaling on central nervous system autoimmune disease is determined by the effector function of the pathogenic T cells.

Journal of immunology (Baltimore, Md. : 1950)

Lee SY,Goverman JM

14-0112 was used in Flow cytometry/Cell sorting to analyse the role of Tim-3 signalling within various innate immune cells on the development of experimental autoimmune encephalomyelitis.

Wed May 15 00:00:00 EDT 2013

FOXM1 promotes allergen-induced goblet cell metaplasia and pulmonary inflammation.

Molecular and cellular biology

Ren X,Shah TA,Ustiyan V,Zhang Y,Shinn J,Chen G,Whitsett JA,Kalin TV,Kalinichenko VV

14-0112 was used in Flow cytometry/Cell sorting to investigate the role of transcriptional control of goblet cell differentiation and mucus hyperproduction, showing that FOXM1 promotes allergen-induced metaplasia and pulmonary inflammation.

Tue Jan 01 00:00:00 EST 2013

TiF1-gamma plays an essential role in murine hematopoiesis and regulates transcriptional elongation of erythroid genes.

Developmental biology

Bai X,Trowbridge JJ,Riley E,Lee JA,DiBiase A,Kaartinen VM,Orkin SH,Zon LI

14-0112 was used in Flow cytometry/Cell sorting to study the role of TIF1γ in murine erythropoiesis and to assess its function in other blood lineages.

Tue Jan 15 00:00:00 EST 2013

Migration of bone marrow-derived cells into the central nervous system in models of neurodegeneration.

The Journal of comparative neurology

Lampron A,Pimentel-Coelho PM,Rivest S

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Sun Dec 01 00:00:00 EST 2013

The cardioprotective protein apolipoprotein A1 promotes potent anti-tumorigenic effects.

The Journal of biological chemistry

Zamanian-Daryoush M,Lindner D,Tallant TC,Wang Z,Buffa J,Klipfell E,Parker Y,Hatala D,Parsons-Wingerter P,Rayman P,Yusufishaq MSS,Fisher EA,Smith JD,Finke J,DiDonato JA,Hazen SL

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Fri Jul 19 00:00:00 EDT 2013

The cardioprotective protein apolipoprotein A1 promotes potent anti-tumorigenic effects.

The Journal of biological chemistry

Zamanian-Daryoush M,Lindner D,Tallant TC,Wang Z,Buffa J,Klipfell E,Parker Y,Hatala D,Parsons-Wingerter P,Rayman P,Yusufishaq MSS,Fisher EA,Smith JD,Finke J,DiDonato JA,Hazen SL

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Fri Jul 19 00:00:00 EDT 2013

Gr1(int)CD11b+ myeloid-derived suppressor cells in Mycobacterium tuberculosis infection.

PloS one

Obregón-Henao A,Henao-Tamayo M,Orme IM,Ordway DJ

14-0112 was used in Flow cytometry/Cell sorting to compare the bacterial burden, lung pathology and Gr1(int)CD11b(+) myeloid-derived suppressor cell immune responses in M. tuberculosis infected mice.

Fri Jun 20 00:00:00 EDT 2014

Intravital immunofluorescence for visualizing the microcirculatory and immune microenvironments in the mouse ear dermis.

PloS one

Kilarski WW,Güç E,Teo JC,Oliver SR,Lund AW,Swartz MA

14-0112-82 was used in Immunocytochemistry to develop an antibody-based method for intravital imaging of cell interactions of the living dermis while simultaneously assessing capillary permeability and lymphatic drainage function.

Fri Sep 27 00:00:00 EDT 2013

Cross-activating invariant NKT cells and kupffer cells suppress cholestatic liver injury in a mouse model of biliary obstruction.

PloS one

Duwaerts CC,Sun EP,Cheng CW,van Rooijen N,Gregory SH

14-0112 was used in Flow cytometry/Cell sorting to investigate whether iNKT and Kupffer cell suppression of neutrophil-dependent liver injury is interdependent, showing that cross-activation allows suppression of injury.

Fri Jul 11 00:00:00 EDT 2014

PD-L1 enhances CNS inflammation and infarct volume following experimental stroke in mice in opposition to PD-1.

Journal of neuroinflammation

Bodhankar S,Chen Y,Vandenbark AA,Murphy SJ,Offner H

14-0112 was used in Flow cytometry/Cell sorting to suggest that agents (for example antibodies) that can target and neutralise PD-L1/2 may have therapeutic potential for treatment of human stroke.

Mon Sep 09 00:00:00 EDT 2013

Bile acid receptor activation modulates hepatic monocyte activity and improves nonalcoholic fatty liver disease.

The Journal of biological chemistry

McMahan RH,Wang XX,Cheng LL,Krisko T,Smith M,El Kasmi K,Pruzanski M,Adorini L,Golden-Mason L,Levi M,Rosen HR

14-0112 was used in Flow cytometry/Cell sorting to demonstrate that FXR/TGR5 activation coordinates the immune phenotype of monocytes and macrophages.

Fri Apr 26 00:00:00 EDT 2013

Identification of the low density lipoprotein (LDL) receptor-related protein-1 interactome in central nervous system myelin suggests a role in the clearance of necrotic cell debris.

The Journal of biological chemistry

Fernandez-Castaneda A,Arandjelovic S,Stiles TL,Schlobach RK,Mowen KA,Gonias SL,Gaultier A

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Fri Feb 15 00:00:00 EST 2013

In vivo knockdown of TAK1 accelerates bone marrow proliferation/differentiation and induces systemic inflammation.

PloS one

Vink PM,Smout WM,Driessen-Engels LJ,de Bruin AM,Delsing D,Krajnc-Franken MA,Jansen AJ,Rovers EF,van Puijenbroek AA,Kaptein A,Nolte MA,Garritsen A,van Eenennaam H

14-0112 was used in Flow cytometry/Cell sorting to study the function of TAK1 protein in the adult immune system.

Fri Sep 06 00:00:00 EDT 2013

Novel n-3 immunoresolvents: structures and actions.

Scientific reports

Dalli J,Colas RA,Serhan CN

14-0112 was used in Flow cytometry/Cell sorting to investigate the process of conversion of n-3 DPA to novel immunoresolvents for the resolution of inflammation.

Thu Oct 24 00:00:00 EDT 2013

Prostaglandin E2 suppresses antifungal immunity by inhibiting interferon regulatory factor 4 function and interleukin-17 expression in T cells.

Immunity

Valdez PA,Vithayathil PJ,Janelsins BM,Shaffer AL,Williamson PR,Datta SK

14-0112 was used in Flow cytometry/Cell sorting to study the effect of prostaglandin E2 on the function of Th17 cells during differentiation.

Fri Apr 20 00:00:00 EDT 2012

Autophagy links inflammasomes to atherosclerotic progression.

Cell metabolism

Razani B,Feng C,Coleman T,Emanuel R,Wen H,Hwang S,Ting JP,Virgin HW,Kastan MB,Semenkovich CF

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunofluorescence

Wed Apr 04 00:00:00 EDT 2012

Molecular definition of the identity and activation of natural killer cells.

Nature immunology

Bezman NA,Kim CC,Sun JC,Min-Oo G,Hendricks DW,Kamimura Y,Best JA,Goldrath AW,Lanier LL

14-0112 was used in Flow cytometry/Cell sorting to systematically define the transcriptome of mouse natural killer cells in several contexts.

Mon Oct 01 00:00:00 EDT 2012

Endothelial cells provide an instructive niche for the differentiation and functional polarization of M2-like macrophages.

Blood

He H,Xu J,Warren CM,Duan D,Li X,Wu L,Iruela-Arispe ML

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu Oct 11 00:00:00 EDT 2012

Fibroblast growth factor-7 partially reverses murine thymocyte progenitor aging by repression of Ink4a.

Blood

Berent-Maoz B,Montecino-Rodriguez E,Signer RA,Dorshkind K

14-0112 was used in Flow cytometry/Cell sorting to define a genetic basis for thymocyte progenitor aging.

Thu Jun 14 00:00:00 EDT 2012

Cis-element mutated in GATA2-dependent immunodeficiency governs hematopoiesis and vascular integrity.

The Journal of clinical investigation

Johnson KD,Hsu AP,Ryu MJ,Wang J,Gao X,Boyer ME,Liu Y,Lee Y,Calvo KR,Keles S,Zhang J,Holland SM,Bresnick EH

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Mon Oct 01 00:00:00 EDT 2012

Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice.

The Journal of experimental medicine

Billiard F,Lobry C,Darrasse-Jèze G,Waite J,Liu X,Mouquet H,DaNave A,Tait M,Idoyaga J,Leboeuf M,Kyratsous CA,Burton J,Kalter J,Klinakis A,Zhang W,Thurston G,Merad M,Steinman RM,Murphy AJ,Yancopoulos GD,Aifantis I,Skokos D

14-0112 was used in Flow cytometry/Cell sorting to investigate how Dll4-Notch signaling affects pro-T cell fate and thymic DC development, showing that it is a novel Flt3-independent pathway for DC development and autoimmunity.

Mon May 07 00:00:00 EDT 2012

Identification of a genetic locus controlling bacteria-driven colitis and associated cancer through effects on innate inflammation.

The Journal of experimental medicine

Boulard O,Kirchberger S,Royston DJ,Maloy KJ,Powrie FM

14-0112 was used in Flow cytometry/Cell sorting to investigate the genetic factors influencing the progression from Helicobacter hepaticus-driven colitis to tumorigenesis in a mouse model.

Mon Jul 02 00:00:00 EDT 2012

Lung B cells promote early pathogen dissemination and hasten death from inhalation anthrax.

Mucosal immunology

Rayamajhi M,Delgado C,Condon TV,Riches DW,Lenz LL

14-0112 was used in Flow cytometry/Cell sorting to investigate mechanisms of Bacillus anthracis spore traffic from the lungs to the lung-draining lymph nodes in a mouse model of inhalation anthrax.

Sun Jul 01 00:00:00 EDT 2012

Plasmacytoid dendritic cells sequester high prion titres at early stages of prion infection.

PLoS pathogens

Castro-Seoane R,Hummerich H,Sweeting T,Tattum MH,Linehan JM,Fernandez de Marco M,Brandner S,Collinge J,Klöhn PC

14-0112 was used in Flow cytometry/Cell sorting to study the kinetics of prion accumulation in various splenic cell types at early stages of prion infection in mice.

Wed Feb 01 00:00:00 EST 2012

Neuroprotective effects of toll-like receptor 4 antagonism in spinal cord cultures and in a mouse model of motor neuron degeneration.

Molecular medicine (Cambridge, Mass.)

De Paola M,Mariani A,Bigini P,Peviani M,Ferrara G,Molteni M,Gemma S,Veglianese P,Castellaneta V,Boldrin V,Rossetti C,Chiabrando C,Forloni G,Mennini T,Fanelli R

14-0112 was used in Immunocytochemistry to investigate the role of TLR4 in in vitro and in vivo settings of motor neuron degeneration.

Fri Sep 07 00:00:00 EDT 2012

ADAM17 activation in circulating neutrophils following bacterial challenge impairs their recruitment.

Journal of leukocyte biology

Long C,Hosseinkhani MR,Wang Y,Sriramarao P,Walcheck B

14-0112 was used in Flow cytometry/Cell sorting to study how impaired L-selectin shedding is a key mechanism underlying early neutrophil recruitment in conditional ADAM17 knockout mice during bacterial infection.

Sat Sep 01 00:00:00 EDT 2012

Myeloid-derived suppressor cells from tumor-bearing mice impair TGF-β-induced differentiation of CD4+CD25+FoxP3+ Tregs from CD4+CD25-FoxP3- T cells.

Journal of leukocyte biology

Centuori SM,Trad M,LaCasse CJ,Alizadeh D,Larmonier CB,Hanke NT,Kartchner J,Janikashvili N,Bonnotte B,Larmonier N,Katsanis E

14-0112 was used in Immunohistochemistry to indicate that gr-MDSCs from TB hosts have the unanticipated ability to restrict immunosuppressive Tregs.

Thu Nov 01 00:00:00 EDT 2012

Kupffer cells express a unique combination of phenotypic and functional characteristics compared with splenic and peritoneal macrophages.

Journal of leukocyte biology

Movita D,Kreefft K,Biesta P,van Oudenaren A,Leenen PJ,Janssen HL,Boonstra A

14-0112 was used in Flow cytometry/Cell sorting to observe that freshly isolated Kupffer cells are endocytic and show a relatively high basal ROS content.

Mon Oct 01 00:00:00 EDT 2012

A TLR5 agonist enhances CD8(+) T cell-mediated graft-versus-tumor effect without exacerbating graft-versus-host disease.

Journal of immunology (Baltimore, Md. : 1950)

Ding X,Bian G,Leigh ND,Qiu J,McCarthy PL,Liu H,Aygun-Sunar S,Burdelya LG,Gudkov AV,Cao X

14-0112 was used in Flow cytometry/Cell sorting to investigate the effect of CBLB502 on graft-versus-tumour activity.

Thu Nov 15 00:00:00 EST 2012

Cutting edge: LPS-induced emergency myelopoiesis depends on TLR4-expressing nonhematopoietic cells.

Journal of immunology (Baltimore, Md. : 1950)

Boettcher S,Ziegler P,Schmid MA,Takizawa H,van Rooijen N,Kopf M,Heikenwalder M,Manz MG

14-0112 was used in Flow cytometry/Cell sorting to demonstrate that TLR4-expressing nonhematopoietic cells are indispensable for LPS-induced, G-CSF-mediated myelopoietic responses.

Fri Jun 15 00:00:00 EDT 2012

The bone marrow functions as the central site of proliferation for long-lived NK cells.

Journal of immunology (Baltimore, Md. : 1950)

van Helden MJ,de Graaf N,Boog CJ,Topham DJ,Zaiss DM,Sijts AJ

14-0112 was used in Flow cytometry/Cell sorting to investigate the dynamics of natural killer cell responses after intranasal respiratory virus infection in mice.

Sat Sep 01 00:00:00 EDT 2012

Glucocorticoids relieve collectin-driven suppression of apoptotic cell uptake in murine alveolar macrophages through downregulation of SIRPα.

Journal of immunology (Baltimore, Md. : 1950)

McCubbrey AL,Sonstein J,Ames TM,Freeman CM,Curtis JL

14-0112 was used in Flow cytometry/Cell sorting to determine whether glucocorticoid treatment acts to increase apoptotic cell uptake by differentiated tissue macrophages.

Sun Jul 01 00:00:00 EDT 2012

The endothelial antigen ESAM monitors hematopoietic stem cell status between quiescence and self-renewal.

Journal of immunology (Baltimore, Md. : 1950)

Sudo T,Yokota T,Oritani K,Satoh Y,Sugiyama T,Ishida T,Shibayama H,Ezoe S,Fujita N,Tanaka H,Maeda T,Nagasawa T,Kanakura Y

14-0112 was used in Flow cytometry/Cell sorting to demonstrate that the intensity of ESAM expression is useful to trace activated HSCs.

Sun Jul 01 00:00:00 EDT 2012

Exposure to nicotine adversely affects the dendritic cell system and compromises host response to vaccination.

Journal of immunology (Baltimore, Md. : 1950)

Nouri-Shirazi M,Guinet E

14-0112 was used in Flow cytometry/Cell sorting to investigate the causal relationship between nicotine-induced dendritic cell alterations and host response to vaccines.

Thu Mar 01 00:00:00 EST 2012

Semaphorin 7a links nerve regeneration and inflammation in the cornea.

Investigative ophthalmology & visual science

Namavari A,Chaudhary S,Ozturk O,Chang JH,Yco L,Sonawane S,Katam N,Khanolkar V,Hallak J,Sarkar J,Jain S

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunofluorescence

Mon Jul 09 00:00:00 EDT 2012

EP2 and EP4 receptors on muscularis resident macrophages mediate LPS-induced intestinal dysmotility via iNOS upregulation through cAMP/ERK signals.

American journal of physiology. Gastrointestinal and liver physiology

Tajima T,Murata T,Aritake K,Urade Y,Michishita M,Matsuoka T,Narumiya S,Ozaki H,Hori M

14-0112 was used in Flow cytometry/Cell sorting to investigate the possible role of PGE(2) in the LPS-inducible iNOS gene expression in murine distal ileal tissue and macrophages.

Thu Mar 01 00:00:00 EST 2012

A dynamic flux in natural killer cell subsets as a function of the duration of alcohol ingestion.

Alcoholism, clinical and experimental research

Ballas ZK,Cook RT,Shey MR,Coleman RA

14-0112 was used in Flow cytometry/Cell sorting to investigate the effect of duration of alcohol ingestion on NK cell function, showing a dynamic flux in NK cell subsets as a function of ingestion.

Tue May 01 00:00:00 EDT 2012

Microglial TIR-domain-containing adapter-inducing interferon-β (TRIF) deficiency promotes retinal ganglion cell survival and axon regeneration via nuclear factor-κB.

Journal of neuroinflammation

Lin S,Liang Y,Zhang J,Bian C,Zhou H,Guo Q,Xiong Y,Li S,Su B

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunofluorescence

Fri Feb 24 00:00:00 EST 2012

CCR2 defines a distinct population of NK cells and mediates their migration during influenza virus infection in mice.

PloS one

van Helden MJ,Zaiss DM,Sijts AJ

14-0112 was used in Flow cytometry/Cell sorting to determine the role of CCR2 in NK cell migration during intranasal influenza virus infection, showing that it defines a distinct population of NK cells and mediates their migration.

Mon Jun 10 00:00:00 EDT 2013

Conditional IFNAR1 ablation reveals distinct requirements of Type I IFN signaling for NK cell maturation and tumor surveillance.

Oncoimmunology

Mizutani T,Neugebauer N,Putz EM,Moritz N,Simma O,Zebedin-Brandl E,Gotthardt D,Warsch W,Eckelhart E,Kantner HP,Kalinke U,Lienenklaus S,Weiss S,Strobl B,Müller M,Sexl V,Stoiber D

14-0112 was used in Flow cytometry/Cell sorting to examine the role of Type 1 IFN signalling in the prevention of leukaemogenesis.

Mon Oct 01 00:00:00 EDT 2012

Extra-thymic physiological T lineage progenitor activity is exclusively confined to cells expressing either CD127, CD90, or high levels of CD117.

PloS one

Saran N,Pommerencke J,Witzlau K,Regelin M,Krueger A

14-0112 was used in Flow cytometry/Cell sorting to suggest that a physiological thymic microenvironment does not optimally support T cell differentiation from triple negative precursors.

Mon Jun 18 00:00:00 EDT 2012

An intracameral injection of antigen induces in situ chemokines and cytokines required for the generation of circulating immunoregulatory monocytes.

PloS one

Pais R,Bhowmick S,Chattopadhyay S,Lemire Y,Sharafieh R,Yadav R,O'Rourke J,Cone RE

14-0112 was used in Flow cytometry/Cell sorting to further suggest that anterior chamber-associated immune deviation is initiated as the result of a mild proinflammatory response to intracameral injection.

Wed May 01 00:00:00 EDT 2013

Pilus adhesin RrgA interacts with complement receptor 3, thereby affecting macrophage function and systemic pneumococcal disease.

mBio

Orrskog S,Rounioja S,Spadafina T,Gallotta M,Norman M,Hentrich K,Fälker S,Ygberg-Eriksson S,Hasenberg M,Johansson B,Uotila LM,Gahmberg CG,Barocchi M,Gunzer M,Normark S,Henriques-Normark B

14-0112 was used in Blocking experiments to investigate the role of the pilus-associated RrgA adhesin in pneumococcal interactions with murine and human macrophages.

Wed Dec 26 00:00:00 EST 2012

Induction of histiocytic sarcoma in mouse skeletal muscle.

PloS one

Liu J,Hettmer S,Milsom MD,Hofmann I,Hua F,Miller C,Bronson RT,Wagers AJ

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Thu Feb 07 00:00:00 EST 2013

An early reduction in Treg cells correlates with enhanced local inflammation in cutaneous leishmaniasis in CCR6-deficient mice.

PloS one

Barth T,Schmidt D,Botteron C,Nguyen TT,Ritter U,Männel DN,Lechner A

14-0112 was used in Flow cytometry/Cell sorting to analyse T cell subsets in the lymph nodes of CCR6-deficient mice over the course of Leishmania major infection.

Wed Mar 06 00:00:00 EST 2013

CD94 is essential for NK cell-mediated resistance to a lethal viral disease.

Immunity

Fang M,Orr MT,Spee P,Egebjerg T,Lanier LL,Sigal LJ

14-0112 was used in Flow cytometry/Cell sorting to show that CD94, a molecule preferentially expressed by NK cells, is essential for the resistance of C57BL/6 mice to mousepox.

Fri Apr 22 00:00:00 EDT 2011

Delivery of progenitors to the thymus limits T-lineage reconstitution after bone marrow transplantation.

Blood

Zlotoff DA,Zhang SL,De Obaldia ME,Hess PR,Todd SP,Logan TD,Bhandoola A

14-0112 was used in Flow cytometry/Cell sorting to explain why T cells are among the last of the hematopoietic lineages to recover after bone marrow transplantation (BMT).

Thu Aug 18 00:00:00 EDT 2011

Sequential desensitization of CXCR4 and S1P5 controls natural killer cell trafficking.

Blood

Mayol K,Biajoux V,Marvel J,Balabanian K,Walzer T

14-0112 was used in Flow cytometry/Cell sorting to investigate the role of CXCR4 and S1P5 in natural killer cell trafficking.

Thu Nov 03 00:00:00 EDT 2011

Recent thymic emigrants are biased against the T-helper type 1 and toward the T-helper type 2 effector lineage.

Blood

Hendricks DW,Fink PJ

14-0112 was used in Flow cytometry/Cell sorting to investigate the relationships between recent thymic emigrants and T-helper type 1 and 2 cells.

Thu Jan 27 00:00:00 EST 2011

Activation of MDL-1 (CLEC5A) on immature myeloid cells triggers lethal shock in mice.

The Journal of clinical investigation

Cheung R,Shen F,Phillips JH,McGeachy MJ,Cua DJ,Heyworth PG,Pierce RH

14-0112 was used in Flow cytometry/Cell sorting to identify the MDL-1/Syk/PI3K/Akt/eNOS pathway as a potential new target for the prevention of the progression of SIRS to shock.

Tue Nov 01 00:00:00 EDT 2011

Chemokines control naive CD8+ T cell selection of optimal lymph node antigen presenting cells.

The Journal of experimental medicine

Hickman HD,Li L,Reynoso GV,Rubin EJ,Skon CN,Mays JW,Gibbs J,Schwartz O,Bennink JR,Yewdell JW

14-0112 was used in Flow cytometry/Cell sorting to demonstrate the ability of chemokines to assist antiviral CD8(+) T cells in distinguishing between antigen presenting cells.

Mon Nov 21 00:00:00 EST 2011

Chemokines control naive CD8+ T cell selection of optimal lymph node antigen presenting cells.

The Journal of experimental medicine

Hickman HD,Li L,Reynoso GV,Rubin EJ,Skon CN,Mays JW,Gibbs J,Schwartz O,Bennink JR,Yewdell JW

14-0112 was used in Flow cytometry/Cell sorting to demonstrate the ability of chemokines to assist antiviral CD8(+) T cells in distinguishing between antigen presenting cells.

Mon Nov 21 00:00:00 EST 2011

VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses.

The Journal of experimental medicine

Wang L,Rubinstein R,Lines JL,Wasiuk A,Ahonen C,Guo Y,Lu LF,Gondek D,Wang Y,Fava RA,Fiser A,Almo S,Noelle RJ

14-0112 was used in Magnetic cell separation to show that VISTA has functional activities that are nonredundant with other Ig superfamily members and may play a role in the development of autoimmunity.

Mon Mar 14 00:00:00 EDT 2011

Transmission of endoplasmic reticulum stress and pro-inflammation from tumor cells to myeloid cells.

Proceedings of the National Academy of Sciences of the United States of America

Mahadevan NR,Rodvold J,Sepulveda H,Rossi S,Drew AF,Zanetti M

14-0112 was used in Flow cytometry/Cell sorting to suggest that tumour cells can control myeloid cells through transmissible ER stress, directing them toward a proinflammatory phenotype.

Tue Apr 19 00:00:00 EDT 2011

Superoxide production by macrophages and T cells is critical for the induction of autoreactivity and type 1 diabetes.

Diabetes

Thayer TC,Delano M,Liu C,Chen J,Padgett LE,Tse HM,Annamali M,Piganelli JD,Moldawer LL,Mathews CE

14-0112 was used in Flow cytometry/Cell sorting to determine the cellular sources of ROS that are necessary for type 1 diabetes initiation, showing that superoxide production by macrophages and T cells is critical.

Mon Aug 01 00:00:00 EDT 2011

CD11b⁺, Ly6G⁺ cells produce type I interferon and exhibit tissue protective properties following peripheral virus infection.

PLoS pathogens

Fischer MA,Davies ML,Reider IE,Heipertz EL,Epler MR,Sei JJ,Ingersoll MA,Rooijen NV,Randolph GJ,Norbury CC

14-0112 was used in Flow cytometry/Cell sorting to demonstrate that innate immune effector cells contain a peripheral poxvirus infection, preventing systemic spread of the virus.

Tue Nov 01 00:00:00 EDT 2011

Genetic labeling reveals altered turnover and stability of innate lymphocytes in latent mouse cytomegalovirus infection.

Journal of immunology (Baltimore, Md. : 1950)

Busche A,Schmitz S,Fleige H,Robbins SH,Walzer T,Stewart CA,Förster R,Messerle M,Prinz I

14-0112 was used in Flow cytometry/Cell sorting to determine that antiviral immune responses may induce sustained alterations in natural killer cell populations.

Tue Mar 01 00:00:00 EST 2011

A role for immature myeloid cells in immune senescence.

Journal of immunology (Baltimore, Md. : 1950)

Enioutina EY,Bareyan D,Daynes RA

14-0112 was used in Flow cytometry/Cell sorting to investigate the mechanisms responsible for the pathologic changes in age-associated increases in susceptibility to infectious and autoimmune diseases.

Sat Jan 15 00:00:00 EST 2011

Cutting edge: Humanized nano-proresolving medicines mimic inflammation-resolution and enhance wound healing.

Journal of immunology (Baltimore, Md. : 1950)

Norling LV,Spite M,Yang R,Flower RJ,Perretti M,Serhan CN

14-0112 was used in Flow cytometry/Cell sorting to study the temporal generation and properties of endogenous microparticles produced in evolving self-limited inflammatory exudates in vivo.

Sun May 15 00:00:00 EDT 2011

Differential expression of NLRP3 among hematopoietic cells.

Journal of immunology (Baltimore, Md. : 1950)

Guarda G,Zenger M,Yazdi AS,Schroder K,Ferrero I,Menu P,Tardivel A,Mattmann C,Tschopp J

14-0112 was used in Flow cytometry/Cell sorting to characterize NOD-like receptor pyrin domain 3 (NLRP3) expression due to importance in health and disease.

Tue Feb 15 00:00:00 EST 2011

The role of CD14 in neutrophil recruitment within the liver microcirculation during endotoxemia.

Journal of immunology (Baltimore, Md. : 1950)

McAvoy EF,McDonald B,Parsons SA,Wong CH,Landmann R,Kubes P

14-0112 was used in Flow cytometry/Cell sorting to demonstrate that liver microcirculation possesses a unique CD14-independent mechanism of LPS detection and activation of neutrophil recruitment.

Tue Feb 15 00:00:00 EST 2011

A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease.

Human molecular genetics

McDonald DA,Shenkar R,Shi C,Stockton RA,Akers AL,Kucherlapati MH,Kucherlapati R,Brainer J,Ginsberg MH,Awad IA,Marchuk DA

14-0112 was used in Immunohistochemistry to attempt to improve the penetrance of a model of cerebral cavernous malformations.

Sat Jan 15 00:00:00 EST 2011

Generation of mature murine monocytes from heterogeneous bone marrow and description of their properties.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

Francke A,Herold J,Weinert S,Strasser RH,Braun-Dullaeus RC

14-0112 was used in Functional assays to describe a novel approach to efficiently differentiate large numbers of mature inflammatory monocytes from heterogeneous bone marrow cell suspensions.

Thu Sep 01 00:00:00 EDT 2011

PAD4-mediated neutrophil extracellular trap formation is not required for immunity against influenza infection.

PloS one

Hemmers S,Teijaro JR,Arandjelovic S,Mowen KA

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Tue Nov 15 00:00:00 EST 2011

Bioluminescent imaging reveals divergent viral pathogenesis in two strains of Stat1-deficient mice, and in αßγ interferon receptor-deficient mice.

PloS one

Pasieka TJ,Collins L,O'Connor MA,Chen Y,Parker ZM,Berwin BL,Piwnica-Worms DR,Leib DA

14-0112 was used in Flow cytometry/Cell sorting to examine HSV-1 pathogenesis in Stat1(-/-) mice and in IFNαβγR(-/-) mice, showing divergent viral pathogenesis between mouse strains.

Tue Feb 14 00:00:00 EST 2012

Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis.

Nature communications

Mkhikian H,Grigorian A,Li CF,Chen HL,Newton B,Zhou RW,Beeton C,Torossian S,Tatarian GG,Lee SU,Lau K,Walker E,Siminovitch KA,Chandy KG,Yu Z,Dennis JW,Demetriou M

14-0112 was used in Flow cytometry/Cell sorting to discover that genetic and the environment converge to dysregulate N-glycosylation in multiple sclerosis.

Tue Sep 20 00:00:00 EDT 2011

Lymphoid organ-resident dendritic cells exhibit unique transcriptional fingerprints based on subset and site.

PloS one

Elpek KG,Bellemare-Pelletier A,Malhotra D,Reynoso ED,Lukacs-Kornek V,DeKruyff RH,Turley SJ

14-0112 was used in Flow cytometry/Cell sorting to investigate whether local environments can influence the transcriptome of DC subsets, showing that lymphoid organ-resident dendritic cells exhibit unique transcriptomes based on site.

Fri Feb 24 00:00:00 EST 2012

Generation and evaluation of an IPTG-regulated version of Vav-gene promoter for mouse transgenesis.

PloS one

Grespi F,Ottina E,Yannoutsos N,Geley S,Villunger A

14-0112 was used in Flow cytometry/Cell sorting to evaluate the suitability of the lac-operon/lac-repressor (lacO/lacI) system for the regulation of the Vav-gene promoter, and the importance of IPTG.

Mon Mar 21 00:00:00 EDT 2011

FTY720 reduces post-ischemic brain lymphocyte influx but does not improve outcome in permanent murine cerebral ischemia.

PloS one

Liesz A,Sun L,Zhou W,Schwarting S,Mracsko E,Zorn M,Bauer H,Sommer C,Veltkamp R

14-0112 was used in Flow cytometry/Cell sorting to detect a reduction of lymphocyte brain invasion by FTY720.

Fri Oct 14 00:00:00 EDT 2011

Glycosidic Tn-based vaccines targeting dermal dendritic cells favor germinal center B-cell development and potent antibody response in the absence of adjuvant.

Blood

Freire T,Zhang X,Dériaud E,Ganneau C,Vichier-Guerre S,Azria E,Launay O,Lo-Man R,Bay S,Leclerc C

14-0112 was used in Flow cytometry/Cell sorting to study dendritic cell antigen uptake and presentation by targeting the antigen receptor, macrophage galactose-type lectin (MGL), with tumor-associated Tn antigens.

Thu Nov 04 00:00:00 EDT 2010

Lymphotoxin-alpha contributes to lymphangiogenesis.

Blood

Mounzer RH,Svendsen OS,Baluk P,Bergman CM,Padera TP,Wiig H,Jain RK,McDonald DM,Ruddle NH

14-0112 was used in Immunohistochemistry-wholemount to investigate the role of Lymphotoxin-α in the function of lymphatic vessels.

Thu Sep 23 00:00:00 EDT 2010

Angiotensin II sustains brain inflammation in mice via TGF-beta.

The Journal of clinical investigation

Lanz TV,Ding Z,Ho PP,Luo J,Agrawal AN,Srinagesh H,Axtell R,Zhang H,Platten M,Wyss-Coray T,Steinman L

14-0112 was used in Flow cytometry/Cell sorting to identify angiotensin II as a paracrine mediator, sustaining inflammation in the CNS via TGF-β.

Sun Aug 01 00:00:00 EDT 2010

The adaptor molecule CARD9 is essential for tuberculosis control.

The Journal of experimental medicine

Dorhoi A,Desel C,Yeremeev V,Pradl L,Brinkmann V,Mollenkopf HJ,Hanke K,Gross O,Ruland J,Kaufmann SH

14-0112 was used in Flow cytometry/Cell sorting to investigate the role of CARD9 in tuberculosis.

Mon Apr 12 00:00:00 EDT 2010

MHC class I-deficient natural killer cells acquire a licensed phenotype after transfer into an MHC class I-sufficient environment.

The Journal of experimental medicine

Elliott JM,Wahle JA,Yokoyama WM

14-0112 was used in Flow cytometry/Cell sorting to investigate whether licensing is developmentally determined in the bone marrow, showing that MHC class I ligands are not absolutely required for licensing.

Mon Sep 27 00:00:00 EDT 2010

CD207+ CD103+ dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells.

The Journal of experimental medicine

Henri S,Poulin LF,Tamoutounour S,Ardouin L,Guilliams M,de Bovis B,Devilard E,Viret C,Azukizawa H,Kissenpfennig A,Malissen B

14-0112 was used in Flow cytometry/Cell sorting to revisit the transfer of antigen that occurs between keratinocytes and the five distinguishable skin DC subsets and stress the high degree of functional specialization that exists among them.

Mon Jan 18 00:00:00 EST 2010

Neuroprotection in a rabbit model of intraventricular haemorrhage by cyclooxygenase-2, prostanoid receptor-1 or tumour necrosis factor-alpha inhibition.

Brain : a journal of neurology

Vinukonda G,Csiszar A,Hu F,Dummula K,Pandey NK,Zia MT,Ferreri NR,Ungvari Z,LaGamma EF,Ballabh P

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunofluorescence

Sun Aug 01 00:00:00 EDT 2010

Notch dimerization is required for leukemogenesis and T-cell development.

Genes & development

Liu H,Chi AW,Arnett KL,Chiang MY,Xu L,Shestova O,Wang H,Li YM,Bhandoola A,Aster JC,Blacklow SC,Pear WS

14-0112 was used in Flow cytometry/Cell sorting to show that dimeric Notch transcriptional complexes are required for T-cell maturation and leukemic transformation but are dispensable for T-cell fate specification from a multipotential precursor.

Mon Nov 01 00:00:00 EDT 2010

Measles virus infection of alveolar macrophages and dendritic cells precedes spread to lymphatic organs in transgenic mice expressing human signaling lymphocytic activation molecule (SLAM, CD150).

Journal of virology

Ferreira CS,Frenzke M,Leonard VH,Welstead GG,Richardson CD,Cattaneo R

14-0112 was used in Immunofluorescence to identify the cells that support primary measles infection before systemic spread.

Mon Mar 01 00:00:00 EST 2010

Angiopoietin-2-driven vascular remodeling in airway inflammation.

The American journal of pathology

Tabruyn SP,Colton K,Morisada T,Fuxe J,Wiegand SJ,Thurston G,Coyle AJ,Connor J,McDonald DM

14-0112 was used in Immunohistochemistry to determine the precise contribution of Ang2 to the transformation of capillaries into venules.

Wed Dec 01 00:00:00 EST 2010

Dendritic cell (DC)-specific targeting reveals Stat3 as a negative regulator of DC function.

Journal of immunology (Baltimore, Md. : 1950)

Melillo JA,Song L,Bhagat G,Blazquez AB,Plumlee CR,Lee C,Berin C,Reizis B,Schindler C

14-0112 was used in Flow cytometry/Cell sorting to directly examine the role Stat3 plays in regulating dendritic cell activity.

Mon Mar 01 00:00:00 EST 2010

CD155 is involved in negative selection and is required to retain terminally maturing CD8 T cells in thymus.

Journal of immunology (Baltimore, Md. : 1950)

Qiu Q,Ravens I,Seth S,Rathinasamy A,Maier MK,Davalos-Misslitz A,Forster R,Bernhardt G

14-0112 was used in Magnetic cell separation to investigate the role of CD155 in negative selection of thymocytes.

Mon Feb 15 00:00:00 EST 2010

Cutting edge: adaptive versus innate receptor signals selectively control the pool sizes of murine IFN-γ- or IL-17-producing γδ T cells upon infection.

Journal of immunology (Baltimore, Md. : 1950)

Ribot JC,Chaves-Ferreira M,d'Orey F,Wencker M,Gonçalves-Sousa N,Decalf J,Simas JP,Hayday AC,Silva-Santos B

14-0112 was used in Flow cytometry/Cell sorting to investigate the properties of γδ T lymphocytes for adaptive and innate immunity.

Wed Dec 01 00:00:00 EST 2010

B-cell homeostasis requires complementary CD22 and BLyS/BR3 survival signals.

International immunology

Smith SH,Haas KM,Poe JC,Yanaba K,Ward CD,Migone TS,Tedder TF

14-0112 was used in Flow cytometry/Cell sorting to support a model whereby B cells must integrate varied signals, including those from the BLyS- BR3 axis, CD22-ligand binding and antigen-receptor-mediated tonic signaling for their homeostatic maintenance in vivo.

Sun Aug 01 00:00:00 EDT 2010

Forkhead box M1 transcription factor is required for macrophage recruitment during liver repair.

Molecular and cellular biology

Ren X,Zhang Y,Snyder J,Cross ER,Shah TA,Kalin TV,Kalinichenko VV

14-0112 was used in Flow cytometry/Cell sorting to study how Foxm1 is critical for liver repair and is required for the recruitment of monocytes to the injured liver.

Mon Nov 01 00:00:00 EDT 2010

Induction of human blood group a antigen expression on mouse cells, using lentiviral gene transduction.

Human gene therapy

Fan X,Lang H,Zhou X,Zhang L,Yin R,Maciejko J,Giannitsos V,Motyka B,Medin JA,Platt JL,West LJ

14-0112 was used in Immunohistochemistry to determine the feasibility of developing a murine model of the ABO histo-blood group system.

Thu Jul 01 00:00:00 EDT 2010

Cryptococcus neoformans variants generated by phenotypic switching differ in virulence through effects on macrophage activation.

Infection and immunity

Guerrero A,Jain N,Wang X,Fries BC

14-0112 was used in Flow cytometry/Cell sorting to investigate the interaction between macrophages and cells from smooth-colony or mucoid-colony variants arising from phenotypic switching of Cryptococcus neoformans.

Mon Mar 01 00:00:00 EST 2010

A novel heat-shock protein coinducer boosts stress protein Hsp70 to activate T cell regulation of inflammation in autoimmune arthritis.

Arthritis and rheumatism

Wieten L,van der Zee R,Spiering R,Wagenaar-Hilbers J,van Kooten P,Broere F,van Eden W

14-0112 was used in Neutralization to study whether the boosting of endogenous heat-shock protein expression can restore effective immunoregulation through T cells specific for stress proteins.

Thu Apr 01 00:00:00 EDT 2010

Regulation of granulocyte and macrophage populations of murine bone marrow cells by G-CSF and CD137 protein.

PloS one

Jiang D,Schwarz H

14-0112 was used in Flow cytometry/Cell sorting to confirm the role of CD137 ligand signalling in regulating myelopoiesis, and demonstrate that this growth promoting influence is restricted to the monocytic lineage.

Mon Dec 13 00:00:00 EST 2010

Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche.

Cancer cell

Erler JT,Bennewith KL,Cox TR,Lang G,Bird D,Koong A,Le QT,Giaccia AJ

14-0112 was used in Immunofluorescence to demonstrate a critical role for LOX in premetastatic niche formation.

Tue Jan 06 00:00:00 EST 2009

Wnt7a activates the planar cell polarity pathway to drive the symmetric expansion of satellite stem cells.

Cell stem cell

Le Grand F,Jones AE,Seale V,Scimè A,Rudnicki MA

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Fri Jun 05 00:00:00 EDT 2009

Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury.

The Journal of clinical investigation

Heymann F,Meyer-Schwesinger C,Hamilton-Williams EE,Hammerich L,Panzer U,Kaden S,Quaggin SE,Floege J,Gröne HJ,Kurts C

14-0112 was used in Flow cytometry/Cell sorting to investigate the role of several immune cell types within tubulointerstitial mononuclear cell infiltrates in the progression of kidney disease.

Fri May 01 00:00:00 EDT 2009

Oncogenic Kras initiates leukemia in hematopoietic stem cells.

PLoS biology

Sabnis AJ,Cheung LS,Dail M,Kang HC,Santaguida M,Hermiston ML,Passegué E,Shannon K,Braun BS

14-0112 was used in Flow cytometry/Cell sorting to conclude that MPD-initiating activity is restricted to the HSC compartment in Kras(G12D) mice.

Tue Mar 17 00:00:00 EDT 2009

The NOD/RIP2 pathway is essential for host defenses against Chlamydophila pneumoniae lung infection.

PLoS pathogens

Shimada K,Chen S,Dempsey PW,Sorrentino R,Alsabeh R,Slepenkin AV,Peterson E,Doherty TM,Underhill D,Crother TR,Arditi M

14-0112 was used in Flow cytometry/Cell sorting to investigate the role of the Nod/Rip2 pathway in responses to Chlamydophila pneumoniae infection, showing that it is essential for host defences against pneumonia.

Wed Apr 01 00:00:00 EDT 2009

Involvement of IQGAP3, a regulator of Ras/ERK-related cascade, in hepatocyte proliferation in mouse liver regeneration and development.

Journal of cellular physiology

Kunimoto K,Nojima H,Yamazaki Y,Yoshikawa T,Okanoue T,Tsukita S

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunofluorescence

Tue Sep 01 00:00:00 EDT 2009

Critical roles of lysosomal acid lipase in T cell development and function.

The American journal of pathology

Qu P,Du H,Wilkes DS,Yan C

14-0112-82 was used in Flow Cytometry to conclude that the altered development and function of lal(-/-) T cells contributes to disease formation in various organs during LAL deficiency.

Sun Mar 01 00:00:00 EST 2009

SIGNR1-negative red pulp macrophages protect against acute streptococcal sepsis after Leishmania donovani-induced loss of marginal zone macrophages.

The American journal of pathology

Kirby AC,Beattie L,Maroof A,van Rooijen N,Kaye PM

14-0112 was used in Flow cytometry/Cell sorting to show the protective activity of SIGNR1(+) marginal zone macrophages can be compensated for by activated red pulp macrophages.

Tue Sep 01 00:00:00 EDT 2009

alpha5beta1 Integrin blockade inhibits lymphangiogenesis in airway inflammation.

The American journal of pathology

Okazaki T,Ni A,Ayeni OA,Baluk P,Yao LC,Vossmeyer D,Zischinsky G,Zahn G,Knolle J,Christner C,McDonald DM

14-0112 was used in Immunohistochemistry-wholemount to investigate the role of integrin alpha5beta1 in remodelling blood and lymphatic vessels.

Mon Jun 01 00:00:00 EDT 2009

Inflammation recapitulates the ontogeny of lymphoid stromal cells.

Journal of immunology (Baltimore, Md. : 1950)

Peduto L,Dulauroy S,Lochner M,Späth GF,Morales MA,Cumano A,Eberl G

14-0112 was used in Functional assays to show that LS cells are both programmed during ontogeny and reinduced during inflammation.

Fri May 01 00:00:00 EDT 2009

Chemokine-like receptor-1 expression by central nervous system-infiltrating leukocytes and involvement in a model of autoimmune demyelinating disease.

Journal of immunology (Baltimore, Md. : 1950)

Graham KL,Zabel BA,Loghavi S,Zuniga LA,Ho PP,Sobel RA,Butcher EC

14-0112 was used in Flow cytometry/Cell sorting to investigate the involvement of chemokine-like receptor-1 in experimental autoimmune encephalomyelitis.

Sun Nov 15 00:00:00 EST 2009

Induction of distinct TLR2-mediated proinflammatory and proadhesive signaling pathways in response to Porphyromonas gingivalis fimbriae.

Journal of immunology (Baltimore, Md. : 1950)

Hajishengallis G,Wang M,Liang S

14-0112 was used in Blocking experiments to demonstrate that Porphyromonas gingivalis fimbriae activate two distinct TLR2 pathways mediating proinflammatory or proadhesive effects.

Mon Jun 01 00:00:00 EDT 2009

Chlamydial heat shock protein 60 induces acute pulmonary inflammation in mice via the Toll-like receptor 4- and MyD88-dependent pathway.

Infection and immunity

Bulut Y,Shimada K,Wong MH,Chen S,Gray P,Alsabeh R,Doherty TM,Crother TR,Arditi M

14-0112 was used in Flow cytometry/Cell sorting to suggest that cHSP60 causes lung inflammation and dendritic cell activation via Toll-like receptor 4 and MyD88.

Wed Jul 01 00:00:00 EDT 2009

Peripheral dendritic cells are essential for both the innate and adaptive antiviral immune responses in the central nervous system.

Virology

Steel CD,Hahto SM,Ciavarra RP

14-0112-82 was used in Flow Cytometry to study the adaptive primary antiviral immune response in the CNS and the effect of dendritic cells upon this in vivo.

Sat Apr 25 00:00:00 EDT 2009

Reporter gene-expressing bone marrow-derived stromal cells are immune-tolerated following implantation in the central nervous system of syngeneic immunocompetent mice.

BMC biotechnology

Bergwerf I,De Vocht N,Tambuyzer B,Verschueren J,Reekmans K,Daans J,Ibrahimi A,Van Tendeloo V,Chatterjee S,Goossens H,Jorens PG,Baekelandt V,Ysebaert D,Van Marck E,Berneman ZN,Linden AV,Ponsaerts P

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Immunohistochemistry

Wed Jan 07 00:00:00 EST 2009

Id1 represses osteoclast-dependent transcription and affects bone formation and hematopoiesis.

PloS one

Chan AS,Jensen KK,Skokos D,Doty S,Lederman HK,Kaplan RN,Rafii S,Rivella S,Lyden D

14-0112 was used in Flow cytometry/Cell sorting to identify Id1 as crucial for the dynamic cross-talk between bone and bone marrow haematopoietic cells.

Tue Nov 24 00:00:00 EST 2009

Malarial hemozoin is a Nalp3 inflammasome activating danger signal.

PloS one

Dostert C,Guarda G,Romero JF,Menu P,Gross O,Tardivel A,Suva ML,Stehle JC,Kopf M,Stamenkovic I,Corradin G,Tschopp J

14-0112 was used in Flow cytometry/Cell sorting to hypothesized that hemozoin could activate the Nalp3 inflammasome.

Tue Aug 04 00:00:00 EDT 2009

The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues.

Nature immunology

Waskow C,Liu K,Darrasse-Jèze G,Guermonprez P,Ginhoux F,Merad M,Shengelia T,Yao K,Nussenzweig M

14-0112-82 was used in Immunohistochemistry to investigate the hematopoietic growth factors regulating dendritic development.

Sun Jun 01 00:00:00 EDT 2008

The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues.

Nature immunology

Waskow C,Liu K,Darrasse-Jèze G,Guermonprez P,Ginhoux F,Merad M,Shengelia T,Yao K,Nussenzweig M

14-0112-82 was used in Immunohistochemistry to investigate the hematopoietic growth factors regulating dendritic development.

Sun Jun 01 00:00:00 EDT 2008

The Th17-ELR+ CXC chemokine pathway is essential for the development of central nervous system autoimmune disease.

The Journal of experimental medicine

Carlson T,Kroenke M,Rao P,Lane TE,Segal B

14-0112 was used in Flow cytometry/Cell sorting to demonstrate that ELR(+) CXC chemokines and CXCR2-expressing polymorphonuclear leukocytes are required for the development of experimental autoimmune encephalomyelitis.

Mon Apr 14 00:00:00 EDT 2008

CD40 ligand promotes Mac-1 expression, leukocyte recruitment, and neointima formation after vascular injury.

The American journal of pathology

Li G,Sanders JM,Bevard MH,Sun Z,Chumley JW,Galkina EV,Ley K,Sarembock IJ

14-0112 was used in Flow cytometry/Cell sorting to study the function of CD40 ligand in neointima formation following vascular injury in an atherogenic animal model.

Tue Apr 01 00:00:00 EDT 2008

Lipid raft-dependent uptake, signalling and intracellular fate of Porphyromonas gingivalis in mouse macrophages.

Cellular microbiology

Wang M,Hajishengallis G

14-0112 was used in Flow cytometry/Cell sorting to determine whether the oral pathogen Porphyromonas gingivalis enters macrophages via lipid rafts.

Wed Oct 01 00:00:00 EDT 2008

Phospholipase Cgamma2 mediates RANKL-stimulated lymph node organogenesis and osteoclastogenesis.

The Journal of biological chemistry

Chen Y,Wang X,Di L,Fu G,Chen Y,Bai L,Liu J,Feng X,McDonald JM,Michalek S,He Y,Yu M,Fu YX,Wen R,Wu H,Wang D

Published figure using CD11b monoclonal antibody (Product # 14-0112-82) in Flow Cytometry

Fri Oct 24 00:00:00 EDT 2008

Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling.

Proceedings of the National Academy of Sciences of the United States of America

Tsuji M,Shinkura R,Kuroda K,Yabe D,Honjo T

14-0112-82 was used in Flow Cytometry to o investigate where and how Notch regulates early T cell differentiation by using specific up-regulation of Notch signaling by Mint knockout.

Tue Jan 30 00:00:00 EST 2007

N-glycan processing deficiency promotes spontaneous inflammatory demyelination and neurodegeneration.

The Journal of biological chemistry

Lee SU,Grigorian A,Pawling J,Chen IJ,Gao G,Mozaffar T,McKerlie C,Demetriou M

14-0112 was used in Flow cytometry/Cell sorting to identify hypomorphic Golgi processing as an inherited trait that determines susceptibility to EAE and provides a unique spontaneous model of MS.

Fri Nov 16 00:00:00 EST 2007

Identification of a radio-resistant and cycling dermal dendritic cell population in mice and men.

The Journal of experimental medicine

Bogunovic M,Ginhoux F,Wagers A,Loubeau M,Isola LM,Lubrano L,Najfeld V,Phelps RG,Grosskreutz C,Scigliano E,Frenette PS,Merad M

14-0112 was used in Flow cytometry/Cell sorting to explore dermal DC homeostasis in mice and humans both in the steady state and after haematopoietic cell transplantation.

Mon Nov 27 00:00:00 EST 2006

Porphyromonas gingivalis fimbriae proactively modulate beta2 integrin adhesive activity and promote binding to and internalization by macrophages.

Infection and immunity

Hajishengallis G,Wang M,Harokopakis E,Triantafilou M,Triantafilou K

14-0112 was used in Binding experiments to show that P. gingivalis fimbriae function as both an activator and a ligand of CD11b/CD18.

Sun Oct 01 00:00:00 EDT 2006

Bioinformatics

Protein Aliases: CD11 antigen-like family member B; CD11B (p170); cell surface glycoprotein MAC-1 alpha subunit; cell surface glycoprotein MAC-1 subunit alpha; complement component receptor 3 alpha-a; complement receptor type 3; CR-3 alpha chain; integrin alpha-M; leukocyte adhesion receptor MO1; Mac-1 alpha; Mac-1 alpha (Mac1A); macrophage antigen alpha; MGC117044

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Gene Aliases: Cd11b; CD11b/CD18; CR3; CR3A; F730045J24Rik; Ly-40; Mac-1; Mac-1a; MAC1

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Entrez Gene ID: (Mouse) 16409

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Function(s)

opsonin binding glycoprotein binding heparin binding heparan sulfate proteoglycan binding metal ion binding protein heterodimerization activity integrin

Process(es)

leukocyte migration involved in inflammatory response cell adhesion leukocyte cell-cell adhesion integrin-mediated signaling pathway microglia development single organismal cell-cell adhesion neutrophil chemotaxis cellular extravasation activated T cell proliferation

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CD11b Monoclonal Antibody (M1/70), eBioscience™

CD11b Antibody (14-0112-82) in IHC (P)

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14-0112-82

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunohistochemistry (Frozen) (IHC (F))

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ELISA (ELISA)

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In vitro Assay (IV)

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