Product References
Stromal niche inflammation mediated by IL-1 signalling is a targetable driver of haematopoietic ageing.
Nature cell biology
Mitchell CA,Verovskaya EV,Calero-Nieto FJ,Olson OC,Swann JW,Wang X,Hérault A,Dellorusso PV,Zhang SY,Svendsen AF,Pietras EM,Bakker ST,Ho TT,Göttgens B,Passegué E
11-0112-82 was used in Flow cytometry/Cell sorting to characterize the inflammatory milieu that drives both niche and haematopoietic remodelling.
Sun Jan 01 00:00:00 EST 2023
Deciphering the mechanism of Peptostreptococcus anaerobius-induced chemoresistance in colorectal cancer: the important roles of MDSC recruitment and EMT activation.
Frontiers in immunology
Gu J,Lv X,Li W,Li G,He X,Zhang Y,Shi L,Zhang X
11-0112-82 was used in Flow Cytometry to highlight that targeting P. anaerobius might be a novel therapeutic strategy to overcome chemoresistance in the treatment of CRC.
Tue Oct 03 00:00:00 EDT 2023
Gut microbiota-derived nicotinamide mononucleotide alleviates acute pancreatitis by activating pancreatic SIRT3 signalling.
British journal of pharmacology
Liu LW,Xie Y,Li GQ,Zhang T,Sui YH,Zhao ZJ,Zhang YY,Yang WB,Geng XL,Xue DB,Chen H,Wang YW,Lu TQ,Shang LR,Li ZB,Li L,Sun B
11-0112-82 was used in Flow cytometry/Cell sorting to investigate the effect of gut microbiota and microbiota-derived metabolites on AP and further clarify the mechanisms associated with pancreatic damage and inflammation.
Wed Mar 01 00:00:00 EST 2023
Macrophage Reprogramming via the Modulation of Unfolded Protein Response with siRNA-Loaded Magnetic Nanoparticles in a TAM-like Experimental Model.
Pharmaceutics
D'Urso A,Oltolina F,Borsotti C,Prat M,Colangelo D,Follenzi A
11-0112-82 was used in Flow cytometry/Cell sorting to provide a novel strategy for the development of new tumor immunotherapies in vivo.
Mon Jun 12 00:00:00 EDT 2023
Intranasal Delivery of Endothelial Cell-Derived Extracellular Vesicles with Supramolecular Gel Attenuates Myocardial Ischemia-Reperfusion Injury.
International journal of nanomedicine
Wang J,Tan Y,Dai Y,Hu K,Tan X,Jiang S,Li G,Zhang X,Kang L,Wang X,Xu B
11-0112-82 was used in Flow Cytometry to demonstrate that the combination of extracellular vesicles and hydrogel has a better absorption efficiency in the nasal cavity, which can improve myocardial ischemia-reperfusion injury by inhibiting inflammatory reactions and protecting endothelial function.
Thu Oct 05 00:00:00 EDT 2023
Obesity impairs cardiolipin-dependent mitophagy and therapeutic intercellular mitochondrial transfer ability of mesenchymal stem cells.
Cell death & disease
Sagar S,Faizan MI,Chaudhary N,Singh V,Singh P,Gheware A,Sharma K,Azmi I,Singh VP,Kharya G,Mabalirajan U,Agrawal A,Ahmad T,Sinha Roy S
11-0112-82 was used in Flow cytometry/Cell sorting to provide the first comprehensive molecular understanding of impaired mitophagy in obese-derived MSCs and highlight the importance of pharmacological modulation of these cells for therapeutic intervention.
Sat May 13 00:00:00 EDT 2023
CD8+ T Cells Trigger Auricular Dermatitis and Blepharitis in Mice after Zika Virus Infection in the Absence of CD4+ T Cells.
The Journal of investigative dermatology
Lee CY,Carissimo G,Teo TH,Tong SJM,Chang ZW,Rajarethinam R,Chua TK,Chen Z,Chee RS,Tay A,Howland SW,Ang KS,Chen J,Renia L,Ng LFP
11-0112-82 was used in Flow cytometry/Cell sorting to suggest a role for CD8+ T-cell?associated pathologies after ZIKV infection in CD4+ T-cell?immunodeficient patients.
Thu Jun 01 00:00:00 EDT 2023
Klebsiella pneumoniae Induces Inflammatory Bowel Disease Through Caspase-11-Mediated IL18 in the Gut Epithelial Cells.
Cellular and molecular gastroenterology and hepatology
Zhang Q,Su X,Zhang C,Chen W,Wang Y,Yang X,Liu D,Zhang Y,Yang R
11-0112-82 was used in Flow Cytometry to show that lipopolysaccharide from KLPJ could bind with caspase-11 to induce mature IL18 in mouse and human colon organoids.
Thu Feb 23 00:00:00 EST 2023
Gasdermin D inhibition ameliorates neutrophil mediated brain damage in acute ischemic stroke.
Cell death discovery
Hu R,Liang J,Ding L,Zhang W,Wang Y,Zhang Y,Zhang D,Pei L,Liu X,Xia Z,Xu Y,Song B
11-0112-82 was used in Flow cytometry/Cell sorting to provide a new viewpoint on the immunological modulation of neutrophils after MCAO and suggest that suppression of GSDMD may relieve the neuroinflammatory load, thereby providing a potential treatment strategy for stroke.
Wed Feb 08 00:00:00 EST 2023
Monocytes reprogrammed by tumor microparticle vaccine inhibit tumorigenesis and tumor development.
Cancer nanotechnology
Sun W,Dai L,Cao Y,Pan P,Zhi L,Wang X,Yuan X,Gao Z,Guo S,Liu G,Yin J,Xie L,Wang L,Wang Y,Li W,Li H,Jia Y
11-0112-82 was used in Flow cytometry/Cell sorting to provide novel vaccination strategy for the development of tumor vaccines and facilitate the application of T-MPs for clinic oncotherapy.
Tue Apr 25 00:00:00 EDT 2023
Dendritic cell Piezo1 directs the differentiation of TH1 and Treg cells in cancer.
eLife
Wang Y,Yang H,Jia A,Wang Y,Yang Q,Dong Y,Hou Y,Cao Y,Dong L,Bi Y,Liu G
11-0112-82 was used in Flow cytometry/Cell sorting to demonstrate the role of the dendritic cells-based mechanical regulation of immunopathology in directing T cell lineage commitment in tumor microenvironments.
Mon Aug 22 00:00:00 EDT 2022
Type 1 piliated uropathogenic Escherichia coli hijack the host immune response by binding to CD14.
eLife
Tomasek K,Leithner A,Glatzova I,Lukesch MS,Guet CC,Sixt M
11-0112-82 was used in flow cytometry to identify CD14, the major co-receptor for lipopolysaccharide detection, on mouse dendritic cells (DCs) as a binding partner of FimH, the protein located at the tip of the type 1 pilus of Escherichia coli.
Tue Jul 26 00:00:00 EDT 2022
Overexpression of mir-135b and mir-210 in mesenchymal stromal cells for the enrichment of extracellular vesicles with angiogenic factors.
PloS one
Vieira JMF,Zamproni LN,Wendt CHC,Rocha de Miranda K,Lindoso RS,Won Han S
11-0112-82 was used in Flow cytometry/Cell sorting to show that extracellular vesicle cargo can be modified by lentiviral vectors to enrich specific miRNAs to achieve a specific angiogenic potential.
Thu Aug 18 00:00:00 EDT 2022
Lin28B-high breast cancer cells promote immune suppression in the lung pre-metastatic niche via exosomes and support cancer progression.
Nature communications
Qi M,Xia Y,Wu Y,Zhang Z,Wang X,Lu L,Dai C,Song Y,Xu K,Ji W,Zhan L
11-0112-82 was used in Flow Cytometry to demonstrate that Lin28B promotes lung metastasis of breast cancer by building an immune-suppressive pre-metastatic niche.
Wed Feb 16 00:00:00 EST 2022
Lysosomal acid lipase, CSF1R, and PD-L1 determine functions of CD11c+ myeloid-derived suppressor cells.
JCI insight
Zhao T,Liu S,Ding X,Johnson EM,Hanna NH,Singh K,Sen CK,Wan J,Du H,Yan C
11-0112-82 was used in Flow cytometry/Cell sorting to investigate if CD11c+ cells switched their functions to immune suppression and tumor growth stimulation through CSF1R/PD-L1 upregulation and metabolic reprogramming.
Thu Sep 08 00:00:00 EDT 2022
Combination of a STAT3 inhibitor with anti-PD-1 immunotherapy is an effective treatment regimen for a vemurafenib-resistant melanoma.
Molecular therapy oncolytics
Kim TW,Kim Y,Keum H,Jung W,Kang M,Jon S
11-0112-82 was used in Flow cytometry/Cell sorting to investigate the antitumor efficacy and TME remodeling by APTSTAT3-9R, a cell-permeable STAT3 inhibitory peptide, as a strategy to treat vemurafenib-resistant melanoma.
Thu Sep 15 00:00:00 EDT 2022
Growth arrest-specific protein 2 (GAS2) interacts with CXCR4 to promote T-cell leukemogenesis partially via c-MYC.
Molecular oncology
Ma W,Wan Y,Zhang J,Yao J,Wang Y,Lu J,Liu H,Huang X,Zhang X,Zhou H,He Y,Wu D,Wang J,Zhao Y
11-0112-82 was used in Flow cytometry/Cell sorting to suggest that targeting the GAS2/CXCR4 axis is a potential therapeutic strategy for T-ALL.
Sat Oct 01 00:00:00 EDT 2022
Silver Nanoparticles Inhibit Metastasis of 4T1 Tumor in Mice after Intragastric but Not Intravenous Administration.
Materials (Basel, Switzerland)
Brzóska K,Wojewódzka M,Szczygiel M,Drzał A,Sniegocka M,Michalczyk-Wetula D,Biela E,Elas M,Kucińska M,Piotrowska-Kempisty H,Kapka-Skrzypczak L,Murias M,Urbańska K,Kruszewski M
11-0112-82 was used in Immunohistochemistry (Frozen) to support the previous findings that antitumor AgNPs activity may depend on the activation of the immune system and not on the direct action of AgNPs on cancer cells.
Fri May 27 00:00:00 EDT 2022
Photoreceptor protection by mesenchymal stem cell transplantation identifies exosomal MiR-21 as a therapeutic for retinal degeneration.
Cell death and differentiation
Deng CL,Hu CB,Ling ST,Zhao N,Bao LH,Zhou F,Xiong YC,Chen T,Sui BD,Yu XR,Hu CH
11-0112-82 was used in Flow cytometry/Cell sorting to discover that intravitreal MSCT counteracted photoreceptor apoptosis and alleviate retinal morphological and functional degeneration in a mouse model of photoreceptor loss induced by N-methyl-N-nitrosourea (MNU).
Mon Mar 01 00:00:00 EST 2021
Mice with a specific deficiency of Pfkfb3 in myeloid cells are protected from hypoxia-induced pulmonary hypertension.
British journal of pharmacology
Wang L,Zhang X,Cao Y,Ma Q,Mao X,Xu J,Yang Q,Zhou Y,Lucas R,Fulton DJ,Su Y,Barman SA,Hong M,Liu Z,Huo Y
11-0112-82 was used in Flow cytometry/Cell sorting to investigate the effect of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKBF3), a critical enzyme of macrophage glycolysis, on PH development.
Mon Mar 01 00:00:00 EST 2021
Serum- and Glucocorticoid-Inducible Kinase 1 Promotes Alternative Macrophage Polarization and Restrains Inflammation through FoxO1 and STAT3 Signaling.
Journal of immunology (Baltimore, Md. : 1950)
Ren J,Han X,Lohner H,Liang R,Liang S,Wang H
11-0112-82 was used in Flow cytometry/Cell sorting to demonstrate that SGK1 is critical for macrophage polarization and periodontal bone loss, and to propose a bifurcated signaling circuit by which SGK1 promotes alternative, while suppressing inflammatory, macrophage polarization.
Thu Jul 01 00:00:00 EDT 2021
Differential activation of Ca2+ influx channels modulate stem cell potency, their proliferation/viability and tissue regeneration.
NPJ Regenerative medicine
Ahamad N,Sun Y,Nascimento Da Conceicao V,Xavier Paul Ezhilan CRD,Natarajan M,Singh BB
11-0112-82 was used in Immunohistochemistry to establish the molecular identity of the calcium channel in MSCs and also show their role in modulating stem cell function.
Wed Oct 20 00:00:00 EDT 2021
ELMO1 signaling is a promoter of osteoclast function and bone loss.
Nature communications
Arandjelovic S,Perry JSA,Zhou M,Ceroi A,Smirnov I,Walk SF,Shankman LS,Cambré I,Onengut-Gumuscu S,Elewaut D,Conrads TP,Ravichandran KS
11-0112-82 was used in Flow Cytometry to identify ELMO1 as a signaling hub that regulates osteoclast function and bone loss, with relevance to osteoporosis and arthritis.
Tue Aug 17 00:00:00 EDT 2021
USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade.
Nature communications
Yang Z,Xu G,Wang B,Liu Y,Zhang L,Jing T,Tang M,Xu X,Jiao K,Xiang L,Fu Y,Tang D,Zhang X,Jin W,Zhuang G,Zhao X,Liu Y
11-0112-82 was used in Flow Cytometry to show that the deubiquitinase USP12 is commonly downregulated in the KrasG12D-driven mouse lung tumour and human non-small cell lung cancer owing to the activation of AKT-mTOR signalling.
Wed Aug 11 00:00:00 EDT 2021
Sequential Treatment of Bioresponsive Nanoparticles Elicits Antiangiogenesis and Apoptosis and Synergizes with a CD40 Agonist for Antitumor Immunity.
ACS nano
Ling X,Jiang X,Li Y,Han W,Rodriguez M,Xu Z,Lin W
11-0112-82 was used in flow cytometry to sequential delivery of antiangiogenic and chemotherapeutic agents with bioresponsive NPs activates tumor microenvironments and synergizes with CD40 agonist to regress transplanted tumors and inhibit disseminated tumors in a lung cancer mouse model.
Tue Jan 26 00:00:00 EST 2021
Encapsulation of murine hematopoietic stem and progenitor cells in a thiol-crosslinked maleimide-functionalized gelatin hydrogel.
Acta biomaterialia
Gilchrist AE,Serrano JF,Ngo MT,Hrnjak Z,Kim S,Harley BAC
11-0112-82 was used in flow cytometry to report inclusion of a peptide crosslinker that can be cleaved via the proteolytic action of Sortase A and show that Sortase A exposure does not degrade sensitive surface marker expression patterns.
Wed Sep 01 00:00:00 EDT 2021
Treatment With the CSF1R Antagonist GW2580, Sensitizes Microglia to Reactive Oxygen Species.
Frontiers in immunology
Soto-Diaz K,Vailati-Riboni M,Louie AY,McKim DB,Gaskins HR,Johnson RW,Steelman AJ
11-0112-82 was used in Flow cytometry/Cell sorting to suggest that partial CSF1R antagonism may render microglia more susceptible to reactive oxygen and nitrogen species.
Mon Feb 07 00:00:00 EST 2022
Increasing cytosolic Ca2+ levels restore cell proliferation and stem cell potency in aged MSCs.
Stem cell research
Ahamad N,Sun Y,Singh BB
11-0112-82 was used in Cell Culture to suggest that Ca2+ entry is essential for preventing the loss of aged stem cell function and supplementing Ca2+ not only restored their proliferative potential but, allowed them to develop into younger stem cell lineages that could be critical for regenerative medicine.
Fri Oct 01 00:00:00 EDT 2021
Hydrogels Containing Gradients in Vascular Density Reveal Dose-Dependent Role of Angiocrine Cues on Stem Cell Behavior.
Advanced functional materials
Ngo MT,Barnhouse VR,Gilchrist AE,Mahadik BP,Hunter CJ,Hensold JN,Petrikas N,Harley BAC
11-0112-82 was used in Flow cytometry/Cell sorting to report the successful development of a microfluidic device to generate hydrogels containing lateral gradients in vascular density as a means to identify angiocrine signals underlying hematopoietic stem cell culture ex vivo.
Thu Dec 16 00:00:00 EST 2021
Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP.
Immunity
Zhou Y,Fei M,Zhang G,Liang WC,Lin W,Wu Y,Piskol R,Ridgway J,McNamara E,Huang H,Zhang J,Oh J,Patel JM,Jakubiak D,Lau J,Blackwood B,Bravo DD,Shi Y,Wang J,Hu HM,Lee WP,Jesudason R,Sangaraju D,Modrusan Z,Anderson KR,Warming S,Roose-Girma M,Yan M
11-0112-82 was used in Immunohistochemistry,Flow Cytometry to examine the effect of blocking apoptotic cell clearance on anti-tumor immune response.
Tue Feb 18 00:00:00 EST 2020
Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP.
Immunity
Zhou Y,Fei M,Zhang G,Liang WC,Lin W,Wu Y,Piskol R,Ridgway J,McNamara E,Huang H,Zhang J,Oh J,Patel JM,Jakubiak D,Lau J,Blackwood B,Bravo DD,Shi Y,Wang J,Hu HM,Lee WP,Jesudason R,Sangaraju D,Modrusan Z,Anderson KR,Warming S,Roose-Girma M,Yan M
11-0112-82 was used in Immunohistochemistry,Flow Cytometry to examine the effect of blocking apoptotic cell clearance on anti-tumor immune response.
Tue Feb 18 00:00:00 EST 2020
Regulatory T Cell-Derived TGF-β1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity.
Immunity
Turner JA,Stephen-Victor E,Wang S,Rivas MN,Abdel-Gadir A,Harb H,Cui Y,Fanny M,Charbonnier LM,Fong JJH,Benamar M,Wang L,Burton OT,Bansal K,Bry L,Zhu C,Li QZ,Clement RL,Oettgen HC,Crestani E,Rachid R,Sage PT,Chatila TA
11-0112-82 was used in Flow Cytometry to show that Treg cells in food allergy (FA) had decreased expression of transforming growth factor beta 1 (TGF-β1) because of interleukin-4 (IL-4)- and signal transducer and activator of transciription-6 (STAT6)-dependent inhibition of Tgfb1 transcription.
Tue Dec 15 00:00:00 EST 2020
In Situ Maturation and Tissue Adaptation of Type 2 Innate Lymphoid Cell Progenitors.
Immunity
Zeis P,Lian M,Fan X,Herman JS,Hernandez DC,Gentek R,Elias S,Symowski C,Knöpper K,Peltokangas N,Friedrich C,Doucet-Ladeveze R,Kabat AM,Locksley RM,Voehringer D,Bajenoff M,Rudensky AY,Romagnani C,Grün D,Gasteiger G
11-0112-82 was used in Flow Cytometry to identify local ILCPs and reveal ILCP in situ differentiation and tissue adaptation as a mechanism of ILC maintenance and phenotypic diversification.
Tue Oct 13 00:00:00 EDT 2020
Emergence of a High-Plasticity Cell State during Lung Cancer Evolution.
Cancer cell
Marjanovic ND,Hofree M,Chan JE,Canner D,Wu K,Trakala M,Hartmann GG,Smith OC,Kim JY,Evans KV,Hudson A,Ashenberg O,Porter CBM,Bejnood A,Subramanian A,Pitter K,Yan Y,Delorey T,Phillips DR,Shah N,Chaudhary O,Tsankov A,Hollmann T,Rekhtman N,Massion PP,Poirier JT,Mazutis L,Li R,Lee JH,Amon A,Rudin CM,Jacks T,Regev A,Tammela T
11-0112-82 was used in Flow Cytometry to profile cellular transcriptomes of lung tumours at different stages.
Mon Aug 10 00:00:00 EDT 2020
SRC-3 Functions as a Coactivator of T-bet by Regulating the Maturation and Antitumor Activity of Natural Killer Cells.
Cancer immunology research
Hu M,Lu Y,Qi Y,Zhang Z,Wang S,Xu Y,Chen F,Tang Y,Chen S,Chen M,Du C,Shen M,Wang F,Su Y,Deng Y,Wang J
11-0112-82 was used in Flow Cytometry to study the role of SRC-3 as a coactivator of T-bet in natural killer-cell biology and indicate that targeting SRC-3 may be a promising strategy to increase the tumor surveillance function of natural killer cells.
Tue Sep 01 00:00:00 EDT 2020
Characterization and regulation of osteoclast precursors following chronic Porphyromonas gingivalis infection.
Journal of leukocyte biology
Zhao Y,Li Z,Su L,Ballesteros-Tato A,Katz J,Michalek SM,Feng X,Zhang P
11-0112-82 was used in Flow Cytometry to provide new insights into the characterization and regulation of OCP following a chronic bacterial infection.
Thu Oct 01 00:00:00 EDT 2020
Development of an inexpensive Raman-compatible substrate for the construction of a microarray screening platform.
The Analyst
Pastrana-Otero I,Majumdar S,Gilchrist AE,Gorman BL,Harley BAC,Kraft ML
11-0112-82 was used in Flow Cytometry to show that the spectra acquired from individual living cells on functionalized PA gels attached to our custom substrates were of sufficient quality to enable accurate identification of cell phenotypes using PLS-DA models of the cell spectra.
Mon Oct 26 00:00:00 EDT 2020
Connecting secretome to hematopoietic stem cell phenotype shifts in an engineered bone marrow niche.
Integrative biology : quantitative biosciences from nano to macro
Gilchrist AE,Harley BAC
11-0112-82 was used in Flow Cytometry to investigate the mechanism of how marrow-derived mesenchymal stromal and progenitor cells impacts hematopoietic stem cells fate decisions.
Fri Jul 10 00:00:00 EDT 2020
Macrophage NCOR1 Deficiency Ameliorates Myocardial Infarction and Neointimal Hyperplasia in Mice.
Journal of the American Heart Association
Du LJ,Sun JY,Zhang WC,Wang YL,Zhu H,Liu T,Gao MZ,Zheng C,Zhang YY,Liu Y,Liu Y,Shao S,Zhang XQ,Leng Q,Auwerx J,Duan SZ
11-0112-82 was used in Flow Cytometry to demonstrate that NCOR1 is a critical regulator of macrophage inflammation and proliferation and that deficiency of NCOR1 in macrophages attenuates MI and neointimal hyperplasia.
Tue Aug 04 00:00:00 EDT 2020
Meningeal lymphatics clear erythrocytes that arise from subarachnoid hemorrhage.
Nature communications
Chen J,Wang L,Xu H,Xing L,Zhuang Z,Zheng Y,Li X,Wang C,Chen S,Guo Z,Liang Q,Wang Y
11-0112-82 was used in Flow cytometry/Cell sorting to demonstrate that the meningeal lymphatics drain extravasated erythrocytes from CSF into CLNs after SAH, while suggesting that modulating this draining may offer therapeutic approaches to alleviate SAH severity.
Mon Jun 22 00:00:00 EDT 2020
A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling.
Cell reports
Donado CA,Cao AB,Simmons DP,Croker BA,Brennan PJ,Brenner MB
11-0112-82 was used in Flow Cytometry to describe an alternative, two-cell model for IL-1β release where invariant natural killer T (iNKT) cells use the death receptor pathway to instruct antigen-presenting cells to secrete IL-1β.
Tue Apr 07 00:00:00 EDT 2020
Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models.
Communications biology
Waaler J,Mygland L,Tveita A,Strand MF,Solberg NT,Olsen PA,Aizenshtadt A,Fauskanger M,Lund K,Brinch SA,Lycke M,Dybing E,Nygaard V,Bøe SL,Heintz KM,Hovig E,Hammarström C,Corthay A,Krauss S
11-0112-82 was used in Flow Cytometry to show that a specific small-molecule tankyrase inhibitor, G007-LK, decreases WNT/β-catenin and YAP signaling in the syngeneic murine B16-F10 and Clone M-3 melanoma models and sensitizes the tumors to anti-PD-1 immune checkpoint therapy.
Fri Apr 24 00:00:00 EDT 2020
A Regulatory Circuit Controlling the Dynamics of NFκB cRel Transitions B Cells from Proliferation to Plasma Cell Differentiation.
Immunity
Roy K,Mitchell S,Liu Y,Ohta S,Lin YS,Metzig MO,Nutt SL,Hoffmann A
11-0112-82 was used in Flow Cytometry to provide a mechanistic explanation of how dysregulation of this bi-stable circuit might result in pathologic B cell population phenotypes and thus offer new avenues for diagnostic stratification and treatment.
Tue Mar 19 00:00:00 EDT 2019
TNF-α Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration.
Cell stem cell
Yamashita M,Passegué E
11-0112-82 was used in Flow Cytometry to reveal several TNF-α-mediated pro-survival mechanisms unique to HSCs, highlight an important role for necroptosis in HSC killing, and establish TNF-α as a major pro-survival and pro-regeneration factor for HSCs.
Thu Sep 05 00:00:00 EDT 2019
Oral ferroportin inhibitor ameliorates ineffective erythropoiesis in a model of β-thalassemia.
The Journal of clinical investigation
Manolova V,Nyffenegger N,Flace A,Altermatt P,Varol A,Doucerain C,Sundstrom H,Dürrenberger F
11-0112-82 was used in Flow Cytometry to identified oral ferroportin inhibitors by screening a library of small molecular weight compounds for modulators of ferroportin internalization.
Mon Dec 09 00:00:00 EST 2019
Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis.
The Journal of experimental medicine
Li S,Wu Y,Yang D,Wu C,Ma C,Liu X,Moynagh PN,Wang B,Hu G,Yang S
11-0112-82 was used in Immunohistochemistry, Flow Cytometry to further define the role of gasdermin D in experimental autoimmune encephalomyelitis.
Mon Nov 04 00:00:00 EST 2019
Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis.
The Journal of experimental medicine
Li S,Wu Y,Yang D,Wu C,Ma C,Liu X,Moynagh PN,Wang B,Hu G,Yang S
11-0112-82 was used in Immunohistochemistry, Flow Cytometry to further define the role of gasdermin D in experimental autoimmune encephalomyelitis.
Mon Nov 04 00:00:00 EST 2019
Low-Dose Apatinib Optimizes Tumor Microenvironment and Potentiates Antitumor Effect of PD-1/PD-L1 Blockade in Lung Cancer.
Cancer immunology research
Zhao S,Ren S,Jiang T,Zhu B,Li X,Zhao C,Jia Y,Shi J,Zhang L,Liu X,Qiao M,Chen X,Su C,Yu H,Zhou C,Zhang J,Camidge DR,Hirsch FR
11-0112-82 was used in Flow Cytometry to analyze the impact of apatinib, a smallmolecule VEGFR2-TKI, on the TME in murine Lewis lung carcinoma (LLC) models at different doses alone and in combination with an anti–PD-L1.
Mon Apr 01 00:00:00 EDT 2019
Inactivation of endothelial adenosine A2A receptors protects mice from cerebral ischaemia-induced brain injury.
British journal of pharmacology
Zhou Y,Zeng X,Li G,Yang Q,Xu J,Zhang M,Mao X,Cao Y,Wang L,Xu Y,Wang Y,Zhang Y,Xu Z,Wu C,Chen JF,Hoda MN,Liu Z,Hong M,Huo Y
11-0112-82 was used in Flow Cytometry to help open new approaches to vascular protection after ischaemic stroke.
Mon Jul 01 00:00:00 EDT 2019
Neural anti-inflammatory action mediated by two types of acetylcholine receptors in the small intestine.
Scientific reports
Kimura H,Imura YK,Tomiyasu H,Mihara T,Kaji N,Ohno K,Unno T,Tanahashi Y,Jan TR,Tsubone H,Ozaki H,Hori M
11-0112 was used in Flow cytometry/Cell sorting to clarify the anti-inflammatory mechanism underlying the serotonin-4 receptor agonist, mosapride citrate-induced anti-inflammatory action on postoperative ileus.
Wed Apr 10 00:00:00 EDT 2019
Targeting a therapeutic LIF transgene to muscle via the immune system ameliorates muscular dystrophy.
Nature communications
Welc SS,Flores I,Wehling-Henricks M,Ramos J,Wang Y,Bertoni C,Tidball JG
11-0112 was used in Flow cytometry/Cell sorting to study the effect of expression of a therapeutic transgene in leukocyte progenitors that invade muscle on selective and timely delivery to diseased muscle.
Wed Jun 26 00:00:00 EDT 2019
Toll-Like Receptor 7 Agonist-Induced Dermatitis Causes Severe Dextran Sulfate Sodium Colitis by Altering the Gut Microbiome and Immune Cells.
Cellular and molecular gastroenterology and hepatology
Kiyohara H,Sujino T,Teratani T,Miyamoto K,Arai MM,Nomura E,Harada Y,Aoki R,Koda Y,Mikami Y,Mizuno S,Naganuma M,Hisamatsu T,Kanai T
11-0112 was used in Flow cytometry/Cell sorting to show that skin inflammation may contribute to pathogenic conditions in the gut via immunologic and microbiological changes.
Mon Apr 29 00:00:00 EDT 2019
Large-Scale Clonal Analysis Resolves Aging of the Mouse Hematopoietic Stem Cell Compartment.
Cell stem cell
Yamamoto R,Wilkinson AC,Ooehara J,Lan X,Lai CY,Nakauchi Y,Pritchard JK,Nakauchi H
11-0112 was used in Flow cytometry/Cell sorting to determine the age-related functional changes to the haematopoietic stem cell compartment.
Thu Apr 05 00:00:00 EDT 2018
Nongenetic origins of cell-to-cell variability in B lymphocyte proliferation.
Proceedings of the National Academy of Sciences of the United States of America
Mitchell S,Roy K,Zangle TA,Hoffmann A
11-0112 was used in Flow cytometry/Cell sorting to characterise the role of molecular noise in determining phenotype heterogeneity.
Tue Mar 20 00:00:00 EDT 2018
Lenalidomide and Programmed Death-1 Blockade Synergistically Enhances the Effects of Dendritic Cell Vaccination in a Model of Murine Myeloma.
Frontiers in immunology
Vo MC,Jung SH,Chu TH,Lee HJ,Lakshmi TJ,Park HS,Kim HJ,Rhee JH,Lee JJ
11-0112 was used in Flow cytometry/Cell sorting to investigate the efficacy of dendritic cell vaccination in combination with lenalidomide and PD-1 blockade in a model of murine myeloma.
Sun Jan 03 00:00:00 EST 2021
Type 2 Innate Lymphocytes Actuate Immunity Against Tumours and Limit Cancer Metastasis.
Scientific reports
Saranchova I,Han J,Zaman R,Arora H,Huang H,Fenninger F,Choi KB,Munro L,Pfeifer CG,Welch I,Takei F,Jefferies WA
11-0112 was used in Flow cytometry/Cell sorting to study the role of type 2 innate lymphoid cells in enhancing anti-cancer immunity and controlling metastasis.
Tue Feb 13 00:00:00 EST 2018
POH1 deubiquitinates pro-interleukin-1β and restricts inflammasome activity.
Nature communications
Zhang L,Liu Y,Wang B,Xu G,Yang Z,Tang M,Ma A,Jing T,Xu X,Zhang X,Liu Y
11-0112 was used in Flow cytometry/Cell sorting to show that the deubiquitinase POH1 negatively regulates the immune response triggered by inflammasome activation.
Fri Oct 12 00:00:00 EDT 2018
Depletion of tumor-associated macrophages switches the epigenetic profile of pancreatic cancer infiltrating T cells and restores their anti-tumor phenotype.
Oncoimmunology
Borgoni S,Iannello A,Cutrupi S,Allavena P,D'Incalci M,Novelli F,Cappello P
11-0112 was used in Flow cytometry/Cell sorting to analyse whether the functional and epigenetic profile of T cells that infiltrate pancreatic ductal adenocarcinoma is modulated by the microenvironment, and in particular by tumour-associated macrophages.
Tue Jan 12 00:00:00 EST 2021
Intravenous Labeling and Analysis of the Content of Thymic Perivascular Spaces.
Bio-protocol
Ruscher R,Hogquist KA
11-0112 was used in Flow cytometry/Cell sorting to investigate hematopoietic cell subsets within the perivascular spaces of the thymus.
Mon Mar 05 00:00:00 EST 2018
Non-coding Transcription Instructs Chromatin Folding and Compartmentalization to Dictate Enhancer-Promoter Communication and T Cell Fate.
Cell
Isoda T,Moore AJ,He Z,Chandra V,Aida M,Denholtz M,Piet van Hamburg J,Fisch KM,Chang AN,Fahl SP,Wiest DL,Murre C
11-0112 was used in Flow cytometry/Cell sorting to study the repositioning of the Bcl11b enhancer to dictate the fate of developing T cells.
Thu Sep 21 00:00:00 EDT 2017
TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease.
Cell
Ulland TK,Song WM,Huang SC,Ulrich JD,Sergushichev A,Beatty WL,Loboda AA,Zhou Y,Cairns NJ,Kambal A,Loginicheva E,Gilfillan S,Cella M,Virgin HW,Unanue ER,Wang Y,Artyomov MN,Holtzman DM,Colonna M
11-0112 was used in Flow cytometry/Cell sorting to demonstrate that TREM2 enables microglial responses during Alzheimer's disease by sustaining cellular energetic and biosynthetic metabolism.
Thu Aug 10 00:00:00 EDT 2017
T-Cell Mineralocorticoid Receptor Controls Blood Pressure by Regulating Interferon-Gamma.
Circulation research
Sun XN,Li C,Liu Y,Du LJ,Zeng MR,Zheng XJ,Zhang WC,Liu Y,Zhu M,Kong D,Zhou L,Lu L,Shen ZX,Yi Y,Du L,Qin M,Liu X,Hua Z,Sun S,Yin H,Zhou B,Yu Y,Zhang Z,Duan SZ
11-0112 was used in Flow cytometry/Cell sorting to determine the role of T-cell mineralocorticoid receptor in blood pressure regulation and explore the mechanism.
Fri May 12 00:00:00 EDT 2017
Macrophage-derived IL-10 mediates mucosal repair by epithelial WISP-1 signaling.
The Journal of clinical investigation
Quiros M,Nishio H,Neumann PA,Siuda D,Brazil JC,Azcutia V,Hilgarth R,O'Leary MN,Garcia-Hernandez V,Leoni G,Feng M,Bernal G,Williams H,Dedhia PH,Gerner-Smidt C,Spence J,Parkos CA,Denning TL,Nusrat A
11-0112 was used in Flow cytometry/Cell sorting to investigate the mechanisms involved in crosstalk between immune cells and the epithelium in mucosal barrier repair.
Fri Sep 01 00:00:00 EDT 2017
DC subset-specific induction of T cell responses upon antigen uptake via Fcγ receptors in vivo.
The Journal of experimental medicine
Lehmann CHK,Baranska A,Heidkamp GF,Heger L,Neubert K,Lühr JJ,Hoffmann A,Reimer KC,Brückner C,Beck S,Seeling M,Kießling M,Soulat D,Krug AB,Ravetch JV,Leusen JHW,Nimmerjahn F,Dudziak D
11-0112 was used in Flow cytometry/Cell sorting to suggest that targeting antigens to FcγRs on DCs may be a promising approach to raise immunogenic or tolerogenic T cell responses to antigens of choice.
Mon May 01 00:00:00 EDT 2017
Double-stranded RNA promotes CTL-independent tumor cytolysis mediated by CD11b+Ly6G+ intratumor myeloid cells through the TICAM-1 signaling pathway.
Cell death and differentiation
Shime H,Matsumoto M,Seya T
11-0112 was used in Flow cytometry/Cell sorting to study the response of CD11b+Ly6G+ granulocytic myeloid-derived suppressor cells to polyI:C in an EL4 tumour implant model.
Wed Mar 01 00:00:00 EST 2017
IL33-mediated ILC2 activation and neutrophil IL5 production in the lung response after severe trauma: A reverse translation study from a human cohort to a mouse trauma model.
PLoS medicine
Xu J,Guardado J,Hoffman R,Xu H,Namas R,Vodovotz Y,Xu L,Ramadan M,Brown J,Turnquist HR,Billiar TR
11-0112 was used in Flow cytometry/Cell sorting to suggest that IL33 may initiate early detrimental type 2 immune responses after trauma through ILC2 regulation of neutrophil IL5 production.
Sat Jul 01 00:00:00 EDT 2017
Prolonged Deleterious Influences of Chemotherapeutic Agent CPT-11 on Resident Peritoneal Macrophages and B1 Cells.
Frontiers in immunology
Bai WJ,Li CG,Zhang CC,Xu LH,Zeng QZ,Hu B,Hong Z,He XH,Ouyang DY
11-0112 was used in Flow cytometry/Cell sorting to characterise the immune recovery processes of various innate immune cells in the intestine following CPT-11 treatment.
Wed Nov 20 00:00:00 EST 2019
Peripheral administration of the soluble TNF inhibitor XPro1595 modifies brain immune cell profiles, decreases beta-amyloid plaque load, and rescues impaired long-term potentiation in 5xFAD mice.
Neurobiology of disease
MacPherson KP,Sompol P,Kannarkat GT,Chang J,Sniffen L,Wildner ME,Norris CM,Tansey MG
11-0112 was used in Flow cytometry/Cell sorting to assess the translational potential of soluble TNF inhibitors to modulate brain immune cell infiltration, dampen neuroinflammation and prevent or delay neuronal dysfunction in Alzheimer's disease.
Thu Jun 01 00:00:00 EDT 2017
Distribution and differentiation of myeloid-derived suppressor cells after fluid resuscitation in mice with hemorrhagic shock.
Journal of Zhejiang University. Science. B
Jiang JK,Fang W,Hong LJ,Lu YQ
11-0112 was used in Flow cytometry/Cell sorting to investigate the distribution and differentiation of myeloid-derived suppressor cells in hemorrhagic shock mice, which are resuscitated with various fluids.
Tue Jul 11 00:00:00 EDT 2017
Lung Epithelial Cell-Derived Microvesicles Regulate Macrophage Migration via MicroRNA-17/221-Induced Integrin β1 Recycling.
Journal of immunology (Baltimore, Md. : 1950)
Lee H,Zhang D,Wu J,Otterbein LE,Jin Y
11-0112 was used in Flow cytometry/Cell sorting to explore the mechanisms by which acid exposure initiates macrophage recruitment and migration during development of acute lung injury.
Tue Aug 15 00:00:00 EDT 2017
Impaired phagocytosis of apoptotic cells causes accumulation of bone marrow-derived macrophages in aged mice.
BMB reports
Kim OH,Kim H,Kang J,Yang D,Kang YH,Lee DH,Cheon GJ,Park SC,Oh BC
11-0112 was used in Flow cytometry/Cell sorting to identify age-dependent macrophage accumulation in the bone marrow, showing that ageing significantly increases the number of M1 macrophages and impairs polarisation of BMDMs.
Sun Jan 01 00:00:00 EST 2017
Mouse IP-10 Gene Delivered by Folate-modified Chitosan Nanoparticles and Dendritic/tumor Cells Fusion Vaccine Effectively Inhibit the Growth of Hepatocellular Carcinoma in Mice.
Theranostics
Hu Z,Chen J,Zhou S,Yang N,Duan S,Zhang Z,Su J,He J,Zhang Z,Lu X,Zhao Y
11-0112 was used in Flow cytometry/Cell sorting to illustrate that the mIP-10 enhances the anti-tumor effect of DC/tumor cell fusion vaccine by alleviating the immunosuppressive tumor environment.
Mon Mar 19 00:00:00 EDT 2018
Small molecule p300/catenin antagonist enhances hematopoietic recovery after radiation.
PloS one
Zhao Y,Wu K,Nguyen C,Smbatyan G,Melendez E,Higuchi Y,Chen Y,Kahn M
11-0112 was used in Flow cytometry/Cell sorting to report that the small molecule YH250 stimulates hematopoiesis in lethally or sublethally irradiated mice.
Tue Sep 26 00:00:00 EDT 2017
Understanding CD8+ T-cell responses toward the native and alternate HLA-A*02:01-restricted WT1 epitope.
Clinical & translational immunology
Nguyen TH,Tan AC,Xiang SD,Goubier A,Harland KL,Clemens EB,Plebanski M,Kedzierska K
11-0112-82 was used in Flow cytometry/Cell sorting to investigate HLA in Wilms' tumour 1 antigen.
Wed Mar 01 00:00:00 EST 2017
Understanding CD8+ T-cell responses toward the native and alternate HLA-A*02:01-restricted WT1 epitope.
Clinical & translational immunology
Nguyen TH,Tan AC,Xiang SD,Goubier A,Harland KL,Clemens EB,Plebanski M,Kedzierska K
11-0112-82 was used in Flow cytometry/Cell sorting to investigate HLA in Wilms' tumour 1 antigen.
Wed Mar 01 00:00:00 EST 2017
Ebola Virus Glycoprotein Induces an Innate Immune Response In vivo via TLR4.
Frontiers in microbiology
Lai CY,Strange DP,Wong TAS,Lehrer AT,Verma S
11-0112 was used in Flow cytometry/Cell sorting to investigate the early immune response to purified Ebola virus glycoprotein alone in vitro and in vivo.
Tue Sep 29 00:00:00 EDT 2020
Microgrooved-surface topography enhances cellular division and proliferation of mouse bone marrow-derived mesenchymal stem cells.
PloS one
Chaudhary JK,Rath PC
11-0112 was used in Flow cytometry/Cell sorting to assess the benefits of studying mesenchymal stem cell populations in a microgrooved surface-culture compared to standard culture flask-grown cells.
Thu Oct 19 00:00:00 EDT 2017
Inositol polyphosphate multikinase promotes Toll-like receptor-induced inflammation by stabilizing TRAF6.
Science advances
Kim E,Beon J,Lee S,Park SJ,Ahn H,Kim MG,Park JE,Kim W,Yuk JM,Kang SJ,Lee SH,Jo EK,Seong RH,Kim S
11-0112 was used in Flow cytometry/Cell sorting to investigate how TRAF6 protein stability is controlled in TLR signalling, showing that Inositol polyphosphate multikinase stabilises TRAF6 and promotes TLR-induced inflammation.
Sat Apr 01 00:00:00 EDT 2017
The cryo-thermal therapy eradicated melanoma in mice by eliciting CD4+ T-cell-mediated antitumor memory immune response.
Cell death & disease
He K,Liu P,Xu LX
11-0112 was used in Flow cytometry/Cell sorting to demonstrate the therapeutic efficacy in other aggressive tumor models and further investigate the mechanism of long-term survival induced.
Thu Mar 23 00:00:00 EDT 2017
Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal.
Nature cell biology
Pietras EM,Mirantes-Barbeito C,Fong S,Loeffler D,Kovtonyuk LV,Zhang S,Lakshminarasimhan R,Chin CP,Techner JM,Will B,Nerlov C,Steidl U,Manz MG,Schroeder T,Passegué E
11-0112 was used in Flow cytometry/Cell sorting to identify a critical regulatory circuit that tailors HSC responses to acute needs, and is likely to underlie deregulated blood homeostasis in chronic inflammation conditions.
Wed Jun 01 00:00:00 EDT 2016
Vagus nerve stimulation mediates protection from kidney ischemia-reperfusion injury through α7nAChR+ splenocytes.
The Journal of clinical investigation
Inoue T,Abe C,Sung SS,Moscalu S,Jankowski J,Huang L,Ye H,Rosin DL,Guyenet PG,Okusa MD
11-0112 was used in Flow cytometry/Cell sorting to demonstrate that vagus nerve stimulation-mediated attenuation of attenuated acute kidney injury and systemic inflammation depends on α7nAChR-positive splenocytes.
Mon May 02 00:00:00 EDT 2016
Autophagy induced by AXL receptor tyrosine kinase alleviates acute liver injury via inhibition of NLRP3 inflammasome activation in mice.
Autophagy
Han J,Bae J,Choi CY,Choi SP,Kang HS,Jo EK,Park J,Lee YS,Moon HS,Park CG,Lee MS,Chun T
11-0112 was used in Flow cytometry/Cell sorting to demonstrate that GAS6-AXL signaling-mediated autophagy induction in murine macrophages ameliorates hepatic inflammatory responses by inhibiting NLRP3 inflammasome activation.
Thu Dec 01 00:00:00 EST 2016
Mesenchymal stromal cell-derived extracellular vesicles rescue radiation damage to murine marrow hematopoietic cells.
Leukemia
Wen S,Dooner M,Cheng Y,Papa E,Del Tatto M,Pereira M,Deng Y,Goldberg L,Aliotta J,Chatterjee D,Stewart C,Carpanetto A,Collino F,Bruno S,Camussi G,Quesenberry P
11-0112 was used in Flow cytometry/Cell sorting to evaluate the capacity of mesenchymal stromal cell-derived extracellular vesicles to rescue murine marrow hematopoietic cells damage following exposure to radiation, showing that damage could be reversed using both murine and human MSC-EVs.
Tue Nov 01 00:00:00 EDT 2016
MicroRNA-155 Promotes the Directional Migration of Resident Smooth Muscle Progenitor Cells by Regulating Monocyte Chemoattractant Protein 1 in Transplant Arteriosclerosis.
Arteriosclerosis, thrombosis, and vascular biology
Sun Y,Wang K,Ye P,Wu J,Ren L,Zhang A,Huang X,Deng P,Wu C,Yue Z,Chen Z,Ding X,Chen J,Xia J
11-0112 was used in Flow cytometry/Cell sorting to investigate the origin of smooth muscle-like cells in transplant arteriosclerosis lesions, the mechanisms responsible for their accumulation in the neointima, and the factors that drive these processes.
Wed Jun 01 00:00:00 EDT 2016
G-CSF-Induced Suppressor IL-10+ Neutrophils Promote Regulatory T Cells That Inhibit Graft-Versus-Host Disease in a Long-Lasting and Specific Way.
Journal of immunology (Baltimore, Md. : 1950)
Perobelli SM,Mercadante AC,Galvani RG,Gonçalves-Silva T,Alves AP,Pereira-Neves A,Benchimol M,Nóbrega A,Bonomo A
11-0112 was used in Flow cytometry/Cell sorting to study the role of incoming IL-10+ neutrophils from G-CSF-treated donor spleen in inhibiting acute graft-versus-host disease.
Tue Nov 01 00:00:00 EDT 2016
Effects of ketanserin on experimental colitis in mice and macrophage function.
International journal of molecular medicine
Xiao J,Shao L,Shen J,Jiang W,Feng Y,Zheng P,Liu F
11-0112 was used in Flow cytometry/Cell sorting to study the effects of ketanserin on experimental colitis in mice and macrophage function.
Tue Mar 01 00:00:00 EST 2016
Immunosuppression, peripheral inflammation and invasive infection from endogenous gut microbiota activate retinal microglia in mouse models.
Microbiology and immunology
Maneu V,Noailles A,Gómez-Vicente V,Carpena N,Cuenca N,Gil ML,Gozalbo D
11-0112 was used in Flow cytometry/Cell sorting to determine whether non-ocular conditions could lead to the activation of retinal microglia.
Thu Sep 01 00:00:00 EDT 2016
Kappa opioid receptor activation alleviates experimental autoimmune encephalomyelitis and promotes oligodendrocyte-mediated remyelination.
Nature communications
Du C,Duan Y,Wei W,Cai Y,Chai H,Lv J,Du X,Zhu J,Xie X
11-0112 was used in Flow cytometry/Cell sorting to show that kappa opioid receptor activation alleviates autoimmune encephalomyelitis and promotes remyelination..
Mon Apr 04 00:00:00 EDT 2016
Erythropoietin treatment in murine multiple myeloma: immune gain and bone loss.
Scientific reports
Deshet-Unger N,Hiram-Bab S,Haim-Ohana Y,Mittelman M,Gabet Y,Neumann D
11-0112 was used in Flow cytometry/Cell sorting to reveal that in multiple myeloma, erythropoietin may act as a double-edged sword by stimulating the immune response whilst accelerating bone resorption.
Tue Aug 02 00:00:00 EDT 2016
miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia.
Nature communications
Jiang X,Hu C,Arnovitz S,Bugno J,Yu M,Zuo Z,Chen P,Huang H,Ulrich B,Gurbuxani S,Weng H,Strong J,Wang Y,Li Y,Salat J,Li S,Elkahloun AG,Yang Y,Neilly MB,Larson RA,Le Beau MM,Herold T,Bohlander SK,Liu PP,Zhang J,Li Z,He C,Jin J,Hong S,Chen J
11-0112 was used in Flow cytometry/Cell sorting to investigate the anti-tumourigenic role of miR-22, showing that it has an anti-tumour role in acute myeloid leukaemia.
Tue Apr 26 00:00:00 EDT 2016
Peripheral Leukocyte Migration in Ferrets in Response to Infection with Seasonal Influenza Virus.
PloS one
Music N,Reber AJ,Kim JH,York IA
11-0112 was used in Flow cytometry/Cell sorting to show that lymphocytes differentially home to lymph nodes and tissues based on cell type and proximity to the site of infection.
Wed Jul 12 00:00:00 EDT 2017
BubR1 Insufficiency Results in Decreased Macrophage Proliferation and Attenuated Atherogenesis in Apolipoprotein E-Deficient Mice.
Journal of the American Heart Association
Tanaka S,Matsumoto T,Matsubara Y,Harada Y,Kyuragi R,Koga JI,Egashira K,Nakashima Y,Yonemitsu Y,Maehara Y
11-0112 was used in Flow cytometry/Cell sorting to investigate the effects of BubR1 on atherosclerosis.
Sat Sep 24 00:00:00 EDT 2016
Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke.
Nature communications
Szalay G,Martinecz B,Lénárt N,Környei Z,Orsolits B,Judák L,Császár E,Fekete R,West BL,Katona G,Rózsa B,Dénes Á
11-0112 was used in Flow cytometry/Cell sorting to investigate the influence of microglia on neuronal activity and survival in the injured brain in vivo.
Tue May 03 00:00:00 EDT 2016
Dendritic cell-derived nitric oxide inhibits the differentiation of effector dendritic cells.
Oncotarget
Si C,Zhang R,Wu T,Lu G,Hu Y,Zhang H,Xu F,Wei P,Chen K,Tang H,Yeretssian G,Xiong H
11-0112 was used in Flow cytometry/Cell sorting to demonstrate that DC-derived nitric oxide restrains effector DC development to treat autoimmune and inflammatory diseases.
Tue Nov 15 00:00:00 EST 2016
Perivascular Mast Cells Govern Shear Stress-Induced Arteriogenesis by Orchestrating Leukocyte Function.
Cell reports
Chillo O,Kleinert EC,Lautz T,Lasch M,Pagel JI,Heun Y,Troidl K,Fischer S,Caballero-Martinez A,Mauer A,Kurz ARM,Assmann G,Rehberg M,Kanse SM,Nieswandt B,Walzog B,Reichel CA,Mannell H,Preissner KT,Deindl E
11-0112 was used in Flow cytometry/Cell sorting to find that perivascular mast cells are central regulators of shear stress-induced arteriogenesis by orchestrating leukocyte function and growth factor/cytokine release.
Tue Aug 23 00:00:00 EDT 2016
Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma.
Journal for immunotherapy of cancer
Patel MA,Kim JE,Theodros D,Tam A,Velarde E,Kochel CM,Francica B,Nirschl TR,Ghasemzadeh A,Mathios D,Harris-Bookman S,Jackson CC,Jackson C,Ye X,Tran PT,Tyler B,Coric V,Selby M,Brem H,Drake CG,Pardoll DM,Lim M
11-0112 was used in Flow cytometry/Cell sorting to provide preclinical evidence for the use of anti-GITR (1) non-depleting antibodies in combination with SRS in GBM.
Wed May 18 00:00:00 EDT 2016
Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt.
Nature medicine
Wilson JE,Petrucelli AS,Chen L,Koblansky AA,Truax AD,Oyama Y,Rogers AB,Brickey WJ,Wang Y,Schneider M,Mühlbauer M,Chou WC,Barker BR,Jobin C,Allbritton NL,Ramsden DA,Davis BK,Ting JP
11-0112 was used in Flow cytometry/Cell sorting to show AIM2 regulates colon tumorigenesis by reducing activation of both DNA-PK and Akt, suggesting that Akt inhibitors could be used in treatment of certain cancers.
Sat Aug 01 00:00:00 EDT 2015
Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy.
Nature biotechnology
Kim J,Li WA,Choi Y,Lewin SA,Verbeke CS,Dranoff G,Mooney DJ
11-0112 was used in Flow cytometry/Cell sorting to demonstrate that injected mesoporous silica rods assemble in vivo to form structures providing a 3D cellular microenvironment for host immune cells.
Thu Jan 01 00:00:00 EST 2015
High salt primes a specific activation state of macrophages, M(Na).
Cell research
Zhang WC,Zheng XJ,Du LJ,Sun JY,Shen ZX,Shi C,Sun S,Zhang Z,Chen XQ,Qin M,Liu X,Tao J,Jia L,Fan HY,Zhou B,Yu Y,Ying H,Hui L,Liu X,Yi X,Liu X,Zhang L,Duan SZ
11-0112 was used in Flow cytometry/Cell sorting to investigate the mechanisms of high salt in disease risk, showing that it primes a specific activation state of macrophages.
Sat Aug 01 00:00:00 EDT 2015
Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes.
Nature genetics
Hobbs RP,DePianto DJ,Jacob JT,Han MC,Chung BM,Batazzi AS,Poll BG,Guo Y,Han J,Ong S,Zheng W,Taube JM,Čiháková D,Wan F,Coulombe PA
11-0112 was used in Flow cytometry/Cell sorting to provide new insight into keratin intermediate filament and Aire function, as well as a molecular basis for the K17-dependent amplification of inflammatory and immune responses in diseased epithelia.
Sat Aug 01 00:00:00 EDT 2015
Activity of the Type II JAK2 Inhibitor CHZ868 in B Cell Acute Lymphoblastic Leukemia.
Cancer cell
Wu SC,Li LS,Kopp N,Montero J,Chapuy B,Yoda A,Christie AL,Liu H,Christodoulou A,van Bodegom D,van der Zwet J,Layer JV,Tivey T,Lane AA,Ryan JA,Ng SY,DeAngelo DJ,Stone RM,Steensma D,Wadleigh M,Harris M,Mandon E,Ebel N,Andraos R,Romanet V,Dölemeyer A,Sterker D,Zender M,Rodig SJ,Murakami M,Hofmann F,Kuo F,Eck MJ,Silverman LB,Sallan SE,Letai A,Baffert F,Vangrevelinghe E,Radimerski T,Gaul C,Weinstock DM
11-0112 was used in Flow cytometry/Cell sorting to support the testing of type II JAK2 inhibition in patients with JAK2-dependent leukemias and other disorders.
Mon Jul 13 00:00:00 EDT 2015
Peroxisomal lipid synthesis regulates inflammation by sustaining neutrophil membrane phospholipid composition and viability.
Cell metabolism
Lodhi IJ,Wei X,Yin L,Feng C,Adak S,Abou-Ezzi G,Hsu FF,Link DC,Semenkovich CF
11-0112 was used in Flow cytometry/Cell sorting to investigate the immunometabolism pathway by which peroxisomal lipid synthesis regulates neutrophil development and inflammation.
Tue Jan 06 00:00:00 EST 2015
CD93 Marks a Non-Quiescent Human Leukemia Stem Cell Population and Is Required for Development of MLL-Rearranged Acute Myeloid Leukemia.
Cell stem cell
Iwasaki M,Liedtke M,Gentles AJ,Cleary ML
11-0112 was used in Flow cytometry/Cell sorting to study how CD93 expression may indicate leukaemia initiating stem cells that have a MLL gene rearrangement.
Thu Oct 01 00:00:00 EDT 2015
Low-dose TNF augments fracture healing in normal and osteoporotic bone by up-regulating the innate immune response.
EMBO molecular medicine
Chan JK,Glass GE,Ersek A,Freidin A,Williams GA,Gowers K,Espirito Santo AI,Jeffery R,Otto WR,Poulsom R,Feldmann M,Rankin SM,Horwood NJ,Nanchahal J
11-0112 was used in Flow cytometry/Cell sorting to investigate the optimal treatment course of low-dose recombinant human TNF to augment bone fracture repair in a mouse model, and the major cells involved.
Fri May 01 00:00:00 EDT 2015
The histone methyltransferase SETDB1 represses endogenous and exogenous retroviruses in B lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America
Collins PL,Kyle KE,Egawa T,Shinkai Y,Oltz EM
11-0112 was used in Flow cytometry/Cell sorting to investigate mechanisms of endogenous retrovirus repression in differentiated cells.
Tue Jul 07 00:00:00 EDT 2015
Mast cells boost myeloid-derived suppressor cell activity and contribute to the development of tumor-favoring microenvironment.
Cancer immunology research
Danelli L,Frossi B,Gri G,Mion F,Guarnotta C,Bongiovanni L,Tripodo C,Mariuzzi L,Marzinotto S,Rigoni A,Blank U,Colombo MP,Pucillo CE
11-0112 was used in Flow cytometry/Cell sorting to examine the interactions between myeloid-derived suppressor cells and mast cells in the mucosa of patients with colon carcinoma.
Thu Jan 01 00:00:00 EST 2015
Spatiotemporal expression dynamics of selectins govern the sequential extravasation of neutrophils and monocytes in the acute inflammatory response.
Arteriosclerosis, thrombosis, and vascular biology
Zuchtriegel G,Uhl B,Hessenauer ME,Kurz AR,Rehberg M,Lauber K,Krombach F,Reichel CA
11-0112 was used in Flow cytometry/Cell sorting to provide novel insights into the mechanisms initiating the sequential infiltration of the perivascular tissue by neutrophils and monocytes in the acute inflammatory response.
Wed Apr 01 00:00:00 EDT 2015
Limited Efficacy of Antibacterial Vaccination Against Secondary Serotype 3 Pneumococcal Pneumonia Following Influenza Infection.
The Journal of infectious diseases
Metzger DW,Furuya Y,Salmon SL,Roberts S,Sun K
11-0112 was used in Flow cytometry/Cell sorting to show that antibacterial vaccination is only partially effective in protection against secondary serotype 3 pneumococcal pneumonia following influenza.
Sat Aug 01 00:00:00 EDT 2015
Premature thymic involution is independent of structural plasticity of the thymic stroma.
European journal of immunology
Franckaert D,Schlenner SM,Heirman N,Gill J,Skogberg G,Ekwall O,Put K,Linterman MA,Dooley J,Liston A
11-0112 was used in Flow cytometry/Cell sorting to investigate thymic involution in FVB/N mice, showing that disruption of the epithelial-endothelial relationship and a progressive loss of pro-T cells precedes involution, and loss of pro-T cells is sufficient to drive premature involution, suggesting that pro-T cells are the main driver of involution.
Fri May 01 00:00:00 EDT 2015
Cancer-associated fibroblast-targeted strategy enhances antitumor immune responses in dendritic cell-based vaccine.
Cancer science
Ohshio Y,Teramoto K,Hanaoka J,Tezuka N,Itoh Y,Asai T,Daigo Y,Ogasawara K
11-0112 was used in Flow cytometry/Cell sorting to study the immunosuppressive trait of CAFs, and systematically explore the alteration of tumour-associated immune responses by CAF-targeted therapy.
Sun Feb 01 00:00:00 EST 2015
Cancer-associated fibroblast-targeted strategy enhances antitumor immune responses in dendritic cell-based vaccine.
Cancer science
Ohshio Y,Teramoto K,Hanaoka J,Tezuka N,Itoh Y,Asai T,Daigo Y,Ogasawara K
11-0112 was used in Flow cytometry/Cell sorting to study the immunosuppressive trait of CAFs, and systematically explore the alteration of tumour-associated immune responses by CAF-targeted therapy.
Sun Feb 01 00:00:00 EST 2015
Proresolving actions of a new resolvin D1 analog mimetic qualifies as an immunoresolvent.
American journal of physiology. Lung cellular and molecular physiology
Orr SK,Colas RA,Dalli J,Chiang N,Serhan CN
11-0112 was used in Flow cytometry/Cell sorting to investigate a synthetic analogue of resolvin D1 and asprin-triggered BDA-resolvin D1.
Fri May 01 00:00:00 EDT 2015
Anti-alpha-toxin monoclonal antibody and antibiotic combination therapy improves disease outcome and accelerates healing in a Staphylococcus aureus dermonecrosis model.
Antimicrobial agents and chemotherapy
Hilliard JJ,Datta V,Tkaczyk C,Hamilton M,Sadowska A,Jones-Nelson O,O'Day T,Weiss WJ,Szarka S,Nguyen V,Prokai L,Suzich J,Stover CK,Sellman BR
11-0112 was used in Flow cytometry/Cell sorting to characterise MEDI4893* and its therapeutic activity in a dermonecrosis model, showing that MEDI4893* and antibiotic combination therapy improves disease outcome.
Thu Jan 01 00:00:00 EST 2015
mir-181a-1/b-1 Modulates Tolerance through Opposing Activities in Selection and Peripheral T Cell Function.
Journal of immunology (Baltimore, Md. : 1950)
Schaffert SA,Loh C,Wang S,Arnold CP,Axtell RC,Newell EW,Nolan G,Ansel KM,Davis MM,Steinman L,Chen CZ
11-0112 was used in Flow cytometry/Cell sorting to explore the physiological control of tolerance by manipulating microRNA gene products.
Sat Aug 15 00:00:00 EDT 2015
Immune suppressive effects of tonsil-derived mesenchymal stem cells on mouse bone-marrow-derived dendritic cells.
Stem cells international
Park M,Kim YH,Ryu JH,Woo SY,Ryu KH
11-0112 was used in Flow cytometry/Cell sorting to suggest that tonsil-derived mesenchymal stem cells could be used as a novel source of stem cell therapy as immune modulators.
Wed Mar 18 00:00:00 EDT 2015
Mouse dental pulp stem cells support human umbilical cord blood-derived hematopoietic stem/progenitor cells in vitro.
Cell transplantation
Nakatsuka R,Matsuoka Y,Uemura Y,Sumide K,Iwaki R,Takahashi M,Fujioka T,Sasaki Y,Sonoda Y
11-0112 was used in Flow cytometry/Cell sorting to demonstrate that prospectively isolated murine PDGFRα and Sca-1 double-positive dental pulp stem cells could support primitive human CD34+ and CD34- hematopoietic stem cells in vitro.
Wed Sep 16 00:00:00 EDT 2015
Toll-Like receptor 2 (TLR2) and TLR9 play opposing roles in host innate immunity against Salmonella enterica serovar Typhimurium infection.
Infection and immunity
Zhan R,Han Q,Zhang C,Tian Z,Zhang J
11-0112 was used in Flow cytometry/Cell sorting to investigate the roles of TLR2 and TLR9 in regulating innate immunity against oral infection of Salmonella enterica serovar Typhimurium in mice.
Wed Apr 01 00:00:00 EDT 2015
Injectable cryogel-based whole-cell cancer vaccines.
Nature communications
Bencherif SA,Warren Sands R,Ali OA,Li WA,Lewin SA,Braschler TM,Shih TY,Verbeke CS,Bhatta D,Dranoff G,Mooney DJ
11-0112 was used in Flow cytometry/Cell sorting to investigate cancer vaccines based on injectable whole-cell cryogels.
Wed Aug 12 00:00:00 EDT 2015
Mesenchymal Stem Cells Reduce Murine Atherosclerosis Development.
Scientific reports
Frodermann V,van Duijn J,van Pel M,van Santbrink PJ,Bot I,Kuiper J,de Jager SC
11-0112 was used in Flow cytometry/Cell sorting to study how MSC treatment affects not only inflammatory responses but also significantly reduces dyslipidaemia in mice.
Thu Oct 22 00:00:00 EDT 2015
Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases.
Nature communications
Kanno A,Tanimura N,Ishizaki M,Ohko K,Motoi Y,Onji M,Fukui R,Shimozato T,Yamamoto K,Shibata T,Sano S,Sugahara-Tobinai A,Takai T,Ohto U,Shimizu T,Saitoh S,Miyake K
11-0112 was used in Flow cytometry/Cell sorting to show that Toll-like receptor 7 (TLR7) is present on the cell surface of immune cells and that TLR7 responses can be inhibited by an anti-TLR7 antibody.
Wed Feb 04 00:00:00 EST 2015
Critical role for syndecan-4 in dendritic cell migration during development of allergic airway inflammation.
Nature communications
Polte T,Petzold S,Bertrand J,Schütze N,Hinz D,Simon JC,Lehmann I,Echtermeyer F,Pap T,Averbeck M
11-0112 was used in Flow cytometry/Cell sorting to demonstrate that SDC4 plays an important role in asthma induction and indicate SDC4 as a possible target for therapeutic intervention in this disease.
Mon Jul 13 00:00:00 EDT 2015
Virulence-Dependent Alterations in the Kinetics of Immune Cells during Pulmonary Infection by Mycobacterium tuberculosis.
PloS one
Kim WS,Kim JS,Cha SB,Han SJ,Kim H,Kwon KW,Kim SJ,Eum SY,Cho SN,Shin SJ
11-0112 was used in Blocking experiments to compare the bacterial burden, inflammation and kinetics of immune cells during aerogenic infection in the lung between laboratory-adapted strains (Mtb H37Rv and H37Ra) and Mtb K strain.
Mon Jun 27 00:00:00 EDT 2016
Virulence-Dependent Alterations in the Kinetics of Immune Cells during Pulmonary Infection by Mycobacterium tuberculosis.
PloS one
Kim WS,Kim JS,Cha SB,Han SJ,Kim H,Kwon KW,Kim SJ,Eum SY,Cho SN,Shin SJ
11-0112 was used in Blocking experiments to compare the bacterial burden, inflammation and kinetics of immune cells during aerogenic infection in the lung between laboratory-adapted strains (Mtb H37Rv and H37Ra) and Mtb K strain.
Mon Jun 27 00:00:00 EDT 2016
Myeloid cell-derived inducible nitric oxide synthase suppresses M1 macrophage polarization.
Nature communications
Lu G,Zhang R,Geng S,Peng L,Jayaraman P,Chen C,Xu F,Yang J,Li Q,Zheng H,Shen K,Wang J,Liu X,Wang W,Zheng Z,Qi CF,Si C,He JC,Liu K,Lira SA,Sikora AG,Li L,Xiong H
11-0112 was used in Flow cytometry/Cell sorting to show that iNOS-deficient mice display enhanced classically activated M1 macrophage polarization without major effects on alternatively activated M2 macrophages.
Fri Mar 27 00:00:00 EDT 2015
Telomerase Deficiency Causes Alveolar Stem Cell Senescence-associated Low-grade Inflammation in Lungs.
The Journal of biological chemistry
Chen R,Zhang K,Chen H,Zhao X,Wang J,Li L,Cong Y,Ju Z,Xu D,Williams BR,Jia J,Liu JP
11-0112 was used in Flow cytometry/Cell sorting to elucidate the mechanisms by which TERC and TERT participate in lung diseases.
Fri Dec 25 00:00:00 EST 2015
Glycoprotein Nonmetastatic Melanoma B (Gpnmb)-Positive Macrophages Contribute to the Balance between Fibrosis and Fibrolysis during the Repair of Acute Liver Injury in Mice.
PloS one
Kumagai K,Tabu K,Sasaki F,Takami Y,Morinaga Y,Mawatari S,Hashimoto S,Tanoue S,Kanmura S,Tamai T,Moriuchi A,Uto H,Tsubouchi H,Ido A
11-0112 was used in Flow cytometry/Cell sorting to identify the immune cells which respond to acute liver injury and assess their contribution to the repair process.
Mon Jun 20 00:00:00 EDT 2016
Interleukin-15 Constrains Mucosal T Helper 17 Cell Generation: Influence of Mononuclear Phagocytes.
PloS one
Yu H,Sui Y,Wang Y,Sato N,Frey B,Xia Z,Waldmann TA,Berzofsky J
11-0112 was used in Flow cytometry/Cell sorting to investigate the role of IL-15 in regulating differentiation of T helper cell subsets, showing that it constrains mucosal T helper 17 cell generation.
Mon Jun 20 00:00:00 EDT 2016
DNase II-dependent DNA digestion is required for DNA sensing by TLR9.
Nature communications
Chan MP,Onji M,Fukui R,Kawane K,Shibata T,Saitoh S,Ohto U,Shimizu T,Barber GN,Miyake K
11-0112 was used in Flow cytometry/Cell sorting to study the response to two types of TLR9 ligands in the dendritic cells of DNase II-deficient mice.
Tue Jan 20 00:00:00 EST 2015
Biliary repair and carcinogenesis are mediated by IL-33-dependent cholangiocyte proliferation.
The Journal of clinical investigation
Li J,Razumilava N,Gores GJ,Walters S,Mizuochi T,Mourya R,Bessho K,Wang YH,Glaser SS,Shivakumar P,Bezerra JA
11-0112 was used in Flow cytometry/Cell sorting to demonstrate the role of the Th2-promoting cytokine, IL-33, in cholangiocyte proliferation.
Tue Jul 01 00:00:00 EDT 2014
Lymph node fibroblastic reticular cell transplants show robust therapeutic efficacy in high-mortality murine sepsis.
Science translational medicine
Fletcher AL,Elman JS,Astarita J,Murray R,Saeidi N,D'Rozario J,Knoblich K,Brown FD,Schildberg FA,Nieves JM,Heng TS,Boyd RL,Turley SJ,Parekkadan B
11-0112 was used in Flow cytometry/Cell sorting to characterise a novel population of immune-specialised myofibroblasts derived from lymph node tissue, termed fibroblastic reticular cells.
Wed Aug 13 00:00:00 EDT 2014
Myeloid-derived suppressor cell function is diminished in aspirin-triggered allergic airway hyperresponsiveness in mice.
The Journal of allergy and clinical immunology
Shi M,Shi G,Tang J,Kong D,Bao Y,Xiao B,Zuo C,Wang T,Wang Q,Shen Y,Wang H,Funk CD,Zhou J,Yu Y
11-0112 was used in Flow cytometry/Cell sorting to characterise myeloid-derived suppressor cell accumulation and pathogenic functions in allergic airway inflammation mediated by COX-1 deficiency or aspirin treatment in mice.
Sat Nov 01 00:00:00 EDT 2014
S100a8/a9 released by CD11b+Gr1+ neutrophils activates cardiac fibroblasts to initiate angiotensin II-Induced cardiac inflammation and injury.
Hypertension (Dallas, Tex. : 1979)
Wu Y,Li Y,Zhang C,A X,Wang Y,Cui W,Li H,Du J
11-0112 was used in Flow cytometry/Cell sorting to elucidate the initial factors that trigger the inflammatory cascade during angiotensin II-induced cardiovascular injury.
Sun Jun 01 00:00:00 EDT 2014
Immunogenicity of undifferentiated and differentiated allogeneic mouse mesenchymal stem cells.
Journal of tissue engineering
Mukonoweshuro B,Brown CJ,Fisher J,Ingham E
11-0112 was used in Flow cytometry/Cell sorting to determine that although mesenchymal stem cells possess immunosuppressive properties, they may not be immunoprivileged.
Fri May 09 00:00:00 EDT 2014
Wnt5a regulates hematopoietic stem cell proliferation and repopulation through the Ryk receptor.
Stem cells (Dayton, Ohio)
Povinelli BJ,Nemeth MJ
11-0112 was used in Flow cytometry/Cell sorting to study whether Ryk protein regulates the response of haematopoietic stem cells to Wnt5a.
Wed Jan 01 00:00:00 EST 2014
Hepatic stellate cells promote tumor progression by enhancement of immunosuppressive cells in an orthotopic liver tumor mouse model.
Laboratory investigation; a journal of technical methods and pathology
Zhao W,Zhang L,Xu Y,Zhang Z,Ren G,Tang K,Kuang P,Zhao B,Yin Z,Wang X
11-0112 was used in Flow cytometry/Cell sorting to study the complex tumor-host interactions in hepatocellular carcinoma, specifically how the immunosuppressive properties of hepatic stellate cells may contribute to hepatocellular carcinoma occurrence and development..
Sat Feb 01 00:00:00 EST 2014
Dynamic changes in macrophage activation and proliferation during the development and resolution of intestinal inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Little MC,Hurst RJ,Else KJ
11-0112 was used in Flow cytometry/Cell sorting to study intestinal inflammation and the dynamic changes in macrophage activation and proliferation that occur during this process.
Sat Nov 01 00:00:00 EDT 2014
Intrahepatic innate lymphoid cells secrete IL-17A and IL-17F that are crucial for T cell priming in viral infection.
Journal of immunology (Baltimore, Md. : 1950)
Jie Z,Liang Y,Hou L,Dong C,Iwakura Y,Soong L,Cong Y,Sun J
11-0112 was used in Flow cytometry/Cell sorting to investigate the source and regulation of the IL-17 surge in the liver microenvironment that occurs early in the response to viral infection.
Tue Apr 01 00:00:00 EDT 2014
Central role of conventional dendritic cells in regulation of bone marrow release and survival of neutrophils.
Journal of immunology (Baltimore, Md. : 1950)
Jiao J,Dragomir AC,Kocabayoglu P,Rahman AH,Chow A,Hashimoto D,Leboeuf M,Kraus T,Moran T,Carrasco-Avino G,Friedman SL,Merad M,Aloman C
11-0112 was used in Flow cytometry/Cell sorting to investigate the role of dendritic cells in neutrophil homeostasis, showing a central role in regulation of bone marrow release and survival of neutrophils.
Tue Apr 01 00:00:00 EDT 2014
Anti-inflammatory functions of protein C require RAGE and ICAM-1 in a stimulus-dependent manner.
Mediators of inflammation
Braach N,Buschmann K,Pflaum J,Hudalla H,Koch L,Ryschich E,Poeschl J,Frommhold D
11-0112 was used in Flow cytometry/Cell sorting to show that RAGE and ICAM-1 are cooperatively involved in protein C-induced inhibition of leukocyte recruitment.
Sat Feb 07 00:00:00 EST 2015
Tranilast inhibits the function of cancer-associated fibroblasts responsible for the induction of immune suppressor cell types.
Scandinavian journal of immunology
Ohshio Y,Hanaoka J,Kontani K,Teramoto K
11-0112 was used in Flow cytometry/Cell sorting to elucidate the interaction between cancer-associated fibroblasts and immune suppressor cells.
Mon Dec 01 00:00:00 EST 2014
HIF-α/MIF and NF-κB/IL-6 axes contribute to the recruitment of CD11b+Gr-1+ myeloid cells in hypoxic microenvironment of HNSCC.
Neoplasia (New York, N.Y.)
Zhu G,Tang Y,Geng N,Zheng M,Jiang J,Li L,Li K,Lei Z,Chen W,Fan Y,Ma X,Li L,Wang X,Liang X
11-0112 was used in Flow cytometry/Cell sorting to reveal HIF-α/MIF and NF-κB/IL-6 interaction plays a role in hypoxia-induced accumulation of CD11b+Gr-1+ myeloid cells and tumour growth.
Sat Feb 01 00:00:00 EST 2014
Regulation of methylglyoxal-elicited leukocyte recruitment by endothelial SGK1/GSK3 signaling.
Biochimica et biophysica acta
Su Y,Qadri SM,Cayabyab FS,Wu L,Liu L
11-0112 was used in Flow cytometry/Cell sorting to investigate the signal transduction of leukocyte- and endothelial-expressed PI3K, GSK3 and SGK1 in the regulation of methylglyoxal-elicited leukocyte recruitment.
Sat Nov 01 00:00:00 EDT 2014
Influenza vaccination accelerates recovery of ferrets from lymphopenia.
PloS one
Music N,Reber AJ,Lipatov AS,Kamal RP,Blanchfield K,Wilson JR,Donis RO,Katz JM,York IA
11-0112 was used in Flow cytometry/Cell sorting to assess the effectiveness of the influenza vaccine in restoring normal blood cell levels.
Wed Oct 07 00:00:00 EDT 2015
Neutrophils contribute to excess serum BAFF levels and promote CD4+ T cell and B cell responses in lupus-prone mice.
PloS one
Coquery CM,Wade NS,Loo WM,Kinchen JM,Cox KM,Jiang C,Tung KS,Erickson LD
11-0112 was used in Immunohistochemistry to analyse the phenotype, localisation and function of neutrophils in the spleens of healthy mice and congenic lupus-prone mice.
Fri Nov 06 00:00:00 EST 2015
Neutrophils contribute to excess serum BAFF levels and promote CD4+ T cell and B cell responses in lupus-prone mice.
PloS one
Coquery CM,Wade NS,Loo WM,Kinchen JM,Cox KM,Jiang C,Tung KS,Erickson LD
11-0112 was used in Immunohistochemistry to analyse the phenotype, localisation and function of neutrophils in the spleens of healthy mice and congenic lupus-prone mice.
Fri Nov 06 00:00:00 EST 2015
Tim-3 negatively mediates natural killer cell function in LPS-induced endotoxic shock.
PloS one
Hou H,Liu W,Wu S,Lu Y,Peng J,Zhu Y,Lu Y,Wang F,Sun Z
11-0112 was used in Flow cytometry/Cell sorting to study the role of Tim-3 in the regulation of natural killer cells following LPS-induced shock.
Mon Jul 06 00:00:00 EDT 2015
STAT3 restrains RANK- and TLR4-mediated signalling by suppressing expression of the E2 ubiquitin-conjugating enzyme Ubc13.
Nature communications
Zhang H,Hu H,Greeley N,Jin J,Matthews AJ,Ohashi E,Caetano MS,Li HS,Wu X,Mandal PK,McMurray JS,Moghaddam SJ,Sun SC,Watowich SS
11-0112 was used in Flow cytometry/Cell sorting to investigate the mechanism by which STAT3 curbs pro-inflammatory cytokine production mediated by NF-κB signalling, showing that it restrains signalling by suppressing expression of Ubc13.
Mon Dec 15 00:00:00 EST 2014
Brugia malayi microfilariae induce a regulatory monocyte/macrophage phenotype that suppresses innate and adaptive immune responses.
PLoS neglected tropical diseases
O'Regan NL,Steinfelder S,Venugopal G,Rao GB,Lucius R,Srikantam A,Hartmann S
11-0112 was used in Flow cytometry/Cell sorting to show that monocytes stimulated with Brugia malayi microfilarial lysate develop a defined regulatory phenotype.
Wed Oct 01 00:00:00 EDT 2014
p85α recruitment by the CD300f phosphatidylserine receptor mediates apoptotic cell clearance required for autoimmunity suppression.
Nature communications
Tian L,Choi SC,Murakami Y,Allen J,Morse HC,Qi CF,Krzewski K,Coligan JE
11-0112 was used in Flow cytometry/Cell sorting to identify the mechanism and role of mouse CD300f in apoptotic cell phagocytosis and the maintenance of immune homeostasis.
Mon Mar 07 00:00:00 EST 2016
Novel apidaecin 1b analogs with superior serum stabilities for treatment of infections by gram-negative pathogens.
Antimicrobial agents and chemotherapy
Berthold N,Czihal P,Fritsche S,Sauer U,Schiffer G,Knappe D,Alber G,Hoffmann R
11-0112 was used in Flow cytometry/Cell sorting to study the effect of modifications to the C-terminus of Api88 on its rate of proteolysis.
Tue Jan 01 00:00:00 EST 2013
Heme oxygenase-1 expression protects the heart from acute injury caused by inducible Cre recombinase.
Laboratory investigation; a journal of technical methods and pathology
Hull TD,Bolisetty S,DeAlmeida AC,Litovsky SH,Prabhu SD,Agarwal A,George JF
11-0112 was used in Flow cytometry/Cell sorting to demonstrate that HO-1 induction prevents the depression of cardiac function imposed by Cre-induced cardiac toxicity.
Thu Aug 01 00:00:00 EDT 2013
Mast cell-deficient Kit(W-sh) "Sash" mutant mice display aberrant myelopoiesis leading to the accumulation of splenocytes that act as myeloid-derived suppressor cells.
Journal of immunology (Baltimore, Md. : 1950)
Michel A,Schüler A,Friedrich P,Döner F,Bopp T,Radsak M,Hoffmann M,Relle M,Distler U,Kuharev J,Tenzer S,Feyerabend TB,Rodewald HR,Schild H,Schmitt E,Becker M,Stassen M
11-0112 was used in Flow cytometry/Cell sorting to demonstrate the broad effects that the Kit(W-sh) mutation has on key steps in myelopoiesis.
Sat Jun 01 00:00:00 EDT 2013
Gene expression changes in aging retinal microglia: relationship to microglial support functions and regulation of activation.
Neurobiology of aging
Ma W,Cojocaru R,Gotoh N,Gieser L,Villasmil R,Cogliati T,Swaroop A,Wong WT
11-0112 was used in Flow cytometry/Cell sorting to investigate age-related changes in gene expression patterns in microglia.
Tue Oct 01 00:00:00 EDT 2013
Pharmacological inhibition of p38 mitogen-activated protein kinases affects KC/CXCL1-induced intraluminal crawling, transendothelial migration, and chemotaxis of neutrophils in vivo.
Mediators of inflammation
Xu N,Hossain M,Liu L
11-0112 was used in Flow cytometry/Cell sorting to study the effect of a p38 MAPK inhibitor on Mac-1 expression in neutrophils after stimulation with chemokine KC.
Mon Aug 19 00:00:00 EDT 2013
Uterine natural killer cells severely decrease in number at gestation day 6 in mice.
Biology of reproduction
Takashima A,Ishikawa F,Kuwabara T,Tanaka Y,Kinoshita T,Ito M,Kakiuchi T
11-0112 was used in Flow cytometry/Cell sorting to study how uterine NK cells or their precursors migrate into the uterus, mature, and produce interferon-gamma to support pregnancy in mice.
Tue Oct 01 00:00:00 EDT 2013
Proximal tubule PPARα attenuates renal fibrosis and inflammation caused by unilateral ureteral obstruction.
American journal of physiology. Renal physiology
Li S,Mariappan N,Megyesi J,Shank B,Kannan K,Theus S,Price PM,Duffield JS,Portilla D
11-0112 was used in Flow cytometry/Cell sorting to study how proximal tubule PPARα attenuates renal fibrosis and inflammation caused by unilateral ureteral obstruction.
Sun Sep 01 00:00:00 EDT 2013
Kinetics of neutrophils in mice exposed to radiation and/or granulocyte colony-stimulating factor treatment.
Radiation research
Romero-Weaver AL,Wan XS,Diffenderfer ES,Lin L,Kennedy AR
11-0112 was used in Flow cytometry/Cell sorting to evaluate the involvement of SPE-like protons and γ radiation on neutropenia observed in astronauts following radiation exposure using a mouse model system.
Thu Aug 01 00:00:00 EDT 2013
Staphylococcus aureus alpha toxin suppresses effective innate and adaptive immune responses in a murine dermonecrosis model.
PloS one
Tkaczyk C,Hamilton MM,Datta V,Yang XP,Hilliard JJ,Stephens GL,Sadowska A,Hua L,O'Day T,Suzich J,Stover CK,Sellman BR
11-0112 was used in Flow cytometry/Cell sorting to investigate the effect of alpha toxin on the immune response against soft tissue infections, showing that alpha toxin suppresses effective innate and adaptive immune responses.
Mon Jun 23 00:00:00 EDT 2014
A survey of ex vivo/in vitro transduction efficiency of mammalian primary cells and cell lines with Nine natural adeno-associated virus (AAV1-9) and one engineered adeno-associated virus serotype.
Virology journal
Ellis BL,Hirsch ML,Barker JC,Connelly JP,Steininger RJ,Porteus MH
11-0112 was used in Flow cytometry/Cell sorting to produce a comprehensive study of the transduction efficiency of viral vectors.
Wed Mar 06 00:00:00 EST 2013
Lack of endogenous IL-10 enhances production of proinflammatory cytokines and leads to Brucella abortus clearance in mice.
PloS one
Corsetti PP,de Almeida LA,Carvalho NB,Azevedo V,Silva TM,Teixeira HC,Faria AC,Oliveira SC
11-0112 was used in Flow cytometry/Cell sorting to evaluate the contribution of IL-10 in host immune response and pathology during B. abortus infection.
Sun Jun 15 00:00:00 EDT 2014
γδ T cells recognize a microbial encoded B cell antigen to initiate a rapid antigen-specific interleukin-17 response.
Immunity
Zeng X,Wei YL,Huang J,Newell EW,Yu H,Kidd BA,Kuhns MS,Waters RW,Davis MM,Weaver CT,Chien YH
11-0112 was used in Flow cytometry/Cell sorting to study the γδ T cell response to the algae protein, phycoerythrin.
Fri Sep 21 00:00:00 EDT 2012
Transcription factor RORα is critical for nuocyte development.
Nature immunology
Wong SH,Walker JA,Jolin HE,Drynan LF,Hams E,Camelo A,Barlow JL,Neill DR,Panova V,Koch U,Radtke F,Hardman CS,Hwang YY,Fallon PG,McKenzie AN
11-0112 was used in Flow cytometry/Cell sorting to study how nuocytes arose in the bone marrow and differentiated from common lymphoid progenitors, indicating they are a distinct, previously unknown member of the lymphoid lineage.
Sun Jan 22 00:00:00 EST 2012
Concomitant inactivation of Rb and E2f8 in hematopoietic stem cells synergizes to induce severe anemia.
Blood
Hu T,Ghazaryan S,Sy C,Wiedmeyer C,Chang V,Wu L
11-0112 was used in Flow cytometry/Cell sorting to reveal the specificity of E2F8 in mediating Rb function in erythropoiesis.
Thu May 10 00:00:00 EDT 2012
PGD2-CRTH2 pathway promotes tubulointerstitial fibrosis.
Journal of the American Society of Nephrology : JASN
Ito H,Yan X,Nagata N,Aritake K,Katsumata Y,Matsuhashi T,Nakamura M,Hirai H,Urade Y,Asano K,Kubo M,Utsunomiya Y,Hosoya T,Fukuda K,Sano M
11-0112 was used in Flow cytometry/Cell sorting to explore the contribution of L-PGDS to the development of chronic kidney disease.
Thu Nov 01 00:00:00 EDT 2012
CD73-deficient mice are resistant to carcinogenesis.
Cancer research
Stagg J,Beavis PA,Divisekera U,Liu MC,Möller A,Darcy PK,Smyth MJ
11-0112 was used in Flow cytometry/Cell sorting to investigate the contribution of CD73 to autochthonous tumour formation.
Tue May 01 00:00:00 EDT 2012
Ymer acts as a multifunctional regulator in nuclear factor-κB and Fas signaling pathways.
Molecular medicine (Cambridge, Mass.)
Tsukiyama T,Matsuda-Tsukiyama M,Bohgaki M,Terai S,Tanaka S,Hatakeyama S
11-0112 was used in Flow cytometry/Cell sorting to explore the role of Ymer as a positive or negative regulator in several signalling pathways in mice.
Wed May 09 00:00:00 EDT 2012
Protective role of commensals against Clostridium difficile infection via an IL-1β-mediated positive-feedback loop.
Journal of immunology (Baltimore, Md. : 1950)
Hasegawa M,Kamada N,Jiao Y,Liu MZ,Núñez G,Inohara N
11-0112 was used in Flow cytometry/Cell sorting to reveal a crucial role for translocated commensals in the recruitment of neutrophils to the C. difficile infected intestine.
Sat Sep 15 00:00:00 EDT 2012
Losartan inhibits conventional dendritic cell maturation and Th1 and Th17 polarization responses: Νovel mechanisms of preventive effects on lipopolysaccharide-induced acute lung injury.
International journal of molecular medicine
Liu J,Zhang PS,Yu Q,Liu L,Yang Y,Guo FM,Qiu HB
11-0112 was used in Flow cytometry/Cell sorting to demonstrate that losartan suppresses conventional dendritic cell maturation and Th1 and Th17 polarization responses.
Wed Feb 01 00:00:00 EST 2012
Impaired innate immunity in mice deficient in interleukin-1 receptor-associated kinase 4 leads to defective type 1 T cell responses, B cell expansion, and enhanced susceptibility to infection with Toxoplasma gondii.
Infection and immunity
Béla SR,Dutra MS,Mui E,Montpetit A,Oliveira FS,Oliveira SC,Arantes RM,Antonelli LR,McLeod R,Gazzinelli RT
11-0112 was used in Flow cytometry/Cell sorting to investigate the role of IRAK4 in Toxoplasma gondii infection, showing that deficiency leads to impaired innate immunity.
Sat Dec 01 00:00:00 EST 2012
High susceptibility to lipopolysaccharide-induced lethal shock in encephalomyocarditis virus-infected mice.
Scientific reports
Ohtaki H,Ito H,Hoshi M,Osawa Y,Takamatsu M,Hara A,Ishikawa T,Moriwaki H,Saito K,Seishima M
11-0112 was used in Flow cytometry/Cell sorting to examine and explore the effect of lipopolysaccharide on encephalomyocarditis virus-infected mice.
Fri Apr 12 00:00:00 EDT 2013
Deleterious effect of the IL-23/IL-17A axis and γδT cells on left ventricular remodeling after myocardial infarction.
Journal of the American Heart Association
Yan X,Shichita T,Katsumata Y,Matsuhashi T,Ito H,Ito K,Anzai A,Endo J,Tamura Y,Kimura K,Fujita J,Shinmura K,Shen W,Yoshimura A,Fukuda K,Sano M
11-0112 was used in Flow cytometry/Cell sorting to explore potential immune pathways involved in left ventricular remodelling as possible preventative therapeutic options.
Mon Oct 01 00:00:00 EDT 2012
Adoptive Transfer of Isolated Bone Marrow Neutrophils.
Bio-protocol
Tosello Boari J,Acosta Rodríguez E
11-0112 was used in Flow cytometry/Cell sorting to examine the role of isolated bone marrow neutrophils during inflammation, infection, and other pathological conditions, following adoptive transfer.
Wed Dec 05 00:00:00 EST 2012
Preferential expression of integrin αvβ8 promotes generation of regulatory T cells by mouse CD103+ dendritic cells.
Gastroenterology
Païdassi H,Acharya M,Zhang A,Mukhopadhyay S,Kwon M,Chow C,Stuart LM,Savill J,Lacy-Hulbert A
11-0112 was used in Flow cytometry/Cell sorting to investigate the ability of CD103(+) dendritic cells to promote Treg generation through activation of TGF-β by preferential expression of αvβ8.
Tue Nov 01 00:00:00 EDT 2011
A critical role for SOCS3 in innate resistance to Toxoplasma gondii.
Cell host & microbe
Whitmarsh RJ,Gray CM,Gregg B,Christian DA,May MJ,Murray PJ,Hunter CA
11-0112 was used in Flow cytometry/Cell sorting to study the role of SOCS3 in suppressing IL-6 signalling during immune responses to T. gondii infection.
Thu Sep 15 00:00:00 EDT 2011
Virus-induced tumor inflammation facilitates effective DC cancer immunotherapy in a Treg-dependent manner in mice.
The Journal of clinical investigation
Woller N,Knocke S,Mundt B,Gürlevik E,Strüver N,Kloos A,Boozari B,Schache P,Manns MP,Malek NP,Sparwasser T,Zender L,Wirth TC,Kubicka S,Kühnel F
11-0112 was used in Flow cytometry/Cell sorting to highlight viruses as attractive tools for eliciting effective antitumour responses upon DC vaccination.
Fri Jul 01 00:00:00 EDT 2011
The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance.
The Journal of experimental medicine
Mortensen M,Soilleux EJ,Djordjevic G,Tripp R,Lutteropp M,Sadighi-Akha E,Stranks AJ,Glanville J,Knight S,Jacobsen SE,Kranc KR,Simon AK
11-0112 was used in Flow cytometry/Cell sorting to show that Atg7 is an essential regulator of adult hematopoietic stem cell maintenance.
Mon Mar 14 00:00:00 EDT 2011
CD73-deficient mice have increased antitumor immunity and are resistant to experimental metastasis.
Cancer research
Stagg J,Divisekera U,Duret H,Sparwasser T,Teng MW,Darcy PK,Smyth MJ
11-0112 was used in Flow cytometry/Cell sorting to study CD73 gene-targeted mice to investigate the role of host-derived CD73 on antitumor immunity and tumor cell metastasis.
Fri Apr 15 00:00:00 EDT 2011
T. brucei infection reduces B lymphopoiesis in bone marrow and truncates compensatory splenic lymphopoiesis through transitional B-cell apoptosis.
PLoS pathogens
Bockstal V,Guirnalda P,Caljon G,Goenka R,Telfer JC,Frenkel D,Radwanska M,Magez S,Black SJ
11-0112 was used in Flow cytometry/Cell sorting to study how infection-induced deletion of transitional B cells prevents replenishment of mature B cell compartments during T. brucei infection.
Wed Jun 01 00:00:00 EDT 2011
CpG and non-CpG oligodeoxynucleotides directly costimulate mouse and human CD4+ T cells through a TLR9- and MyD88-independent mechanism.
Journal of immunology (Baltimore, Md. : 1950)
Landrigan A,Wong MT,Utz PJ
11-0112 was used in Flow cytometry/Cell sorting to study the ability of oligodeoxynucleotides to activate and polarise T cells.
Thu Sep 15 00:00:00 EDT 2011
Nucleotide-binding oligomerization domain 1 mediates recognition of Clostridium difficile and induces neutrophil recruitment and protection against the pathogen.
Journal of immunology (Baltimore, Md. : 1950)
Hasegawa M,Yamazaki T,Kamada N,Tawaratsumida K,Kim YG,Núñez G,Inohara N
11-0112 was used in Flow cytometry/Cell sorting to investigate how Nod1 regulates host susceptibility to C. difficile, and how Nod1-mediated neutrophil recruitment may be an important immune response against the pathogen.
Fri Apr 15 00:00:00 EDT 2011
The actin-bundling protein L-plastin is essential for marginal zone B cell development.
Journal of immunology (Baltimore, Md. : 1950)
Todd EM,Deady LE,Morley SC
11-0112 was used in Flow cytometry/Cell sorting to study the role of the actin-bundling protein L-plastin in B cell chemotaxis.
Thu Sep 15 00:00:00 EDT 2011
Identification of a novel antigen cross-presenting cell type in spleen.
Journal of cellular and molecular medicine
Tan JK,Quah BJ,Griffiths KL,Periasamy P,Hey YY,O'Neill HC
11-0112 was used in Flow cytometry/Cell sorting to study a novel DC type produced by in vitro haematopoiesis which has distinct antigen-presenting potential and reflects a DC subset present also in vivo in spleen.
Sun May 01 00:00:00 EDT 2011
Dectin-1 mediates in vitro phagocytosis of Candida albicans yeast cells by retinal microglia.
FEMS immunology and medical microbiology
Maneu V,Yáñez A,Murciano C,Molina A,Gil ML,Gozalbo D
11-0112 was used in Flow cytometry/Cell sorting to investigate the expression of TLR2 and Dectin-1 in retinal microglia and their involvement in Candida albicans phagocytosis.
Sat Oct 01 00:00:00 EDT 2011
Candida albicans induces selective development of macrophages and monocyte derived dendritic cells by a TLR2 dependent signalling.
PloS one
Yáñez A,Megías J,O'Connor JE,Gozalbo D,Gil ML
11-0112 was used in Flow cytometry/Cell sorting to investigate how C. albicans invasive infection with a low virulence strain results in a rapid expansion of HSPCs.
Tue Feb 28 00:00:00 EST 2012
Batf3-dependent CD11b(low/-) peripheral dendritic cells are GM-CSF-independent and are not required for Th cell priming after subcutaneous immunization.
PloS one
Edelson BT,Bradstreet TR,KC W,Hildner K,Herzog JW,Sim J,Russell JH,Murphy TL,Unanue ER,Murphy KM
11-0112 was used in Flow cytometry/Cell sorting to compare development of peripheral tissue dendritic cells, and susceptibility to experimental autoimmune encephalitis in GM-CSF receptor deficient mice.
Thu Mar 15 00:00:00 EDT 2012
Acute Disruption of Bone Marrow B Lymphopoiesis and Apoptosis of Transitional and Marginal Zone B Cells in the Spleen following a Blood-Stage Plasmodium chabaudi Infection in Mice.
Journal of parasitology research
Bockstal V,Geurts N,Magez S
11-0112 was used in Flow cytometry/Cell sorting to investigate the effects of a blood-stage Plasmodium chabaudi infection in the spleen and bone marrow of mice.
Thu Jul 14 00:00:00 EDT 2011
Role of myeloid-derived suppressor cells in amelioration of experimental autoimmune hepatitis following activation of TRPV1 receptors by cannabidiol.
PloS one
Hegde VL,Nagarkatti PS,Nagarkatti M
11-0112 was used in Flow cytometry/Cell sorting to ameliorate experimental autoimmune hepatitis following activation of TRPV1 receptors in myeloid-derived suppressor cells by cannabidiol.
Fri Apr 01 00:00:00 EDT 2011
Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis.
Proceedings of the National Academy of Sciences of the United States of America
Stagg J,Divisekera U,McLaughlin N,Sharkey J,Pommey S,Denoyer D,Dwyer KM,Smyth MJ
11-0112 was used in Flow cytometry/Cell sorting to investigate the therapeutic potential and mechanism of action of mAb-based therapy against CD73.
Tue Jan 26 00:00:00 EST 2010
T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America
Rodriguez-Manzanet R,Sanjuan MA,Wu HY,Quintana FJ,Xiao S,Anderson AC,Weiner HL,Green DR,Kuchroo VK
11-0112 was used in Flow cytometry/Cell sorting to investigate the significance of interactions between TIM-4 and phophatidylserine, showing that TIM-4 deficiency leads to T and B cell hyperactivity and autoimmunity.
Tue May 11 00:00:00 EDT 2010
The death effector domain protein PEA-15 negatively regulates T-cell receptor signaling.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Pastorino S,Renganathan H,Caliva MJ,Filbert EL,Opoku-Ansah J,Sulzmaier FJ,Gawecka JE,Werlen G,Shaw AS,Ramos JW
11-0112 was used in Flow cytometry/Cell sorting to investigate the physiological function of PEA-15, showing that it negatively regulates T-cell receptor signalling.
Sun Aug 01 00:00:00 EDT 2010
IL-1-induced inflammation promotes development of leishmaniasis in susceptible BALB/c mice.
International immunology
Voronov E,Dotan S,Gayvoronsky L,White RM,Cohen I,Krelin Y,Benchetrit F,Elkabets M,Huszar M,El-On J,Apte RN
11-0112 was used in Flow cytometry/Cell sorting to assess the role of host derived IL-1 on the course of Leishmania major infection in susceptible BLAB/c mice.
Thu Apr 01 00:00:00 EDT 2010
Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells.
Cell stem cell
Somervaille TC,Matheny CJ,Spencer GJ,Iwasaki M,Rinn JL,Witten DM,Chang HY,Shurtleff SA,Downing JR,Cleary ML
11-0112 was used in Flow cytometry/Cell sorting to link the frequency of aberrantly self-renewing progenitor-like cancer stem cells (CSCs) to prognosis in human cancer, namely myeloid leukemia.
Fri Feb 06 00:00:00 EST 2009
An adventitial IL-6/MCP1 amplification loop accelerates macrophage-mediated vascular inflammation leading to aortic dissection in mice.
The Journal of clinical investigation
Tieu BC,Lee C,Sun H,Lejeune W,Recinos A,Ju X,Spratt H,Guo DC,Milewicz D,Tilton RG,Brasier AR
11-0112 was used in Flow cytometry/Cell sorting to identify a vascular inflammatory pathway that contributes to the development of cardiovascular disease.
Tue Dec 01 00:00:00 EST 2009
The novel role of tyrosine kinase inhibitor in the reversal of immune suppression and modulation of tumor microenvironment for immune-based cancer therapies.
Cancer research
Ozao-Choy J,Ma G,Kao J,Wang GX,Meseck M,Sung M,Schwartz M,Divino CM,Pan PY,Chen SH
11-0112 was used in Flow cytometry/Cell sorting to suggest that sunitinib can be used to reverse immune suppression and as a potentially useful adjunct for enhancing the efficacy of immune-based cancer therapy for advanced malignancies.
Sun Mar 15 00:00:00 EDT 2009
Immune depletion with cellular mobilization imparts immunoregulation and reverses autoimmune diabetes in nonobese diabetic mice.
Diabetes
Parker MJ,Xue S,Alexander JJ,Wasserfall CH,Campbell-Thompson ML,Battaglia M,Gregori S,Mathews CE,Song S,Troutt M,Eisenbeis S,Williams J,Schatz DA,Haller MJ,Atkinson MA
11-0112 was used in Flow cytometry/Cell sorting to investigate the use of ATG and GCSF in therapies to reverse overt hyperglycaemia in a diabetic mouse model.
Thu Oct 01 00:00:00 EDT 2009
Effector mechanisms of interleukin-17 in collagen-induced arthritis in the absence of interferon-gamma and counteraction by interferon-gamma.
Arthritis research & therapy
Kelchtermans H,Schurgers E,Geboes L,Mitera T,Van Damme J,Van Snick J,Uyttenhove C,Matthys P
11-0112 was used in Flow cytometry/Cell sorting to analyse the mechanisms of action of IL-17 in arthritis and the effect of IFN-gamma on those mechanisms.
Wed Dec 16 00:00:00 EST 2009
Naive mouse macrophages become activated following recognition of L5178Y lymphoma cells via concurrent ligation of CD40, NKG2D, and CD18 molecules.
Journal of immunology (Baltimore, Md. : 1950)
Buhtoiarov IN,Rakhmilevich AL,Lanier LL,Ranheim EA,Sondel PM
11-0112 was used in Flow cytometry/Cell sorting to investigate the mechanisms of tumour-macrophage interactions leading to macrophage activation, showing that activation follows ligation of CD40, NKG2D, and CD18 molecules.
Sun Feb 15 00:00:00 EST 2009
c-Myb is required for pro-B cell differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Fahl SP,Crittenden RB,Allman D,Bender TP
11-0112 was used in Flow cytometry/Cell sorting to demonstrate that c-Myb is absolutely required for the survival and differentiation of CD19(+) B-lineage cells.
Sun Nov 01 00:00:00 EDT 2009
IL-27 abrogates receptor activator of NF-kappa B ligand-mediated osteoclastogenesis of human granulocyte-macrophage colony-forming unit cells through STAT1-dependent inhibition of c-Fos.
Journal of immunology (Baltimore, Md. : 1950)
Furukawa M,Takaishi H,Takito J,Yoda M,Sakai S,Hikata T,Hakozaki A,Uchikawa S,Matsumoto M,Chiba K,Kimura T,Okada Y,Matsuo K,Yoshida H,Toyama Y
11-0112 was used in Flow cytometry/Cell sorting to investigate the direct effect of IL-27 on osteoclastogenesis and therefore its potential therapeutic use in inflammatory bone disease.
Sat Aug 15 00:00:00 EDT 2009
Hypercostimulation through 4-1BB distorts homeostasis of immune cells.
Journal of immunology (Baltimore, Md. : 1950)
Lee SW,Salek-Ardakani S,Mittler RS,Croft M
11-0112 was used in Flow cytometry/Cell sorting to investigate the potential side effects of immunotherapeutic strategies using Abs against costimulatory molecules.
Mon Jun 01 00:00:00 EDT 2009
Critical role of the interleukin-17/interleukin-17 receptor axis in regulating host susceptibility to respiratory infection with Chlamydia species.
Infection and immunity
Zhou X,Chen Q,Moore J,Kolls JK,Halperin S,Wang J
11-0112 was used in Flow cytometry/Cell sorting to demonstrate that Chlamydia stimulates IL-17/IL-17R-associated responses in Chlamydia-resistant and Chlamydia-susceptible mice.
Sun Nov 01 00:00:00 EDT 2009
DNAM-1 promotes activation of cytotoxic lymphocytes by nonprofessional antigen-presenting cells and tumors.
The Journal of experimental medicine
Gilfillan S,Chan CJ,Cella M,Haynes NM,Rapaport AS,Boles KS,Andrews DM,Smyth MJ,Colonna M
11-0112 was used in Flow cytometry/Cell sorting to study the promoted activation of cytotoxic lymphocytes by nonprofessional antigen-presenting cells and tumors by dnam-1.
Mon Dec 22 00:00:00 EST 2008
CD40 ligand promotes Mac-1 expression, leukocyte recruitment, and neointima formation after vascular injury.
The American journal of pathology
Li G,Sanders JM,Bevard MH,Sun Z,Chumley JW,Galkina EV,Ley K,Sarembock IJ
11-0112 was used in Flow cytometry/Cell sorting to study the function of CD40 ligand in neointima formation following vascular injury in an atherogenic animal model.
Tue Apr 01 00:00:00 EDT 2008
Polysialic acid, a glycan with highly restricted expression, is found on human and murine leukocytes and modulates immune responses.
Journal of immunology (Baltimore, Md. : 1950)
Drake PM,Nathan JK,Stock CM,Chang PV,Muench MO,Nakata D,Reader JR,Gip P,Golden KP,Weinhold B,Gerardy-Schahn R,Troy FA,Bertozzi CR
11-0112 was used in Flow cytometry/Cell sorting to investigate the expression and possible function of polysialic acid in the immune system.
Sat Nov 15 00:00:00 EST 2008
Polysialic acid, a glycan with highly restricted expression, is found on human and murine leukocytes and modulates immune responses.
Journal of immunology (Baltimore, Md. : 1950)
Drake PM,Nathan JK,Stock CM,Chang PV,Muench MO,Nakata D,Reader JR,Gip P,Golden KP,Weinhold B,Gerardy-Schahn R,Troy FA,Bertozzi CR
11-0112 was used in Flow cytometry/Cell sorting to investigate the expression and possible function of polysialic acid in the immune system.
Sat Nov 15 00:00:00 EST 2008
Runx proteins are involved in regulation of CD122, Ly49 family and IFN-gamma expression during NK cell differentiation.
International immunology
Ohno S,Sato T,Kohu K,Takeda K,Okumura K,Satake M,Habu S
11-0112 was used in Flow cytometry/Cell sorting to investigate the role of Runx family proteins in NK cells, showing that they are involved in regulation of CD122, Ly49 family and IFN-gamma expression during differentiation.
Tue Jan 01 00:00:00 EST 2008
Analysis of the IKKbeta/NF-kappaB signaling pathway during embryonic angiogenesis.
Developmental dynamics : an official publication of the American Association of Anatomists
Hou Y,Li F,Karin M,Ostrowski MC
11-0112 was used in Flow cytometry/Cell sorting to describe the IKKβ/NF-κB signalling pathway involved in embryonic angiogenesis, which Ikkβ locus disruption in foetal liver vasculature revealed to be responsible for regulation of hepatocyte proliferation and apoptosis, however not for hematopoiesis.
Wed Oct 01 00:00:00 EDT 2008
Disruption of CXCR4 enhances osteoclastogenesis and tumor growth in bone.
Proceedings of the National Academy of Sciences of the United States of America
Hirbe AC,Rubin J,Uluçkan O,Morgan EA,Eagleton MC,Prior JL,Piwnica-Worms D,Weilbaecher KN
11-0112 was used in Flow cytometry/Cell sorting to demonstrate that disruption of CXCR4 enhances osteoclastogenesis and suggest that inhibition of CXCR4 may enhance skeletal tumour burden.
Tue Aug 28 00:00:00 EDT 2007
Characterization and modeling of monocyte-derived macrophages after spinal cord injury.
Journal of neurochemistry
Longbrake EE,Lai W,Ankeny DP,Popovich PG
11-0112 was used in Flow cytometry/Cell sorting to characterise and model monocyte-derived macrophages after spinal cord injury.
Wed Aug 01 00:00:00 EDT 2007
Enhanced engraftment of hematopoietic stem/progenitor cells by the transient inhibition of an adaptor protein, Lnk.
Blood
Takizawa H,Kubo-Akashi C,Nobuhisa I,Kwon SM,Iseki M,Taga T,Takatsu K,Takaki S
11-0112 was used in Flow cytometry/Cell sorting to investigate the potential of Lnk for augmented engraftment of HSCs.
Sat Apr 01 00:00:00 EST 2006
Developmental switch of mouse hematopoietic stem cells from fetal to adult type occurs in bone marrow after birth.
Proceedings of the National Academy of Sciences of the United States of America
Kikuchi K,Kondo M
11-0112 was used in Flow cytometry/Cell sorting to demonstrate how foetal haematopoietic stem cells may acquire adult characteristics between 1 and 2 weeks after birth in mouse bone marrow.
Tue Nov 21 00:00:00 EST 2006
Increased expression of germinal center-associated nuclear protein RNA-primase is associated with lymphomagenesis.
Cancer research
Fujimura S,Xing Y,Takeya M,Yamashita Y,Ohshima K,Kuwahara K,Sakaguchi N
11-0112 was used in Flow cytometry/Cell sorting to study the role of GANP in lymphomagenesis.
Fri Jul 01 00:00:00 EDT 2005
Estrogen stimulates microglia and brain recovery from hypoxia-ischemia in normoglycemic but not diabetic female mice.
The Journal of clinical investigation
Zhang L,Nair A,Krady K,Corpe C,Bonneau RH,Simpson IA,Vannucci SJ
11-0112 was used in Flow cytometry/Cell sorting to describe antiapoptotic gene expression (bfl-1) in the brain with localization to microglia and macrophages.
Thu Jan 01 00:00:00 EST 2004
Mice lacking the type I interferon receptor are resistant to Listeria monocytogenes.
The Journal of experimental medicine
Auerbuch V,Brockstedt DG,Meyer-Morse N,O'Riordan M,Portnoy DA
11-0112 was used in Flow cytometry/Cell sorting to investigate the role of type I interferon receptors in viral defense using Listeria monocytogenes infection of mice as a model.
Mon Aug 16 00:00:00 EDT 2004
