Product References
6-Mercaptopurine potently inhibits recruitment of SHP2 by phosphorylated PD-1 to inhibit PD-1 signalling and enhance T cell function.
Immunology
Liu L,Lei Y,Zheng Z,Zhou X,Chen S,Zeng G,Yu L,Wang P,Chen L
45-0081-82 was used in Flow Cytometry to reveal a novel anti-tumour mechanism for the drug 6-mercaptopurine (6-MP) and suggests that 6-MP warrants further clinical evaluation for other tumour types.
Sun Oct 01 00:00:00 EDT 2023
Therapeutic potential of FLT4-targeting peptide in acute myeloid leukemia.
Cancer immunology, immunotherapy : CII
Lee JY,Park S,Han AR,Hwang HS,Kim HJ
45-0081-82 was used in Flow cytometry/Cell sorting to demonstrate the therapeutic value of functionally modulating lymphocytes using a peptide targeting FLT4 and proposed the development of advanced therapeutic approaches against AML by using immune cells.
Fri Sep 01 00:00:00 EDT 2023
Respiratory mucosal vaccination of peptide-poloxamine-DNA nanoparticles provides complete protection against lethal SARS-CoV-2 challenge.
Biomaterials
Sun S,Li E,Zhao G,Tang J,Zuo Q,Cai L,Xu C,Sui C,Ou Y,Liu C,Li H,Ding Y,Li C,Lu D,Zhang W,Luo P,Cheng P,Gao Y,Tu C,Pitard B,Rosenecker J,Wang B,Liu Y,Zou Q,Guan S
45-0081-82 was used in Flow cytometry/Cell sorting to indicate PP-sNp is a promising platform in mediating DNA vaccines to elicit all-around mucosal immunity against SARS-CoV-2.
Sun Jan 01 00:00:00 EST 2023
Meningeal lymphatic drainage promotes T cell responses against Toxoplasma gondii but is dispensable for parasite control in the brain.
eLife
Kovacs MA,Cowan MN,Babcock IW,Sibley LA,Still K,Batista SJ,Labuzan SA,Sethi I,Harris TH
45-0081-82 was used in Flow cytometry/Cell sorting to reveal that CNS lymphatic drainage supports the development of peripheral T cell responses against T. gondii but remains dispensable for immune protection of the brain.
Wed Dec 21 00:00:00 EST 2022
Maternal gut bacteria drive intestinal inflammation in offspring with neurodevelopmental disorders by altering the chromatin landscape of CD4+ T cells.
Immunity
Kim E,Paik D,Ramirez RN,Biggs DG,Park Y,Kwon HK,Choi GB,Huh JR
45-0081-82 was used in Flow cytometry/Cell sorting to investigate intestinal inflammation in children with autism spectrum disorders in response to maternal gut bacteria.
Tue Jan 11 00:00:00 EST 2022
Optimal target saturation of ligand-blocking anti-GITR antibody IBI37G5 dictates FcγR-independent GITR agonism and antitumor activity.
Cell reports. Medicine
Liu H,Wu W,Sun G,Chia T,Cao L,Liu X,Guan J,Fu F,Yao Y,Wu Z,Zhou S,Wang J,Lu J,Kuang Z,Wu M,He L,Shao Z,Wu D,Chen B,Xu W,Wang Z,He K
45-0081-82 was used in Flow cytometry/Cell sorting to propose an alternative dose-finding strategy that does not rely on the traditional maximal tolerated dose (MTD)-based paradigm but instead on utilizing the RO-function relations as biomarker to guide the clinical translation of GITR and similar co-stimulatory agonists.
Tue Jun 21 00:00:00 EDT 2022
In vivo genome-wide CRISPR screening identifies ZNF24 as a negative NF-κB modulator in lung cancer.
Cell & bioscience
Liu L,Lei Y,Chen W,Zhou Q,Zheng Z,Zeng G,Liu W,Feng P,Zhang Z,Yu L,Chen L
45-0081-82 was used in Flow cytometry/Cell sorting to reveal an important role played by loss of function of ZNF24 in lung tumorigenesis and shed new light in precision medicine for a portion of lung cancer patients.
Thu Dec 01 00:00:00 EST 2022
Malaria parasite heme biosynthesis promotes and griseofulvin protects against cerebral malaria in mice.
Nature communications
Chandana M,Anand A,Ghosh S,Das R,Beura S,Jena S,Suryawanshi AR,Padmanaban G,Nagaraj VA
45-0081-82 was used in Flow cytometry/Cell sorting to show heme synthesized in asexual stages promotes cerebral pathogenesis by enhancing hemozoin formation.
Tue Jul 12 00:00:00 EDT 2022
Double knockin mice show NF-κB trajectories in immune signaling and aging.
Cell reports
Rahman SMT,Aqdas M,Martin EW,Tomassoni Ardori F,Songkiatisak P,Oh KS,Uderhardt S,Yun S,Claybourne QC,McDevitt RA,Greco V,Germain RN,Tessarollo L,Sung MH
45-0081-82 was used in Flow cytometry/Cell sorting to demonstrate the power of these reporters in gaining deeper insights into NF-κB biology, with the spectral complementarity of the labeled NF-κB proteins enabling diverse applications.
Tue Nov 22 00:00:00 EST 2022
Low immunogenicity of malaria pre-erythrocytic stages can be overcome by vaccination.
EMBO molecular medicine
Müller K,Gibbins MP,Roberts M,Reyes-Sandoval A,Hill AVS,Draper SJ,Matuschewski K,Silvie O,Hafalla JCR
45-0081-82 was used in Flow Cytometry to test the impact of pre-erythrocytic malaria immunogenicity on the immune system response.
Fri Apr 09 00:00:00 EDT 2021
Generation of a Novel Oncolytic Vaccinia Virus Using the IHD-W Strain.
Human gene therapy
Shin J,Hong SO,Kim M,Lee H,Choi H,Kim J,Hong J,Kang H,Lee E,Lee S,Kong B,Kim M,Choi H,Kim S
45-0081 was used in Flow cytometry/Cell sorting to develope a novel oncolytic vaccinia virus with high potency and a favorable safety profile.
Sat May 01 00:00:00 EDT 2021
Establishment of monoclonal antibodies to evaluate the cellular immunity in a hamster model of L infantum infection.
Parasite immunology
Carvalho LM,de Brito RCF,Gusmão MR,de Oliveira Aguiar-Soares RD,Reis AB,Roatt BM
45-0081-82 was used in flow cytometry to propose the validation of some important commercially anti-mouse mAbs (CD4, TNF-α, IFN-γ and IL-10) and how this could be useful to evaluate a specific cellular immune response in Leishmania-infected hamster using flow cytometry experiments.
Thu Apr 01 00:00:00 EDT 2021
Anti-aging effects of a functional food via the action of gut microbiota and metabolites in aging mice.
Aging
Zhang J,Chen Z,Yu H,Lu Y,Yu W,Miao M,Shi H
45-0081-82 was used in Flow cytometry/Cell sorting to reveal the preventive effect of wushen on aging mice via a combined analysis of gut microbiome and metabolome.
Tue Apr 20 00:00:00 EDT 2021
Thymopentin treatment of murine premature ovarian failure via attenuation of immune cell activity and promotion of the BMP4/Smad9 signalling pathway.
International journal of medical sciences
Zhu X,Liu J,Pan H,Geng Z,Huang W,Liu T,Zhang B
45-0081-82 was used in Flow cytometry/Cell sorting to indicate somedifferences in gene transcription between the TP-5 intervention group and the control group.
Tue Mar 15 00:00:00 EDT 2022
Sequential Treatment of Bioresponsive Nanoparticles Elicits Antiangiogenesis and Apoptosis and Synergizes with a CD40 Agonist for Antitumor Immunity.
ACS nano
Ling X,Jiang X,Li Y,Han W,Rodriguez M,Xu Z,Lin W
45-0081-82 was used in flow cytometry to sequential delivery of antiangiogenic and chemotherapeutic agents with bioresponsive NPs activates tumor microenvironments and synergizes with CD40 agonist to regress transplanted tumors and inhibit disseminated tumors in a lung cancer mouse model.
Tue Jan 26 00:00:00 EST 2021
Macrophages Compensate for Loss of Protein Tyrosine Phosphatase N2 in Dendritic Cells to Protect from Elevated Colitis.
International journal of molecular sciences
Hering L,Katkeviciute E,Schwarzfischer M,Niechcial A,Riggs JB,Wawrzyniak M,Atrott K,van de Sande M,Lang S,Becher B,Rogler G,Scharl M,Spalinger MR
45-0081-82 was used in Flow cytometry/Cell sorting to investigate the dendritic cells-specific role of PTPN2 in the intestine during colitis development.
Fri Jun 25 00:00:00 EDT 2021
A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis.
Nature communications
Wang G,Xie L,Li B,Sang W,Yan J,Li J,Tian H,Li W,Zhang Z,Tian Y,Dai Y
45-0081-82 was used in Flow Cytometry to develop an assembly of exosome inhibitor and ferroptosis inducer via amphiphilic hyaluronic acid that enhances the response to PD-L1 checkpoint blockade.
Thu Sep 30 00:00:00 EDT 2021
Oxygen-Enriched Metal-Phenolic X-Ray Nanoprocessor for Cancer Radio-Radiodynamic Therapy in Combination with Checkpoint Blockade Immunotherapy.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Sang W,Xie L,Wang G,Li J,Zhang Z,Li B,Guo S,Deng CX,Dai Y
45-0081 was used in Flow cytometry/Cell sorting to presents a multifunctional metal-phenolic nanoplatform for efficient X-ray mediated RT-RDT in combination with immunotherapy and may provide a new therapeutic option for cancer treatment.
Mon Feb 01 00:00:00 EST 2021
ChAdOx1 nCoV-19 vaccine prevents SARS-CoV-2 pneumonia in rhesus macaques.
Nature
van Doremalen N,Lambe T,Spencer A,Belij-Rammerstorfer S,Purushotham JN,Port JR,Avanzato VA,Bushmaker T,Flaxman A,Ulaszewska M,Feldmann F,Allen ER,Sharpe H,Schulz J,Holbrook M,Okumura A,Meade-White K,Pérez-Pérez L,Edwards NJ,Wright D,Bissett C,Gilbride C,Williamson BN,Rosenke R,Long D,Ishwarbhai A,Kailath R,Rose L,Morris S,Powers C,Lovaglio J,Hanley PW,Scott D,Saturday G,de Wit E,Gilbert SC,Munster VJ
45-0081 was used in Flow cytometry/Cell sorting to demonstrate the efficacy of the adenovirus-vector-based vaccine ChAdOx1 nCoV-19 in rhesus macaques.
Thu Oct 01 00:00:00 EDT 2020
An Integrated Epigenomic and Transcriptomic Map of Mouse and Human αβ T Cell Development.
Immunity
Chopp LB,Gopalan V,Ciucci T,Ruchinskas A,Rae Z,Lagarde M,Gao Y,Li C,Bosticardo M,Pala F,Livak F,Kelly MC,Hannenhalli S,Bosselut R
45-0081-82 was used in Flow Cytometry to identify mouse and human αβ thymocyte developmental trajectories.
Tue Dec 15 00:00:00 EST 2020
An Integrated Epigenomic and Transcriptomic Map of Mouse and Human αβ T Cell Development.
Immunity
Chopp LB,Gopalan V,Ciucci T,Ruchinskas A,Rae Z,Lagarde M,Gao Y,Li C,Bosticardo M,Pala F,Livak F,Kelly MC,Hannenhalli S,Bosselut R
45-0081-82 was used in Flow Cytometry to identify mouse and human αβ thymocyte developmental trajectories.
Tue Dec 15 00:00:00 EST 2020
Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection.
Immunity
Bosteels C,Neyt K,Vanheerswynghels M,van Helden MJ,Sichien D,Debeuf N,De Prijck S,Bosteels V,Vandamme N,Martens L,Saeys Y,Louagie E,Lesage M,Williams DL,Tang SC,Mayer JU,Ronchese F,Scott CL,Hammad H,Guilliams M,Lambrecht BN
45-0081 was used in Flow cytometry/Cell sorting to show that monocyte-derived inflammatory DCs’’ are a mixture of monocyte-derived MCs that have little migratory and APC potential and bona fide pre-cDCderived, CD26-expressing inf-cDC2s that depend on Flt3L but not on GM-CSF.
Tue Jun 16 00:00:00 EDT 2020
BMI1 Inhibition Eliminates Residual Cancer Stem Cells after PD1 Blockade and Activates Antitumor Immunity to Prevent Metastasis and Relapse.
Cell stem cell
Jia L,Zhang W,Wang CY
45-0081-82 was used in Flow Cytometry to suggest that targeting BMI1 may enable immune checkpoint blockade to inhibit metastatic tumor growth and prevent tumor relapse by activating cell-intrinsic immunity, in addition to purging CSCs.
Thu Aug 06 00:00:00 EDT 2020
Splenic Capture and In Vivo Intracellular Biodegradation of Biological-Grade Graphene Oxide Sheets.
ACS nano
Newman L,Jasim DA,Prestat E,Lozano N,de Lazaro I,Nam Y,Assas BM,Pennock J,Haigh SJ,Bussy C,Kostarelos K
45-0081 was used in Flow cytometry/Cell sorting to interrogate the potential consequences of 2D graphene oxide (GO) nanosheets accumulation and the fate of the spleen-residing GO over a period of nine months.
Tue Aug 25 00:00:00 EDT 2020
Critical role of OX40 in drug-induced acute liver injury.
British journal of pharmacology
Zhang C,Jin H,Wang Y,Li C,Zhao X,Li Y,Shi W,Tian Y,Xu H,Tian D,Liu K,Jia J,Sun G,Zhang D
45-0081-82 was used in Flow Cytometry to show that OX40 is a key molecule that promotes both pro-inflammatory macrophage and CD4+ T-cell function, exacerbating paracetamol-induced liver injury.
Wed Jul 01 00:00:00 EDT 2020
MALT1 targeting suppresses CARD14-induced psoriatic dermatitis in mice.
EMBO reports
Van Nuffel E,Staal J,Baudelet G,Haegman M,Driege Y,Hochepied T,Afonina IS,Beyaert R
45-0081-82 was used in Flow Cytometry to investigate if inducible keratinocyte-specific expression of CARD14E138A in mice rapidly induces epidermal thickening and inflammation as well as increased expression of several genes associated with psoriasis in humans.
Fri Jul 03 00:00:00 EDT 2020
Astrocytes promote a protective immune response to brain Toxoplasma gondii infection via IL-33-ST2 signaling.
PLoS pathogens
Still KM,Batista SJ,O'Brien CA,Oyesola OO,Früh SP,Webb LM,Smirnov I,Kovacs MA,Cowan MN,Hayes NW,Thompson JA,Tait Wojno ED,Harris TH
45-0081 was used in Flow cytometry/Cell sorting to show that IL-33 is expressed by oligodendrocytes and astrocytes during T. gondii infection, is released locally into the cerebrospinal fluid of T. gondii-infected animals, and is required for control of infection.
Thu Oct 01 00:00:00 EDT 2020
NLRX1 is a key regulator of immune signaling during invasive pulmonary aspergillosis.
PLoS pathogens
Kastelberg B,Tubau-Juni N,Ayubi T,Leung A,Leber A,Hontecillas R,Bassaganya-Riera J,Kale SD
45-0081 was used in Flow cytometry/Cell sorting to point strongly towards the cell-specific and contextual function of Nlrx1 during invasive pulmonary aspergillosis and may lead to novel therapeutics to reduce Th2 responses by CD103+ DCs or heightened recruitment of neutrophils.
Tue Sep 01 00:00:00 EDT 2020
Role of dendritic cell-mediated immune response in oral homeostasis: A new mechanism of osteonecrosis of the jaw.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Elsayed R,Kurago Z,Cutler CW,Arce RM,Gerber J,Celis E,Sultan H,Elashiry M,Meghil M,Sun C,Auersvald CM,Awad ME,Zeitoun R,Elsayed R,Eldin M Elshikh M,Isales C,Elsalanty ME
45-0081-82 was used in Flow Cytometry to conclude that the mechanism of Zol-induced osteonecrosis of the jaw involves disruption of DC immune functions required to clear bacterial infection and activate T cell effector response.
Sat Feb 01 00:00:00 EST 2020
Role of dendritic cell-mediated immune response in oral homeostasis: A new mechanism of osteonecrosis of the jaw.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Elsayed R,Kurago Z,Cutler CW,Arce RM,Gerber J,Celis E,Sultan H,Elashiry M,Meghil M,Sun C,Auersvald CM,Awad ME,Zeitoun R,Elsayed R,Eldin M Elshikh M,Isales C,Elsalanty ME
45-0081-82 was used in Flow Cytometry to conclude that the mechanism of Zol-induced osteonecrosis of the jaw involves disruption of DC immune functions required to clear bacterial infection and activate T cell effector response.
Sat Feb 01 00:00:00 EST 2020
Loss of Setd4 delays radiation-induced thymic lymphoma in mice.
DNA repair
Feng X,Lu H,Yue J,Schneider N,Liu J,Denzin LK,Chan CS,De S,Shen Z
45-0081 was used in Flow cytometry/Cell sorting to report that conditional Setd4 deletion in adult mice significantly extended the survival of radiation-induced T-lymphoma.
Sat Feb 01 00:00:00 EST 2020
TIRC7 inhibits Th1 cells by upregulating the expression of CTLA‑4 and STAT3 in mice with acute graft‑versus‑host disease.
Oncology reports
Zhu F,Qiu T,Zhu S,Zhao K,Chen C,Qiao J,Pan B,Yan Z,Chen W,Liu Q,Wu Q,Cao J,Sang W,Zeng L,Sun H,Li Z,Xu K
45-0081 was used in Flow cytometry/Cell sorting to deepen the understanding of the pathogenesis of acute graft-versus-host disease (GVHD) and provide novel approaches for controlling acute GVHD.
Wed Jul 01 00:00:00 EDT 2020
Influenza NG-34 T cell conserved epitope adjuvanted with CAF01 as a possible influenza vaccine candidate.
Veterinary research
Sisteré-Oró M,Pedersen GK,Córdoba L,López-Serrano S,Christensen D,Darji A
45-0081 was used in Flow cytometry/Cell sorting to define the most efficient combination of antigen / adjuvant to combat influence virus infections.
Mon Apr 20 00:00:00 EDT 2020
Identification of atypical mitogen-activated protein kinase MAPK4 as a novel regulator in acute lung injury.
Cell & bioscience
Mao L,Zhou Y,Chen L,Hu L,Liu S,Zheng W,Zhao J,Guo M,Chen C,He Z,Xu L
45-0081-82 was used in Flow Cytometry to reveal an unknown role of atypical MAPKs member MAPK4 in the pathology of acute lung injury.
Sun Apr 17 00:00:00 EDT 2022
Comparative Analysis of Age-Related Changes in Lacrimal Glands and Meibomian Glands of a C57BL/6 Male Mouse Model.
International journal of molecular sciences
Yoon CH,Ryu JS,Hwang HS,Kim MK
45-0081 was used in Flow cytometry/Cell sorting to suggest that age-dependent DED in C57BL/6 mice is related to inflammation of the LGs, the development of MG atrophy, and oxidative stress in both glands.
Thu Jun 11 00:00:00 EDT 2020
A novel antibody targeting TIM-3 resulting in receptor internalization for cancer immunotherapy.
Antibody therapeutics
Kuang Z,Li L,Zhang P,Chen B,Wu M,Ni H,Yi S,Zou J,Liu J
45-0081 was used in Flow cytometry/Cell sorting to suggest that IBI104 is a promising blocking antibody for TIM-3-mediated suppressive signaling and can serve as effective cancer immunotherapy, especially in combination with anti-PD1.
Tue Dec 01 00:00:00 EST 2020
Protein Tyrosine Phosphatase Non-Receptor Type 2 Function in Dendritic Cells Is Crucial to Maintain Tissue Tolerance.
Frontiers in immunology
Hering L,Katkeviciute E,Schwarzfischer M,Busenhart P,Gottier C,Mrdjen D,Komuczki J,Wawrzyniak M,Lang S,Atrott K,Becher B,Rogler G,Scharl M,Spalinger MR
45-0081 was used in Flow cytometry/Cell sorting to show dendritic cell PTPN2 might explain the central role for PTPN2 in the immune system to maintain immune tolerance.
Mon Apr 12 00:00:00 EDT 2021
Small Molecule Enhancers of Endosome-to-Cytosol Import Augment Anti-tumor Immunity.
Cell reports
Kozik P,Gros M,Itzhak DN,Joannas L,Heurtebise-Chrétien S,Krawczyk PA,Rodríguez-Silvestre P,Alloatti A,Magalhaes JG,Del Nery E,Borner GHH,Amigorena S
45-0081 was used in Flow cytometry/Cell sorting to identify 37 enhancers of antigen import from endolysosomes into the cytosol from screening 700 US Food and Drug Administration (FDA)-approved drugs and reveal their mechanism of action.
Tue Jul 14 00:00:00 EDT 2020
Prodrug-Loaded Zirconium Carbide Nanosheets as a Novel Biophotonic Nanoplatform for Effective Treatment of Cancer.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Liu Q,Xie Z,Qiu M,Shim I,Yang Y,Xie S,Yang Q,Wang D,Chen S,Fan T,Ding B,Guo Z,Adah D,Yao X,Zhang Y,Wu H,Wu Z,Wei C,Wang H,Kim HS,Zou Q,Yan Q,Cai Z,Kim JS,Liu LP,Zhang H,Cao Y
45-0081-82 was used in Flow Cytometry to unravel a promising biphotonic strategy for precision treatment of cancer.
Tue Dec 01 00:00:00 EST 2020
A Thpok-Directed Transcriptional Circuitry Promotes Bcl6 and Maf Expression to Orchestrate T Follicular Helper Differentiation.
Immunity
Vacchio MS,Ciucci T,Gao Y,Watanabe M,Balmaceno-Criss M,McGinty MT,Huang A,Xiao Q,McConkey C,Zhao Y,Shetty J,Tran B,Pepper M,Vahedi G,Jenkins MK,McGavern DB,Bosselut R
45-0081-82 was used in Flow Cytometry to identify a transcriptional program that links the CD4+ lineage with Tfh differentiation, a limiting factor for efficient B cell responses.
Tue Sep 17 00:00:00 EDT 2019
Expansion of Bacteriophages Is Linked to Aggravated Intestinal Inflammation and Colitis.
Cell host & microbe
Gogokhia L,Buhrke K,Bell R,Hoffman B,Brown DG,Hanke-Gogokhia C,Ajami NJ,Wong MC,Ghazaryan A,Valentine JF,Porter N,Martens E,O'Connell R,Jacob V,Scherl E,Crawford C,Stephens WZ,Casjens SR,Longman RS,Round JL
45-0081 was used in Flow cytometry/Cell sorting to indicate that bacteriophages can alter mucosal immunity to impact mammalian health.
Wed Feb 13 00:00:00 EST 2019
The ROP16III-dependent early immune response determines the subacute CNS immune response and type III Toxoplasma gondii survival.
PLoS pathogens
Tuladhar S,Kochanowsky JA,Bhaskara A,Ghotmi Y,Chandrasekaran S,Koshy AA
45-0081-82 was used in Flow Cytometry to show ROP16III in type III strain Toxoplasma gondii can influence the subacute CNS immune response and mediate parasitic survival and persistence.
Tue Oct 01 00:00:00 EDT 2019
T Lymphocytes Attenuate Dermal Scarring by Regulating Inflammation, Neovascularization, and Extracellular Matrix Remodeling.
Advances in wound care
Wang X,Balaji S,Steen EH,Li H,Rae MM,Blum AJ,Miao Q,Butte MJ,Bollyky PL,Keswani SG
45-0081 was used in Flow cytometry/Cell sorting to implicate adaptive immunity in the regulation of scarring phenotypes.
Fri Nov 01 00:00:00 EDT 2019
MDM2 inhibitor APG-115 synergizes with PD-1 blockade through enhancing antitumor immunity in the tumor microenvironment.
Journal for immunotherapy of cancer
Fang DD,Tang Q,Kong Y,Wang Q,Gu J,Fang X,Zou P,Rong T,Wang J,Yang D,Zhai Y
45-0081-82 was used in Flow cytometry/Cell sorting to demonstrate that p53 activation mediated by APG-115 promotes antitumor immunity in the tumor microenvironment (TME) regardless of the Trp53 status of tumors per se.
Thu Nov 28 00:00:00 EST 2019
Checkpoint blockade and nanosonosensitizer-augmented noninvasive sonodynamic therapy combination reduces tumour growth and metastases in mice.
Nature communications
Yue W,Chen L,Yu L,Zhou B,Yin H,Ren W,Liu C,Guo L,Zhang Y,Sun L,Zhang K,Xu H,Chen Y
Thu May 02 00:00:00 EDT 2019
Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR.
Nature communications
Zhu H,Bhatt B,Sivaprakasam S,Cai Y,Liu S,Kodeboyina SK,Patel N,Savage NM,Sharma A,Kaufman RJ,Li H,Singh N
45-0081 was used in Flow cytometry/Cell sorting to demonstrate the promotion of plasma cell development and function by the unfolded protein response pathway is regulated by Ufbp1.
Wed Mar 06 00:00:00 EST 2019
Virus-Induced Interferon-γ Causes Insulin Resistance in Skeletal Muscle and Derails Glycemic Control in Obesity.
Immunity
Šestan M,Marinović S,Kavazović I,Cekinović Đ,Wueest S,Turk Wensveen T,Brizić I,Jonjić S,Konrad D,Wensveen FM,Polić B
45-0081 was used in Flow cytometry/Cell sorting to study how viral infection effects insulin resistance.
Tue Jul 17 00:00:00 EDT 2018
Quiescent Tissue Stem Cells Evade Immune Surveillance.
Immunity
Agudo J,Park ES,Rose SA,Alibo E,Sweeney R,Dhainaut M,Kobayashi KS,Sachidanandam R,Baccarini A,Merad M,Brown BD
45-0081 was used in Flow cytometry/Cell sorting to identify a link between stem cell quiescence, antigen presentation, and immune evasion.
Tue Feb 20 00:00:00 EST 2018
Photochemical Internalization of Peptide Antigens Provides a Novel Strategy to Realize Therapeutic Cancer Vaccination.
Frontiers in immunology
Haug M,Brede G,Håkerud M,Nedberg AG,Gederaas OA,Flo TH,Edwards VT,Selbo PK,Høgset A,Halaas Ø
45-0081 was used in Flow cytometry/Cell sorting to study the ability of photochemical internalisation as a vaccination technology to induce priming of cancer-specific CD8+ cytotoxic T lymphocytes.
Mon Jun 24 00:00:00 EDT 2019
Murine CMV induces type 1 IFN that impairs differentiation of MDSCs critical for transplantation tolerance.
Blood advances
Dangi A,Zhang L,Zhang X,Luo X
45-0081 was used in Flow cytometry/Cell sorting to provide a solid foundation for seeking effective therapies for promoting transplantation tolerance in settings of CMV infection.
Tue Mar 27 00:00:00 EDT 2018
Human Interleukin-32γ Plays a Protective Role in an Experimental Model of Visceral Leishmaniasis in Mice.
Infection and immunity
Gomes RS,Silva MVT,Dos Santos JC,van Linge C,Reis JM,Teixeira MM,Pinto SA,Dorta ML,Bai X,Chan ED,Dinarello CA,Oliveira MAP,Joosten LAB,Ribeiro-Dias F
45-0081 was used in Flow cytometry/Cell sorting to study the role of interleukin-32γ in potentiating the Th1/Th17 immune response during experimental visceral leishmaniasis.
Tue May 01 00:00:00 EDT 2018
Targeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution.
Nature communications
Efremova M,Rieder D,Klepsch V,Charoentong P,Finotello F,Hackl H,Hermann-Kleiter N,Löwer M,Baier G,Krogsdam A,Trajanoski Z
45-0081 was used in Flow cytometry/Cell sorting to demonstrate that neutral evolution is another force that contributes to sculpting the tumor and that checkpoint blockade effectively enforces T-cell-dependent immunoselective pressure.
Tue Jan 02 00:00:00 EST 2018
Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation.
Nature communications
Bonacina F,Coe D,Wang G,Longhi MP,Baragetti A,Moregola A,Garlaschelli K,Uboldi P,Pellegatta F,Grigore L,Da Dalt L,Annoni A,Gregori S,Xiao Q,Caruso D,Mitro N,Catapano AL,Marelli-Berg FM,Norata GD
45-0081 was used in Flow cytometry/Cell sorting to show that apolipoprotein E deficiency leads to the accumulation of cholesterol in the cell membrane of dendritic cells, resulting in enhanced MHC-II-dependent antigen presentation and CD4+ T-cell activation.
Mon Aug 06 00:00:00 EDT 2018
Notch Signaling Facilitates In Vitro Generation of Cross-Presenting Classical Dendritic Cells.
Cell reports
Kirkling ME,Cytlak U,Lau CM,Lewis KL,Resteu A,Khodadadi-Jamayran A,Siebel CW,Salmon H,Merad M,Tsirigos A,Collin M,Bigley V,Reizis B
45-0081 was used in Flow cytometry/Cell sorting to examine the role of Notch signalling in the in vitro generation of classical dendritic cells.
Tue Jun 19 00:00:00 EDT 2018
Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis.
Nature communications
Kim DH,Park HJ,Lim S,Koo JH,Lee HG,Choi JO,Oh JH,Ha SJ,Kang MJ,Lee CM,Lee CG,Elias JA,Choi JM
45-0081 was used in Flow cytometry/Cell sorting to demonstrate that Chitinase-3-like-1 is a regulator of Th1 and CTL, which could be a potential anti-tumor immunity target.
Mon Feb 05 00:00:00 EST 2018
Nuclear receptor NR2F6 inhibition potentiates responses to PD-L1/PD-1 cancer immune checkpoint blockade.
Nature communications
Klepsch V,Hermann-Kleiter N,Do-Dinh P,Jakic B,Offermann A,Efremova M,Sopper S,Rieder D,Krogsdam A,Gamerith G,Perner S,Tzankov A,Trajanoski Z,Wolf D,Baier G
45-0081 was used in Flow cytometry/Cell sorting to define NR2F6 as an intracellular immune checkpoint with potential as a therapeutic target in cancer treatment.
Wed Apr 18 00:00:00 EDT 2018
Regulation of Lymphatic GM-CSF Expression by the E3 Ubiquitin Ligase Cbl-b.
Frontiers in immunology
Peer S,Cappellano G,Hermann-Kleiter N,Albrecht-Schgoer K,Hinterleitner R,Baier G,Gruber T
45-0081 was used in Flow cytometry/Cell sorting to study the effects of Cblb knockout in mice.
Tue Sep 24 00:00:00 EDT 2019
BCL-2 levels do not predict azathioprine treatment response in inflammatory bowel disease, but inhibition induces lymphocyte apoptosis and ameliorates colitis in mice.
Clinical and experimental immunology
Weder B,Mozaffari M,Biedermann L,Mamie C,Moncsek A,Wang L,Clarke SH,Rogler G,McRae BL,Graff CL,Ruiz PA,Hausmann M
45-0081-82 was used in flow cytometry to investigate whether the BCL-2 family expression pattern could be used to predict treatment response to AZA and determined whether BCL-2 inhibitor A-1211212 effectively diminishes lymphocytes and ameliorates inflammation in a model of colitis.
Sat Sep 01 00:00:00 EDT 2018
Limited Foxp3+ Regulatory T Cells Response During Acute Trypanosoma cruzi Infection Is Required to Allow the Emergence of Robust Parasite-Specific CD8+ T Cell Immunity.
Frontiers in immunology
Araujo Furlan CL,Tosello Boari J,Rodriguez C,Canale FP,Fiocca Vernengo F,Boccardo S,Beccaria CG,Adoue V,Joffre O,Gruppi A,Montes CL,Acosta Rodriguez EV
45-0081 was used in Flow cytometry/Cell sorting to study the role of regulatory T cells during Trypanosoma cruzi infection.
Thu Sep 26 00:00:00 EDT 2019
Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring.
Nature
Kim S,Kim H,Yim YS,Ha S,Atarashi K,Tan TG,Longman RS,Honda K,Littman DR,Choi GB,Huh JR
45-0081 was used in Flow cytometry/Cell sorting to suggest that defined gut commensal bacteria with a propensity to induce TH17 cells may increase the risk of neurodevelopmental disorders in the offspring of pregnant mothers undergoing immune system activation owing to infections or autoinflammatory syndromes.
Thu Sep 28 00:00:00 EDT 2017
T-Cell Mineralocorticoid Receptor Controls Blood Pressure by Regulating Interferon-Gamma.
Circulation research
Sun XN,Li C,Liu Y,Du LJ,Zeng MR,Zheng XJ,Zhang WC,Liu Y,Zhu M,Kong D,Zhou L,Lu L,Shen ZX,Yi Y,Du L,Qin M,Liu X,Hua Z,Sun S,Yin H,Zhou B,Yu Y,Zhang Z,Duan SZ
45-0081 was used in Flow cytometry/Cell sorting to determine the role of T-cell mineralocorticoid receptor in blood pressure regulation and explore the mechanism.
Fri May 12 00:00:00 EDT 2017
Critical role for Sec22b-dependent antigen cross-presentation in antitumor immunity.
The Journal of experimental medicine
Alloatti A,Rookhuizen DC,Joannas L,Carpier JM,Iborra S,Magalhaes JG,Yatim N,Kozik P,Sancho D,Albert ML,Amigorena S
45-0081 was used in Flow cytometry/Cell sorting to determine that Sec22b-dependent cross-presentation in dendritic cells is required to initiate CD8 T cell responses to dead cells, and induce effective anti-tumour immune responses during anti-PD-1 treatment.
Mon Aug 07 00:00:00 EDT 2017
DC subset-specific induction of T cell responses upon antigen uptake via Fcγ receptors in vivo.
The Journal of experimental medicine
Lehmann CHK,Baranska A,Heidkamp GF,Heger L,Neubert K,Lühr JJ,Hoffmann A,Reimer KC,Brückner C,Beck S,Seeling M,Kießling M,Soulat D,Krug AB,Ravetch JV,Leusen JHW,Nimmerjahn F,Dudziak D
45-0081 was used in Flow cytometry/Cell sorting to suggest that targeting antigens to FcγRs on DCs may be a promising approach to raise immunogenic or tolerogenic T cell responses to antigens of choice.
Mon May 01 00:00:00 EDT 2017
Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy.
Brain : a journal of neurology
Laurent C,Dorothée G,Hunot S,Martin E,Monnet Y,Duchamp M,Dong Y,Légeron FP,Leboucher A,Burnouf S,Faivre E,Carvalho K,Caillierez R,Zommer N,Demeyer D,Jouy N,Sazdovitch V,Schraen-Maschke S,Delarasse C,Buée L,Blum D
45-0081 was used in Flow cytometry/Cell sorting to elucidate the contribution of brain immune cells in tau-driven pathophysiology in Alzheimer's.
Sun Jan 01 00:00:00 EST 2017
The autophagy machinery restrains iNKT cell activation through CD1D1 internalization.
Autophagy
Keller CW,Loi M,Ewert S,Quast I,Theiler R,Gannagé M,Münz C,De Libero G,Freigang S,Lünemann JD
45-0081-82 was used in Flow Cytometry to indicate that the autophagic machinery assists in the recruitment of AP2 to CD1D1 molecules resulting in attenuated iNKT cell activation, in contrast to the supporting role of macroautophagy in CD4+ T cell stimulation.
Sat Jun 03 00:00:00 EDT 2017
Oncolytic Adenovirus and Tumor-Targeting Immune Modulatory Therapy Improve Autologous Cancer Vaccination.
Cancer research
Jiang H,Rivera-Molina Y,Gomez-Manzano C,Clise-Dwyer K,Bover L,Vence LM,Yuan Y,Lang FF,Toniatti C,Hossain MB,Fueyo J
45-0081 was used in Flow cytometry/Cell sorting to demonstrate that combining an oncolytic virus with tumor-targeting immune checkpoint modulators elicits potent in situ autologous cancer vaccination, resulting in an efficacious, tumor-specific, and long-lasting therapeutic effect.
Sat Jul 15 00:00:00 EDT 2017
Retinoic Acid Regulates Immune Responses by Promoting IL-22 and Modulating S100 Proteins in Viral Hepatitis.
Journal of immunology (Baltimore, Md. : 1950)
Jie Z,Liang Y,Yi P,Tang H,Soong L,Cong Y,Zhang K,Sun J
45-0081 was used in Flow cytometry/Cell sorting to determine the role of retinoic acid in IL-22 production during hepatitis infection.
Mon May 01 00:00:00 EDT 2017
Cblb-deficient T cells are less susceptible to PD-L1-mediated inhibition.
Oncotarget
Peer S,Baier G,Gruber T
45-0081 was used in Flow cytometry/Cell sorting to show that Cblb-/- T cells are less susceptible to PD-L1-mediated suppression of T cell proliferation and IFNγ secretion.
Tue Jun 27 00:00:00 EDT 2017
Dengue vaccine-induced CD8+ T cell immunity confers protection in the context of enhancing, interfering maternal antibodies.
JCI insight
Lam JH,Chua YL,Lee PX,Martínez Gómez JM,Ooi EE,Alonso S
45-0081 was used in Flow cytometry/Cell sorting to establish the development of dengue vaccine candidates that induce protective CD8+ T cells despite the presence of enhancing, interfering maternal antibodies.
Thu Dec 21 00:00:00 EST 2017
Evaluation of Plasmodium vivax Cell-Traversal Protein for Ookinetes and Sporozoites as a Preerythrocytic P. vivax Vaccine.
Clinical and vaccine immunology : CVI
Alves E,Salman AM,Leoratti F,Lopez-Camacho C,Viveros-Sandoval ME,Lall A,El-Turabi A,Bachmann MF,Hill AV,Janse CJ,Khan SM,Reyes-Sandoval A
45-0081 was used in Flow cytometry/Cell sorting to generate vaccine platforms targeting a malarial parasite protein and assess them for protective efficacy.
Sat Apr 01 00:00:00 EDT 2017
Antitumor adaptive immunity remains intact following inhibition of autophagy and antimalarial treatment.
The Journal of clinical investigation
Starobinets H,Ye J,Broz M,Barry K,Goldsmith J,Marsh T,Rostker F,Krummel M,Debnath J
45-0081 was used in Flow cytometry/Cell sorting to evaluate how autophagy inhibition impacts the antitumor immune response in immune-competent mouse models of melanoma and mammary cancer.
Thu Dec 01 00:00:00 EST 2016
Development of Th17-Associated Interstitial Kidney Inflammation in Lupus-Prone Mice Lacking the Gene Encoding STAT-1.
Arthritis & rheumatology (Hoboken, N.J.)
Yiu G,Rasmussen TK,Ajami B,Haddon DJ,Chu AD,Tangsombatvisit S,Haynes WA,Diep V,Steinman L,Faix J,Utz PJ
45-0081 was used in Flow cytometry/Cell sorting to investigate the roles of the type I and type II IFN signaling components in systemic Lupus Erythematosus, showing the development of Th17-associated interstitial kidney inflammation in mice lacking STAT-1.
Sun May 01 00:00:00 EDT 2016
Radiotherapy Combined with Novel STING-Targeting Oligonucleotides Results in Regression of Established Tumors.
Cancer research
Baird JR,Friedman D,Cottam B,Dubensky TW,Kanne DB,Bambina S,Bahjat K,Crittenden MR,Gough MJ
45-0081 was used in Immunofluorescence to demonstrate that when combined with novel STING agonists, radiation therapy generates T-cell immunity for disease control.
Fri Jan 01 00:00:00 EST 2016
Protein Translation Activity: A New Measure of Host Immune Cell Activation.
Journal of immunology (Baltimore, Md. : 1950)
Seedhom MO,Hickman HD,Wei J,David A,Yewdell JW
45-0081 was used in Flow cytometry/Cell sorting to describe the in vivo ribopuromycylation method.
Mon Aug 15 00:00:00 EDT 2016
Evaluation of Cross-presentation in Bone Marrow-derived Dendritic Cells in vitro and Splenic Dendritic Cells ex vivo Using Antigen-coated Beads.
Bio-protocol
Alloatti A,Kotsias F,Hoffmann E,Amigorena S
45-0081 was used in Flow cytometry/Cell sorting to develop a protocol for evaluating antigen cross-presentation by dendritic cells, both in vivo and ex vivo.
Sun Nov 20 00:00:00 EST 2016
Cell Type Preference of a Novel Human Derived Cell-Permeable Peptide dNP2 and TAT in Murine Splenic Immune Cells.
PloS one
Lim S,Lee JA,Koo JH,Kang TG,Ha SJ,Choi JM
45-0081 was used in Flow cytometry/Cell sorting to demonstrate that uptake of cell-permeable peptides differs between phagocytic and non-phagocytic immune cells.
Tue Jul 11 00:00:00 EDT 2017
Absence of apolipoprotein E protects mice from cerebral malaria.
Scientific reports
Kassa FA,Van Den Ham K,Rainone A,Fournier S,Boilard E,Olivier M
45-0081 was used in Flow cytometry/Cell sorting to reveal a unique biomarker, apolipoprotein E, for cerebral malaria.
Tue Sep 20 00:00:00 EDT 2016
Streptomycin treatment alters the intestinal microbiome, pulmonary T cell profile and airway hyperresponsiveness in a cystic fibrosis mouse model.
Scientific reports
Bazett M,Bergeron ME,Haston CK
45-0081 was used in Flow cytometry/Cell sorting to reveal a potential intestinal microbiome influence on lung response in BALB/c Cftr(tm1UNC) mice.
Tue Jan 12 00:00:00 EST 2016
Antigen presenting cell abnormalities in the Cln3(-/-) mouse model of juvenile neuronal ceroid lipofuscinosis.
Biochimica et biophysica acta
Hersrud SL,Kovács AD,Pearce DA
45-0081 was used in Flow cytometry/Cell sorting to show that CLN3 deficiency alters antigen presenting cells, which can contribute to the autoimmune response in juvenile neuronal ceroid lipofuscinosis.
Fri Jul 01 00:00:00 EDT 2016
Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy.
Nature communications
Chen Q,Xu L,Liang C,Wang C,Peng R,Liu Z
45-0081 was used in Immunohistochemistry to investigate the use of immuneadjuvant nanoparticles for photothermal tumour ablation in mice and their potential for cancer immunotherapy.
Fri Oct 21 00:00:00 EDT 2016
GFP-specific CD8 T cells enable targeted cell depletion and visualization of T-cell interactions.
Nature biotechnology
Agudo J,Ruzo A,Park ES,Sweeney R,Kana V,Wu M,Zhao Y,Egli D,Merad M,Brown BD
45-0081 was used in Flow cytometry/Cell sorting to generate and use GFP-specific CD8 T cells to investigate less understood cell types and their interactions with the immune system.
Tue Dec 01 00:00:00 EST 2015
IKKβ acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis.
The Journal of experimental medicine
Pallangyo CK,Ziegler PK,Greten FR
45-0081 was used in Flow cytometry/Cell sorting to highlight an unexpected tumor suppressive function of IKKβ/NF-κB in CAFs linked to HGF release.
Mon Dec 14 00:00:00 EST 2015
Laser mimicking mosquito bites for skin delivery of malaria sporozoite vaccines.
Journal of controlled release : official journal of the Controlled Release Society
Zhou C,Chen X,Zhang Q,Wang J,Wu MX
45-0081 was used in Flow cytometry/Cell sorting to report in a murine model that intradermal inoculation of radiation-attenuated sporozoites into laser-illuminated skin provides almost full protection against malarial infection.
Tue Apr 28 00:00:00 EDT 2015
Quantitative and Qualitative Analysis of Bone Marrow CD8(+) T Cells from Different Bones Uncovers a Major Contribution of the Bone Marrow in the Vertebrae.
Frontiers in immunology
Geerman S,Hickson S,Brasser G,Pascutti MF,Nolte MA
45-0081 was used in Flow cytometry/Cell sorting to suggest that in respect to CD8(+) T cells, BM harvested from a single bone is a fair reflection of the rest of the BM present in the murine body.
Thu Jan 21 00:00:00 EST 2016
TAGLN2 regulates T cell activation by stabilizing the actin cytoskeleton at the immunological synapse.
The Journal of cell biology
Na BR,Kim HR,Piragyte I,Oh HM,Kwon MS,Akber U,Lee HS,Park DS,Song WK,Park ZY,Im SH,Rho MC,Hyun YM,Kim M,Jun CD
45-0081 was used in Flow cytometry/Cell sorting to reveal a novel function of TAGLN2 in enhancing T cell responses.
Mon Apr 13 00:00:00 EDT 2015
Premature thymic involution is independent of structural plasticity of the thymic stroma.
European journal of immunology
Franckaert D,Schlenner SM,Heirman N,Gill J,Skogberg G,Ekwall O,Put K,Linterman MA,Dooley J,Liston A
45-0081 was used in Flow cytometry/Cell sorting to investigate thymic involution in FVB/N mice, showing that disruption of the epithelial-endothelial relationship and a progressive loss of pro-T cells precedes involution, and loss of pro-T cells is sufficient to drive premature involution, suggesting that pro-T cells are the main driver of involution.
Fri May 01 00:00:00 EDT 2015
CD8+ T Cells Can Mediate Short-Term Protection against Heterotypic Dengue Virus Reinfection in Mice.
Journal of virology
Zellweger RM,Tang WW,Eddy WE,King K,Sanchez MC,Shresta S
45-0081 was used in Flow cytometry/Cell sorting to investigate short-term protection against heterotypic Dengue virus reinfection in mice mediated by CD8+ T Cells.
Mon Jun 01 00:00:00 EDT 2015
Filter-Dense Multicolor Microscopy.
PloS one
Kijani S,Yrlid U,Heyden M,Levin M,Borén J,Fogelstrand P
45-0081 was used in Immunofluorescence to demonstrate an enhanced multi-fluorescence setup based on condensed filter sets that significantly increases the number of channels in multicolour microscopy.
Tue Jan 19 00:00:00 EST 2016
Iron prevents the development of experimental cerebral malaria by attenuating CXCR3-mediated T cell chemotaxis.
PloS one
Van Den Ham KM,Shio MT,Rainone A,Fournier S,Krawczyk CM,Olivier M
45-0081 was used in Flow cytometry/Cell sorting to determine that the incidence of ECM was markedly reduced in mice treated with iron dextran.
Thu Jan 21 00:00:00 EST 2016
The miR-126-VEGFR2 axis controls the innate response to pathogen-associated nucleic acids.
Nature immunology
Agudo J,Ruzo A,Tung N,Salmon H,Leboeuf M,Hashimoto D,Becker C,Garrett-Sinha LA,Baccarini A,Merad M,Brown BD
45-0081 was used in Flow cytometry/Cell sorting to identify the miR-126-VEGFR2 axis as an important regulator of the innate response that operates through multiscale control of pDCs.
Wed Jan 01 00:00:00 EST 2014
Engagement of the ICOS pathway markedly enhances efficacy of CTLA-4 blockade in cancer immunotherapy.
The Journal of experimental medicine
Fan X,Quezada SA,Sepulveda MA,Sharma P,Allison JP
45-0081 was used in Flow cytometry/Cell sorting to investigate the role of the ICOS pathway in increasing the efficiency of the CTLA-4 blockade in cancer immunotherapy.
Mon Apr 07 00:00:00 EDT 2014
The Alarmin HMGN1 contributes to antitumor immunity and is a potent immunoadjuvant.
Cancer research
Wei F,Yang D,Tewary P,Li Y,Li S,Chen X,Howard OM,Bustin M,Oppenheim JJ
45-0081 was used in Flow cytometry/Cell sorting to demonstrate the alarmin HMGN1 contributes to antitumor immunity and may offer an effective adjuvant to heighten responses to cancer vaccines.
Sat Nov 01 00:00:00 EDT 2014
Large T Antigen-Specific Cytotoxic T Cells Protect Against Dendritic Cell Tumors through Perforin-Mediated Mechanisms Independent of CD4 T Cell Help.
Frontiers in immunology
Duval A,Fuertes Marraco SA,Schwitter D,Leuenberger L,Acha-Orbea H
45-0081 was used in Flow cytometry/Cell sorting to observe that after transfer into syngeneic C57BL/6 mice, MuTuDC lines were quickly rejected.
Thu Aug 07 00:00:00 EDT 2014
High-frequency vaccine-induced CD8⁺ T cells specific for an epitope naturally processed during infection with Mycobacterium tuberculosis do not confer protection.
European journal of immunology
Lindenstrøm T,Aagaard C,Christensen D,Agger EM,Andersen P
45-0081 was used in Flow cytometry/Cell sorting to study the role of CD8 T cells in resistance to mycobacterial infections.
Sun Jun 01 00:00:00 EDT 2014
CD8+ T cells prevent antigen-induced antibody-dependent enhancement of dengue disease in mice.
Journal of immunology (Baltimore, Md. : 1950)
Zellweger RM,Eddy WE,Tang WW,Miller R,Shresta S
45-0081 was used in Flow cytometry/Cell sorting to investigate how CD8(+) T cell responses influence the outcome of antibody-mediated severe dengue disease.
Wed Oct 15 00:00:00 EDT 2014
Preemptive donor apoptotic cell infusions induce IFN-γ-producing myeloid-derived suppressor cells for cardiac allograft protection.
Journal of immunology (Baltimore, Md. : 1950)
Bryant J,Lerret NM,Wang JJ,Kang HK,Tasch J,Zhang Z,Luo X
45-0081 was used in Flow cytometry/Cell sorting to investigate the role of MDSCs in the graft protection provided by ECDI-SPs, showing that preemptive donor apoptotic cell infusions induce IFN-γ-producing MDSCs.
Sun Jun 15 00:00:00 EDT 2014
Intrahepatic innate lymphoid cells secrete IL-17A and IL-17F that are crucial for T cell priming in viral infection.
Journal of immunology (Baltimore, Md. : 1950)
Jie Z,Liang Y,Hou L,Dong C,Iwakura Y,Soong L,Cong Y,Sun J
45-0081 was used in Flow cytometry/Cell sorting to investigate the source and regulation of the IL-17 surge in the liver microenvironment that occurs early in the response to viral infection.
Tue Apr 01 00:00:00 EDT 2014
GM-CSF but not IL-17 is critical for the development of severe interstitial lung disease in SKG mice.
Journal of immunology (Baltimore, Md. : 1950)
Shiomi A,Usui T,Ishikawa Y,Shimizu M,Murakami K,Mimori T
45-0081 was used in Flow cytometry/Cell sorting to investigate the importance of GM-CSF in the development of severe interstitial lung disease.
Tue Jul 15 00:00:00 EDT 2014
Gene deletions in Mycobacterium bovis BCG stimulate increased CD8+ T cell responses.
Infection and immunity
Panas MW,Sixsmith JD,White K,Korioth-Schmitz B,Shields ST,Moy BT,Lee S,Schmitz JE,Jacobs WR,Porcelli SA,Haynes BF,Letvin NL,Gillard GO
45-0081 was used in Flow cytometry/Cell sorting to discover the immunosuppressive effects of several mycobacterial genes.
Mon Dec 01 00:00:00 EST 2014
Antigen capture and archiving by lymphatic endothelial cells following vaccination or viral infection.
Nature communications
Tamburini BA,Burchill MA,Kedl RM
45-0081 was used in Flow cytometry/Cell sorting to better understand the role for persisting antigen in both vaccine and infectious settings, which could impact future vaccination strategies.
Fri Jun 06 00:00:00 EDT 2014
Prevention or early cure of type 1 diabetes by intranasal administration of gliadin in NOD mice.
PloS one
Funda DP,Fundova P,Hansen AK,Buschard K
45-0081 was used in Flow cytometry/Cell sorting to investigate whether intranasal (i.n.) administration of gliadin or gluten may arrest the diabetogenic process, showing that i.n. administration of gliadin prevents type 1 diabetes in NOD mice.
Tue Jan 13 00:00:00 EST 2015
Isoniazid induces apoptosis of activated CD4+ T cells: implications for post-therapy tuberculosis reactivation and reinfection.
The Journal of biological chemistry
Tousif S,Singh DK,Ahmad S,Moodley P,Bhattacharyya M,Van Kaer L,Das G
45-0081 was used in Flow cytometry/Cell sorting to show that Isoniazid treatment of Mycobacterium tuberculosis treatment is associated with immune impairment.
Fri Oct 31 00:00:00 EDT 2014
Autoimmunity-associated LYP-W620 does not impair thymic negative selection of autoreactive T cells.
PloS one
Wu DJ,Zhou W,Enouz S,Orrú V,Stanford SM,Maine CJ,Rapini N,Sawatzke K,Engel I,Fiorillo E,Sherman LA,Kronenberg M,Zehn D,Peterson E,Bottini N
45-0081 was used in Flow cytometry/Cell sorting to investigate the mechanism of action of the R620W variant in autoimmunity.
Wed Dec 03 00:00:00 EST 2014
Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells.
Nature immunology
Pierson W,Cauwe B,Policheni A,Schlenner SM,Franckaert D,Berges J,Humblet-Baron S,Schönefeldt S,Herold MJ,Hildeman D,Strasser A,Bouillet P,Lu LF,Matthys P,Freitas AA,Luther RJ,Weaver CT,Dooley J,Gray DH,Liston A
45-0081 was used in Flow cytometry/Cell sorting to study the regulation of the Foxp3+ T cell pool by proliferation and apoptosis, and specifically the role of antiapoptoic Mcl-1 in T cell survival.
Sun Sep 01 00:00:00 EDT 2013
Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORγt and Ahr that leads to IL-17 production by activated B cells.
Nature immunology
Bermejo DA,Jackson SW,Gorosito-Serran M,Acosta-Rodriguez EV,Amezcua-Vesely MC,Sather BD,Singh AK,Khim S,Mucci J,Liggitt D,Campetella O,Oukka M,Gruppi A,Rawlings DJ
45-0081 was used in Flow cytometry/Cell sorting to study how the generation of IL-17 B cells may be a feature of innate immune responses required for pathogen control or IL-17-mediated autoimmunity.
Wed May 01 00:00:00 EDT 2013
Two-photon microscopy imaging of thy1GFP-M transgenic mice: a novel animal model to investigate brain dendritic cell subsets in vivo.
PloS one
Laperchia C,Allegra Mascaro AL,Sacconi L,Andrioli A,Mattè A,De Franceschi L,Grassi-Zucconi G,Bentivoglio M,Buffelli M,Pavone FS
45-0081 was used in Flow cytometry/Cell sorting to employ a transgenic mouse model to study professional antigen-presenting cells in the brain.
Mon Jul 29 00:00:00 EDT 2013
Murine cytomegalovirus immediate-early 1 gene expression correlates with increased GVHD after allogeneic hematopoietic cell transplantation in recipients reactivating from latent infection.
PloS one
Palaniyandi S,Radhakrishnan SV,Karlsson FJ,Stokes KY,Kittan N,Huber E,Hildebrandt GC
45-0081 was used in Flow cytometry/Cell sorting to assess the role of murine cytomegalovirus reactivation on graft-versus-host disease development.
Tue Oct 22 00:00:00 EDT 2013
IFNγ induces monopoiesis and inhibits neutrophil development during inflammation.
Blood
de Bruin AM,Libregts SF,Valkhof M,Boon L,Touw IP,Nolte MA
45-0081 was used in Flow cytometry/Cell sorting to demonstrate that the pro-inflammatory cytokine IFNγ is involved in orchestrating inflammation-induced myelopoiesis.
Thu Feb 09 00:00:00 EST 2012
Targeting of the non-mutated tumor antigen HER2/neu to mature dendritic cells induces an integrated immune response that protects against breast cancer in mice.
Breast cancer research : BCR
Wang B,Zaidi N,He LZ,Zhang L,Kuroiwa JM,Keler T,Steinman RM
45-0081 was used in Flow cytometry/Cell sorting to demonstrate how the immunisation of mice with HER2 vaccine confers high levels of T- and B-cell immunity, providing long-term survival benefit.
Wed Mar 07 00:00:00 EST 2012
Characterization of CD8+ T cell function and immunodominance generated with an H2O2-inactivated whole-virus vaccine.
Journal of virology
Walker JM,Raué HP,Slifka MK
45-0081 was used in Flow cytometry/Cell sorting to investigate the specific immune cell response to H(2)O(2)-LCMV vaccination.
Sat Dec 01 00:00:00 EST 2012
TLR9 and MyD88 are crucial for the development of protective immunity to malaria.
Journal of immunology (Baltimore, Md. : 1950)
Gowda NM,Wu X,Gowda DC
45-0081 was used in Flow cytometry/Cell sorting to investigate TLR9 and MyD88 regulation of pro/anti-inflammatory cytokines in mice infected with Plasmodium yoelii.
Tue May 15 00:00:00 EDT 2012
Small intestinal intraepithelial lymphocytes expressing CD8 and T cell receptor γδ are involved in bacterial clearance during Salmonella enterica serovar Typhimurium infection.
Infection and immunity
Li Z,Zhang C,Zhou Z,Zhang J,Zhang J,Tian Z
45-0081 was used in Flow cytometry/Cell sorting to investigate the role of intestinal intraepithelial lymphocytes in responding to oral infection, showing that they express CD8 and T cell receptor γδ for bacterial clearance.
Wed Feb 01 00:00:00 EST 2012
Role of gamma-delta T cells in host response against Staphylococcus aureus-induced pneumonia.
BMC immunology
Cheng P,Liu T,Zhou WY,Zhuang Y,Peng LS,Zhang JY,Yin ZN,Mao XH,Guo G,Shi Y,Zou QM
45-0081 was used in Flow cytometry/Cell sorting to examine the kinetics of the γδ T cell response in the lungs of mice infected with S. aureus.
Mon Jul 09 00:00:00 EDT 2012
RelA and RelB transcription factors in distinct thymocyte populations control lymphotoxin-dependent interleukin-17 production in γδ T cells.
Immunity
Powolny-Budnicka I,Riemann M,Tänzer S,Schmid RM,Hehlgans T,Weih F
45-0081 was used in Flow cytometry/Cell sorting to investigate the contribution of NF-κB to IL-17 production by T cells, showing that RelA and RelB in distinct thymocyte populations control lymphotoxin-dependent IL-17 production.
Fri Mar 25 00:00:00 EDT 2011
A critical role for SOCS3 in innate resistance to Toxoplasma gondii.
Cell host & microbe
Whitmarsh RJ,Gray CM,Gregg B,Christian DA,May MJ,Murray PJ,Hunter CA
45-0081 was used in Flow cytometry/Cell sorting to study the role of SOCS3 in suppressing IL-6 signalling during immune responses to T. gondii infection.
Thu Sep 15 00:00:00 EDT 2011
The transcriptional regulators Id2 and Id3 control the formation of distinct memory CD8+ T cell subsets.
Nature immunology
Yang CY,Best JA,Knell J,Yang E,Sheridan AD,Jesionek AK,Li HS,Rivera RR,Lind KC,D'Cruz LM,Watowich SS,Murre C,Goldrath AW
45-0081 was used in Flow cytometry/Cell sorting to elucidate the mechanisms of regulation of terminal differentiation of CD8(+) T cells.
Sun Nov 06 00:00:00 EDT 2011
Ly49D-mediated ITAM signaling in immature thymocytes impairs development by bypassing the pre-TCR checkpoint.
Journal of immunology (Baltimore, Md. : 1950)
Merck E,Lees RK,Voyle RB,Held W,MacDonald HR
45-0081 was used in Flow cytometry/Cell sorting to investigate the role of Ly49D-mediated ITAM signaling, showing that it impairs development by bypassing the pre-TCR checkpoint.
Fri Jul 01 00:00:00 EDT 2011
The magnitude of the T cell response to a clinically significant dose of influenza virus is regulated by TRAIL.
Journal of immunology (Baltimore, Md. : 1950)
Brincks EL,Gurung P,Langlois RA,Hemann EA,Legge KL,Griffith TS
45-0081 was used in Flow cytometry/Cell sorting to study how TRAIL affects the T cell response and ultimately influences the outcome of viral infection.
Tue Nov 01 00:00:00 EDT 2011
Topical imiquimod has therapeutic and immunomodulatory effects against intracranial tumors.
Journal of immunotherapy (Hagerstown, Md. : 1997)
Xiong Z,Ohlfest JR
45-0081 was used in Flow cytometry/Cell sorting to demonstrate that topical application of the TLR7 agonist imiquimod can enhance T-cell responses to intracranial tumors as a single agent in mice.
Fri Apr 01 00:00:00 EDT 2011
β-Actin specifically controls cell growth, migration, and the G-actin pool.
Molecular biology of the cell
Bunnell TM,Burbach BJ,Shimizu Y,Ervasti JM
45-0081 was used in Flow cytometry/Cell sorting to study the role of beta-actin in cell migration and gene expression.
Tue Nov 01 00:00:00 EDT 2011
Virulence of Toxoplasma gondii is associated with distinct dendritic cell responses and reduced numbers of activated CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950)
Tait ED,Jordan KA,Dupont CD,Harris TH,Gregg B,Wilson EH,Pepper M,Dzierszinski F,Roos DS,Hunter CA
45-0081 was used in Flow cytometry/Cell sorting to show the dendritic cell response to T.gondii alters levels of CD8+ T cells which ultimately determine the outcome of infection.
Sun Aug 01 00:00:00 EDT 2010
Naringenin: a potential immunomodulator for inhibiting lung fibrosis and metastasis.
Cancer research
Du G,Jin L,Han X,Song Z,Zhang H,Liang W
45-0081 was used in Flow cytometry/Cell sorting to determine whether mouse models of idiopathic pulmonary fibrosis have high incidence of lung cancer, showing that Naringenin could treat lung fibrosis and metastasis.
Wed Apr 01 00:00:00 EDT 2009
The human cancer antigen mesothelin is more efficiently presented to the mouse immune system when targeted to the DEC-205/CD205 receptor on dendritic cells.
Annals of the New York Academy of Sciences
Wang B,Kuroiwa JM,He LZ,Charalambous A,Keler T,Steinman RM
45-0081 was used in Flow cytometry/Cell sorting to show that targeting of mesothelin to DEC-205 improves the induction of CD4(+) and CD8(+) T-cell immunity accompanied by an antibody response.
Tue Sep 01 00:00:00 EDT 2009
Multiplexed labeling of samples with cell tracking dyes facilitates rapid and accurate internally controlled calcium flux measurement by flow cytometry.
Journal of immunological methods
Fu G,Gascoigne NR
45-0081 was used in Flow cytometry/Cell sorting to present an improved method to measure calcium flux that allows different lymphocyte populations to be tested in the same sample.
Sat Oct 31 00:00:00 EDT 2009
Suppression of alkali burn-induced corneal neovascularization by dendritic cell vaccination targeting VEGF receptor 2.
Investigative ophthalmology & visual science
Mochimaru H,Usui T,Yaguchi T,Nagahama Y,Hasegawa G,Usui Y,Shimmura S,Tsubota K,Amano S,Kawakami Y,Ishida S
Thu May 01 00:00:00 EDT 2008
Combined anti-CD40 conditioning and well-timed immunization prolongs CD8+ T cell accumulation and control of established brain tumors.
Journal of immunotherapy (Hagerstown, Md. : 1997)
Ryan CM,Staveley-O'Carroll K,Schell TD
45-0081 was used in Flow cytometry/Cell sorting to investigate the augmentation of CD8+ T-cell-mediated adoptive immunotherapy by targeting a weakly immunogenic epitope.
Mon Jul 13 00:00:00 EDT 2009
Myocardial infarct-sparing effect of adenosine A2A receptor activation is due to its action on CD4+ T lymphocytes.
Circulation
Yang Z,Day YJ,Toufektsian MC,Xu Y,Ramos SI,Marshall MA,French BA,Linden J
Tue Nov 07 00:00:00 EST 2006
