Profiling the HLA-II Immunopeptidome of SARS-CoV-2 Spike Glycoprotein Using Mass Spectrometry

In this webinar, learn how mass spectrometry has been used to identify more than 500 unique sequences from SARS-CoV-2 spike glycoprotein extracellular domain in a complex with human leukocyte antigen class II molecules on antigen presenting cells from a panel of healthy donors. This work by researchers at Eli Lilly and Co. represents the most precise and comprehensive HLA-II immunopeptidomic investigation with SARS-CoV-2 spike glycoprotein and allows for detailed analysis of features, which may aid crucial vaccine development.

Key Learning Objectives:

• How to use mass spectrometry-based approaches to examine immune response in viral infections
• Considerations for successful immunopeptidomics work
• Application of chosen approach in developing novel subunit or nucleic acid-based vaccines

Who Should Watch:

• Biopharmaceutical and vaccine scientists with an interest in exploration by mass spectrometry
• People interested in learning about the role of mass spectrometry in vaccine development

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