Liquid Biopsy
With its high precision and sensitivity, digital PCR is ideally suited for research applications such as liquid biopsy applications and rare mutation detection.
This education center is a centralized location for the presentation of educational resources across a wide array of digital PCR application areas. Select an application below to view a collection of learning resources on that subject, including articles, application notes, videos, and webinars.
Applications of Digital PCR articles
Vector Copy Number and Viral Titer Measurement for Cell and Gene Therapy Development
Digital PCR is a powerful and accurate method for vector copy number analysis and viral titer quantification in cell and gene therapy research applications.
Residual DNA and Mycoplasma Detection for Cell and Gene Therapy Development
Digital PCR offers a precise and accurate way to provide absolute quantification of residual DNA and mycoplasma detection.
Copy Number Variation
The advent of digital PCR now enables high-resolution determination of copy number variation through the accurate detection and quantification of low percent copy number differences.
Next-Generation Sequencing Library Quantification
The use of digital PCR as a quantification tool for NGS libraries before sequencing helps optimize sequencing run performance, data generation, and data quality.
Environmental Pathogen Quantification
With digital PCR it is possible to measure environmental pathogen concentration more accurately and precisely in what would be an otherwise highly inhibited sample.
Mastering dMIQE Guidelines for the Publication of dPCR Data
See specific recommendations from the Minimum Information for Publication of Quantitative Digital PCR (dMIQE) guidelines that can help support high-quality digital PCR (dPCR) experiments.
Digital PCR blog posts
What is digital PCR?
Digital PCR is a specialized approach to nucleic acid detection and quantification that estimates absolute numbers of molecules through statistical methods.
Streamline biologics development with qPCR and dPCR
Digital PCR and real-time PCR (qPCR) are core technologies for delivering high-quality results throughout biologics development and biomanufacturing.
Digital PCR for gene and cell therapy research
Digital PCR helps improve sensitivity and efficiency in viral vector production workflows.
Precision cancer monitoring with digital PCR
Digital PCR is emerging as an ideal technology for situations, such as cancer research, in which the need for high precision or a low abundance of the genetic target makes conventional qPCR challenging.
Studying spinal muscular atrophy with digital PCR
Digital PCR has been used to study genes involved in spinal muscular atrophy (SMA). A multiplex (dPCR) protocol has been developed that could make future research easier.
Using NGS and digital PCR together for improved liquid biopsies
Next-generation sequencing and digital PCR are two methods used to analyze circulating tumor DNA (ctDNA).