The Molecular Probes Handbook, 11th Edition Download

Thank you for your interest in The Molecular Probes® Handbook—A Guide to Fluorescent Probes and Labeling Technologies. Originally published by Dr. Richard Haugland of Molecular Probes, Inc., this publication served as both a product catalog and a comprehensive guide to using a diverse array of fluorescent products.

Here we have archived the most recent edition (11th Edition, printed in 2010) for easy access for our customers. The downloadable chapters linked below include chemical structures and properties of over 3000 products, cited applications as well as potential applications for product use.

You can access the online chapters using the left navigation or use the Related products links at the bottom of the page to access our most current product offerings.

Chapter Title
Introduction to Fluorescence Fundamentals (930 KB)
Part I—Choosing a Fluorescent Label: Their Properties and Labeling Chemistries
Chapter 1—Fluorophores and Their Amine-Reactive Derivatives (7.2 MB)
Chapter 2—Thiol-Reactive Probes (2.5 MB)
Chapter 3—Click Chemistry and Other Functional Group Modifications (1.8 MB)
Chapter 4—Biotin and Hapten Derivatives (1.4 MB)
Chapter 5—Crosslinking and Photoactivatable Reagents (1.6 MB)
Part II—Detecting Biomolecules: Signal Amplification and Secondary Detection
Chapter 6—Ultrasensitive Detection Technology (2.6 MB)
Chapter 7—Antibodies, Avidins and Lectins (2.7 MB)
Part III—Decoding Cell Components: Nucleic Acid and Protein Analysis
Chapter 8—Nucleic Acid Detection and Analysis (3.5 MB)
Chapter 9—Protein Detection and Analysis (2.4 MB)
Chapter 10—Enzyme Substrates and Assays (5.4 MB)
Part IV—Probing Cell Structure: From Organelles and Membranes to Whole Cells
Chapter 11—Probes for Cytoskeletal Proteins (1.5 MB)
Chapter 12—Probes for Organelles (3.4 MB)
Chapter 13—Probes for Lipids and Membranes (3.9 MB)
Chapter 14—Fluorescent Tracers of Cell Morphology and Fluid Flow (4.3 MB)
Chapter 15—Assays for Cell Viability, Proliferation and Function (6.5 MB)
Chapter 16—Probes for Endocytosis, Receptors and Ion Channels (3.2 MB)
Chapter 17—Probes for Signal Transduction (2.4 MB)
Chapter 18—Probes for Reactive Oxygen Species, Including Nitric Oxide (2.3 MB)
Chapter 19—Indicators for Ca2⁺, Mg2⁺, Zn2⁺ and Other Metal Ions (6.1 MB)
Chapter 20—pH Indicators (2.1 MB)
Chapter 21—Indicators for Na⁺, K⁺, Cl^– and Miscellaneous Ions (2.6 MB)
Chapter 22—Probes for Membrane Potential (1.6 MB)
Part VI—Integrating Technology and Instrumentation
Chapter 23—Antifades and Other Tools for Fluorescence Applications (1.7 MB)

The Molecular Probes Handbook, 11th Edition Downloads

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