Gibco

Mouse M-CSF, Animal-Free Recombinant Protein, PeproTech®

Product Details

AF-315-02-10UG

Applications

Tested Dilution

Publications

Functional Assay (Functional)

Assay-dependent

In vitro Assay (IV)

View 73 publications 73 publications

Miscellaneous PubMed (Misc)

View 3 publications 3 publications

Product Specifications

Species

Mouse

Published species

Mouse, Rat

Expression System

E. coli

Amino acid sequence

MKEVSEHCSH MIGNGHLKVL QQLIDSQMET SCQIAFEFVD QEQLDDPVCY LKKAFFLVQD IIDETMRFKD NTPNANATER LQELSNNLNS CFTKDYEEQN KACVRTFHET PLQLLEKIKN FFNETKNLLE KDWNIFTKNC NNSFAKCSSR DVVTKP

Molecular weight

36.4 kDa

Class

Recombinant

Type

Protein

Purity

≥ 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<0.1 EU/µg

Activity

Determined by its ability to stimulate the proliferation of murine M-NFS-60 cells. The expected ED50 is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 10^6 units/mg.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

Recombinant Murine M-CSF is a 36.4 kDa homodimeric protein consisting of two 156 amino acid polypeptide subunits.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

M-CSF (Macrophage colony-stimulating factor, CSF-1) is a survival factor essential for the proliferation and development of monocytes, macrophages, and osteoclast progenitor cells. M-CSF also induces VEGF (vascular endothelial growth factor) secretion by macrophages, thereby mediating mobilization of endothelial progenitor cells and neovascularization. M-CSF is present as several bioactive isoforms that differ in potency and stability. The full-length protein is synthesized as a membrane-spanning protein that can be expressed on the cell surface or further cleaved and modified in the secretory vesicle. Further, M-CSF is a disulfide-bonded homodimer which is processed into one of two isoforms, a glycoprotein or a proteoglycan that has been modified by the addition of chondroitin sulfate to each subunit. Binding of M-CSF to its receptor, c-Fms (CSF-1R or CD115) induces dimerization of the receptor followed by internalization and degradation of the complex. Functionally, M-CSF is known to stimulate differentiation of hematopoietic stem cells to monocyte-macrophage cell populations in culture. M-CSF acts through the CSF receptor 1. Although human M-CSF shows activity on mouse cells, mouse CSF shows no activity on human cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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Immunology

Ding L,Liang Y,Wang Y,Tong Z,Liu W,Tan S,Zhang J,Wang Y,Wu Z,Liang X,Ma C,Gao L

AF-315-02 was used in In vitro experiments to reveal that maintainence of adipose tissue homeostasis occurs via Tim-4 by regulating macrophage polarization via NF-κB pathway.

Sun Jan 01 00:00:00 EST 2023

Caspase-8 auto-cleavage regulates programmed cell death and collaborates with RIPK3/MLKL to prevent lymphopenia.

Cell death and differentiation

Li X,Li F,Zhang X,Zhang H,Zhao Q,Li M,Wu X,Wang L,Liu J,Wu X,Ou Y,Xing M,Zhang Y,Deng J,Wang X,Luo Y,Li J,Zhao Y,Zhang H

AF-315-02 was used in Cell Culture to demonstrate previously unappreciated roles for caspase-8 auto-cleavage in regulating necroptosis and maintaining lymphocytes homeostasis.

Mon Aug 01 00:00:00 EDT 2022

Sonic Hedgehog acts as a macrophage chemoattractant during regeneration of the gastric epithelium.

NPJ Regenerative medicine

Chakrabarti J,Dua-Awereh M,Schumacher M,Engevik A,Hawkins J,Helmrath MA,Zavros Y

AF-315-02 was used in In vitro experiments to investigate the extent of morphogenic sonic hedgehog in gastric epithelium regeneration.

Wed Jan 12 00:00:00 EST 2022

Diabetes fuels periodontal lesions via GLUT1-driven macrophage inflammaging.

International journal of oral science

Wang Q,Nie L,Zhao P,Zhou X,Ding Y,Chen Q,Wang Q

Wed Mar 24 00:00:00 EDT 2021

Priming of NLRP3 inflammasome activation by Msn kinase MINK1 in macrophages.

Cellular & molecular immunology

Zhu K,Jin X,Chi Z,Chen S,Wu S,Sloan RD,Lin X,Neculai D,Wang D,Hu H,Lu L

Fri Oct 01 00:00:00 EDT 2021

Disulfiram-loaded lactoferrin nanoparticles for treating inflammatory diseases.

Acta pharmacologica Sinica

Ou AT,Zhang JX,Fang YF,Wang R,Tang XP,Zhao PF,Zhao YG,Zhang M,Huang YZ

Mon Nov 01 00:00:00 EDT 2021

Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus.

Nature communications

Doni A,Parente R,Laface I,Magrini E,Cunha C,Colombo FS,Lacerda JF,Campos A,Mapelli SN,Petroni F,Porte R,Schorn T,Inforzato A,Mercier T,Lagrou K,Maertens J,Lambris JD,Bottazzi B,Garlanda C,Botto M,Carvalho A,Mantovani A

Fri Jun 18 00:00:00 EDT 2021

Auranofin prevents liver fibrosis by system Xc-mediated inhibition of NLRP3 inflammasome.

Communications biology

Kim HY,Choi YJ,Kim SK,Kim H,Jun DW,Yoon K,Kim N,Hwang J,Kim YM,Lim SC,Kang KW

Wed Jun 30 00:00:00 EDT 2021

Leishmania donovani infection suppresses Allograft Inflammatory Factor-1 in monocytes and macrophages to inhibit inflammatory responses.

Scientific reports

da Silva RL,Elizondo DM,Brandy NZD,Haddock NL,Boddie TA,de Oliveira LL,de Jesus AR,de Almeida RP,de Moura TR,Lipscomb MW

Wed Jan 13 00:00:00 EST 2021

Single-cell secretion analysis reveals a dual role for IL-10 in restraining and resolving the TLR4-induced inflammatory response.

Cell reports

Alexander AF,Kelsey I,Forbes H,Miller-Jensen K

Tue Sep 21 00:00:00 EDT 2021

TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation.

Nature communications

Iizasa E,Chuma Y,Uematsu T,Kubota M,Kawaguchi H,Umemura M,Toyonaga K,Kiyohara H,Yano I,Colonna M,Sugita M,Matsuzaki G,Yamasaki S,Yoshida H,Hara H

Fri Apr 16 00:00:00 EDT 2021

CALML6 Controls TAK1 Ubiquitination and Confers Protection against Acute Inflammation.

Journal of immunology (Baltimore, Md. : 1950)

Sheng C,Wang Z,Yao C,Chen HM,Kan G,Wang D,Chen H,Chen S

Mon Jun 01 00:00:00 EDT 2020

PERK controls bone homeostasis through the regulation of osteoclast differentiation and function.

Cell death & disease

Guo J,Ren R,Sun K,Yao X,Lin J,Wang G,Guo Z,Xu T,Guo F

Tue Oct 13 00:00:00 EDT 2020

Intervention of oncostatin M-driven mucosal inflammation by berberine exerts therapeutic property in chronic ulcerative colitis.

Cell death & disease

Li H,Feng C,Fan C,Yang Y,Yang X,Lu H,Lu Q,Zhu F,Xiang C,Zhang Z,He P,Zuo J,Tang W

Fri Apr 24 00:00:00 EDT 2020

Silencing lncRNA Lfar1 alleviates the classical activation and pyoptosis of macrophage in hepatic fibrosis.

Cell death & disease

Zhang K,Shi Z,Zhang M,Dong X,Zheng L,Li G,Han X,Yao Z,Han T,Hong W

Tue Feb 18 00:00:00 EST 2020

Genetically modified macrophages accomplish targeted gene delivery to the inflamed brain in transgenic Parkin Q311X(A) mice: importance of administration routes.

Scientific reports

Haney MJ,Zhao Y,Fay J,Duhyeong H,Wang M,Wang H,Li Z,Lee YZ,Karuppan MK,El-Hage N,Kabanov AV,Batrakova EV

Thu Jul 16 00:00:00 EDT 2020

TAGAP instructs Th17 differentiation by bridging Dectin activation to EPHB2 signaling in innate antifungal response.

Nature communications

Chen J,He R,Sun W,Gao R,Peng Q,Zhu L,Du Y,Ma X,Guo X,Zhang H,Tan C,Wang J,Zhang W,Weng X,Man J,Bauer H,Wang QK,Martin BN,Zhang CJ,Li X,Wang C

Mon Apr 20 00:00:00 EDT 2020

Bacterial and Fungal Toll-Like Receptor Activation Elicits Type I IFN Responses in Mast Cells.

Frontiers in immunology

Kornstädt L,Pierre S,Weigert A,Ebersberger S,Schäufele TJ,Kolbinger A,Schmid T,Cohnen J,Thomas D,Ferreirós N,Brüne B,Ebersberger I,Scholich K

AF-315-02 was used in Cell Culture to better understand the role of mast cells during the resolution phase of a local inflammation induced with the Toll-like receptor (TLR)-2 agonist zymosan.

Mon Jun 21 00:00:00 EDT 2021

Reactive oxygen species modulate macrophage immunosuppressive phenotype through the up-regulation of PD-L1.

Proceedings of the National Academy of Sciences of the United States of America

Roux C,Jafari SM,Shinde R,Duncan G,Cescon DW,Silvester J,Chu MF,Hodgson K,Berger T,Wakeham A,Palomero L,Garcia-Valero M,Pujana MA,Mak TW,McGaha TL,Cappello P,Gorrini C

Tue Mar 05 00:00:00 EST 2019

AhR controls redox homeostasis and shapes the tumor microenvironment in BRCA1-associated breast cancer.

Proceedings of the National Academy of Sciences of the United States of America

Kubli SP,Bassi C,Roux C,Wakeham A,Göbl C,Zhou W,Jafari SM,Snow B,Jones L,Palomero L,Thu KL,Cassetta L,Soong D,Berger T,Ramachandran P,Baniasadi SP,Duncan G,Lindzen M,Yarden Y,Herranz C,Lazaro C,Chu MF,Haight J,Tinto P,Silvester J,Cescon DW,Petit A,Pettersson S,Pollard JW,Mak TW,Pujana MA,Cappello P,Gorrini C

Tue Feb 26 00:00:00 EST 2019

An attenuated Zika virus NS4B protein mutant is a potent inducer of antiviral immune responses.

NPJ vaccines

Li G,Adam A,Luo H,Shan C,Cao Z,Fontes-Garfias CR,Sarathy VV,Teleki C,Winkelmann ER,Liang Y,Sun J,Bourne N,Barrett ADT,Shi PY,Wang T

Thu Oct 01 00:00:00 EDT 2020

The G2A Receptor Controls Polarization of Macrophage by Determining Their Localization Within the Inflamed Tissue.

Frontiers in immunology

Kern K,Schäfer SMG,Cohnen J,Pierre S,Osthues T,Tarighi N,Hohmann S,Ferreiros N,Brüne B,Weigert A,Geisslinger G,Sisignano M,Scholich K

AF-315-02 was used in In vitro experiments to study the role of the G-protein coupled receptor, G2A, in chemotactic migration and polarisation of macrophages, using the zymosan-model of acute inflammation.

Mon Oct 21 00:00:00 EDT 2019

Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis.

Immunity

Yona S,Kim KW,Wolf Y,Mildner A,Varol D,Breker M,Strauss-Ayali D,Viukov S,Guilliams M,Misharin A,Hume DA,Perlman H,Malissen B,Zelzer E,Jung S

Thu Jan 24 00:00:00 EST 2013

Genetic programs expressed in resting and IL-4 alternatively activated mouse and human macrophages: similarities and differences.

Blood

Martinez FO,Helming L,Milde R,Varin A,Melgert BN,Draijer C,Thomas B,Fabbri M,Crawshaw A,Ho LP,Ten Hacken NH,Cobos Jiménez V,Kootstra NA,Hamann J,Greaves DR,Locati M,Mantovani A,Gordon S

Thu Feb 28 00:00:00 EST 2013

Normal hematopoiesis and neurofibromin-deficient myeloproliferative disease require Erk.

The Journal of clinical investigation

Staser K,Park SJ,Rhodes SD,Zeng Y,He YZ,Shew MA,Gehlhausen JR,Cerabona D,Menon K,Chen S,Sun Z,Yuan J,Ingram DA,Nalepa G,Yang FC,Clapp DW

Tue Jan 01 00:00:00 EST 2013

Canonical Wnt signaling inhibits osteoclastogenesis independent of osteoprotegerin.

The Journal of cell biology

Albers J,Keller J,Baranowsky A,Beil FT,Catala-Lehnen P,Schulze J,Amling M,Schinke T

Mon Feb 18 00:00:00 EST 2013

An HLA-DRB1-coded signal transduction ligand facilitates inflammatory arthritis: a new mechanism of autoimmunity.

Journal of immunology (Baltimore, Md. : 1950)

Holoshitz J,Liu Y,Fu J,Joseph J,Ling S,Colletta A,Sharma P,Begun D,Goldstein S,Taichman R

Tue Jan 01 00:00:00 EST 2013

Interleukin-6/signal transducer and activator of transcription 3 (STAT3) pathway is essential for macrophage infiltration and myoblast proliferation during muscle regeneration.

The Journal of biological chemistry

Zhang C,Li Y,Wu Y,Wang L,Wang X,Du J

Fri Jan 18 00:00:00 EST 2013

Compensatory dendritic cell development mediated by BATF-IRF interactions.

Nature

Tussiwand R,Lee WL,Murphy TL,Mashayekhi M,KC W,Albring JC,Satpathy AT,Rotondo JA,Edelson BT,Kretzer NM,Wu X,Weiss LA,Glasmacher E,Li P,Liao W,Behnke M,Lam SS,Aurthur CT,Leonard WJ,Singh H,Stallings CL,Sibley LD,Schreiber RD,Murphy KM

Thu Oct 25 00:00:00 EDT 2012

The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.

Nature

Lee GS,Subramanian N,Kim AI,Aksentijevich I,Goldbach-Mansky R,Sacks DB,Germain RN,Kastner DL,Chae JJ

Thu Dec 06 00:00:00 EST 2012

TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes.

Cell

Wang X,Zhang X,Dong XP,Samie M,Li X,Cheng X,Goschka A,Shen D,Zhou Y,Harlow J,Zhu MX,Clapham DE,Ren D,Xu H

Fri Oct 12 00:00:00 EDT 2012

Signaling through cannabinoid receptor 2 suppresses murine dendritic cell migration by inhibiting matrix metalloproteinase 9 expression.

Blood

Adhikary S,Kocieda VP,Yen JH,Tuma RF,Ganea D

Thu Nov 01 00:00:00 EDT 2012

Induction of IL-4Rα-dependent microRNAs identifies PI3K/Akt signaling as essential for IL-4-driven murine macrophage proliferation in vivo.

Blood

Rückerl D,Jenkins SJ,Laqtom NN,Gallagher IJ,Sutherland TE,Duncan S,Buck AH,Allen JE

Thu Sep 13 00:00:00 EDT 2012

Kruppel-like factor 7 overexpression suppresses hematopoietic stem and progenitor cell function.

Blood

Schuettpelz LG,Gopalan PK,Giuste FO,Romine MP,van Os R,Link DC

Thu Oct 11 00:00:00 EDT 2012

C/EBPε mediates nicotinamide-enhanced clearance of Staphylococcus aureus in mice.

The Journal of clinical investigation

Kyme P,Thoennissen NH,Tseng CW,Thoennissen GB,Wolf AJ,Shimada K,Krug UO,Lee K,Müller-Tidow C,Berdel WE,Hardy WD,Gombart AF,Koeffler HP,Liu GY

Sat Sep 01 00:00:00 EDT 2012

Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages.

The Journal of experimental medicine

Satpathy AT,KC W,Albring JC,Edelson BT,Kretzer NM,Bhattacharya D,Murphy TL,Murphy KM

Mon Jun 04 00:00:00 EDT 2012

Identification of Axl as a downstream effector of TGF-β1 during Langerhans cell differentiation and epidermal homeostasis.

The Journal of experimental medicine

Bauer T,Zagórska A,Jurkin J,Yasmin N,Köffel R,Richter S,Gesslbauer B,Lemke G,Strobl H

Mon Oct 22 00:00:00 EDT 2012

TNF-induced osteoclastogenesis and inflammatory bone resorption are inhibited by transcription factor RBP-J.

The Journal of experimental medicine

Zhao B,Grimes SN,Li S,Hu X,Ivashkiv LB

Mon Feb 13 00:00:00 EST 2012

Plasma membrane calcium ATPase regulates bone mass by fine-tuning osteoclast differentiation and survival.

The Journal of cell biology

Kim HJ,Prasad V,Hyung SW,Lee ZH,Lee SW,Bhargava A,Pearce D,Lee Y,Kim HH

Mon Dec 24 00:00:00 EST 2012

Nasal Acai polysaccharides potentiate innate immunity to protect against pulmonary Francisella tularensis and Burkholderia pseudomallei Infections.

PLoS pathogens

Skyberg JA,Rollins MF,Holderness JS,Marlenee NL,Schepetkin IA,Goodyear A,Dow SW,Jutila MA,Pascual DW

Mon Jul 09 00:00:00 EDT 2012

Mechanisms of NK cell-macrophage Bacillus anthracis crosstalk: a balance between stimulation by spores and differential disruption by toxins.

PLoS pathogens

Klezovich-Bénard M,Corre JP,Jusforgues-Saklani H,Fiole D,Burjek N,Tournier JN,Goossens PL

Sun Jan 01 00:00:00 EST 2012

The pore-forming toxin β hemolysin/cytolysin triggers p38 MAPK-dependent IL-10 production in macrophages and inhibits innate immunity.

PLoS pathogens

Bebien M,Hensler ME,Davanture S,Hsu LC,Karin M,Park JM,Alexopoulou L,Liu GY,Nizet V,Lawrence T

Tue Jan 29 00:00:00 EST 2013

Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4.

Arthritis research & therapy

Sohn DH,Sokolove J,Sharpe O,Erhart JC,Chandra PE,Lahey LJ,Lindstrom TM,Hwang I,Boyer KA,Andriacchi TP,Robinson WH

Sun Jan 08 00:00:00 EST 2012

Autoreactive preplasma cells break tolerance in the absence of regulation by dendritic cells and macrophages.

Journal of immunology (Baltimore, Md. : 1950)

Gilbert MR,Wagner NJ,Jones SZ,Wisz AB,Roques JR,Krum KN,Lee SR,Nickeleit V,Hulbert C,Thomas JW,Gauld SB,Vilen BJ

Sun Jul 15 00:00:00 EDT 2012

5-Lipoxygenase mediates RANKL-induced osteoclast formation via the cysteinyl leukotriene receptor 1.

Journal of immunology (Baltimore, Md. : 1950)

Lee JM,Park H,Noh AL,Kang JH,Chen L,Zheng T,Lee J,Ji SY,Jang CY,Shin CS,Ha H,Lee ZH,Park HY,Lee DS,Yim M

Sat Dec 01 00:00:00 EST 2012

Regulation of B cell linker protein transcription by PU.1 and Spi-B in murine B cell acute lymphoblastic leukemia.

Journal of immunology (Baltimore, Md. : 1950)

Xu LS,Sokalski KM,Hotke K,Christie DA,Zarnett O,Piskorz J,Thillainadesan G,Torchia J,DeKoter RP

Mon Oct 01 00:00:00 EDT 2012

Activation of the NLRP3 inflammasome by group B streptococci.

Journal of immunology (Baltimore, Md. : 1950)

Costa A,Gupta R,Signorino G,Malara A,Cardile F,Biondo C,Midiri A,Galbo R,Trieu-Cuot P,Papasergi S,Teti G,Henneke P,Mancuso G,Golenbock DT,Beninati C

Wed Feb 15 00:00:00 EST 2012

Sialoadhesin promotes rapid proinflammatory and type I IFN responses to a sialylated pathogen, Campylobacter jejuni.

Journal of immunology (Baltimore, Md. : 1950)

Klaas M,Oetke C,Lewis LE,Erwig LP,Heikema AP,Easton A,Willison HJ,Crocker PR

Sat Sep 01 00:00:00 EDT 2012

Size-dependent attenuation of TLR9 signaling by gold nanoparticles in macrophages.

Journal of immunology (Baltimore, Md. : 1950)

Tsai CY,Lu SL,Hu CW,Yeh CS,Lee GB,Lei HY

Sun Jan 01 00:00:00 EST 2012

IL-10 regulates Il12b expression via histone deacetylation: implications for intestinal macrophage homeostasis.

Journal of immunology (Baltimore, Md. : 1950)

Kobayashi T,Matsuoka K,Sheikh SZ,Russo SM,Mishima Y,Collins C,deZoeten EF,Karp CL,Ting JP,Sartor RB,Plevy SE

Wed Aug 15 00:00:00 EDT 2012

Cutting edge: IL-10-mediated tristetraprolin induction is part of a feedback loop that controls macrophage STAT3 activation and cytokine production.

Journal of immunology (Baltimore, Md. : 1950)

Gaba A,Grivennikov SI,Do MV,Stumpo DJ,Blackshear PJ,Karin M

Sat Sep 01 00:00:00 EDT 2012

Retinoic acid attenuates rheumatoid inflammation in mice.

Journal of immunology (Baltimore, Md. : 1950)

Kwok SK,Park MK,Cho ML,Oh HJ,Park EM,Lee DG,Lee J,Kim HY,Park SH

Sun Jul 15 00:00:00 EDT 2012

Lyn but not Fyn kinase controls IgG-mediated systemic anaphylaxis.

Journal of immunology (Baltimore, Md. : 1950)

Falanga YT,Chaimowitz NS,Charles N,Finkelman FD,Pullen NA,Barbour S,Dholaria K,Faber T,Kolawole M,Huang B,Odom S,Rivera J,Carlyon J,Conrad DH,Spiegel S,Oskeritzian CA,Ryan JJ

Tue May 01 00:00:00 EDT 2012

CD137 ligand activated microglia induces oligodendrocyte apoptosis via reactive oxygen species.

Journal of neuroinflammation

Yeo YA,Martínez Gómez JM,Croxford JL,Gasser S,Ling EA,Schwarz H

Mon Jul 16 00:00:00 EDT 2012

Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells.

Molecular therapy. Nucleic acids

Novobrantseva TI,Borodovsky A,Wong J,Klebanov B,Zafari M,Yucius K,Querbes W,Ge P,Ruda VM,Milstein S,Speciner L,Duncan R,Barros S,Basha G,Cullis P,Akinc A,Donahoe JS,Narayanannair Jayaprakash K,Jayaraman M,Bogorad RL,Love K,Whitehead K,Levins C,Manoharan M,Swirski FK,Weissleder R,Langer R,Anderson DG,de Fougerolles A,Nahrendorf M,Koteliansky V

Tue Jan 24 00:00:00 EST 2012

A cell permeable peptide inhibitor of NFAT inhibits macrophage cytokine expression and ameliorates experimental colitis.

PloS one

Elloumi HZ,Maharshak N,Rao KN,Kobayashi T,Ryu HS,Mühlbauer M,Li F,Jobin C,Plevy SE

Mon Nov 05 00:00:00 EST 2012

Inhibition of osteoclastogenesis by RNA interference targeting RANK.

BMC musculoskeletal disorders

Ma R,Xu J,Dong B,Kauther MD,Jäger M,Wedemeyer C

Wed Aug 22 00:00:00 EDT 2012

Enoxacin directly inhibits osteoclastogenesis without inducing apoptosis.

The Journal of biological chemistry

Toro EJ,Zuo J,Ostrov DA,Catalfamo D,Bradaschia-Correa V,Arana-Chavez V,Caridad AR,Neubert JK,Wronski TJ,Wallet SM,Holliday LS

Fri May 18 00:00:00 EDT 2012

TRAF family member-associated NF-κB activator (TANK) is a negative regulator of osteoclastogenesis and bone formation.

The Journal of biological chemistry

Maruyama K,Kawagoe T,Kondo T,Akira S,Takeuchi O

Fri Aug 17 00:00:00 EDT 2012

Phospholipase Cγ-2 and intracellular calcium are required for lipopolysaccharide-induced Toll-like receptor 4 (TLR4) endocytosis and interferon regulatory factor 3 (IRF3) activation.

The Journal of biological chemistry

Chiang CY,Veckman V,Limmer K,David M

Fri Feb 03 00:00:00 EST 2012

Myeloid TAKI [corrected] acts as a negative regulator of the LPS response and mediates resistance to endotoxemia.

PloS one

Eftychi C,Karagianni N,Alexiou M,Apostolaki M,Kollias G

Tue Jul 31 00:00:00 EDT 2012

25(OH)D(3) affects the maturation and function of mouse bone marrow-derived dendritic cells stimulated by Mycobacterium bovis BCG.

PloS one

Yang HF,Zhang ZH,Xiang LB,Tang KL,Luo F,Liu CY,Zhou JB,Li JQ,Xu JZ

Thu Apr 25 00:00:00 EDT 2013

c-Fms signaling mediates neurofibromatosis Type-1 osteoclast gain-in-functions.

PloS one

He Y,Rhodes SD,Chen S,Wu X,Yuan J,Yang X,Jiang L,Li X,Takahashi N,Xu M,Mohammad KS,Guise TA,Yang FC

Mon Apr 22 00:00:00 EDT 2013

Transgenic mice for a tamoxifen-induced, conditional expression of the Cre recombinase in osteoclasts.

PloS one

Sanchez-Fernandez MA,Sbacchi S,Correa-Tapia M,Naumann R,Klemm J,Chambon P,Al-Robaiy S,Blessing M,Hoflack B

Wed Sep 19 00:00:00 EDT 2012

Transcriptomic signature of Leishmania infected mice macrophages: a metabolic point of view.

PLoS neglected tropical diseases

Rabhi I,Rabhi S,Ben-Othman R,Rasche A,Daskalaki A,Trentin B,Piquemal D,Regnault B,Descoteaux A,Guizani-Tabbane L

Thu Jan 03 00:00:00 EST 2013

Osteoclasts in multiple myeloma are derived from Gr-1+CD11b+myeloid-derived suppressor cells.

PloS one

Zhuang J,Zhang J,Lwin ST,Edwards JR,Edwards CM,Mundy GR,Yang X

Thu Mar 14 00:00:00 EDT 2013

Decreased autocrine EGFR signaling in metastatic breast cancer cells inhibits tumor growth in bone and mammary fat pad.

PloS one

Nickerson NK,Mohammad KS,Gilmore JL,Crismore E,Bruzzaniti A,Guise TA,Foley J

Mon Jun 04 00:00:00 EDT 2012

Reciprocal interaction between macrophages and T cells stimulates IFN-γ and MCP-1 production in Ang II-induced cardiac inflammation and fibrosis.

PloS one

Han YL,Li YL,Jia LX,Cheng JZ,Qi YF,Zhang HJ,Du J

Mon Sep 17 00:00:00 EDT 2012

Development of an all-in-one inducible lentiviral vector for gene specific analysis of reprogramming.

PloS one

Yamaguchi T,Hamanaka S,Kamiya A,Okabe M,Kawarai M,Wakiyama Y,Umino A,Hayama T,Sato H,Lee YS,Kato-Itoh M,Masaki H,Kobayashi T,Yamazaki S,Nakauchi H

Wed Jan 16 00:00:00 EST 2013

Development of an all-in-one inducible lentiviral vector for gene specific analysis of reprogramming.

PloS one

Yamaguchi T,Hamanaka S,Kamiya A,Okabe M,Kawarai M,Wakiyama Y,Umino A,Hayama T,Sato H,Lee YS,Kato-Itoh M,Masaki H,Kobayashi T,Yamazaki S,Nakauchi H

Wed Jan 16 00:00:00 EST 2013

Unc93B1 restricts systemic lethal inflammation by orchestrating Toll-like receptor 7 and 9 trafficking.

Immunity

Fukui R,Saitoh S,Kanno A,Onji M,Shibata T,Ito A,Onji M,Matsumoto M,Akira S,Yoshida N,Miyake K

Fri Jul 22 00:00:00 EDT 2011

CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses in mice.

The Journal of clinical investigation

Medina-Contreras O,Geem D,Laur O,Williams IR,Lira SA,Nusrat A,Parkos CA,Denning TL

Thu Dec 01 00:00:00 EST 2011

Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells.

Proceedings of the National Academy of Sciences of the United States of America

Martinez J,Almendinger J,Oberst A,Ness R,Dillon CP,Fitzgerald P,Hengartner MO,Green DR

Tue Oct 18 00:00:00 EDT 2011

Erk1 positively regulates osteoclast differentiation and bone resorptive activity.

PloS one

He Y,Staser K,Rhodes SD,Liu Y,Wu X,Park SJ,Yuan J,Yang X,Li X,Jiang L,Chen S,Yang FC

Thu Mar 01 00:00:00 EST 2012

Profibrotic potential of prominin-1+ epithelial progenitor cells in pulmonary fibrosis.

Respiratory research

Blyszczuk P,Germano D,Stein S,Moch H,Matter CM,Beck-Schimmer B,Lüscher TF,Eriksson U,Kania G

Mon Sep 26 00:00:00 EDT 2011

Internal control genes for quantitative RT-PCR expression analysis in mouse osteoblasts, osteoclasts and macrophages.

BMC research notes

Stephens AS,Stephens SR,Morrison NA

Fri Oct 14 00:00:00 EDT 2011

Osteoblasts are a major source of inflammatory cytokines in the tumor microenvironment of bone metastatic breast cancer.

Journal of cellular biochemistry

Bussard KM,Venzon DJ,Mastro AM

Wed Dec 01 00:00:00 EST 2010

Bioinformatics

Protein Aliases: CSF-1; H-MCSF; M-MCSF; Macrophage colony-stimulating factor 1; MGC31930; osteopetrosis; PG-M-CSF; Proteoglycan macrophage colony-stimulating factor

Mouse M-CSF, Animal-Free Recombinant Protein, PeproTech®

Product Details

AF-315-02-10UG

Functional Assay (Functional)

In vitro Assay (IV)

Miscellaneous PubMed (Misc)

Species

Published species

Expression System

Amino acid sequence

Molecular weight

Class

Type

Purity

Endotoxin concentration

Activity

Conjugate

Form

Purification

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

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