Product References
Generation and characterization of NGLY1 patient-derived midbrain organoids.
Frontiers in cell and developmental biology
Abbott J,Tambe M,Pavlinov I,Farkhondeh A,Nguyen HN,Xu M,Pradhan M,York T,Might M,Baumgärtel K,Rodems S,Zheng W
100-25 was used in Cell Culture to provide a relevant NGLY1 disease model to investigate disease mechanisms and evaluate therapeutics for treatments of NGLY1 deficiency.
Tue Mar 07 00:00:00 EST 2023
DYT6 mutated THAP1 is a cell type dependent regulator of the SP1 family.
Brain : a journal of neurology
Cheng F,Zheng W,Barbuti PA,Bonsi P,Liu C,Casadei N,Ponterio G,Meringolo M,Admard J,Dording CM,Yu-Taeger L,Nguyen HP,Grundmann-Hauser K,Ott T,Houlden H,Pisani A,Krüger R,Riess O
100-25 was used in Cell Culture to characterize the function of THAP1 and contributes to the understanding of the pathogenesis of primary dystonia in humans and rats.
Mon Nov 21 00:00:00 EST 2022
Intronic enhancers of the human SNCA gene predominantly regulate its expression in brain in vivo.
Science advances
Cheng F,Zheng W,Liu C,Barbuti PA,Yu-Taeger L,Casadei N,Huebener-Schmid J,Admard J,Boldt K,Junger K,Ueffing M,Houlden H,Sharma M,Kruger R,Grundmann-Hauser K,Ott T,Riess O
100-25 was used in Cell Culture to identify that the DYT6 gene product THAP1 (THAP domain-containing apoptosis-associated protein 1) and its interaction partner CTCF (CCCTC-binding factor) act as transcription regulators of SNCA.
Fri Nov 25 00:00:00 EST 2022
Protocol for the generation and expansion of human iPS cell-derived ureteric bud organoids.
STAR protocols
Ryosaka M,Mae SI,Osafune K
100-25 was used in Cell Culture to describe a protocol for the generation of i(ureteric bud)UB organoids from human iPSCs and describe how to expand iUB-organoid-derived tip colonies and how to induce collecting duct (CD) progenitors from iUB organoids.
Fri Sep 16 00:00:00 EDT 2022
Spotting-based differentiation of functional dopaminergic progenitors from human pluripotent stem cells.
Nature protocols
Kim J,Jeon J,Song B,Lee N,Ko S,Cha Y,Leblanc P,Seo H,Kim KS
100-25 was used in Cell Culture to present a protocol detailing how to grow hPSCs such as human induced pluripotent and embryonic stem cells in a physically confined area ('spot') and efficiently differentiate them into a highly enriched population of healthy and functional midbrain dopamine progenitors (mDAPs) and midbrain dopamine neurons (mDANs).
Tue Mar 01 00:00:00 EST 2022
Human Stem Cell-Derived Neurons Repair Circuits and Restore Neural Function.
Cell stem cell
Xiong M,Tao Y,Gao Q,Feng B,Yan W,Zhou Y,Kotsonis TA,Yuan T,You Z,Wu Z,Xi J,Haberman A,Graham J,Block J,Zhou W,Chen Y,Zhang SC
Thu Jan 07 00:00:00 EST 2021
Targeted attenuation of elevated histone marks at SNCA alleviates α-synuclein in Parkinson's disease.
EMBO molecular medicine
Guhathakurta S,Kim J,Adams L,Basu S,Song MK,Adler E,Je G,Fiadeiro MB,Kim YS
Fri Feb 05 00:00:00 EST 2021
Alpha-synuclein dynamics in induced pluripotent stem cell-derived dopaminergic neurons from a Parkinson's disease patient (PARK4) with SNCA triplication.
FEBS open bio
Fukusumi H,Togo K,Sumida M,Nakamori M,Obika S,Baba K,Shofuda T,Ito D,Okano H,Mochizuki H,Kanemura Y
Mon Feb 01 00:00:00 EST 2021
16p11.2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networks and is rescued by RHOA inhibition in vitro.
Nature communications
Sundberg M,Pinson H,Smith RS,Winden KD,Venugopal P,Tai DJC,Gusella JF,Talkowski ME,Walsh CA,Tegmark M,Sahin M
Tue May 18 00:00:00 EDT 2021
Secreted retrovirus-like GAG-domain-containing protein PEG10 is regulated by UBE3A and is involved in Angelman syndrome pathophysiology.
Cell reports. Medicine
Pandya NJ,Wang C,Costa V,Lopatta P,Meier S,Zampeta FI,Punt AM,Mientjes E,Grossen P,Distler T,Tzouros M,Martí Y,Banfai B,Patsch C,Rasmussen S,Hoener M,Berrera M,Kremer T,Dunkley T,Ebeling M,Distel B,Elgersma Y,Jagasia R
Tue Aug 17 00:00:00 EDT 2021
α-Synuclein mutation impairs processing of endomembrane compartments and promotes exocytosis and seeding of α-synuclein pathology.
Cell reports
Stykel MG,Humphries KM,Kamski-Hennekam E,Buchner-Duby B,Porte-Trachsel N,Ryan T,Coackley CL,Bamm VV,Harauz G,Ryan SD
Tue May 11 00:00:00 EDT 2021
Direct conversion of human fibroblasts into dopaminergic neuron-like cells using small molecules and protein factors.
Military Medical Research
Qin H,Zhao AD,Sun ML,Ma K,Fu XB
100-25 was used in Sample Preparation to develope a chemical cocktail of small molecules and protein factors to convert human fibroblasts into DA neuron-like cells without passing through a neural progenitor/stem cell intermediate stage.
Sun Nov 01 00:00:00 EDT 2020
MiT/TFE factors control ER-phagy via transcriptional regulation of FAM134B.
The EMBO journal
Cinque L,De Leonibus C,Iavazzo M,Krahmer N,Intartaglia D,Salierno FG,De Cegli R,Di Malta C,Svelto M,Lanzara C,Maddaluno M,Wanderlingh LG,Huebner AK,Cesana M,Bonn F,Polishchuk E,Hübner CA,Conte I,Dikic I,Mann M,Ballabio A,Sacco F,Grumati P,Settembre C
Tue Sep 01 00:00:00 EDT 2020
Novel genetic features of human and mouse Purkinje cell differentiation defined by comparative transcriptomics.
Proceedings of the National Academy of Sciences of the United States of America
Buchholz DE,Carroll TS,Kocabas A,Zhu X,Behesti H,Faust PL,Stalbow L,Fang Y,Hatten ME
Tue Jun 30 00:00:00 EDT 2020
R-spondins are BMP receptor antagonists in Xenopus early embryonic development.
Nature communications
Lee H,Seidl C,Sun R,Glinka A,Niehrs C
Wed Nov 04 00:00:00 EST 2020
In Vitro CRISPR/Cas9-Directed Gene Editing to Model LRRK2 G2019S Parkinson's Disease in Common Marmosets.
Scientific reports
Vermilyea SC,Babinski A,Tran N,To S,Guthrie S,Kluss JH,Schmidt JK,Wiepz GJ,Meyer MG,Murphy ME,Cookson MR,Emborg ME,Golos TG
Wed Feb 26 00:00:00 EST 2020
BrainPhys neuronal medium optimized for imaging and optogenetics in vitro.
Nature communications
Zabolocki M,McCormack K,van den Hurk M,Milky B,Shoubridge AP,Adams R,Tran J,Mahadevan-Jansen A,Reineck P,Thomas J,Hutchinson MR,Mak CKH,Añonuevo A,Chew LH,Hirst AJ,Lee VM,Knock E,Bardy C
Tue Nov 03 00:00:00 EST 2020
Interferon-γ signaling synergizes with LRRK2 in neurons and microglia derived from human induced pluripotent stem cells.
Nature communications
Panagiotakopoulou V,Ivanyuk D,De Cicco S,Haq W,Arsić A,Yu C,Messelodi D,Oldrati M,Schöndorf DC,Perez MJ,Cassatella RP,Jakobi M,Schneiderhan-Marra N,Gasser T,Nikić-Spiegel I,Deleidi M
Wed Oct 14 00:00:00 EDT 2020
Endothelial, pericyte and tumor cell expression in glioblastoma identifies fibroblast activation protein (FAP) as an excellent target for immunotherapy.
Clinical & translational immunology
Ebert LM,Yu W,Gargett T,Toubia J,Kollis PM,Tea MN,Ebert BW,Bardy C,van den Hurk M,Bonder CS,Manavis J,Ensbey KS,Oksdath Mansilla M,Scheer KG,Perrin SL,Ormsby RJ,Poonnoose S,Koszyca B,Pitson SM,Day BW,Gomez GA,Brown MP
Sun Apr 17 00:00:00 EDT 2022
CRISPR/Cas9-mediated generation of a tyrosine hydroxylase reporter iPSC line for live imaging and isolation of dopaminergic neurons.
Scientific reports
Calatayud C,Carola G,Fernández-Carasa I,Valtorta M,Jiménez-Delgado S,Díaz M,Soriano-Fradera J,Cappelletti G,García-Sancho J,Raya Á,Consiglio A
100-25 was used in Cell Culture to investigate induced pluripotent stem cells use in Parkinson’s.
Thu May 02 00:00:00 EDT 2019
FGF family members differentially regulate maturation and proliferation of stem cell-derived astrocytes.
Scientific reports
Savchenko E,Teku GN,Boza-Serrano A,Russ K,Berns M,Deierborg T,Lamas NJ,Wichterle H,Rothstein J,Henderson CE,Vihinen M,Roybon L
Wed Jul 03 00:00:00 EDT 2019
FGF family members differentially regulate maturation and proliferation of stem cell-derived astrocytes.
Scientific reports
Savchenko E,Teku GN,Boza-Serrano A,Russ K,Berns M,Deierborg T,Lamas NJ,Wichterle H,Rothstein J,Henderson CE,Vihinen M,Roybon L
Wed Jul 03 00:00:00 EDT 2019
Generation and post-injury integration of human spinal cord neural stem cells.
Nature methods
Kumamaru H,Kadoya K,Adler AF,Takashima Y,Graham L,Coppola G,Tuszynski MH
Sat Sep 01 00:00:00 EDT 2018
Wnt signal activation induces midbrain specification through direct binding of the beta-catenin/TCF4 complex to the EN1 promoter in human pluripotent stem cells.
Experimental & molecular medicine
Kim JY,Lee JS,Hwang HS,Lee DR,Park CY,Jung SJ,You YR,Kim DS,Kim DW
Fri Apr 13 00:00:00 EDT 2018
Patch-Seq Protocol to Analyze the Electrophysiology, Morphology and Transcriptome of Whole Single Neurons Derived From Human Pluripotent Stem Cells.
Frontiers in molecular neuroscience
van den Hurk M,Erwin JA,Yeo GW,Gage FH,Bardy C
100-25 was used in Cell Culture to combine scRNA-seq with patch-clamping electrophysiological recording and morphological analysis of single human neurons in vitro which could be used on neurons in vitro to profile cell types and states in depth to unravel the human molecular basis of neuronal diversity and investigate the cellular mechanisms underlying brain disorders.
Wed Sep 30 00:00:00 EDT 2020
Human Clinical-Grade Parthenogenetic ESC-Derived Dopaminergic Neurons Recover Locomotive Defects of Nonhuman Primate Models of Parkinson's Disease.
Stem cell reports
Wang YK,Zhu WW,Wu MH,Wu YH,Liu ZX,Liang LM,Sheng C,Hao J,Wang L,Li W,Zhou Q,Hu BY
Tue Jul 10 00:00:00 EDT 2018
TNF inhibits catecholamine production from induced sympathetic neuron-like cells in rheumatoid arthritis and osteoarthritis in vitro.
Scientific reports
Herrmann M,Anders S,Straub RH,Jenei-Lanzl Z
Mon Jun 25 00:00:00 EDT 2018
A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation.
Nature communications
Sheng C,Jungverdorben J,Wiethoff H,Lin Q,Flitsch LJ,Eckert D,Hebisch M,Fischer J,Kesavan J,Weykopf B,Schneider L,Holtkamp D,Beck H,Till A,Wüllner U,Ziller MJ,Wagner W,Peitz M,Brüstle O
Tue Oct 02 00:00:00 EDT 2018
Transcriptional synergy as an emergent property defining cell subpopulation identity enables population shift.
Nature communications
Okawa S,Saltó C,Ravichandran S,Yang S,Toledo EM,Arenas E,Del Sol A
Tue Jul 03 00:00:00 EDT 2018
Development of Gonadotropin-Releasing Hormone-Secreting Neurons from Human Pluripotent Stem Cells.
Stem cell reports
Lund C,Pulli K,Yellapragada V,Giacobini P,Lundin K,Vuoristo S,Tuuri T,Noisa P,Raivio T
Tue Aug 09 00:00:00 EDT 2016
FolR1: a novel cell surface marker for isolating midbrain dopamine neural progenitors and nascent dopamine neurons.
Scientific reports
Gennet N,Tamburini C,Nan X,Li M
Thu Sep 01 00:00:00 EDT 2016
Multipotent caudal neural progenitors derived from human pluripotent stem cells that give rise to lineages of the central and peripheral nervous system.
Stem cells (Dayton, Ohio)
Denham M,Hasegawa K,Menheniott T,Rollo B,Zhang D,Hough S,Alshawaf A,Febbraro F,Ighaniyan S,Leung J,Elliott DA,Newgreen DF,Pera MF,Dottori M
Mon Jun 01 00:00:00 EDT 2015
A long pentraxin-3-derived pentapeptide for the therapy of FGF8b-driven steroid hormone-regulated cancers.
Oncotarget
Giacomini A,Matarazzo S,Pagano K,Ragona L,Rezzola S,Corsini M,Di Salle E,Presta M,Ronca R
Sat May 30 00:00:00 EDT 2015
A long pentraxin-3-derived pentapeptide for the therapy of FGF8b-driven steroid hormone-regulated cancers.
Oncotarget
Giacomini A,Matarazzo S,Pagano K,Ragona L,Rezzola S,Corsini M,Di Salle E,Presta M,Ronca R
Sat May 30 00:00:00 EDT 2015
A long pentraxin-3-derived pentapeptide for the therapy of FGF8b-driven steroid hormone-regulated cancers.
Oncotarget
Giacomini A,Matarazzo S,Pagano K,Ragona L,Rezzola S,Corsini M,Di Salle E,Presta M,Ronca R
Sat May 30 00:00:00 EDT 2015
A long pentraxin-3-derived pentapeptide for the therapy of FGF8b-driven steroid hormone-regulated cancers.
Oncotarget
Giacomini A,Matarazzo S,Pagano K,Ragona L,Rezzola S,Corsini M,Di Salle E,Presta M,Ronca R
Sat May 30 00:00:00 EDT 2015
Differentiation of human ESCs to retinal ganglion cells using a CRISPR engineered reporter cell line.
Scientific reports
Sluch VM,Davis CH,Ranganathan V,Kerr JM,Krick K,Martin R,Berlinicke CA,Marsh-Armstrong N,Diamond JS,Mao HQ,Zack DJ
Fri Nov 13 00:00:00 EST 2015
Selective Generation of Dopaminergic Precursors from Mouse Fibroblasts by Direct Lineage Conversion.
Scientific reports
Tian C,Li Y,Huang Y,Wang Y,Chen D,Liu J,Deng X,Sun L,Anderson K,Qi X,Li Y,Lee Mosley R,Chen X,Huang J,Zheng JC
Thu Jul 30 00:00:00 EDT 2015
Generation of Dopamine Neurons from Rodent Fibroblasts through the Expandable Neural Precursor Cell Stage.
The Journal of biological chemistry
Lim MS,Chang MY,Kim SM,Yi SH,Suh-Kim H,Jung SJ,Kim MJ,Kim JH,Lee YS,Lee SY,Kim DW,Lee SH,Park CH
Fri Jul 10 00:00:00 EDT 2015
Deterministic HOX patterning in human pluripotent stem cell-derived neuroectoderm.
Stem cell reports
Lippmann ES,Williams CE,Ruhl DA,Estevez-Silva MC,Chapman ER,Coon JJ,Ashton RS
Tue Apr 14 00:00:00 EDT 2015
A High-content screen identifies compounds promoting the neuronal differentiation and the midbrain dopamine neuron specification of human neural progenitor cells.
Scientific reports
Rhim JH,Luo X,Xu X,Gao D,Zhou T,Li F,Qin L,Wang P,Xia X,Wong ST
Fri Nov 06 00:00:00 EST 2015
Efficient specification of interneurons from human pluripotent stem cells by dorsoventral and rostrocaudal modulation.
Stem cells (Dayton, Ohio)
Kim TG,Yao R,Monnell T,Cho JH,Vasudevan A,Koh A,Peeyush KT,Moon M,Datta D,Bolshakov VY,Kim KS,Chung S
Tue Jul 01 00:00:00 EDT 2014
Prospective isolation of human embryonic stem cell-derived cardiovascular progenitors that integrate into human fetal heart tissue.
Proceedings of the National Academy of Sciences of the United States of America
Ardehali R,Ali SR,Inlay MA,Abilez OJ,Chen MQ,Blauwkamp TA,Yazawa M,Gong Y,Nusse R,Drukker M,Weissman IL
Tue Feb 26 00:00:00 EST 2013
Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix.
Proceedings of the National Academy of Sciences of the United States of America
Martino MM,Briquez PS,Ranga A,Lutolf MP,Hubbell JA
Tue Mar 19 00:00:00 EDT 2013
A global transcriptome analysis reveals molecular hallmarks of neural stem cell death, survival, and differentiation in response to partial FGF-2 and EGF deprivation.
PloS one
Nieto-Estévez V,Pignatelli J,Araúzo-Bravo MJ,Hurtado-Chong A,Vicario-Abejón C
Tue Jul 02 00:00:00 EDT 2013
Lmx1a allows context-specific isolation of progenitors of GABAergic or dopaminergic neurons during neural differentiation of embryonic stem cells.
Stem cells (Dayton, Ohio)
Nefzger CM,Su CT,Fabb SA,Hartley BJ,Beh SJ,Zeng WR,Haynes JM,Pouton CW
Sun Jul 01 00:00:00 EDT 2012
Highly pure and expandable PSA-NCAM-positive neural precursors from human ESC and iPSC-derived neural rosettes.
PloS one
Kim DS,Lee DR,Kim HS,Yoo JE,Jung SJ,Lim BY,Jang J,Kang HC,You S,Hwang DY,Leem JW,Nam TS,Cho SR,Kim DW
Fri Apr 19 00:00:00 EDT 2013
Directed expression of Gata2, Mash1, and Foxa2 synergize to induce the serotonergic neuron phenotype during in vitro differentiation of embryonic stem cells.
Stem cells (Dayton, Ohio)
Nefzger CM,Haynes JM,Pouton CW
Wed Jun 01 00:00:00 EDT 2011
Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus.
Nature communications
Devine MJ,Ryten M,Vodicka P,Thomson AJ,Burdon T,Houlden H,Cavaleri F,Nagano M,Drummond NJ,Taanman JW,Schapira AH,Gwinn K,Hardy J,Lewis PA,Kunath T
Tue Aug 23 00:00:00 EDT 2011
Transplantation of neuronal-primed human bone marrow mesenchymal stem cells in hemiparkinsonian rodents.
PloS one
Khoo ML,Tao H,Meedeniya AC,Mackay-Sim A,Ma DD
Mon Nov 28 00:00:00 EST 2011
Neural induction intermediates exhibit distinct roles of Fgf signaling.
Stem cells (Dayton, Ohio)
Sterneckert J,Stehling M,Bernemann C,Araúzo-Bravo MJ,Greber B,Gentile L,Ortmeier C,Sinn M,Wu G,Ruau D,Zenke M,Brintrup R,Klein DC,Ko K,Schöler HR
Fri Oct 01 00:00:00 EDT 2010
Fibroblast growth factor-10 promotes cardiomyocyte differentiation from embryonic and induced pluripotent stem cells.
PloS one
Chan SS,Li HJ,Hsueh YC,Lee DS,Chen JH,Hwang SM,Chen CY,Shih E,Hsieh PC
Tue Dec 28 00:00:00 EST 2010
Highly efficient and large-scale generation of functional dopamine neurons from human embryonic stem cells.
Proceedings of the National Academy of Sciences of the United States of America
Cho MS,Lee YE,Kim JY,Chung S,Cho YH,Kim DS,Kang SM,Lee H,Kim MH,Kim JH,Leem JW,Oh SK,Choi YM,Hwang DY,Chang JW,Kim DW
Tue Mar 04 00:00:00 EST 2008
Role of fibroblast growth factor 8 (FGF8) in animal models of osteoarthritis.
Arthritis research & therapy
Uchii M,Tamura T,Suda T,Kakuni M,Tanaka A,Miki I
Fri Feb 06 00:00:00 EST 2009
FGF signals from the nasal pit are necessary for normal facial morphogenesis.
Developmental biology
Szabo-Rogers HL,Geetha-Loganathan P,Nimmagadda S,Fu KK,Richman JM
Sun Jun 15 00:00:00 EDT 2008
Efficient derivation of functional dopaminergic neurons from human embryonic stem cells on a large scale.
Nature protocols
Cho MS,Hwang DY,Kim DW
Thu Jan 22 00:00:00 EST 2009
Essential role of heparan sulfate 2-O-sulfotransferase in chick limb bud patterning and development.
The Journal of biological chemistry
Kobayashi T,Habuchi H,Tamura K,Ide H,Kimata K
Fri Jul 06 00:00:00 EDT 2007
BMP and FGF regulate the differentiation of multipotential pericardial mesoderm into the myocardial or epicardial lineage.
Developmental biology
Kruithof BP,van Wijk B,Somi S,Kruithof-de Julio M,Pérez Pomares JM,Weesie F,Wessels A,Moorman AF,van den Hoff MJ
Sat Jul 15 00:00:00 EDT 2006
Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.
The Journal of biological chemistry
Zhang X,Ibrahimi OA,Olsen SK,Umemori H,Mohammadi M,Ornitz DM
Fri Jun 09 00:00:00 EDT 2006
Disruption of fibroblast growth factor signal pathway inhibits the growth of synovial sarcomas: potential application of signal inhibitors to molecular target therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research
Ishibe T,Nakayama T,Okamoto T,Aoyama T,Nishijo K,Shibata KR,Shima Y,Nagayama S,Katagiri T,Nakamura Y,Nakamura T,Toguchida J
Fri Apr 01 00:00:00 EST 2005
FGF acts directly on the somitic tendon progenitors through the Ets transcription factors Pea3 and Erm to regulate scleraxis expression.
Development (Cambridge, England)
Brent AE,Tabin CJ
Sun Aug 01 00:00:00 EDT 2004
Characterization of growth factor-binding structures in heparin/heparan sulfate using an octasaccharide library.
The Journal of biological chemistry
Ashikari-Hada S,Habuchi H,Kariya Y,Itoh N,Reddi AH,Kimata K
Fri Mar 26 00:00:00 EST 2004
Spatial and temporal expression of heparan sulfate in mouse development regulates FGF and FGF receptor assembly.
The Journal of cell biology
Allen BL,Rapraeger AC
Mon Nov 10 00:00:00 EST 2003
Heparin/Heparan sulfate domains in binding and signaling of fibroblast growth factor 8b.
The Journal of biological chemistry
Loo BM,Salmivirta M
Fri Sep 06 00:00:00 EDT 2002
