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Invitrogen
Lamin C Polyclonal Antibody
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
Product Details
PA1-5827
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Storage conditions
Shipping conditions
RRID
Product Specific Information
PA1-5827 detects Lamin C in human, rat and mouse samples.
PA1-5827 has been successfully used in immunofluorescence, Western blot and immunohistochemistry procedures. PA1-5827 reacts strongly in immunoblotting with fragments corresponding to peptide 319-572aa of Lamin C. When tested against nuclear protein extracts from HeLa cells it reacts with a single band migrating at 65 kDa.
The PA1-5827 immunogen is a synthetic peptide corresponding to the N-terminal residues K-HHVSGSRR of human lamin C, coupled to KLH.
Target Information
Lamin C is intermediate filament protein localized to the inner nuclear membrane. It is expressed predominantly in terminally differentiated cells and defines the shape and stability of nuclei in mammalian cells. Besides their structural roles, lamin proteins also regulate fundamental aspects of nuclear function and they cross-talk with cell signaling cascades and cell metabolism. Mutations of LMNA gene, encoding lamin A and C proteins, are often associated with pathogenesis of respective cell types, such as of heart myocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
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