Product References
RANKL Inhibition Reduces Cardiac Hypertrophy in mdx Mice and Possibly in Children with Duchenne Muscular Dystrophy.
Cells
Marcadet L,Juracic ES,Khan N,Bouredji Z,Yagita H,Ward LM,Tupling AR,Argaw A,Frenette J
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Western Blot
Sat Jun 03 00:00:00 EDT 2023
High-throughput longitudinal electrophysiology screening of mature chamber-specific hiPSC-CMs using optical mapping.
iScience
Allan A,Creech J,Hausner C,Krajcarski P,Gunawan B,Poulin N,Kozlowski P,Clark CW,Dow R,Saraithong P,Mair DB,Block T,Monteiro da Rocha A,Kim DH,Herron TJ
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Western Blot
Fri Jul 21 00:00:00 EDT 2023
Alterations in cytoskeletal and Ca2+ cycling regulators in atria lacking the obscurin Ig58/59 module.
Frontiers in cardiovascular medicine
Grogan A,Huang W,Brong A,Kane MA,Kontrogianni-Konstantopoulos A
MA3-919 was used in Western Blotting to implicate obscurin, particularly the Ig58/59 module, as an essential regulator of the Z-disk associated cytoskeleton and Ca2+ cycling in the atria.
Tue Jun 13 00:00:00 EDT 2023
CaMKII and reactive oxygen species contribute to early reperfusion arrhythmias, but oxidation of CaMKIIδ at methionines 281/282 is not a determining factor.
Journal of molecular and cellular cardiology
Haugsten Hansen M,Sadredini M,Hasic A,Anderson ME,Sjaastad I,Korseberg Stokke M
MA3-919 was used in Western Blotting to investigate the role of oxidized-CaMKIIδ (Ox-CaMKIIδ) in early ischemia-reperfusion arrhythmias (IRA).
Wed Feb 01 00:00:00 EST 2023
Tomatidine-stimulated maturation of human embryonic stem cell-derived cardiomyocytes for modeling mitochondrial dysfunction.
Experimental & molecular medicine
Kim YS,Yoon JW,Kim D,Choi S,Kim HK,Youm JB,Han J,Heo SC,Hyun SA,Seo JW,Kim DH,Kim JH
MA3-919 was used in Functional assay to understand the potential of tomatidine in promoting the differentiation of human embryonic stem cell-derived cardiomyocytes through mitochondrial pathways, for use in cardiotoxicity screening and cardiac disease modelling.
Fri Apr 01 00:00:00 EDT 2022
The effects of neurogranin knockdown on SERCA pump efficiency in soleus muscles of female mice fed a high fat diet.
Frontiers in endocrinology
Braun JL,Ryoo J,Goodwin K,Copeland EN,Geromella MS,Baranowski RW,MacPherson REK,Fajardo VA
MA3-919 was used in Western Blotting to show that Ng regulates SERCA pump efficiency, and future studies should further investigate the potential cellular mechanisms.
Fri Sep 09 00:00:00 EDT 2022
The effects of neurogranin knockdown on SERCA pump efficiency in soleus muscles of female mice fed a high fat diet.
Frontiers in endocrinology
Braun JL,Ryoo J,Goodwin K,Copeland EN,Geromella MS,Baranowski RW,MacPherson REK,Fajardo VA
MA3-919 was used in Western Blotting to show that Ng regulates SERCA pump efficiency, and future studies should further investigate the potential cellular mechanisms.
Fri Sep 09 00:00:00 EDT 2022
Impaired fatigue resistance, sarcoplasmic reticulum function, and mitochondrial activity in soleus muscle of db/db mice.
Physiological reports
Yamamoto H,Eshima H,Kakehi S,Kawamori R,Watada H,Tamura Y
MA3-919 was used in Western Blotting to suggest that fatigue resistance in slow-twitch dominant muscle is impaired in mice with T2DM.
Thu Sep 01 00:00:00 EDT 2022
Impaired fatigue resistance, sarcoplasmic reticulum function, and mitochondrial activity in soleus muscle of db/db mice.
Physiological reports
Yamamoto H,Eshima H,Kakehi S,Kawamori R,Watada H,Tamura Y
MA3-919 was used in Western Blotting to suggest that fatigue resistance in slow-twitch dominant muscle is impaired in mice with T2DM.
Thu Sep 01 00:00:00 EDT 2022
Low-dose lithium supplementation promotes adipose tissue browning and sarco(endo)plasmic reticulum Ca2+ ATPase uncoupling in muscle.
The Journal of biological chemistry
Geromella MS,Ryan CR,Braun JL,Finch MS,Maddalena LA,Bagshaw O,Hockey BL,Moradi F,Fenech RK,Ryoo J,Marko DM,Dhaliwal R,Sweezey-Munroe J,Hamstra SI,Gardner G,Silvera S,Vandenboom R,Roy BD,Stuart JA,MacPherson REK,Fajardo VA
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Western Blot
Tue Nov 01 00:00:00 EDT 2022
Heterozygous SOD2 deletion selectively impairs SERCA function in the soleus of female mice.
Physiological reports
Braun JL,Messner HN,Cleverdon REG,Baranowski RW,Hamstra SI,Geromella MS,Stuart JA,Fajardo VA
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Western Blot
Sun May 01 00:00:00 EDT 2022
Amniotic stromal stem cell-loaded hydrogel repairs cardiac tissue in infarcted rat hearts via paracrine mediators.
Journal of tissue engineering and regenerative medicine
Khan K,Makhoul G,Yu B,Jalani G,Derish I,Rutman AK,Cerruti M,Schwertani A,Cecere R
MA3-919 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to demonstrate the cardioprotective potential of a composite inserting human amniotic stromal mesenchymal stem cells (ASMCs) in a chitosan and hyaluronic acid (C/HA) based hydrogel in a rat MI model.
Tue Feb 01 00:00:00 EST 2022
Effects of Obesity and Diabesity on Ventricular Muscle Structure and Function in the Zucker Rat.
Life (Basel, Switzerland)
Sultan A,Adeghate E,Emerald BS,Qureshi MA,Minhas ST,Howarth FC
MA3-919 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to conclude that alterations in ventricular muscle proteins and structure may partly underlie the defects observed in Ca2+ signaling in ZDF and ZF compared to ZL rat hearts.
Thu Aug 11 00:00:00 EDT 2022
The activin receptor ligand trap ActRIIB:ALK4-Fc ameliorates cardiomyopathy induced by neuromuscular disease and diabetes.
FEBS letters
Li J,Fredericks M,Tang M,Cannell M,Joshi S,Kumar R,Andre P,Suragani RNVS
MA3-919 was used in Western Blot to explore the effects of activin ligand inhibition using ActRIIB:ALK4-Fc, a heterodimeric receptor fusion protein, in two mechanistically distinct murine models of cardiomyopathy.
Thu Dec 01 00:00:00 EST 2022
Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum.
Neuron
Kuijpers M,Kochlamazashvili G,Stumpf A,Puchkov D,Swaminathan A,Lucht MT,Krause E,Maritzen T,Schmitz D,Haucke V
MA3-919 was used in Western Blot, Immunohistochemistry to demonstrate that loss of neuronal autophagy causes selective accumulation of tubular endoplasmic reticulum (ER) in axons, resulting in increased excitatory neurotransmission and compromised postnatal viability in vivo.
Wed Jan 20 00:00:00 EST 2021
Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum.
Neuron
Kuijpers M,Kochlamazashvili G,Stumpf A,Puchkov D,Swaminathan A,Lucht MT,Krause E,Maritzen T,Schmitz D,Haucke V
MA3-919 was used in Western Blot, Immunohistochemistry to demonstrate that loss of neuronal autophagy causes selective accumulation of tubular endoplasmic reticulum (ER) in axons, resulting in increased excitatory neurotransmission and compromised postnatal viability in vivo.
Wed Jan 20 00:00:00 EST 2021
Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum.
Neuron
Kuijpers M,Kochlamazashvili G,Stumpf A,Puchkov D,Swaminathan A,Lucht MT,Krause E,Maritzen T,Schmitz D,Haucke V
MA3-919 was used in Western Blot, Immunohistochemistry to demonstrate that loss of neuronal autophagy causes selective accumulation of tubular endoplasmic reticulum (ER) in axons, resulting in increased excitatory neurotransmission and compromised postnatal viability in vivo.
Wed Jan 20 00:00:00 EST 2021
Impairment of the ER/mitochondria compartment in human cardiomyocytes with PLN p.Arg14del mutation.
EMBO molecular medicine
Cuello F,Knaust AE,Saleem U,Loos M,Raabe J,Mosqueira D,Laufer S,Schweizer M,van der Kraak P,Flenner F,Ulmer BM,Braren I,Yin X,Theofilatos K,Ruiz-Orera J,Patone G,Klampe B,Schulze T,Piasecki A,Pinto Y,Vink A,Hübner N,Harding S,Mayr M,Denning C,Eschenhagen T,Hansen A
MA3-919 was used in Immunocytochemistry to identify impairment of the ER/mitochondria compartment without SR dysfunction as a novel disease mechanism underlying PLN p.Arg14del cardiomyopathy.
Mon Jun 07 00:00:00 EDT 2021
Impairment of the ER/mitochondria compartment in human cardiomyocytes with PLN p.Arg14del mutation.
EMBO molecular medicine
Cuello F,Knaust AE,Saleem U,Loos M,Raabe J,Mosqueira D,Laufer S,Schweizer M,van der Kraak P,Flenner F,Ulmer BM,Braren I,Yin X,Theofilatos K,Ruiz-Orera J,Patone G,Klampe B,Schulze T,Piasecki A,Pinto Y,Vink A,Hübner N,Harding S,Mayr M,Denning C,Eschenhagen T,Hansen A
MA3-919 was used in Immunocytochemistry to identify impairment of the ER/mitochondria compartment without SR dysfunction as a novel disease mechanism underlying PLN p.Arg14del cardiomyopathy.
Mon Jun 07 00:00:00 EDT 2021
Compartmentation of β2 -adrenoceptor stimulated cAMP responses by phosphodiesterase types 2 and 3 in cardiac ventricular myocytes.
British journal of pharmacology
Rudokas MW,Post JP,Sataray-Rodriguez A,Sherpa RT,Moshal KS,Agarwal SR,Harvey RD
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Immunocytochemistry
Thu Apr 01 00:00:00 EDT 2021
Compartmentation of β2 -adrenoceptor stimulated cAMP responses by phosphodiesterase types 2 and 3 in cardiac ventricular myocytes.
British journal of pharmacology
Rudokas MW,Post JP,Sataray-Rodriguez A,Sherpa RT,Moshal KS,Agarwal SR,Harvey RD
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Immunocytochemistry
Thu Apr 01 00:00:00 EDT 2021
Nanoenviroments of the β-Subunit of L-Type Voltage-Gated Calcium Channels in Adult Cardiomyocytes.
Frontiers in cell and developmental biology
Cruz-Garcia Y,Barkovits K,Kohlhaas M,Pickel S,Gulentz M,Heindl C,Pfeiffer K,Eder-Negrin P,Maack C,Marcus K,Kuhn M,Miranda-Laferte E
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Western Blot
Fri Jan 21 00:00:00 EST 2022
Neuronatin promotes SERCA uncoupling and its expression is altered in skeletal muscles of high-fat diet-fed mice.
FEBS letters
Braun JL,Teng ACT,Geromella MS,Ryan CR,Fenech RK,MacPherson REK,Gramolini AO,Fajardo VA
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Western Blot
Mon Nov 01 00:00:00 EDT 2021
Neuronatin promotes SERCA uncoupling and its expression is altered in skeletal muscles of high-fat diet-fed mice.
FEBS letters
Braun JL,Teng ACT,Geromella MS,Ryan CR,Fenech RK,MacPherson REK,Gramolini AO,Fajardo VA
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Western Blot
Mon Nov 01 00:00:00 EDT 2021
Maximal strength training-induced increase in efferent neural drive is not reflected in relative protein expression of SERCA.
European journal of applied physiology
Tøien T,Haglo H,Nyberg SK,Rao SV,Stunes AK,Mosti MP,Wang E
MA3-919 was used in Western Blot to show that MST increased efferent neural drive to maximally contracting skeletal muscle, causing improved force production.
Wed Dec 01 00:00:00 EST 2021
Maximal strength training-induced increase in efferent neural drive is not reflected in relative protein expression of SERCA.
European journal of applied physiology
Tøien T,Haglo H,Nyberg SK,Rao SV,Stunes AK,Mosti MP,Wang E
MA3-919 was used in Western Blot to show that MST increased efferent neural drive to maximally contracting skeletal muscle, causing improved force production.
Wed Dec 01 00:00:00 EST 2021
Breast Cancer Promotes Cardiac Dysfunction Through Deregulation of Cardiomyocyte Ca2+-Handling Protein Expression That is Not Reversed by Exercise Training.
Journal of the American Heart Association
da Costa TSR,Urias U,Negrao MV,Jordão CP,Passos CS,Gomes-Santos IL,Salemi VMC,Camargo AA,Brum PC,Oliveira EM,Hajjar LA,Chammas R,Filho RK,Negrao CE
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Western Blot
Mon Feb 01 00:00:00 EST 2021
Breast Cancer Promotes Cardiac Dysfunction Through Deregulation of Cardiomyocyte Ca2+-Handling Protein Expression That is Not Reversed by Exercise Training.
Journal of the American Heart Association
da Costa TSR,Urias U,Negrao MV,Jordão CP,Passos CS,Gomes-Santos IL,Salemi VMC,Camargo AA,Brum PC,Oliveira EM,Hajjar LA,Chammas R,Filho RK,Negrao CE
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Western Blot
Mon Feb 01 00:00:00 EST 2021
Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy.
Nature communications
Grote Beverborg N,Später D,Knöll R,Hidalgo A,Yeh ST,Elbeck Z,Silljé HHW,Eijgenraam TR,Siga H,Zurek M,Palmér M,Pehrsson S,Albery T,Bomer N,Hoes MF,Boogerd CJ,Frisk M,van Rooij E,Damle S,Louch WE,Wang QD,Fritsche-Danielson R,Chien KR,Hansson KM,Mullick AE,de Boer RA,van der Meer P
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Western Blot
Mon Aug 30 00:00:00 EDT 2021
In vitro model of ischemic heart failure using human induced pluripotent stem cell-derived cardiomyocytes.
JCI insight
Davis J,Chouman A,Creech J,Monteiro da Rocha A,Ponce-Balbuena D,Jimenez Vazquez EN,Nichols R,Lozhkin A,Madamanchi NR,Campbell KF,Herron TJ
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Western Blot
Mon May 24 00:00:00 EDT 2021
Mammalian hybrid pre-autophagosomal structure HyPAS generates autophagosomes.
Cell
Kumar S,Javed R,Mudd M,Pallikkuth S,Lidke KA,Jain A,Tangavelou K,Gudmundsson SR,Ye C,Rusten TE,Anonsen JH,Lystad AH,Claude-Taupin A,Simonsen A,Salemi M,Phinney B,Li J,Guo LW,Bradfute SB,Timmins GS,Eskelinen EL,Deretic V
MA3-919 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to reveal the origin of mammalian autophagosomal membranes - HyPAS, and show its modulation by pharmcological agents.
Wed Nov 24 00:00:00 EST 2021
Mammalian hybrid pre-autophagosomal structure HyPAS generates autophagosomes.
Cell
Kumar S,Javed R,Mudd M,Pallikkuth S,Lidke KA,Jain A,Tangavelou K,Gudmundsson SR,Ye C,Rusten TE,Anonsen JH,Lystad AH,Claude-Taupin A,Simonsen A,Salemi M,Phinney B,Li J,Guo LW,Bradfute SB,Timmins GS,Eskelinen EL,Deretic V
MA3-919 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to reveal the origin of mammalian autophagosomal membranes - HyPAS, and show its modulation by pharmcological agents.
Wed Nov 24 00:00:00 EST 2021
Loss of CASK Accelerates Heart Failure Development.
Circulation research
Mustroph J,Sag CM,Bähr F,Schmidtmann AL,Gupta SN,Dietz A,Islam MMT,Lücht C,Beuthner BE,Pabel S,Baier MJ,El-Armouche A,Sossalla S,Anderson ME,Möllmann J,Lehrke M,Marx N,Mohler PJ,Bers DM,Unsöld B,He T,Dewenter M,Backs J,Maier LS,Wagner S
MA3-919 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to suggest that loss of CASK accelerates heart failure development.
Fri Apr 16 00:00:00 EDT 2021
Beneficial Electrophysiological Effects of Rotigaptide Are Unable to Suppress Therapeutic Hypothermia-Provoked Ventricular Fibrillation in Failing Rabbit Hearts With Acute Ischemia-Reperfusion Injury.
Frontiers in physiology
Lee HL,Chang PC,Wo HT,Liu HT,Wen MS,Chou CC
MA3-919 was used in Western Blotting to investigate the electrophysiological effects of TH and rotigaptide in failing rabbit hearts with acute IR injury and determine the underlying molecular mechanisms.
Fri Oct 01 00:00:00 EDT 2021
Acute Genetic Ablation of Cardiac Sodium/Calcium Exchange in Adult Mice: Implications for Cardiomyocyte Calcium Regulation, Cardioprotection, and Arrhythmia.
Journal of the American Heart Association
Lotteau S,Zhang R,Hazan A,Grabar C,Gonzalez D,Aynaszyan S,Philipson KD,Ottolia M,Goldhaber JI
MA3-919 was used in Western Blot to study the cardiac effects of sodium-calcium exchanger removal.
Tue Sep 07 00:00:00 EDT 2021
Changes in Thyroid Hormone Signaling Mediate Cardiac Dysfunction in the Tg197 Mouse Model of Arthritis: Potential Therapeutic Implications.
Journal of clinical medicine
Ntari L,Mantzouratou P,Katsaouni A,Pantos C,Kollias G,Mourouzis I
MA3-919 was used in Immunohistochemistry-immunofluorescence to investigate possible causes of cardiac dysfunction related to thyroid hormone (TH) signaling in a Rheumatoid Arthritis mouse model.
Thu Nov 25 00:00:00 EST 2021
Myocardial MMP-2 contributes to SERCA2a proteolysis during cardiac ischaemia-reperfusion injury.
Cardiovascular research
Roczkowsky A,Chan BYH,Lee TYT,Mahmud Z,Hartley B,Julien O,Armanious G,Young HS,Schulz R
MA3-919 was used in Western Blotting to study the role if matrix metalloproteinase-2 during cardiac contractile dysfunction specifically through action within the sarcoplasmic reticulum using rat models.
Wed Apr 01 00:00:00 EDT 2020
Distinct features of calcium handling and β-adrenergic sensitivity in heart failure with preserved versus reduced ejection fraction.
The Journal of physiology
Kilfoil PJ,Lotteau S,Zhang R,Yue X,Aynaszyan S,Solymani RE,Cingolani E,Marbán E,Goldhaber JI
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Western Blot
Sun Nov 01 00:00:00 EDT 2020
Exercise Training Stabilizes RyR2-Dependent Ca2+ Release in Post-infarction Heart Failure.
Frontiers in cardiovascular medicine
Danielsen TK,Sadredini M,Manotheepan R,Aronsen JM,Frisk M,Hansen MH,Andressen KW,Hougen K,Levy FO,Louch WE,Sejersted OM,Sjaastad I,Stokke MK
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Western Blot
Fri Feb 12 00:00:00 EST 2021
Exercise Training Stabilizes RyR2-Dependent Ca2+ Release in Post-infarction Heart Failure.
Frontiers in cardiovascular medicine
Danielsen TK,Sadredini M,Manotheepan R,Aronsen JM,Frisk M,Hansen MH,Andressen KW,Hougen K,Levy FO,Louch WE,Sejersted OM,Sjaastad I,Stokke MK
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Western Blot
Fri Feb 12 00:00:00 EST 2021
Long-term effects of empagliflozin on excitation-contraction-coupling in human induced pluripotent stem cell cardiomyocytes.
Journal of molecular medicine (Berlin, Germany)
Pabel S,Reetz F,Dybkova N,Shomroni O,Salinas G,Mustroph J,Hammer KP,Hasenfuss G,Hamdani N,Maier LS,Streckfuss-Bömeke K,Sossalla S
MA3-919 was used in Western Blotting to investigate the long-term effects (up to 2 months) of empagliflozin on excitation-contraction (EC)-coupling in human cardiomyocytes derived from induced pluripotent stem cells (iPSC-CM) in a blinded manner.
Tue Dec 01 00:00:00 EST 2020
Long-term effects of empagliflozin on excitation-contraction-coupling in human induced pluripotent stem cell cardiomyocytes.
Journal of molecular medicine (Berlin, Germany)
Pabel S,Reetz F,Dybkova N,Shomroni O,Salinas G,Mustroph J,Hammer KP,Hasenfuss G,Hamdani N,Maier LS,Streckfuss-Bömeke K,Sossalla S
MA3-919 was used in Western Blotting to investigate the long-term effects (up to 2 months) of empagliflozin on excitation-contraction (EC)-coupling in human cardiomyocytes derived from induced pluripotent stem cells (iPSC-CM) in a blinded manner.
Tue Dec 01 00:00:00 EST 2020
Age-dependent changes in electrophysiology and calcium handling: implications for pediatric cardiac research.
American journal of physiology. Heart and circulatory physiology
Swift LM,Burke M,Guerrelli D,Reilly M,Ramadan M,McCullough D,Prudencio T,Mulvany C,Chaluvadi A,Jaimes R,Posnack NG
MA3-919 was used in Protein Assays and Analysis to serve as a comprehensive baseline for future studies focused on pediatric disease modeling and/or preclinical testing.
Sat Feb 01 00:00:00 EST 2020
PKCδ causes sepsis-induced cardiomyopathy by inducing mitochondrial dysfunction.
American journal of physiology. Heart and circulatory physiology
Joseph LC,Reyes MV,Lakkadi KR,Gowen BH,Hasko G,Drosatos K,Morrow JP
MA3-919 was used in Western Blotting to shows that the protein PKCδ is required for decreased cardiac contractility during sepsis.
Wed Apr 01 00:00:00 EDT 2020
Functional culture and in vitro genetic and small-molecule manipulation of adult mouse cardiomyocytes.
Communications biology
Callaghan NI,Lee SH,Hadipour-Lakmehsari S,Lee XA,Ahsan Siraj M,Driouchi A,Yip CM,Husain M,Simmons CA,Gramolini AO
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Immunocytochemistry
Mon May 11 00:00:00 EDT 2020
Functional culture and in vitro genetic and small-molecule manipulation of adult mouse cardiomyocytes.
Communications biology
Callaghan NI,Lee SH,Hadipour-Lakmehsari S,Lee XA,Ahsan Siraj M,Driouchi A,Yip CM,Husain M,Simmons CA,Gramolini AO
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Immunocytochemistry
Mon May 11 00:00:00 EDT 2020
Low-dose lithium feeding increases the SERCA2a-to-phospholamban ratio, improving SERCA function in murine left ventricles.
Experimental physiology
Hamstra SI,Kurgan N,Baranowski RW,Qiu L,Watson CJF,Messner HN,MacPherson REK,MacNeil AJ,Roy BD,Fajardo VA
MA3-919 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to suggest that low-dose lithium supplementation can improve SERCA function by increasing the SERCA2a:PLN ratio.
Wed Apr 01 00:00:00 EDT 2020
Nicotinamide Phosphoribosyltransferase (Nampt)/Nicotinamide Adenine Dinucleotide (NAD) Axis Suppresses Atrial Fibrillation by Modulating the Calcium Handling Pathway.
International journal of molecular sciences
Feng D,Xu D,Murakoshi N,Tajiri K,Qin R,Yonebayashi S,Okabe Y,Li S,Yuan Z,Aonuma K,Ieda M
MA3-919 was used in Western Blotting to demonstrates that partially deletion of Nampt facilitated HFD-induced AF through increased diastolic calcium leaks. The Nampt/NAD axis may be a potent therapeutic target for AF.
Tue Jun 30 00:00:00 EDT 2020
Intracardiac administration of ephrinA1-Fc preserves mitochondrial bioenergetics during acute ischemia/reperfusion injury.
Life sciences
Torres MJ,McLaughlin KL,Renegar RH,Valsaraj S,Whitehurst KS,Sharaf OM,Sharma UM,Horton JL,Sarathy B,Parks JC,Brault JJ,Fisher-Wellman KH,Neufer PD,Virag JAI
MA3-919 was used in Western Blotting to suggest that intracardiac injection of EphrinA1-Fc protects cardiac function by preserving cardiomyocyte structure and mitochondrial bioenergetics, thus emerging as a potential therapeutic strategy in I/R injury.
Sun Dec 15 00:00:00 EST 2019
Long-term testosterone deficiency modifies myofilament and calcium-handling proteins and promotes diastolic dysfunction in the aging mouse heart.
American journal of physiology. Heart and circulatory physiology
Ayaz O,Banga S,Heinze-Milne S,Rose RA,Pyle WG,Howlett SE
MA3-919 was used in Western Blotting to suggest that low testosterone helps promote diastolic dysfunction in the aging heart.
Mon Apr 01 00:00:00 EDT 2019
Changes in calcium channel proteins according to magnesium sulfate administration in placentas from pregnancies with pre-eclampsia or fetal growth restriction.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research
Cha HH,Hwang JR,Sung JH,Choi SJ,Oh SY,Roh CR
MA3-919 was used in Immunohistochemistry to evaluate the changes in plasma membrane Ca2+-ATPase and sarcoendoplasmic reticulum CA2+-ATPase according to the antepartal magnesium sulfate administration in the placentas from pregnancies with pre-eclampsia or fetal growth restriction.
Fri Feb 01 00:00:00 EST 2019
SERCA2a tyrosine nitration coincides with impairments in maximal SERCA activity in left ventricles from tafazzin-deficient mice.
Physiological reports
Braun JL,Hamstra SI,Messner HN,Fajardo VA
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Western Blot
Thu Aug 01 00:00:00 EDT 2019
SERCA2a tyrosine nitration coincides with impairments in maximal SERCA activity in left ventricles from tafazzin-deficient mice.
Physiological reports
Braun JL,Hamstra SI,Messner HN,Fajardo VA
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Western Blot
Thu Aug 01 00:00:00 EDT 2019
Cardiomyocyte d-dopachrome tautomerase protects against heart failure.
JCI insight
Ma Y,Su KN,Pfau D,Rao VS,Wu X,Hu X,Leng L,Du X,Piecychna M,Bedi K,Campbell SG,Eichmann A,Testani JM,Margulies KB,Bucala R,Young LH
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Western Blot
Thu Sep 05 00:00:00 EDT 2019
SLMAP3 isoform modulates cardiac gene expression and function.
PloS one
Mlynarova J,Trentin-Sonoda M,Gaisler da Silva F,Major JL,Salih M,Carneiro-Ramos MS,Tuana BS
MA3-919 was used in Western Blotting to study the role of three SLMAP isoforms in cardiac gene expression and function.
Mon Jan 13 00:00:00 EST 2020
Nanoscale reorganization of sarcoplasmic reticulum in pressure-overload cardiac hypertrophy visualized by dSTORM.
Scientific reports
Hadipour-Lakmehsari S,Driouchi A,Lee SH,Kuzmanov U,Callaghan NI,Heximer SP,Simmons CA,Yip CM,Gramolini AO
MA3-919 was used in Western Blotting to investigate the changes in the nanoscale organisation of sarcoplasmic reticulum proteins in pathological cardiac hypertrophy.
Mon May 27 00:00:00 EDT 2019
Inhibitor of Sarco/Endoplasmic Reticulum Calcium-ATPase Impairs Multiple Steps of Paramyxovirus Replication.
Frontiers in microbiology
Kumar N,Khandelwal N,Kumar R,Chander Y,Rawat KD,Chaubey KK,Sharma S,Singh SV,Riyesh T,Tripathi BN,Barua S
MA3-919 was used in Immunocytochemistry-immunoflourescence to study the regulation of virus replication by sarco/endoplasmic reticulum calcium-ATPase.
Thu Oct 01 00:00:00 EDT 2020
A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice.
eLife
Dai W,Laforest B,Tyan L,Shen KM,Nadadur RD,Alvarado FJ,Mazurek SR,Lazarevic S,Gadek M,Wang Y,Li Y,Valdivia HH,Shen L,Broman MT,Moskowitz IP,Weber CR
MA3-919 was used in Western Blotting to establish a calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice.
Thu Mar 21 00:00:00 EDT 2019
Ablation of phospholamban rescues reperfusion arrhythmias but exacerbates myocardium infarction in hearts with Ca2+/calmodulin kinase II constitutive phosphorylation of ryanodine receptors.
Cardiovascular research
Valverde CA,Mazzocchi G,Di Carlo MN,Ciocci Pardo A,Salas N,Ragone MI,Felice JI,Cely-Ortiz A,Consolini AE,Portiansky E,Mosca S,Kranias EG,Wehrens XHT,Mattiazzi A
MA3-919 was used in Western Blotting to test the hypothesis that an increase in SR Ca2+ uptake is able to attenuate reperfusion arrhythmias and cardiac injury elicited by increased RyR2-Ser2814 phosphorylation.
Fri Mar 01 00:00:00 EST 2019
Regulation of BECN1-mediated autophagy by HSPB6: Insights from a human HSPB6S10F mutant.
Autophagy
Liu GS,Zhu H,Cai WF,Wang X,Jiang M,Essandoh K,Vafiadaki E,Haghighi K,Lam CK,Gardner G,Adly G,Nicolaou P,Sanoudou D,Liang Q,Rubinstein J,Fan GC,Kranias EG
MA3-919 was used in Western Blotting to reveal a novel regulatory mechanism of heat shock protein family B [small] member 6 in cell survival through its interaction with BECN1.
Tue Feb 26 00:00:00 EST 2019
Therapeutic Benefit and Gene Network Regulation by Combined Gene Transfer of Apelin, FGF2, and SERCA2a into Ischemic Heart.
Molecular therapy : the journal of the American Society of Gene Therapy
Renaud-Gabardos E,Tatin F,Hantelys F,Lebas B,Calise D,Kunduzova O,Masri B,Pujol F,Sicard P,Valet P,Roncalli J,Chaufour X,Garmy-Susini B,Parini A,Prats AC
MA3-919 was used in Immunocytochemistry-immunoflourescence to validate the concept of combined treatment of ischaemic heart disease with apelin, FGF2, and SERCA2a and elucidate the mechanism of therapeutic benefit.
Wed Mar 07 00:00:00 EST 2018
Hexose-6-phosphate dehydrogenase controls cancer cell proliferation and migration through pleiotropic effects on the unfolded-protein response, calcium homeostasis, and redox balance.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Tsachaki M,Mladenovic N,Štambergová H,Birk J,Odermatt A
MA3-919 was used in Western Blotting to demonstrate a pivotal role of H6PD in proliferation and migratory potential of 3 human breast cancer cell lines.
Tue May 01 00:00:00 EDT 2018
Three-dimensional imaging reveals endo(sarco)plasmic reticulum-containing invaginations within the nucleoplasm of muscle.
American journal of physiology. Cell physiology
Lee SH,Hadipour-Lakmehsari S,Miyake T,Gramolini AO
MA3-919 was used in Immunocytochemistry-immunoflourescence to characterise the molecular constituents of nuclear invaginations in the nucleoplasm in HEK293 cells, murine C2C12 muscle cells, and cardiac myocytes.
Thu Mar 01 00:00:00 EST 2018
Sarcolipin deletion in mdx mice impairs calcineurin signalling and worsens dystrophic pathology.
Human molecular genetics
Fajardo VA,Chambers PJ,Juracic ES,Rietze BA,Gamu D,Bellissimo C,Kwon F,Quadrilatero J,Russell Tupling A
MA3-919 was used in Western Blotting to show that sarcolipin deletion in mdx mice impairs calcineurin signalling and worsens dystrophic pathology.
Sat Dec 01 00:00:00 EST 2018
Preconception Exposure to Fine Particulate Matter Leads to Cardiac Dysfunction in Adult Male Offspring.
Journal of the American Heart Association
Tanwar V,Adelstein JM,Grimmer JA,Youtz DJ,Katapadi A,Sugar BP,Falvo MJ,Baer LA,Stanford KI,Wold LE
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Western Blot
Tue Dec 18 00:00:00 EST 2018
Preconception Exposure to Fine Particulate Matter Leads to Cardiac Dysfunction in Adult Male Offspring.
Journal of the American Heart Association
Tanwar V,Adelstein JM,Grimmer JA,Youtz DJ,Katapadi A,Sugar BP,Falvo MJ,Baer LA,Stanford KI,Wold LE
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Western Blot
Tue Dec 18 00:00:00 EST 2018
The DWORF micropeptide enhances contractility and prevents heart failure in a mouse model of dilated cardiomyopathy.
eLife
Makarewich CA,Munir AZ,Schiattarella GG,Bezprozvannaya S,Raguimova ON,Cho EE,Vidal AH,Robia SL,Bassel-Duby R,Olson EN
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Western Blot
Tue Oct 09 00:00:00 EDT 2018
Electrical Stimulation Prevents Preferential Skeletal Muscle Myosin Loss in Steroid-Denervation Rats.
Frontiers in physiology
Yamada T,Himori K,Tatebayashi D,Yamada R,Ashida Y,Imai T,Akatsuka M,Masuda Y,Kanzaki K,Watanabe D,Wada M,Westerblad H,Lanner JT
MA3-919 was used in Western Blotting to demonstrate that electrical stimulation treatment is an effective way to prevent muscle impairments associated with loss of myosin.
Wed Sep 30 00:00:00 EDT 2020
SPEG (Striated Muscle Preferentially Expressed Protein Kinase) Is Essential for Cardiac Function by Regulating Junctional Membrane Complex Activity.
Circulation research
Quick AP,Wang Q,Philippen LE,Barreto-Torres G,Chiang DY,Beavers D,Wang G,Khalid M,Reynolds JO,Campbell HM,Showell J,McCauley MD,Scholten A,Wehrens XH
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Immunoprecipitation
Fri Jan 06 00:00:00 EST 2017
SPEG (Striated Muscle Preferentially Expressed Protein Kinase) Is Essential for Cardiac Function by Regulating Junctional Membrane Complex Activity.
Circulation research
Quick AP,Wang Q,Philippen LE,Barreto-Torres G,Chiang DY,Beavers D,Wang G,Khalid M,Reynolds JO,Campbell HM,Showell J,McCauley MD,Scholten A,Wehrens XH
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Immunoprecipitation
Fri Jan 06 00:00:00 EST 2017
Increased passive stiffness promotes diastolic dysfunction despite improved Ca2+ handling during left ventricular concentric hypertrophy.
Cardiovascular research
Røe ÅT,Aronsen JM,Skårdal K,Hamdani N,Linke WA,Danielsen HE,Sejersted OM,Sjaastad I,Louch WE
MA3-919 was used in Western Blotting to dissect the contributions of passive and active mechanisms to diastolic dysfunction in the concentrically hypertrophied heart following pressure-overload.
Tue Aug 01 00:00:00 EDT 2017
PM2.5 exposure in utero contributes to neonatal cardiac dysfunction in mice.
Environmental pollution (Barking, Essex : 1987)
Tanwar V,Adelstein JM,Grimmer JA,Youtz DJ,Sugar BP,Wold LE
MA3-919 was used in Western Blotting to examine cardiac function of neonatal mice exposed to in utero fine particulate matter.
Wed Nov 01 00:00:00 EDT 2017
High-fat diet induces protein kinase A and G-protein receptor kinase phosphorylation of β2 -adrenergic receptor and impairs cardiac adrenergic reserve in animal hearts.
The Journal of physiology
Fu Q,Hu Y,Wang Q,Liu Y,Li N,Xu B,Kim S,Chiamvimonvat N,Xiang YK
MA3919 was used in western blot to evaluate the impacts of high fat diet on the insulin-adrenergic receptor signal network in hearts
Wed Mar 15 00:00:00 EDT 2017
MG53 is dispensable for T-tubule maturation but critical for maintaining T-tubule integrity following cardiac stress.
Journal of molecular and cellular cardiology
Zhang C,Chen B,Wang Y,Guo A,Tang Y,Khataei T,Shi Y,Kutschke WJ,Zimmerman K,Weiss RM,Liu J,Benson CJ,Hong J,Ma J,Song LS
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Western Blot
Wed Nov 01 00:00:00 EDT 2017
Misregulation of calcium-handling proteins promotes hyperactivation of calcineurin-NFAT signaling in skeletal muscle of DM1 mice.
Human molecular genetics
Ravel-Chapuis A,Bélanger G,Côté J,Michel RN,Jasmin BJ
MA3-919 was used in Western Blotting to show that calcium-CnA signaling is hyperactivated in DM1 muscle and that such hyperactivation represents a beneficial compensatory adaptation to the disease.
Thu Jun 15 00:00:00 EDT 2017
Superoxide dismutase/catalase mimetic EUK-134 prevents diaphragm muscle weakness in monocrotalin-induced pulmonary hypertension.
PloS one
Himori K,Abe M,Tatebayashi D,Lee J,Westerblad H,Lanner JT,Yamada T
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Western Blot
Mon Aug 14 00:00:00 EDT 2017
Notch Inhibition Enhances Cardiac Reprogramming by Increasing MEF2C Transcriptional Activity.
Stem cell reports
Abad M,Hashimoto H,Zhou H,Morales MG,Chen B,Bassel-Duby R,Olson EN
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Western Blot
Tue Mar 14 00:00:00 EDT 2017
Notch Inhibition Enhances Cardiac Reprogramming by Increasing MEF2C Transcriptional Activity.
Stem cell reports
Abad M,Hashimoto H,Zhou H,Morales MG,Chen B,Bassel-Duby R,Olson EN
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Western Blot
Tue Mar 14 00:00:00 EDT 2017
Deregulated Ca2+ cycling underlies the development of arrhythmia and heart disease due to mutant obscurin.
Science advances
Hu LR,Ackermann MA,Hecker PA,Prosser BL,King B,O'Connell KA,Grogan A,Meyer LC,Berndsen CE,Wright NT,Jonathan Lederer W,Kontrogianni-Konstantopoulos A
Thu Jun 01 00:00:00 EDT 2017
Deregulated Ca2+ cycling underlies the development of arrhythmia and heart disease due to mutant obscurin.
Science advances
Hu LR,Ackermann MA,Hecker PA,Prosser BL,King B,O'Connell KA,Grogan A,Meyer LC,Berndsen CE,Wright NT,Jonathan Lederer W,Kontrogianni-Konstantopoulos A
Thu Jun 01 00:00:00 EDT 2017
Sarcolipin deletion exacerbates soleus muscle atrophy and weakness in phospholamban overexpressing mice.
PloS one
Fajardo VA,Gamu D,Mitchell A,Bloemberg D,Bombardier E,Chambers PJ,Bellissimo C,Quadrilatero J,Tupling AR
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Western Blot
Wed Sep 06 00:00:00 EDT 2017
Novel ecto-tagged integrins reveal their trafficking in live cells.
Nature communications
Huet-Calderwood C,Rivera-Molina F,Iwamoto DV,Kromann EB,Toomre D,Calderwood DA
MA3-919 was used in Immunocytochemistry-immunoflourescence to develop Β1 integrins carrying traceable tags in the extracellular domain; a pH-sensitive pHlourin tag or a HaloTag to facilitate dye attachment.
Mon Sep 18 00:00:00 EDT 2017
In Utero Particulate Matter Exposure Produces Heart Failure, Electrical Remodeling, and Epigenetic Changes at Adulthood.
Journal of the American Heart Association
Tanwar V,Gorr MW,Velten M,Eichenseer CM,Long VP,Bonilla IM,Shettigar V,Ziolo MT,Davis JP,Baine SH,Carnes CA,Wold LE
MA3919 was used in western blot to test if in utero particulate matter exposure alters cardiac structure and function at adulthood
Tue Apr 11 00:00:00 EDT 2017
A chemical chaperone improves muscle function in mice with a RyR1 mutation.
Nature communications
Lee CS,Hanna AD,Wang H,Dagnino-Acosta A,Joshi AD,Knoblauch M,Xia Y,Georgiou DK,Xu J,Long C,Amano H,Reynolds C,Dong K,Martin JC,Lagor WR,Rodney GG,Sahin E,Sewry C,Hamilton SL
MA3919 was used in western blot to elucidate the mechanism by which the I4895T mutation in the type 1 ryanodine receptor/Ca(2+) release channel results in disease
Fri Mar 24 00:00:00 EDT 2017
Genotype-Dependent and -Independent Calcium Signaling Dysregulation in Human Hypertrophic Cardiomyopathy.
Circulation
Helms AS,Alvarado FJ,Yob J,Tang VT,Pagani F,Russell MW,Valdivia HH,Day SM
MA3919 was used in western blot to discuss how mutations in sarcomere genes may result in altered calcium signaling and heart defects
Tue Nov 29 00:00:00 EST 2016
Mitigation of myocardial fibrosis by molecular cardiac surgery-mediated gene overexpression.
The Journal of thoracic and cardiovascular surgery
Katz MG,Brandon-Warner E,Fargnoli AS,Williams RD,Kendle AP,Hajjar RJ,Schrum LW,Bridges CR
MA3-919 was used in western blot to assess the importance of SERCA2a to the fibrotic response in small and large myocardial infarct
Fri Apr 01 00:00:00 EDT 2016
BGP-15 Improves Aspects of the Dystrophic Pathology in mdx and dko Mice with Differing Efficacies in Heart and Skeletal Muscle.
The American journal of pathology
Kennedy TL,Swiderski K,Murphy KT,Gehrig SM,Curl CL,Chandramouli C,Febbraio MA,Delbridge LM,Koopman R,Lynch GS
MA3919 was used in western blot to test if BGP-15 ameliorate established disease in a mouse model of Duchenne muscular dystrophy
Thu Dec 01 00:00:00 EST 2016
Phospholamban degradation is induced by phosphorylation-mediated ubiquitination and inhibited by interaction with cardiac type Sarco(endo)plasmic reticulum Ca(2+)-ATPase.
Biochemical and biophysical research communications
Nakagawa T,Yokoe S,Asahi M
MA3-919 was used in western blot to elucidate the induction by phosphorylation-mediated ubiquitination and inhibition by interaction with cardiac type Sarco(endo)plasmic reticulum Ca(2+)-ATPase due to phospholamban degradation
Fri Apr 08 00:00:00 EDT 2016
Gene-Targeted Mice with the Human Troponin T R141W Mutation Develop Dilated Cardiomyopathy with Calcium Desensitization.
PloS one
Ramratnam M,Salama G,Sharma RK,Wang DW,Smith SH,Banerjee SK,Huang XN,Gifford LM,Pruce ML,Gabris BE,Saba S,Shroff SG,Ahmad F
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Western Blot
Fri Jul 07 00:00:00 EDT 2017
Exercise training increases protein O-GlcNAcylation in rat skeletal muscle.
Physiological reports
Hortemo KH,Lunde PK,Anonsen JH,Kvaløy H,Munkvik M,Rehn TA,Sjaastad I,Lunde IG,Aronsen JM,Sejersted OM
MA3-919 was used in western blot determine the role of protein O-GlcNAcylation in skeletal muscle
Thu Sep 01 00:00:00 EDT 2016
Beta-Adrenoceptor Stimulation Reveals Ca2+ Waves and Sarcoplasmic Reticulum Ca2+ Depletion in Left Ventricular Cardiomyocytes from Post-Infarction Rats with and without Heart Failure.
PloS one
Sadredini M,Danielsen TK,Aronsen JM,Manotheepan R,Hougen K,Sjaastad I,Stokke MK
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Western Blot
Fri Sep 09 00:00:00 EDT 2016
The synthetic antimicrobial peptide 19-2.5 attenuates septic cardiomyopathy and prevents down-regulation of SERCA2 in polymicrobial sepsis.
Scientific reports
Martin L,Horst K,Chiazza F,Oggero S,Collino M,Brandenburg K,Hildebrand F,Marx G,Thiemermann C,Schuerholz T
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Immunofluorescence
Thu Nov 17 00:00:00 EST 2016
The synthetic antimicrobial peptide 19-2.5 attenuates septic cardiomyopathy and prevents down-regulation of SERCA2 in polymicrobial sepsis.
Scientific reports
Martin L,Horst K,Chiazza F,Oggero S,Collino M,Brandenburg K,Hildebrand F,Marx G,Thiemermann C,Schuerholz T
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Immunofluorescence
Thu Nov 17 00:00:00 EST 2016
The synthetic antimicrobial peptide 19-2.5 attenuates septic cardiomyopathy and prevents down-regulation of SERCA2 in polymicrobial sepsis.
Scientific reports
Martin L,Horst K,Chiazza F,Oggero S,Collino M,Brandenburg K,Hildebrand F,Marx G,Thiemermann C,Schuerholz T
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Immunofluorescence
Thu Nov 17 00:00:00 EST 2016
Mitochondrial aldehyde dehydrogenase protects against doxorubicin cardiotoxicity through a transient receptor potential channel vanilloid 1-mediated mechanism.
Biochimica et biophysica acta
Ge W,Yuan M,Ceylan AF,Wang X,Ren J
MA3-919 was used in western blot to determine the impact of ALDH2 overexpression on doxorubicin-induced myocardial damage and mitochondria
Fri Apr 01 00:00:00 EDT 2016
Diaphragm assessment in mice overexpressing phospholamban in slow-twitch type I muscle fibers.
Brain and behavior
Fajardo VA,Smith IC,Bombardier E,Chambers PJ,Quadrilatero J,Tupling AR
MA3-919 was used in western blot to study slow-twitch type 1 muscle fibers and diaphragm assessment in mice overexpressing phospholamban
Wed Jun 01 00:00:00 EDT 2016
Human Engineered Heart Tissue: Analysis of Contractile Force.
Stem cell reports
Mannhardt I,Breckwoldt K,Letuffe-Brenière D,Schaaf S,Schulz H,Neuber C,Benzin A,Werner T,Eder A,Schulze T,Klampe B,Christ T,Hirt MN,Huebner N,Moretti A,Eschenhagen T,Hansen A
MA3-919 was used in western blot characterize engineered heart tissues derived from human induced pluripotent stem cell-derived cardiomyocytes
Tue Jul 12 00:00:00 EDT 2016
Cardiac Effects of Attenuating Gsα - Dependent Signaling.
PloS one
Streit MR,Weiss CS,Meyer S,Ochs MM,Hagenmueller M,Riffel JH,Buss SJ,Heger T,Katus HA,Hardt SE
MA3-919 was used in Western Blotting to show that Gsα-DN-mice provide novel insights into Β-adrenergic signal transduction and its modulation in myocardial overload and failure.
Tue Jul 12 00:00:00 EDT 2016
Ca(2+) permeation and/or binding to CaV1.1 fine-tunes skeletal muscle Ca(2+) signaling to sustain muscle function.
Skeletal muscle
Lee CS,Dagnino-Acosta A,Yarotskyy V,Hanna A,Lyfenko A,Knoblauch M,Georgiou DK,Poché RA,Swank MW,Long C,Ismailov II,Lanner J,Tran T,Dong K,Rodney GG,Dickinson ME,Beeton C,Zhang P,Dirksen RT,Hamilton SL
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Western Blot
Thu Feb 26 00:00:00 EST 2015
Nitric oxide enhances extracellular ATP induced Ca²⁺ oscillation in HeLa cells.
Archives of biochemistry and biophysics
Tang Y,Yin Y,Miao L,Wei B,Zhai K,Ji G
MA3-919 was used in western blot to study the role and mechanism of nitric oxide on Ca(2+) release
Thu Jan 01 00:00:00 EST 2015
Sex Hormones Promote Opposite Effects on ACE and ACE2 Activity, Hypertrophy and Cardiac Contractility in Spontaneously Hypertensive Rats.
PloS one
Dalpiaz PL,Lamas AZ,Caliman IF,Ribeiro RF,Abreu GR,Moyses MR,Andrade TU,Gouvea SA,Alves MF,Carmona AK,Bissoli NS
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Western Blot
Mon Apr 18 00:00:00 EDT 2016
Cellular Hypertrophy and Increased Susceptibility to Spontaneous Calcium-Release of Rat Left Atrial Myocytes Due to Elevated Afterload.
PloS one
Zhang H,Cannell MB,Kim SJ,Watson JJ,Norman R,Calaghan SC,Orchard CH,James AF
MA3-919 was used in western blot to study the effects of ascending aortic banding on calcium handling in rat isolated atrial myocytes
Wed Jul 06 00:00:00 EDT 2016
Antioxidant metallothionein alleviates endoplasmic reticulum stress-induced myocardial apoptosis and contractile dysfunction.
Free radical research
Yang L,Wang J,Yang J,Schamber R,Hu N,Nair S,Xiong L,Ren J
MA3-919 was used in western blot to investigate the mechanism by which cysteine-rich free radical scavenger metallothionein regulates ER stress-induced myocardial contractile defect.
Thu Oct 01 00:00:00 EDT 2015
Early remodeling of perinuclear Ca2+ stores and nucleoplasmic Ca2+ signaling during the development of hypertrophy and heart failure.
Circulation
Ljubojevic S,Radulovic S,Leitinger G,Sedej S,Sacherer M,Holzer M,Winkler C,Pritz E,Mittler T,Schmidt A,Sereinigg M,Wakula P,Zissimopoulos S,Bisping E,Post H,Marsche G,Bossuyt J,Bers DM,Kockskämper J,Pieske B
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Immunocytochemistry
Tue Jul 15 00:00:00 EDT 2014
Early remodeling of perinuclear Ca2+ stores and nucleoplasmic Ca2+ signaling during the development of hypertrophy and heart failure.
Circulation
Ljubojevic S,Radulovic S,Leitinger G,Sedej S,Sacherer M,Holzer M,Winkler C,Pritz E,Mittler T,Schmidt A,Sereinigg M,Wakula P,Zissimopoulos S,Bisping E,Post H,Marsche G,Bossuyt J,Bers DM,Kockskämper J,Pieske B
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Immunocytochemistry
Tue Jul 15 00:00:00 EDT 2014
Early remodeling of perinuclear Ca2+ stores and nucleoplasmic Ca2+ signaling during the development of hypertrophy and heart failure.
Circulation
Ljubojevic S,Radulovic S,Leitinger G,Sedej S,Sacherer M,Holzer M,Winkler C,Pritz E,Mittler T,Schmidt A,Sereinigg M,Wakula P,Zissimopoulos S,Bisping E,Post H,Marsche G,Bossuyt J,Bers DM,Kockskämper J,Pieske B
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Immunocytochemistry
Tue Jul 15 00:00:00 EDT 2014
Double-stranded RNA-dependent protein kinase deficiency protects the heart from systolic overload-induced congestive heart failure.
Circulation
Wang H,Xu X,Fassett J,Kwak D,Liu X,Hu X,Falls TJ,Bell JC,Li H,Bitterman P,Bache RJ,Chen Y
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Western Blot
Tue Apr 01 00:00:00 EDT 2014
Progesterone modulates SERCA2a expression and function in rabbit cardiomyocytes.
American journal of physiology. Cell physiology
Moshal KS,Zhang Z,Roder K,Kim TY,Cooper L,Patedakis Litvinov B,Lu Y,Reddy V,Terentyev D,Choi BR,Koren G
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Immunoprecipitation
Mon Dec 01 00:00:00 EST 2014
Progesterone modulates SERCA2a expression and function in rabbit cardiomyocytes.
American journal of physiology. Cell physiology
Moshal KS,Zhang Z,Roder K,Kim TY,Cooper L,Patedakis Litvinov B,Lu Y,Reddy V,Terentyev D,Choi BR,Koren G
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Immunoprecipitation
Mon Dec 01 00:00:00 EST 2014
Age-associated abnormalities of intrinsic automaticity of sinoatrial nodal cells are linked to deficient cAMP-PKA-Ca(2+) signaling.
American journal of physiology. Heart and circulatory physiology
Liu J,Sirenko S,Juhaszova M,Sollott SJ,Shukla S,Yaniv Y,Lakatta EG
MA3-919 was used in western blot to study the role of Ca(2+) cycling and cAMP signaling in the age-related decline in sinoatrial node function
Thu May 15 00:00:00 EDT 2014
The beneficial effects of ranolazine on cardiac function after myocardial infarction are greater in diabetic than in nondiabetic rats.
Journal of cardiovascular pharmacology and therapeutics
Mourouzis I,Mantzouratou P,Galanopoulos G,Kostakou E,Dhalla AK,Belardinelli L,Pantos C
MA3-919 was used in western blot to study the mechanisms underlying the greater therapeutic effect of ranolazine in diabetic than in non-diabetic infarcted rat heart
Mon Sep 01 00:00:00 EDT 2014
Long term ablation of protein kinase A (PKA)-mediated cardiac troponin I phosphorylation leads to excitation-contraction uncoupling and diastolic dysfunction in a knock-in mouse model of hypertrophic cardiomyopathy.
The Journal of biological chemistry
Dweck D,Sanchez-Gonzalez MA,Chang AN,Dulce RA,Badger CD,Koutnik AP,Ruiz EL,Griffin B,Liang J,Kabbaj M,Fincham FD,Hare JM,Overton JM,Pinto JR
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Western Blot
Fri Aug 15 00:00:00 EDT 2014
Regional ion channel gene expression heterogeneity and ventricular fibrillation dynamics in human hearts.
PloS one
Sivagangabalan G,Nazzari H,Bignolais O,Maguy A,Naud P,Farid T,Massé S,Gaborit N,Varro A,Nair K,Backx P,Vigmond E,Nattel S,Demolombe S,Nanthakumar K
MA3-919 was used in western blot to study the relationship between ventricular fibrillation and the regional expression of ion channels in the myopathic heart
Fri Oct 17 00:00:00 EDT 2014
TRPV2 is critical for the maintenance of cardiac structure and function in mice.
Nature communications
Katanosaka Y,Iwasaki K,Ujihara Y,Takatsu S,Nishitsuji K,Kanagawa M,Sudo A,Toda T,Katanosaka K,Mohri S,Naruse K
MA3-919 was used in western blot to elucidate the critical role of TRPV2 in maintenance of cardiac function and structure in mice
Thu May 29 00:00:00 EDT 2014
Genetically encoded fluorescent thermosensors visualize subcellular thermoregulation in living cells.
Nature methods
Kiyonaka S,Kajimoto T,Sakaguchi R,Shinmi D,Omatsu-Kanbe M,Matsuura H,Imamura H,Yoshizaki T,Hamachi I,Morii T,Mori Y
MA3-919 was used in western blot to study subcellular thermoregulation in living cells using GFP-based thermosensors
Sun Dec 01 00:00:00 EST 2013
Characterization of the Drosophila atlastin interactome reveals VCP as a functionally related interactor.
Journal of genetics and genomics = Yi chuan xue bao
O'Sullivan NC,Dräger N,O'Kane CJ
MA3-919 was used in western blot to study the role of the VCP-atlastin interaction in Drosophila and the significance for neurodegenerative diseases
Thu Jun 20 00:00:00 EDT 2013
Impaired contractile function due to decreased cardiac myosin binding protein C content in the sarcomere.
American journal of physiology. Heart and circulatory physiology
Cheng Y,Wan X,McElfresh TA,Chen X,Gresham KS,Rosenbaum DS,Chandler MP,Stelzer JE
MA3-919 was used in western blot to study the effects of reduced MyBP-C expression on cardiac contractile function
Mon Jul 01 00:00:00 EDT 2013
Caspase 3 cleavage of the inositol 1,4,5-trisphosphate receptor does not contribute to apoptotic calcium release.
Cell calcium
Akimzhanov AM,Barral JM,Boehning D
MA3-919 was used in western blot to study whether cleavage of the inositiol1,4,5 trisphosphate receptor is a cause or an effect of apoptotic Ca(2+) release
Fri Feb 01 00:00:00 EST 2013
Diaphragm muscle remodeling in a rat model of chronic intermittent hypoxia.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Shortt CM,Fredsted A,Bradford A,O'Halloran KD
MA3-919 was used in immunohistochemistry to study the differential effects of chronic intermittent hypoxia on the remodeling of rat diaphragm and sternohyoid muscles
Mon Jul 01 00:00:00 EDT 2013
Inhibition of thyroid hormone receptor α1 impairs post-ischemic cardiac performance after myocardial infarction in mice.
Molecular and cellular biochemistry
Mourouzis I,Kostakou E,Galanopoulos G,Mantzouratou P,Pantos C
MA3-919 was used in western blot to study the deleterious effect of pharmacological inhibition of thyroid hormone receptor alpha1 on post-ischemic cardiac function in a murine model of myocardial infarction
Mon Jul 01 00:00:00 EDT 2013
In vivo imaging of intracellular Ca2+ after muscle contractions and direct Ca2+ injection in rat skeletal muscle in diabetes.
American journal of physiology. Regulatory, integrative and comparative physiology
Eshima H,Tanaka Y,Sonobe T,Inagaki T,Nakajima T,Poole DC,Kano Y
MA3-919 was used in western blot to study Ca(2+) handling in diabetic rat skeletal muscle using in vivo imaging
Sun Sep 15 00:00:00 EDT 2013
Complete atrial-specific knockout of sodium-calcium exchange eliminates sinoatrial node pacemaker activity.
PloS one
Groenke S,Larson ED,Alber S,Zhang R,Lamp ST,Ren X,Nakano H,Jordan MC,Karagueuzian HS,Roos KP,Nakano A,Proenza C,Philipson KD,Goldhaber JI
MA3-919 was used in western blot to study the elimination of sinoatrial node pacemaker activity by the complete atrial-specific ablation of NCX1
Tue Aug 05 00:00:00 EDT 2014
The effects of neuregulin on cardiac Myosin light chain kinase gene-ablated hearts.
PloS one
Chang AN,Huang J,Battiprolu PK,Hill JA,Kamm KE,Stull JT
MA3-919 was used in western blot to study the cardiac effects of neuregulin in cMLCK knockout mice
Thu Jan 16 00:00:00 EST 2014
The impact of ovariectomy on calcium homeostasis and myofilament calcium sensitivity in the aging mouse heart.
PloS one
Fares E,Pyle WG,Ray G,Rose RA,Denovan-Wright EM,Chen RP,Howlett SE
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Western Blot
Mon Jun 16 00:00:00 EDT 2014
ATP consumption by sarcoplasmic reticulum Ca²⁺ pumps accounts for 40-50% of resting metabolic rate in mouse fast and slow twitch skeletal muscle.
PloS one
Smith IC,Bombardier E,Vigna C,Tupling AR
MA3-919 was used in western blot to quantify the relative contribution of calcium cycling to resting metabolic rate in mouse fast and slow twitch skeletal muscle
Fri Feb 07 00:00:00 EST 2014
Co-expression of SERCA isoforms, phospholamban and sarcolipin in human skeletal muscle fibers.
PloS one
Fajardo VA,Bombardier E,Vigna C,Devji T,Bloemberg D,Gamu D,Gramolini AO,Quadrilatero J,Tupling AR
MA3-919 was used in immunohistochemistry - frozen section, immunoprecipitation, and western blot to determine if sarcolipin and phospholamban regulate SERCA1a, SERCA2a, or both in skeletal muscle
Tue Sep 16 00:00:00 EDT 2014
Targeted deletion of microRNA-22 promotes stress-induced cardiac dilation and contractile dysfunction.
Circulation
Gurha P,Abreu-Goodger C,Wang T,Ramirez MO,Drumond AL,van Dongen S,Chen Y,Bartonicek N,Enright AJ,Lee B,Kelm RJ,Reddy AK,Taffet GE,Bradley A,Wehrens XH,Entman ML,Rodriguez A
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Western Blot
Tue Jun 05 00:00:00 EDT 2012
Tirapazamine-doxorubicin interaction referring to heart oxidative stress and Ca²⁺ balance protein levels.
Oxidative medicine and cellular longevity
Sliwinska J,Dudka J,Korga A,Burdan F,Matysiak W,Jodlowska-Jedrych B,Mandziuk S,Dawidek-Pietryka K
MA3-919 was used in western blot to study the effect of tirapazamine on oxidative stress and heart contractile protein level in doxorubicin-treated rats
Tue Sep 04 00:00:00 EDT 2012
Estradiol promotes sudden cardiac death in transgenic long QT type 2 rabbits while progesterone is protective.
Heart rhythm
Odening KE,Choi BR,Liu GX,Hartmann K,Ziv O,Chaves L,Schofield L,Centracchio J,Zehender M,Peng X,Brunner M,Koren G
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Western Blot
Tue May 01 00:00:00 EDT 2012
Abnormalities of calcium handling proteins in skeletal muscle mirror those of the heart in humans with heart failure: a shared mechanism?
Journal of cardiac failure
Middlekauff HR,Vigna C,Verity MA,Fonarow GC,Horwich TB,Hamilton MA,Shieh P,Tupling AR
MA3-919 was used in western blot to investigate the abnormalities of calcium handling proteins in skeletal and heart muscle during heart failure
Sat Sep 01 00:00:00 EDT 2012
Differential calcium handling in two canine models of right ventricular pressure overload.
The Journal of surgical research
Moon MR,Aziz A,Lee AM,Moon CJ,Okada S,Kanter EM,Yamada KA
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Western Blot
Sat Dec 01 00:00:00 EST 2012
Augmentation of left ventricular mechanics by recirculation-mediated AAV2/1-SERCA2a gene delivery in experimental heart failure.
European journal of heart failure
Mariani JA,Smolic A,Preovolos A,Byrne MJ,Power JM,Kaye DM
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Western Blot
Tue Mar 01 00:00:00 EST 2011
Changes in myofilament proteins, but not Ca²⁺ regulation, are associated with a high-fat diet-induced improvement in contractile function in heart failure.
American journal of physiology. Heart and circulatory physiology
Cheng Y,Li W,McElfresh TA,Chen X,Berthiaume JM,Castel L,Yu X,Van Wagoner DR,Chandler MP
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Western Blot
Sat Oct 01 00:00:00 EDT 2011
Alignment of sarcoplasmic reticulum-mitochondrial junctions with mitochondrial contact points.
American journal of physiology. Heart and circulatory physiology
García-Pérez C,Schneider TG,Hajnóczky G,Csordás G
MA3-919 was used in western blot to investigate the localization of ryanodine receptor-mitochondrial calcium signaling in mitochondria
Tue Nov 01 00:00:00 EDT 2011
Role of Pyk2 in cardiac arrhythmogenesis.
American journal of physiology. Heart and circulatory physiology
Lang D,Glukhov AV,Efimova T,Efimov IR
MA3-919 was used in western blot to study the role of Pyk2 in cardiac arrhythmogenesis
Thu Sep 01 00:00:00 EDT 2011
Decrease in the density of t-tubular L-type Ca2+ channel currents in failing ventricular myocytes.
American journal of physiology. Heart and circulatory physiology
Horiuchi-Hirose M,Kashihara T,Nakada T,Kurebayashi N,Shimojo H,Shibazaki T,Sheng X,Yano S,Hirose M,Hongo M,Sakurai T,Moriizumi T,Ueda H,Yamada M
MA3-919 was used in western blot to investigate the mechanism for the decrease of the TT LTCC current density in failing ventricular myocytes
Tue Mar 01 00:00:00 EST 2011
G37R SOD1 mutant alters mitochondrial complex I activity, Ca(2+) uptake and ATP production.
Cell calcium
Coussee E,De Smet P,Bogaert E,Elens I,Van Damme P,Willems P,Koopman W,Van Den Bosch L,Callewaert G
MA3-919 was used in western blot to identify the molecular cause of ALS in superoxide dismutase mutants
Fri Apr 01 00:00:00 EDT 2011
Cardiac calcium pump inactivation and nitrosylation in senescent rat myocardium are not attenuated by long-term treadmill training.
Experimental gerontology
Thomas MM,Vigna C,Betik AC,Tupling AR,Hepple RT
MA3-919 was used in western blot to study the effect of long-term treadmill training on xardiac calcium pump inactivation and nitrosylation in senescent rat myocardium
Sat Oct 01 00:00:00 EDT 2011
D4cpv-calsequestrin: a sensitive ratiometric biosensor accurately targeted to the calcium store of skeletal muscle.
The Journal of general physiology
Sztretye M,Yi J,Figueroa L,Zhou J,Royer L,Ríos E
MA3-919 was used in immunocytochemistry to develop a new monitor of free calcium concentration in sarcoplasmic reticulum
Mon Aug 01 00:00:00 EDT 2011
Temperature dependence of cardiac sarcoplasmic reticulum Ca²⁺-ATPase from rainbow trout Oncorhynchus mykiss.
Journal of fish biology
Da Silva D,Costa DC,Alves CM,Block BA,Landeira-Fernandez AM
MA3-919 was used in western blot to study the effect of temperature on cardiac sarcoplasmic reticulum calcium-ATPase
Thu Sep 01 00:00:00 EDT 2011
Uncoupling protein 3 (UCP3) modulates the activity of Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) by decreasing mitochondrial ATP production.
The Journal of biological chemistry
De Marchi U,Castelbou C,Demaurex N
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Western Blot
Fri Sep 16 00:00:00 EDT 2011
Uncoupling protein 3 (UCP3) modulates the activity of Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) by decreasing mitochondrial ATP production.
The Journal of biological chemistry
De Marchi U,Castelbou C,Demaurex N
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Western Blot
Fri Sep 16 00:00:00 EDT 2011
Identification of secondary effects of hyperexcitability by proteomic profiling of myotonic mouse muscle.
Molecular bioSystems
Staunton L,Jockusch H,Wiegand C,Albrecht T,Ohlendieck K
MA3-919 was used in western blot to identify myotonia-specific changes in protein expression in several mouse models
Mon Aug 01 00:00:00 EDT 2011
A human-specific deletion in mouse Cmah increases disease severity in the mdx model of Duchenne muscular dystrophy.
Science translational medicine
Chandrasekharan K,Yoon JH,Xu Y,deVries S,Camboni M,Janssen PM,Varki A,Martin PT
MA3-919 was used in western blot to investigate the role of Cmah mutations in Duchenne muscular dystrophy
Wed Jul 28 00:00:00 EDT 2010
Training effects on skeletal muscle calcium handling in human chronic heart failure.
Medicine and science in sports and exercise
Munkvik M,Rehn TA,Slettaløkken G,Hasic A,Hallén J,Sjaastad I,Sejersted OM,Lunde PK
MA3-919 was used in western blot to study the exercise-related skeletal muscle calcium homeostasis in normal and diseased hearts
Sat May 01 00:00:00 EDT 2010
Sodium accumulation promotes diastolic dysfunction in end-stage heart failure following Serca2 knockout.
The Journal of physiology
Louch WE,Hougen K,Mørk HK,Swift F,Aronsen JM,Sjaastad I,Reims HM,Roald B,Andersson KB,Christensen G,Sejersted OM
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Western Blot
Mon Feb 01 00:00:00 EST 2010
Cre-loxP DNA recombination is possible with only minimal unspecific transcriptional changes and without cardiomyopathy in Tg(alphaMHC-MerCreMer) mice.
American journal of physiology. Heart and circulatory physiology
Hougen K,Aronsen JM,Stokke MK,Enger U,Nygard S,Andersson KB,Christensen G,Sejersted OM,Sjaastad I
MA3-919 was used in western blot to improve the Cre-loxP DNA recombination transgenic method
Mon Nov 01 00:00:00 EDT 2010
AFos inhibits phenylephrine-mediated contractile dysfunction by altering phospholamban phosphorylation.
American journal of physiology. Heart and circulatory physiology
Jeong MY,Walker JS,Brown RD,Moore RL,Vinson CS,Colucci WS,Long CS
MA3-919 was used in western blot to investigate the effect of a Fos mutant on heart cell regulation and its mechanism
Tue Jun 01 00:00:00 EDT 2010
Thyroid hormone can favorably remodel the diabetic myocardium after acute myocardial infarction.
Molecular and cellular biochemistry
Kalofoutis C,Mourouzis I,Galanopoulos G,Dimopoulos A,Perimenis P,Spanou D,Cokkinos DV,Singh J,Pantos C
MA3-919 was used in western blot to investigate the effect of thyroid hormone on remodelling the diabetic myocardium
Wed Dec 01 00:00:00 EST 2010
Initiating treadmill training in late middle age offers modest adaptations in Ca2+ handling but enhances oxidative damage in senescent rat skeletal muscle.
American journal of physiology. Regulatory, integrative and comparative physiology
Thomas MM,Vigna C,Betik AC,Tupling AR,Hepple RT
MA3-919 was used in western blot to identify the relationship between calcium handling and muscle senescence during late middle-age training
Sat May 01 00:00:00 EDT 2010
Immunohistochemical evidence for expression of fast-twitch type sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA1) in German shepherd dogs with dilated cardiomyopathy myocardium.
Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology
Summerfield N,Peters ME,Hercock CA,Mobasheri A,Young IS
MA3-919 was used in immunohistochemistry to investigate the level of SERCA1 in dilated cardiomyopathy canine myocardium
Thu Apr 01 00:00:00 EDT 2010
Calsequestrin content and SERCA determine normal and maximal Ca2+ storage levels in sarcoplasmic reticulum of fast- and slow-twitch fibres of rat.
The Journal of physiology
Murphy RM,Larkins NT,Mollica JP,Beard NA,Lamb GD
MA3-919 was used in western blot to study the effect of calsequestrin and SERCA on calcium storage levels in the sarcoplasmic reticulum of rat muscle fibres.
Thu Jan 15 00:00:00 EST 2009
Altered contractility of skeletal muscle in mice deficient in titin's M-band region.
Journal of molecular biology
Ottenheijm CA,Hidalgo C,Rost K,Gotthardt M,Granzier H
MA3-919 was used in western blot to investigate the role of M-band region of titin in muscle contraction
Fri Oct 16 00:00:00 EDT 2009
Slowing of cardiomyocyte Ca2+ release and contraction during heart failure progression in postinfarction mice.
American journal of physiology. Heart and circulatory physiology
Mørk HK,Sjaastad I,Sejersted OM,Louch WE
MA3-919 was used in western blot to investigate the effect of the slowing of cardiomyocyte calcium release during congestive heart failure (CHF) progression
Wed Apr 01 00:00:00 EDT 2009
Impact of mitral regurgitation on left ventricular anatomic and molecular remodeling and systolic function: implication for outcome.
American journal of physiology. Heart and circulatory physiology
Pu M,Gao Z,Zhang X,Liao D,Pu DK,Brennan T,Davidson WR
MA3-919 was used in western blot to study the regulation of ventricular morphology andsystolic function by mitral regurgitation
Mon Jun 01 00:00:00 EDT 2009
Mice carrying a conditional Serca2(flox) allele for the generation of Ca(2+) handling-deficient mouse models.
Cell calcium
Andersson KB,Finsen AV,Sjåland C,Winer LH,Sjaastad I,Odegaard A,Louch WE,Wang Y,Chen J,Chien KR,Sejersted OM,Christensen G
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Western Blot
Tue Sep 01 00:00:00 EDT 2009
Ischemic preconditioning fails to confer additional protection against ischemia-reperfusion injury in the hypothyroid rat heart.
Physiological research
Mourouzis I,Dimopoulos A,Saranteas T,Tsinarakis N,Livadarou E,Spanou D,Kokkinos AD,Xinaris C,Pantos C,Cokkinos DV
MA3-919 was used in western blot to investigate the effect of ischemic preconditioning on recovery from ischemia-reperfusion injury in hypothyroid rat hearts
Tue Jun 09 00:00:00 EDT 2009
Single histidine-substituted cardiac troponin I confers protection from age-related systolic and diastolic dysfunction.
Cardiovascular research
Palpant NJ,Day SM,Herron TJ,Converso KL,Metzger JM
MA3-919 was used in western blot to investigate the role of single histidine-substituted troponin I on the protection of cardiac function in aged mice
Sat Nov 01 00:00:00 EDT 2008
Cardioprotective effect of salvianolic acid B on large myocardial infarction mediated by reversing upregulation of leptin, endothelin pathways, and abnormal expression of SERCA2a, phospholamban in rats.
Journal of ethnopharmacology
He H,Shi M,Zeng X,Yang J,Li Y,Wu L,Li L
MA3-919 was used in Western Blotting to demonstrate that an activated leptin pathway correlates with abnormal expression of sarco/endoplasmic reticulum ATPase 2a, phospholamban and an activated endothelin-reactive oxygen species system in myocardial infarction.
Thu Jun 19 00:00:00 EDT 2008
Limited functional and metabolic improvements in hypertrophic and healthy rat heart overexpressing the skeletal muscle isoform of SERCA1 by adenoviral gene transfer in vivo.
American journal of physiology. Heart and circulatory physiology
O'Donnell JM,Fields A,Xu X,Chowdhury SA,Geenen DL,Bi J
MA3-919 was used in western blot to study the effect of adenoviral SERCA1 gene transfer in vivo
Mon Dec 01 00:00:00 EST 2008
Characterization of the phospholemman knockout mouse heart: depressed left ventricular function with increased Na-K-ATPase activity.
American journal of physiology. Heart and circulatory physiology
Bell JR,Kennington E,Fuller W,Dighe K,Donoghue P,Clark JE,Jia LG,Tucker AL,Moorman JR,Marber MS,Eaton P,Dunn MJ,Shattock MJ
MA3-919 was used in western blot to study the functions of PLM in the contractile functions of the normoxic mouse heart
Fri Feb 01 00:00:00 EST 2008
Reduced expression of sarcalumenin and related Ca2+ -regulatory proteins in aged rat skeletal muscle.
Experimental gerontology
O'Connell K,Gannon J,Doran P,Ohlendieck K
MA3-919 was used in western blot to investigate the expression of sarcalumenin and related calcium-regulatory proteins in rodent skeletal muscle during aging
Wed Oct 01 00:00:00 EDT 2008
S100A1 deficiency results in prolonged ventricular repolarization in response to sympathetic activation.
General physiology and biophysics
Ackermann GE,Domenighetti AA,Deten A,Bonath I,Marenholz I,Pedrazzini T,Erne P,Heizmann CW
MA3-919 was used in western blot to investigate the role of S100A1 in normal heart function
Sun Jun 01 00:00:00 EDT 2008
Physical coupling supports the local Ca2+ transfer between sarcoplasmic reticulum subdomains and the mitochondria in heart muscle.
The Journal of biological chemistry
García-Pérez C,Hajnóczky G,Csordás G
MA3-919 was used in immunohistochemistry to study the mechanism for the calcium transport between reticulum subdomains and the mitochondria
Fri Nov 21 00:00:00 EST 2008
Physical coupling supports the local Ca2+ transfer between sarcoplasmic reticulum subdomains and the mitochondria in heart muscle.
The Journal of biological chemistry
García-Pérez C,Hajnóczky G,Csordás G
MA3-919 was used in immunohistochemistry to study the mechanism for the calcium transport between reticulum subdomains and the mitochondria
Fri Nov 21 00:00:00 EST 2008
Abrupt changes in FKBP12.6 and SERCA2a expression contribute to sudden occurrence of ventricular fibrillation on reperfusion and are prevented by CPU86017.
Acta pharmacologica Sinica
Na T,Huang ZJ,Dai DZ,Zhang Y,Dai Y
MA3-919 was used in western blot to investigate the relationship between the rapid occurrence of ventricular fibrillation and abrupt changes of SERCA2a expression
Fri Jun 01 00:00:00 EDT 2007
Increased cardiomyocyte function and Ca2+ transients in mice during early congestive heart failure.
Journal of molecular and cellular cardiology
Mørk HK,Sjaastad I,Sande JB,Periasamy M,Sejersted OM,Louch WE
MA3-919 was used in western blot to investigate the myocardial function in a mouse model of early congestive heart failure
Wed Aug 01 00:00:00 EDT 2007
Thiol-oxidant monochloramine mobilizes intracellular Ca2+ in parietal cells of rabbit gastric glands.
American journal of physiology. Cell physiology
Walsh BM,Naik HB,Dubach JM,Beshire M,Wieland AM,Soybel DI
MA3-919 was used in western blot to study the effect of monochloramine on intracellular Ca2+ mobilization in rabbit parietal cells
Thu Nov 01 00:00:00 EDT 2007
Thyroid hormone attenuates cardiac remodeling and improves hemodynamics early after acute myocardial infarction in rats.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
Pantos C,Mourouzis I,Markakis K,Dimopoulos A,Xinaris C,Kokkinos AD,Panagiotou M,Cokkinos DV
MA3-919 was used in western blot to investigate the role of thyroid hormone on cardiac remodeling and myocardial performance in rat
Wed Aug 01 00:00:00 EDT 2007
Endothelin receptor antagonist CPU0213 suppresses ventricular fibrillation in L-thyroxin induced cardiomyopathy.
Pharmacological reports : PR
Feng Y,Dai DZ,Na T,Cui B,Wang T,Zhang Y,Dai Y
MA3-919 was used in western blot to investigate the influence of endothelin receptor antagonist CPU0213 on cardiomyopathy treatment induced by L-thyroxin
Thu Jan 17 00:00:00 EST 2008
Disruption of the intracellular Ca2+ homeostasis in the cardiac excitation-contraction coupling is a crucial mechanism of arrhythmic toxicity in aconitine-induced cardiomyocytes.
Biochemical and biophysical research communications
Fu M,Wu M,Wang JF,Qiao YJ,Wang Z
MA3-919 was used in western blot to investigate the mechanism of arrhythmic cytotoxicity in heart cells treated with aconitine
Fri Mar 23 00:00:00 EDT 2007
Upregulation of leptin pathway correlates with abnormal expression of SERCA2a, phospholamban and the endothelin pathway in heart failure and reversal by CPU86017.
Naunyn-Schmiedeberg's archives of pharmacology
Na T,Dai DZ,Tang XY,Dai Y
MA3-919 was used in western blot to investigate the association of hyperleptinemia with expression of SERCA2a, PLB and the endothelin pathway in chronic heart failure
Thu Mar 01 00:00:00 EST 2007
Effects of congestive heart failure on Ca2+ handling in skeletal muscle during fatigue.
Circulation research
Lunde PK,Sejersted OM,Thorud HM,Tønnessen T,Henriksen UL,Christensen G,Westerblad H,Bruton J
MA3-919 was used in Western Blotting to examine the mechanisms causing soleus fibres in rats with congestive heart failure to fatigue more rapidly than in healthy rats.
Fri Jun 23 00:00:00 EDT 2006
High intracellular Na+ preserves myocardial function at low heart rates in isolated myocardium from failing hearts.
European journal of heart failure
Schillinger W,Teucher N,Christians C,Kohlhaas M,Sossalla S,Van Nguyen P,Schmidt AG,Schunck O,Nebendahl K,Maier LS,Zeitz O,Hasenfuss G
MA3-919 was used in western blot to study the relationship between the intracellular sodium concentrate and myocardial function
Wed Nov 01 00:00:00 EST 2006
Simvastatin improves left ventricular function after myocardial infarction in hypercholesterolemic rabbits by anti-inflammatory effects.
Cardiovascular research
Bauersachs J,Hiss K,Fraccarollo D,Laufs U,Ruetten H
MA3-919 was used in western blot to investigate the effects of simvastatin treatment on cardiac function after MI
Fri Dec 01 00:00:00 EST 2006
LAMP-2 deficient mice show depressed cardiac contractile function without significant changes in calcium handling.
Basic research in cardiology
Stypmann J,Janssen PM,Prestle J,Engelen MA,Kögler H,Lüllmann-Rauch R,Eckardt L,von Figura K,Landgrebe J,Mleczko A,Saftig P
MA3-919 was used in western blot to investigate the effect of LAMP-2 on cardiac contractile function and its mechanism
Sat Jul 01 00:00:00 EDT 2006
Increased phospholamban phosphorylation limits the force-frequency response in the MLP-/- mouse with heart failure.
Journal of molecular and cellular cardiology
Antoons G,Vangheluwe P,Volders PG,Bito V,Holemans P,Ceci M,Wuytack F,Caroni P,Mubagwa K,Sipido KR
MA3-919 was used in western blot to study the role of increased phospholamban phosphorylation in limiting the force-frequency response in a model of dilated cardiomyopathy
Wed Mar 01 00:00:00 EST 2006
Comparative effects of a low-carbohydrate diet and exercise plus a low-carbohydrate diet on muscle sarcoplasmic reticulum responses in males.
American journal of physiology. Cell physiology
Duhamel TA,Green HJ,Perco JG,Ouyang J
MA3-919 was used in western blot to evaluate the effect of diet and exercise on muscle sarcoplasmic reticulum responses
Sun Oct 01 00:00:00 EDT 2006
beta(2)-Adrenergic stimulation attenuates left ventricular remodeling, decreases apoptosis, and improves calcium homeostasis in a rodent model of ischemic cardiomyopathy.
The Journal of pharmacology and experimental therapeutics
Xydas S,Kherani AR,Chang JS,Klotz S,Hay I,Mutrie CJ,Moss GW,Gu A,Schulman AR,Gao D,Hu D,Wu EX,Wei C,Oz MC,Wang J
MA3-919 was used in western blot to investigate the possible improving effect of clenbuterol on left ventricular remodeling and myocardial apoptosis as well as its synergy with metoprolol
Mon May 01 00:00:00 EDT 2006
Manipulation of dietary carbohydrates after prolonged effort modifies muscle sarcoplasmic reticulum responses in exercising males.
American journal of physiology. Regulatory, integrative and comparative physiology
Duhamel TA,Perco JG,Green HJ
MA3-919 was used in western blot to study the correlation between muscle glycogen concentration with SR calcium regulation during prolonged moderate-intensity cycling exercise
Sun Oct 01 00:00:00 EDT 2006
Gene expression of the Na-Ca2+ exchanger, SERCA2a and calsequestrin after myocardial ischemia in the neonatal rabbit heart.
Biology of the neonate
Seehase M,Quentin T,Wiludda E,Hellige G,Paul T,Schiffmann H
MA3-919 was used in western blot to investigate gene and protein expression of calcium handling proteins after myocardial ischemia in neonatal rabbit heart
Tue Oct 24 00:00:00 EDT 2006
Microarray profiling of skeletal muscle sarcoplasmic reticulum proteins.
Biochimica et biophysica acta
Schulz JS,Palmer N,Steckelberg J,Jones SJ,Zeece MG
MA3-919 was used in western blot to investigate the skeletal muscle sarcoplasmic reticulum proteins through microarray analyses
Fri Sep 01 00:00:00 EDT 2006
Adenovirus-mediated overexpression of O-GlcNAcase improves contractile function in the diabetic heart.
Circulation research
Hu Y,Belke D,Suarez J,Swanson E,Clark R,Hoshijima M,Dillmann WH
MA3-919 was used in western blot to investigate the effects of excessive protein O-GlcNAcylation on calcium handling and diabetic cardiac function
Fri May 13 00:00:00 EDT 2005
Triadin overexpression stimulates excitation-contraction coupling and increases predisposition to cellular arrhythmia in cardiac myocytes.
Circulation research
Terentyev D,Cala SE,Houle TD,Viatchenko-Karpinski S,Gyorke I,Terentyeva R,Williams SC,Gyorke S
MA3-919 was used in western blot to study the functional properties of TRD in myocardial intracellular Ca handling
Fri Apr 01 00:00:00 EST 2005
Additive amelioration of left ventricular remodeling and molecular alterations by combined aldosterone and angiotensin receptor blockade after myocardial infarction.
Cardiovascular research
Fraccarollo D,Galuppo P,Schmidt I,Ertl G,Bauersachs J
MA3-919 was used in western blot to investigate the advantage of the combination of mineralocorticoid receptor antagonism and AT1 receptor blockade
Fri Jul 01 00:00:00 EDT 2005
Thyroid hormone receptors alpha1 and beta1 are downregulated in the post-infarcted rat heart: consequences on the response to ischaemia-reperfusion.
Basic research in cardiology
Pantos C,Mourouzis I,Saranteas T,Paizis I,Xinaris C,Malliopoulou V,Cokkinos DV
MA3-919 was used in western blot to investigate the function of thyroid hormone signaling in the response of heart to ischaemia-reperfusion after myocardial infarction
Thu Sep 01 00:00:00 EDT 2005
Kallikrein gene delivery improves serum glucose and lipid profiles and cardiac function in streptozotocin-induced diabetic rats.
Diabetes
Montanari D,Yin H,Dobrzynski E,Agata J,Yoshida H,Chao J,Chao L
MA3-919 was used in western blot to investigate the role of the kallikrein-kinin system in cardiac function and glucose utilization in the streptozotocin (STZ)-induced diabetic rats
Sun May 01 00:00:00 EDT 2005
Activation of GSK-3 and phosphorylation of CRMP2 in transgenic mice expressing APP intracellular domain.
The Journal of cell biology
Ryan KA,Pimplikar SW
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Western Blot
Mon Oct 24 00:00:00 EDT 2005
Dronedarone administration prevents body weight gain and increases tolerance of the heart to ischemic stress: a possible involvement of thyroid hormone receptor alpha1.
Thyroid : official journal of the American Thyroid Association
Pantos C,Mourouzis I,Malliopoulou V,Paizis I,Tzeis S,Moraitis P,Sfakianoudis K,Varonos DD,Cokkinos DV
MA3-919 was used in western blot to study the effects of the thyroid hormone recptor-alpha1 antagonist dronedarone on body weight and cardiac tolerance of ischemic stress
Sat Jan 01 00:00:00 EST 2005
Evidence that the H1-H2 domain of alpha1 subunit of (Na++K+)-ATPase participates in the regulation of cardiac contraction.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Xu KY,Takimoto E,Juang GJ,Zhang Q,Rohde H,Myers AC
MA3-919 was used in western blot to study the relationship between alpha1 H1-H2 sequence and NKA-contractile modulation
Sat Jan 01 00:00:00 EST 2005
Impaired Ca2+ handling and contraction in cardiomyocytes from mice with a dominant negative thyroid hormone receptor alpha1.
Journal of molecular and cellular cardiology
Tavi P,Sjögren M,Lunde PK,Zhang SJ,Abbate F,Vennström B,Westerblad H
MA3-919 was used in western blot to study the role of thyroid hormone receptor alpha1 in calcium homeostasis and cardiomyocyte function
Fri Apr 01 00:00:00 EST 2005
Adenovirally delivered shRNA strongly inhibits Na+-Ca2+ exchanger expression but does not prevent contraction of neonatal cardiomyocytes.
Journal of molecular and cellular cardiology
Hurtado C,Ander BP,Maddaford TG,Lukas A,Hryshko LV,Pierce GN
MA3-919 was used in western blot to study the effect of NCX1 inhibition on the contraction of neonatal cardiomyocytes
Fri Apr 01 00:00:00 EST 2005
Genetic manipulation of calcium-handling proteins in cardiac myocytes. I. Experimental studies.
American journal of physiology. Heart and circulatory physiology
Coutu P,Metzger JM
MA3-919 was used in western blot to investigate the effects of parvalbumin (Parv) expression and sarco (endo) plasmic reticulum calcium-ATPase (SERCA2a) overexpression in the presence of beta-adrenergic stimulation
Tue Feb 01 00:00:00 EST 2005
Daily exercise-induced cardioprotection is associated with changes in calcium regulatory proteins in hypertensive rats.
American journal of physiology. Heart and circulatory physiology
Collins HL,Loka AM,Dicarlo SE
MA3-919 was used in western blot to investigate the association of daily exercise-induced cardioprotection with changes in calcium regulatory proteins in hypertensive rats
Tue Feb 01 00:00:00 EST 2005
Serine 68 of phospholemman is critical in modulation of contractility, [Ca2+]i transients, and Na+/Ca2+ exchange in adult rat cardiac myocytes.
American journal of physiology. Heart and circulatory physiology
Song J,Zhang XQ,Ahlers BA,Carl LL,Wang J,Rothblum LI,Stahl RC,Mounsey JP,Tucker AL,Moorman JR,Cheung JY
MA3-919 was used in western blot to study the relationships between phosphorylation of Ser 68 and Ser 63 of PLM and cardiac contractility, calcium transients and NCX1 activity in adult rat myocytes
Sun May 01 00:00:00 EDT 2005
Inhibition of PI-3 kinase/Akt/mTOR, but not calcineurin signaling, reverses insulin-like growth factor I-induced protection against glucose toxicity in cardiomyocyte contractile function.
The Journal of endocrinology
Li SY,Fang CX,Aberle NS,Ren BH,Ceylan-Isik AF,Ren J
MA3-919 was used in western blot to study the role of PI-3 kinase/Akt/mTOR and calcineurin pathways in insulin-like growth factor I-induced protection against glucose toxicity
Thu Sep 01 00:00:00 EDT 2005
Cardiac transgenesis with the tetracycline transactivator changes myocardial function and gene expression.
Physiological genomics
McCloskey DT,Turnbull L,Swigart PM,Zambon AC,Turcato S,Joho S,Grossman W,Conklin BR,Simpson PC,Baker AJ
MA3-919 was used in western blot to investigate the possible difference in myocardium from tTA-expressing mice
Thu Jun 16 00:00:00 EDT 2005
Effects of sarcoplasmic reticulum Ca2+-ATPase overexpression in postinfarction rat myocytes.
Journal of applied physiology (Bethesda, Md. : 1985)
Ahlers BA,Song J,Wang J,Zhang XQ,Carl LL,Tadros GM,Rothblum LI,Cheung JY
MA3-919 was used in western blot to investigate the effects of overexpressed sarcoplasmic reticulum calcium-ATPase in postinfarction rat myocytes
Wed Jun 01 00:00:00 EDT 2005
Differential Ca2+ sensitivity of RyR2 mutations reveals distinct mechanisms of channel dysfunction in sudden cardiac death.
Biochemical and biophysical research communications
Thomas NL,Lai FA,George CH
MA3-919 was used in western blot to study the role of RyR2 mutations in the pathogenesis of sudden cardiac death
Fri May 27 00:00:00 EDT 2005
Metabolic and sarcoplasmic reticulum Ca2+ cycling responses in human muscle 4 days following prolonged exercise.
Canadian journal of physiology and pharmacology
Duhamel TA,Green HJ,Perco JG,Ouyang J
MA3-919 was used in western blot to investigate the metabolic and sarcoplasmic reticulum Ca2+ cycling responses in human muscle following prolonged exercise
Fri Jul 01 00:00:00 EDT 2005
A transgenic mouse model of heart failure using inducible Galpha q.
The Journal of biological chemistry
Fan G,Jiang YP,Lu Z,Martin DW,Kelly DJ,Zuckerman JM,Ballou LM,Cohen IS,Lin RZ
MA3-919 was used in western blot to investigate the role of Galphaq activation in the development of adult animal heart failure .
Fri Dec 02 00:00:00 EST 2005
Cellular mechanisms of contractile dysfunction in hibernating myocardium.
Circulation research
Bito V,Heinzel FR,Weidemann F,Dommke C,van der Velden J,Verbeken E,Claus P,Bijnens B,De Scheerder I,Stienen GJ,Sutherland GR,Sipido KR
MA3-919 was used in western blot to investigate the phenotype of reduced contractility of the hibernating myocardium
Fri Apr 02 00:00:00 EST 2004
Cardiac-specific overexpression of sarcolipin inhibits sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2a) activity and impairs cardiac function in mice.
Proceedings of the National Academy of Sciences of the United States of America
Asahi M,Otsu K,Nakayama H,Hikoso S,Takeda T,Gramolini AO,Trivieri MG,Oudit GY,Morita T,Kusakari Y,Hirano S,Hongo K,Hirotani S,Yamaguchi O,Peterson A,Backx PH,Kurihara S,Hori M,MacLennan DH
MA3-919 was used in western blot to demonstrate the effect of NF-SLN overexpression on SERCA2a activity and cardiac function.
Tue Jun 22 00:00:00 EDT 2004
Neuronal nitric oxide synthase negatively regulates xanthine oxidoreductase inhibition of cardiac excitation-contraction coupling.
Proceedings of the National Academy of Sciences of the United States of America
Khan SA,Lee K,Minhas KM,Gonzalez DR,Raju SV,Tejani AD,Li D,Berkowitz DE,Hare JM
MA3-919 was used in immunoprecipitation to investigate the effect of neuronal nitric oxide synthase on cardiac excitation-contraction coupling..
Tue Nov 09 00:00:00 EST 2004
Identification of biochemical adaptations in hyper- or hypocontractile hearts from phospholamban mutant mice by expression proteomics.
Proceedings of the National Academy of Sciences of the United States of America
Pan Y,Kislinger T,Gramolini AO,Zvaritch E,Kranias EG,MacLennan DH,Emili A
MA3-919 was used in western blot to conduct proteomic profiling in phospholamban mutant mice.
Tue Feb 24 00:00:00 EST 2004
Sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) gene silencing and remodeling of the Ca2+ signaling mechanism in cardiac myocytes.
Proceedings of the National Academy of Sciences of the United States of America
Seth M,Sumbilla C,Mullen SP,Lewis D,Klein MG,Hussain A,Soboloff J,Gill DL,Inesi G
MA3-919 was used in western blot to study the effect of SERCA gene on calcium signaling channels.
Tue Nov 23 00:00:00 EST 2004
Hematoporphyrin monomethyl ether photodynamic damage on HeLa cells by means of reactive oxygen species production and cytosolic free calcium concentration elevation.
Cancer letters
Ding X,Xu Q,Liu F,Zhou P,Gu Y,Zeng J,An J,Dai W,Li X
MA3-919 was used in western blot to investigate the mechanism for the cellular damage caused by hematoporphyrin monomethyl ether
Wed Dec 08 00:00:00 EST 2004
Transcriptional changes following restoration of SERCA2a levels in failing rat hearts.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Del Monte F,Dalal R,Tabchy A,Couget J,Bloch KD,Peterson R,Hajjar RJ
MA3-919 was used in western blot to characterize the effect of SERCA2a on transcriptional activity in failing rat hearts
Wed Sep 01 00:00:00 EDT 2004
The Na(+)-K(+)-ATPase alpha2-subunit isoform modulates contractility in the perinatal mouse diaphragm.
American journal of physiology. Cell physiology
Radzyukevich TL,Moseley AE,Shelly DA,Redden GA,Behbehani MM,Lingrel JB,Paul RJ,Heiny JA
MA3-919 was used in western blot to study the role of the sodium/potassium-ATPase alpha2-subunit isoform during muscle contraction
Mon Nov 01 00:00:00 EST 2004
Insights into cardioprotection obtained from study of cellular Ca2+ handling in myocardium of true hibernating mammals.
American journal of physiology. Heart and circulatory physiology
Yatani A,Kim SJ,Kudej RK,Wang Q,Depre C,Irie K,Kranias EG,Vatner SF,Vatner DE
MA3-919 was used in western blot to study mammalian hibernators' inborn cardioprotective functions during hibernation
Tue Jun 01 00:00:00 EDT 2004
Effects of phospholemman downregulation on contractility and [Ca(2+)]i transients in adult rat cardiac myocytes.
American journal of physiology. Heart and circulatory physiology
Mirza MA,Zhang XQ,Ahlers BA,Qureshi A,Carl LL,Song J,Tucker AL,Mounsey JP,Moorman JR,Rothblum LI,Zhang TS,Cheung JY
MA3-919 was used in western blot to investigate the contribution of PLM downregulation to cardiac myocyte contraction, calcium transient dynamics and sodium/calcium exchanger function in adult rat cardiac myocytes
Thu Apr 01 00:00:00 EST 2004
Sprint training improves contractility in postinfarction rat myocytes: role of Na+/Ca2+ exchange.
Journal of applied physiology (Bethesda, Md. : 1985)
Song J,Zhang XQ,Wang J,Carl LL,Ahlers BA,Rothblum LI,Cheung JY
MA3-919 was used in western blot to investigate the possible effect of the reduction of NCX1 activity on contractility in myocytes isolated from sedentary rat hearts 9-11 wk after coronary artery ligation and the improving effect of HIST on contracti
Sun Aug 01 00:00:00 EDT 2004
Expression of calcium transporters in the retina of the tiger salamander (Ambystoma tigrinum).
The Journal of comparative neurology
Krizaj D,Liu X,Copenhagen DR
MA3-919 was used in immunohistochemistry to investigate how cytoplasmic free calcium in neurons from the salamander retina is regulated
Mon Aug 02 00:00:00 EDT 2004
Regional alterations in protein expression in the dyssynchronous failing heart.
Circulation
Spragg DD,Leclercq C,Loghmani M,Faris OP,Tunin RS,DiSilvestre D,McVeigh ER,Tomaselli GF,Kass DA
MA3-919 was used in western blot to examine the regional changes in protein expression during heart failure
Tue Aug 26 00:00:00 EDT 2003
Additive improvement of left ventricular remodeling and neurohormonal activation by aldosterone receptor blockade with eplerenone and ACE inhibition in rats with myocardial infarction.
Journal of the American College of Cardiology
Fraccarollo D,Galuppo P,Hildemann S,Christ M,Ertl G,Bauersachs J
MA3-919 was used in western blot to investigate the role of the aldosterone blocker eplerenone and ACE inhibition in rats with myocardial infarction
Wed Nov 05 00:00:00 EST 2003
Mechanical load-dependent regulation of gene expression in monocrotaline-induced right ventricular hypertrophy in the rat.
Circulation research
Kögler H,Hartmann O,Leineweber K,Nguyen van P,Schott P,Brodde OE,Hasenfuss G
MA3-919 was used in western blot to investigate the effects of increased mechanical load on the regulation of gene expression in the myocardium
Fri Aug 08 00:00:00 EDT 2003
Isometric force and endurance in skeletal muscle of mice devoid of all known thyroid hormone receptors.
The Journal of physiology
Johansson C,Lunde PK,Gothe S,Lannergren J,Westerblad H
MA3-919 was used in western blot to investigate the isometric force and endurance in the muscles of mice deficient in TRalpha1 or TRbeta.
Sat Mar 15 00:00:00 EST 2003
Mechanisms underlying increases in SR Ca2+-ATPase activity after exercise in rat skeletal muscle.
American journal of physiology. Endocrinology and metabolism
Schertzer JD,Green HJ,Duhamel TA,Tupling AR
MA3-919 was used in western blot to investigate the mechanism for the increase in SR calcium-ATPase activity after exercise in rat skeletal muscle
Sat Mar 01 00:00:00 EST 2003
Effect of tachycardia on myocardial sarcoplasmic reticulum and Ca2+ dynamics: a mechanism for preconditioning?
Journal of molecular and cellular cardiology
Domenech RJ,Sánchez G,Donoso P,Parra V,Macho P
MA3-919 was used in western blot to study the effect of earlier tachycardia on infarct size
Mon Dec 01 00:00:00 EST 2003
Gender differences in sarcoplasmic reticulum calcium loading after isoproterenol.
American journal of physiology. Heart and circulatory physiology
Chen J,Petranka J,Yamamura K,London RE,Steenbergen C,Murphy E
MA3-919 was used in western blot to study the possible relationship between SR calcium loading after isoproterenol and gender as well as its correlation with gender differences in ischemia-reperfusion injury
Mon Dec 01 00:00:00 EST 2003
Increased susceptibility to ventricular arrhythmias is associated with changes in Ca2+ regulatory proteins in paraplegic rats.
American journal of physiology. Heart and circulatory physiology
Rodenbaugh DW,Collins HL,Nowacek DG,DiCarlo SE
MA3-919 was used in western blot to study the effect of calcium regulatory proteins on ventricular arrhythmias in paraplegic rats
Mon Dec 01 00:00:00 EST 2003
Cardiac excitation-contraction coupling in the absence of Na(+) - Ca2+ exchange.
Cell calcium
Reuter H,Henderson SA,Han T,Mottino GA,Frank JS,Ross RS,Goldhaber JI,Philipson KD
MA3-919 was used in western blot to investigate the effect of sodium-calcium exchange on cardiac excitation-contraction coupling
Tue Jul 01 00:00:00 EDT 2003
Ca2+ regulatory systems in rat myocardium are altered by 24 weeks treadmill training.
Pflugers Archiv : European journal of physiology
Morán M,Saborido A,Megías A
MA3-919 was used in western blot to investigate the effect of 24-week treadmill training on the calcium regulatory systems in rat myocardium
Thu May 01 00:00:00 EDT 2003
Paradoxical effects of prior activity on human sarcoplasmic reticulum Ca2+-ATPase response to exercise.
Journal of applied physiology (Bethesda, Md. : 1985)
Tupling AR,Green HJ,Roy BD,Grant S,Ouyang J
MA3-919 was used in western blot to investigate the influence of exercise on SERCA function in human muscle
Tue Jul 01 00:00:00 EDT 2003
Atrial chamber-specific expression of sarcolipin is regulated during development and hypertrophic remodeling.
The Journal of biological chemistry
Minamisawa S,Wang Y,Chen J,Ishikawa Y,Chien KR,Matsuoka R
MA3-919 was used in western blot to examine the effects of development and cardiac hypertrophy on the sarcolipin expression in heart.
Fri Mar 14 00:00:00 EST 2003
Downregulation of myocardial myocyte enhancer factor 2C and myocyte enhancer factor 2C-regulated gene expression in diabetic patients with nonischemic heart failure.
Circulation
Razeghi P,Young ME,Cockrill TC,Frazier OH,Taegtmeyer H
MA3-919 was used in western blot to compare metabolic gene expression in nonischemic failing hearts of diabetic patients with that in nonischemic failing hearts of nondiabetic patients
Tue Jul 23 00:00:00 EDT 2002
Developmental changes of Ca(2+) handling in mouse ventricular cells from early embryo to adulthood.
Life sciences
Liu W,Yasui K,Opthof T,Ishiki R,Lee JK,Kamiya K,Yokota M,Kodama I
MA3-919 was used in western blot to investigate the calcium handling in cardiomyocytes throughout murine development
Fri Aug 02 00:00:00 EDT 2002
Cardiac remodeling and atrial fibrillation in transgenic mice overexpressing junctin.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Hong CS,Cho MC,Kwak YG,Song CH,Lee YH,Lim JS,Kwon YK,Chae SW,Kim DH
MA3-919 was used in western blot to study junctin's functions in heart
Thu Aug 01 00:00:00 EDT 2002
Effects of Na(+)/Ca(2+) exchanger downregulation on contractility and [Ca(2+)](i) transients in adult rat myocytes.
American journal of physiology. Heart and circulatory physiology
Tadros GM,Zhang XQ,Song J,Carl LL,Rothblum LI,Tian Q,Dunn J,Lytton J,Cheung JY
MA3-919 was used in western blot to study the role of NCX1 in adult rat myocytes
Tue Oct 01 00:00:00 EDT 2002
Overexpression of phospholemman alters contractility and [Ca(2+)](i) transients in adult rat myocytes.
American journal of physiology. Heart and circulatory physiology
Song J,Zhang XQ,Carl LL,Qureshi A,Rothblum LI,Cheung JY
MA3-919 was used in western blot to study how PLM overexpression affects contractile function and cytosolic calcium concentration homeostasis in normal adult rat cardiac myocytes
Thu Aug 01 00:00:00 EDT 2002
Interaction between increased SERCA2a activity and beta -adrenoceptor stimulation in adult rabbit myocytes.
American journal of physiology. Heart and circulatory physiology
Chaudhri B,Del Monte F,Hajjar RJ,Harding SE
MA3-919 was used in western blot to study the interaction of increased SERCA2a activity with beta-adrenoceptor stimulation in rabbit myocytes
Sun Dec 01 00:00:00 EST 2002
Alterations of beta-adrenergic signaling and cardiac hypertrophy in transgenic mice overexpressing TGF-beta(1).
American journal of physiology. Heart and circulatory physiology
Rosenkranz S,Flesch M,Amann K,Haeuseler C,Kilter H,Seeland U,Schlüter KD,Böhm M
MA3-919 was used in western blot to investigate the role of transforming growth factor-beta 1 in beta-adrenergic signaling and cardiac hypertrophy
Sun Sep 01 00:00:00 EDT 2002
Effects of moderate heart failure and functional overload on rat plantaris muscle.
Journal of applied physiology (Bethesda, Md. : 1985)
Spangenburg EE,Lees SJ,Otis JS,Musch TI,Talmadge RJ,Williams JH
MA3-919 was used in western blot to characterize the changes of rat plantaris muscles caused by moderate heart failure and functional overload
Tue Jan 01 00:00:00 EST 2002
Effects of sprint training on contractility and [Ca(2+)](i) transients in adult rat myocytes.
Journal of applied physiology (Bethesda, Md. : 1985)
Zhang XQ,Song J,Carl LL,Shi W,Qureshi A,Tian Q,Cheung JY
MA3-919 was used in western blot to investigate the effects of sprint training on contractility and calcium transients in adult rat myocytes
Tue Oct 01 00:00:00 EDT 2002
Betam, a structural member of the X,K-ATPase beta subunit family, resides in the ER and does not associate with any known X,K-ATPase alpha subunit.
Biochemistry
Crambert G,Béguin P,Pestov NB,Modyanov NN,Geering K
MA3-919 was used in immunoprecipitation to investigate the biosynthesis, processing and functions of betam
Tue May 28 00:00:00 EDT 2002
Sarcolipin inhibits polymerization of phospholamban to induce superinhibition of sarco(endo)plasmic reticulum Ca2+-ATPases (SERCAs).
The Journal of biological chemistry
Asahi M,Kurzydlowski K,Tada M,MacLennan DH
MA3-919 was used in immunoprecipitation to investigate the role of sarcolipin during the regulation of phospholamban and sarco(endo)plasmic reticulum calcium-ATPases in cardiac and slowtwitch skeletal muscles.
Fri Jul 26 00:00:00 EDT 2002
Sarcolipin overexpression in rat slow twitch muscle inhibits sarcoplasmic reticulum Ca2+ uptake and impairs contractile function.
The Journal of biological chemistry
Tupling AR,Asahi M,MacLennan DH
MA3-919 was used in immunocytochemistry to show that NF-SLN expression inhibits sarcoplasmic reticulum calcium uptake and impairs contractile function.
Fri Nov 22 00:00:00 EST 2002
Improvement in survival and cardiac metabolism after gene transfer of sarcoplasmic reticulum Ca(2+)-ATPase in a rat model of heart failure.
Circulation
del Monte F,Williams E,Lebeche D,Schmidt U,Rosenzweig A,Gwathmey JK,Lewandowski ED,Hajjar RJ
Published figure using SERCA2 ATPase monoclonal antibody (Product # MA3-919) in Western Blot
Tue Sep 18 00:00:00 EDT 2001
Contraction and intracellular Ca(2+) handling in isolated skeletal muscle of rats with congestive heart failure.
Circulation research
Lunde PK,Dahlstedt AJ,Bruton JD,Lännergren J,Thorén P,Sejersted OM,Westerblad H
MA3-919 was used in western blot to study the contraction and intracellular calcium handling in rat skeletal muscle
Fri Jun 22 00:00:00 EDT 2001
Tight control of exogenous SERCA expression is required to obtain acceleration of calcium transients with minimal cytotoxic effects in cardiac myocytes.
Circulation research
O'Donnell JM,Sumbilla CM,Ma H,Farrance IK,Cavagna M,Klein MG,Inesi G
MA3-919 was used in western blot to study the effects of exogenous SERCA expression on calcium transients in cultured cardiac myocytes
Fri Mar 02 00:00:00 EST 2001
Overexpression of Na+/Ca2+ exchanger alters contractility and SR Ca2+ content in adult rat myocytes.
American journal of physiology. Heart and circulatory physiology
Zhang XQ,Song J,Rothblum LI,Lun M,Wang X,Ding F,Dunn J,Lytton J,McDermott PJ,Cheung JY
MA3-919 was used in western blot to investigate the effects of sodium/calcium exchanger overexpression on myocyte contractility and SR calcium content in adult rat
Thu Nov 01 00:00:00 EST 2001
Gene expression of SERCA2a and L- and T-type Ca channels during human heart development.
Pediatric research
Qu Y,Boutjdir M
MA3-919 was used in Western Blotting to show that T-type Ca channel alpha(1H) subunit mRNA decreased and that L-type Ca channel alpha(1C) subunit mRNA increased with development.
Thu Nov 01 00:00:00 EST 2001
Sarco/endoplasmic reticulum calcium ATPase-2 expression is regulated by ATF6 during the endoplasmic reticulum stress response: intracellular signaling of calcium stress in a cardiac myocyte model system.
The Journal of biological chemistry
Thuerauf DJ,Hoover H,Meller J,Hernandez J,Su L,Andrews C,Dillmann WH,McDonough PM,Glembotski CC
MA3-919 was used in western blot to study the regulation of SERCA2 expression by ATF6.
Fri Dec 21 00:00:00 EST 2001
Restoration of diastolic function in senescent rat hearts through adenoviral gene transfer of sarcoplasmic reticulum Ca(2+)-ATPase.
Circulation
Schmidt U,del Monte F,Miyamoto MI,Matsui T,Gwathmey JK,Rosenzweig A,Hajjar RJ
MA3-919 was used in western blot to investigate the possible relationship between the restoration of the SR calcium-ATPase through adenoviral gene transfer in the aging heart and the normalization of diastolic function in vivo
Tue Feb 22 00:00:00 EST 2000
Chronic therapy with an ET(A/B) receptor antagonist in conscious dogs during progression of congestive heart failure. Intracellular Ca(2+) regulation and nitric oxide mediated coronary relaxation.
Cardiovascular research
Shen YT,Buie PS,Lynch JJ,Krause SM,Ma XL
MA3-919 was used in western blot to investigate the effects of ET (A/B) receptor antagonist in conscious dogs during progression of congestive heart failure
Wed Nov 01 00:00:00 EST 2000
Sprint training normalizes Ca(2+) transients and SR function in postinfarction rat myocytes.
Journal of applied physiology (Bethesda, Md. : 1985)
Zhang LQ,Zhang XQ,Ng YC,Rothblum LI,Musch TI,Moore RL,Cheung JY
MA3-919 was used in western blot to investigate the effect of sprint training on calcium regulation and sarcoplasmic reticulum (SR) function in postinfarction rat myocytes
Sat Jul 01 00:00:00 EDT 2000
Long-chain acylcarnitine induces Ca2+ efflux from the sarcoplasmic reticulum.
Journal of cardiovascular pharmacology
Yamada KA,Kanter EM,Newatia A
MA3-919 was used in western blot to investigate the role of long-chain acylcarnitine on caclium efflux from the sarcoplasmic reticulum
Sat Jul 01 00:00:00 EDT 2000
Enhanced sarcoplasmic reticulum Ca(2+) release following intermittent sprint training.
American journal of physiology. Regulatory, integrative and comparative physiology
Ortenblad N,Lunde PK,Levin K,Andersen JL,Pedersen PK
MA3-919 was used in western blot to study how intermittent sprint training affects sarcoplasmic reticulum functions
Sat Jul 01 00:00:00 EDT 2000
Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, I: experimental studies.
Circulation research
O'Rourke B,Kass DA,Tomaselli GF,Kääb S,Tunin R,Marbán E
MA3-919 was used in western blot to demonstrate that the mechanisms of altered excitation-contraction coupling in canine are similar to those reported in human heart failure
Fri Mar 19 00:00:00 EST 1999
In situ SR function in postinfarction myocytes.
Journal of applied physiology (Bethesda, Md. : 1985)
Zhang XQ,Ng YC,Moore RL,Musch TI,Cheung JY
MA3-919 was used in western blot to investigate the function of sarcoplasmic reticulum (SR) in moderate myocardial infarction (MI) myocytes
Wed Dec 01 00:00:00 EST 1999
Protein modification during biological aging: selective tyrosine nitration of the SERCA2a isoform of the sarcoplasmic reticulum Ca2+-ATPase in skeletal muscle.
The Biochemical journal
Viner RI,Ferrington DA,Williams TD,Bigelow DJ,Schöneich C
MA3-919 was used in western blot to investigate the modification of SERCA1 and SERCA2a related to aging in rat skeletal muscle
Tue Jun 15 00:00:00 EDT 1999
Alterations in sarcoplasmic reticulum function and gene expression in ischemic-reperfused rat heart.
The American journal of physiology
Temsah RM,Netticadan T,Chapman D,Takeda S,Mochizuki S,Dhalla NS
MA3-919 was used in western blot to determine the SERCA2a expression in ischemic-reperfused rat heart
Sun Aug 01 00:00:00 EDT 1999
Regional alterations in SR Ca(2+)-ATPase, phospholamban, and HSP-70 expression in chronic hibernating myocardium.
The American journal of physiology
Fallavollita JA,Jacob S,Young RF,Canty JM
MA3-919 was used in western blot to investigate the expression changes of sarcoplasmic reticulum calcium-ATPase, phospholamban, and HSP-70 in chronic hibernating myocardium
Fri Oct 01 00:00:00 EDT 1999
In vivo phosphorylation of cardiac troponin I by protein kinase Cbeta2 decreases cardiomyocyte calcium responsiveness and contractility in transgenic mouse hearts.
The Journal of clinical investigation
Takeishi Y,Chu G,Kirkpatrick DM,Li Z,Wakasaki H,Kranias EG,King GL,Walsh RA
MA3-919 was used in western blot to investigate the mechanism underlying depressed cardiac function caused by PKC beta 2-mediated phosphorylation
Wed Jul 01 00:00:00 EDT 1998
Purified, reconstituted cardiac Ca2+-ATPase is regulated by phospholamban but not by direct phosphorylation with Ca2+/calmodulin-dependent protein kinase.
The Journal of biological chemistry
Reddy LG,Jones LR,Pace RC,Stokes DL
MA3-919 was used in western blot to investigate the mechanism for the effect of phospholamban on cardiac calcium ATPase
Fri Jun 21 00:00:00 EDT 1996
Consequences of functional expression of the plasma membrane Ca2+ pump isoform 1a.
The Journal of biological chemistry
Liu BF,Xu X,Fridman R,Muallem S,Kuo TH
MA3-919 was used in western blot to detect the over-expression of plasma membrane calcium pump (PMCA) isoform 1a in RAEC
Fri Mar 08 00:00:00 EST 1996
Ca(2+)-transporting ATPase, phospholamban, and calsequestrin levels in nonfailing and failing human myocardium.
Circulation
Movsesian MA,Karimi M,Green K,Jones LR
MA3-919 was used in western blot to investigate the expression of SERCA2 ATPase, calsequestrin and phospholamban in nonfailing and failing human left ventricular myocardium
Mon Aug 01 00:00:00 EDT 1994
