Invitrogen

Caveolin 1 Monoclonal Antibody (7C8)

Advanced Verification

This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.

9 Published Figures
9 References
View all (47) Caveolin 1 antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA3-600

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200-1:2,000
View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20
-

Immunocytochemistry (ICC/IF)

1:125
View 3 publications 3 publications

Flow Cytometry (Flow)

Assay-dependent
-

Immunoprecipitation (IP)

1-3 µL
-
Product Specifications

Species Reactivity

Hamster, Human, Rat

Published species

Human, Mouse, Pig, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

7C8

Immunogen

Intercellular membrane protein-containing vesicles (containing GLUT4) from rat.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

ascites

Contains

0.05% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_779568

Product Specific Information

MA3-600 detects caveolin from human, rat and hamster samples.

MA3-600 has been successfully used in Western blot, immunofluorescence, and immunoprecipitation procedures. By Western blot, this antibody detects a 19-21 kDa band from transfected HEK293 (B8) cells, with a non-specific band appearing at 65-70 kDa.

The MA3-600 immunogen is intercellular membrane protein-containing vesicles obtained from rat.

Target Information

Caveolin-1 or CAV1 is a scaffolding proteins within caveolar membranes. It interacts directly with G-protein alpha subunits and can functionally regulate their activity. Caveolin-1 is also involved in the co-stimulatory signal essential for T-cell receptor (TCR) mediated T-cell activation. It can bind with DPP4 and induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Mutations affecting the CAV1 gene can result in congenital generalized lipodystrophy 3, pulmonary hypertension primary 3, or partial lipodystrophy/congenital cataracts, and neurodegeneration syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: caveolae; caveolin 1, caveolae protein, 22kDa; caveolin caveolae protein 22 kDa; Caveolin-1; cell growth-inhibiting protein 32; HGNC:1527; OTTHUMP00000196475

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Gene Aliases: BSCL3; CAV; CAV1; Caveolin-1; CGL3; LCCNS; MSTP085; PPH3; VIP21

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UniProt ID: (Human) Q03135

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Entrez Gene ID: (Human) 857, (Rat) 25404, (Chinese hamster) 100753021

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Function(s)
RNA polymerase I transcription factor binding receptor binding patched binding structural molecule activity protein binding cholesterol binding peptidase activator activity enzyme binding protein kinase binding syntaxin binding protein binding, bridging protein complex scaffold identical protein binding ion channel binding protein heterodimerization activity Rac GTPase binding nitric-oxide synthase binding ATPase binding inward rectifier potassium channel inhibitor activity MDM2/MDM4 family protein binding SNARE binding kinase binding scaffold/adaptor protein
Process(es)
negative regulation of transcription from RNA polymerase II promoter MAPK cascade inactivation of MAPK activity angiogenesis vasculogenesis response to hypoxia negative regulation of endothelial cell proliferation positive regulation of endothelial cell proliferation negative regulation of cytokine-mediated signaling pathway response to ischemia regulation of the force of heart contraction by chemical signal triglyceride metabolic process calcium ion transport cellular calcium ion homeostasis regulation of smooth muscle contraction skeletal muscle tissue development response to nutrient lactation protein localization response to bacterium response to gamma radiation positive regulation of calcium ion transport into cytosol posttranscriptional regulation of gene expression positive regulation of gene expression negative regulation of muscle cell apoptotic process positive regulation of peptidase activity vesicle organization receptor-mediated endocytosis of virus by host cell regulation of fatty acid metabolic process lipid storage regulation of blood coagulation cholesterol transport negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of epithelial cell differentiation mammary gland development organ regeneration positive regulation of microtubule polymerization T cell costimulation negative regulation of protein ubiquitination positive regulation of protein ubiquitination receptor internalization negative regulation of protein binding positive regulation of protein binding maintenance of protein location in cell response to progesterone negative regulation of peptidyl-serine phosphorylation positive regulation of peptidyl-serine phosphorylation cholesterol efflux nitric oxide homeostasis positive regulation of toll-like receptor 3 signaling pathway wound healing vasoconstriction response to drug negative regulation of tyrosine phosphorylation of Stat5 protein cholesterol homeostasis positive regulation of catalytic activity negative regulation of MAPK cascade response to estrogen protein localization to plasma membrane raft negative regulation of nitric oxide biosynthetic process negative regulation of neuron differentiation positive regulation of endocytosis positive regulation of vasoconstriction negative regulation of JAK-STAT cascade microtubule polymerization negative regulation of pinocytosis negative regulation of smooth muscle cell proliferation leukocyte migration regulation of nitric-oxide synthase activity negative regulation of nitric-oxide synthase activity protein homooligomerization response to glucocorticoid regulation of cytosolic calcium ion concentration response to calcium ion membrane depolarization regulation of peptidase activity calcium ion homeostasis mammary gland involution positive regulation of cell adhesion molecule production negative regulation of necroptotic process negative regulation of protein tyrosine kinase activity negative regulation of ERK1 and ERK2 cascade caveola assembly cellular response to mechanical stimulus cellular response to exogenous dsRNA cellular response to peptide hormone stimulus cellular response to hyperoxia cellular response to transforming growth factor beta stimulus caveolin-mediated endocytosis regulation of heart rate by cardiac conduction angiotensin-activated signaling pathway involved in heart process negative regulation of canonical Wnt signaling pathway positive regulation of canonical Wnt signaling pathway cellular senescence apoptotic signaling pathway regulation of membrane repolarization during action potential regulation of cardiac muscle cell action potential involved in regulation of contraction regulation of ventricular cardiac muscle cell action potential regulation of ruffle assembly negative regulation of peptidyl-tyrosine autophosphorylation negative regulation of potassium ion transmembrane transport regulation of cell communication by electrical coupling involved in cardiac conduction regulation of inward rectifier potassium channel activity positive regulation of ER-associated ubiquitin-dependent protein catabolic process protein localization to basolateral plasma membrane positive regulation of gap junction assembly beta-catenin destruction complex disassembly receptor internalization involved in canonical Wnt signaling pathway regulation of entry of bacterium into host cell negative regulation of anoikis positive regulation of extrinsic apoptotic signaling pathway positive regulation of intrinsic apoptotic signaling pathway negative regulation of cation channel activity regulation of the force of heart contraction negative regulation of cell proliferation cellular response to starvation response to mechanical stimulus positive regulation of signal transduction negative regulation of signal transduction negative regulation of BMP signaling pathway negative regulation of MAP kinase activity protein oligomerization
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