Product References
A Selective Projection from the Subthalamic Nucleus to Parvalbumin-Expressing Interneurons of the Striatum.
eNeuro
Kondabolu K,Doig NM,Ayeko O,Khan B,Torres A,Calvigioni D,Meletis K,Koós T,Magill PJ
A-21311 was used in Immunohistochemistry-immunofluorescence to show that glutamatergic striatum and subthalamic nucleus (STN) neurons are positioned to directly and powerfully influence striatal activity dynamics by virtue of their enriched innervation of GABAergic parvalbumin-expressing interneurons.
Sat Jul 01 00:00:00 EDT 2023
Channelrhodopsin fluorescent tag replacement for clinical translation of optogenetic hearing restoration.
Molecular therapy. Methods & clinical development
Zerche M,Wrobel C,Kusch K,Moser T,Mager T
A-21311 was used in Immunohistochemistry-immunofluorescence to find the replacement of the FP by the Kir2.1 trafficking sequence (TSKir2.1) to best restore both photocurrents and optogenetically evoked auditory nerve activity with only mild neural loss few months after dosing.
Thu Jun 08 00:00:00 EDT 2023
Acute liver steatosis translationally controls the epigenetic regulator MIER1 to promote liver regeneration in a study with male mice.
Nature communications
Chen Y,Chen L,Wu X,Zhao Y,Wang Y,Jiang D,Liu X,Zhou T,Li S,Wei Y,Liu Y,Hu C,Zhou B,Qin J,Ying H,Ding Q
A-21311 was used in Flow Cytometry to identify an epigenetic mechanism by which the early phase lipid redistribution from adipose tissue to liver during regeneration impacts hepatocyte proliferation, and suggest a potential strategy to boost liver regeneration.
Sat Mar 18 00:00:00 EDT 2023
Quantitative trait loci on chromosomes 9 and 19 modulate AII amacrine cell number in the mouse retina.
Frontiers in neuroscience
Kulesh B,Bozadjian R,Parisi RJ,Leong SA,Kautzman AG,Reese BE,Keeley PW
A-21311 was used in Flow Cytometry to identify candidate causal genes and their sequence variants controlling the number of one type of retinal neuron, the AII amacrine cell.
Thu Oct 12 00:00:00 EDT 2023
Meis1 establishes the pre-hemogenic endothelial state prior to Runx1 expression.
Nature communications
Coulombe P,Cole G,Fentiman A,Parker JDK,Yung E,Bilenky M,Degefie L,Lac P,Ling MYM,Tam D,Humphries RK,Karsan A
A-21311 was used in Immunohistochemistry to identify the transcription factor Meis1 as an essential regulator of hemogenic cell specification in the embryo prior to Runx1 expression.
Thu Jul 27 00:00:00 EDT 2023
Fast and sensitive GCaMP calcium indicators for imaging neural populations.
Nature
Zhang Y,Rózsa M,Liang Y,Bushey D,Wei Z,Zheng J,Reep D,Broussard GJ,Tsang A,Tsegaye G,Narayan S,Obara CJ,Lim JX,Patel R,Zhang R,Ahrens MB,Turner GC,Wang SS,Korff WL,Schreiter ER,Svoboda K,Hasseman JP,Kolb I,Looger LL
A-21311 was used in Immunohistochemistry-immunofluorescence to show that jGCaMP8 sensors will allow tracking of large populations of neurons on timescales relevant to neural computation.
Wed Mar 01 00:00:00 EST 2023
Rgp1 contributes to craniofacial cartilage development and Rab8a-mediated collagen II secretion.
Frontiers in endocrinology
Ritter DJ,Choudhary D,Unlu G,Knapik EW
A-21311 was used in Immunohistochemistry-immunofluorescence to propose that an Rgp1-regulated Rab6a-Rab8a pathway directs secretion of ECM cargoes such as collagen II, a pathway that may also be utilized in other tissues where coordinated trafficking and secretion of collagens and other large cargoes is required for normal development and tissue function.
Tue Feb 28 00:00:00 EST 2023
Dax1 modulates ERα-dependent hypothalamic estrogen sensing in female mice.
Nature communications
Ramos-Pittol JM,Fernandes-Freitas I,Milona A,Manchishi SM,Rainbow K,Lam BYH,Tadross JA,Beucher A,Colledge WH,Cebola I,Murphy KG,Miguel-Aliaga I,Yeo GSH,Dhillo WS,Owen BM
A-21311 was used in Immunohistochemistry-immunofluorescence to provide mechanistic insight into how ERα may control the KISS1-neuron, and Kiss1 gene expression, to couple gonadotropin release to the developmental stage of the oocyte.
Mon May 29 00:00:00 EDT 2023
The arginine methyltransferase PRMT5 promotes mucosal defense in the intestine.
Life science alliance
Hernandez JE,Llorente C,Ma S,Miyamoto KT,Sinha S,Steele S,Xiao Z,Lai CJ,Zuniga EI,Ghosh P,Schnabl B,Huang WJM
A-21311 was used in Flow Cytometry to report that Prmt5 in the murine colon is up-regulated in response to Citrobacter rodentium infection.
Wed Nov 01 00:00:00 EDT 2023
Nutritional stress-induced regulation of microtubule organization and mRNP transport by HDAC1 controlled α-tubulin acetylation.
Communications biology
Wippich F,Hennrich ML,Ephrussi A
A-21311 was used in Immunohistochemistry to reveal that Drosophila HDAC1 senses and relays the nutritional status, which regulates germline development through modulation of cytoskeleton dynamics.
Tue Jul 25 00:00:00 EDT 2023
Distribution of microglia/immune cells in the brain of adult zebrafish in homeostatic and regenerative conditions: Focus on oxidative stress during brain repair.
The Journal of comparative neurology
Narra SS,Rondeau P,Fernezelian D,Gence L,Ghaddar B,Bourdon E,Lefebvre d'Hellencourt C,Rastegar S,Diotel N
A-21311 was used in Immunocytochemistry, Immunohistochemistry, Western Blot to provide a better characterization of microglia/immune cell distribution in the healthy zebrafish brain, highlighting some evolutionarily conserved features with mammals.
Wed Feb 01 00:00:00 EST 2023
Sources of Calcium at Connexin 36 Gap Junctions in the Retina.
eNeuro
Lee YH,Kothmann WW,Lin YP,Chuang AZ,Diamond JS,O'Brien J
A-21311 was used in Immunohistochemistry-immunofluorescence to investigate calcium dynamics at electrical synapses in the retina, revealing that many of these synapses respond to glutamate with transient increases in calcium fluorescence.
Tue Aug 01 00:00:00 EDT 2023
The NSL complex is required for piRNA production from telomeric clusters.
Life science alliance
Iyer SS,Sun Y,Seyfferth J,Manjunath V,Samata M,Alexiadis A,Kulkarni T,Gutierrez N,Georgiev P,Shvedunova M,Akhtar A
A-21311 was used in Immunohistochemistry-immunofluorescence to support a role for the NSL complex in promoting the transcription of piRNA precursors from telomeric piRNA clusters and in regulating Piwi levels in the Drosophila female germline.
Fri Sep 01 00:00:00 EDT 2023
Disentangling glial diversity in peripheral nerves at single-nuclei resolution.
Nature neuroscience
Yim AKY,Wang PL,Bermingham JR,Hackett A,Strickland A,Miller TM,Ly C,Mitra RD,Milbrandt J
A-21311 was used in Immunohistochemistry to reveal the diversity of SCs and other cell types in peripheral nerve and serve as a reference for future studies of nerve biology and disease.
Tue Feb 01 00:00:00 EST 2022
Tumor-specific interendothelial adhesion mediated by FLRT2 facilitates cancer aggressiveness.
The Journal of clinical investigation
Ando T,Tai-Nagara I,Sugiura Y,Kusumoto D,Okabayashi K,Kido Y,Sato K,Saya H,Navankasattusas S,Li DY,Suematsu M,Kitagawa Y,Seiradake E,Yamagishi S,Kubota Y
A-21311 was used in Immunohistochemistry to show that targeting this type of adhesion complex could be a safe and effective therapeutic option to suppress cancer progression.
Tue Mar 15 00:00:00 EDT 2022
P2RY8 variants in lupus patients uncover a role for the receptor in immunological tolerance.
The Journal of experimental medicine
He Y,Gallman AE,Xie C,Shen Q,Ma J,Wolfreys FD,Sandy M,Arsov T,Wu X,Qin Y,Zhang P,Jiang S,Stanley M,Wu P,Tan J,Ding H,Xue H,Chen W,Xu J,Criswell LA,Nititham J,Adamski M,Kitching AR,Cook MC,Cao L,Shen N,Cyster JG,Vinuesa CG
A-21311 was used in Immunohistochemistry-immunofluorescence to identify germline novel or rare P2RY8 missense variants in lupus kindreds or the related antiphospholipid syndrome, including a "de novo" variant in a child with severe nephritis to uncover a role of P2RY8 in immunological tolerance and lupus pathogenesis.
Mon Jan 03 00:00:00 EST 2022
Dopamine signaling in the dorsomedial striatum promotes compulsive behavior.
Current biology : CB
Seiler JL,Cosme CV,Sherathiya VN,Schaid MD,Bianco JM,Bridgemohan AS,Lerner TN
A-21311 was used in Immunohistochemistry to establish DMS dopamine signaling as a key controller of the development of compulsive reward seeking.
Mon Mar 14 00:00:00 EDT 2022
A Novel Homozygous Stop Mutation in IL23R Causes Mendelian Susceptibility to Mycobacterial Disease.
Journal of clinical immunology
Staels F,Lorenzetti F,De Keukeleere K,Willemsen M,Gerbaux M,Neumann J,Tousseyn T,Pasciuto E,De Munter P,Bossuyt X,Gijsbers R,Liston A,Humblet-Baron S,Schrijvers R
A-21311 was used in Immunocytochemistry-immunoflourescence to demonstrate that impaired IL-23 immunity caused by a homozygous R381X mutation in IL23R underlies MSMD, corroborating earlier findings with a homozygous p.C115Y IL23R mutation.
Tue Nov 01 00:00:00 EDT 2022
A meiotic switch in lysosome activity supports spermatocyte development in young flies but collapses with age.
iScience
Butsch TJ,Dubuisson O,Johnson AE,Bohnert KA
A-21311 was used in Immunohistochemistry to demonstrate that lysosome activation is entrained to meiotic progression in developing sperm, as in oocytes, and lysosomal dysfunction may instigate male reproductive aging.
Fri Jun 17 00:00:00 EDT 2022
Pharmacological inhibition of FOXO1 promotes lymphatic valve growth in a congenital lymphedema mouse model.
Frontiers in cell and developmental biology
Ogunsina O,Banerjee R,Knauer LA,Yang Y
A-21311 was used in Immunohistochemistry to indicate that pharmacological inhibition of FOXO1 can be explored as a viable strategy to resolve valve defects in congenital lymphedema.
Tue Feb 07 00:00:00 EST 2023
AAV-p40 Bioengineering Platform for Variant Selection Based on Transgene Expression.
Human gene therapy
Westhaus A,Cabanes-Creus M,Jonker T,Sallard E,Navarro RG,Zhu E,Baltazar Torres G,Lee S,Wilmott P,Gonzalez-Cordero A,Santilli G,Thrasher AJ,Alexander IE,Lisowski L
A-21311 was used in Immunohistochemistry (Frozen), Immunocytochemistry, Immunohistochemistry, Western Blot to discover that AAV-p40 is a ubiquitously active promoter that can be modified for cell-type-specific expression by incorporating binding sites for silencing transcription factors, allowing for cell-type-specific library selection.
Wed Jun 01 00:00:00 EDT 2022
Distinct features of brain perivascular fibroblasts and mural cells revealed by in vivo two-photon imaging.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Bonney SK,Sullivan LT,Cherry TJ,Daneman R,Shih AY
A-21311 was used in Immunohistochemistry-immunofluorescence to clarify that PVFs and mural cells are distinct cell types coexisting in a similar perivascular niche.
Wed Jun 01 00:00:00 EDT 2022
A noncanonical autophagy is involved in the transfer of Plasmodium-microvesicles to astrocytes.
Autophagy
Leleu I,Genete D,Desnoulez SS,Saidi N,Brodin P,Lafont F,Tomavo S,Pied S
A-21311 was used in Immunocytochemistry-immunofluorescence to shows that an unconventional LC3-mediated autophagy pathway independent of ULK1 is involved in the transfer and degradation of PbA-MVs inside the astrocytes.
Fri Jul 01 00:00:00 EDT 2022
Overexpression of mir-135b and mir-210 in mesenchymal stromal cells for the enrichment of extracellular vesicles with angiogenic factors.
PloS one
Vieira JMF,Zamproni LN,Wendt CHC,Rocha de Miranda K,Lindoso RS,Won Han S
A-21311 was used in Immunocytochemistry-immunoflourescence to show that extracellular vesicle cargo can be modified by lentiviral vectors to enrich specific miRNAs to achieve a specific angiogenic potential.
Thu Aug 18 00:00:00 EDT 2022
Evidence for oligodendrocyte progenitor cell heterogeneity in the adult mouse brain.
Scientific reports
Beiter RM,Rivet-Noor C,Merchak AR,Bai R,Johanson DM,Slogar E,Sol-Church K,Overall CC,Gaultier A
A-21311 was used in Immunohistochemistry-immunofluorescence to investigate the exact mechanisms through which Oligodendrocyte progenitor cells might influence brain function.
Thu Jul 28 00:00:00 EDT 2022
Regulation of Drosophila oviduct muscle contractility by octopamine.
iScience
Deshpande SA,Rohrbach EW,Asuncion JD,Harrigan J,Eamani A,Schlingmann EH,Suto DJ,Lee PT,Schweizer FE,Bellen HJ,Krantz DE
A-21311 was used in Immunohistochemistry to investigate if aminergic pathways in the oviposition circuit may be comparable to some of the mechanisms that regulate visceral muscle contractility in mammals.
Fri Aug 19 00:00:00 EDT 2022
Pyramidal tract neurons drive amplification of excitatory inputs to striatum through cholinergic interneurons.
Science advances
Morgenstern NA,Isidro AF,Israely I,Costa RM
A-21311 was used in Immunohistochemistry to report a novel circuit mechanism by which PT activity amplifies excitatory inputs to the striatum, with potential implications for behavior, plasticity, and learning.
Fri Feb 11 00:00:00 EST 2022
Morpho-functional analysis of the early changes induced in retinal ganglion cells by the onset of diabetic retinopathy: The effects of a neuroprotective strategy.
Pharmacological research
Amato R,Catalani E,Dal Monte M,Cammalleri M,Cervia D,Casini G
A-21311 was used in Immunohistochemistry-immunofluorescence to highlight the importance of neuronal protection in the early phases of diabetic retinopathy, when cell loss has not yet started and RGC morphology can be preserved or adjusted to maintain RGC physiology.
Tue Nov 01 00:00:00 EDT 2022
Novel dominant and recessive variants in human ROBO1 cause distinct neurodevelopmental defects through different mechanisms.
Human molecular genetics
Huang Y,Ma M,Mao X,Pehlivan D,Kanca O,Un-Candan F,Shu L,Akay G,Mitani T,Lu S,Candan S,Wang H,Xiao B,Lupski JR,Bellen HJ
A-21311 was used in Immunocytochemistry-immunofluorescence to report two novel ROBO1 variants associated with very distinct phenotypes.
Tue Aug 23 00:00:00 EDT 2022
Cellular Sources and Neuroprotective Roles of Interleukin-10 in the Facial Motor Nucleus after Axotomy.
Cells
Runge EM,Setter DO,Iyer AK,Regele EJ,Kennedy FM,Sanders VM,Jones KJ
A-21311 was used in Immunohistochemistry to suggest that coordinated neuronal and astrocytic IL-10 production is necessary for FMN survival and has roles in neuronal homeostasis, as well as neuroprotective trophism after axotomy.
Sun Oct 09 00:00:00 EDT 2022
A clearing-free protocol for imaging intact whole adipose tissue innervation in mice.
STAR protocols
Willows JW,Blaszkiewicz M,Townsend KL
A-21311 was used in Immunohistochemistry to provide a clearing-free protocol for processing intact, whole mount subcutaneous white adipose tissue (scWAT) for immunofluorescence as an alternative to current clearing-based approaches.
Fri Mar 18 00:00:00 EDT 2022
Plasmodium parasitophorous vacuole membrane-resident protein UIS4 manipulates host cell actin to avoid parasite elimination.
iScience
M'Bana V,Lahree A,Marques S,Slavic K,Mota MM
A-21311 was used in Immunocytochemistry-immunoflourescence to reveal that UIS4 has a critical role in the evasion of host defensive mechanisms, enabling hence EEF survival and development.
Fri May 20 00:00:00 EDT 2022
N-myc downstream regulated gene 1 (ndrg1) functions as a molecular switch for cellular adaptation to hypoxia.
eLife
Park JS,Gabel AM,Kassir P,Kang L,Chowdhary PK,Osei-Ntansah A,Tran ND,Viswanathan S,Canales B,Ding P,Lee YS,Brewster R
A-21311 was used in Immunohistochemistry to support a model whereby Ndrg1a is essential for hypoxia adaptation and functions downstream of lactate signaling to induce NKA degradation, a process known to conserve cellular energy.
Mon Oct 10 00:00:00 EDT 2022
A High-Efficiency AAV for Endothelial Cell Transduction Throughout the Central Nervous System.
Nature cardiovascular research
Krolak T,Chan KY,Kaplan L,Huang Q,Wu J,Zheng Q,Kozareva V,Beddow T,Tobey IG,Pacouret S,Chen AT,Chan YA,Ryvkin D,Gu C,Deverman BE
A-21311 was used in Immunohistochemistry-immunofluorescence to demonstrate AAV-BI30's capacity to achieve efficient and endothelial-specific Cre-mediated gene manipulation in the central nervous system.
Fri Apr 01 00:00:00 EDT 2022
Enkephalin release from VIP interneurons in the hippocampal CA2/3a region mediates heterosynaptic plasticity and social memory.
Molecular psychiatry
Leroy F,de Solis CA,Boyle LM,Bock T,Lofaro OM,Buss EW,Asok A,Kandel ER,Siegelbaum SA
A-21311 was used in Immunohistochemistry to enhance our appreciation of how GABAergic neurons can regulate synaptic plasticity and mnemonic behavior by demonstrating that such actions can be mediated by release of a specific neuropeptide, rather than through classic fast inhibitory transmission.
Wed Jun 01 00:00:00 EDT 2022
Spatiotemporal dynamics of noradrenaline during learned behaviour.
Nature
Breton-Provencher V,Drummond GT,Feng J,Li Y,Sur M
A-21311 was used in Immunohistochemistry to show that LC-NA activity displays distinct spatiotemporal dynamics to enable two functions during learned behaviour: facilitating task execution and encoding reinforcement to improve performance accuracy.
Wed Jun 01 00:00:00 EDT 2022
CXCL10 chemokine regulates heterogeneity of the CD8+ T cell response and viral set point during chronic infection.
Immunity
Ozga AJ,Chow MT,Lopes ME,Servis RL,Di Pilato M,Dehio P,Lian J,Mempel TR,Luster AD
A-21311 was used in Immunocytochemistry, Immunohistochemistry, Western Blot, Flow Cytometry to find that the chemokine receptor CXCR3 is highly expressed on viral-specific stem-like CD8+ T cells and that one of its ligands, CXCL10, regulates the persistence and heterogeneity of responding CD8+ T cells in spleens of mice chronically infected with lymphocytic choriomeningitis virus.
Tue Jan 11 00:00:00 EST 2022
Adaptive Mossy Cell Circuit Plasticity after Status Epilepticus.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Butler CR,Westbrook GL,Schnell E
A-21311 was used in Immunohistochemistry to suggest that residual mossy cell outputs can reorganize in a homeostatic manner, which may provide clues for therapeutic targeting of this microcircuit.
Wed Apr 06 00:00:00 EDT 2022
Stroke-Induced Neurological Dysfunction in Aged Mice Is Attenuated by Preconditioning with Young Sca-1+ Stem Cells.
Stem cells (Dayton, Ohio)
Wlodarek L,Alibhai FJ,Wu J,Li SH,Li RK
A-21311 was used in Immunohistochemistry-immunofluorescence to provide a proof-of-principle demonstrating that young BM Sca-1+ cells play a pivotal role in reversing stroke-induced cognitive impairments and protect the aged brain against secondary injury by attenuating the host cell response to injury.
Wed Jun 22 00:00:00 EDT 2022
Essential Roles of Exocyst Complex Component 3-like 2 on Cardiovascular Development in Mice.
Life (Basel, Switzerland)
Watanabe C,Shibuya H,Ichiyama Y,Okamura E,Tsukiyama-Fujii S,Tsukiyama T,Matsumoto S,Matsushita J,Azami T,Kubota Y,Ohji M,Sugiyama F,Takahashi S,Mizuno S,Tamura M,Mizutani KI,Ema M
A-21311 was used in Immunohistochemistry to reveal that Exoc3l2 is essential for cardiovascular and brain development in mice.
Fri Oct 28 00:00:00 EDT 2022
Macrophage depletion blocks congenital SARM1-dependent neuropathy.
The Journal of clinical investigation
Dingwall CB,Strickland A,Yum SW,Yim AK,Zhu J,Wang PL,Yamada Y,Schmidt RE,Sasaki Y,Bloom AJ,DiAntonio A,Milbrandt J
A-21311 was used in Immunohistochemistry to demonstrate that SARM1 induced inflammatory neuropathy and highlight the potential of immune therapy as a treatment for this rare syndrome and other neurodegenerative conditions associated with NMNAT2 loss and SARM1 activation.
Thu Dec 01 00:00:00 EST 2022
Serine palmitoyltransferase assembles at ER-mitochondria contact sites.
Life science alliance
Aaltonen MJ,Alecu I,König T,Bennett SA,Shoubridge EA
A-21311 was used in Immunocytochemistry-immunofluorescence to reveal the in trans assembly of an enzymatic complex at an organellar membrane contact site, providing novel insight into the localization of sphingolipid synthesis and the composition and function of ER-mitochondria contact sites.
Tue Feb 01 00:00:00 EST 2022
Sensory neuron-derived TAFA4 promotes macrophage tissue repair functions.
Nature
Hoeffel G,Debroas G,Roger A,Rossignol R,Gouilly J,Laprie C,Chasson L,Barbon PV,Balsamo A,Reynders A,Moqrich A,Ugolini S
A-21311 was used in Flow Cytometry to demonstrate a major role for sensory neurons in promoting the tissue-repair function of macrophages.
Tue Jun 01 00:00:00 EDT 2021
Histone lysine methyltransferase Pr-set7/SETD8 promotes neural stem cell reactivation.
EMBO reports
Huang J,Gujar MR,Deng Q,Y Chia S,Li S,Tan P,Sung WK,Wang H
A-21311 was used in Immunohistochemistry to contribute to the understanding of mammalian KMT5A/PR-SET7/SETD8 during brain development.
Wed Apr 07 00:00:00 EDT 2021
Deubiquitinating Enzyme USP21 Inhibits HIV-1 Replication by Downregulating Tat Expression.
Journal of virology
Gao W,Li G,Zhao S,Wang H,Huan C,Zheng B,Jiang C,Zhang W
A-21311 was used in Western Blot to report a novel role of the deubiquitinase, USP21, in HIV-1 infection. USP21 represents a potentially useful target for the development of novel anti-HIV drugs.
Thu Jun 10 00:00:00 EDT 2021
Developing Fast, Red-Light Optogenetic Stimulation of Spiral Ganglion Neurons for Future Optical Cochlear Implants.
Frontiers in molecular neuroscience
Huet AT,Dombrowski T,Rankovic V,Thirumalai A,Moser T
A-21311 was used in Immunohistochemistry-immunofluorescence to employ a fast variant of the red-light activated channelrhodopsin Chrimson (f-Chrimson) and different AAV variants to implement optogenetic SGN stimulation in Mongolian gerbils.
Sat Nov 11 00:00:00 EST 2023
Environmental Enrichment Induces Meningeal Niche Remodeling through TrkB-Mediated Signaling.
International journal of molecular sciences
Zorzin S,Corsi A,Ciarpella F,Bottani E,Dolci S,Malpeli G,Pino A,Amenta A,Fumagalli GF,Chiamulera C,Bifari F,Decimo I
A-21311 was used in Immunohistochemistry to analyse the effects of environmental enrichment exposure on neural precursors distribution in mouse brain meninges.
Fri Oct 01 00:00:00 EDT 2021
Detecting single cell interferon-beta production using a fluorescent reporter telomerase-immortalized human fibroblast cell line.
STAR protocols
Hare DN,Subapanditha MK,Mossman KL
A-21311 was used in Flow Cytometry to suggest that cells respond to infection by upregulating the antiviral cytokine interferon-beta (IFN-ß) in a fraction of infected cells.
Fri Jun 18 00:00:00 EDT 2021
Cystin genetic variants cause autosomal recessive polycystic kidney disease associated with altered Myc expression.
Scientific reports
Yang C,Harafuji N,O'Connor AK,Kesterson RA,Watts JA,Majmundar AJ,Braun DA,Lek M,Laricchia KM,Fathy HM,Mane S,Shril S,Hildebrandt F,Guay-Woodford LM
A-21311 was used in Immunohistochemistry-immunofluorescence to suggest that mutations in Cys1/CYS1 cause an ARPKD phenotype in mouse and human, respectively, and that the renal cystic phenotype in the mouse is driven by overexpression of the Myc proto-oncogene.
Tue Sep 14 00:00:00 EDT 2021
All-Optical Electrophysiology in hiPSC-Derived Neurons With Synthetic Voltage Sensors.
Frontiers in cellular neuroscience
Puppo F,Sadegh S,Trujillo CA,Thunemann M,Campbell EP,Vandenberghe M,Shan X,Akkouh IA,Miller EW,Bloodgood BL,Silva GA,Dale AM,Einevoll GT,Djurovic S,Andreassen OA,Muotri AR,Devor A
A-21311 was used in Immunohistochemistry to demonstrate the functionality of this method by measuring spontaneous and evoked activity in three independent hiPSC-derived neuronal cell lines with distinct genetic backgrounds.
Tue May 02 00:00:00 EDT 2023
Macrophage mediated recognition and clearance of Borrelia burgdorferi elicits MyD88-dependent and -independent phagosomal signals that contribute to phagocytosis and inflammation.
BMC immunology
Benjamin SJ,Hawley KL,Vera-Licona P,La Vake CJ,Cervantes JL,Ruan Y,Radolf JD,Salazar JC
A-21311 was used in Immunocytochemistry to show that MyD88 signaling enhances, but is not required, for bacterial uptake or phagosomal maturation and provide mechanistic insights into how MyD88-mediated phagosomal signaling enhances Bb uptake and clearance.
Mon May 17 00:00:00 EDT 2021
Whole-brain mapping of monosynaptic inputs to midbrain cholinergic neurons.
Scientific reports
Huerta-Ocampo I,Dautan D,Gut NK,Khan B,Mena-Segovia J
A-21311 was used in Immunohistochemistry to characterize the whole-brain input connectome to cholinergic neurons across distinct functional domains (i.e. PPN vs LDT) using conditional transsynaptic retrograde labeling in ChAT::Cre male and female rats.
Tue Apr 27 00:00:00 EDT 2021
Hepatocyte membrane potential regulates serum insulin and insulin sensitivity by altering hepatic GABA release.
Cell reports
Geisler CE,Ghimire S,Hepler C,Miller KE,Bruggink SM,Kentch KP,Higgins MR,Banek CT,Yoshino J,Klein S,Renquist BJ
A-21311 was used in Immunohistochemistry to identify GABA as a neuro-hepatokine that is dysregulated in obesity and whose release can be manipulated to mute or exacerbate the glucoregulatory dysfunction common to obesity.
Tue Jun 29 00:00:00 EDT 2021
Generation of Mesenchymal Cell Lines Derived from Aged Donors.
International journal of molecular sciences
Piñeiro-Ramil M,Sanjurjo-Rodríguez C,Rodríguez-Fernández S,Castro-Viñuelas R,Hermida-Gómez T,Blanco-García FJ,Fuentes-Boquete I,Díaz-Prado S
A-21311 was used in Immunocytochemistry to show primary MSCs from elderly patients can be immortalized by transduction of simian virus 40 large T antigen and human telomerase reverse transcriptase.
Fri Oct 01 00:00:00 EDT 2021
A visual pathway for skylight polarization processing in Drosophila.
eLife
Hardcastle BJ,Omoto JJ,Kandimalla P,Nguyen BM,Keleş MF,Boyd NK,Hartenstein V,Frye MA
A-21311 was used in Immunohistochemistry to identify computational motifs of the transformation, enabling mechanistic comparisons of multisensory integration and central processing for navigation in the brains of insects.
Tue Mar 23 00:00:00 EDT 2021
Pocket MUSE: an affordable, versatile and high-performance fluorescence microscope using a smartphone.
Communications biology
Liu Y,Rollins AM,Levenson RM,Fereidouni F,Jenkins MW
A-21311 was used in Immunohistochemistry to demonstrates the first practical implementation of Microscopy with Ultraviolet Surface Excitation (MUSE) in a compact smartphone microscope called Pocket MUSE.
Fri Mar 12 00:00:00 EST 2021
Dermal White Adipose Tissue (dWAT) Is Regulated by Foxn1 and Hif-1α during the Early Phase of Skin Wound Healing.
International journal of molecular sciences
Gawronska-Kozak B,Walendzik K,Machcinska S,Padzik A,Kopcewicz M,Wiśniewska J
A-21311 was used in Immunocytochemistry, Immunohistochemistry, Western Blot, Flow Cytometry to document that Foxn1 and Hif-1α cooperatively regulate dWAT during the proliferative phase of skin wound healing through the Igf2 signaling pathway, and reduce the macrophages content in the wound site.
Mon Dec 27 00:00:00 EST 2021
Epigenomic diversity of cortical projection neurons in the mouse brain.
Nature
Zhang Z,Zhou J,Tan P,Pang Y,Rivkin AC,Kirchgessner MA,Williams E,Lee CT,Liu H,Franklin AD,Miyazaki PA,Bartlett A,Aldridge AI,Vu M,Boggeman L,Fitzpatrick C,Nery JR,Castanon RG,Rashid M,Jacobs MW,Ito-Cole T,O'Connor C,Pinto-Duartec A,Dominguez B,Smith JB,Niu SY,Lee KF,Jin X,Mukamel EA,Behrens MM,Ecker JR,Callaway EM
A-21311 was used in Miscellaneous, Immunocytochemistry, Immunohistochemistry, Western Blot to highlight the power of single-cell epigenomic approaches to connect the molecular properties of neurons with their anatomical and projection properties.
Fri Oct 01 00:00:00 EDT 2021
Super-resolution microscopy reveals that Na+/K+-ATPase signaling protects against glucose-induced apoptosis by deactivating Bad.
Cell death & disease
Bernhem K,Fontana JM,Svensson D,Zhang L,Nilsson LM,Scott L,Blom H,Brismar H,Aperia A
A-21311 was used in Immunocytochemistry to study the early steps in the apoptotic process using super-resolution microscopy.
Tue Jul 27 00:00:00 EDT 2021
Commensal segmented filamentous bacteria-derived retinoic acid primes host defense to intestinal infection.
Cell host & microbe
Woo V,Eshleman EM,Hashimoto-Hill S,Whitt J,Wu SE,Engleman L,Rice T,Karns R,Qualls JE,Haslam DB,Vallance BA,Alenghat T
A-21311 was used in Immunocytochemistry, Immunohistochemistry, Western Blot, Flow Cytometry to reveal retinoic acid (RA) as an unexpected microbiota-derived metabolite that primes innate defense and suggests that pre- and probiotic approaches to elevate RA could prevent or combat infections.
Wed Dec 08 00:00:00 EST 2021
Abcc1 and Ggt5 support lymphocyte guidance through export and catabolism of S-geranylgeranyl-l-glutathione.
Science immunology
Gallman AE,Wolfreys FD,Nguyen DN,Sandy M,Xu Y,An J,Li Z,Marson A,Lu E,Cyster JG
A-21311 was used in Immunohistochemistry to show that gamma-glutamyltransferase-5 (Ggt5) expression in stromal cells was required for S-geranylgeranyl-l-glutathione catabolism and confinement of P2RY8-expressing cells to germinal centers.
Fri Jun 04 00:00:00 EDT 2021
Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche.
Nature
Roulis M,Kaklamanos A,Schernthanner M,Bielecki P,Zhao J,Kaffe E,Frommelt LS,Qu R,Knapp MS,Henriques A,Chalkidi N,Koliaraki V,Jiao J,Brewer JR,Bacher M,Blackburn HN,Zhao X,Breyer RM,Aidinis V,Jain D,Su B,Herschman HR,Kluger Y,Kollias G,Flavell RA
A-21311 was used in Immunohistochemistry (Frozen) to provide in vivo evidence that the mesenchymal niche controls tumour initiation in trans.
Wed Apr 01 00:00:00 EDT 2020
Microbiota modulate sympathetic neurons via a gut-brain circuit.
Nature
Muller PA,Schneeberger M,Matheis F,Wang P,Kerner Z,Ilanges A,Pellegrino K,Del Mármol J,Castro TBR,Furuichi M,Perkins M,Han W,Rao A,Pickard AJ,Cross JR,Honda K,de Araujo I,Mucida D
A-21311 was used in Immunohistochemistry-immunofluorescence to find that the gut microbiome modulates gut-extrinsic sympathetic neurons: microbiota depletion leads to increased expression of the neuronal transcription factor cFos, and colonization of germ-free mice with bacteria that produce short-chain fatty acids suppresses cFos expression in the gut sympathetic ganglia.
Wed Jul 01 00:00:00 EDT 2020
Gut-educated IgA plasma cells defend the meningeal venous sinuses.
Nature
Fitzpatrick Z,Frazer G,Ferro A,Clare S,Bouladoux N,Ferdinand J,Tuong ZK,Negro-Demontel ML,Kumar N,Suchanek O,Tajsic T,Harcourt K,Scott K,Bashford-Rogers R,Helmy A,Reich DS,Belkaid Y,Lawley TD,McGavern DB,Clatworthy MR
A-21311 was used in Immunohistochemistry to show that, during homeostasis, the mouse and human meninges contain IgA-secreting plasma cells.
Sun Nov 01 00:00:00 EDT 2020
An Amygdala Circuit Mediates Experience-Dependent Momentary Arrests during Exploration.
Cell
Botta P,Fushiki A,Vicente AM,Hammond LA,Mosberger AC,Gerfen CR,Peterka D,Costa RM
A-21311 was used in Immunohistochemistry to uncover an amygdala circuit that mediates momentary arrests in familiar places but not avoidance or anxiety/fear-like behaviors.
Thu Oct 29 00:00:00 EDT 2020
Multifaceted Effects of Antigen Valency on B Cell Response Composition and Differentiation In Vivo.
Immunity
Kato Y,Abbott RK,Freeman BL,Haupt S,Groschel B,Silva M,Menis S,Irvine DJ,Schief WR,Crotty S
A-21311 was used in Immunohistochemistry to discover that antigen valency has multifaceted effects on B cell responses and can dictate affinity thresholds and competitive landscapes for B cells in vivo.
Tue Sep 15 00:00:00 EDT 2020
Extensive Remodeling of the Immune Microenvironment in B Cell Acute Lymphoblastic Leukemia.
Cancer cell
Witkowski MT,Dolgalev I,Evensen NA,Ma C,Chambers T,Roberts KG,Sreeram S,Dai Y,Tikhonova AN,Lasry A,Qu C,Pei D,Cheng C,Robbins GA,Pierro J,Selvaraj S,Mezzano V,Daves M,Lupo PJ,Scheurer ME,Loomis CA,Mullighan CG,Chen W,Rabin KR,Tsirigos A,Carroll WL,Aifantis I
A-21311 was used in Immunohistochemistry to identify extrinsic regulators of B-ALL survival supporting new immune-based therapeutic approaches for high-risk B-ALL treatment.
Mon Jun 08 00:00:00 EDT 2020
Smooth Muscle Cell Reprogramming in Aortic Aneurysms.
Cell stem cell
Chen PY,Qin L,Li G,Malagon-Lopez J,Wang Z,Bergaya S,Gujja S,Caulk AW,Murtada SI,Zhang X,Zhuang ZW,Rao DA,Wang G,Tobiasova Z,Jiang B,Montgomery RR,Sun L,Sun H,Fisher EA,Gulcher JR,Fernandez-Hernando C,Humphrey JD,Tellides G,Chittenden TW,Simons M
A-21311 was used in Immunohistochemistry to investigate the interactions between these different factors in aortic aneurysm development and identify a key role for smooth muscle cell (SMC) reprogramming into a mesenchymal stem cell (MSC)-like state.
Thu Apr 02 00:00:00 EDT 2020
Chronic mTOR activation induces a degradative smooth muscle cell phenotype.
The Journal of clinical investigation
Li G,Wang M,Caulk AW,Cilfone NA,Gujja S,Qin L,Chen PY,Chen Z,Yousef S,Jiao Y,He C,Jiang B,Korneva A,Bersi MR,Wang G,Liu X,Mehta S,Geirsson A,Gulcher JR,Chittenden TW,Simons M,Humphrey JD,Tellides G
A-21311 was used in Immunohistochemistry-immunofluorescence to investigate the effects of smooth muscle cell proliferation in the aortic media by conditional disruption of Tsc1, which hyperactivates mTOR complex 1.
Mon Mar 02 00:00:00 EST 2020
Extraction of Distinct Neuronal Cell Types from within a Genetically Continuous Population.
Neuron
Kim EJ,Zhang Z,Huang L,Ito-Cole T,Jacobs MW,Juavinett AL,Senturk G,Hu M,Ku M,Ecker JR,Callaway EM
A-21311 was used in Immunohistochemistry to demonstrate that gene-expression analysis in isolation is insufficient to identify neuron types and have important implications for understanding the functional role of cortical feedback circuits.
Wed Jul 22 00:00:00 EDT 2020
Cell-intrinsic adrenergic signaling controls the adaptive NK cell response to viral infection.
The Journal of experimental medicine
Diaz-Salazar C,Bou-Puerto R,Mujal AM,Lau CM,von Hoesslin M,Zehn D,Sun JC
A-21311 was used in Immunohistochemistry to propose a novel role for the adrenergic nervous system in regulating circulating lymphocyte responses to viral infection.
Mon Apr 06 00:00:00 EDT 2020
Targeted De Novo Centromere Formation in Drosophila Reveals Plasticity and Maintenance Potential of CENP-A Chromatin.
Developmental cell
Palladino J,Chavan A,Sposato A,Mason TD,Mellone BG
A-21311 was used in Immunohistochemistry to underpin the ability of CENP-A chromatin to establish and sustain mitotic centromere function in Drosophila.
Mon Feb 10 00:00:00 EST 2020
TRIM21-mediated proteasomal degradation of SAMHD1 regulates its antiviral activity.
EMBO reports
Li Z,Huan C,Wang H,Liu Y,Liu X,Su X,Yu J,Zhao Z,Yu XF,Zheng B,Zhang W
A-21311 was used in Western Blotting to show the antiviral activity of SAMHD1 is regulated by proteasomal degradation activated by E3 ubiquitin ligase TRIM21.
Tue Jan 07 00:00:00 EST 2020
Fgfbp1 promotes blood-brain barrier development by regulating collagen IV deposition and maintaining Wnt/β-catenin signaling.
Development (Cambridge, England)
Cottarelli A,Corada M,Beznoussenko GV,Mironov AA,Globisch MA,Biswas S,Huang H,Dimberg A,Magnusson PU,Agalliu D,Lampugnani MG,Dejana E
A-21311 was used in Immunocytochemistry to conclude that Fgfbp1 is a crucial extracellular matrix protein during BBB maturation that regulates cell-cell interactions and Wnt/β-catenin activity.
Mon Aug 24 00:00:00 EDT 2020
Drosophila Voltage-Gated Sodium Channels Are Only Expressed in Active Neurons and Are Localized to Distal Axonal Initial Segment-like Domains.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ravenscroft TA,Janssens J,Lee PT,Tepe B,Marcogliese PC,Makhzami S,Holmes TC,Aerts S,Bellen HJ
A-21311 was used in Immunohistochemistry-immunofluorescence to determine the endogenous gene expression and subcellular localization of the sole NaV channel in both male and female Drosophila, para Despite being the only NaV channel in the fly, we show that only 23 1% of neurons in the embryonic and larval CNS express para, while in the adult CNS para is broadly expressed.
Wed Oct 14 00:00:00 EDT 2020
Neuronal Glutamatergic Synaptic Clefts Alkalinize Rather Than Acidify during Neurotransmission.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Stawarski M,Hernandez RX,Feghhi T,Borycz JA,Lu Z,Agarwal AB,Reihl KD,Tavora R,Lau AWC,Meinertzhagen IA,Renden R,Macleod GT
A-21311 was used in Immunohistochemistry to suggest that cleft alkalinization during neurotransmission, rather than acidification, is a generalizable phenomenon across conventional neuronal synapses.
Wed Feb 19 00:00:00 EST 2020
Tbx20 Induction Promotes Zebrafish Heart Regeneration by Inducing Cardiomyocyte Dedifferentiation and Endocardial Expansion.
Frontiers in cell and developmental biology
Fang Y,Lai KS,She P,Sun J,Tao W,Zhong TP
A-21311 was used in Immunohistochemistry-immunofluorescence to demonstrate that Tbx20 induction promotes adult heart regeneration by inducing cardiomyocyte dedifferentiation as well as non-cell-autonomously enhancing endocardial cell regeneration.
Mon Sep 28 00:00:00 EDT 2020
SynGAP splice variants display heterogeneous spatio-temporal expression and subcellular distribution in the developing mammalian brain.
Journal of neurochemistry
Gou G,Roca-Fernandez A,Kilinc M,Serrano E,Reig-Viader R,Araki Y,Huganir RL,de Quintana-Schmidt C,Rumbaugh G,Bayés À
A-21311 was used in Immunocytochemistry-Immunofluorescence to hypothesize that different SynGAP isoforms will mediate different sets of functions and that deciphering their spatio-temporal expression and subcellular localization will accelerate understanding their multiple functions.
Tue Sep 01 00:00:00 EDT 2020
Immortalizing Mesenchymal Stromal Cells from Aged Donors While Keeping Their Essential Features.
Stem cells international
Piñeiro-Ramil M,Castro-Viñuelas R,Sanjurjo-Rodríguez C,Rodríguez-Fernández S,Hermida-Gómez T,Blanco-García FJ,Fuentes-Boquete I,Díaz-Prado S
A-21311 was used in Immunocytochemistry-immunoflourescence to develop a transduction method suitable for the immortalization of MSCs from aged donors.
Mon Sep 28 00:00:00 EDT 2020
Peripheral interleukin-1β inhibits arcuate kiss1 cells and LH pulses in female mice.
The Journal of endocrinology
Makowski KN,Kreisman MJ,McCosh RB,Raad AA,Breen KM
A-21311 was used in Immunohistochemistry to support a neural mechanism whereby peripheral immune/inflammatory stress impairs reproductive neuroendocrine function via inhibition of kisspeptin cell activation and reduced pulsatile luteinizing hormone secretion.
Sat Aug 01 00:00:00 EDT 2020
LIM and SH3 protein 1 localizes to the leading edge of protruding lamellipodia and regulates axon development.
Molecular biology of the cell
Pollitt SL,Myers KR,Yoo J,Zheng JQ
A-21311 was used in Immunocytochemistry-immunoflourescence to determine the role of LIM and SH3 protein 1 (LASP1) in axon development through localisation along the leading edge of lamellipodia.
Sun Nov 15 00:00:00 EST 2020
CD19-targeted CAR regulatory T cells suppress B cell pathology without GvHD.
JCI insight
Imura Y,Ando M,Kondo T,Ito M,Yoshimura A
A-21311 was used in Flow cytometry/Cell sorting to suggest that CD19-CAR regulatory T cells can treat autoantibody-mediated autoimmune diseases by suppressing B cell pathology.
Thu Jul 23 00:00:00 EDT 2020
Feature-rich covalent stains for super-resolution and cleared tissue fluorescence microscopy.
Science advances
Mao C,Lee MY,Jhan JR,Halpern AR,Woodworth MA,Glaser AK,Chozinski TJ,Shin L,Pippin JW,Shankland SJ,Liu JTC,Vaughan JC
A-21311 was used in Immunohistochemistry, Immunocytochemistry to report the use of conventional, commercially available fluorescent dyes for rapid and intense covalent labeling of proteins and carbohydrates in super-resolution (expansion) microscopy and cleared tissue microscopy.
Fri May 01 00:00:00 EDT 2020
Feature-rich covalent stains for super-resolution and cleared tissue fluorescence microscopy.
Science advances
Mao C,Lee MY,Jhan JR,Halpern AR,Woodworth MA,Glaser AK,Chozinski TJ,Shin L,Pippin JW,Shankland SJ,Liu JTC,Vaughan JC
A-21311 was used in Immunohistochemistry, Immunocytochemistry to report the use of conventional, commercially available fluorescent dyes for rapid and intense covalent labeling of proteins and carbohydrates in super-resolution (expansion) microscopy and cleared tissue microscopy.
Fri May 01 00:00:00 EDT 2020
Distribution of Midbrain Cholinergic Axons in the Thalamus.
eNeuro
Huerta-Ocampo I,Hacioglu-Bay H,Dautan D,Mena-Segovia J
A-21311 was used in Immunohistochemistry to show midbrain cholinergic neurons innervate almost the entire thalamus whilst maintaining functional segregation.
Fri Jun 18 00:00:00 EDT 2021
Cholinergic midbrain afferents modulate striatal circuits and shape encoding of action strategies.
Nature communications
Dautan D,Huerta-Ocampo I,Gut NK,Valencia M,Kondabolu K,Kim Y,Gerdjikov TV,Mena-Segovia J
A-21311 was used in Immunohistochemistry-immunofluorescence to show cholinergic neurons of the midbrain modulate cholinergic interneurons.
Wed Apr 08 00:00:00 EDT 2020
Transverse sinus injections drive robust whole-brain expression of transgenes.
eLife
Hamodi AS,Martinez Sabino A,Fitzgerald ND,Moschou D,Crair MC
A-21311 was used in Immunohistochemistry to develop a novel method for efficient gene delivery across the central nervous system in neonatal mice and rats starting as early as P1 and persisting into adulthood.
Mon May 18 00:00:00 EDT 2020
Dissemination of RasV12-transformed cells requires the mechanosensitive channel Piezo.
Nature communications
Lee J,Cabrera AJH,Nguyen CMT,Kwon YV
A-21311 was used in Immunohistochemistry-immunofluorescence to establish an in vivo model for studying how transformed cells migrate out from a complex tissue and provide unique insights into the roles of Piezo in invasive cell behavior.
Thu Jul 16 00:00:00 EDT 2020
Surveillance of cohesin-supported chromosome structure controls meiotic progression.
Nature communications
Castellano-Pozo M,Pacheco S,Sioutas G,Jaso-Tamame AL,Dore MH,Karimi MM,Martinez-Perez E
A-21311 was used in Immunocytochemistry-immunoflourescence to uncover an unexpected plasticity of the meiotic programme and show how chromosome signalling orchestrates nuclear organisation and meiotic progression.
Fri Aug 28 00:00:00 EDT 2020
Rapid Crypt Cell Remodeling Regenerates the Intestinal Stem Cell Niche after Notch Inhibition.
Stem cell reports
Bohin N,Keeley TM,Carulli AJ,Walker EM,Carlson EA,Gao J,Aifantis I,Siebel CW,Rajala MW,Myers MG,Jones JC,Brindley CD,Dempsey PJ,Samuelson LC
A-21311 was used in Immunohistochemistry to define the cellular remodeling process resulting from ISC niche interruption by transient Notch pathway inhibition in adult mice.
Tue Jul 14 00:00:00 EDT 2020
Parvalbumin interneurons provide spillover to newborn and mature dentate granule cells.
eLife
Vaden RJ,Gonzalez JC,Tsai MC,Niver AJ,Fusilier AR,Griffith CM,Kramer RH,Wadiche JI,Overstreet-Wadiche L
A-21311 was used in Immunohistochemistry to suggest that PVs mediate slow spillover signaling in addition to conventional fast synaptic signaling, and that spillover transmission mediates activity-dependent regulation of early events in adult neurogenesis.
Tue Jun 30 00:00:00 EDT 2020
Generation of Novel Plasmodium falciparum NF135 and NF54 Lines Expressing Fluorescent Reporter Proteins Under the Control of Strong and Constitutive Promoters.
Frontiers in cellular and infection microbiology
Miyazaki S,Yang ASP,Geurten FJA,Marin-Mogollon C,Miyazaki Y,Imai T,Kolli SK,Ramesar J,Chevalley-Maurel S,Salman AM,van Gemert GA,van Waardenburg YM,Franke-Fayard B,Hill AVS,Sauerwein RW,Janse CJ,Khan SM
A-21311 was used in Immunocytochemistry to describe the generation of novel reporter lines, using CRISPR/Cas9 gene modification, both in the standard Pf NF54 background and in a recently described Cambodian P. falciparum NF135.C10 line.
Thu Jun 17 00:00:00 EDT 2021
Topoisomerase 3β knockout mice show transcriptional and behavioural impairments associated with neurogenesis and synaptic plasticity.
Nature communications
Joo Y,Xue Y,Wang Y,McDevitt RA,Sah N,Bossi S,Su S,Lee SK,Peng W,Xie A,Zhang Y,Ding Y,Ku WL,Ghosh S,Fishbein K,Shen W,Spencer R,Becker K,Zhao K,Mattson MP,van Praag H,Sharov A,Wang W
A-21311 was used in Immunohistochemistry to show that Top3β knockout mice exhibit behavioural phenotypes related to psychiatric disorders and cognitive impairment.
Fri Jun 19 00:00:00 EDT 2020
Blood and lymphatic systems are segregated by the FLCN tumor suppressor.
Nature communications
Tai-Nagara I,Hasumi Y,Kusumoto D,Hasumi H,Okabe K,Ando T,Matsuzaki F,Itoh F,Saya H,Liu C,Li W,Mukouyama YS,Marston Linehan W,Liu X,Hirashima M,Suzuki Y,Funasaki S,Satou Y,Furuya M,Baba M,Kubota Y
A-21311 was used in Immunohistochemistry to demonstrate that Folliculin acts as a gatekeeper that maintains separation of blood and lymphatic vessels by limiting the plasticity of committed endothelial cells.
Wed Dec 09 00:00:00 EST 2020
The ELAV/Hu protein Found in neurons regulates cytoskeletal and ECM adhesion inputs for space-filling dendrite growth.
PLoS genetics
Alizzi RA,Xu D,Tenenbaum CM,Wang W,Gavis ER
A-21311 was used in Immunohistochemistry to show that the ELAV/Hu family RNA-binding protein Found in neurons (Fne) is required for space-filling dendrite growth to generate highly branched arbors of Drosophila larval class IV dendritic arborization neurons.
Tue Dec 01 00:00:00 EST 2020
Independent glial subtypes delay development and extend healthy lifespan upon reduced insulin-PI3K signalling.
BMC biology
Woodling NS,Rajasingam A,Minkley LJ,Rizzo A,Partridge L
A-21311 was used in Immunohistochemistry-immunofluorescence to investigate the role of insulin signalling in Drosophilia glial cells.
Mon Sep 14 00:00:00 EDT 2020
Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium.
eLife
Hansen JN,Kaiser F,Klausen C,Stüven B,Chong R,Bönigk W,Mick DU,Möglich A,Jurisch-Yaksi N,Schmidt FI,Wachten D
A-21311 was used in Immunohistochemistry-immunofluorescence to overcome the loss of protein function observed after fusion to ciliary targeting sequences.
Wed Jun 24 00:00:00 EDT 2020
No Evidence that Wnt Ligands Are Required for Planar Cell Polarity in Drosophila.
Cell reports
Ewen-Campen B,Comyn T,Vogt E,Perrimon N
A-21311 was used in Immunohistochemistry to not support the hypothesis that Wnt ligands contribute to PCP signaling in the Drosophila wing or notum.
Tue Sep 08 00:00:00 EDT 2020
Dscam1 establishes the columnar units through lineage-dependent repulsion between sister neurons in the fly brain.
Nature communications
Liu C,Trush O,Han X,Wang M,Takayama R,Yasugi T,Hayashi T,Sato M
A-21311 was used in Immunohistochemistry to show that neurons from the same lineage project to different columns under control of Down syndrome cell adhesion molecule (Dscam) in the fly brain.
Thu Aug 13 00:00:00 EDT 2020
Losing Dnmt3a dependent methylation in inhibitory neurons impairs neural function by a mechanism impacting Rett syndrome.
eLife
Lavery LA,Ure K,Wan YW,Luo C,Trostle AJ,Wang W,Jin H,Lopez J,Lucero J,Durham MA,Castanon R,Nery JR,Liu Z,Goodell M,Ecker JR,Behrens MM,Zoghbi HY
A-21311 was used in Flow Cytometry to investigate whether MeCP2 is the sole reader for Dnmt3a dependent methylation by comparing mice lacking either protein in GABAergic inhibitory neurons.
Wed Mar 11 00:00:00 EDT 2020
Genetic aberrations in iPSCs are introduced by a transient G1/S cell cycle checkpoint deficiency.
Nature communications
Araki R,Hoki Y,Suga T,Obara C,Sunayama M,Imadome K,Fujita M,Kamimura S,Nakamura M,Wakayama S,Nagy A,Wakayama T,Abe M
A-21311 was used in Immunohistochemistry to show a relationship between reprogrammed pluripotent stem cells iPSCs and tumorigenesis.
Fri Jan 10 00:00:00 EST 2020
Myh11+ microvascular mural cells and derived mesenchymal stem cells promote retinal fibrosis.
Scientific reports
Ray HC,Corliss BA,Bruce AC,Kesting S,Dey P,Mansour J,Seaman SA,Smolko CM,Mathews C,Dey BK,Owens GK,Peirce SM,Yates PA
A-21311 was used in Immunohistochemistry-immunofluorescence to show that myofibroblast differentiation of mural cells contributes directly to retinal fibrosis.
Fri Sep 25 00:00:00 EDT 2020
Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow.
Nature communications
Riedel R,Addo R,Ferreira-Gomes M,Heinz GA,Heinrich F,Kummer J,Greiff V,Schulz D,Klaeden C,Cornelis R,Menzel U,Kröger S,Stervbo U,Köhler R,Haftmann C,Kühnel S,Lehmann K,Maschmeyer P,McGrath M,Naundorf S,Hahne S,Sercan-Alp Ö,Siracusa F,Stefanowski J,Weber M,Westendorf K,Zimmermann J,Hauser AE,Reddy ST,Durek P,Chang HD,Mashreghi MF,Radbruch A
A-21311 was used in Immunohistochemistry-immunofluorescence to identify distinct populations of isotype-switched memory B lymphocytes of murine spleen and bone marrow.
Fri May 22 00:00:00 EDT 2020
Id1 and Id3 Maintain Steady-State Hematopoiesis by Promoting Sinusoidal Endothelial Cell Survival and Regeneration.
Cell reports
Gadomski S,Singh SK,Singh S,Sarkar T,Klarmann KD,Berenschot M,Seaman S,Jakubison B,Gudmundsson KO,Lockett S,Keller JR
A-21311 was used in Immunocytochemistry-Immunofluorescence to investigate the effects of loss of ld genes on adult endothelial cell.
Tue Apr 28 00:00:00 EDT 2020
The Susceptibility of Retinal Ganglion Cells to Optic Nerve Injury is Type Specific.
Cells
Yang N,Young BK,Wang P,Tian N
A-21311 was used in Immunohistochemistry to show the susceptibility of these RGC types to ONC varies significantly, in which BD-RGCs are the most resistant RGC type while W3-RGCs are the most sensitive cells to ONC and that the survival rates of BD-RGCs and J-RGCs after ONC are significantly higher than their survival rates after NMDA excitotoxicity.
Tue Mar 10 00:00:00 EDT 2020
yippee like 3 (ypel3) is a novel gene required for myelinating and perineurial glia development.
PLoS genetics
Blanco-Sánchez B,Clément A,Stednitz SJ,Kyle J,Peirce JL,McFadden M,Wegner J,Phillips JB,Macnamara E,Huang Y,Adams DR,Toro C,Gahl WA,Malicdan MCV,Tifft CJ,Zink EM,Bloodsworth KJ,Stratton KG,Koeller DM,Metz TO,Washbourne P,Westerfield M
A-21311 was used in Immunohistochemistry to demonstrate that Ypel3 is a novel gene required for perineurial cell development and glial myelination.
Mon Jun 01 00:00:00 EDT 2020
Commensal-specific T cell plasticity promotes rapid tissue adaptation to injury.
Science (New York, N.Y.)
Harrison OJ,Linehan JL,Shih HY,Bouladoux N,Han SJ,Smelkinson M,Sen SK,Byrd AL,Enamorado M,Yao C,Tamoutounour S,Van Laethem F,Hurabielle C,Collins N,Paun A,Salcedo R,O'Shea JJ,Belkaid Y
A-21311 was used in Immunohistochemistry-immunofluorescence to describe a tissue checkpoint regulated by the plasticity and adaptability of commensal-specific T cells, which allows flexibility in local immunity and tissue adaptation to injury.
Fri Jan 04 00:00:00 EST 2019
MAIT cells are imprinted by the microbiota in early life and promote tissue repair.
Science (New York, N.Y.)
Constantinides MG,Link VM,Tamoutounour S,Wong AC,Perez-Chaparro PJ,Han SJ,Chen YE,Li K,Farhat S,Weckel A,Krishnamurthy SR,Vujkovic-Cvijin I,Linehan JL,Bouladoux N,Merrill ED,Roy S,Cua DJ,Adams EJ,Bhandoola A,Scharschmidt TC,Aubé J,Fischbach MA,Belkaid Y
A-21311 was used in Immunohistochemistry-immunofluorescence to study the development of mucosal-associated invariant T cells and its effect on MAIT cell development using adult cutaneous MAIT cells.
Fri Oct 25 00:00:00 EDT 2019
The Chemoattractant Receptor Ebi2 Drives Intranodal Naive CD4+ T Cell Peripheralization to Promote Effective Adaptive Immunity.
Immunity
Baptista AP,Gola A,Huang Y,Milanez-Almeida P,Torabi-Parizi P,Urban JF,Shapiro VS,Gerner MY,Germain RN
A-21311 was used in Immunohistochemistry-immunofluorescence to demonstrate evolutionary selection for distinct niches within the LN that promote cellular responses, emphasizing the critical link between fine-grained tissue organization and host defense.
Tue May 21 00:00:00 EDT 2019
PTPN2 regulates the generation of exhausted CD8+ T cell subpopulations and restrains tumor immunity.
Nature immunology
LaFleur MW,Nguyen TH,Coxe MA,Miller BC,Yates KB,Gillis JE,Sen DR,Gaudiano EF,Al Abosy R,Freeman GJ,Haining WN,Sharpe AH
A-21311 was used in Flow cytometry/Cell sorting to indicate that increasing the number of cytotoxic Tim-3+CD8+ T cells can promote effective anti-tumor immunity and implicate PTPN2 in immune cells as an attractive cancer immunotherapy target.
Tue Oct 01 00:00:00 EDT 2019
Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis.
Neuron
Sohn PD,Huang CT,Yan R,Fan L,Tracy TE,Camargo CM,Montgomery KM,Arhar T,Mok SA,Freilich R,Baik J,He M,Gong S,Roberson ED,Karch CM,Gestwicki JE,Xu K,Kosik KS,Gan L
A-21311 was used in Immunocytochemistry-immunoflourescence to expand our understanding of how FTD-causing tau mutations dysregulate components of the neuronal cytoskeleton, leading to network dysfunction.
Wed Nov 06 00:00:00 EST 2019
A Neural Circuit Encoding the Experience of Copulation in Female Drosophila.
Neuron
Shao L,Chung P,Wong A,Siwanowicz I,Kent CF,Long X,Heberlein U
A-21311 was used in Immunohistochemistry to investigate the effect of coital sensory inputs from those of male Drosophila ejaculate.
Wed Jun 05 00:00:00 EDT 2019
Gene therapy targeting SARM1 blocks pathological axon degeneration in mice.
The Journal of experimental medicine
Geisler S,Huang SX,Strickland A,Doan RA,Summers DW,Mao X,Park J,DiAntonio A,Milbrandt J
A-21311 was used in Immunohistochemistry to develop a novel AAV-mediated gene therapy capable of blocking axonal degeneration through the inhibition of SARM1.
Mon Feb 04 00:00:00 EST 2019
PML nuclear body-residing proteins sequentially associate with HPV genome after infectious nuclear delivery.
PLoS pathogens
Guion L,Bienkowska-Haba M,DiGiuseppe S,Florin L,Sapp M
A-21311 was used in Immunocytochemistry-immunoflourescence to test the hypothesis that PML protein is recruited to incoming viral genome prior to egress from transport vesicles.
Fri Feb 01 00:00:00 EST 2019
Endogenous Tagging Reveals Differential Regulation of Ca2+ Channels at Single Active Zones during Presynaptic Homeostatic Potentiation and Depression.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Gratz SJ,Goel P,Bruckner JJ,Hernandez RX,Khateeb K,Macleod GT,Dickman D,O'Connor-Giles KM
A-21311 was used in Immunohistochemistry-immunofluorescence to study the regulation of endogenous Ca2+ channels during homeostatic plasticity.
Wed Mar 27 00:00:00 EDT 2019
Knockdown of Fidgetin Improves Regeneration of Injured Axons by a Microtubule-Based Mechanism.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Matamoros AJ,Tom VJ,Wu D,Rao Y,Sharp DJ,Baas PW
A-21311 was used in Immunocytochemistry to establish fidgetin as a novel therapeutic target to augment nerve regeneration and provide a workflow template by which microtubule-related targets can be compared in the future.
Wed Mar 13 00:00:00 EDT 2019
Pedunculopontine Glutamatergic Neurons Provide a Novel Source of Feedforward Inhibition in the Striatum by Selectively Targeting Interneurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Assous M,Dautan D,Tepper JM,Mena-Segovia J
A-21311 was used in Immunocytochemistry-immunoflourescence to report the existence of a glutamatergic projection from the mesencephalic locomotor region to the striatum that avoids the spiny neurons and selectively innervates interneurons.
Wed Jun 12 00:00:00 EDT 2019
A Non-Canonical Cortico-Amygdala Inhibitory Loop.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Bertero A,Feyen PLC,Zurita H,Apicella AJ
A-21311 was used in Immunohistochemistry-immunofluorescence to show that the lateral amygdala receives long-range GABAergic projection from the auditory cortex and these form direct monosynaptic inhibitory connections onto lateral amygdala principal neurons.
Wed Oct 23 00:00:00 EDT 2019
A dileucine motif in the COOH-terminal domain of NKCC1 targets the cotransporter to the plasma membrane.
American journal of physiology. Cell physiology
Koumangoye R,Omer S,Delpire E
A-21311 was used in Immunocytochemistry-immunoflourescence to show, in the absence of the dileucine motif at the COOH domain, NKCC1 targets are trafficked out of the endoplasmic reticulum and trans-Golgi network and accumulated in endosomes for degradation.
Mon Apr 01 00:00:00 EDT 2019
Quantitative proteomics identifies proteins that resist translational repression and become dysregulated in ALS-FUS.
Human molecular genetics
Baron DM,Matheny T,Lin YC,Leszyk JD,Kenna K,Gall KV,Santos DP,Tischbein M,Funes S,Hayward LJ,Kiskinis E,Landers JE,Parker R,Shaffer SA,Bosco DA
A-21311 was used in Immunocytochemistry-Immunofluorescence to suggest that Golgi to ER retrograde transport may be important under conditions of stress and is perturbed upon the expression of disease-linked proteins such as FUS.
Mon Jul 01 00:00:00 EDT 2019
Retinal Characterization of the Thy1-GCaMP3 Transgenic Mouse Line After Optic Nerve Transection.
Investigative ophthalmology & visual science
Blandford SN,Hooper ML,Yabana T,Chauhan BC,Baldridge WH,Farrell SRM
A-21311 was used in Immunohistochemistry to determine the specificity of GCaMP3 expression in the Thy1-GCaMP3 transgenic mouse retina.
Wed Jan 02 00:00:00 EST 2019
Ano1 mediates pressure-sensitive contraction frequency changes in mouse lymphatic collecting vessels.
The Journal of general physiology
Zawieja SD,Castorena JA,Gui P,Li M,Bulley SA,Jaggar JH,Rock JR,Davis MJ
A-21311 was used in Immunocytochemistry-immunoflourescence to show that the canonical CaCC Anoctamin 1 (Ano1, TMEM16a) plays an important role in lymphatic smooth muscle pacemaking.
Mon Apr 01 00:00:00 EDT 2019
Prickle1 is required for EMT and migration of zebrafish cranial neural crest.
Developmental biology
Ahsan K,Singh N,Rocha M,Huang C,Prince VE
A-21311 was used in Immunohistochemistry to demonstrate that zebrafish Pk1 is required during cranial neural crest EMT and migration.
Mon Apr 01 00:00:00 EDT 2019
Brown Fat Promotes Muscle Growth During Regeneration.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Bryniarski AR,Meyer GA
A-21311 was used in Immunohistochemistry to describe a novel intermuscular fat transplant model in the mouse rotator cuff to investigate cross-talk between muscle and adipose tissue.
Thu Aug 01 00:00:00 EDT 2019
Multiple cell types form the VIP amacrine cell population.
The Journal of comparative neurology
Pérez de Sevilla Müller L,Solomon A,Sheets K,Hapukino H,Rodriguez AR,Brecha NC
A-21311 was used in Immunohistochemistry-immunofluorescence to characterise the morphology, neurochemistry and major cell types of a VIP-ires-Cre amacrine cell population.
Tue Jan 01 00:00:00 EST 2019
The Susceptibility of Retinal Ganglion Cells to Glutamatergic Excitotoxicity Is Type-Specific.
Frontiers in neuroscience
Christensen I,Lu B,Yang N,Huang K,Wang P,Tian N
A-21311 was used in Immunohistochemistry-immunofluorescence to characterise the susceptibility of retinal ganglion cells types to NMDA-induced excitotoxicity.
Thu May 12 00:00:00 EDT 2022
The RNA-binding protein FUS/TLS undergoes calcium-mediated nuclear egress during excitotoxic stress and is required for GRIA2 mRNA processing.
The Journal of biological chemistry
Tischbein M,Baron DM,Lin YC,Gall KV,Landers JE,Fallini C,Bosco DA
A-21311 was used in Immunohistochemistry to explore the relationships between excitotoxicity, RBP function, and neurological disorders.
Fri Jun 28 00:00:00 EDT 2019
A genome-wide assessment of the ancestral neural crest gene regulatory network.
Nature communications
Hockman D,Chong-Morrison V,Green SA,Gavriouchkina D,Candido-Ferreira I,Ling ITC,Williams RM,Amemiya CT,Smith JJ,Bronner ME,Sauka-Spengler T
A-21311 was used in Immunohistochemistry-immunofluorescence to provide insight into the core gene regulatory network (GRN) elements conserved to the base of the vertebrates and expose others that are unique to lampreys.
Wed Oct 16 00:00:00 EDT 2019
Neuronal network remodeling and Wnt pathway dysregulation in the intra-hippocampal kainate mouse model of temporal lobe epilepsy.
PloS one
Gupta K,Schnell E
A-21311 was used in Immunohistochemistry to demonstrate regional variation in Wnt pathway dysregulation early after seizure induction.
Tue Mar 10 00:00:00 EDT 2020
In vivo Ca2+ imaging of astrocytic microdomains reveals a critical role of the amyloid precursor protein for mitochondria.
Glia
Montagna E,Crux S,Luckner M,Herber J,Colombo AV,Marinković P,Tahirovic S,Lichtenthaler SF,Wanner G,Müller UC,Sgobio C,Herms J
A-21311 was used in Immunohistochemistry-immunofluorescence to provide novel insights in APP physiological functions which are important for the understanding of the effects of drugs validated in Alzheimer's disease treatment that affect the function of APP.
Wed May 01 00:00:00 EDT 2019
Glial Ca2+signaling links endocytosis to K+ buffering around neuronal somas to regulate excitability.
eLife
Weiss S,Melom JE,Ormerod KG,Zhang YV,Littleton JT
A-21311 was used in Immunocytochemistry to show that elevation of glial Ca2+ causes hyperactivation of calcineurin-dependent endocytosis and accumulation of early endosomes.
Fri Apr 26 00:00:00 EDT 2019
Generating Vegfr3 reporter transgenic mouse expressing membrane-tagged Venus for visualization of VEGFR3 expression in vascular and lymphatic endothelial cells.
PloS one
Watanabe C,Matsushita J,Azami T,Tsukiyama-Fujii S,Tsukiyama T,Mizuno S,Takahashi S,Ema M
A-21311 was used in Immunohistochemistry to show that this Tg mouse line contributes a valuable model to study angiogenesis and lymphangiogenesis in physiological and pathological contexts.
Mon Sep 30 00:00:00 EDT 2019
A Novel Tool for the Generation of Conditional Knockouts To Study Gene Function across the Plasmodium falciparum Life Cycle.
mBio
Tibúrcio M,Yang ASP,Yahata K,Suárez-Cortés P,Belda H,Baumgarten S,van de Vegte-Bolmer M,van Gemert GJ,van Waardenburg Y,Levashina EA,Sauerwein RW,Treeck M
A-21311 was used in Immunohistochemistry to describe the detailed characterization of a new marker-free P. falciparum parasite line that expresses rapamycin-inducible Cre recombinase across the full life cycle.
Tue Sep 17 00:00:00 EDT 2019
A circuit from hippocampal CA2 to lateral septum disinhibits social aggression.
Nature
Leroy F,Park J,Asok A,Brann DH,Meira T,Boyle LM,Buss EW,Kandel ER,Siegelbaum SA
A-21311 was used in Immunocytochemistry to study how hippocampal output regulates motivated behaviours.
Sat Dec 01 00:00:00 EST 2018
Genetic Rescue Reverses Microglial Activation in Preclinical Models of Retinitis Pigmentosa.
Molecular therapy : the journal of the American Society of Gene Therapy
Zhang L,Cui X,Jauregui R,Park KS,Justus S,Tsai YT,Duong JK,Hsu CW,Wu WH,Xu CL,Lin CS,Tsang SH
A-21311 was used in Immunohistochemistry-immunofluorescence to suggest that halting long-term disease progression may be more successful by downregulating MGC activity while co-administering the therapeutic intervention.
Wed Aug 01 00:00:00 EDT 2018
The cJUN NH2-terminal kinase (JNK) pathway contributes to mouse mammary gland remodeling during involution.
Cell death and differentiation
Girnius N,Edwards YJK,Davis RJ
A-21311 was used in Immunohistochemistry to study the role of JUN NH2-terminal kinase in mammary gland involution post lactation.
Sat Sep 01 00:00:00 EDT 2018
Distinct Circuits for Recovery of Eye Dominance and Acuity in Murine Amblyopia.
Current biology : CB
Stephany CÉ,Ma X,Dorton HM,Wu J,Solomon AM,Frantz MG,Qiu S,McGee AW
A-21311 was used in Immunohistochemistry to demonstrate that plasticity of eye dominance and acuity are independent and restricted by the nogo-66 receptor (ngr1) in distinct neuronal populations.
Mon Jun 18 00:00:00 EDT 2018
Spatial Memory Engram in the Mouse Retrosplenial Cortex.
Current biology : CB
Milczarek MM,Vann SD,Sengpiel F
A-21311 was used in Immunohistochemistry-immunofluorescence to identify spatial memory engrams in the mouse retrosplenial cortex which become progressively more stable with learning and are maintained over several weeks.
Mon Jun 18 00:00:00 EDT 2018
PAR-3 controls endothelial planar polarity and vascular inflammation under laminar flow.
EMBO reports
Hikita T,Mirzapourshafiyi F,Barbacena P,Riddell M,Pasha A,Li M,Kawamura T,Brandes RP,Hirose T,Ohno S,Gerhardt H,Matsuda M,Franco CA,Nakayama M
A-21311 was used in Immunocytochemistry-immunoflourescence to show, in response to laminar blood flow, cell polarity protein PAR-3 has an essential role as a gatekeeper of GSK3β activity.
Sat Sep 01 00:00:00 EDT 2018
Optogenetic activation of 5-HT neurons in the dorsal raphe suppresses seizure-induced respiratory arrest and produces anticonvulsant effect in the DBA/1 mouse SUDEP model.
Neurobiology of disease
Zhang H,Zhao H,Zeng C,Van Dort C,Faingold CL,Taylor NE,Solt K,Feng HJ
A-21311 was used in Immunohistochemistry to study the mechanisms underlying seizure induced respiratory arrest.
Thu Feb 01 00:00:00 EST 2018
Overlapping Role of SCYL1 and SCYL3 in Maintaining Motor Neuron Viability.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Kuliyev E,Gingras S,Guy CS,Howell S,Vogel P,Pelletier S
A-21311 was used in Immunocytochemistry to show that SCYL1 and SCYL3 play overlapping roles in maintaining motor neuronal viability in vivo and confirm that SCYL family members are critical regulators of neuronal function and survival.
Wed Mar 07 00:00:00 EST 2018
Preferential Targeting of Lateral Entorhinal Inputs onto Newly Integrated Granule Cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Woods NI,Vaaga CE,Chatzi C,Adelson JD,Collie MF,Perederiy JV,Tovar KR,Westbrook GL
A-21311 was used in Immunohistochemistry to demonstrate that these neurons preferentially receive information thought to convey the context of an experience.
Wed Jun 27 00:00:00 EDT 2018
Lineage-Specific Wnt Reporter Elucidates Mesenchymal Wnt Signaling during Bone Repair.
The American journal of pathology
Chang L,Zhang L,Xu J,Meyers CA,Li Z,Yan N,Zou E,James AW
A-21311 was used in Immunohistochemistry to tackle the issue of tissue-specific Wnt signaling by generating and characterising a transgenic mouse strain.
Mon Oct 01 00:00:00 EDT 2018
Characterization of centriole duplication in human epidermis, Bowen's disease, and squamous cell carcinoma.
Journal of dermatological science
Watanuki S,Fujita H,Kouyama K,Amagai M,Kubo A
A-21311 was used in Immunocytochemistry-immunoflourescence to characterise centrosome duplication in human epidermis, Bowen's disease and squamous cell carcinoma using immunofluorescence.
Sun Jul 01 00:00:00 EDT 2018
Mistargeting of a truncated Na-K-2Cl cotransporter in epithelial cells.
American journal of physiology. Cell physiology
Koumangoye R,Omer S,Delpire E
A-21311 was used in Immunohistochemistry to examine expression of the mutant cotransporter in epithelial cells.
Wed Aug 01 00:00:00 EDT 2018
High-throughput three-dimensional chemotactic assays reveal steepness-dependent complexity in neuronal sensation to molecular gradients.
Nature communications
Xu Z,Fang P,Xu B,Lu Y,Xiong J,Gao F,Wang X,Fan J,Shi P
A-21311 was used in Immunocytochemistry to provide insights to the critical role of gradient steepness in neuronal chemotaxis, and also prove the technique as an expandable platform for studying other chemoresponsive cellular systems.
Mon Nov 12 00:00:00 EST 2018
Regulation of cortical activity and arousal by the matrix cells of the ventromedial thalamic nucleus.
Nature communications
Honjoh S,Sasai S,Schiereck SS,Nagai H,Tononi G,Cirelli C
A-21311 was used in Immunohistochemistry to show in mice that the activity of VM calbindin1-positive matrix cells is high in wake and REM sleep and low in NREM sleep, and increases before cortical activity at the sleep-to-wake transition.
Tue May 29 00:00:00 EDT 2018
Spatiotemporal regulation of Aurora B recruitment ensures release of cohesion during C. elegans oocyte meiosis.
Nature communications
Ferrandiz N,Barroso C,Telecan O,Shao N,Kim HM,Testori S,Faull P,Cutillas P,Snijders AP,Colaiácovo MP,Martinez-Perez E
A-21311 was used in Immunohistochemistry-immunofluorescence to elucidate a complex regulatory network that uses chromosome axis components, H3 T3 phosphorylation, and cell cycle regulators to ensure accurate chromosome segregation during oogenesis.
Mon Feb 26 00:00:00 EST 2018
Synthetic matrix enhances transplanted satellite cell engraftment in dystrophic and aged skeletal muscle with comorbid trauma.
Science advances
Han WM,Anderson SE,Mohiuddin M,Barros D,Nakhai SA,Shin E,Amaral IF,Pêgo AP,García AJ,Jang YC
A-21311 was used in Immunocytochemistry-immunoflourescence to demonstrate that delivery of MuSCs in the engineered matrix may be a suitable platform for treating craniofacial and limb muscle trauma, as well as postoperative wounds of elderly and dystrophic patients.
Wed Aug 01 00:00:00 EDT 2018
The AMPK/p27Kip1 Axis Regulates Autophagy/Apoptosis Decisions in Aged Skeletal Muscle Stem Cells.
Stem cell reports
White JP,Billin AN,Campbell ME,Russell AJ,Huffman KM,Kraus WE
A-21311 was used in Immunohistochemistry-immunofluorescence to investigate how Skeletal Muscle Stem Cell function changes with age by exploring the AMPK/p27Kip1 pathway (a mix of flow cytometry, immunofluorsecence and western blot were used in this study).
Tue Aug 14 00:00:00 EDT 2018
Targeted Activation of Cholinergic Interneurons Accounts for the Modulation of Dopamine by Striatal Nicotinic Receptors.
eNeuro
Brimblecombe KR,Threlfell S,Dautan D,Kosillo P,Mena-Segovia J,Cragg SJ
A-21311 was used in Immunohistochemistry to establish how ACh drives striatal dopamine release in regards to whether Chls alone and/or brainstem afferents to the striatum.
Fri Apr 19 00:00:00 EDT 2019
14-3-3σ Protein Expression in Canine Renal Cell Carcinomas.
Veterinary pathology
Suárez-Bonnet A,Lara-García A,Stoll AL,Carvalho S,Priestnall SL
A-21311 was used in Immunohistochemistry-immunofluorescence to suggest that 14-3-3σ is a potential negative prognostic factor and a possible therapeutic target.
Thu Mar 01 00:00:00 EST 2018
Glutamate Activity Regulates and Dendritic Development of J-RGCs.
Frontiers in cellular neuroscience
Elias E,Yang N,Wang P,Tian N
A-21311 was used in Immunohistochemistry-wholemount to study the role of glutamate receptor activity on dendritic development of retinal ganglion cells.
Thu May 12 00:00:00 EDT 2022
miR-10a rejuvenates aged human mesenchymal stem cells and improves heart function after myocardial infarction through KLF4.
Stem cell research & therapy
Dong J,Zhang Z,Huang H,Mo P,Cheng C,Liu J,Huang W,Tian C,Zhang C,Li J
A-21311 was used in Immunohistochemistry-immunofluorescence to demonstrate how the upregulation of miR-10a in aged human mesenchymal stem cells reduces age-related characteristics through the suppression of KLF4.
Wed May 30 00:00:00 EDT 2018
Genetic Control of Rod Bipolar Cell Number in the Mouse Retina.
Frontiers in neuroscience
Kautzman AG,Keeley PW,Borhanian S,Ackley CR,Reese BE
A-21311 was used in Immunohistochemistry to demonstrate the involvement of Ggct (gamma-glutamyl cyclotransferase) gene expression in modulating the number of rod bipolar cells in the mouse retina.
Thu Oct 01 00:00:00 EDT 2020
Tcf4 regulates dendritic spine density and morphology in the adult brain.
PloS one
Crux S,Herms J,Dorostkar MM
A-21311 was used in Immunohistochemistry to show that transcription factor, Tcf4, is involved in synaptic plasticity of mature neurons, and functional loss of Tcf4 may contribute to the neurological symptoms of Pitt-Hopkins syndrome.
Mon Apr 15 00:00:00 EDT 2019
A hippocampal circuit linking dorsal CA2 to ventral CA1 critical for social memory dynamics.
Nature communications
Meira T,Leroy F,Buss EW,Oliva A,Park J,Siegelbaum SA
A-21311 was used in Immunohistochemistry to provide new insights into a dorsal CA2 to ventral CA1 circuit whose dynamic activity is necessary for social memory.
Tue Oct 09 00:00:00 EDT 2018
Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury.
Nature communications
Lazzeri E,Angelotti ML,Peired A,Conte C,Marschner JA,Maggi L,Mazzinghi B,Lombardi D,Melica ME,Nardi S,Ronconi E,Sisti A,Antonelli G,Becherucci F,De Chiara L,Guevara RR,Burger A,Schaefer B,Annunziato F,Anders HJ,Lasagni L,Romagnani P
A-21311 was used in Flow cytometry/Cell sorting to deduce that limited progenitor-driven regeneration and remnant tubular cell hypertrophy involves renal functional recovery upon acute kidney injury.
Mon Apr 09 00:00:00 EDT 2018
Xkr8 Modulates Bipolar Cell Number in the Mouse Retina.
Frontiers in neuroscience
Kautzman AG,Keeley PW,Ackley CR,Leong S,Whitney IE,Reese BE
A-21311 was used in Immunohistochemistry to interrogate a quantitative trait locus on Chr 4 associated with the population sizes of two types of bipolar cell in the mouse retina.
Tue Sep 29 00:00:00 EDT 2020
Renal Sodium Gradient Orchestrates a Dynamic Antibacterial Defense Zone.
Cell
Berry MR,Mathews RJ,Ferdinand JR,Jing C,Loudon KW,Wlodek E,Dennison TW,Kuper C,Neuhofer W,Clatworthy MR
A-21311 was used in Immunocytochemistry to reveal a critical accessory role for the homeostatic function of a vital organ in optimizing tissue defense.
Thu Aug 24 00:00:00 EDT 2017
Reactive Neutrophil Responses Dependent on the Receptor Tyrosine Kinase c-MET Limit Cancer Immunotherapy.
Immunity
Glodde N,Bald T,van den Boorn-Konijnenberg D,Nakamura K,O'Donnell JS,Szczepanski S,Brandes M,Eickhoff S,Das I,Shridhar N,Hinze D,Rogava M,van der Sluis TC,Ruotsalainen JJ,Gaffal E,Landsberg J,Ludwig KU,Wilhelm C,Riek-Burchardt M,Müller AJ,Gebhardt C,Scolyer RA,Long GV,Janzen V,Teng MWL,Kastenmüller W,Mazzone M,Smyth MJ,Tüting T,Hölzel M
A-21311 was used in Immunocytochemistry to reveal a role for the HGF/c-MET pathway in neutrophil recruitment and function and suggest that c-MET inhibitor co-treatment may improve responses to cancer immunotherapy in settings beyond c-MET-dependent tumors.
Tue Oct 17 00:00:00 EDT 2017
Mutant α2-chimaerin signals via bidirectional ephrin pathways in Duane retraction syndrome.
The Journal of clinical investigation
Nugent AA,Park JG,Wei Y,Tenney AP,Gilette NM,DeLisle MM,Chan WM,Cheng L,Engle EC
A-21311 was used in Immunohistochemistry to reveal a role for ephrin bidirectional signaling upstream of mutant α2-chimaerin in DRS, which may contribute to the selective vulnerability of abducens motor neurons in this disorder.reveal a role for ephrin bidirectional signaling upstream of mutant α2-chimaerin in DRS, which may contribute to the selective vulnerability of abducens motor neurons in this disorder.
Mon May 01 00:00:00 EDT 2017
Cell Cycle Control by Nuclear Sequestration of CDC20 and CDH1 mRNA in Plant Stem Cells.
Molecular cell
Yang W,Wightman R,Meyerowitz EM
A-21311 was used in Immunohistochemistry to study the expression and role of APC/C coactivator genes CDC20 and CCS52B in cell cycle control in Arabidopsis.
Thu Dec 21 00:00:00 EST 2017
Input-Specific Plasticity and Homeostasis at the Drosophila Larval Neuromuscular Junction.
Neuron
Newman ZL,Hoagland A,Aghi K,Worden K,Levy SL,Son JH,Lee LP,Isacoff EY
A-21311 was used in Immunohistochemistry-immunofluorescence to conclude that basal synaptic strength, short-term plasticity, and homeostasis are determined input-specifically, generating a functional diversity that sculpts excitatory transmission and behavioral function.
Wed Mar 22 00:00:00 EDT 2017
The Spatiotemporal Organization of the Striatum Encodes Action Space.
Neuron
Klaus A,Martins GJ,Paixao VB,Zhou P,Paninski L,Costa RM
A-21311 was used in Immunohistochemistry to identify toluidine blue as a potent molecule against Alzheimer's disease by inhibiting aggregation of Tau-mediated pathology.
Wed Aug 30 00:00:00 EDT 2017
Development and Refinement of Functional Properties of Adult-Born Neurons.
Neuron
Wallace JL,Wienisch M,Murthy VN
A-21311 was used in Immunohistochemistry to show rapid integration of adult-born neurons into existing circuits followed by experience-dependent refinement of their functional connectivity.
Wed Nov 15 00:00:00 EST 2017
The Function and Organization of the Motor System Controlling Flight Maneuvers in Flies.
Current biology : CB
Lindsay T,Sustar A,Dickinson M
A-21311 was used in Immunohistochemistry to determine mechanisms by which animals execute precise actions using sparse motor networks.
Mon Feb 06 00:00:00 EST 2017
Fife organizes synaptic vesicles and calcium channels for high-probability neurotransmitter release.
The Journal of cell biology
Bruckner JJ,Zhan H,Gratz SJ,Rao M,Ukken F,Zilberg G,O'Connor-Giles KM
A-21311 was used in Immunohistochemistry-immunofluorescence to identify the role of Fife in the organisation of and release of synaptic vessicles, and associated calcium channels. Electron tomographic and electrophysiological studies were used in Drosophila melanogaster.
Mon Jan 02 00:00:00 EST 2017
A quantitative brain map of experimental cerebral malaria pathology.
PLoS pathogens
Strangward P,Haley MJ,Shaw TN,Schwartz JM,Greig R,Mironov A,de Souza JB,Cruickshank SM,Craig AG,Milner DA,Allan SM,Couper KN
A-21311 was used in Immunohistochemistry-immunofluorescence to show for the first time that mature parasitised red blood cells accumulate within the cerebral capillaries during experimental cerebral malaria.
Wed Mar 01 00:00:00 EST 2017
Placental labyrinth formation in mice requires endothelial FLRT2/UNC5B signaling.
Development (Cambridge, England)
Tai-Nagara I,Yoshikawa Y,Numata N,Ando T,Okabe K,Sugiura Y,Ieda M,Takakura N,Nakagawa O,Zhou B,Okabayashi K,Suematsu M,Kitagawa Y,Bastmeyer M,Sato K,Klein R,Navankasattusas S,Li DY,Yamagishi S,Kubota Y
A-21311 was used in Immunohistochemistry to suggest that the proper organization of the placental labyrinth depends on coordinated inter-endothelial repulsion, which prevents uncontrolled layering of the endothelium.
Sat Jul 01 00:00:00 EDT 2017
Interfering of the Reelin/ApoER2/PSD95 Signaling Axis Reactivates Dendritogenesis of Mature Hippocampal Neurons.
Journal of cellular physiology
Ampuero E,Jury N,Härtel S,Marzolo MP,van Zundert B
A-21311 was used in immunocytochemistry to test if impairment of reelin signaling in adult neurons reactivates the dendritic architecture
Mon May 01 00:00:00 EDT 2017
Keratin 8/18 regulation of insulin receptor signaling and trafficking in hepatocytes through a concerted phosphoinositide-dependent Akt and Rab5 modulation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Roux A,Loranger A,Lavoie JN,Marceau N
A-21311 was used in Western Blotting to investigate the role of K8/K18 intermediate filaments in the regulation of insulin receptor signalling and trafficking in hepatocytes.
Tue Aug 01 00:00:00 EDT 2017
Keratin 8/18 regulation of insulin receptor signaling and trafficking in hepatocytes through a concerted phosphoinositide-dependent Akt and Rab5 modulation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Roux A,Loranger A,Lavoie JN,Marceau N
A-21311 was used in Western Blotting to investigate the role of K8/K18 intermediate filaments in the regulation of insulin receptor signalling and trafficking in hepatocytes.
Tue Aug 01 00:00:00 EDT 2017
Unique cell biological profiles of retinal disease-causing missense mutations in the polarity protein Crumbs.
Journal of cell science
Pellikka M,Tepass U
A-21311 was used in Immunohistochemistry to determine the function of the extracellular region of CRB1.
Sat Jul 01 00:00:00 EDT 2017
Thalamic inputs to dorsomedial striatum are involved in inhibitory control: evidence from the five-choice serial reaction time task in rats.
Psychopharmacology
Saund J,Dautan D,Rostron C,Urcelay GP,Gerdjikov TV
A-21311 was used in Immunohistochemistry-immunofluorescence to investigate the role of parafascicular thalamic inputs to the dorsomedial striatum in rats.
Tue Aug 01 00:00:00 EDT 2017
Quantitative Analysis of Supporting Cell Subtype Labeling Among CreER Lines in the Neonatal Mouse Cochlea.
Journal of the Association for Research in Otolaryngology : JARO
McGovern MM,Brancheck J,Grant AC,Graves KA,Cox BC
A-21311 was used in Immunohistochemistry to test if altering the tamoxifen dose would modify CreER expression and target subsets of supporting cells.
Sat Apr 01 00:00:00 EDT 2017
RD26 mediates crosstalk between drought and brassinosteroid signalling pathways.
Nature communications
Ye H,Liu S,Tang B,Chen J,Xie Z,Nolan TM,Jiang H,Guo H,Lin HY,Li L,Wang Y,Tong H,Zhang M,Chu C,Li Z,Aluru M,Aluru S,Schnable PS,Yin Y
A21311 was used in western blot to determine RD26 interacts with BES1 protein to antagonize BES1 transcriptional activity on brassinosteroid-regulated genes
Fri Feb 24 00:00:00 EST 2017
Identification of a hybrid myocardial zone in the mammalian heart after birth.
Nature communications
Tian X,Li Y,He L,Zhang H,Huang X,Liu Q,Pu W,Zhang L,Li Y,Zhao H,Wang Z,Zhu J,Nie Y,Hu S,Sedmera D,Zhong TP,Yu Y,Zhang L,Yan Y,Qiao Z,Wang QD,Wu SM,Pu WT,Anderson RH,Zhou B
A-21311 was used in Immunohistochemistry-immunofluorescence to show that cardiomyocytes in the foetal compact layer contribute to forming a hybrid myocardial zone that is composed of cells derived from both trabecular and compact layers.
Thu Jul 20 00:00:00 EDT 2017
Ttc21b Is Required in Bergmann Glia for Proper Granule Cell Radial Migration.
Journal of developmental biology
Driver AM,Shumrick C,Stottmann RW
A-21311 was used in Immunohistochemistry to determine the role of Tetratricopeptide Repeat Domain 21B (Ttc21b) in cerebellar development.
Tue Dec 19 00:00:00 EST 2017
Neurogenesis from Sox2 expressing cells in the adult cerebellar cortex.
Scientific reports
Ahlfeld J,Filser S,Schmidt F,Wefers AK,Merk DJ,Glaß R,Herms J,Schüller U
A-21311 was used in Immunohistochemistry (Paraffin) to identify an undifferentiated cell population that's intermingled with the Bergmann glia of the adult murine cerebellar cortex, expressing stem cell markers, and lacking markers of glial or neuronal differentiation.
Fri Jul 21 00:00:00 EDT 2017
Enclosure of Dendrites by Epidermal Cells Restricts Branching and Permits Coordinated Development of Spatially Overlapping Sensory Neurons.
Cell reports
Tenenbaum CM,Misra M,Alizzi RA,Gavis ER
A-21311 was used in Immunohistochemistry-immunofluorescence to propose that enclosure of dendrites by epidermal cells is a developmental mechanism for coordinated innervation of shared receptive fields.
Tue Sep 26 00:00:00 EDT 2017
Pathways to clinical CLARITY: volumetric analysis of irregular, soft, and heterogeneous tissues in development and disease.
Scientific reports
Hsueh B,Burns VM,Pauerstein P,Holzem K,Ye L,Engberg K,Wang AC,Gu X,Chakravarthy H,Arda HE,Charville G,Vogel H,Efimov IR,Kim S,Deisseroth K
A-21311 was used in CLARITY to study via high-throughput methods the quantitative volumetric interrogation of spatially-irregular and friable tissue structures.
Wed Jul 19 00:00:00 EDT 2017
Targeting cancer stem cell propagation with palbociclib, a CDK4/6 inhibitor: Telomerase drives tumor cell heterogeneity.
Oncotarget
Bonuccelli G,Peiris-Pages M,Ozsvari B,Martinez-Outschoorn UE,Sotgia F,Lisanti MP
A-21311 was used in Immunohistochemistry-immunofluorescence to study the effect of drugs such as doxycycline and palbociclib in reducing cancer stem cell populations.
Tue Feb 07 00:00:00 EST 2017
A Population of Projection Neurons that Inhibits the Lateral Horn but Excites the Antennal Lobe through Chemical Synapses in Drosophila.
Frontiers in neural circuits
Shimizu K,Stopfer M
A-21311 was used in Immunohistochemistry to investigate the functional roles of ventral projection neurons (vPNs) in the antennal lobe (AL) through the use of optogenetic and patch clamp techniques.
Wed Mar 07 00:00:00 EST 2018
Evolution of Osteocrin as an activity-regulated factor in the primate brain.
Nature
Ataman B,Boulting GL,Harmin DA,Yang MG,Baker-Salisbury M,Yap EL,Malik AN,Mei K,Rubin AA,Spiegel I,Durresi E,Sharma N,Hu LS,Pletikos M,Griffith EC,Partlow JN,Stevens CR,Adli M,Chahrour M,Sestan N,Walsh CA,Berezovskii VK,Livingstone MS,Greenberg ME
A-21311 was used in Immunocytochemistry to suggest that, in response to sensory input, OSTN regulates features of neuronal structure and function that are unique to primates.
Thu Nov 10 00:00:00 EST 2016
A neuronal circuit for colour vision based on rod-cone opponency.
Nature
Joesch M,Meister M
A-21311 was used in immunohistochemistry to study rod-cone opponency as a neuronal circuit for colour vision
Thu Apr 14 00:00:00 EDT 2016
Oligodendrocyte death results in immune-mediated CNS demyelination.
Nature neuroscience
Traka M,Podojil JR,McCarthy DP,Miller SD,Popko B
A-21311 was used in immunohistochemistry to research the connection between oligodendrocyte death and immune-mediated CNS demyelination
Fri Jan 01 00:00:00 EST 2016
Rab10-Mediated Secretion Synergizes with Tissue Movement to Build a Polarized Basement Membrane Architecture for Organ Morphogenesis.
Developmental cell
Isabella AJ,Horne-Badovinac S
A-21311 was used in Immunohistochemistry-immunofluorescence to study how regulated protein secretion can synergise with tissue movement to build a polarised basement membrane architecture that controls tissue shape.
Mon Jul 11 00:00:00 EDT 2016
Adenomatous polyposis coli regulates radial axonal sorting and myelination in the PNS.
Development (Cambridge, England)
Elbaz B,Traka M,Kunjamma RB,Dukala D,Brosius Lutz A,Anton ES,Barres BA,Soliven B,Popko B
A-21311 was used in immunohistochemistry - frozen section to study regulation of radial axonal sorting and myelination in the PNS by adenomatous polyposis coli
Fri Jul 01 00:00:00 EDT 2016
Nanos-mediated repression of hid protects larval sensory neurons after a global switch in sensitivity to apoptotic signals.
Development (Cambridge, England)
Bhogal B,Plaza-Jennings A,Gavis ER
A-21311 was used in immunocytochemistry to study protection of larval sensory neurons after a global switch in sensitivity to apoptotic signals by nanos-mediated repression of hid
Wed Jun 15 00:00:00 EDT 2016
Sorbs1 and -2 Interact with CrkL and Are Required for Acetylcholine Receptor Cluster Formation.
Molecular and cellular biology
Hallock PT,Chin S,Blais S,Neubert TA,Glass DJ
A-21311 was used in immunohistochemistry to elucidate acetylcholine receptor cluster formation and the requirement of Sorbs1 and -2 interacting with CrkL
Fri Jan 15 00:00:00 EST 2016
Featured Article: Nuclear export of opioid growth factor receptor is CRM1 dependent.
Experimental biology and medicine (Maywood, N.J.)
Kren NP,Zagon IS,McLaughlin PJ
A-21311 was used in immunocytochemistry to identify the nuclear export signal for opioid growth factor receptor.
Mon Feb 01 00:00:00 EST 2016
Extrinsic Sources of Cholinergic Innervation of the Striatal Complex: A Whole-Brain Mapping Analysis.
Frontiers in neuroanatomy
Dautan D,Hacioğlu Bay H,Bolam JP,Gerdjikov TV,Mena-Segovia J
A-21311 was used in immunohistochemistry to elucidate whole-brain mapping analysis for extrinsic sources of cholinergic innervation of the striatal complex
Tue Feb 02 00:00:00 EST 2016
Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun.
Developmental dynamics : an official publication of the American Association of Anatomists
Gurdziel K,Vogt KR,Walton KD,Schneider GK,Gumucio DL
A-21311 was used in Immunohistochemistry to provide the first transcriptional catalog for the developing ICM and suggests that cJun regulates gene expression in the ICM downstream of Hh signaling.
Sun May 01 00:00:00 EDT 2016
Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin.
Nature communications
Fusté NP,Fernández-Hernández R,Cemeli T,Mirantes C,Pedraza N,Rafel M,Torres-Rosell J,Colomina N,Ferrezuelo F,Dolcet X,Garí E
A-21311 was used in immunocytochemistry to determine regulation of metastasis and cell invasion through the phosphorylation of paxillin due to cytoplasmic cyclin D1
Mon May 16 00:00:00 EDT 2016
EphrinB2 drives perivascular invasion and proliferation of glioblastoma stem-like cells.
eLife
Krusche B,Ottone C,Clements MP,Johnstone ER,Goetsch K,Lieven H,Mota SG,Singh P,Khadayate S,Ashraf A,Davies T,Pollard SM,De Paola V,Roncaroli F,Martinez-Torrecuadrada J,Bertone P,Parrinello S
A-21311 was used in immunocytochemistry to study the drive for proliferation and perivascular invasion of glioblastoma stem-like cells by EphrinB2
Tue Jun 28 00:00:00 EDT 2016
The cell adhesion molecule Fasciclin2 regulates brush border length and organization in Drosophila renal tubules.
Nature communications
Halberg KA,Rainey SM,Veland IR,Neuert H,Dornan AJ,Klämbt C,Davies SA,Dow JA
A-21311 was used in immunohistochemistry to characterize regulation of brush border length and organization in drosophila rena tubules by the cell adhesion molecule Fasciclin2
Wed Apr 13 00:00:00 EDT 2016
Reconstruction of genetically identified neurons imaged by serial-section electron microscopy.
eLife
Joesch M,Mankus D,Yamagata M,Shahbazi A,Schalek R,Suissa-Peleg A,Meister M,Lichtman JW,Scheirer WJ,Sanes JR
A-21311 was used in immunohistochemistry to utilize serial-section electron microscopy to visualize reconstruction of genetically identified neurons
Thu Jul 07 00:00:00 EDT 2016
Polycomb enables primitive endoderm lineage priming in embryonic stem cells.
eLife
Illingworth RS,Hölzenspies JJ,Roske FV,Bickmore WA,Brickman JM
A-21311 was used in immunocytochemistry study how polycomb alters transcription and lineage priming
Mon Oct 10 00:00:00 EDT 2016
Endothelial cells are progenitors of cardiac pericytes and vascular smooth muscle cells.
Nature communications
Chen Q,Zhang H,Liu Y,Adams S,Eilken H,Stehling M,Corada M,Dejana E,Zhou B,Adams RH
A-21311 was used in Immunohistochemistry to identify a novel and unexpected population of progenitors for coronary mural cells with relevance to heart function.
Fri Aug 12 00:00:00 EDT 2016
Hair follicle-derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma.
Nature medicine
Adachi T,Kobayashi T,Sugihara E,Yamada T,Ikuta K,Pittaluga S,Saya H,Amagai M,Nagao K
A-21311 was used in Flow cytometry/Cell sorting to implicate hair follicle-derived cytokines as regulators of malignant and non-malignant TRM cell tissue residence.
Sun Nov 01 00:00:00 EDT 2015
Neurovascular crosstalk between interneurons and capillaries is required for vision.
The Journal of clinical investigation
Usui Y,Westenskow PD,Kurihara T,Aguilar E,Sakimoto S,Paris LP,Wittgrove C,Feitelberg D,Friedlander MS,Moreno SK,Dorrell MI,Friedlander M
A-21311 was used in immunohistochemistry to study amacrine and horizontal cells in the retinal vascular plexuses.
Mon Jun 01 00:00:00 EDT 2015
Histone chaperone CAF-1 mediates repressive histone modifications to protect preimplantation mouse embryos from endogenous retrotransposons.
Proceedings of the National Academy of Sciences of the United States of America
Hatanaka Y,Inoue K,Oikawa M,Kamimura S,Ogonuki N,Kodama EN,Ohkawa Y,Tsukada Y,Ogura A
A-21311 was used in ChIP assay to protect preimplantation mouse embryos from endogenous retrotransposons by histone chaperone CAF-1 mediating repressive histone modifications
Tue Nov 24 00:00:00 EST 2015
TALPID3 controls centrosome and cell polarity and the human ortholog KIAA0586 is mutated in Joubert syndrome (JBTS23).
eLife
Stephen LA,Tawamie H,Davis GM,Tebbe L,Nürnberg P,Nürnberg G,Thiele H,Thoenes M,Boltshauser E,Uebe S,Rompel O,Reis A,Ekici AB,McTeir L,Fraser AM,Hall EA,Mill P,Daudet N,Cross C,Wolfrum U,Jamra RA,Davey MG,Bolz HJ
A-21311 was used in Immunocytochemistry to show that loss of TALPID3 (KIAA0586) function in animal models causes abnormal tissue polarity, centrosome length and orientation, and centriolar satellites.
Sat Sep 19 00:00:00 EDT 2015
LIF supports primitive endoderm expansion during pre-implantation development.
Development (Cambridge, England)
Morgani SM,Brickman JM
A-21311 was used in Immunocytochemistry to study the roles of LIF in maintaining self renewal of embryonic stem cells which express extra-embryonic markers.
Thu Oct 15 00:00:00 EDT 2015
Fibroblasts of recipient origin contribute to airway fibrosis in murine tracheal transplantations.
Transplant international : official journal of the European Society for Organ Transplantation
Konoeda C,Nakajima J,Murakawa T
A-21311 was used in immunohistochemistry - frozen section to investigate the role of recipient fibroblasts to airway fibrosis in murine model of tracheal transplantations.
Mon Jun 01 00:00:00 EDT 2015
In vitro alterations do not reflect a requirement for host cell cycle progression during Plasmodium liver stage infection.
Eukaryotic cell
Hanson KK,March S,Ng S,Bhatia SN,Mota MM
A-21311 was used in immunohistochemistry to examine the mechanism of parasite proliferation within plasmodium liver stage infection
Thu Jan 01 00:00:00 EST 2015
A Dual Role for Corneal Dendritic Cells in Herpes Simplex Keratitis: Local Suppression of Corneal Damage and Promotion of Systemic Viral Dissemination.
PloS one
Hu K,Harris DL,Yamaguchi T,von Andrian UH,Hamrah P
A-21311 was used in immunohistochemistry to study corneal dendritic cells in herpes simplex keratitis and its role in promotion of systemic viral dissemination and local suppression of corneal damage
Tue May 31 00:00:00 EDT 2016
Genetic targeting of sprouting angiogenesis using Apln-CreER.
Nature communications
Liu Q,Hu T,He L,Huang X,Tian X,Zhang H,He L,Pu W,Zhang L,Sun H,Fang J,Yu Y,Duan S,Hu C,Hui L,Zhang H,Quertermous T,Xu Q,Red-Horse K,Wythe JD,Zhou B
A-21311 was used in immunohistochemistry - frozen section to determine how ApIn-CreER can target genetically and sprout angiogenesis
Mon Jan 19 00:00:00 EST 2015
Effects of sleep and wake on astrocytes: clues from molecular and ultrastructural studies.
BMC biology
Bellesi M,de Vivo L,Tononi G,Cirelli C
A-21311 was used in immunocytochemistry to examine the effects of sleep and wake on astrocytes
Tue Aug 25 00:00:00 EDT 2015
Advanced CLARITY for rapid and high-resolution imaging of intact tissues.
Nature protocols
Tomer R,Ye L,Hsueh B,Deisseroth K
A-21311 was used in Immunohistochemistry to develop an advanced CLARITY protocol for rapid and high-resolution imaging of intact tissues.
Tue Jul 01 00:00:00 EDT 2014
Comparison of biomaterial delivery vehicles for improving acute retention of stem cells in the infarcted heart.
Biomaterials
Roche ET,Hastings CL,Lewin SA,Shvartsman D,Brudno Y,Vasilyev NV,O'Brien FJ,Walsh CJ,Duffy GP,Mooney DJ
A-21311 was used in immunohistochemistry - frozen section to assess if acute retention of cells in cardiac tissue can be improved using a biomaterial carrier
Fri Aug 01 00:00:00 EDT 2014
Deletion of the von Hippel-Lindau gene causes sympathoadrenal cell death and impairs chemoreceptor-mediated adaptation to hypoxia.
EMBO molecular medicine
Macías D,Fernández-Agüera MC,Bonilla-Henao V,López-Barneo J
A-21311 was used in Immunocytochemistry to show that Vhl deletion does not give rise to tumours but impairs development and plasticity of the peripheral oxygen-sensing system required for survival in hypoxic conditions.
Mon Dec 01 00:00:00 EST 2014
Positive feedback loop between Sox2 and Sox6 inhibits neuronal differentiation in the developing central nervous system.
Proceedings of the National Academy of Sciences of the United States of America
Lee KE,Seo J,Shin J,Ji EH,Roh J,Kim JY,Sun W,Muhr J,Lee S,Kim J
A-21311 was used in immunohistochemistry (frozen) to study the role of Sox2 activity in neural differentiation.
Tue Feb 18 00:00:00 EST 2014
A major external source of cholinergic innervation of the striatum and nucleus accumbens originates in the brainstem.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Dautan D,Huerta-Ocampo I,Witten IB,Deisseroth K,Bolam JP,Gerdjikov T,Mena-Segovia J
A-21311 was used in immunohistochemistry to show that cholinergic neurons in the brainstem provide a direct innervation of the striatal complex.
Wed Mar 26 00:00:00 EDT 2014
Murine arcuate nucleus kisspeptin neurons communicate with GnRH neurons in utero.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Kumar D,Freese M,Drexler D,Hermans-Borgmeyer I,Marquardt A,Boehm U
A-21311 was used in immunohistochemistry (frozen) to study the in utero communication between gonadotropin-releasing hormone neurons and arcuate nucleus kisspeptin neurons.
Wed Mar 05 00:00:00 EST 2014
Systematic characterization of cell cycle phase-dependent protein dynamics and pathway activities by high-content microscopy-assisted cell cycle phenotyping.
Genomics, proteomics & bioinformatics
Bruhn C,Kroll T,Wang ZQ
A-21311 was used in immunocytochemistry to develop a high-content microscopy-assisted cell cycle phenotyping method.
Mon Dec 01 00:00:00 EST 2014
A general principle governs vision-dependent dendritic patterning of retinal ganglion cells.
The Journal of comparative neurology
Xu HP,Sun JH,Tian N
A-21311 was used in immunohistochemistry to study the regulatory process for the dendritic patterning of retinal ganglion cells.
Wed Oct 15 00:00:00 EDT 2014
Dysregulation of the proteasome increases the toxicity of ALS-linked mutant SOD1.
Genes to cells : devoted to molecular & cellular mechanisms
Kitamura A,Inada N,Kubota H,Matsumoto G,Kinjo M,Morimoto RI,Nagata K
A-21311 was used in immunocytochemistry to study the biophysical properties of amyotrophic lateral sclerosis-linked mutations of Cu/Zn superoxide dismutase 1 in human cells.
Sat Mar 01 00:00:00 EST 2014
Non-destructive handling of individual chromatin fibers isolated from single cells in a microfluidic device utilizing an optically driven microtool.
Lab on a chip
Oana H,Nishikawa K,Matsuhara H,Yamamoto A,Yamamoto TG,Haraguchi T,Hiraoka Y,Washizu M
A-21311 was used in immunocytochemistry to describe a method for the non-destructive handling of individual intact chromatin fibers isolated from single cells
Fri Feb 21 00:00:00 EST 2014
Arteries are formed by vein-derived endothelial tip cells.
Nature communications
Xu C,Hasan SS,Schmidt I,Rocha SF,Pitulescu ME,Bussmann J,Meyen D,Raz E,Adams RH,Siekmann AF
A-21311 was used in immunohistochemistry to report that vein-derived endothelial tip cells contribute to emerging arteries in zebrafish
Mon Dec 15 00:00:00 EST 2014
Physiological characterization of vestibular efferent brainstem neurons using a transgenic mouse model.
PloS one
Leijon S,Magnusson AK
A-21311 was used in immunohistochemistry to elucidate the functional role of efferent innervation of the vestibular end-organs in the inner ear
Thu Aug 13 00:00:00 EDT 2015
The effect of photoreceptor degeneration on ganglion cell morphology.
The Journal of comparative neurology
O'Brien EE,Greferath U,Fletcher EL
A-21311 was used in Immunohistochemistry-wholemount to investigated in detail whether ganglion cells are altered at late stages of degeneration, well after the total loss of photoreceptors.
Tue Apr 01 00:00:00 EDT 2014
Sustained IL-1β expression impairs adult hippocampal neurogenesis independent of IL-1 signaling in nestin+ neural precursor cells.
Brain, behavior, and immunity
Wu MD,Montgomery SL,Rivera-Escalera F,Olschowka JA,O'Banion MK
A-21311 was used in immunohistochemistry - free floating to elucidate the role of IL-β during neurogenesis.
Thu Aug 01 00:00:00 EDT 2013
Notch controls retinal blood vessel maturation and quiescence.
Development (Cambridge, England)
Ehling M,Adams S,Benedito R,Adams RH
A-21311 was used in immunohistochemistry - frozen section to investigate the contribution of endothelial Notch signaling to vessel remodeling and maturation
Mon Jul 01 00:00:00 EDT 2013
Neurons with GABAergic phenotype in the visual system of Drosophila.
The Journal of comparative neurology
Raghu SV,Claussen J,Borst A
A-21311 was used in immunohistochemistry to identify neurons in the Drosophila optic lobes that release gamma aminobutyric acid.
Tue Jan 01 00:00:00 EST 2013
Unusual features in four canine meningiomas.
Journal of comparative pathology
Schöniger S,Woolford L,Jutras L,Head E,de Lahunta A,Summers BA
A-21311 was used in Immunohistochemistry to describe four canine meningiomas with previously unreported features.
Fri Mar 14 00:00:00 EDT 2014
Neuropilin2 regulates the guidance of post-crossing spinal commissural axons in a subtype-specific manner.
Neural development
Tran TS,Carlin E,Lin R,Martinez E,Johnson JE,Kaprielian Z
A-21311 was used in immunohistochemistry to study the role of neurophilin2 and its regulation of post-crossing spinal commissural axons in a subtype-specific manner
Wed Jul 31 00:00:00 EDT 2013
Expression of trefoil factor genes in the duodenum and colon of dogs with inflammatory bowel disease and healthy dogs.
Veterinary immunology and immunopathology
Schmitz S,Hill S,Werling D,Allenspach K
A-21311 was used in Immunohistochemistry-immunofluorescence to demonstrate evidence for dysregulation of TFF gene expression in canine IBD.
Tue Jan 15 00:00:00 EST 2013
Exercise affects joint injury risk in young Thoroughbreds in training.
Veterinary journal (London, England : 1997)
Reed SR,Jackson BF,Wood JL,Price JS,Verheyen KL
A-21311 was used in Immunohistochemistry-immunofluorescence to suggest that regular canter exercise is generally beneficial for joint health, while accumulation of high-speed exercise detrimentally affects MCP/MTP joints.
Sat Jun 01 00:00:00 EDT 2013
Chromosome movements promoted by the mitochondrial protein SPD-3 are required for homology search during Caenorhabditis elegans meiosis.
PLoS genetics
Labrador L,Barroso C,Lightfoot J,Müller-Reichert T,Flibotte S,Taylor J,Moerman DG,Villeneuve AM,Martinez-Perez E
A-21311 was used in immunohistochemistry - paraffin section to investigate how chromosome mobility impacts different early meiotic events that promote homolog pairing.
Wed May 01 00:00:00 EDT 2013
European veterinary public health specialization: post-graduate training and expectations of potential employers.
Journal of veterinary medical education
Alonso S,Dürr S,Fahrion A,Harisberger M,Papadopoulou C,Zimmerli U
A-21311 was used in Immunohistochemistry to provide input for a critical revision of the European College of Veterinary Public Health (ECVPH) curriculum and the design of post-graduate training programs in veterinary public health (VPH).
Thu Jun 13 00:00:00 EDT 2013
Isolation of primitive endoderm, mesoderm, vascular endothelial and trophoblast progenitors from human pluripotent stem cells.
Nature biotechnology
Drukker M,Tang C,Ardehali R,Rinkevich Y,Seita J,Lee AS,Mosley AR,Weissman IL,Soen Y
A-21311 was used in immunocytochemistry to identify early populations of committed progenitors derived from human embryonic stem cells.
Sun May 27 00:00:00 EDT 2012
Electrical coupling and propagation in engineered ventricular myocardium with heterogeneous expression of connexin43.
Circulation research
Beauchamp P,Desplantez T,McCain ML,Li W,Asimaki A,Rigoli G,Parker KK,Saffitz JE,Kleber AG
A-21311 was used in immunohistochemistry to study connexin expression in arrhythmogenesis.
Fri May 25 00:00:00 EDT 2012
Gut endoderm is involved in the transfer of left-right asymmetry from the node to the lateral plate mesoderm in the mouse embryo.
Development (Cambridge, England)
Saund RS,Kanai-Azuma M,Kanai Y,Kim I,Lucero MT,Saijoh Y
A-21311 was used in immunohistochemistry to assess the role of the endoderm in establishing the left-right axis.
Sun Jul 01 00:00:00 EDT 2012
In vivo Notch reactivation in differentiating cochlear hair cells induces Sox2 and Prox1 expression but does not disrupt hair cell maturation.
Developmental dynamics : an official publication of the American Association of Anatomists
Liu Z,Owen T,Fang J,Srinivasan RS,Zuo J
A-21311 was used in immunohistochemistry to test if NICD reactivation in differentiating hair cells interrupts their developmental program and reactivates downstream targets.
Sun Apr 01 00:00:00 EDT 2012
Columnar cells necessary for motion responses of wide-field visual interneurons in Drosophila.
Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology
Schnell B,Raghu SV,Nern A,Borst A
A-21311 was used in immunohistochemistry to elucidate the neurons involved in sensing motion using fruit flies.
Tue May 01 00:00:00 EDT 2012
Overactivation of Notch1 signaling induces ectopic hair cells in the mouse inner ear in an age-dependent manner.
PloS one
Liu Z,Owen T,Fang J,Zuo J
A-21311 was used in immunocytochemistry to determine if reactivation of Notch signaling can stimulate hair cells development.
Mon Aug 20 00:00:00 EDT 2012
Dopamine D2 receptor activity modulates Akt signaling and alters GABAergic neuron development and motor behavior in zebrafish larvae.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Souza BR,Romano-Silva MA,Tropepe V
A-21311 was used in immunohistochemistry to use a zebrafish model to examine the impact of altered dopamine signaling on brain development and larval motor behavior.
Wed Apr 06 00:00:00 EDT 2011
Colocalization of hyperpolarization-activated, cyclic nucleotide-gated channel subunits in rat retinal ganglion cells.
The Journal of comparative neurology
Stradleigh TW,Ogata G,Partida GJ,Oi H,Greenberg KP,Krempely KS,Ishida AT
A-21311 was used in immunohistochemistry to investigate cyclic nucleotide-gated channel subunits in rat retinal ganglion cells.
Thu Sep 01 00:00:00 EDT 2011
Candidate glutamatergic neurons in the visual system of Drosophila.
PloS one
Raghu SV,Borst A
A-21311 was used in immunohistochemistry to identify glutamatergic neurons of the fly visual system.
Thu May 05 00:00:00 EDT 2011
Role of afferents in the differentiation of bipolar cells in the mouse retina.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Keeley PW,Reese BE
A-21311 was used in immunohistochemistry to study the role of photoreceptors in directing the differentiation of bipolar cells
Wed Feb 03 00:00:00 EST 2010
Processing of horizontal optic flow in three visual interneurons of the Drosophila brain.
Journal of neurophysiology
Schnell B,Joesch M,Forstner F,Raghu SV,Otsuna H,Ito K,Borst A,Reiff DF
A-21311 was used in immunohistochemistry to identify neurons involved in optomotor behavior in fruit flies
Mon Mar 01 00:00:00 EST 2010
Inducible gene targeting in the neonatal vasculature and analysis of retinal angiogenesis in mice.
Nature protocols
Pitulescu ME,Schmidt I,Benedito R,Adams RH
A-21311 was used in immunohistochemistry - paraffin section to describe protocols for tamoxifen-inducible gene deletion of neonatal mice, retina dissection, whole-mount immunostaining. and the quantitation of endothelial cell sprouting and proliferation
Wed Sep 01 00:00:00 EDT 2010
High-efficiency transient transduction of human embryonic stem cell-derived neurons with baculoviral vectors.
Molecular therapy : the journal of the American Society of Gene Therapy
Zeng J,Du J,Lin J,Bak XY,Wu C,Wang S
A-21311 was used in immunocytochemistry to generate a set of baculoviral vectors for transient transduction of nondividing neurons
Tue Sep 01 00:00:00 EDT 2009
Synaptic organization of lobula plate tangential cells in Drosophila: Dalpha7 cholinergic receptors.
Journal of neurogenetics
Raghu SV,Joesch M,Sigrist SJ,Borst A,Reiff DF
A-21311 was used in immunohistochemistry to examine the subcellular distribution of nicotinic acetylcholine receptors in lobula plate tangential cells
Mon Jan 11 00:00:00 EST 2010
MECP2 isoform-specific vectors with regulated expression for Rett syndrome gene therapy.
PloS one
Rastegar M,Hotta A,Pasceri P,Makarem M,Cheung AY,Elliott S,Park KJ,Adachi M,Jones FS,Clarke ID,Dirks P,Ellis J
A-21311 was used in flow cytometry to develop viral vectors to treat patients with Rett Syndrome
Thu Aug 27 00:00:00 EDT 2009
Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Damiani D,Alexander JJ,O'Rourke JR,McManus M,Jadhav AP,Cepko CL,Hauswirth WW,Harfe BD,Strettoi E
A-21311 was used in immunohistochemistry to study the structural and progressive functional degeneration of the mouse retina due to dicer inactivation
Wed May 07 00:00:00 EDT 2008
Dendrite remodeling and other abnormalities in the retinal ganglion cells of Ins2 Akita diabetic mice.
Investigative ophthalmology & visual science
Gastinger MJ,Kunselman AR,Conboy EE,Bronson SK,Barber AJ
A-21311 was used in Immunohistochemistry to show that retinal ganglion cells are lost from the peripheral retina of mice within the first 3 months of diabetes and that the dendrites of surviving large ON-type cells undergo morphologic changes.
Sun Jun 01 00:00:00 EDT 2008
Glycine receptor-mediated synaptic transmission regulates the maturation of ganglion cell synaptic connectivity.
The Journal of comparative neurology
Xu HP,Tian N
A-21311 was used in immunohistochemistry to investigate the role of glycine receptor-mediated synaptic transmission in the maturation of ganglion cell synaptic connectivity.
Tue Jul 01 00:00:00 EDT 2008
Benign peripheral nerve sheath tumor of the perianal region in a young pony.
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
Sturgeon BP,Milne EM,Smith KC
A-21311 was used in Immunohistochemistry-immunofluorescence to uncover a benign peripheral nerve sheath tumor (schwannoma type) in the perianal region of a 4-year-old Dales pony.
Tue Jan 01 00:00:00 EST 2008
Ablation of leptin signaling disrupts the establishment, development, and maintenance of endometriosis-like lesions in a murine model.
Endocrinology
Styer AK,Sullivan BT,Puder M,Arsenault D,Petrozza JC,Serikawa T,Chang S,Hasan T,Gonzalez RR,Rueda BR
A-21311 was used in Immunohistochemistry-immunofluorescence to show that the disruption of leptin signaling by ip injection of the pegylated leptin peptide receptor antagonist (LPrA) impairs the establishment of endometriosis-like lesions (derived from uteri of C57BL/6 female siblings) and results in a reduction of viable organized glandular epithelium, vascular endothelial growth factor-A expression, and mitotic activity.
Fri Feb 01 00:00:00 EST 2008
In vivo imaging of germinal centres reveals a dynamic open structure.
Nature
Schwickert TA,Lindquist RL,Shakhar G,Livshits G,Skokos D,Kosco-Vilbois MH,Dustin ML,Nussenzweig MC
A-21311 was used in immunohistochemistry - frozen section to visualize B cells in lymph node germinal centers in vivo
Thu Mar 01 00:00:00 EST 2007
Regulatory T cell development in the absence of functional Foxp3.
Nature immunology
Lin W,Haribhai D,Relland LM,Truong N,Carlson MR,Williams CB,Chatila TA
A-21311 was used in immunohistochemistry to elucidate the function of Foxp3 in T regulatory cell lineage commitment
Sun Apr 01 00:00:00 EDT 2007
Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1.
Proceedings of the National Academy of Sciences of the United States of America
Jang HJ,Kokrashvili Z,Theodorakis MJ,Carlson OD,Kim BJ,Zhou J,Kim HH,Xu X,Chan SL,Juhaszova M,Bernier M,Mosinger B,Margolskee RF,Egan JM
A-21311 was used in immunohistochemistry - paraffin section to investigate how intestinal L cells sense glucose.
Tue Sep 18 00:00:00 EDT 2007
Gene replacement reveals a specific role for E-cadherin in the formation of a functional trophectoderm.
Development (Cambridge, England)
Kan NG,Stemmler MP,Junghans D,Kanzler B,de Vries WN,Dominis M,Kemler R
A-21311 was used in immunohistochemistry - paraffin section to elucidate the contribution of E-cadherin to trophectoderm formation in vivo.
Mon Jan 01 00:00:00 EST 2007
pygopus 2 has a crucial, Wnt pathway-independent function in lens induction.
Development (Cambridge, England)
Song N,Schwab KR,Patterson LT,Yamaguchi T,Lin X,Potter SS,Lang RA
A-21311 was used in Immunohistochemistry to provide multiple lines of evidence that although Pygo2 can function in the Wnt pathway, its activity in lens development is Wnt pathway-independent.
Tue May 01 00:00:00 EDT 2007
Drosophila huntingtin-interacting protein 14 is a presynaptic protein required for photoreceptor synaptic transmission and expression of the palmitoylated proteins synaptosome-associated protein 25 and cysteine string protein.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Stowers RS,Isacoff EY
A-21311 was used in immunohistochemistry - frozen section to characterize a dHIP14 mutant in Drosophila
Wed Nov 21 00:00:00 EST 2007
Baculoviral vector-mediated transient and stable transgene expression in human embryonic stem cells.
Stem cells (Dayton, Ohio)
Zeng J,Du J,Zhao Y,Palanisamy N,Wang S
A-21311 was used in immunocytochemistry to use baculoviral vectors to transduce human embryonic stem cells
Sun Apr 01 00:00:00 EDT 2007
Mechanisms controlling Pax6 isoform expression in the retina have been conserved between teleosts and mammals.
Developmental biology
Lakowski J,Majumder A,Lauderdale JD
A-21311 was used in immunohistochemistry - frozen section to examine the spatiotemporal expression of Pax6 isoforms in the vertebrate retina
Sun Jul 15 00:00:00 EDT 2007
Synaptic organization of lobula plate tangential cells in Drosophila: gamma-aminobutyric acid receptors and chemical release sites.
The Journal of comparative neurology
Raghu SV,Joesch M,Borst A,Reiff DF
A-21311 was used in immunohistochemistry to examine the distribution of presynaptic release and postsynaptic inhibitory sites in the large tangential cells of Drosophila melanogaster.
Fri Jun 01 00:00:00 EDT 2007
Alopecia in pomeranians and miniature poodles in association with high urinary corticoid:creatinine ratios and resistance to glucocorticoid feedback.
The Veterinary record
Cerundolo R,Lloyd DH,Vaessen MM,Mol JA,Kooistra HS,Rijnberk A
A-21311 was used in Immunohistochemistry-immunofluorescence to detect, in an oral high-dose dexamethasone suppression test, using 0.1 mg dexamethasone/kg bodyweight, the uccrs of seven alopecic pomeranians and five alopecic miniature poodles decreased to low levels.
Sat Mar 24 00:00:00 EDT 2007
Causative organisms and somatic cell counts in subclinical intramammary infections in milking goats in the UK.
The Veterinary record
Hall SM,Rycroft AN
A-21311 was used in Immunohistochemistry-immunofluorescence to determine the bacterial causes of subclinical mastitisin samples of milk taken from one half of the udders of 159 goats in three different herds.
Sat Jan 06 00:00:00 EST 2007
A putative Src homology 3 domain binding motif but not the C-terminal dystrophin WW domain binding motif is required for dystroglycan function in cellular polarity in Drosophila.
The Journal of biological chemistry
Yatsenko AS,Gray EE,Shcherbata HR,Patterson LB,Sood VD,Kucherenko MM,Baker D,Ruohola-Baker H
A-21311 was used in immunohistochemistry to study the requirement for dystroglycan function in cellular polarity in Drosophila by a putative Src homology 3 domain binding motif by not the C-terminal dystrophin WW domain binding motif
Fri May 18 00:00:00 EDT 2007
Changes in the glomerular filtration rate of 27 cats with hyperthyroidism after treatment with radioactive iodine.
The Veterinary record
Boag AK,Neiger R,Slater L,Stevens KB,Haller M,Church DB
A-21311 was used in Immunohistochemistry-immunofluorescence to describes the changes in the gfr of 27 hyperthyroid cats in the six months after their treatment with radioactive iodine ((131)I) and evaluate whether any commonly measured pretreatment parameters could predict a clinically significant decline in renal function.
Sat Nov 24 00:00:00 EST 2007
Doublecortin-like kinase controls neurogenesis by regulating mitotic spindles and M phase progression.
Neuron
Shu T,Tseng HC,Sapir T,Stern P,Zhou Y,Sanada K,Fischer A,Coquelle FM,Reiner O,Tsai LH
A-21311 was used in immunohistochemistry to suggest that DCLK regulates the fate of neural progenitors during cortical neurogenesis
Thu Jan 05 00:00:00 EST 2006
Delayed development of adult-generated granule cells in dentate gyrus.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Overstreet-Wadiche LS,Bensen AL,Westbrook GL
A-21311 was used in immunohistochemistry - free floating to study adult-generated granule cells in dentate gyrus and delayed development
Wed Feb 22 00:00:00 EST 2006
Seizures accelerate functional integration of adult-generated granule cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Overstreet-Wadiche LS,Bromberg DA,Bensen AL,Westbrook GL
A-21311 was used in immunohistochemistry to study acceleration of functional integration of adult-generated granule cells due to seizures
Wed Apr 12 00:00:00 EDT 2006
Postnatal cellular contributions of the hippocampus subventricular zone to the dentate gyrus, corpus callosum, fimbria, and cerebral cortex.
The Journal of comparative neurology
Navarro-Quiroga I,Hernandez-Valdes M,Lin SL,Naegele JR
A-21311 was used in immunohistochemistry to study the role of hippocampus subventricular zone progenitors in the development of dentate gyrus, corpus callosum, fimbria, and cerebral cortex
Thu Aug 10 00:00:00 EDT 2006
Total and relative deficiency of gut mucosal IgA in German shepherd dogs demonstrated by faecal analysis.
The Veterinary record
Littler RM,Batt RM,Lloyd DH
A-21311 was used in Immunocytochemistry, Immunohistochemistry, Western Blot, Sample Prep to investigate the concentration of immunoglobulins in faecal extracts, as a method of assessing the production of immunoglobulins by the gut mucosa of 137 dogs.
Sat Mar 11 00:00:00 EST 2006
Treatment of periocular and non-ocular sarcoids in 18 horses by interstitial brachytherapy with iridium-192.
The Veterinary record
Byam-Cook KL,Henson FM,Slater JD
A-21311 was used in Immunohistochemistry-immunofluorescence to review the efficacy of iridium-192 interstitial brachytherapy for the treatment of eight periocular sarcoids and 15 non-ocular sarcoids on 18 horses.
Sat Sep 09 00:00:00 EDT 2006
Critical variables in the conversion of marrow cells to skeletal muscle.
Blood
Abedi M,Greer DA,Foster BM,Colvin GA,Harpel JA,Demers DA,Pimentel J,Dooner MS,Quesenberry PJ
A-21311 was used in immunocytochemistry to characterize the conversion of marrow cells to skeletal muscle and critical variables
Mon Aug 15 00:00:00 EDT 2005
Receptor tyrosine phosphatase-dependent cytoskeletal remodeling by the hedgehog-responsive gene MIM/BEG4.
The Journal of cell biology
Gonzalez-Quevedo R,Shoffer M,Horng L,Oro AE
A-21311 was used in immunocytochemistry to propose that Missing in Metastasis cooperates with receptor protein tyrosine phosphatases to induce cytoskeletal changes
Mon Jan 31 00:00:00 EST 2005
Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity.
The Journal of cell biology
Bennett CL,van Rijn E,Jung S,Inaba K,Steinman RM,Kapsenberg ML,Clausen BE
A-21311 was used in immunohistochemistry to develop Langerin-DTR mice to study Langerhans cells
Mon May 23 00:00:00 EDT 2005
In vivo characterization of bone marrow-derived fibroblasts recruited into fibrotic lesions.
Stem cells (Dayton, Ohio)
Ishii G,Sangai T,Sugiyama K,Ito T,Hasebe T,Endoh Y,Magae J,Ochiai A
A-21311 was used in immunohistochemistry - paraffin section to study the recruitment into fibrotic lesions by in vivo characterization of bone marrow-derived fibroblasts
Sun May 01 00:00:00 EDT 2005
Effects of RNA interference of Trypanosoma brucei structure-specific endonuclease-I on kinetoplast DNA replication.
The Journal of biological chemistry
Liu Y,Motyka SA,Englund PT
A-21311 was used in immunocytochemistry to characterize the structure-specific endonuclease-I homolog from Trypanosoma brucei
Fri Oct 21 00:00:00 EDT 2005
Eotaxin-1-regulated eosinophils have a critical role in innate immunity against experimental Brugia malayi infection.
European journal of immunology
Simons JE,Rothenberg ME,Lawrence RA
A-21311 was used in Immunocytochemistry, Immunohistochemistry, Western Blot, Sample Prep to show that the presence of eosinophils is critical for innate clearance of B. malayi Mf infection, whereas rapid clearance of secondary infections is independent of both eotaxin-1 and IL-5.
Sat Jan 01 00:00:00 EST 2005
Eotaxin-1-regulated eosinophils have a critical role in innate immunity against experimental Brugia malayi infection.
European journal of immunology
Simons JE,Rothenberg ME,Lawrence RA
A-21311 was used in Immunocytochemistry, Immunohistochemistry, Western Blot, Sample Prep to show that the presence of eosinophils is critical for innate clearance of B. malayi Mf infection, whereas rapid clearance of secondary infections is independent of both eotaxin-1 and IL-5.
Sat Jan 01 00:00:00 EST 2005
Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium.
Nature
Balsam LB,Wagers AJ,Christensen JL,Kofidis T,Weissman IL,Robbins RC
A-21311 was used in immunohistochemistry - frozen section to analyze the adoption of mature haematopoietic fates in ischaemic myocardium by haematopoietic stem cells
Thu Apr 08 00:00:00 EDT 2004
GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain.
Nature neuroscience
Garcia AD,Doan NB,Imura T,Bush TG,Sofroniew MV
A-21311 was used in immunohistochemistry - frozen section to use transgenic mice to identify adult multipotent neural progenitors in vivo
Mon Nov 01 00:00:00 EST 2004
Shifting foci of hematopoiesis during reconstitution from single stem cells.
Proceedings of the National Academy of Sciences of the United States of America
Cao YA,Wagers AJ,Beilhack A,Dusich J,Bachmann MH,Negrin RS,Weissman IL,Contag CH
A-21311 was used in immunohistochemistry - frozen section to study reconstitution from single stem cells by shifting foci of hematopoiesis
Tue Jan 06 00:00:00 EST 2004
Keratins modulate c-Flip/extracellular signal-regulated kinase 1 and 2 antiapoptotic signaling in simple epithelial cells.
Molecular and cellular biology
Gilbert S,Loranger A,Marceau N
A-21311 was used in immunocytochemistry to study the role of keratins in modulating cFlip and ERK1/2 apoptotic signaling in epithelial cells
Sun Aug 01 00:00:00 EDT 2004
Improvement of combined FISH and immunofluorescence to trace the fate of somatic stem cells after transplantation.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Donadoni C,Corti S,Locatelli F,Papadimitriou D,Guglieri M,Strazzer S,Bossolasco P,Salani S,Comi GP
A-21311 was used in immunohistochemistry - frozen section to study the trace of the fate of somatic stem cells after transplantation due to improvement of combined immunofluorescence and FISH
Fri Oct 01 00:00:00 EDT 2004
Quantitative gene expression analysis reveals transition of fetal liver progenitor cells to mature hepatocytes after transplantation in uPA/RAG-2 mice.
The American journal of pathology
Cantz T,Zuckerman DM,Burda MR,Dandri M,Göricke B,Thalhammer S,Heckl WM,Manns MP,Petersen J,Ott M
A-21311 was used in immunohistochemistry - frozen section to apply quantitative gene expression methods to analyze the differentiation process of fetal liver progenitor cells after transplantation into an animal model of liver regeneration.
Wed Jan 01 00:00:00 EST 2003
Subzonal organization of olfactory sensory neurons projecting to distinct glomeruli within the mouse olfactory bulb.
The Journal of comparative neurology
Levai O,Breer H,Strotmann J
A-21311 was used in immunohistochemistry to label olfactory sensory neurons within distinct areas of the olfactory epithelium
Mon Apr 07 00:00:00 EDT 2003
What is your diagnosis? Thoracic trauma.
The Journal of small animal practice
Dorey S,Maitra AS,Lamb CR
A-21311 was used in Immunohistochemistry-immunofluorescence to conclude that the Prrx1eGFP mouse is a powerful tool to visualize and isolate periosteal cells and to quantify their properties in the embryo and adult.
Fri Sep 01 00:00:00 EDT 2000
Planimetric evaluation and comparison of roentgenograms of osteogenic sarcomas induced by 226Ra and 224Ra in mice.
Neoplasma
Svoboda V,Kofránek V,Kotasková Z,Bubeniková D,Dvorák V
Thu Oct 20 00:00:00 EDT 1977
