Product References
Small-molecule inhibitors that disrupt the MTDH-SND1 complex suppress breast cancer progression and metastasis.
Nature cancer
Shen M,Wei Y,Kim H,Wan L,Jiang YZ,Hang X,Raba M,Remiszewski S,Rowicki M,Wu CG,Wu S,Zhang L,Lu X,Yuan M,Smith HA,Zheng A,Bertino J,Jin JF,Xing Y,Shao ZM,Kang Y
40-6500 was used in Immunoprecipitation to demonstrate a significant therapeutic potential in targeting the MTDH-SND1 complex and identify a new class of therapeutic agents for metastatic breast cancer.
Sat Jan 01 00:00:00 EST 2022
Pharmacological disruption of the MTDH-SND1 complex enhances tumor antigen presentation and synergizes with anti-PD-1 therapy in metastatic breast cancer.
Nature cancer
Shen M,Smith HA,Wei Y,Jiang YZ,Zhao S,Wang N,Rowicki M,Tang Y,Hang X,Wu S,Wan L,Shao ZM,Kang Y
40-6500 was used in RNA Immunoprecipitation, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to reveal a key role for this complex in suppressing antitumor T cell responses in breast cancer.
Sat Jan 01 00:00:00 EST 2022
Disruption of SND1-MTDH Interaction by a High Affinity Peptide Results in SND1 Degradation and Cytotoxicity to Breast Cancer Cells In Vitro and In Vivo.
Molecular cancer therapeutics
Li P,He Y,Chen T,Choy KY,Chow TS,Wong ILK,Yang X,Sun W,Su X,Chan TH,Chow LMC
40-6500 was used in Immunoprecipitation, Western Blot to study the disruption of Staphylococcal nuclease domain-containing protein 1 (SND1)-metadherin (MTDH) interaction.
Fri Jan 01 00:00:00 EST 2021
Disruption of SND1-MTDH Interaction by a High Affinity Peptide Results in SND1 Degradation and Cytotoxicity to Breast Cancer Cells In Vitro and In Vivo.
Molecular cancer therapeutics
Li P,He Y,Chen T,Choy KY,Chow TS,Wong ILK,Yang X,Sun W,Su X,Chan TH,Chow LMC
40-6500 was used in Immunoprecipitation, Western Blot to study the disruption of Staphylococcal nuclease domain-containing protein 1 (SND1)-metadherin (MTDH) interaction.
Fri Jan 01 00:00:00 EST 2021
AEG-1 Regulates TWIK-1 Expression as an RNA-Binding Protein in Astrocytes.
Brain sciences
Jung HG,Kim A,Kim SC,Park JY,Hwang EM
40-6500 was used in Western Blot, Immunocytochemistry to investigate proteins directly regulated by AEG-1 by analyzing their RNA expression patterns in astrocytes transfected with scramble shRNA and AEG-1 shRNA.
Mon Jan 11 00:00:00 EST 2021
AEG-1 Regulates TWIK-1 Expression as an RNA-Binding Protein in Astrocytes.
Brain sciences
Jung HG,Kim A,Kim SC,Park JY,Hwang EM
40-6500 was used in Western Blot, Immunocytochemistry to investigate proteins directly regulated by AEG-1 by analyzing their RNA expression patterns in astrocytes transfected with scramble shRNA and AEG-1 shRNA.
Mon Jan 11 00:00:00 EST 2021
AEG-1 Regulates TWIK-1 Expression as an RNA-Binding Protein in Astrocytes.
Brain sciences
Jung HG,Kim A,Kim SC,Park JY,Hwang EM
40-6500 was used in Western Blot, Immunocytochemistry to investigate proteins directly regulated by AEG-1 by analyzing their RNA expression patterns in astrocytes transfected with scramble shRNA and AEG-1 shRNA.
Mon Jan 11 00:00:00 EST 2021
AEG-1 Regulates TWIK-1 Expression as an RNA-Binding Protein in Astrocytes.
Brain sciences
Jung HG,Kim A,Kim SC,Park JY,Hwang EM
40-6500 was used in Western Blot, Immunocytochemistry to investigate proteins directly regulated by AEG-1 by analyzing their RNA expression patterns in astrocytes transfected with scramble shRNA and AEG-1 shRNA.
Mon Jan 11 00:00:00 EST 2021
MTDH/AEG-1 downregulation using pristimerin-loaded nanoparticles inhibits Fanconi anemia proteins and increases sensitivity to platinum-based chemotherapy.
Gynecologic oncology
Bi J,Areecheewakul S,Li Y,Yang S,Zhang Y,Ebeid K,Li L,Thiel KW,Zhang J,Dai D,Salem AK,Leslie KK,Meng X
40-6500 was used in Western Blotting to discover that treatment with pristimerin in a novel nanoparticle formulation markedly inhibited tumor growth when combined with cisplatin.
Fri Nov 01 00:00:00 EDT 2019
Role of metadherin in estrogen-regulated gene expression.
International journal of molecular medicine
Li Y,Gonzalez Bosquet J,Yang S,Thiel KW,Zhang Y,Liu H,Leslie KK,Meng X
Published figure using Metadherin polyclonal antibody (Product # 40-6500) in Western Blot
Tue Aug 01 00:00:00 EDT 2017
Role of metadherin in estrogen-regulated gene expression.
International journal of molecular medicine
Li Y,Gonzalez Bosquet J,Yang S,Thiel KW,Zhang Y,Liu H,Leslie KK,Meng X
Published figure using Metadherin polyclonal antibody (Product # 40-6500) in Western Blot
Tue Aug 01 00:00:00 EDT 2017
Astrocyte Elevated Gene 1 Interacts with Acetyltransferase p300 and c-Jun To Promote Tumor Aggressiveness.
Molecular and cellular biology
Liu L,Guan H,Li Y,Ying Z,Wu J,Zhu X,Song L,Li J,Li M
406500 was used in ChIP assay, immunoprecipitation, and western blot to discuss how c-jun regulates astrocyte elevated gene-1 in gliomas
Wed Mar 01 00:00:00 EST 2017
Astrocyte Elevated Gene 1 Interacts with Acetyltransferase p300 and c-Jun To Promote Tumor Aggressiveness.
Molecular and cellular biology
Liu L,Guan H,Li Y,Ying Z,Wu J,Zhu X,Song L,Li J,Li M
406500 was used in ChIP assay, immunoprecipitation, and western blot to discuss how c-jun regulates astrocyte elevated gene-1 in gliomas
Wed Mar 01 00:00:00 EST 2017
Metadherin promotes metastasis by supporting putative cancer stem cell properties and epithelial plasticity in pancreatic cancer.
Oncotarget
Suzuki K,Takano S,Yoshitomi H,Nishino H,Kagawa S,Shimizu H,Furukawa K,Miyazaki M,Ohtsuka M
Published figure using Metadherin polyclonal antibody (Product # 40-6500) in Immunofluorescence
Tue Sep 12 00:00:00 EDT 2017
Metadherin promotes metastasis by supporting putative cancer stem cell properties and epithelial plasticity in pancreatic cancer.
Oncotarget
Suzuki K,Takano S,Yoshitomi H,Nishino H,Kagawa S,Shimizu H,Furukawa K,Miyazaki M,Ohtsuka M
Published figure using Metadherin polyclonal antibody (Product # 40-6500) in Immunofluorescence
Tue Sep 12 00:00:00 EDT 2017
Metadherin promotes metastasis by supporting putative cancer stem cell properties and epithelial plasticity in pancreatic cancer.
Oncotarget
Suzuki K,Takano S,Yoshitomi H,Nishino H,Kagawa S,Shimizu H,Furukawa K,Miyazaki M,Ohtsuka M
Published figure using Metadherin polyclonal antibody (Product # 40-6500) in Immunofluorescence
Tue Sep 12 00:00:00 EDT 2017
Overexpression of miR-506 suppresses proliferation and promotes apoptosis of osteosarcoma cells by targeting astrocyte elevated gene-1.
Oncology letters
Yao J,Qin L,Miao S,Wang X,Wu X
40-6500 was used in western blot determine the role of miR-506 in osteosarcoma pathogenesis
Thu Sep 01 00:00:00 EDT 2016
Metadherin contributes to the pathogenesis of chronic lymphocytic leukemia partially through Wnt/β-catenin pathway.
Medical oncology (Northwood, London, England)
Li PP,Feng LL,Chen N,Ge XL,Lv X,Lu K,Ding M,Yuan D,Wang X
40-6500 was used in western blot to investigate metadherin expression, significance, and related mechanism in chronic lymphocytic leukemia
Sun Feb 01 00:00:00 EST 2015
Genetic Deficiency of Mtdh Gene in Mice Causes Male Infertility via Impaired Spermatogenesis and Alterations in the Expression of Small Non-coding RNAs.
The Journal of biological chemistry
Meng X,Yang S,Zhang Y,Wang X,Goodfellow RX,Jia Y,Thiel KW,Reyes HD,Yang B,Leslie KK
Published figure using Metadherin polyclonal antibody (Product # 40-6500) in Immunohistochemistry
Fri May 08 00:00:00 EDT 2015
Genetic Deficiency of Mtdh Gene in Mice Causes Male Infertility via Impaired Spermatogenesis and Alterations in the Expression of Small Non-coding RNAs.
The Journal of biological chemistry
Meng X,Yang S,Zhang Y,Wang X,Goodfellow RX,Jia Y,Thiel KW,Reyes HD,Yang B,Leslie KK
Published figure using Metadherin polyclonal antibody (Product # 40-6500) in Immunohistochemistry
Fri May 08 00:00:00 EDT 2015
Genetic Deficiency of Mtdh Gene in Mice Causes Male Infertility via Impaired Spermatogenesis and Alterations in the Expression of Small Non-coding RNAs.
The Journal of biological chemistry
Meng X,Yang S,Zhang Y,Wang X,Goodfellow RX,Jia Y,Thiel KW,Reyes HD,Yang B,Leslie KK
Published figure using Metadherin polyclonal antibody (Product # 40-6500) in Immunohistochemistry
Fri May 08 00:00:00 EDT 2015
MTDH-SND1 interaction is crucial for expansion and activity of tumor-initiating cells in diverse oncogene- and carcinogen-induced mammary tumors.
Cancer cell
Wan L,Lu X,Yuan S,Wei Y,Guo F,Shen M,Yuan M,Chakrabarti R,Hua Y,Smith HA,Blanco MA,Chekmareva M,Wu H,Bronson RT,Haffty BG,Xing Y,Kang Y
Published figure using Metadherin polyclonal antibody (Product # 40-6500) in Immunoprecipitation
Mon Jul 14 00:00:00 EDT 2014
MTDH-SND1 interaction is crucial for expansion and activity of tumor-initiating cells in diverse oncogene- and carcinogen-induced mammary tumors.
Cancer cell
Wan L,Lu X,Yuan S,Wei Y,Guo F,Shen M,Yuan M,Chakrabarti R,Hua Y,Smith HA,Blanco MA,Chekmareva M,Wu H,Bronson RT,Haffty BG,Xing Y,Kang Y
Published figure using Metadherin polyclonal antibody (Product # 40-6500) in Immunoprecipitation
Mon Jul 14 00:00:00 EDT 2014
MTDH-SND1 interaction is crucial for expansion and activity of tumor-initiating cells in diverse oncogene- and carcinogen-induced mammary tumors.
Cancer cell
Wan L,Lu X,Yuan S,Wei Y,Guo F,Shen M,Yuan M,Chakrabarti R,Hua Y,Smith HA,Blanco MA,Chekmareva M,Wu H,Bronson RT,Haffty BG,Xing Y,Kang Y
Published figure using Metadherin polyclonal antibody (Product # 40-6500) in Immunoprecipitation
Mon Jul 14 00:00:00 EDT 2014
Genetic ablation of metadherin inhibits autochthonous prostate cancer progression and metastasis.
Cancer research
Wan L,Hu G,Wei Y,Yuan M,Bronson RT,Yang Q,Siddiqui J,Pienta KJ,Kang Y
Published figure using Metadherin polyclonal antibody (Product # 40-6500) in Immunohistochemistry
Mon Sep 15 00:00:00 EDT 2014
Genetic ablation of metadherin inhibits autochthonous prostate cancer progression and metastasis.
Cancer research
Wan L,Hu G,Wei Y,Yuan M,Bronson RT,Yang Q,Siddiqui J,Pienta KJ,Kang Y
Published figure using Metadherin polyclonal antibody (Product # 40-6500) in Immunohistochemistry
Mon Sep 15 00:00:00 EDT 2014
Exposure to cadmium chloride influences astrocyte-elevated gene-1 (AEG-1) expression in MDA-MB231 human breast cancer cells.
Biochimie
Luparello C,Longo A,Vetrano M
Sun Jan 01 00:00:00 EST 2012
