Product References
Phosphoproteomic of the acetylcholine pathway enables discovery of the PKC-β-PIX-Rac1-PAK cascade as a stimulatory signal for aversive learning.
Molecular psychiatry
Yamahashi Y,Lin YH,Mouri A,Iwanaga S,Kawashima K,Tokumoto Y,Watanabe Y,Faruk MO,Zhang X,Tsuboi D,Nakano T,Saito N,Nagai T,Yamada K,Kaibuchi K
44-940G was used in Immunohistochemistry to demonstrate that acetylcholine stimulates M1R-PKC-β-PIX-Rac1-PAK signaling in D2R-MSNs for aversive learning and imply the cascade's therapeutic potential for AD as aversive learning is used to preliminarily screen AD drugs.
Mon Aug 01 00:00:00 EDT 2022
Activating RAC1 variants in the switch II region cause a developmental syndrome and alter neuronal morphology.
Brain : a journal of neurology
Banka S,Bennington A,Baker MJ,Rijckmans E,Clemente GD,Ansor NM,Sito H,Prasad P,Anyane-Yeboa K,Badalato L,Dimitrov B,Fitzpatrick D,Hurst ACE,Jansen AC,Kelly MA,Krantz I,Rieubland C,Ross M,Rudy NL,Sanz J,Stouffs K,Xu ZL,Malliri A,Kazanietz MG,Millard TH
44-940G was used in Western Blot, Immunocytochemistry to reveal that these variants cause altered downstream signalling, resulting in abnormal neuronal morphology and reveal the WAVE regulatory complex/Arp2/3 pathway as a possible therapeutic target for activating RAC1 variants.
Mon Dec 19 00:00:00 EST 2022
Nck1, But Not Nck2, Mediates Disturbed Flow-Induced p21-Activated Kinase Activation and Endothelial Permeability.
Journal of the American Heart Association
Alfaidi M,Bhattarai U,Orr AW
44-940G was used in Western Blot to provide the first evidence that Nck1, but not the highly similar Nck2, plays a distinct role in disturbed flow-induced vascular permeability by selective p21-activated kinase activation.
Tue Jun 02 00:00:00 EDT 2020
Nck1, But Not Nck2, Mediates Disturbed Flow-Induced p21-Activated Kinase Activation and Endothelial Permeability.
Journal of the American Heart Association
Alfaidi M,Bhattarai U,Orr AW
44-940G was used in Western Blot to provide the first evidence that Nck1, but not the highly similar Nck2, plays a distinct role in disturbed flow-induced vascular permeability by selective p21-activated kinase activation.
Tue Jun 02 00:00:00 EDT 2020
Conditional Deletion of CC2D1A Reduces Hippocampal Synaptic Plasticity and Impairs Cognitive Function through Rac1 Hyperactivation.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Yang CY,Yu TH,Wen WL,Ling P,Hsu KS
44-940G was used in Western Blotting to establish a critical link between elevated Rac1 activity, structural and synaptic plasticity alterations, and cognitive impairment caused by Cc2d1a deletion.
Wed Jun 19 00:00:00 EDT 2019
Group I Paks are essential for epithelial- mesenchymal transition in an Apc-driven model of colorectal cancer.
Nature communications
Chow HY,Dong B,Valencia CA,Zeng CT,Koch JN,Prudnikova TY,Chernoff J
Published figure using Phospho-PAK1/2/3 (Ser141) polyclonal antibody (Product # 44-940G) in Western Blot
Mon Aug 27 00:00:00 EDT 2018
Transgenic autoinhibition of p21-activated kinase exacerbates synaptic impairments and fronto-dependent behavioral deficits in an animal model of Alzheimer's disease.
Aging
Bories C,Arsenault D,Lemire M,Tremblay C,De Koninck Y,Calon F
Published figure using Phospho-PAK1/2/3 (Ser141) polyclonal antibody (Product # 44-940G) in Western Blot
Tue May 16 00:00:00 EDT 2017
The calcium sensor Copine-6 regulates spine structural plasticity and learning and memory.
Nature communications
Reinhard JR,Kriz A,Galic M,Angliker N,Rajalu M,Vogt KE,Ruegg MA
44-940G was used in immunocytochemistry to determine regulation of spine structural plasticity and memory and learning by the calcium sensor Copine-6
Thu May 19 00:00:00 EDT 2016
A bead-based western for high-throughput cellular signal transduction analyses.
Nature communications
Treindl F,Ruprecht B,Beiter Y,Schultz S,Döttinger A,Staebler A,Joos TO,Kling S,Poetz O,Fehm T,Neubauer H,Kuster B,Templin MF
44-940G was used in western blot identify and characterize alterations in signal transduction that occur during the development Lapatinib resistance
Fri Sep 23 00:00:00 EDT 2016
The matrikine N-α-PGP couples extracellular matrix fragmentation to endothelial permeability.
Science advances
Hahn CS,Scott DW,Xu X,Roda MA,Payne GA,Wells JM,Viera L,Winstead CJ,Bratcher P,Sparidans RW,Redegeld FA,Jackson PL,Folkerts G,Blalock JE,Patel RP,Gaggar A
44-940G was used in western blot to assess the contribution of tissue damage and extracellular matrix fragmentation during inflammation.
Mon Oct 19 00:00:00 EDT 2020
Group I Paks as therapeutic targets in NF2-deficient meningioma.
Oncotarget
Chow HY,Dong B,Duron SG,Campbell DA,Ong CC,Hoeflich KP,Chang LS,Welling DB,Yang ZJ,Chernoff J
Published figure using Phospho-PAK1/2/3 (Ser141) polyclonal antibody (Product # 44-940G) in Western Blot
Tue Feb 10 00:00:00 EST 2015
Pharmacological stimulation of the brain serotonin receptor 7 as a novel therapeutic approach for Rett syndrome.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
De Filippis B,Nativio P,Fabbri A,Ricceri L,Adriani W,Lacivita E,Leopoldo M,Passarelli F,Fuso A,Laviola G
44-940G was used in western blot to study 5-HT7R in a mouse model of Rett syndrome.
Wed Oct 01 00:00:00 EDT 2014
Lis1 mediates planar polarity of auditory hair cells through regulation of microtubule organization.
Development (Cambridge, England)
Sipe CW,Liu L,Lee J,Grimsley-Myers C,Lu X
44-940G was used in western blot to elucidate the hair cell-intrinsic polarity machinery.
Mon Apr 01 00:00:00 EDT 2013
Glucocorticoid receptors are localized to dendritic spines and influence local actin signaling.
Molecular neurobiology
Jafari M,Seese RR,Babayan AH,Gall CM,Lauterborn JC
44-940G was used in western blot to study glucocorticoid signaling in the spine.
Mon Oct 01 00:00:00 EDT 2012
Glucocorticoid receptors are localized to dendritic spines and influence local actin signaling.
Molecular neurobiology
Jafari M,Seese RR,Babayan AH,Gall CM,Lauterborn JC
44-940G was used in western blot to study glucocorticoid signaling in the spine.
Mon Oct 01 00:00:00 EDT 2012
Physiological activation of synaptic Rac>PAK (p-21 activated kinase) signaling is defective in a mouse model of fragile X syndrome.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Chen LY,Rex CS,Babayan AH,Kramár EA,Lynch G,Gall CM,Lauterborn JC
Wed Aug 18 00:00:00 EDT 2010
Exercise improves cognition and hippocampal plasticity in APOE epsilon4 mice.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Nichol K,Deeny SP,Seif J,Camaclang K,Cotman CW
Wed Jul 01 00:00:00 EDT 2009
Loss of modifier of cell adhesion reveals a pathway leading to axonal degeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Chen Q,Peto CA,Shelton GD,Mizisin A,Sawchenko PE,Schubert D
Wed Jan 07 00:00:00 EST 2009
Cytoskeletal changes underlie estrogen's acute effects on synaptic transmission and plasticity.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Kramár EA,Chen LY,Brandon NJ,Rex CS,Liu F,Gall CM,Lynch G
Published figure using Phospho-PAK1/2/3 (Ser141) polyclonal antibody (Product # 44-940G) in Western Blot
Wed Oct 14 00:00:00 EDT 2009
Signal transduction in Alzheimer disease: p21-activated kinase signaling requires C-terminal cleavage of APP at Asp664.
Journal of neurochemistry
Nguyen TV,Galvan V,Huang W,Banwait S,Tang H,Zhang J,Bredesen DE
Published figure using Phospho-PAK1/2/3 (Ser141) polyclonal antibody (Product # 44-940G) in Immunofluorescence
Fri Feb 01 00:00:00 EST 2008
Signal transduction in Alzheimer disease: p21-activated kinase signaling requires C-terminal cleavage of APP at Asp664.
Journal of neurochemistry
Nguyen TV,Galvan V,Huang W,Banwait S,Tang H,Zhang J,Bredesen DE
Published figure using Phospho-PAK1/2/3 (Ser141) polyclonal antibody (Product # 44-940G) in Immunofluorescence
Fri Feb 01 00:00:00 EST 2008
Signal transduction in Alzheimer disease: p21-activated kinase signaling requires C-terminal cleavage of APP at Asp664.
Journal of neurochemistry
Nguyen TV,Galvan V,Huang W,Banwait S,Tang H,Zhang J,Bredesen DE
Published figure using Phospho-PAK1/2/3 (Ser141) polyclonal antibody (Product # 44-940G) in Immunofluorescence
Fri Feb 01 00:00:00 EST 2008
Signal transduction in Alzheimer disease: p21-activated kinase signaling requires C-terminal cleavage of APP at Asp664.
Journal of neurochemistry
Nguyen TV,Galvan V,Huang W,Banwait S,Tang H,Zhang J,Bredesen DE
Published figure using Phospho-PAK1/2/3 (Ser141) polyclonal antibody (Product # 44-940G) in Immunofluorescence
Fri Feb 01 00:00:00 EST 2008
Signal transduction in Alzheimer disease: p21-activated kinase signaling requires C-terminal cleavage of APP at Asp664.
Journal of neurochemistry
Nguyen TV,Galvan V,Huang W,Banwait S,Tang H,Zhang J,Bredesen DE
Published figure using Phospho-PAK1/2/3 (Ser141) polyclonal antibody (Product # 44-940G) in Immunofluorescence
Fri Feb 01 00:00:00 EST 2008
Signal transduction in Alzheimer disease: p21-activated kinase signaling requires C-terminal cleavage of APP at Asp664.
Journal of neurochemistry
Nguyen TV,Galvan V,Huang W,Banwait S,Tang H,Zhang J,Bredesen DE
Published figure using Phospho-PAK1/2/3 (Ser141) polyclonal antibody (Product # 44-940G) in Immunofluorescence
Fri Feb 01 00:00:00 EST 2008
Brain-derived neurotrophic factor promotes long-term potentiation-related cytoskeletal changes in adult hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Rex CS,Lin CY,Kramár EA,Chen LY,Gall CM,Lynch G
Published figure using Phospho-PAK1/2/3 (Ser141) polyclonal antibody (Product # 44-940G) in Western Blot
Wed Mar 14 00:00:00 EDT 2007
Changes in synaptic morphology accompany actin signaling during LTP.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Chen LY,Rex CS,Casale MS,Gall CM,Lynch G
Wed May 16 00:00:00 EDT 2007
p21-activated kinase regulates endothelial permeability through modulation of contractility.
The Journal of biological chemistry
Stockton RA,Schaefer E,Schwartz MA
Fri Nov 05 00:00:00 EST 2004
p21-activated kinase regulates endothelial permeability through modulation of contractility.
The Journal of biological chemistry
Stockton RA,Schaefer E,Schwartz MA
Fri Nov 05 00:00:00 EST 2004
