Product References
3-oxo-C12:2-HSL, quorum sensing molecule from human intestinal microbiota, inhibits pro-inflammatory pathways in immune cells via bitter taste receptors.
Scientific reports
Coquant G,Aguanno D,Brot L,Belloir C,Delugeard J,Roger N,Pham HP,Briand L,Moreau M,de Sordi L,Carrière V,Grill JP,Thenet S,Seksik P
44-422G was used in Simple Western - Size to unravell the involvement of several cellular pathways in the anti-inflammatory effects exerted by the QS molecule 3-oxo-C12:2-HSL.
Wed Jun 08 00:00:00 EDT 2022
Drug target validation in primary human natural killer cells using CRISPR RNP.
Journal of leukocyte biology
Rautela J,Surgenor E,Huntington ND
44-422G was used in Western Blot to show an efficient approach to genetically edit human NK cells by electroporation and CRISPR-Cas9 ribonucleoprotein complexes.
Thu Oct 01 00:00:00 EDT 2020
ATM‑JAK‑PD‑L1 signaling pathway inhibition decreases EMT and metastasis of androgen‑independent prostate cancer.
Molecular medicine reports
Zhang L,Xu LJ,Zhu J,Li J,Xue BX,Gao J,Sun CY,Zang YC,Zhou YB,Yang DR,Shan YX
44-422G was used in Western Blotting to suggest that ATM-JAK-PD-L1 signalling pathway inhibition can effectively suppress EMT, metastasis and progression of CRPC.
Tue May 01 00:00:00 EDT 2018
Sulfated non-anticoagulant heparin blocks Th2-induced asthma by modulating the IL-4/signal transducer and activator of transcription 6/Janus kinase 1 pathway.
Journal of translational medicine
Ghonim MA,Wang J,Ibba SV,Luu HH,Pyakurel K,Benslimane I,Mousa S,Boulares AH
44-422G was used in Western Blotting to study the potential of sulphated-non-coagulant heparin in blocking allergic asthma and examine the potential mechanism by which it exerts its effects.
Sat Sep 01 00:00:00 EDT 2018
ALK-activating homologous mutations in LTK induce cellular transformation.
PloS one
Roll JD,Reuther GW
44-422G was used in western blot to examine the transforming potential of leukocyte tyrosine kinase
Tue Jul 31 00:00:00 EDT 2012
ALK-activating homologous mutations in LTK induce cellular transformation.
PloS one
Roll JD,Reuther GW
44-422G was used in western blot to examine the transforming potential of leukocyte tyrosine kinase
Tue Jul 31 00:00:00 EDT 2012
IL-6 promotes head and neck tumor metastasis by inducing epithelial-mesenchymal transition via the JAK-STAT3-SNAIL signaling pathway.
Molecular cancer research : MCR
Yadav A,Kumar B,Datta J,Teknos TN,Kumar P
44-422G was used in western blot to determine the function of IL-6 in the epithelial-mesenchymal transition in head and neck tumor cells.
Thu Dec 01 00:00:00 EST 2011
IL-2 induces conformational changes in its preassembled receptor core, which then migrates in lipid raft and binds to the cytoskeleton meshwork.
Journal of molecular biology
Pillet AH,Lavergne V,Pasquier V,Gesbert F,Thèze J,Rose T
44-422G was used in western blot to study the assembly of full-length IL-2R at the surface of living lymphocytes
Fri Nov 12 00:00:00 EST 2010
Transforming JAK1 mutations exhibit differential signalling, FERM domain requirements and growth responses to interferon-γ.
The Biochemical journal
Gordon GM,Lambert QT,Daniel KG,Reuther GW
Published figure using Phospho-JAK1 (Tyr1022, Tyr1023) polyclonal antibody (Product # 44-422G) in Western Blot
Wed Dec 01 00:00:00 EST 2010
Transforming JAK1 mutations exhibit differential signalling, FERM domain requirements and growth responses to interferon-γ.
The Biochemical journal
Gordon GM,Lambert QT,Daniel KG,Reuther GW
Published figure using Phospho-JAK1 (Tyr1022, Tyr1023) polyclonal antibody (Product # 44-422G) in Western Blot
Wed Dec 01 00:00:00 EST 2010
SOCS-1 binding to tyrosine 441 of IFN-gamma receptor subunit 1 contributes to the attenuation of IFN-gamma signaling in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Starr R,Fuchsberger M,Lau LS,Uldrich AP,Goradia A,Willson TA,Verhagen AM,Alexander WS,Smyth MJ
44-422G was used in western blot to elucidate how suppressor of cytokine signaling-1 regulates IFN-gamma receptor subunit 1 using a new mouse model.
Thu Oct 01 00:00:00 EDT 2009
'Tuning' of type I interferon-induced Jak-STAT1 signaling by calcium-dependent kinases in macrophages.
Nature immunology
Wang L,Tassiulas I,Park-Min KH,Reid AC,Gil-Henn H,Schlessinger J,Baron R,Zhang JJ,Ivashkiv LB
44-422G was used in western blot to study the function of CaMK and Pyk2 downstream of ITAM-associated receptors in the regulation of cytokine-induced activation of Jak kinases and STAT transcription factors
Fri Feb 01 00:00:00 EST 2008
Molecular mechanisms involved in interleukin-4-induced human neutrophils: expression and regulation of suppressor of cytokine signaling.
Journal of leukocyte biology
Ratthé C,Pelletier M,Chiasson S,Girard D
Tue May 01 00:00:00 EDT 2007
Erythropoietin protects the infant heart against ischemia-reperfusion injury by triggering multiple signaling pathways.
Basic research in cardiology
Rafiee P,Shi Y,Su J,Pritchard KA,Tweddell JS,Baker JE
Sun May 01 00:00:00 EDT 2005
Falcarindiol impairs the expression of inducible nitric oxide synthase by abrogating the activation of IKK and JAK in rat primary astrocytes.
British journal of pharmacology
Shiao YJ,Lin YL,Sun YH,Chi CW,Chen CF,Wang CN
Sat Jan 01 00:00:00 EST 2005
Mumps virus V protein antagonizes interferon without the complete degradation of STAT1.
Journal of virology
Kubota T,Yokosawa N,Yokota S,Fujii N,Tashiro M,Kato A
Fri Apr 01 00:00:00 EST 2005
Mumps virus V protein antagonizes interferon without the complete degradation of STAT1.
Journal of virology
Kubota T,Yokosawa N,Yokota S,Fujii N,Tashiro M,Kato A
Fri Apr 01 00:00:00 EST 2005
Activation of the JAK/STAT pathway in vascular smooth muscle by serotonin.
American journal of physiology. Cell physiology
Banes AK,Shaw SM,Tawfik A,Patel BP,Ogbi S,Fulton D,Marrero MB
Fri Apr 01 00:00:00 EST 2005
Role of tyrosine 441 of interferon-gamma receptor subunit 1 in SOCS-1-mediated attenuation of STAT1 activation.
The Journal of biological chemistry
Qing Y,Costa-Pereira AP,Watling D,Stark GR
Fri Jan 21 00:00:00 EST 2005
Growth arrest of epithelial cells during measles virus infection is caused by upregulation of interferon regulatory factor 1.
Journal of virology
Yokota S,Okabayashi T,Yokosawa N,Fujii N
Sat May 01 00:00:00 EDT 2004
Functional expression of the interleukin-11 receptor alpha-chain and evidence of antiapoptotic effects in human colonic epithelial cells.
The Journal of biological chemistry
Kiessling S,Muller-Newen G,Leeb SN,Hausmann M,Rath HC,Strater J,Spottl T,Schlottmann K,Grossmann J,Montero-Julian FA,Scholmerich J,Andus T,Buschauer A,Heinrich PC,Rogler G
Fri Mar 12 00:00:00 EST 2004
C-terminal region of STAT-1alpha is not necessary for its ubiquitination and degradation caused by mumps virus V protein.
Journal of virology
Yokosawa N,Yokota S,Kubota T,Fujii N
Sun Dec 01 00:00:00 EST 2002
