Invitrogen

MyD88 Monoclonal Antibody (2E9C2)

View all (38) MyD88 antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-15762

Applications
Tested Dilution
Publications

Western Blot (WB)

2 µg/mL
-

Immunohistochemistry (IHC)

2.5 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

2E9C2

Immunogen

Recombinant protein corresponding to amino acids 176 to 280 of human MyD88.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_11153821

Product Specific Information

A suggested positive control is EL4 cell lysate.

Target Information

Myeloid differentiation Marker 88 (MyD88) is an adaptor molecule for the Toll/IL-1R and is involved in the inflammatory response induced by IL-1, IL-18 and LPS. MyD88 recruits IRAK to IL-1 receptor complex in response to IL-1. This pathway further leads to activation of NF-kB. MyD88 has a wide tissue distribution.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: mutant myeloid differentiation primary response 88; myeloid differentiation primary response gene (88); Myeloid differentiation primary response protein MyD88

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Gene Aliases: MYD88; MYD88D

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UniProt ID: (Human) Q99836, (Mouse) P22366

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Entrez Gene ID: (Human) 4615, (Mouse) 17874

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Function(s)
death receptor binding protein binding identical protein binding protein self-association TIR domain binding receptor binding Toll binding interleukin-1 receptor binding scaffold/adaptor protein
Process(es)
toll-like receptor signaling pathway MyD88-dependent toll-like receptor signaling pathway apoptotic process inflammatory response signal transduction cell surface receptor signaling pathway positive regulation of type I interferon production positive regulation of interleukin-17 production positive regulation of interleukin-23 production positive regulation of interleukin-6 production toll-like receptor 9 signaling pathway negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response regulation of inflammatory response defense response to Gram-positive bacterium positive regulation of NF-kappaB transcription factor activity response to interleukin-1 3'-UTR-mediated mRNA stabilization cellular response to mechanical stimulus response to molecule of fungal origin immune system process immune response transmembrane receptor protein serine/threonine kinase signaling pathway JNK cascade Toll signaling pathway response to virus immunoglobulin mediated immune response cytokine-mediated signaling pathway lipopolysaccharide-mediated signaling pathway response to peptidoglycan response to lipopolysaccharide positive regulation of tumor necrosis factor production regulation of cell proliferation negative regulation of growth of symbiont in host positive regulation of chemokine biosynthetic process type I interferon biosynthetic process positive regulation of JNK cascade positive regulation of smooth muscle cell proliferation positive regulation of lymphocyte proliferation establishment of endothelial intestinal barrier
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