Product References
High VEGFR3 Expression Reduces Doxorubicin Efficacy in Triple-Negative Breast Cancer.
International journal of molecular sciences
Torres-Ruiz S,Tormo E,Garrido-Cano I,Lameirinhas A,Rojo F,Madoz-Gúrpide J,Burgués O,Hernando C,Bermejo B,Martínez MT,Lluch A,Cejalvo JM,Eroles P
MA5-15738 was used in Western Blotting to evaluate the expression of the main lymphangiogenic receptor VEGFR3 in two triple-negative breast cancer in vitro models, resistant or not to doxorubicin treatment.
Fri Feb 10 00:00:00 EST 2023
Chemical inhibition of DNA-PKcs impairs the activation and cytotoxicity of CD4+ helper and CD8+ effector T cells.
Immunology and cell biology
Azevedo-Pouly AC,Appell LE,Burdine L,Rogers LJ,Morehead LC,Fil D,Barker M,Rainwater RR,Waldrip ZJ,Koss B,Burdine MS
MA5-15738 was used in Western Blot to highlight a critical role for DNA-PKcs in T cells and validate future studies using DNA-PKcs inhibitors as immune modulation therapy for the treatment of immune-related diseases.
Tue Aug 01 00:00:00 EDT 2023
Synergistic Combination of Luteolin and Asiatic Acid on Cervical Cancer In Vitro and In Vivo.
Cancers
Chen YH,Wu JX,Yang SF,Hsiao YH
MA5-15738 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to show that Lut combined with AsA may be used as an anticancer agent to improve the prognosis of cervical cancer.
Mon Jan 16 00:00:00 EST 2023
Rapid cell type-specific nascent proteome labeling in Drosophila.
eLife
Villalobos-Cantor S,Barrett RM,Condon AF,Arreola-Bustos A,Rodriguez KM,Cohen MS,Martin I
MA5-15738 was used in Western Blot to show that cell type-specific PGA expression in Drosophila can be used to achieve OPP labeling of newly-synthesized proteins in targeted cell populations within the brain.
Mon Apr 24 00:00:00 EDT 2023
Aim18p and Aim46p are chalcone isomerase domain-containing mitochondrial hemoproteins in Saccharomyces cerevisiae.
The Journal of biological chemistry
Schmitz JM,Wolters JF,Murray NH,Guerra RM,Bingman CA,Hittinger CT,Pagliarini DJ
MA5-15738 was used in Western Blotting to reveal a distinct function and cellular localization for two CHI-like proteins, introduces a new variation of a hemoprotein fold, and suggests that ancestral CHI-like proteins were hemoproteins.
Wed Mar 01 00:00:00 EST 2023
Uremic Toxin-Induced Exosome-like Extracellular Vesicles Contain Enhanced Levels of Sulfated Glycosaminoglycans which Facilitate the Interaction with Very Small Superparamagnetic Iron Oxide Particles.
International journal of molecular sciences
Freise C,Zappe A,Löwa N,Schnorr J,Pagel K,Wiekhorst F,Taupitz M
MA5-15738 was used in Western Blot to study the effects of uremic toxins on the abundance of sulfated glycosaminoglycans (GAGs) in EVs, and the implications for binding of ligands such as very small superparamagnetic iron oxide particles (VSOPs) which could be of relevance for radiological EV-imaging.
Mon Sep 18 00:00:00 EDT 2023
The histone H3/H4 chaperone CHAF1B prevents the mislocalization of CENP-A for chromosomal stability.
Journal of cell science
Shrestha RL,Balachandra V,Kim JH,Rossi A,Vadlamani P,Sethi SC,Ozbun L,Lin S,Cheng KC,Chari R,Karpova TS,Pegoraro G,Foltz DR,Caplen NJ,Basrai MA
MA5-15738 was used in Western Blotting to identify regulators of CENP-A localization and defined a role for CHAF1B in preventing DAXX-dependent CENP-A mislocalization and CIN.
Mon May 15 00:00:00 EDT 2023
Reduction in CgA-Derived CST Protein Level in HTR-8/SVneo and BeWo Trophoblastic Cell Lines Caused by the Preeclamptic Environment.
International journal of molecular sciences
Bralewska M,Pietrucha T,Sakowicz A
MA5-15738 was used in Western Blotting to provide the first evidence that CgA and CST proteins are produced by trophoblastic cell lines and that the PE environment has an impact on CST protein production.
Wed Apr 12 00:00:00 EDT 2023
Assessing the Activity of Transcription Factor FoxO1.
Methods in molecular biology (Clifton, N.J.)
Shi L,Tao Z,Cheng Z
MA5-15738 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to assess FoxO1 transactivation activity.
Mon Oct 24 00:00:00 EDT 2022
Lactate promotes endothelial-to-mesenchymal transition via Snail1 lactylation after myocardial infarction.
Science advances
Fan M,Yang K,Wang X,Chen L,Gill PS,Ha T,Liu L,Lewis NH,Williams DL,Li C
MA5-15738 was used in Western Blot to conclude that lactate acts as an important molecule that up-regulates cardiac.
Fri Feb 03 00:00:00 EST 2023
In-situ forming injectable GFOGER-conjugated BMSCs-laden hydrogels for osteochondral regeneration.
NPJ Regenerative medicine
Ha MY,Yang DH,You SJ,Kim HJ,Chun HJ
MA5-15738 was used in Western Blotting to provide an important platform for further advanced GFOGER-based stem cell research for osteochondral repair.
Fri Jan 06 00:00:00 EST 2023
Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation.
Cell reports
Meyers AK,Wang Z,Han W,Zhao Q,Zabalawi M,Duan L,Liu J,Zhang Q,Manne RK,Lorenzo F,Quinn MA,Song Q,Fan D,Lin HK,Furdui CM,Locasale JW,McCall CE,Zhu X
MA5-15738 was used in Western Blot to suggest a non-canonical role of mitochondrial PDHK in promoting mitochondrial stress and supporting NLRP3 inflammasome activation during acute inflammation.
Tue Jan 31 00:00:00 EST 2023
Transfusion with Blood Plasma from Young Mice Affects rTg4510 Transgenic Tau Mice Modeling of Alzheimer's Disease.
Brain sciences
Hernandez CM,Barkey RE,Craven KM,Pedemonte KA,Alisantosa B,Sanchez JO,Flinn JM
MA5-15738 was used in Western Blot to find that Tau mice injected with plasma had lower expression of phosphorylated tau (ptau) in the brain, accompanied by fewer tau tangles in the cortex and CA1 region of the hippocampus and smaller tau tangles in the cortex, when compared to Tau mice injected with saline.
Tue May 23 00:00:00 EDT 2023
DDOST-CDG: Clinical and molecular characterization of a third patient with a milder and a predominantly movement disorder phenotype.
Journal of inherited metabolic disease
Elsharkawi I,Wongkittichote P,Daniel EJP,Starosta RT,Ueda K,Ng BG,Freeze HH,He M,Shinawi M
MA5-15738 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to highlight the clinical variability, expand the clinical and biochemical phenotypes, and describe new genotype, which all are essential for diagnosing and managing patients with DDOST-CDG.
Sun Jan 01 00:00:00 EST 2023
Involvement of Mitochondrial Dysfunction in FOXG1 Syndrome.
Genes
Bjerregaard VA,Levy AM,Batz MS,Salehi R,Hildonen M,Hammer TB,Møller RS,Desler C,Tümer Z
MA5-15738 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to investigate whether defective FOXG1 leads to mitochondrial dysfunction in five individuals with FOXG1 variants compared to controls (n = 6).
Tue Jan 17 00:00:00 EST 2023
Low-Molecular-Weight β-1,3-1,6-Glucan Derived from Aureobasidium pullulans Exhibits Anticancer Activity by Inducing Apoptosis in Colorectal Cancer Cells.
Biomedicines
Kim JH,Seo J,No H,Kuge T,Mori T,Kimoto H,Kim JK
MA5-15738 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to report that low-molecular-weight Aureobasidium pullulans-fermented β-D-glucan (LMW-AP-FBG) could inhibit inflammatory responses by inhibiting mitogen-activated protein kinases and nuclear factor-κB signaling pathways.
Sat Feb 11 00:00:00 EST 2023
Low frequency repetitive transcranial magnetic stimulation promotes plasticity of the visual cortex in adult amblyopic rats.
Frontiers in neuroscience
Zheng J,Zhang W,Liu L,Hung Yap MK
MA5-15738 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to provide further evidence that rTMS enhances functional recovery and visual plasticity in an adult amblyopic animal model.
Tue Feb 07 00:00:00 EST 2023
Loss of oligodendrocyte ErbB receptor signaling leads to hypomyelination, reduced density of parvalbumin-expressing interneurons, and inhibitory function in the auditory cortex.
Glia
Borges BC,Meng X,Long P,Kanold PO,Corfas G
MA5-15738 was used in Western Blotting to indicate that mild hypomyelination impacts A1 neuronal networks, reducing inhibitory activity, and shifting networks towards excitation.
Wed Feb 01 00:00:00 EST 2023
miR-146a-5p Promotes Angiogenesis and Confers Trastuzumab Resistance in HER2+ Breast Cancer.
Cancers
Cabello P,Torres-Ruiz S,Adam-Artigues A,Forés-Martos J,Martínez MT,Hernando C,Zazo S,Madoz-Gúrpide J,Rovira A,Burgués O,Rojo F,Albanell J,Lluch A,Bermejo B,Cejalvo JM,Eroles P
MA5-15738 was used in Western Blotting to support the role of miR-146a-5p in resistance to trastuzumab, and demonstrate that it can be transferred by exosomes conferring resistance properties to other cells.
Tue Apr 04 00:00:00 EDT 2023
Dental Pulp Stem Cell-Derived Conditioned Medium Alleviates Subarachnoid Hemorrhage-Induced Microcirculation Impairment by Promoting M2 Microglia Polarization and Reducing Astrocyte Swelling.
Translational stroke research
Yang LY,Chen YR,Lee JE,Chen KW,Luh HT,Chen YT,Wang KC,Hsieh ST
MA5-15738 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to suggest that DPSC-CM significantly reduced brain edema and rescued microcirculation impairment with concomitant anti-inflammatory benefits after SAH, and may potentially be developed into a novel therapeutic strategy for SAH.
Sun Oct 01 00:00:00 EDT 2023
Role of human HSPE1 for OPA1 processing independent of HSPD1.
iScience
Yeung N,Murata D,Iijima M,Sesaki H
MA5-15738 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to suggest that HSPE1 controls mitochondrial morphology through a mechanism separate from its chaperonin activity.
Fri Feb 17 00:00:00 EST 2023
A dynamic actin cytoskeleton is required to prevent constitutive VDAC-dependent MAPK signalling and aberrant lipid homeostasis.
iScience
Davis J,Meyer T,Smolnig M,Smethurst DGJ,Neuhaus L,Heyden J,Broeskamp F,Edrich ESM,Knittelfelder O,Kolb D,Haar TV,Gourlay CW,Rockenfeller P
MA5-15738 was used in Western Blotting to show that cofilin-driven chronic depolarization of the actin cytoskeleton activates cell wall integrity mitogen-activated protein kinase (MAPK) signalling and disrupts lipid homeostasis in a voltage-dependent anion channel (VDAC)-dependent manner.
Fri Sep 15 00:00:00 EDT 2023
Curcumin Has Beneficial Effects on Lysosomal Alpha-Galactosidase: Potential Implications for the Cure of Fabry Disease.
International journal of molecular sciences
Monticelli M,Hay Mele B,Allocca M,Liguori L,Lukas J,Monti MC,Morretta E,Cubellis MV,Andreotti G
MA5-15738 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to confirm the necessity of personalized therapies for Fabry patients and paved the way to further studies and trials of treatments for Fabry disease.
Fri Jan 06 00:00:00 EST 2023
Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage.
Nature communications
Rosado-Ramos R,Poças GM,Marques D,Foito A,M Sevillano D,Lopes-da-Silva M,Gonçalves LG,Menezes R,Ottens M,Stewart D,Ibáñez de Opakua A,Zweckstetter M,Seabra MC,Mendes CS,Outeiro TF,Domingos PM,Santos CN
MA5-15738 was used in Western Blotting to identify genipin, an iridoid, which relieves αSyn toxicity and aggregation.
Thu Apr 06 00:00:00 EDT 2023
LRRK2 Kinase Inhibition Attenuates Astrocytic Activation in Response to Amyloid β1-42 Fibrils.
Biomolecules
Filippini A,Salvi V,Dattilo V,Magri C,Castrezzati S,Veerhuis R,Bosisio D,Gennarelli M,Russo I
MA5-15738 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to report that LRRK2 kinase activity modulates astrocytic reactivity and functions in the presence of Aβ1-42 deposits and indicate that PD-linked LRRK2 might contribute to AD-related neuroinflammation and pathogenesis.
Mon Feb 06 00:00:00 EST 2023
Molecular features driving condensate formation and gene expression by the BRD4-NUT fusion oncoprotein are overlapping but distinct.
Scientific reports
Kosno M,Currie SL,Kumar A,Xing C,Rosen MK
MA5-15738 was used in Western Blotting to suggest a model for condensate formation by the BRD4-NUT:p300 complex involving a combination of positive feedback and phase separation, and show that multiple overlapping, yet distinct, regions of p300 contribute to condensate formation and transcriptional regulation.
Mon Jul 24 00:00:00 EDT 2023
LRRK2 Kinase Inhibition Attenuates Neuroinflammation and Cytotoxicity in Animal Models of Alzheimer's and Parkinson's Disease-Related Neuroinflammation.
Cells
Mutti V,Carini G,Filippini A,Castrezzati S,Giugno L,Gennarelli M,Russo I
MA5-15738 was used in Western Blotting to validate LRRK2 kinase modulation as a pharmacological intervention in preclinical models of AD- and PD-related neuroinflammation.
Thu Jul 06 00:00:00 EDT 2023
Ketorolac modulates Rac-1/HIF-1α/DDX3/β-catenin signalling via a tumor suppressor prostate apoptosis response-4 (Par-4) in renal cell carcinoma.
Scientific reports
Sonawane V,Ghosalkar J,Achrekar S,Joshi K
MA5-15738 was used in Western Blotting to elucidated the role of Ketorolac, a modulator Rho-GTPases against renal cell carcinoma through potentiation of tumor suppressor Par-4.
Thu Apr 06 00:00:00 EDT 2023
Schlafen4+-MDSC in Helicobacter-induced gastric metaplasia reveals role for GTPases.
Frontiers in immunology
Ding L,Sheriff S,Sontz RA,Merchant JL
MA5-15738 was used in Western Blotting to characterize SLFN4+ cell identity and the role of Slfn4 in these cells.
Tue Jun 20 00:00:00 EDT 2023
Tubulin tyrosination regulates synaptic function and is disrupted in Alzheimer's disease.
Brain : a journal of neurology
Peris L,Parato J,Qu X,Soleilhac JM,Lanté F,Kumar A,Pero ME,Martínez-Hernández J,Corrao C,Falivelli G,Payet F,Gory-Fauré S,Bosc C,Blanca Ramirez M,Sproul A,Brocard J,Di Cara B,Delagrange P,Buisson A,Goldberg Y,Moutin MJ,Bartolini F,Andrieux A
MA5-15738 was used in Western Blot to demonstrate that a balanced tyrosination/detyrosination tubulin cycle is necessary for the maintenance of synaptic plasticity, is protective against amyloid β peptide-induced synaptic damage, and that this balance is lost in Alzheimer's disease, providing evidence that defective tubulin retyrosination may contribute to circuit dysfunction during neurodegeneration in Alzheimer's disease.
Fri Jul 29 00:00:00 EDT 2022
Parecoxib inhibits esophageal squamous cell carcinoma progression via the PDK1-AKT pathway.
Cellular & molecular biology letters
Huang HM,Huang XY,Wu SP,Chen CK,He XH,Zhang YF
MA5-15738 was used in Western Blot to conclude that parecoxib inhibits ESCC progression, including cell cycle, proliferation, invasion, and migration, via the PDK1-AKT signaling pathway.
Sat Mar 19 00:00:00 EDT 2022
Structurally Conserved Domains between Flavivirus and Alphavirus Fusion Glycoproteins Contribute to Replication and Infectious-Virion Production.
Journal of virology
Rangel MV,Catanzaro N,Thannickal SA,Crotty KA,Noval MG,Johnson KEE,Ghedin E,Lazear HM,Stapleford KA
MA5-15738 was used in Immuno-assay to highlight how class II fusion proteins function and provide novel targets for development of antivirals.
Wed Jan 26 00:00:00 EST 2022
Inhibition of LncRNA Vof-16 expression promotes nerve regeneration and functional recovery after spinal cord injury.
Neural regeneration research
Zhang XM,Zeng LN,Yang WY,Ding L,Chen KZ,Fu WJ,Zeng SQ,Liang YR,Chen GH,Wu HF
MA5-15738 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to suggest that lncRNA Vof-16 is associated with the regulation of inflammation and apoptosis.
Sat Jan 01 00:00:00 EST 2022
The c-Myc Oncogene Maintains Corneal Epithelial Architecture at Homeostasis, Modulates p63 Expression, and Enhances Proliferation During Tissue Repair.
Investigative ophthalmology & visual science
Portal C,Wang Z,Scott DK,Wolosin JM,Iomini C
MA5-15738 was used in Western Blot to show that Myc regulates the balance among CE stratification, differentiation, and surface exfoliation and promotes the transition to the hyperproliferative state during wound healing.
Tue Feb 01 00:00:00 EST 2022
Schistosoma mansoni phosphoglycerate mutase: a glycolytic ectoenzyme with thrombolytic potential.
Parasite (Paris, France)
Pirovich DB,Da'dara AA,Skelly PJ
MA5-15738 was used in Western Blotting to support the hypothesis that host-interactive tegumental proteins (such as SmPGM), by enhancing plasmin formation, may help degrade blood clots around the worms in the vascular microenvironment and thus promote parasite survival in vivo.
Tue Sep 13 00:00:00 EDT 2022
Resistance to chemical carcinogenesis induction via a dampened inflammatory response in naked mole-rats.
Communications biology
Oka K,Fujioka S,Kawamura Y,Komohara Y,Chujo T,Sekiguchi K,Yamamura Y,Oiwa Y,Omamiuda-Ishikawa N,Komaki S,Sutoh Y,Sakurai S,Tomizawa K,Bono H,Shimizu A,Araki K,Yamamoto T,Yamada Y,Oshiumi H,Miura K
MA5-15738 was used in Western Blot to show that NMRs exhibit extraordinary resistance against potent chemical carcinogenesis induction through a dampened inflammatory response.
Wed Mar 30 00:00:00 EDT 2022
RAD18 opposes transcription-associated genome instability through FANCD2 recruitment.
PLoS genetics
Wells JP,Chang EY,Dinatto L,White J,Ryall S,Stirling PC
MA5-15738 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to highlight a RAD18-dependent pathway promoting FANCD2-mediated suppression of R-loops and transcription-replication conflicts.
Thu Dec 01 00:00:00 EST 2022
Male guanine-rich RNA sequence binding factor 1 knockout mice (Grsf1-/-) gain less body weight during adolescence and adulthood.
Cell & bioscience
Dumoulin B,Heydeck D,Jähn D,Lassé M,Sofi S,Ufer C,Kuhn H
MA5-15738 was used in Western Blotting to present, for the first time, an in vivo complete Grsf1 knock-out mouse with comprehensive physiological, transcriptomic and proteomic characterization to improve our understanding of the GRSF1 beyond in vitro cell culture models.
Fri Dec 09 00:00:00 EST 2022
The emergence of spontaneous coordinated epithelial rotation on cylindrical curved surfaces.
Science advances
Glentis A,Blanch-Mercader C,Balasubramaniam L,Saw TB,d'Alessandro J,Janel S,Douanier A,Delaval B,Lafont F,Lim CT,Delacour D,Prost J,Xi W,Ladoux B
MA5-15738 was used in Western Blotting to study the dynamics of epithelial layers lining different cylindrical surfaces.
Fri Sep 16 00:00:00 EDT 2022
4-Aminopyridine Induces Nerve Growth Factor to Improve Skin Wound Healing and Tissue Regeneration.
Biomedicines
Jagadeeshaprasad MG,Govindappa PK,Nelson AM,Noble MD,Elfar JC
MA5-15738 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to discover that 4-aminopyridine causes faster wound closure, restoration of normal-appearing skin architecture, and reinnervation.
Fri Jul 08 00:00:00 EDT 2022
Stalled replication fork protection limits cGAS-STING and P-body-dependent innate immune signalling.
Nature cell biology
Emam A,Wu X,Xu S,Wang L,Liu S,Wang B
MA5-15738 was used in Western Blotting to demonstrate a connection between replication stress and activation of the innate immune response that may be targeted for therapeutic purpose.
Fri Jul 01 00:00:00 EDT 2022
Downregulation of long noncoding RNA HCP5/miR-216a-5p/ZEB1 axis inhibits the malignant biological function of laryngeal squamous cell carcinoma cells.
Frontiers in immunology
Zhang S,Huangfu H,Zhao Q,Li Y,Wu L
MA5-15738 was used in Western Blotting to study the unknown effect and regulatory mechanism of the human leukocyte antigen complex P5 (HCP5) oncogene in laryngeal squamous cell carcinoma (LSCC) and to investigate whether HCP5 is a prospective therapeutic target for the treatment of LSCC.
Tue Oct 18 00:00:00 EDT 2022
Regulation of nuclear actin levels and MRTF/SRF target gene expression during PC6.3 cell differentiation.
Experimental cell research
Kyheröinen S,Hyrskyluoto A,Sokolova M,Vartiainen MK
MA5-15738 was used in Western Blotting to describe a novel cellular context, where regulation of nuclear actin is utilized to tune MRTF/SRF target gene expression during cell differentiation.
Tue Nov 15 00:00:00 EST 2022
Robust LC3B lipidation analysis by precisely adjusting autophagic flux.
Scientific reports
Liebl MP,Meister SC,Frey L,Hendrich K,Klemmer A,Wohlfart B,Untucht C,Nuber J,Pohl C,Lakics V
MA5-15738 was used in Western Blotting to propose that the creation of a sensitized background rather than a full block of autophagosome progression is required to quantitatively capture changes in autophagic flux.
Fri Jan 07 00:00:00 EST 2022
Multisite phosphorylation by Cdk1 initiates delayed negative feedback to control mitotic transcription.
Current biology : CB
Asfaha JB,Örd M,Carlson CR,Faustova I,Loog M,Morgan DO
MA5-15738 was used in Western Blotting to suggest that rising levels of mitotic Cdk1 activity act at multiple phosphorylation sites on Ndd1, first triggering rapid positive feedback and then promoting delayed negative feedback, resulting in a pulse of mitotic gene expression.
Mon Jan 10 00:00:00 EST 2022
Chronic Trazodone and Citalopram Treatments Increase Trophic Factor and Circadian Rhythm Gene Expression in Rat Brain Regions Relevant for Antidepressant Efficacy.
International journal of molecular sciences
Carboni L,Rullo L,Caputi FF,Stamatakos S,Candeletti S,Romualdi P
MA5-15738 was used in Western Blotting to show that trazodone affects the expression of neurotrophic factors involved in antidepressant responses and alters circadian rhythm genes implicated in the pathophysiology of depression, thus shedding light on trazodone's molecular mechanism of action.
Mon Nov 14 00:00:00 EST 2022
Dynamin-2 reduction rescues the skeletal myopathy of a SPEG-deficient mouse model.
JCI insight
Li Q,Lin J,Widrick JJ,Luo S,Li G,Zhang Y,Laporte J,Perrella MA,Liu X,Agrawal PB
MA5-15738 was used in Immunohistochemistry-immunofluorescence to evaluate the potential of dynamin-2 (DNM2) reduction as a potential therapeutic strategy as it has been shown to revert muscle phenotypes in mouse models of CNM caused by MTM1, DNM2, and BIN1 mutations.
Mon Aug 08 00:00:00 EDT 2022
BPR0C261, An Analogous of Microtubule Disrupting Agent D-24851 Enhances the Radiosensitivity of Human Non-Small Cell Lung Cancer Cells via p53-Dependent and p53-Independent Pathways.
International journal of molecular sciences
Leu JD,Lin ST,Chen CT,Chang CA,Lee YJ
MA5-15738 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to investigate if BPR0C261 could modulate the radiation response of human non-small cell lung cancer (NSCLC) cells with or without p53 expression.
Tue Nov 15 00:00:00 EST 2022
Toll-like Receptor 9 Pathway Mediates Schlafen+-MDSC Polarization During Helicobacter-induced Gastric Metaplasias.
Gastroenterology
Ding L,Chakrabarti J,Sheriff S,Li Q,Thi Hong HN,Sontz RA,Mendoza ZE,Schreibeis A,Helmrath MA,Zavros Y,Merchant JL
MA5-15738 was used in Western Blotting to propose that individuals with a more robust response to damage-activated molecular patterns and increased Toll-like receptor 9 (TLR9) expression are predisposed to the neoplastic complications of Helicobacter infection.
Mon Aug 01 00:00:00 EDT 2022
Human Papillomavirus 16 E6 and E7 Oncoproteins Alter the Abundance of Proteins Associated with DNA Damage Response, Immune Signaling and Epidermal Differentiation.
Viruses
Dust K,Carpenter M,Chen JC,Grant C,McCorrister S,Westmacott GR,Severini A
MA5-15738 was used in Western Blotting to identify dysregulated pathways and potential biomarkers associated with HPV oncoproteins in primary keratinocytes which may have therapeutic implications.
Fri Aug 12 00:00:00 EDT 2022
Age-Dependent and Pathway-Specific Bimodal Action of Nicotine on Synaptic Plasticity in the Hippocampus of Mice Lacking the miR-132/212 Genes.
Cells
Stojanovic T,Velarde Gamez D,Schuld GJ,Bormann D,Cabatic M,Uhrin P,Lubec G,Monje FJ
MA5-15738 was used in Western Blotting to propose miRNAs as age-sensitive bimodal regulators of hippocampal nicotinergic signaling and, given the relevance of the hippocampus for drug-related memory storage, encourage further research on the influence of miRNAs 132 and 212 in nicotine addiction in the young and the adult brain.
Thu Jan 13 00:00:00 EST 2022
Pressure and curvature control of the cell cycle in epithelia growing under spherical confinement.
Cell reports
Di Meglio I,Trushko A,Guillamat P,Blanch-Mercader C,Abuhattum S,Roux A
MA5-15738 was used in Western Blotting to show that epithelia growing under confinement accumulate pressure that inhibits proliferation above a threshold value.
Tue Aug 23 00:00:00 EDT 2022
TRF1 uses a noncanonical function of TFIIH to promote telomere replication.
Genes & development
Yang Z,Sharma K,de Lange T
MA5-15738 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to establish that the major mechanism by which TRF1 ensures telomere replication involves a noncanonical function of TFIIH.
Thu Sep 01 00:00:00 EDT 2022
COL10A1 allows stratification of invasiveness of colon cancer and associates to extracellular matrix and immune cell enrichment in the tumor parenchyma.
Frontiers in oncology
Kahlert UD,Shi W,Strecker M,Scherpinski LA,Wartmann T,Dölling M,Perrakis A,Relja B,Mengoni M,Braun A,Croner RS
MA5-15738 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to present new evidence that tumor tissue collagen type X alpha 1 (COL10A1) is a relevant candidate biomarker to improve treatment options for metastatic colorectal cancer (CRC).
Sat Oct 22 00:00:00 EDT 2022
Duck TRIM29 negatively regulates type I IFN production by targeting MAVS.
Frontiers in immunology
Li W,Song Y,Du Y,Huang Z,Zhang M,Chen Z,He Z,Ding Y,Zhang J,Zhao L,Sun H,Jiao P
MA5-15738 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to demonstrate that duTRIM29 negatively regulates type I IFN production by targeting duMAVS in ducks.
Tue Jan 24 00:00:00 EST 2023
NLRP3 Inflammasome Priming and Activation Are Regulated by a Phosphatidylinositol-Dependent Mechanism.
ImmunoHorizons
Hamilton C,Olona A,Leishman S,MacDonald-Ramsahai K,Cockcroft S,Larrouy-Maumus G,Anand PK
MA5-15738 was used in Western Blotting to reveal a novel metabolic-inflammatory circuit that contributes to calibrating immune responses.
Mon Aug 29 00:00:00 EDT 2022
Cholesterol determines the cytosolic entry and seeded aggregation of tau.
Cell reports
Tuck BJ,Miller LVC,Katsinelos T,Smith AE,Wilson EL,Keeling S,Cheng S,Vaysburd MJ,Knox C,Tredgett L,Metzakopian E,James LC,McEwan WA
MA5-15738 was used in Western Blotting to establish assays for the study of tau entry into the cytosol as a phenomenon distinct from uptake, in real time, and at physiological concentrations.
Tue May 03 00:00:00 EDT 2022
Combination of a STAT3 inhibitor with anti-PD-1 immunotherapy is an effective treatment regimen for a vemurafenib-resistant melanoma.
Molecular therapy oncolytics
Kim TW,Kim Y,Keum H,Jung W,Kang M,Jon S
MA5-15738 was used in Western Blotting to investigate the antitumor efficacy and TME remodeling by APTSTAT3-9R, a cell-permeable STAT3 inhibitory peptide, as a strategy to treat vemurafenib-resistant melanoma.
Thu Sep 15 00:00:00 EDT 2022
Robust anti-SARS-CoV2 single domain antibodies cross neutralize multiple viruses.
iScience
Singh S,Dahiya S,Singh YJ,Beeton K,Jain A,Sarkar R,Dubey A,Tehseen A,Sehrawat S
MA5-15738 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to report robust SARS-CoV2 neutralizing sdAbs targeting the viral peptides encompassing the polybasic cleavage site (CSP) and in the receptor binding domain (RBD) of the spike (S) protein.
Fri Jul 15 00:00:00 EDT 2022
Rational development of a combined mRNA vaccine against COVID-19 and influenza.
NPJ vaccines
Ye Q,Wu M,Zhou C,Lu X,Huang B,Zhang N,Zhao H,Chi H,Zhang X,Ling D,Zhang RR,Li Z,Luo D,Huang YJ,Qiu HY,Song H,Tan W,Xu K,Ying B,Qin CF
MA5-15738 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to highlight the potential of the LNP-mRNA vaccine platform in preventing COVID-19 and influenza, as well as other respiratory diseases.
Tue Jul 26 00:00:00 EDT 2022
Loss of Claudin-4 Reduces DNA Damage Repair and Increases Sensitivity to PARP Inhibitors.
Molecular cancer therapeutics
Yamamoto TM,Webb PG,Davis DM,Baumgartner HK,Woodruff ER,Guntupalli SR,Neville M,Behbakht K,Bitler BG
MA5-15738 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to highlight that claudin-4 expression in ovarian cancer tumors could serve as both a marker of PARP inhibitor response and a therapeutic target to improve PARP inhibitor response.
Fri Apr 01 00:00:00 EDT 2022
Risk SNP-mediated LINC01614 upregulation drives head and neck squamous cell carcinoma progression via PI3K/AKT signaling pathway.
Molecular carcinogenesis
Hou Y,Zhou M,Li Y,Tian T,Sun X,Chen M,Xu W,Lu M
MA5-15738 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to reveal that the risk SNP rs3113503 G > C in LINC01614 altered the binding to miR-616-3p, which led to increased LINC01614 expression and promoted HNSCC progression by activating the PI3K/AKT signaling pathway.
Mon Aug 01 00:00:00 EDT 2022
Trpm8 Expression in Human and Mouse Castration Resistant Prostate Adenocarcinoma Paves the Way for the Preclinical Development of TRPM8-Based Targeted Therapies.
Biomolecules
Genovesi S,Moro R,Vignoli B,De Felice D,Canossa M,Montironi R,Carbone FG,Barbareschi M,Lunardi A,Alaimo A
MA5-15738 was used in Western Blot to characterize the expression of the TRPM8 cation channel in both hormone naïve and castration resistant tumors.
Sun Jan 23 00:00:00 EST 2022
Trpm8 Expression in Human and Mouse Castration Resistant Prostate Adenocarcinoma Paves the Way for the Preclinical Development of TRPM8-Based Targeted Therapies.
Biomolecules
Genovesi S,Moro R,Vignoli B,De Felice D,Canossa M,Montironi R,Carbone FG,Barbareschi M,Lunardi A,Alaimo A
MA5-15738 was used in Western Blot to characterize the expression of the TRPM8 cation channel in both hormone naïve and castration resistant tumors.
Sun Jan 23 00:00:00 EST 2022
Fucoidan-Mediated Inhibition of Fibrotic Properties in Oral Submucous Fibrosis via the MEG3/miR-181a/Egr1 Axis.
Pharmaceuticals (Basel, Switzerland)
Fang CY,Chen SH,Huang CC,Liao YW,Chao SC,Yu CC
MA5-15738 was used in Western Blotting to investigate the anti-fibrotic effect of fucoidan on oral fibrosis.
Tue Jul 05 00:00:00 EDT 2022
Dynamic rewiring of biological activity across genotype and lineage revealed by context-dependent functional interactions.
Genome biology
Kim E,Novak LC,Lin C,Colic M,Bertolet LL,Gheorghe V,Bristow CA,Hart T
MA5-15738 was used in Western Blotting to decipher dynamic functional interactions by identifying significant cellular contexts, primarily by oncogenic mutation, lineage, and tumor type, and discovering coessentiality relationships that depend on these contexts.
Wed Jun 29 00:00:00 EDT 2022
Coapplication of Magnesium Supplementation and Vibration Modulate Macrophage Polarization to Attenuate Sarcopenic Muscle Atrophy through PI3K/Akt/mTOR Signaling Pathway.
International journal of molecular sciences
Cui C,Bao Z,Chow SK,Wong RMY,Welch A,Qin L,Cheung WH
MA5-15738 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to demonstrate that the PI3K/Akt/mTOR pathway is the predominant regulatory mechanism through which LMHFV and Mg enhanced muscle regeneration and suppressed atrogene upregulation.
Wed Oct 26 00:00:00 EDT 2022
Bioorthogonal site-selective conjugation of fluorescent dyes to antibodies: method and potential applications.
RSC advances
Grossenbacher P,Essers MC,Moser J,Singer SA,Häusler S,Stieger B,Rougier JS,Lochner M
MA5-15738 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to provide a practical method to site-specifically label native antibodies with bright fluorescent dyes by targeting the solvent-accessible interchain disulphide bonds.
Tue Oct 04 00:00:00 EDT 2022
Bioorthogonal site-selective conjugation of fluorescent dyes to antibodies: method and potential applications.
RSC advances
Grossenbacher P,Essers MC,Moser J,Singer SA,Häusler S,Stieger B,Rougier JS,Lochner M
MA5-15738 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to provide a practical method to site-specifically label native antibodies with bright fluorescent dyes by targeting the solvent-accessible interchain disulphide bonds.
Tue Oct 04 00:00:00 EDT 2022
Dengue virus downregulates TNFR1- and TLR3-stimulated NF-κB activation by targeting RIPK1.
Frontiers in cellular and infection microbiology
Udawatte DJ,Lang DM,Currier JR,Medin CL,Rothman AL
MA5-15738 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot, Immunoprecipitation to report that interaction of NS3 with RIPK1 results in the inhibition of NF-κB activation in response to TNFR or TLR3 stimulation, thus decreasing intracellular RIPK1 levels during DENV infection.
Thu Nov 03 00:00:00 EDT 2022
Dengue virus downregulates TNFR1- and TLR3-stimulated NF-κB activation by targeting RIPK1.
Frontiers in cellular and infection microbiology
Udawatte DJ,Lang DM,Currier JR,Medin CL,Rothman AL
MA5-15738 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot, Immunoprecipitation to report that interaction of NS3 with RIPK1 results in the inhibition of NF-κB activation in response to TNFR or TLR3 stimulation, thus decreasing intracellular RIPK1 levels during DENV infection.
Thu Nov 03 00:00:00 EDT 2022
The Parkinson's disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability.
Cell
Hallacli E,Kayatekin C,Nazeen S,Wang XH,Sheinkopf Z,Sathyakumar S,Sarkar S,Jiang X,Dong X,Di Maio R,Wang W,Keeney MT,Felsky D,Sandoe J,Vahdatshoar A,Udeshi ND,Mani DR,Carr SA,Lindquist S,De Jager PL,Bartel DP,Myers CL,Greenamyre JT,Feany MB,Sunyaev SR,Chung CY,Khurana V
MA5-15738 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to show that αS directly modulates processing bodies (P-bodies), membraneless organelles that function in mRNA turnover and storage.
Thu Jun 09 00:00:00 EDT 2022
DEAD box 1 (DDX1) protein binds to and protects cytoplasmic stress response mRNAs in cells exposed to oxidative stress.
The Journal of biological chemistry
Li L,Garg M,Wang Y,Wang W,Godbout R
MA5-15738 was used in Western Blotting to examine the role of DDX1 in response to environmental stress.
Mon Aug 01 00:00:00 EDT 2022
Reverting TP53 Mutation in Breast Cancer Cells: Prime Editing Workflow and Technical Considerations.
Cells
Abuhamad AY,Mohamad Zamberi NN,Sheen L,Naes SM,Mohd Yusuf SNH,Ahmad Tajudin A,Mohtar MA,Amir Hamzah AS,Syafruddin SE
MA5-15738 was used in Western Blotting to revert a TP53 missense mutation (L194F) in a T47D breast cancer cell line and introduce the same mutation in HEK293T cells.
Wed May 11 00:00:00 EDT 2022
A multi-functional role for the MCM8/9 helicase complex in maintaining fork integrity during replication stress.
Nature communications
Griffin WC,McKinzey DR,Klinzing KN,Baratam R,Eliyapura A,Trakselis MA
MA5-15738 was used in Western Blotting to define multifunctional roles for MCM8/9 in promoting normal replication fork progression and genome integrity following stress.
Tue Aug 30 00:00:00 EDT 2022
Prostate Apoptosis Response-4 (Par-4): A Novel Target in Pyronaridine-Induced Apoptosis in Glioblastoma (GBM) Cells.
Cancers
Ghosalkar J,Sonawane V,Pisal T,Achrekar S,Pujari R,Chugh A,Shastry P,Joshi K
MA5-15738 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot, In Vitro Assay to demonstrate for the first time that PYR can be repurposed against GBM with a novel mechanism of action involving Par-4.
Wed Jun 29 00:00:00 EDT 2022
The TLR-chaperone CNPY3 is a critical regulator of NLRP3-inflammasome activation.
European journal of immunology
Ghait M,Husain RA,Duduskar SN,Haack TB,Rooney M,Göhrig B,Bauer M,Rubio I,Deshmukh SD
MA5-15738 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to reveal a hitherto unknown, TLR-independent role of CNPY3 in inflammasome activation, highlighting a more complex and dedicated role of CNPY3 to the inflammatory response than anticipated.
Wed Jun 01 00:00:00 EDT 2022
Age-Induced Changes in μ-Opioid Receptor Signaling in the Midbrain Periaqueductal Gray of Male and Female Rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Fullerton EF,Karom MC,Streicher JM,Young LJ,Murphy AZ
MA5-15738 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to investigate the impact of advanced age and biological sex on opioid signaling in the ventrolateral periaqueductal gray (vlPAG) in the presence of chronic inflammatory pain.
Tue Jul 05 00:00:00 EDT 2022
Inhibition of CD146 attenuates retinal neovascularization via vascular endothelial growth factor receptor 2 signalling pathway in proliferative diabetic retinopathy.
Acta ophthalmologica
Lin J,Cui K,Xu Y,Tang X,Shi Y,Lu X,Yang B,He Q,Yu S,Liang X
MA5-15738 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to indicate that CD146 was involved in the development of retinal neovascularization via VEGFR2 pathway.
Wed Jun 01 00:00:00 EDT 2022
Effect of Combined Methamphetamine and Oxycodone Use on the Synaptic Proteome in an In Vitro Model of Polysubstance Use.
Genes
Meyer D,Athota P,Gowen A,Nguyen NM,Schaal VL,Yelamanchili SV,Pendyala G
MA5-15738 was used in Western Blotting to indicate several damaging effects of the combined use of METH and oxy on neural function and warrants further detailed investigation into mechanisms contributing to synaptic dysfunction.
Sat Oct 08 00:00:00 EDT 2022
Immunofluorescence Detection of Plasma Membranous PTEN in Cultured Cells.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Kato T
MA5-15738 was used in Western Blotting to show that live-cell imaging and appropriate immunofluorescence including a novel antigen retrieval treatment were both useful for detecting the cellular localization of PTEN, particularly at the plasma membrane.
Fri Apr 01 00:00:00 EDT 2022
Proteomic changes in broiler liver by body weight differences under chronic heat stress.
Poultry science
Park JS,Kang DR,Shim KS
MA5-15738 was used in Western Blotting to show that high temperature stress aggravated oxidative stress in broilers, which resulted in comparatively slow growth to preserve body homeostasis.
Sun May 01 00:00:00 EDT 2022
Modulation of MHC-E transport by viral decoy ligands is required for RhCMV/SIV vaccine efficacy.
Science (New York, N.Y.)
Verweij MC,Hansen SG,Iyer R,John N,Malouli D,Morrow D,Scholz I,Womack J,Abdulhaqq S,Gilbride RM,Hughes CM,Ventura AB,Ford JC,Selseth AN,Oswald K,Shoemaker R,Berkemeier B,Bosche WJ,Hull M,Shao J,Sacha JB,Axthelm MK,Edlefsen PT,Lifson JD,Picker LJ,Früh K
MA5-15738 was used in Western Blot to show Rh67-enabled direct priming of MHC-E-restricted T cells is crucial for RhCMV/SIV vaccine efficacy.
Fri Apr 30 00:00:00 EDT 2021
TNF-mediated alveolar macrophage necroptosis drives disease pathogenesis during respiratory syncytial virus infection.
The European respiratory journal
Santos LD,Antunes KH,Muraro SP,de Souza GF,da Silva AG,Felipe JS,Zanetti LC,Czepielewski RS,Magnus K,Scotta M,Mattiello R,Maito F,de Souza APD,Weinlich R,Vinolo MAR,Porto BN
MA5-15738 was used in Western Blotting to report that RSV infection triggers necroptosis in primary mouse macrophages and human monocytes in a RIPK1-, RIPK3-, and MLKL-dependent manner.
Tue Jun 01 00:00:00 EDT 2021
Dynamin deficiency causes insulin secretion failure and hyperglycemia.
Proceedings of the National Academy of Sciences of the United States of America
Fan F,Wu Y,Hara M,Rizk A,Ji C,Nerad D,Tamarina N,Lou X
MA5-15738 was used in Western Blot to investigate the process of endocytosis in mouse pancreatic B cells through the deletion of dyanamin GTPase.
Tue Aug 10 00:00:00 EDT 2021
Exosome-transmitted miRNA-335-5p promotes colorectal cancer invasion and metastasis by facilitating EMT via targeting RASA1.
Molecular therapy. Nucleic acids
Sun X,Lin F,Sun W,Zhu W,Fang D,Luo L,Li S,Zhang W,Jiang L
MA5-15738 was used in Western Blotting to find that exosomes derived from metastatic CRC cell line SW620 promoted migration, invasion, and epithelial-mesenchymal transition (EMT) of CRC cells.
Fri Jun 04 00:00:00 EDT 2021
The metalloproteinase ADAM10 requires its activity to sustain surface expression.
Cellular and molecular life sciences : CMLS
Seifert A,Düsterhöft S,Wozniak J,Koo CZ,Tomlinson MG,Nuti E,Rossello A,Cuffaro D,Yildiz D,Ludwig A
MA5-15738 was used in Western Blot to demonstrate that loss of proteolytic activity of ADAM10 by either inhibition or loss of function mutations induces removal of the protease from the cell surface and the whole cell.
Fri Jan 01 00:00:00 EST 2021
The metalloproteinase ADAM10 requires its activity to sustain surface expression.
Cellular and molecular life sciences : CMLS
Seifert A,Düsterhöft S,Wozniak J,Koo CZ,Tomlinson MG,Nuti E,Rossello A,Cuffaro D,Yildiz D,Ludwig A
MA5-15738 was used in Western Blot to demonstrate that loss of proteolytic activity of ADAM10 by either inhibition or loss of function mutations induces removal of the protease from the cell surface and the whole cell.
Fri Jan 01 00:00:00 EST 2021
Rapid degradation of GRASP55 and GRASP65 reveals their immediate impact on the Golgi structure.
The Journal of cell biology
Zhang Y,Seemann J
MA5-15738 was used in Immunocytochemistry to dissect the respective roles of GRASP55 and GRASP65 on golgi structure formation.
Mon Jan 04 00:00:00 EST 2021
The WAVE complex associates with sites of saddle membrane curvature.
The Journal of cell biology
Pipathsouk A,Brunetti RM,Town JP,Graziano BR,Breuer A,Pellett PA,Marchuk K,Tran NT,Krummel MF,Stamou D,Weiner OD
MA5-15738 was used in Western Blot to define organizing principles of the WAVE complex lamellipodial template and suggests how feedback between cell shape and actin regulators instructs cell morphogenesis.
Mon Aug 02 00:00:00 EDT 2021
Sterol and oxysterol synthases near the ciliary base activate the Hedgehog pathway.
The Journal of cell biology
Findakly S,Daggubati V,Garcia G,LaStella SA,Choudhury A,Tran C,Li A,Tong P,Garcia JQ,Puri N,Reiter JF,Xu L,Raleigh DR
MA5-15738 was used in Western Blot to identify an enzyme involved in lipid biosynthesis which acts as an activator of the Hedgehog pathway.
Mon Jan 04 00:00:00 EST 2021
Extracellular clusterin limits the uptake of α-synuclein fibrils by murine and human astrocytes.
Glia
Filippini A,Mutti V,Faustini G,Longhena F,Ramazzina I,Rizzi F,Kaganovich A,Roosen DA,Landeck N,Duffy M,Tessari I,Bono F,Fiorentini C,Greggio E,Bubacco L,Bellucci A,Missale M,Cookson MR,Gennarelli M,Russo I
MA5-15738 was used in Western Blotting to explore how clusterin affects the clearance of α-synuclein aggregates by astrocytes.
Mon Mar 01 00:00:00 EST 2021
The Axonal Glycolytic Pathway Contributes to Sensory Axon Extension and Growth Cone Dynamics.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ketschek A,Sainath R,Holland S,Gallo G
MA5-15738 was used in Immunocytochemistry to reveal that the glycolytic pathway is required for normal sensory axon extension in the presence of NGF, while in the absence of NGF the glycolytic pathway is required for axon maintenance, which indicates that NGF has protective effects on sensory axon maintenance in hypoglycemic states.
Wed Aug 04 00:00:00 EDT 2021
Long Noncoding RNA X-Inactive-Specific Transcript Promotes the Secretion of Inflammatory Cytokines in LPS Stimulated Astrocyte Cell Via Sponging miR-29c-3p and Regulating Nuclear Factor of Activated T cell 5 Expression.
Frontiers in endocrinology
Zhang M,Yang H,Chen Z,Hu X,Wu T,Liu W
MA5-15738 was used in Western Blotting to establish rat epilepsy model and lipopolysaccharide (LPS)-treated CTX-TNA2.
Tue Dec 21 00:00:00 EST 2021
Identification of Translocation Inhibitors Targeting the Type III Secretion System of Enteropathogenic Escherichia coli.
Antimicrobial agents and chemotherapy
Mühlen S,Zapol'skii VA,Bilitewski U,Dersch P
MA5-15738 was used in Western Blotting to show three new compounds that strongly inhibit T3SS-mediated translocation of effectors into mammalian cells, which could be valuable as lead substances for treating EPEC and enterohemorrhagic E. coli infections.
Wed Nov 17 00:00:00 EST 2021
β2-Adrenergic receptor agonist induced hepatic steatosis in mice: modeling nonalcoholic fatty liver disease in hyperadrenergic states.
American journal of physiology. Endocrinology and metabolism
Shi Y,Pizzini J,Wang H,Das F,Abdul Azees PA,Ghosh Choudhury G,Barnes JL,Zang M,Weintraub ST,Yeh CK,Katz MS,Kamat A
MA5-15738 was used in Western Blot to define the intrahepatic mechanisms underlying β2-AR mediated steatosis and the corresponding functional aspects in model nonalcoholic fatty liver disease livers.
Thu Jul 01 00:00:00 EDT 2021
ABPP-HT - High-Throughput Activity-Based Profiling of Deubiquitylating Enzyme Inhibitors in a Cellular Context.
Frontiers in chemistry
Jones HBL,Heilig R,Fischer R,Kessler BM,Pinto-Fernández A
MA5-15738 was used in Western Blotting to describe a new methodology named ABPP-HT (high-throughput-compatible activity-based protein profiling), implementing a semi-automated proteomic sample preparation workflow that increases the throughput capabilities of the classical ABPP workflow approximately ten times while preserving its enzyme profiling characteristics.
Sat Nov 11 00:00:00 EST 2023
Metabolic Adaptation of Macrophages as Mechanism of Defense against Crystalline Silica.
Journal of immunology (Baltimore, Md. : 1950)
Marrocco A,Frawley K,Pearce LL,Peterson J,O'Brien JP,Mullett SJ,Wendell SG,St Croix CM,Mischler SE,Ortiz LA
MA5-15738 was used in Western Blot to highlight the importance of complex II activity and tricarboxylic acid cycle remodeling to macrophage survival and cytokine-mediated inflammation in silicosis.
Wed Sep 15 00:00:00 EDT 2021
Cyclooxygenase-2 regulates PTHrP transcription in human articular chondrocytes and is involved in the pathophysiology of osteoarthritis in rats.
Journal of orthopaedic translation
Chang LH,Chen CH,Wu SC,Chang JK,Ho ML
MA5-15738 was used in Western Blot to conclude that COX2 up-regulates PTHrP expression in normal and OA articular chondrocytes.
Wed Sep 01 00:00:00 EDT 2021
Nuclear SR-protein mediated mRNA quality control is continued in cytoplasmic nonsense-mediated decay.
RNA biology
Grosse S,Lu YY,Coban I,Neumann B,Krebber H
MA5-15738 was used in Western Blot to show that Gbp2 and Hrb1 also function in nonsense mediated decay (NMD) of spliced premature termination codon (PTC)-containing mRNAs.
Fri Oct 01 00:00:00 EDT 2021
Deorphanizing Caspase-3 and Caspase-9 Substrates In and Out of Apoptosis with Deep Substrate Profiling.
ACS chemical biology
Araya LE,Soni IV,Hardy JA,Julien O
MA5-15738 was used in Western Blotting to suggest that in addition to its important role in activating the executioners, the role of caspase-9 is likely broader and more complex than previously appreciated, which includes proteolysis of key apoptotic substrates other than just caspase-3 and -7 and involvement in non-apoptotic pathways.
Fri Nov 19 00:00:00 EST 2021
Anastral Spindle 3/Rotatin Stabilizes Sol narae and Promotes Cell Survival in Drosophila melanogaster.
Molecules and cells
Cho DG,Lee SS,Cho KO
MA5-15738 was used in Western Blotting to report that ana3m19 is a suppressor of lethality induced by the overexpression of Sol narae (Sona), a metalloprotease in a disintegrin and metalloprotease with thrombospondin motif (ADAMTS) family.
Sun Jan 31 00:00:00 EST 2021
Nicotine abolishes memory-related synaptic strengthening and promotes synaptic depression in the neurogenic dentate gyrus of miR-132/212 knockout mice.
Addiction biology
Stojanovic T,Benes H,Awad A,Bormann D,Monje FJ
MA5-15738 was used in Western Blotting to examine the effects of miR-132/212 gene disruption on the levels of hippocampal nicotinic acetylcholine receptors, total ERK and phosphorylated ERK (pERK) and MeCP2 protein levels, and study the impact of nicotine stimulation on hippocampal synaptic transmission and synaptic depression and strengthening.
Mon Mar 01 00:00:00 EST 2021
A mouse model of Huntington's disease shows altered ultrastructure of transverse tubules in skeletal muscle fibers.
The Journal of general physiology
Romer SH,Metzger S,Peraza K,Wright MC,Jobe DS,Song LS,Rich MM,Foy BD,Talmadge RJ,Voss AA
MA5-15738 was used in Western Blot to explain dysregulated EC coupling and motor impairment in Huntington's disease.
Mon Apr 05 00:00:00 EDT 2021
Autophagy activation and photoreceptor survival in retinal detachment.
Experimental eye research
Xiao J,Yao J,Jia L,Ferguson TA,Weber S,Sundstrom JM,Wubben TJ,Besirli CG,Zacks DN
MA5-15738 was used in Western Blotting to assess the effect of autophagy inhibition on photoreceptor survival during experimental retinal detachment and examine the relationship between autophagy and the expression of glycolytic enzymes HK2 and PKM2 in the retina.
Thu Apr 01 00:00:00 EDT 2021
Prognostic significance of uPA and uPAR expression in patients with cervical cancer undergoing radiotherapy.
Oncology letters
Nantajit D,Chailapakul P,Bawornpatarapakorn S,Chamchod S,Laebua K
MA5-15738 was used in Western Blot to indicate that increased expression of uPAR in cervical tumor tissue during radiotherapy may serve as a prognostic marker for patients with cervical cancer.
Sat May 01 00:00:00 EDT 2021
Discovery of hydroxytyrosol as thioredoxin reductase 1 inhibitor to induce apoptosis and G1/S cell cycle arrest in human colorectal cancer cells via ROS generation.
Experimental and therapeutic medicine
Zhang SP,Zhou J,Fan QZ,Lv XM,Wang T,Wang F,Chen Y,Hong SY,Liu XP,Xu BS,Hu L,Zhang C,Zhang YM
MA5-15738 was used in Western Blot to investigate if the natural product hydroxytyrosol (HT), which exhibits a polyphenol scaffold, is a potent inhibitor of thioredoxin reductase 1.
Sun Aug 01 00:00:00 EDT 2021
Growth factors improve the proliferation of Jeju black pig muscle cells by regulating myogenic differentiation 1 and growth-related genes.
Animal bioscience
Park J,Lee J,Song KD,Kim SJ,Kim DC,Lee SC,Son YJ,Choi HW,Shim K
MA5-15738 was used in Western Blot to establish optimal culture conditions for Jeju black pig (JBP) muscle cells and determine the relationship of various factors involved in muscle growth with the proliferation of JBP muscle cells.
Sun Aug 01 00:00:00 EDT 2021
The autophagy protein Becn1 improves insulin sensitivity by promoting adiponectin secretion via exocyst binding.
Cell reports
Kuramoto K,Kim YJ,Hong JH,He C
MA5-15738 was used in Western Blot to demonstrate that Becn1 improves insulin sensitivity by facilitating adiponectin secretion through binding the exocyst in adipose tissue.
Tue May 25 00:00:00 EDT 2021
Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology.
eLife
Errington TM,Denis A,Allison AB,Araiza R,Aza-Blanc P,Bower LR,Campos J,Chu H,Denson S,Donham C,Harr K,Haven B,Iorns E,Kwok J,McDonald E,Pelech S,Perfito N,Pike A,Sampey D,Settles M,Scott DA,Sharma V,Tolentino T,Trinh A,Tsui R,Willis B,Wood J,Young L
MA5-15738 was used in Western Blot to report the status and outcomes obtained for the remaining 11 papers. Four papers initiated experimental work but were stopped without any experimental outcomes.
Tue Dec 07 00:00:00 EST 2021
Architecture and regulation of an enterobacterial cellulose secretion system.
Science advances
Abidi W,Zouhir S,Caleechurn M,Roche S,Krasteva PV
MA5-15738 was used in Western Blotting to present cryo-EM structures of the assembled Bcs macrocomplex, as well as multiple crystallographic snapshots of regulatory Bcs subcomplexes.
Fri Jan 01 00:00:00 EST 2021
Changes in Drp1 Function and Mitochondrial Morphology Are Associated with the α-Synuclein Pathology in a Transgenic Mouse Model of Parkinson's Disease.
Cells
Portz P,Lee MK
MA5-15738 was used in Western Blot to examine a mouse model of α-synucleinopathy for αS pathology-linked alterations in mitochondrial dynamics in vivo.
Tue Apr 13 00:00:00 EDT 2021
Metabolomic analysis of a selective ABCA1 inducer in obesogenic challenge provides a rationale for therapeutic development.
EBioMedicine
Lewandowski CT,Khan MW,BenAissa M,Dubrovskyi O,Ackerman-Berrier M,LaDu MJ,Layden BT,Thatcher GRJ
MA5-15738 was used in Western Blot to synthesize and characterize a novel small molecule for selective induction of ABCA1 vs.
Thu Apr 01 00:00:00 EDT 2021
Improved pyrrolysine biosynthesis through phage assisted non-continuous directed evolution of the complete pathway.
Nature communications
Ho JML,Miller CA,Smith KA,Mattia JR,Bennett MR
MA5-15738 was used in Western Blot to investigate if Alternating Phage Assisted Non-Continuous Evolution provides a general approach for evolving proteins exhibiting toxic side effects, and if it provides an improved pathway capable of producing substantially greater quantities of Pyl-proteins in E. coli.
Thu Jun 24 00:00:00 EDT 2021
Importin α phosphorylation promotes TPX2 activation by GM130 to control astral microtubules and spindle orientation.
Journal of cell science
Guo H,Wei JH,Zhang Y,Seemann J
MA5-15738 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to report that the spindle assembly factor TPX2 regulates astral microtubules and that the substrate preference of the important mitotic modulator importin α is regulated by CDK1-mediated phosphorylation.
Fri Feb 19 00:00:00 EST 2021
Importin α phosphorylation promotes TPX2 activation by GM130 to control astral microtubules and spindle orientation.
Journal of cell science
Guo H,Wei JH,Zhang Y,Seemann J
MA5-15738 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to report that the spindle assembly factor TPX2 regulates astral microtubules and that the substrate preference of the important mitotic modulator importin α is regulated by CDK1-mediated phosphorylation.
Fri Feb 19 00:00:00 EST 2021
Nuclear PTEN deficiency and heterozygous PTEN loss have distinct impacts on brain and lymph node size.
Biochemical and biophysical research communications
Igarashi A,Kato T,Sesaki H,Iijima M
MA5-15738 was used in Western Blotting to investigate the impact of a combination of heterozygous PTEN loss and nuclear PTEN loss on the size of various organs, including the brain, liver, thymus, spleen, and inguinal lymph node.
Fri May 28 00:00:00 EDT 2021
Development of a porcine model of phenylketonuria with a humanized R408W mutation for gene editing.
PloS one
Kaiser RA,Carlson DF,Allen KL,Webster DA,VanLith CJ,Nicolas CT,Hillin LG,Yu Y,Kaiser CW,Wahoff WR,Hickey RD,Watson AL,Winn SR,Thöny B,Kern DR,Harding CO,Lillegard JB
MA5-15738 was used in Western Blotting to develop and characterise pig model of Phenylketonuria.
Fri Jun 18 00:00:00 EDT 2021
Heterologous avian system for quantitative analysis of Syncytin-1 interaction with ASCT2 receptor.
Retrovirology
Štafl K,Trávníček M,Kučerová D,Pecnová Ľ,Krchlíková V,Gáliková E,Stepanets V,Hejnar J,Trejbalová K
MA5-15738 was used in Western Blot to present here a heterologous chicken system for effective assessment of the expression of transmembrane ASCT2 protein and its interaction with Syncytin-1.
Tue Jun 22 00:00:00 EDT 2021
Porin 1 Modulates Autophagy in Yeast.
Cells
Broeskamp F,Edrich ESM,Knittelfelder O,Neuhaus L,Meyer T,Heyden J,Habernig L,Kreppel F,Gourlay CW,Rockenfeller P
MA5-15738 was used in Western Blotting to show that POR1 deficiency is associated with reduced autophagy, which can be circumvented by additional PSD1 overexpression.
Tue Sep 14 00:00:00 EDT 2021
The uncharacterized protein FAM47E interacts with PRMT5 and regulates its functions.
Life science alliance
Chakrapani B,Khan MIK,Kadumuri RV,Gupta S,Verma M,Awasthi S,Govindaraju G,Mahesh A,Rajavelu A,Chavali S,Dhayalan A
MA5-15738 was used in Western Blotting to identify FAM47E as a protein regulator of PRMT5.
Mon Mar 01 00:00:00 EST 2021
Neutrophil stimulation with citrullinated histone H4 slows down calcium influx and reduces NET formation compared with native histone H4.
PloS one
Shi L,Aymonnier K,Wagner DD
MA5-15738 was used in Western Blotting to show that histone H4 can induce NET formation in a calcium and PAD4 dependent manner.
Tue Oct 19 00:00:00 EDT 2021
ClpX Is Essential and Activated by Single-Strand DNA Binding Protein in Mycobacteria.
Journal of bacteriology
Kester JC,Kandror O,Akopian T,Chase MR,Zhu J,Rubin EJ,Goldberg AL,Fortune SM
MA5-15738 was used in Western Blotting to demonstrate that a loss of ClpX is sufficient to interrupt DNA replication, suggesting the ClpX-SSB complex may play a role in DNA replication in mycobacteria.
Mon Jan 25 00:00:00 EST 2021
Unique Regulation of Intestinal Villus Epithelial Cl-/HCO3- Exchange by Cyclooxygenase Pathway Metabolites of Arachidonic Acid in a Mouse Model of Spontaneous Ileitis.
International journal of molecular sciences
Rahman MM,Borthakur A,Afroz S,Arthur S,Sundaram U
MA5-15738 was used in Western Blot to conclude that inhibition of villus cell Cl-/HCO3- exchange by COX pathway AAMs, such as prostaglandins, via reducing the affinity of the exchanger for Cl-, and thereby causing NaCl malabsorption, could significantly contribute to IBD-associated diarrhea.
Sat Apr 17 00:00:00 EDT 2021
A GRM7 mutation associated with developmental delay reduces mGlu7 expression and produces neurological phenotypes.
JCI insight
Fisher NM,AlHashim A,Buch AB,Badivuku H,Samman MM,Weiss KM,Cestero GI,Does MD,Rook JM,Lindsley CW,Conn PJ,Gogliotti RG,Niswender CM
MA5-15738 was used in Western Blot to present new clinical cases of 2 sisters with severe developmental delay and epilepsy confirmed to be homozygous for a GRM7 variant.
Mon Feb 22 00:00:00 EST 2021
A GRM7 mutation associated with developmental delay reduces mGlu7 expression and produces neurological phenotypes.
JCI insight
Fisher NM,AlHashim A,Buch AB,Badivuku H,Samman MM,Weiss KM,Cestero GI,Does MD,Rook JM,Lindsley CW,Conn PJ,Gogliotti RG,Niswender CM
MA5-15738 was used in Western Blot to present new clinical cases of 2 sisters with severe developmental delay and epilepsy confirmed to be homozygous for a GRM7 variant.
Mon Feb 22 00:00:00 EST 2021
Knockout of sodium channel Nax delays re-epithelializathion of splinted murine excisional wounds.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
Hou C,Dolivo D,Rodrigues A,Li Y,Leung K,Galiano R,Hong SJ,Mustoe T
MA5-15738 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to report development of a knockout mouse that lacks expression of functional Nax, and demonstrate that lack of functional Nax results in deficient wound healing in a murine splinted excisional wound healing model.
Mon Mar 01 00:00:00 EST 2021
Theileria annulata Subtelomere-Encoded Variable Secreted Protein-TA05575 Binds to Bovine RBMX2.
Frontiers in cellular and infection microbiology
Li Z,Liu J,Zhao S,Ma Q,Liu A,Li Y,Guan G,Luo J,Yin H
MA5-15738 was used in Western Blotting to suggest that TA05575 may contribute for cells transformation due its distribution.
Mon Jul 05 00:00:00 EDT 2021
Effect of Neprilysin Inhibition for Ischemic Mitral Regurgitation after Myocardial Injury.
International journal of molecular sciences
Lee S,Hwang HS,Song N,Kang GH,Choi KH,Ji E,Song JM,Kang DH
MA5-15738 was used in Western Blot to conclude that neprilysin inhibitor has positive effects on LV reverse remodeling and also attenuates fibrosis in MV leaflets and restores adaptive growth by directly modulating EndoMT.
Tue Aug 10 00:00:00 EDT 2021
Herpes Simplex Virus Type 1 Neuronal Infection Triggers the Disassembly of Key Structural Components of Dendritic Spines.
Frontiers in cellular neuroscience
Acuña-Hinrichsen F,Covarrubias-Pinto A,Ishizuka Y,Stolzenbach MF,Martin C,Salazar P,Castro MA,Bramham CR,Otth C
MA5-15738 was used in Immunocytochemistry to demonstrate that HSV-1 infection induces structural disassembly and functional deregulation in cultured cortical neurons, an altered glutamate response, Arc accumulation within the somata, and decreased expression of spine scaffolding-like proteins such as PSD-95, Drebrin and CaMKIIβ.
Sat Nov 11 00:00:00 EST 2023
Inhibition of the mTOR pathway and reprogramming of protein synthesis by MDM4 reduce ovarian cancer metastatic properties.
Cell death & disease
Lucà R,Assenza MR,Maiullari F,Pieroni L,Maiullari S,Federici G,Marini F,Rizzi R,Urbani A,Soddu S,Moretti F
MA5-15738 was used in Western Blot to demonstrate that MDM4 impairs EOC metastatic process by inhibiting mTOR activity and suggest the usefulness of MDM4 assessment for the tailored application of mTOR-targeted therapy.
Sat May 29 00:00:00 EDT 2021
Activating mGlu3 Metabotropic Glutamate Receptors Rescues Schizophrenia-like Cognitive Deficits Through Metaplastic Adaptations Within the Hippocampus.
Biological psychiatry
Dogra S,Stansley BJ,Xiang Z,Qian W,Gogliotti RG,Nicoletti F,Lindsley CW,Niswender CM,Joffe ME,Conn PJ
MA5-15738 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to demonstrate that activation of mGlu3 receptors in hippocampal pyramidal cells enhances hippocampal-dependent cognition in control and impaired mice by inducing a novel form of metaplasticity to regulate circuit function, providing a clear mechanism through which genetic variation in GRM3 can contribute to cognitive deficits.
Wed Sep 15 00:00:00 EDT 2021
Response of MCF-7 Breast Cancer Cells Overexpressed with P-Glycoprotein to Apoptotic Induction after Photodynamic Therapy.
Molecules (Basel, Switzerland)
Aniogo EC,George BP,Abrahamse H
MA5-15738 was used in Western Blotting to show the role of PDT in the treatment of a resistant phenotype breast cancer.
Mon Dec 06 00:00:00 EST 2021
GluA4 facilitates cerebellar expansion coding and enables associative memory formation.
eLife
Kita K,Albergaria C,Machado AS,Carey MR,Müller M,Delvendahl I
MA5-15738-1MG was used in Western Blotting to demonstrate an essential role for GluA4-containing AMPARs in cerebellar information processing and associative learning.
Mon Jul 05 00:00:00 EDT 2021
Whole exome sequencing identifies deleterious rare variants in CCDC141 in familial self-limited delayed puberty.
NPJ genomic medicine
Saengkaew T,Ruiz-Babot G,David A,Mancini A,Mariniello K,Cabrera CP,Barnes MR,Dunkel L,Guasti L,Howard SR
MA5-15738 was used in Western Blotting to discover important underlying regulators of self-limited delayed puberty through interrogation of GnRH pathways.
Mon Dec 20 00:00:00 EST 2021
Overexpressed GNA13 induces temozolomide sensitization via down-regulating MGMT and p-RELA in glioma.
American journal of translational research
Liu Y,Du Z,Xu Z,Jin T,Xu K,Huang M,Wang S,Zheng Y,Liu M,Xu H
MA5-15738 was used in Western Blotting to investigate whether the two signaling pathways, GNA13/PRKACA/p-RELA and GNA13/PRKACA/MGMT, were involved in the molecular mechanism of GNA13 in TMZ sensitization.
Thu Nov 18 00:00:00 EST 2021
Microelectromechanical System Measurement of Platelet Contraction: Direct Interrogation of Myosin Light Chain Phosphorylation.
International journal of molecular sciences
George MJ,Litvinov J,Aroom K,Spangler LJ,Caplan H,Wade CE,Cox CS,Gill BS
MA5-15738 was used in Western Blotting to investigate the relationship between platelet contraction force and MLC phosphorylation using a novel microelectromechanical (MEMS) based clot contraction sensor (CCS).
Wed Jun 16 00:00:00 EDT 2021
Silencing of Sphingosine kinase 1 Affects Maturation Pathways in Mouse Neonatal Cardiomyocytes.
International journal of molecular sciences
Jozefczuk E,Szczepaniak P,Guzik TJ,Siedlinski M
MA5-15738 was used in Western Blotting to demonstrate that the Sphk1 silencing in neonatal mouse CMs facilitated their postnatal maturation in both physiological and stress conditions.
Wed Mar 31 00:00:00 EDT 2021
Early heat exposure effect on the heat shock proteins in broilers under acute heat stress.
Poultry science
Kang D,Shim K
MA5-15738 was used in Western Blotting to investigate the effects of early heat conditioning on the acute heat stress response in broilers.
Mon Mar 01 00:00:00 EST 2021
Antibody-drug nanoparticle induces synergistic treatment efficacies in HER2 positive breast cancer cells.
Scientific reports
Abedin MR,Powers K,Aiardo R,Barua D,Barua S
MA5-15738 was used in Western Blot to engineer antibody-drug nanoparticles by synthesizing pure anti-cancer drug nanorods in the core of nanoparticles with a therapeutic monoclonal antibody.
Thu Apr 01 00:00:00 EDT 2021
Endoplasmic reticulum tubules limit the size of misfolded protein condensates.
eLife
Parashar S,Chidambaram R,Chen S,Liem CR,Griffis E,Lambert GG,Shaner NC,Wortham M,Hay JC,Ferro-Novick S
MA5-15738 was used in Western Blot to report that the COPII coat subunit, SEC24C, works with the long form of the tubular ER-phagy receptor, RTN3, to target dominant-interfering mutant proinsulin Akita puncta to lysosomes.
Wed Sep 01 00:00:00 EDT 2021
Generating a new mouse model for nuclear PTEN deficiency by a single K13R mutation.
Genes to cells : devoted to molecular & cellular mechanisms
Kato T,Igarashi A,Sesaki H,Iijima M
MA5-15738 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to demonstrate that PTENK13R mice provide a useful animal model to study the role of PTEN in the nucleus in vivo.
Wed Dec 01 00:00:00 EST 2021
Modulating HSF1 levels impacts expression of the estrogen receptor α and antiestrogen response.
Life science alliance
Silveira MA,Tav C,Bérube-Simard FA,Cuppens T,Leclercq M,Fournier É,Côté MC,Droit A,Bilodeau S
MA5-15738 was used in Western Blotting to show that high levels of the stress response master regulator, the heat shock factor 1 (HSF1), are associated with antiestrogen resistance in breast cancer cells.
Sat May 01 00:00:00 EDT 2021
Encapsulated VEGF121-PLA microparticles promote angiogenesis in human endometrium stromal cells.
Journal, genetic engineering & biotechnology
Abraham S,Sanjay G,Majiyd NA,Chinnaiah A
MA5-15738 was used in Western Blotting to investigate the migration, proliferation and the protein levels of human immortalized endometrium stromal cells after treating the cells with recombinant Vascular Endothelial Growth Factor (200 and 500 nanogram), and poly-l-lactide loaded Vascular Endothelial Growth Factor 121 (day 1, 20 and 30).
Mon Feb 01 00:00:00 EST 2021
Screening and identification of Theileria annulata subtelomere-encoded variable secreted protein-950454 (SVSP454) interacting proteins from bovine B cells.
Parasites & vectors
Li Z,Liu J,Ma Q,Liu A,Li Y,Guan G,Luo J,Yin H
MA5-15738 was used in Western Blot to speculate that SVSP454-CCDC181/SVSP454MRPL30 is an interacting axis that regulates the microtubule network and translation process of the host by some vital signaling molecules.
Fri Jun 11 00:00:00 EDT 2021
A homozygous stop-gain variant in ARHGAP42 is associated with childhood interstitial lung disease, systemic hypertension, and immunological findings.
PLoS genetics
Li Q,Dibus M,Casey A,Yee CSK,Vargas SO,Luo S,Rosen SM,Madden JA,Genetti CA,Brabek J,Brownstein CA,Kazerounian S,Raby BA,Schmitz-Abe K,Kennedy JC,Fishman MP,Mullen MP,Taylor JM,Rosel D,Agrawal PB
MA5-15738 was used in Western Blotting to describe an 8-year-old girl with childhood interstitial lung disease (chILD), systemic hypertension, and immunological findings who carries a homozygous stop-gain variant (c.469G>T, p.(Glu157Ter)) in the ARHGAP42 gene.
Thu Jul 01 00:00:00 EDT 2021
Pulsed-electromagnetic-field induced osteoblast differentiation requires activation of genes downstream of adenosine receptors A2A and A3.
PloS one
Kar NS,Ferguson D,Zhang N,Waldorff EI,Ryaby JT,DiDonato JA
MA5-15738 was used in Western Blotting to propose that there are complementary and parallel positive roles for adenosine receptor A2A and A3 in PEMF-mediated osteoblast differentiation.
Tue Aug 31 00:00:00 EDT 2021
Sirt1 coordinates with ERα to regulate autophagy and adiposity.
Cell death discovery
Tao Z,Shi L,Parke J,Zheng L,Gu W,Dong XC,Liu D,Wang Z,Olumi AF,Cheng Z
MA5-15738 was used in Western Blotting to show that the energy sensor Sirt1 mediates sex difference in adiposity by regulating autophagy and adipogenesis in partnership with estrogen receptor α (ERα).
Mon Mar 15 00:00:00 EDT 2021
Regulatory Function of Sympathetic Innervation on the Endo/Lysosomal Trafficking of Acetylcholine Receptor.
Frontiers in physiology
Straka T,Schröder C,Roos A,Kollipara L,Sickmann A,Williams MPI,Hafner M,Khan MM,Rudolf R
MA5-15738 was used in Western Blot to provide novel insights into the relevance of sympathetic innervation for the homeostasis of muscle and neuromuscular junctions.
Tue Mar 30 00:00:00 EDT 2021
Abraxas suppresses DNA end resection and limits break-induced replication by controlling SLX4/MUS81 chromatin loading in response to TOP1 inhibitor-induced DNA damage.
Nature communications
Wu X,Wang B
MA5-15738 was used in Western Blot to implicate Abraxas/BRCA1-A complex as a critical regulator that restrains BIR for protection of genome stability.
Fri Jul 16 00:00:00 EDT 2021
Synthetic dysmobility screen unveils an integrated STK40-YAP-MAPK system driving cell migration.
Science advances
Yu LY,Tseng TJ,Lin HC,Hsu CL,Lu TX,Tsai CJ,Lin YC,Chu I,Peng CT,Chen HJ,Tsai FC
MA5-15738 was used in Western Blot to unveil an integrated STK40-YAP-MAPK system regulating cell migration and introduced "synthetic dysmobility" as a novel strategy to collaboratively control cell migration.
Thu Jul 01 00:00:00 EDT 2021
Dyrk1a gene dosage in glutamatergic neurons has key effects in cognitive deficits observed in mouse models of MRD7 and Down syndrome.
PLoS genetics
Brault V,Nguyen TL,Flores-Gutiérrez J,Iacono G,Birling MC,Lalanne V,Meziane H,Manousopoulou A,Pavlovic G,Lindner L,Selloum M,Sorg T,Yu E,Garbis SD,Hérault Y
MA5-15738 was used in Western Blot, Immunoprecipitation to study whether the change in the dosage of Dyrk1a in glutamatergic neurons of the hippocampus and cortex of Down syndrome and MRD7 mouse models alter their development and/or normal working in adult brain, leading to the cognitive deficits observed in Down syndrome or Dyrk1a haploinsufficiency models.
Wed Sep 01 00:00:00 EDT 2021
Dyrk1a gene dosage in glutamatergic neurons has key effects in cognitive deficits observed in mouse models of MRD7 and Down syndrome.
PLoS genetics
Brault V,Nguyen TL,Flores-Gutiérrez J,Iacono G,Birling MC,Lalanne V,Meziane H,Manousopoulou A,Pavlovic G,Lindner L,Selloum M,Sorg T,Yu E,Garbis SD,Hérault Y
MA5-15738 was used in Western Blot, Immunoprecipitation to study whether the change in the dosage of Dyrk1a in glutamatergic neurons of the hippocampus and cortex of Down syndrome and MRD7 mouse models alter their development and/or normal working in adult brain, leading to the cognitive deficits observed in Down syndrome or Dyrk1a haploinsufficiency models.
Wed Sep 01 00:00:00 EDT 2021
Protein Digests and Pure Peptides from Chia Seed Prevented Adipogenesis and Inflammation by Inhibiting PPARγ and NF-κB Pathways in 3T3L-1 Adipocytes.
Nutrients
Grancieri M,Martino HSD,Gonzalez de Mejia E
MA5-15738 was used in Western Blotting to evaluate the mechanisms of digested total proteins (DTP), albumin, glutelin, and pure peptides from chia seed (Salvia hispanica L.) to prevent adipogenesis and its associated inflammation in 3T3-L1 adipocytes.
Fri Jan 08 00:00:00 EST 2021
Structure of the full-length human Pannexin1 channel and insights into its role in pyroptosis.
Cell discovery
Zhang S,Yuan B,Lam JH,Zhou J,Zhou X,Ramos-Mandujano G,Tian X,Liu Y,Han R,Li Y,Gao X,Li M,Yang M
MA5-15738 was used in Western Blotting to show that in human macrophages PANX1 expression is upregulated by diverse stimuli that promote pyroptosis, which is reminiscent of the previously reported lipopolysaccharide-induced upregulation of PANX1 during inflammasome activation.
Tue May 04 00:00:00 EDT 2021
Sensitive period for rescuing parvalbumin interneurons connectivity and social behavior deficits caused by TSC1 loss.
Nature communications
Amegandjin CA,Choudhury M,Jadhav V,Carriço JN,Quintal A,Berryer M,Snapyan M,Chattopadhyaya B,Saghatelyan A,Di Cristo G
MA5-15738 was used in Western Blot to explore the functional contribution of mTORC1 pathway regulation by Tsc1 in the development of parvalbumin interneurons and their relation to autism pathology.
Wed Jun 16 00:00:00 EDT 2021
Therapeutic Benefit of Galectin-1: Beyond Membrane Repair, a Multifaceted Approach to LGMD2B.
Cells
Vallecillo-Zúniga ML,Poulson PD,Luddington JS,Arnold CJ,Rathgeber M,Kartchner BC,Hayes S,Gill H,Valdoz JC,Spallino JL,Garfield S,Dodson EL,Arthur CM,Stowell SR,Van Ry PM
MA5-15738 was used in Western Blot, Immunocytochemistry to demonstrate that the reduced dimeric form of Gal-1 is responsible for inducing improvements to muscle membrane repair, while the monomeric form is responsible for changes in inflammation.
Wed Nov 17 00:00:00 EST 2021
Therapeutic Benefit of Galectin-1: Beyond Membrane Repair, a Multifaceted Approach to LGMD2B.
Cells
Vallecillo-Zúniga ML,Poulson PD,Luddington JS,Arnold CJ,Rathgeber M,Kartchner BC,Hayes S,Gill H,Valdoz JC,Spallino JL,Garfield S,Dodson EL,Arthur CM,Stowell SR,Van Ry PM
MA5-15738 was used in Western Blot, Immunocytochemistry to demonstrate that the reduced dimeric form of Gal-1 is responsible for inducing improvements to muscle membrane repair, while the monomeric form is responsible for changes in inflammation.
Wed Nov 17 00:00:00 EST 2021
Tra2beta-Dependent Regulation of RIO Kinase 3 Splicing During Rift Valley Fever Virus Infection Underscores the Links Between Alternative Splicing and Innate Antiviral Immunity.
Frontiers in cellular and infection microbiology
White LA,Bisom TC,Grimes HL,Hayashi M,Lanchy JM,Lodmell JS
MA5-15738 was used in Western Blot to identify splicing factor TRA2-β (also known as TRA2beta and hTRA2-β) as a key regulator governing the relative abundance of splicing isoforms of RIOK3, a protein involved in the cellular immune response to viral infection.
Tue Apr 05 00:00:00 EDT 2022
Endosomal traffic and glutamate synapse activity are increased in VPS35 D620N mutant knock-in mouse neurons, and resistant to LRRK2 kinase inhibition.
Molecular brain
Kadgien CA,Kamesh A,Milnerwood AJ
MA5-15738 was used in Western Blot to demonstrate the VPS35 mutation has effects that are independent of ongoing LRRK2 kinase activity, and that LRRK2 kinase inhibition alters basal physiology of glutamate synapses in vitro.
Thu Sep 16 00:00:00 EDT 2021
Changes in microtubule stability in zebrafish (Danio rerio) embryos after glyphosate exposure.
Heliyon
Díaz-Martín RD,Valencia-Hernández JD,Betancourt-Lozano M,Yáñez-Rivera B
MA5-15738 was used in Western Blot to suggest a possible toxicity mechanism for this herbicide related to changes in microtubule stability, which could alter the distribution and dynamics of cytoskeleton components.
Fri Jan 01 00:00:00 EST 2021
XCT 790 is a pharmacological aggrephagy inducer in a yeast model of proteotoxicity.
Cell biology international
Suresh SN,Jayaprakash Rao M,Manjithaya R
MA5-15738 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to show that XCT 790 clears toxic α-synuclein aggregates in an autophagy-dependent manner.
Mon Mar 01 00:00:00 EST 2021
USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma.
eLife
Ruiz EJ,Pinto-Fernandez A,Turnbull AP,Lan L,Charlton TM,Scott HC,Damianou A,Vere G,Riising EM,Da Costa C,Krajewski WW,Guerin D,Kearns JD,Ioannidis S,Katz M,McKinnon C,O'Connell J,Moncaut N,Rosewell I,Nye E,Jones N,Heride C,Gersch M,Wu M,Dinsmore CJ,Hammonds TR,Kim S,Komander D,Urbe S,Clague MJ,Kessler BM,Behrens A
MA5-15738 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to conclude that USP28 may represent a promising therapeutic target for the treatment of squamous cell lung carcinoma.
Tue Oct 12 00:00:00 EDT 2021
A Dominant Heterozygous Mutation in COG4 Causes Saul-Wilson Syndrome, a Primordial Dwarfism, and Disrupts Zebrafish Development via Wnt Signaling.
Frontiers in cell and developmental biology
Xia ZJ,Zeng XI,Tambe M,Ng BG,Dong PDS,Freeze HH
MA5-15738 was used in Western Blotting to understand the molecular mechanism of specific aspects of the Saul-Wilson syndrome phenotype.
Fri Jan 19 00:00:00 EST 2024
Robust Expression of Functional NMDA Receptors in Human Induced Pluripotent Stem Cell-Derived Neuronal Cultures Using an Accelerated Protocol.
Frontiers in molecular neuroscience
Ruden JB,Dixit M,Zepeda JC,Grueter BA,Dugan LL
MA5-15738 was used in Western Blotting to demonstrate that the mature neurons express functional NMDARs exhibiting ligand-activated calcium flux, and we document the presence of NMDAR-mediated electrically evoked postsynaptic current.
Tue Mar 15 00:00:00 EDT 2022
Cell Lineage-Based Stratification for Glioblastoma.
Cancer cell
Wang Z,Sun D,Chen YJ,Xie X,Shi Y,Tabar V,Brennan CW,Bale TA,Jayewickreme CD,Laks DR,Alcantara Llaguno S,Parada LF
MA5-15738 was used in Western blot to investigate the importance of cell lineage in glioblastoma independent of driver mutations and detail a methodology for functional glioblastoma classification for future clinical investigations.
Mon Sep 14 00:00:00 EDT 2020
Filgotinib suppresses HIV-1-driven gene transcription by inhibiting HIV-1 splicing and T cell activation.
The Journal of clinical investigation
Yeh YJ,Jenike KM,Calvi RM,Chiarella J,Hoh R,Deeks SG,Ho YC
MA5-15738 was used in Western Blotting to identify HIV-1-suppressing agents that can inhibit HIV-1 reactivation and reduce HIV-1-induced immune activation.
Tue Sep 01 00:00:00 EDT 2020
A Dimeric Structural Scaffold for PRC2-PCL Targeting to CpG Island Chromatin.
Molecular cell
Chen S,Jiao L,Liu X,Yang X,Liu X
MA5-15738 was used in Western Blot to report the crystal structure of a SUZ12-RBBP4 complex bound to fragments of the accessory subunits PHF19 and JARID2.
Thu Mar 19 00:00:00 EDT 2020
A Dimeric Structural Scaffold for PRC2-PCL Targeting to CpG Island Chromatin.
Molecular cell
Chen S,Jiao L,Liu X,Yang X,Liu X
MA5-15738 was used in Western Blot to report the crystal structure of a SUZ12-RBBP4 complex bound to fragments of the accessory subunits PHF19 and JARID2.
Thu Mar 19 00:00:00 EDT 2020
Post-translational modifications of hnRNP A1 differentially modulate retroviral IRES-mediated translation initiation.
Nucleic acids research
Barrera A,Ramos H,Vera-Otarola J,Fernández-García L,Angulo J,Olguín V,Pino K,Mouland AJ,López-Lastra M
MA5-15738 was used in Western Blotting to show that hnRNP A1 is also an ITAF for the HTLV-1 and MMTV IRESs.
Fri Oct 09 00:00:00 EDT 2020
Defective Sec61α1 underlies a novel cause of autosomal dominant severe congenital neutropenia.
The Journal of allergy and clinical immunology
Van Nieuwenhove E,Barber JS,Neumann J,Smeets E,Willemsen M,Pasciuto E,Prezzemolo T,Lagou V,Seldeslachts L,Malengier-Devlies B,Metzemaekers M,Haßdenteufel S,Kerstens A,van der Kant R,Rousseau F,Schymkowitz J,Di Marino D,Lang S,Zimmermann R,Schlenner S,Munck S,Proost P,Matthys P,Devalck C,Boeckx N,Claessens F,Wouters C,Humblet-Baron S,Meyts I,Liston A
MA5-15738 was used in Western Blotting to identify a novel de novo missense mutation in SEC61A1 (c.A275G;p.Q92R) in a patient with SCN who was born to nonconsanguineous Belgian parents.
Sun Nov 01 00:00:00 EDT 2020
Oncogenic Signaling Alters Cell Shape and Mechanics to Facilitate Cell Division under Confinement.
Developmental cell
Matthews HK,Ganguli S,Plak K,Taubenberger AV,Win Z,Williamson M,Piel M,Guck J,Baum B
MA5-15738 was used in Western Blot to investigate the effect of oncogene activation on the process of normal epithelial cell diving into tissue.
Mon Mar 09 00:00:00 EDT 2020
SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence.
Autophagy
Salazar G,Cullen A,Huang J,Zhao Y,Serino A,Hilenski L,Patrushev N,Forouzandeh F,Hwang HS
MA5-15738 was used in Western Blot to investigate the role of the mitochondrial regulator PPARGC1A and SQSTM1/p62 in autophagy and senescence.
Mon Jun 01 00:00:00 EDT 2020
Set1/COMPASS repels heterochromatin invasion at euchromatic sites by disrupting Suv39/Clr4 activity and nucleosome stability.
Genes & development
Greenstein RA,Barrales RR,Sanchez NA,Bisanz JE,Braun S,Al-Sady B
MA5-15738 was used in Western Blotting to show the inhibition of Suv39/Clr4-mediated catalysis and local disruption of nucleosome stability by H3K4 methylation antagonizes heterochromatin invasion at euchromatic sites.
Wed Jan 01 00:00:00 EST 2020
A partially disordered region connects gene repression and activation functions of EZH2.
Proceedings of the National Academy of Sciences of the United States of America
Jiao L,Shubbar M,Yang X,Zhang Q,Chen S,Wu Q,Chen Z,Rizo J,Liu X
MA5-15738 was used in Western Blotting to show that EZH2 harbors a hidden, partially disordered transactivation domain (TAD) capable of interacting with components of active transcription machinery, mimicking archetypal acidic activators.
Tue Jul 21 00:00:00 EDT 2020
Shear Stress Regulation of Endothelial Glycocalyx Structure Is Determined by Glucobiosynthesis.
Arteriosclerosis, thrombosis, and vascular biology
Wang G,Kostidis S,Tiemeier GL,Sol WMPJ,de Vries MR,Giera M,Carmeliet P,van den Berg BM,Rabelink TJ
MA5-15738 was used in Western Blotting to show that biosynthesis of the major structural component of the endothelial glycocalyx, hyaluronan, is regulated by shear.
Sat Feb 01 00:00:00 EST 2020
LINC00460-miR-149-5p/miR-150-5p-Mutant p53 Feedback Loop Promotes Oxaliplatin Resistance in Colorectal Cancer.
Molecular therapy. Nucleic acids
Meng X,Sun W,Yu J,Zhou Y,Gu Y,Han J,Zhou L,Jiang X,Wang C
MA5-15738 was used in Western Blotting to uncover a mechanism for the LINC00460-miR-149-5p/miR-150-5p-mutant p53 feedback loop in oxaliplatin resistance of CRC, and they provide potential therapeutic targets for tumor chemoresistance.
Fri Dec 04 00:00:00 EST 2020
Inhibition of Hsp90 in the spinal cord enhances the antinociceptive effects of morphine by activating an ERK-RSK pathway.
Science signaling
Duron DI,Lei W,Barker NK,Stine C,Mishra S,Blagg BSJ,Langlais PR,Streicher JM
MA5-15738 was used in Western Blot to investigate the effect of inhibiting Hsp90 on the spinal cord of mice.
Tue May 05 00:00:00 EDT 2020
Temporal activation of WNT/β-catenin signaling is sufficient to inhibit SOX10 expression and block melanoma growth.
Oncogene
Uka R,Britschgi C,Krättli A,Matter C,Mihic D,Okoniewski MJ,Gualandi M,Stupp R,Cinelli P,Dummer R,Levesque MP,Shakhova O
MA5-15738 was used in Western Blotting to show that MEK and RAF inhibitors do not suppress levels of SOX10 protein in patient-derived cells in vitro, as well as in melanoma patients in vivo.
Fri May 01 00:00:00 EDT 2020
DNA methylation and histone acetylation changes to cytochrome P450 2E1 regulation in normal aging and impact on rates of drug metabolism in the liver.
GeroScience
Kronfol MM,Jahr FM,Dozmorov MG,Phansalkar PS,Xie LY,Aberg KA,McRae M,Price ET,Slattum PW,Gerk PM,McClay JL
MA5-15738 was used in Western Blotting to investigate functional changes of cytochrome P450 2E1 (CYP2E1) gene with age in the liver.
Mon Jun 01 00:00:00 EDT 2020
RovC - a novel type of hexameric transcriptional activator promoting type VI secretion gene expression.
PLoS pathogens
Knittel V,Sadana P,Seekircher S,Stolle AS,Körner B,Volk M,Jeffries CM,Svergun DI,Heroven AK,Scrima A,Dersch P
MA5-15738 was used in Western Blotting to show hexameric transcription factor RovC promotes expression of the T6SS.
Tue Sep 01 00:00:00 EDT 2020
The Andes Orthohantavirus NSs Protein Antagonizes the Type I Interferon Response by Inhibiting MAVS Signaling.
Journal of virology
Vera-Otarola J,Solis L,Lowy F,Olguín V,Angulo J,Pino K,Tischler ND,Otth C,Padula P,López-Lastra M
MA5-15738 was used in Western Blotting to reveal new insights into the molecular regulation of the hosts' innate immune response by the Andes orthohantavirus.
Tue Jun 16 00:00:00 EDT 2020
miR-29a Is Repressed by MYC in Pancreatic Cancer and Its Restoration Drives Tumor-Suppressive Effects via Downregulation of LOXL2.
Molecular cancer research : MCR
Dey S,Kwon JJ,Liu S,Hodge GA,Taleb S,Zimmers TA,Wan J,Kota J
MA5-15738 was used in Western Blotting to show that in PDAC, repression of miR-29a is directly mediated by MYC via promoter activity.
Sat Feb 01 00:00:00 EST 2020
Doxorubicin Conjugation to Reovirus Improves Oncolytic Efficacy in Triple-Negative Breast Cancer.
Molecular therapy oncolytics
Berry JTL,Muñoz LE,Rodríguez Stewart RM,Selvaraj P,Mainou BA
MA5-15738 was used in Western Blotting to conjugated doxorubicin to reovirus (reo-dox) to control drug delivery and enhance reovirus-mediated oncolysis in Triple-Negative Breath Cancer.
Fri Sep 25 00:00:00 EDT 2020
Striated Preferentially Expressed Protein Kinase (SPEG)-Deficient Skeletal Muscles Display Fewer Satellite Cells with Reduced Proliferation and Delayed Differentiation.
The American journal of pathology
Li Q,Lin J,Rosen SM,Zhang T,Kazerounian S,Luo S,Agrawal PB
MA5-15738 was used in Western Blot to reveal specific abnormalities in myogenic cell number and behavior associated with SPEG deficiency.
Tue Dec 01 00:00:00 EST 2020
MicroRNA-33b Suppresses Epithelial-Mesenchymal Transition Repressing the MYC-EZH2 Pathway in HER2+ Breast Carcinoma.
Frontiers in oncology
Pattanayak B,Garrido-Cano I,Adam-Artigues A,Tormo E,Pineda B,Cabello P,Alonso E,Bermejo B,Hernando C,Martínez MT,Rovira A,Albanell J,Rojo F,Burgués O,Cejalvo JM,Lluch A,Eroles P
MA5-15738 was used in Western Blotting to suggest miR-33b as a suppressive miRNA that could inhibit tumor metastasis and invasion in HER2+ BC partly by impeding EMT through the repression of the MYC-EZH2 loop.
Tue Oct 06 00:00:00 EDT 2020
NVP-CGM097, an HDM2 Inhibitor, Antagonizes ATP-Binding Cassette Subfamily B Member 1-Mediated Drug Resistance.
Frontiers in oncology
Zhang M,Chen XY,Dong XD,Wang JQ,Feng W,Teng QX,Cui Q,Li J,Li XQ,Chen ZS
MA5-15738 was used in Western Blotting to evaluate whether NVP-CGM097 could reverse ABCB1-mediated MDR.
Mon Sep 28 00:00:00 EDT 2020
Alterations of signaling pathways in response to chemical perturbations used to measure mRNA decay rates in yeast.
RNA (New York, N.Y.)
Eshleman N,Luo X,Capaldi A,Buchan JR
MA5-15738 was used in Western Blotting to focus on common strategies to measure mRNA half-lives in yeast.
Wed Jan 01 00:00:00 EST 2020
Bacteria elevate extracellular adenosine to exploit host signaling for blood-brain barrier disruption.
Virulence
Zhao Z,Shang X,Chen Y,Zheng Y,Huang W,Jiang H,Lv Q,Kong D,Jiang Y,Liu P
MA5-15738 was used in Western Blotting to show that adenosine from a surface enzyme (Ssads) of Streptococcus suis facilitates this pathogen's entry into mouse brains.
Tue Dec 01 00:00:00 EST 2020
Local Targeting of Lung-Tumor-Associated Macrophages with Pulmonary Delivery of a CSF-1R Inhibitor for the Treatment of Breast Cancer Lung Metastases.
Molecular pharmaceutics
Alhudaithi SS,Almuqbil RM,Zhang H,Bielski ER,Du W,Sunbul FS,Bos PD,da Rocha SRP
MA5-15738 was used in Western Blot to demonstrate that pulmonary delivery of PLX-3397 is capable of overcoming the lung cancer tumour microenvironment, decrease phosphorylation of CSF-1 and increase M1 macrophage phenotypes.
Mon Dec 07 00:00:00 EST 2020
Schizosaccharomyces pombe DNA translocases Rrp1 and Rrp2 have distinct roles at centromeres and telomeres that ensure genome stability.
Journal of cell science
Barg-Wojas A,Muraszko J,Kramarz K,Schirmeisen K,Baranowska G,Carr AM,Dziadkowiec D
MA5-15738 was used in Western Blot to identify roles for Rrp1 and Rrp2 in maintaining centromere function by modulating histone dynamics, contributing to the preservation of genome stability during vegetative cell growth.
Mon Feb 10 00:00:00 EST 2020
Promoting roles of long non-coding RNA FAM83H-AS1 in bladder cancer growth, metastasis, and angiogenesis through the c-Myc-mediated ULK3 upregulation.
Cell cycle (Georgetown, Tex.)
Liu B,Gao W,Sun W,Li L,Wang C,Yang X,Liu J,Guo Y
MA5-15738 was used in Immunohistochemistry (Paraffin), Western Blot to demonstrate that FAM83H-AS1 upregulates ULK3 expression through the transcription factor c-Myc and promotes the progression of BCa.
Tue Dec 01 00:00:00 EST 2020
Promoting roles of long non-coding RNA FAM83H-AS1 in bladder cancer growth, metastasis, and angiogenesis through the c-Myc-mediated ULK3 upregulation.
Cell cycle (Georgetown, Tex.)
Liu B,Gao W,Sun W,Li L,Wang C,Yang X,Liu J,Guo Y
MA5-15738 was used in Immunohistochemistry (Paraffin), Western Blot to demonstrate that FAM83H-AS1 upregulates ULK3 expression through the transcription factor c-Myc and promotes the progression of BCa.
Tue Dec 01 00:00:00 EST 2020
Age-dependent changes in electrophysiology and calcium handling: implications for pediatric cardiac research.
American journal of physiology. Heart and circulatory physiology
Swift LM,Burke M,Guerrelli D,Reilly M,Ramadan M,McCullough D,Prudencio T,Mulvany C,Chaluvadi A,Jaimes R,Posnack NG
MA5-15738 was used in Protein Assays and Analysis to serve as a comprehensive baseline for future studies focused on pediatric disease modeling and/or preclinical testing.
Sat Feb 01 00:00:00 EST 2020
Progressive cardiac arrhythmias and ECG abnormalities in the Huntington's disease BACHD mouse model.
Human molecular genetics
Zhu Y,Shamblin I,Rodriguez E,Salzer GE,Araysi L,Margolies KA,Halade GV,Litovsky SH,Pogwizd S,Gray M,Huke S
MA5-15738 was used in Western Blotting to indicate that Huntingtin (mHTT) could cause progressive cardiac conduction system pathology that could increase the susceptibility to arrhythmias and sudden cardiac death in Huntington's disease (HD) patients.
Sat Feb 01 00:00:00 EST 2020
Cdc48/VCP and Endocytosis Regulate TDP-43 and FUS Toxicity and Turnover.
Molecular and cellular biology
Liu G,Byrd A,Warner AN,Pei F,Basha E,Buchanan A,Buchan JR
MA5-15738 was used in Western Blotting to discover a role for Cdc48/VCP in regulating the toxicity and turnover of TDP-43 and FUS in amyotrophic lateral sclerosis.
Thu Jan 30 00:00:00 EST 2020
Cyclin F is involved in response to cisplatin treatment in melanoma cell lines.
Oncology reports
Krajewski A,Gagat M,Żuryń A,Hałas-Wiśniewska M,Grzanka D,Grzanka A
MA5-15738 was used in Western Blot to investigate the difference between cyclin F expression in cell lines derived from primary and metastatic melanoma, A375 and RPMI‚7951.
Sun Mar 01 00:00:00 EST 2020
A1 adenosine receptor signaling reduces Streptococcus pneumoniae adherence to pulmonary epithelial cells by targeting expression of platelet-activating factor receptor.
Cellular microbiology
Bhalla M,Hui Yeoh J,Lamneck C,Herring SE,Tchalla EYI,Heinzinger LR,Leong JM,Bou Ghanem EN
MA5-15738 was used in Western Blotting to explore whether extracellular adenosine can directly impact bacterial adherence to lung epithelial cells.
Sat Feb 01 00:00:00 EST 2020
Transcriptome analysis of neural progenitor cells derived from Lowe syndrome induced pluripotent stem cells: identification of candidate genes for the neurodevelopmental and eye manifestations.
Journal of neurodevelopmental disorders
Liu H,Barnes J,Pedrosa E,Herman NS,Salas F,Wang P,Zheng D,Lachman HM
MA5-15738 was used in Western Blotting to investigate underlying mechanisms for neurodevelopmental and eye problems seen in Lowe syndrome patients.
Mon May 11 00:00:00 EDT 2020
Steroid synthesis and metabolism in the equine placenta during placentitis.
Reproduction (Cambridge, England)
El-Sheikh Ali H,Legacki EL,Scoggin KE,Loux SC,Dini P,Esteller-Vico A,Conley AJ,Stanley SD,Ball BA
MA5-15738 was used in Western Blotting to aim to elucidate the molecular mechanisms related to steroidogenesis and steroid-receptor signaling in the equine placenta during acute placentitis.
Sun Mar 01 00:00:00 EST 2020
Isolation and Characterization of primary human trabecular meshwork cells from segmental flow regions: New tools for understanding segmental flow.
Experimental eye research
Staverosky J,Dhamodaran K,Acott T,Raghunathan V,Vranka J
MA5-15738 was used in Western Blot to on the same genetic background.
Sat Aug 01 00:00:00 EDT 2020
Structure-based design, synthesis, and evaluation of the biological activity of novel phosphoroorganic small molecule IAP antagonists.
Investigational new drugs
Łupicka-Słowik A,Psurski M,Grzywa R,Cuprych M,Ciekot J,Goldeman W,Wojaczyńska E,Wojaczyński J,Oleksyszyn J,Sieńczyk M
MA5-15738 was used in Western Blotting to examine the antiproliferative potential as well as their proapoptotic action, manifested by an increase in caspase-3 activity.
Thu Oct 01 00:00:00 EDT 2020
CircRNA CDR1as knockdown inhibits progression of non-small-cell lung cancer by regulating miR-219a-5p/SOX5 axis.
Thoracic cancer
Li Y,Zhang J,Pan S,Zhou J,Diao X,Liu S
MA5-15738 was used in Western Blotting to investigate the mechanism by which circCDR1as mediates the development of NSCLC.
Sun Mar 01 00:00:00 EST 2020
A simple DMSO-based method for cryopreservation of primary hippocampal and cortical neurons.
Journal of neuroscience methods
Ishizuka Y,Bramham CR
MA5-15738 was used in Western Blot to present a simplified cryopreservation method for rodent primary hippocampal and cortical neurons from embryonic day 18.5 fetuses, using DMSO-containing traditional cell freezing medium.
Sun Mar 01 00:00:00 EST 2020
Synthesis of SMT022357 enantiomers and in vivo evaluation in a Duchenne muscular dystrophy mouse model.
Tetrahedron
Babbs A,Berg A,Chatzopoulou M,Davies KE,Davies SG,Edwards B,Elsey DJ,Emer E,Figuccia ALA,Fletcher AM,Guiraud S,Harriman S,Moir L,Robinson N,Rowley JA,Russell AJ,Squire SE,Thomson JE,Tinsley JM,Wilson FX,Wynne GM
MA5-15738 was used in Western Blotting to report the synthesis of SMT022357, a second generation utrophin modulator preclinical candidate, and an asymmetric synthesis of its constituent enantiomers.
Fri Jan 10 00:00:00 EST 2020
A Novel Approach to Deliver Therapeutic Extracellular Vesicles Directly into the Mouse Kidney via Its Arterial Blood Supply.
Cells
Ullah M,Liu DD,Rai S,Razavi M,Choi J,Wang J,Concepcion W,Thakor AS
MA5-15738 was used in Quantitative reverse transcription PCR to develop in mice a reproducible microsurgical technique for the delivery of therapeutics directly into each kidney, via its arterial blood supply.
Fri Apr 10 00:00:00 EDT 2020
Zinc Finger RNA-Binding Protein Zn72D Regulates ADAR-Mediated RNA Editing in Neurons.
Cell reports
Sapiro AL,Freund EC,Restrepo L,Qiao HH,Bhate A,Li Q,Ni JQ,Mosca TJ,Li JB
MA5-15738 was used in Western Blotting to show that Zn72D's regulatory role in RNA editing is conserved because the mammalian homolog of Zn72D, Zfr, regulates editing in mouse primary neurons.
Tue May 19 00:00:00 EDT 2020
Mechanism and Function of Antiviral RNA Interference in Mice.
mBio
Han Q,Chen G,Wang J,Jee D,Li WX,Lai EC,Ding SW
MA5-15738 was used in Western Blotting to characterise antiviral RNAi in a mouse model of infection with Nodamura virus (NoV), a mosquito-transmissible positive-strand RNA virus encoding a known double-stranded RNA (dsRNA)-binding viral suppressor of RNAi (VSR), the B2 protein.
Tue Aug 04 00:00:00 EDT 2020
Sustained Inflammatory Signalling through Stat1/Stat2/IRF9 Is Associated with Amoeboid Phenotype of Melanoma Cells.
Cancers
Gandalovičová A,Šůchová AM,Čermák V,Merta L,Rösel D,Brábek J
MA5-15738 was used in Western Blotting to report that cells after mesenchymal-amoeboid transition show the increased expression of genes associated with the type I interferon response.
Fri Aug 28 00:00:00 EDT 2020
Expressing a Z-disk nebulin fragment in nebulin-deficient mouse muscle: effects on muscle structure and function.
Skeletal muscle
Li F,Kolb J,Crudele J,Tonino P,Hourani Z,Smith JE,Chamberlain JS,Granzier H
MA5-15738 was used in Western Blot to reveal that nebulin fragments are well-received by nebulin-deficient mouse muscles and that limited functional benefits are achievable.
Tue Jan 28 00:00:00 EST 2020
Global targetome analysis reveals critical role of miR-29a in pancreatic stellate cell mediated regulation of PDAC tumor microenvironment.
BMC cancer
Dey S,Liu S,Factora TD,Taleb S,Riverahernandez P,Udari L,Zhong X,Wan J,Kota J
MA5-15738 was used in Western Blotting to study miR-29a's role in regulation of pancreatic stellate cells and essentially pathways associated with PDAC pathogenesis in cancer.
Mon Jul 13 00:00:00 EDT 2020
Deletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration.
Nature communications
Fragola G,Mabb AM,Taylor-Blake B,Niehaus JK,Chronister WD,Mao H,Simon JM,Yuan H,Li Z,McConnell MJ,Zylka MJ
MA5-15738 was used in Western Blotting to evaluate how loss of Top1 affected neurons in vivo.
Thu Apr 23 00:00:00 EDT 2020
High-throughput transcriptomic and proteomic profiling of mesenchymal-amoeboid transition in 3D collagen.
Scientific data
Čermák V,Gandalovičová A,Merta L,Harant K,Rösel D,Brábek J
MA5-15738 was used in Western Blotting to study the plasticity of cancer cell invasion.
Wed May 27 00:00:00 EDT 2020
Rdh54/Tid1 inhibits Rad51-Rad54-mediated D-loop formation and limits D-loop length.
eLife
Shah SS,Hartono S,Piazza A,Som V,Wright W,Chédin F,Heyer WD
MA5-15738 was used in Western Blotting to propose that Rdh54/Tid1 and Rad54 compete for potential binding sites within the Rad51 filament, where Rdh54/Tid1 acts as a physical roadblock to Rad54 translocation, limiting D-loop formation and D-loop length.
Fri Nov 13 00:00:00 EST 2020
Drp1 Tubulates the ER in a GTPase-Independent Manner.
Molecular cell
Adachi Y,Kato T,Yamada T,Murata D,Arai K,Stahelin RV,Chan DC,Iijima M,Sesaki H
MA5-15738 was used in Western Blot to find that Drp1 functions as a two-in-one protein during mitochondrial division, with ER tubulation and mechano-GTPase activities.
Thu Nov 19 00:00:00 EST 2020
Fibroblast-Derived STC-1 Modulates Tumor-Associated Macrophages and Lung Adenocarcinoma Development.
Cell reports
Kamata T,So TY,Ahmed Q,Giblett S,Patel B,Luo J,Reddel R,Pritchard C
MA5-15738 was used in Western Blotting to identify the pleiotropic glycoprotein stanniocalcin-1 (STC1) as a regulator of TAM-TAF interactions.
Tue Jun 23 00:00:00 EDT 2020
The dynamic interplay between ATP/ADP levels and autophagy sustain neuronal migration in vivo.
eLife
Bressan C,Pecora A,Gagnon D,Snapyan M,Labrecque S,De Koninck P,Parent M,Saghatelyan A
MA5-15738 was used in Western Blotting to show that autophagy and energy consumption act in concert in migrating cells to dynamically regulate the pace and periodicity of the migratory and stationary phases to sustain neuronal migration.
Mon Sep 28 00:00:00 EDT 2020
Discoidin Domain Receptor 1 Regulates Runx2 during Osteogenesis of Osteoblasts and Promotes Bone Ossification via Phosphorylation of p38.
International journal of molecular sciences
Chou LY,Chen CH,Chuang SC,Cheng TL,Lin YH,Chou HC,Fu YC,Wang YH,Wang CZ
MA5-15738 was used in Western Blotting to demonstrate that DDR1 mediates the expression and activity of Runx2 and the downstream osteogenesis markers during osteogenesis through regulation of p38 phosphorylation.
Tue Sep 29 00:00:00 EDT 2020
Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes.
Cell reports
Feyen DAM,McKeithan WL,Bruyneel AAN,Spiering S,Hörmann L,Ulmer B,Zhang H,Briganti F,Schweizer M,Hegyi B,Liao Z,Pölönen RP,Ginsburg KS,Lam CK,Serrano R,Wahlquist C,Kreymerman A,Vu M,Amatya PL,Behrens CS,Ranjbarvaziri S,Maas RGC,Greenhaw M,Bernstein D,Wu JC,Bers DM,Eschenhagen T,Metallo CM,Mercola M
MA5-15738 was used in Western Blotting to describe maturation media designed to provide oxidative substrates adapted to the metabolic needs of human iPSC (hiPSC)-CMs.
Tue Jul 21 00:00:00 EDT 2020
Oncogenic ALK drives tumorigenesis in cutaneous squamous cell carcinoma.
Life science alliance
Gualandi M,Iorio M,Engeler O,Serra-Roma A,Gasparre G,Schulte JH,Hohl D,Shakhova O
MA5-15738 was used in Western Blot to demonstrate that anaplastic lymphoma kinase (ALK), a receptor tyrosine kinase of the insulin receptor superfamily, plays a pivotal role in the pathogenesis of cSCC.
Mon Jun 01 00:00:00 EDT 2020
VEGF Treatment Ameliorates Depression-Like Behavior in Adult Offspring After Maternal Immune Activation.
Cells
Sideromenos S,Lindtner C,Zambon A,Horvath O,Berger A,Pollak DD
MA5-15738 was used in Western Blotting to conclude that VEGF administration, at the dosage tested, beneficially affects some aspects of the depression-like phenotype in the adult MIA offspring, inviting further studies using different dosage regimes to further explore the therapeutic potential of VEGF treatment in MIA-related changes in brain function and behavior.
Wed Apr 22 00:00:00 EDT 2020
Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation.
Nature communications
Gaub A,Sheikh BN,Basilicata MF,Vincent M,Nizon M,Colson C,Bird MJ,Bradner JE,Thevenon J,Boutros M,Akhtar A
MA5-15738 was used in Western Blotting to characterise a recruitment hierarchy, where Non-Specific Lethal (NSL)-deposited histone acetylation enables BRD4 recruitment for transcription of constitutively active genes.
Thu May 07 00:00:00 EDT 2020
Treatment with galectin-1 improves myogenic potential and membrane repair in dysferlin-deficient models.
PloS one
Vallecillo-Zúniga ML,Rathgeber MF,Poulson PD,Hayes S,Luddington JS,Gill HN,Teynor M,Kartchner BC,Valdoz J,Stowell C,Markham AR,Arthur C,Stowell S,Van Ry PM
MA5-15738 was used in Western Blotting to reveal Gal-1 mediates disease pathologies through both changes in integral myogenic protein expression and mechanical membrane stabilization.
Tue Oct 27 00:00:00 EDT 2020
CircZFR functions as a sponge of miR-578 to promote breast cancer progression by regulating HIF1A expression.
Cancer cell international
Chen Z,Wang F,Xiong Y,Wang N,Gu Y,Qiu X
MA5-15738 was used in Western Blotting to provide evidence for the crucial involvement of circZFR in BC pathogenesis.
Sun Nov 12 00:00:00 EST 2023
Insulin-like Growth Factor-1 and mTORC1 Signaling Promote the Intestinal Regenerative Response After Irradiation Injury.
Cellular and molecular gastroenterology and hepatology
Bohin N,McGowan KP,Keeley TM,Carlson EA,Yan KS,Samuelson LC
MA5-15738 was used in Western Blotting to assess the role of insulin-like growth factor-1 (IGF-1) to activate facultative stem cells for crypt repair.
Mon Nov 22 00:00:00 EST 2021
A Novel CD147 Inhibitor, SP-8356, Attenuates Pathological Fibrosis in Alkali-Burned Rat Cornea.
International journal of molecular sciences
Joung C,Noh H,Jung J,Song HY,Bae H,Pahk K,Kim WK
MA5-15738 was used in Western Blotting to examine the therapeutic efficacy of novel CD147 inhibiting verbenone derivative SP-8356 ((1S,5R)-4-(3,4-dihydroxy-5-methoxystyryl)-6,6-dimethylbicyclo[3.1.1]hept-3-en-2-one) on corneal fibrosis.
Thu Apr 23 00:00:00 EDT 2020
SOX4 promotes the growth and metastasis of breast cancer.
Cancer cell international
Zhang J,Xiao C,Feng Z,Gong Y,Sun B,Li Z,Lu Y,Fei X,Wu W,Sun X,Teng L
MA5-15738 was used in Western Blotting to investigate the role of SOX4 in the growth and metastasis in breast cancer and the underlying mechanism.
Sun Apr 17 00:00:00 EDT 2022
Arf1-mediated lipid metabolism sustains cancer cells and its ablation induces anti-tumor immune responses in mice.
Nature communications
Wang G,Xu J,Zhao J,Yin W,Liu D,Chen W,Hou SX
MA5-15738 was used in Western Blotting to reveal that Arf1-pathway knockdown not only kills cancer stem cells (CSCs) but also elicits a tumor-specific immune response that converts dying CSCs into a therapeutic vaccine, leading to durable benefits.
Fri Jan 10 00:00:00 EST 2020
CGGBP1-regulated cytosine methylation at CTCF-binding motifs resists stochasticity.
BMC genetics
Patel M,Patel D,Datta S,Singh U
MA5-15738 was used in Western Blotting to investigate how CGGBP1 effects cytosine methylation and CTCF occupancy.
Wed Jul 29 00:00:00 EDT 2020
Mucin-2 knockout is a model of intercellular junction defects, mitochondrial damage and ATP depletion in the intestinal epithelium.
Scientific reports
Borisova MA,Achasova KM,Morozova KN,Andreyeva EN,Litvinova EA,Ogienko AA,Morozova MV,Berkaeva MB,Kiseleva E,Kozhevnikova EN
MA5-15738 was used in Western Blotting to demonstrate the increased intestinal permeability and morphological defects in intercellular junctions in Muc2 knockout mice.
Thu Dec 03 00:00:00 EST 2020
Rrp6 Moonlights in an RNA Exosome-Independent Manner to Promote Cell Survival and Gene Expression during Stress.
Cell reports
Wang C,Liu Y,DeMario SM,Mandric I,Gonzalez-Figueroa C,Chanfreau GF
MA5-15738 was used in Western Blotting to demonstrate that Rrp6p moonlights independently from the exosome to ensure proper expression of CWI genes and to promote cell survival during stress.
Tue Jun 09 00:00:00 EDT 2020
Increased Level of Long Non-Coding RNA MALAT1 is a Common Feature of Amoeboid Invasion.
Cancers
Merta L,Gandalovičová A,Čermák V,Dibus M,Gutschner T,Diederichs S,Rösel D,Brábek J
MA5-15738 was used in Western Blot to address the role of MALAT1 in MAT/AMT (mesenchymal to amoeboid transition/amoeboid to mesenchymal transition) and suggests that increased MALAT1 expression is a common feature of amoeboid cells.
Fri May 01 00:00:00 EDT 2020
Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification.
Nature communications
Santos MCFD,Anderson CP,Neschen S,Zumbrennen-Bullough KB,Romney SJ,Kahle-Stephan M,Rathkolb B,Gailus-Durner V,Fuchs H,Wolf E,Rozman J,de Angelis MH,Cai WM,Rajan M,Hu J,Dedon PC,Leibold EA
MA5-15738 was used in Western Blot to reveal a previously unidentified link between insulin processing and cellular iron deficiency that may have relevance to type 2 diabetes in humans.
Wed Jan 15 00:00:00 EST 2020
Adrenoceptor Expression during Intervertebral Disc Degeneration.
International journal of molecular sciences
Kupka J,Kohler A,El Bagdadi K,Bostelmann R,Brenneis M,Fleege C,Chan D,Zaucke F,Meurer A,Rickert M,Jenei-Lanzl Z
MA5-15738 was used in Western Blotting to demonstrate the existence and functionality of adrenoceptors (ARs) in intervertebral disc (IVD) tissue samples.
Wed Mar 18 00:00:00 EDT 2020
The RNA quality control pathway nonsense-mediated mRNA decay targets cellular and viral RNAs to restrict KSHV.
Nature communications
Zhao Y,Ye X,Shehata M,Dunker W,Xie Z,Karijolich J
MA5-15738 was used in Western Blotting to demonstrate that NMD restricts KSHV lytic reactivation.
Fri Jul 03 00:00:00 EDT 2020
Involvement of Differentially Expressed microRNAs in the PEGylated Liposome Encapsulated 188Rhenium-Mediated Suppression of Orthotopic Hypopharyngeal Tumor.
Molecules (Basel, Switzerland)
Lin BZ,Wan SY,Lin MY,Chang CH,Chen TW,Yang MH,Lee YJ
MA5-15738 was used in Western Blotting to treat orthotopic HPC tumors and analyze the deregulated microRNA expressive profiles.
Sat Aug 08 00:00:00 EDT 2020
PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism.
Cell stem cell
Stine RR,Sakers AP,TeSlaa T,Kissig M,Stine ZE,Kwon CW,Cheng L,Lim HW,Kaestner KH,Rabinowitz JD,Seale P
MA5-15738 was used in Western Blotting to identify how PRDM16 regulates intestinal metabolism and epithelial renewal in a region-specific way.
Thu Dec 05 00:00:00 EST 2019
Reversible Disruption of Specific Transcription Factor-DNA Interactions Using CRISPR/Cas9.
Molecular cell
Shariati SA,Dominguez A,Xie S,Wernig M,Qi LS,Skotheim JM
MA5-15738 was used in Western Blotting to study the use of deactivated Cas9 to disrupt binding to specific sites.
Thu May 02 00:00:00 EDT 2019
Disruption of RPGR protein interaction network is the common feature of RPGR missense variations that cause XLRP.
Proceedings of the National Academy of Sciences of the United States of America
Zhang Q,Giacalone JC,Searby C,Stone EM,Tucker BA,Sheffield VC
MA5-15738 was used in Western Blot to validate the potential pathogenicity of RPGR missense variants.
Tue Jan 22 00:00:00 EST 2019
Loss of methionine sulfoxide reductases increases resistance to oxidative stress.
Free radical biology & medicine
Lai L,Sun J,Tarafdar S,Liu C,Murphy E,Kim G,Levine RL
MA5-15738 was used in Western Blotting to study the relationship between methionine sulfoxide reductases and oxidative stress in mice.
Sun Dec 01 00:00:00 EST 2019
Coxiella burnetii Type 4B Secretion System-dependent manipulation of endolysosomal maturation is required for bacterial growth.
PLoS pathogens
Samanta D,Clemente TM,Schuler BE,Gilk SD
MA5-15738 was used in Western Blotting to suggest that C. burnetii inhibits endosomal maturation to reduce the number of proteolytically active lysosomes available for heterotypic fusion with the CCV, possibly as a mechanism to regulate CCV pH.
Sun Dec 01 00:00:00 EST 2019
Influenza virus polymerase subunits co-evolve to ensure proper levels of dimerization of the heterotrimer.
PLoS pathogens
Chen KY,Santos Afonso ED,Enouf V,Isel C,Naffakh N
MA5-15738 was used in Western Blot to point to influenza polymerase dimerization as a feature that is controlled by a complex interplay of genetic determinants, can restrict genetic reassortment, and could become a target for antiviral drug development.
Tue Oct 01 00:00:00 EDT 2019
Chia (Salvia hispanica L.) Seed Total Protein and Protein Fractions Digests Reduce Biomarkers of Inflammation and Atherosclerosis in Macrophages In Vitro.
Molecular nutrition & food research
Grancieri M,Martino HSD,Gonzalez de Mejia E
MA5-15738 was used in Western Blot to evaluate the anti-inflammatory and anti-atherosclerotic effects of digested total protein and digested protein fractions from chia seed in macrophages in vitro.
Tue Oct 01 00:00:00 EDT 2019
Zika Virus Production Is Resistant to RNase L Antiviral Activity.
Journal of virology
Whelan JN,Li Y,Silverman RH,Weiss SR
MA5-15738 was used in Western Blotting to elucidate a unique mechanism whereby ZIKV production is impervious to antiviral RNase L activity.
Thu Aug 15 00:00:00 EDT 2019
Enhanced Killing of Triple-Negative Breast Cancer Cells by Reassortant Reovirus and Topoisomerase Inhibitors.
Journal of virology
Rodríguez Stewart RM,Berry JTL,Berger AK,Yoon SB,Hirsch AL,Guberman JA,Patel NB,Tharp GK,Bosinger SE,Mainou BA
MA5-15738 was used in Western Blotting to suggest that a combination of a genetically engineered oncolytic reovirus and topoisomerase inhibitors may provide a potent therapeutic option for patients afflicted with triple-negative breast cancer.
Sun Dec 01 00:00:00 EST 2019
The Influence of Pro-Inflammatory Factors on Sclerostin and Dickkopf-1 Production in Human Dental Pulp Cells Under Hypoxic Conditions.
Frontiers in bioengineering and biotechnology
Janjić K,Samiei M,Moritz A,Agis H
MA5-15738 was used in Western Blotting to assess if pro-inflammatory molecules have an influence on Sost and Dkk-1 production in dental pulp cells (DPC) under normoxia and hypoxia.
Thu Oct 01 00:00:00 EDT 2020
Structural Basis for Recruitment of DAPK1 to the KLHL20 E3 Ligase.
Structure (London, England : 1993)
Chen Z,Picaud S,Filippakopoulos P,D'Angiolella V,Bullock AN
MA5-15738 was used in Western Blotting to show a LPDLV-containing motif in the DAPK1 that mediates recruitment to KLHL20 E3 ligase for degradation.
Tue Sep 03 00:00:00 EDT 2019
Knockout of the X-linked Fgf13 in the hypothalamic paraventricular nucleus impairs sympathetic output to brown fat and causes obesity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Sinden DS,Holman CD,Bare CJ,Sun X,Gade AR,Cohen DE,Pitt GS
MA5-15738 was used in Western Blotting to suggest that impaired CNS regulation of sympathetic activation of brown fat underlies obesity and thermogenesis in Fgf13 heterozygous knockouts fed normal chow.
Tue Oct 01 00:00:00 EDT 2019
Glesatinib, a c-MET/SMO Dual Inhibitor, Antagonizes P-glycoprotein Mediated Multidrug Resistance in Cancer Cells.
Frontiers in oncology
Cui Q,Cai CY,Gao HL,Ren L,Ji N,Gupta P,Yang Y,Shukla S,Ambudkar SV,Yang DH,Chen ZS
MA5-15738 was used in Western Blotting to study the reversal effects of glesatinib to P-glycoprotein mediated multi-drug resistance.
Thu Oct 01 00:00:00 EDT 2020
Midostaurin Reverses ABCB1-Mediated Multidrug Resistance, an in vitro Study.
Frontiers in oncology
Ji N,Yang Y,Cai CY,Wang JQ,Lei ZN,Wu ZX,Cui Q,Yang DH,Chen ZS,Kong D
MA5-15738 was used in Western Blotting to find that midostaurin can antagonise ATP-binding cassette subfamily B member 1-mediated multidrug resistance.
Wed Sep 30 00:00:00 EDT 2020
A Study into the ADP-Ribosylome of IFN-γ-Stimulated THP-1 Human Macrophage-like Cells Identifies ARTD8/PARP14 and ARTD9/PARP9 ADP-Ribosylation.
Journal of proteome research
Higashi H,Maejima T,Lee LH,Yamazaki Y,Hottiger MO,Singh SA,Aikawa M
MA5-15738 was used in Western Blotting to identify interferon-γ-induced ADP-ribosylation substrates in macrophages.
Fri Apr 05 00:00:00 EDT 2019
MicroRNA-421-targeted PDCD4 regulates breast cancer cell proliferation.
International journal of molecular medicine
Wang Y,Liu Z,Shen J
MA5-15738 was used in Western Blotting to suggest a correlation between miR-421 and PDCD4, and physiological functions of breast cancer cells.
Tue Jan 01 00:00:00 EST 2019
Novel Therapeutic Anti-ADAM17 Antibody A9(B8) Enhances EGFR-TKI-Mediated Anticancer Activity in NSCLC.
Translational oncology
Yang Z,Chan KI,Kwok HF,Tam KY
MA5-15738 was used in Western Blot to suggest that targeting ADAM17 could potentiate the anticancer effects of EGFR-TKI against NSCLC and overcome drug resistance due to EGFR mutations.
Fri Nov 01 00:00:00 EDT 2019
Development of a Molecularly Stable Gene Therapy Vector for the Treatment of RPGR-Associated X-Linked Retinitis Pigmentosa.
Human gene therapy
Giacalone JC,Andorf JL,Zhang Q,Burnight ER,Ochoa D,Reutzel AJ,Collins MM,Sheffield VC,Mullins RF,Han IC,Stone EM,Tucker BA
MA5-15738 was used in Western Blot to generate a stable RPGR gene transfer vector capable of producing functional RPGR protein.
Thu Aug 01 00:00:00 EDT 2019
Enhanced Activity by NKCC1 and Slc26a6 Mediates Acidic pH and Cl- Movement after Cardioplegia-Induced Arrest of db/db Diabetic Heart.
Mediators of inflammation
Ji M,In Lee S,Lee SA,Son KH,Hong JH
MA5-15738 was used in Western Blot to suggest that enhanced Cl- influx and HCO3 - efflux through NKCC1 and Slc26a6 offer more acidic circumstances in the diabetic heart after cardioplegic arrest.
Mon Mar 23 00:00:00 EDT 2020
miR-98 Modulates Cytokine Production from Human PBMCs in Systemic Lupus Erythematosus by Targeting IL-6 mRNA.
Journal of immunology research
Yuan S,Tang C,Chen D,Li F,Huang M,Ye J,He Z,Li W,Chen Y,Lin X,Wang X,Cai X
MA5-15738 was used in Western Blotting to show miR-98 in systemic lupus erythematosus can target IL-6 mRNA to regulate cytokine production from peripheral blood mononuclear cells.
Mon May 18 00:00:00 EDT 2020
Therapeutic Effects of Nrf2 Activation by Bardoxolone Methyl in Chronic Heart Failure.
The Journal of pharmacology and experimental therapeutics
Tian C,Gao L,Zhang A,Hackfort BT,Zucker IH
MA5-15738 was used in Western Blotting to investigate the beneficial hemodynamic effects of bardoxolone methyl (2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid methyl ester, CDDO-Me), a pharmacological activator of nuclear factor (erythroid-derived 2)-like 2(Nrf2), in a rodent model of chronic heart failure(CHF).
Sun Dec 01 00:00:00 EST 2019
Role of forward and reverse signaling in Eph receptor and ephrin mediated cell segregation.
Experimental cell research
Wu Z,Ashlin TG,Xu Q,Wilkinson DG
MA5-15738 was used in Western Blot to propose that although polarised forward signaling is the principal driver of segregation, reverse signaling enables bidirectional repulsion which prevents mingling of each population into the other.
Thu Aug 01 00:00:00 EDT 2019
Angiopoietin-like 4 production upon treatment with hypoxia and L-mimosine in periodontal fibroblasts.
Journal of periodontal research
Janjić K,Schellner A,Engenhart A,Kernstock K,Schädl B,Moritz A,Agis H
MA5-15738 was used in Western Blotting to determine the role of angiopoietin-like 4 in peridontal tissue.
Tue Oct 01 00:00:00 EDT 2019
Placental Expression of NEMO Protein in Normal Pregnancy and Preeclampsia.
Disease markers
Sakowicz A,Lisowska M,Biesiada L,Płuciennik E,Gach A,Rybak-Krzyszkowska M,Huras H,Sakowicz B,Romanowicz H,Piastowska-Ciesielska AW,Grzesiak M,Pietrucha T
MA5-15738 was used in Western Blotting to examine the level and localisation of the NEMO protein in preeclamptic and nonpreeclamptic placentas.
Wed May 29 00:00:00 EDT 2019
Molecular imaging of endothelial activation and mineralization in a mouse model of accelerated atherosclerosis.
EJNMMI research
Rucher G,Cameliere L,Fendri J,Anfray A,Abbas A,Kamel S,Dupas Q,Delcroix N,Berger L,Manrique A
MA5-15738 was used in Western Blotting to study atherosclerosis and to report an active and sustained mineralization process compared to Ctl mice using [18F]NaF PET imaging.
Thu Aug 22 00:00:00 EDT 2019
Peri-adolescent alcohol consumption increases sensitivity and dopaminergic response to nicotine during adulthood in female alcohol-preferring (P) rats: Alterations to α7 nicotinic acetylcholine receptor expression.
Behavioural brain research
Waeiss RA,Knight CP,Carvajal GB,Bell RL,Engleman EA,McBride WJ,Hauser SR,Rodd ZA
MA5-15738 was used in Western Blotting to suggests that peri-adolescent EtOH consumption produced cross-sensitization to the effects of nicotine during adulthood.
Mon Dec 30 00:00:00 EST 2019
OBG-like ATPase 1 inhibition attenuates angiotensin II-induced hypertrophic response in human ventricular myocytes via GSK-3beta/beta-catenin signalling.
Clinical and experimental pharmacology & physiology
Narasimhan G,Henderson J,Luong HT,Rajasekaran NS,Qin G,Zhang J,Krishnamurthy P
MA5-15738 was used in Western Blotting to investigate the mechanism of OLA1 regulation of GSK3ß-ß Catenin signalling.
Thu Aug 01 00:00:00 EDT 2019
High LET Radiation Overcomes In Vitro Resistance to X-Rays of Chondrosarcoma Cell Lines.
Technology in cancer research & treatment
Chevalier F,Hamdi DH,Lepleux C,Temelie M,Nicol A,Austry JB,Lesueur P,Vares G,Savu D,Nakajima T,Saintigny Y
MA5-15738 was used in Western Blotting to demonstrate that irradiation with C-ions on chondrosarcoma cell lines was more efficient at killing them compared to general X-rays.
Tue Jan 01 00:00:00 EST 2019
Role and mechanism of nursing cooperation and tetramethylpyrazine application in post-operative pain in patients undergoing total knee arthroplasty.
Experimental and therapeutic medicine
Liu C,Liu R,Tang M,Yang X,Gong X
MA5-15738 was used in Western Blotting to investigate the effect of nursing cooperation on the post-operative complication of pain following total knee arthroplasty (TKA) and to explore the effects of tetramethylpyrazine application on post-TKA pain.
Fri Mar 01 00:00:00 EST 2019
Inhibition of MYC by the SMARCB1 tumor suppressor.
Nature communications
Weissmiller AM,Wang J,Lorey SL,Howard GC,Martinez E,Liu Q,Tansey WP
MA5-15738 was used in Western Blotting to examine the relationship between MYC and SNF5 using biochemical and genome-wide approaches.
Wed May 01 00:00:00 EDT 2019
Deacetylation Inhibition Reverses PABPN1-Dependent Muscle Wasting.
iScience
Olie CS,Riaz M,Konietzny R,Charles PD,Pinto-Fernandez A,Kiełbasa SM,Aartsma-Rus A,Goeman JJ,Kessler BM,Raz V
MA5-15738 was used in Western Blotting to elucidate the molecular mechanisms causing poly(A)-binding protein nuclear 1-mediated muscle wasting.
Fri Feb 22 00:00:00 EST 2019
Human-like NSG mouse glycoproteins sialylation pattern changes the phenotype of human lymphocytes and sensitivity to HIV-1 infection.
BMC immunology
Dagur RS,Branch-Woods A,Mathews S,Joshi PS,Quadros RM,Harms DW,Cheng Y,Miles SM,Pirruccello SJ,Gurumurthy CB,Gorantla S,Poluektova LY
MA5-15738 was used in Western Blotting to investigate multiple aspects of human immune system development.
Mon Jan 07 00:00:00 EST 2019
A genetically encoded single-wavelength sensor for imaging cytosolic and cell surface ATP.
Nature communications
Lobas MA,Tao R,Nagai J,Kronschläger MT,Borden PM,Marvin JS,Looger LL,Khakh BS
MA5-15738 was used in Western Blotting to show iATPSnFRs represent promising reagents for imaging ATP in the extracellular space and within cells during a variety of settings, and for further application-specific refinements.
Tue Feb 12 00:00:00 EST 2019
An ABCA4 loss-of-function mutation causes a canine form of Stargardt disease.
PLoS genetics
Mäkeläinen S,Gòdia M,Hellsand M,Viluma A,Hahn D,Makdoumi K,Zeiss CJ,Mellersh C,Ricketts SL,Narfström K,Hallböök F,Ekesten B,Andersson G,Bergström TF
MA5-15738 was used in Western Blotting to study a novel form of retinal degeneration in Labrador retriever dogs with clinical signs indicating cone and rod degeneration.
Fri Mar 01 00:00:00 EST 2019
SLMAP3 isoform modulates cardiac gene expression and function.
PloS one
Mlynarova J,Trentin-Sonoda M,Gaisler da Silva F,Major JL,Salih M,Carneiro-Ramos MS,Tuana BS
MA5-15738 was used in Western Blotting to study the role of three SLMAP isoforms in cardiac gene expression and function.
Mon Jan 13 00:00:00 EST 2020
Aspirin impairs acetyl-coenzyme A metabolism in redox-compromised yeast cells.
Scientific reports
Farrugia G,Azzopardi M,Saliba C,Grech G,Gross AS,Pistolic J,Benes V,Vassallo N,Borg J,Madeo F,Eisenberg T,Balzan R
MA5-15738 was used in Western Blotting to study aspirin's chemopreventive behaviour with respect to early stage cancer cells.
Tue Apr 16 00:00:00 EDT 2019
Role of Norepinephrine in IL-1β-Induced Chondrocyte Dedifferentiation under Physioxia.
International journal of molecular sciences
Speichert S,Molotkov N,El Bagdadi K,Meurer A,Zaucke F,Jenei-Lanzl Z
MA5-15738 was used in Western Blotting to analyse the contribution of norepinephrine to human articular osteoarthritis chondrocyte dedifferentiation in the absence or presence of interleukin-1Β.
Mon Mar 11 00:00:00 EDT 2019
A ribose-functionalized NAD+ with unexpected high activity and selectivity for protein poly-ADP-ribosylation.
Nature communications
Zhang XN,Cheng Q,Chen J,Lam AT,Lu Y,Dai Z,Pei H,Evdokimov NM,Louie SG,Zhang Y
MA5-15738 was used in Western Blotting to report the labeling of protein PARylation by 3'-azido NAD+ in the cellular context and facilitate direct visualization and labeling of mitochondrial protein PARylation.
Fri Sep 13 00:00:00 EDT 2019
Clinical candidate and genistein analogue AXP107-11 has chemoenhancing functions in pancreatic adenocarcinoma through G protein-coupled estrogen receptor signaling.
Cancer medicine
Mesmar F,Dai B,Ibrahim A,Hases L,Jafferali MH,Jose Augustine J,DiLorenzo S,Kang Y,Zhao Y,Wang J,Kim M,Lin CY,Berkenstam A,Fleming J,Williams C
MA5-15738 was used in Western Blotting to propose that activation of GPER1 may constitute a new avenue for pancreatic cancer therapeutics.
Sun Dec 01 00:00:00 EST 2019
N-Dihydrogalactochitosan Potentiates the Radiosensitivity of Liver Metastatic Tumor Cells Originated from Murine Breast Tumors.
International journal of molecular sciences
Wang CY,Chang CY,Wang CY,Liu K,Kang CY,Lee YJ,Chen WR
MA5-15738 was used in Western Blotting to suggest that the synergistic effects of GC and irradiation might be used to enhance the efficacy of radiotherapy in treating metastatic tumors.
Fri Nov 08 00:00:00 EST 2019
A Bacterial Effector Mimics a Host HSP90 Client to Undermine Immunity.
Cell
Lopez VA,Park BC,Nowak D,Sreelatha A,Zembek P,Fernandez J,Servage KA,Gradowski M,Hennig J,Tomchick DR,Pawłowski K,Krzymowska M,Tagliabracci VS
MA5-15738 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to demonstrate that phosphorylation of HSP90 prevents activation of immune receptors that trigger the hypersensitive response in plants.
Thu Sep 19 00:00:00 EDT 2019
Comparison of cofilin‑1 and Twist‑1 protein expression in human non‑small cell lung cancer tissues.
Oncology reports
Chang CY,Chang SL,Leu JD,Chang YC,Hsiao M,Lin LT,Lin HN,Lee YJ
MA5-15738 was used in Western Blotting to reveal that high expression levels of both cofilin‚1 (CFL1) and Twist‚1 (TWIST1) genes were associated with decreased survival of NSCLC patients, notably with regard to the adenocarcinoma subtype.
Thu Aug 01 00:00:00 EDT 2019
Altered NMDAR signaling underlies autistic-like features in mouse models of CDKL5 deficiency disorder.
Nature communications
Tang S,Terzic B,Wang IJ,Sarmiento N,Sizov K,Cui Y,Takano H,Marsh ED,Zhou Z,Coulter DA
MA5-15738 was used in Western Blotting to determine the pathogenic origin of the autistic features of CDKL5 deficiency disorder.
Fri Jun 14 00:00:00 EDT 2019
Development of Highly Sensitive Biosensors of RAF Dimerization in Cells.
Scientific reports
Miyamoto K,Sawa M
MA5-15738 was used in Western Blotting to develop highly sensitive biosensors of RAF dimerisation in cells utilising the split enhanced click beetle luciferase complementation technique.
Thu Jan 24 00:00:00 EST 2019
Targeted Delivery of Stk25 Antisense Oligonucleotides to Hepatocytes Protects Mice Against Nonalcoholic Fatty Liver Disease.
Cellular and molecular gastroenterology and hepatology
Cansby E,Nuñez-Durán E,Magnusson E,Amrutkar M,Booten SL,Kulkarni NM,Svensson LT,Borén J,Marschall HU,Aghajan M,Mahlapuu M
MA5-15738 was used in Western Blotting to provide in vivo nonclinical proof-of-principle for the metabolic benefit of liver-specific inhibition of STK25 in the context of obesity and warrants future investigations to address the therapeutic potential of GalNAc-Stk25 ASO in the prevention and treatment of NAFLD.
Tue Jun 04 00:00:00 EDT 2019
Disruption of mTOR and MAPK pathways correlates with severity in idiopathic autism.
Translational psychiatry
Rosina E,Battan B,Siracusano M,Di Criscio L,Hollis F,Pacini L,Curatolo P,Bagni C
MA5-15738 was used in Western Blotting to identify differential expression of mTOR and MAPK pathways in patients affected by mild and severe idiopathic autism.
Thu Jan 31 00:00:00 EST 2019
Restoration of primary cilia in obese adipose-derived mesenchymal stem cells by inhibiting Aurora A or extracellular signal-regulated kinase.
Stem cell research & therapy
Ritter A,Kreis NN,Roth S,Friemel A,Jennewein L,Eichbaum C,Solbach C,Louwen F,Yuan J
MA5-15738 was used in Western Blotting to describes a novel phenomenon whereby the primary cilium of obese ASCs is rescuable by the low-dose inhibition of Aurora A or Erk1/2, restoring functional ASCs with increased stemness.
Wed Aug 14 00:00:00 EDT 2019
Chk1 Inhibitor MK-8776 Restores the Sensitivity of Chemotherapeutics in P-glycoprotein Overexpressing Cancer Cells.
International journal of molecular sciences
Cui Q,Cai CY,Wang JQ,Zhang S,Gupta P,Ji N,Yang Y,Dong X,Yang DH,Chen ZS
MA5-15738 was used in Western Blotting to report that checkpoint kinase 1 inhibitor MK-8776 can enhance the sensitivity of chemotherapeutics that are substrates of P-glycoprotein in cancer cells.
Thu Aug 22 00:00:00 EDT 2019
Autophagy in Adipocyte Differentiation.
Methods in molecular biology (Clifton, N.J.)
Tao Z,Liu L,Zheng LD,Cheng Z
MA5-15738 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to describe the procedure of autophagy analysis during adipocyte differentiation.
Tue Jun 04 00:00:00 EDT 2019
The miRNA-449 family mediates doxorubicin resistance in triple-negative breast cancer by regulating cell cycle factors.
Scientific reports
Tormo E,Ballester S,Adam-Artigues A,Burgués O,Alonso E,Bermejo B,Menéndez S,Zazo S,Madoz-Gúrpide J,Rovira A,Albanell J,Rojo F,Lluch A,Eroles P
MA5-15738 was used in Western Blotting to analyse the involvement of the miRNA-449 family in the response to doxorubicin.
Fri Mar 29 00:00:00 EDT 2019
Sex differences in nicotine-enhanced Pavlovian conditioned approach in rats.
Biology of sex differences
Stringfield SJ,Madayag AC,Boettiger CA,Robinson DL
MA5-15738 was used in Western Blotting to investigate the role of sex on nicotine-induced changes to stimulus-response behavior and associated BDNF protein levels.
Wed Jul 17 00:00:00 EDT 2019
Norepinephrine Inhibits Synovial Adipose Stem Cell Chondrogenesis via α2a-Adrenoceptor-Mediated ERK1/2 Activation.
International journal of molecular sciences
El Bagdadi K,Zaucke F,Meurer A,Straub RH,Jenei-Lanzl Z
MA5-15738 was used in Western Blotting to confirm the important role of norepinephrine in synovial adipose tissue-derived stem cells chondrogenic function and provide new insight in osteoarthritis pathophysiology.
Wed Jun 26 00:00:00 EDT 2019
Mechano-signalling, induced by fullerene C60 nanofilms, arrests the cell cycle in the G2/M phase and decreases proliferation of liver cancer cells.
International journal of nanomedicine
Sosnowska M,Kutwin M,Jaworski S,Strojny B,Wierzbicki M,Szczepaniak J,Łojkowski M,Święszkowski W,Bałaban J,Chwalibog A,Sawosz E
MA5-15738 was used in Western Blotting to show that C60 nanofilms might be a suitable substitute component for the niche of cancer cells and may be an alternative treatment for hepatocellular carcinoma.
Fri Nov 08 00:00:00 EST 2019
Brain-specific Drp1 regulates postsynaptic endocytosis and dendrite formation independently of mitochondrial division.
eLife
Itoh K,Murata D,Kato T,Yamada T,Araki Y,Saito A,Adachi Y,Igarashi A,Li S,Pletnikov M,Huganir RL,Watanabe S,Kamiya A,Iijima M,Sesaki H
MA5-15738 was used in Western Blotting to study the function of Drp1ABCD in mouse neurons in both culture and animal systems using isoform-specific knockdown by shRNA and isoform-specific knockout by CRISPR/Cas9.
Fri Oct 11 00:00:00 EDT 2019
CCL2 mobilizes ALIX to facilitate Gag-p6 mediated HIV-1 virion release.
eLife
Ajasin DO,Rao VR,Wu X,Ramasamy S,Pujato M,Ruiz AP,Fiser A,Bresnick AR,Kalpana GV,Prasad VR
MA5-15738 was used in Western Blotting to show that CCL2-mediated increase in virus production requires Gag late motif LYPX present in HIV-1B, but absent in HIV-1C, and ALIX protein that recruits ESCRT III complex.
Fri Jun 07 00:00:00 EDT 2019
Acetyl-CoA carboxylase 1-dependent lipogenesis promotes autophagy downstream of AMPK.
The Journal of biological chemistry
Gross AS,Zimmermann A,Pendl T,Schroeder S,Schoenlechner H,Knittelfelder O,Lamplmayr L,Santiso A,Aufschnaiter A,Waltenstorfer D,Ortonobes Lara S,Stryeck S,Kast C,Ruckenstuhl C,Hofer SJ,Michelitsch B,Woelflingseder M,Müller R,Carmona-Gutierrez D,Madl T,Büttner S,Fröhlich KU,Shevchenko A,Eisenberg T
MA5-15738 was used in Western Blotting to show that in aging yeast autophagy levels highly depend on the activity of acetyl-coenzyme A carboxylase 1.
Fri Aug 09 00:00:00 EDT 2019
Effects of codon optimization on coagulation factor IX translation and structure: Implications for protein and gene therapies.
Scientific reports
Alexaki A,Hettiarachchi GK,Athey JC,Katneni UK,Simhadri V,Hamasaki-Katagiri N,Nanavaty P,Lin B,Takeda K,Freedberg D,Monroe D,McGill JR,Peters R,Kames JM,Holcomb DD,Hunt RC,Sauna ZE,Gelinas A,Janjic N,DiCuccio M,Bar H,Komar AA,Kimchi-Sarfaty C
MA5-15738 was used in SDS-PAGE to investigate the impact of synonymous codons usage on protein expression and function.
Tue Oct 29 00:00:00 EDT 2019
Quantitative Proteomics Links the Intermediate Filament Nestin to Resistance to Targeted BRAF Inhibition in Melanoma Cells.
Molecular & cellular proteomics : MCP
Schmitt M,Sinnberg T,Nalpas NC,Maass A,Schittek B,Macek B
MA5-15738 was used in Western Blotting to study the molecular processes that govern resistance to MAP kinase inhibitors in malignant melanoma.
Sat Jun 01 00:00:00 EDT 2019
Minor ginsenoside F1 improves memory in APP/PS1 mice.
Molecular brain
Han J,Oh JP,Yoo M,Cui CH,Jeon BM,Kim SC,Han JH
MA5-15738 was used in Western Blotting to suggest that minor ginsenoside F1 constitutes a promising target to develop therapeutic agents for AD.
Thu Sep 05 00:00:00 EDT 2019
Inward- and outward-facing X-ray crystal structures of homodimeric P-glycoprotein CmABCB1.
Nature communications
Kodan A,Yamaguchi T,Nakatsu T,Matsuoka K,Kimura Y,Ueda K,Kato H
MA5-15738 was used in Western Blotting to characterise a pair of structures of homodimeric P-glycoprotein: an outward-facing conformational state with bound nucleotide and an inward-facing apo state, at resolutions of 1.9 A and 3.0 A, respectively.
Tue Jan 08 00:00:00 EST 2019
Expression of mutant mRNA and protein in pancreatic cells derived from MODY3- iPS cells.
PloS one
Yabe SG,Nishida J,Fukuda S,Takeda F,Nasiro K,Yasuda K,Iwasaki N,Okochi H
MA5-15738 was used in Western Blotting to establish MODY3 patient-derived iPS cells using non-integrating Sendai virus vector and examined the mutant mRNA and protein of HNF1A after pancreatic lineage differentiation.
Wed Jan 29 00:00:00 EST 2020
Long noncoding RNA MALAT1 suppresses breast cancer metastasis.
Nature genetics
Kim J,Piao HL,Kim BJ,Yao F,Han Z,Wang Y,Xiao Z,Siverly AN,Lawhon SE,Ton BN,Lee H,Zhou Z,Gan B,Nakagawa S,Ellis MJ,Liang H,Hung MC,You MJ,Sun Y,Ma L
MA5-15738 was used in Western Blotting to study how the long noncoding RNA, MALAT1, suppresses breast cancer metastasis.
Sat Dec 01 00:00:00 EST 2018
A kindred with mutant IKAROS and autoimmunity.
The Journal of allergy and clinical immunology
Van Nieuwenhove E,Garcia-Perez JE,Helsen C,Rodriguez PD,van Schouwenburg PA,Dooley J,Schlenner S,van der Burg M,Verhoeyen E,Gijsbers R,Frietze S,Schjerven H,Meyts I,Claessens F,Humblet-Baron S,Wouters C,Liston A
MA5-15738 was used in Western Blotting to define the mechanism of action giving rise to autoimmunity in IKAROS deficiency.
Wed Aug 01 00:00:00 EDT 2018
Metformin Targets Mitochondrial Glycerophosphate Dehydrogenase to Control Rate of Oxidative Phosphorylation and Growth of Thyroid Cancer In Vitro and In Vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research
Thakur S,Daley B,Gaskins K,Vasko VV,Boufraqech M,Patel D,Sourbier C,Reece J,Cheng SY,Kebebew E,Agarwal S,Klubo-Gwiezdzinska J
MA5-15738 was used in Western Blotting to establish mitochondrial glycerophosphate dehydrogenase as a novel thyroid cancer growth regulator and metabolism that can be effectively targeted by metformin.
Wed Aug 15 00:00:00 EDT 2018
Regulation of BECN1-mediated autophagy by HSPB6: Insights from a human HSPB6S10F mutant.
Autophagy
Liu GS,Zhu H,Cai WF,Wang X,Jiang M,Essandoh K,Vafiadaki E,Haghighi K,Lam CK,Gardner G,Adly G,Nicolaou P,Sanoudou D,Liang Q,Rubinstein J,Fan GC,Kranias EG
MA5-15738 was used in Western Blotting to reveal a novel regulatory mechanism of heat shock protein family B [small] member 6 in cell survival through its interaction with BECN1.
Tue Feb 26 00:00:00 EST 2019
Delipidation of mammalian Atg8-family proteins by each of the four ATG4 proteases.
Autophagy
Kauffman KJ,Yu S,Jin J,Mugo B,Nguyen N,O'Brien A,Nag S,Lystad AH,Melia TJ
MA5-15738 was used in Western Blotting to suggest a model whereby ATG4B drives very fast priming of mammalian Atg8 proteins, whereas delipidation is inherently slow and regulated by all ATG4 homologs.
Wed Oct 02 00:00:00 EDT 2019
Identification of ANXA2 (annexin A2) as a specific bleomycin target to induce pulmonary fibrosis by impeding TFEB-mediated autophagic flux.
Autophagy
Wang K,Zhang T,Lei Y,Li X,Jiang J,Lan J,Liu Y,Chen H,Gao W,Xie N,Chen Q,Zhu X,Liu X,Xie K,Peng Y,Nice EC,Wu M,Huang C,Wei Y
MA5-15738 was used in Western Blotting to examine the mechanisms underlying bleomycin-induced pulmonary fibrosis.
Tue Feb 26 00:00:00 EST 2019
Fusogenic micropeptide Myomixer is essential for satellite cell fusion and muscle regeneration.
Proceedings of the National Academy of Sciences of the United States of America
Bi P,McAnally JR,Shelton JM,Sánchez-Ortiz E,Bassel-Duby R,Olson EN
MA5-15738 was used in Western Blotting to investigate the role of Myomixer in muscle regeneration.
Tue Apr 10 00:00:00 EDT 2018
Complement Component 3 Negatively Regulates Antibody Response by Modulation of Red Blood Cell Antigen.
Frontiers in immunology
Mener A,Arthur CM,Patel SR,Liu J,Hendrickson JE,Stowell SR
MA5-15738 was used in Western Blotting to study the ability of Complement Component 3 in suppressing antibody formation following blood transfusion.
Thu Jun 06 00:00:00 EDT 2019
Antibody-mediated immune suppression by antigen modulation is antigen-specific.
Blood advances
Maier CL,Mener A,Patel SR,Jajosky RP,Bennett AL,Arthur CM,Hendrickson JE,Stowell SR
MA5-15738 was used in Western Blotting to evaluate the specificity of antibody-mediated immune suppression.
Tue Nov 13 00:00:00 EST 2018
HEXIM1-Tat chimera inhibits HIV-1 replication.
PLoS pathogens
Leoz M,Kukanja P,Luo Z,Huang F,Cary DC,Peterlin BM,Fujinaga K
MA5-15738 was used in Western Blotting to design a chimeric inhibitor of HIV transcription by combining functional domains from HEXIM1 and Tat.
Thu Nov 01 00:00:00 EDT 2018
The Enzymatic Core of the Parkinson's Disease-Associated Protein LRRK2 Impairs Mitochondrial Biogenesis in Aging Yeast.
Frontiers in molecular neuroscience
Aufschnaiter A,Kohler V,Walter C,Tosal-Castano S,Habernig L,Wolinski H,Keller W,Vögtle FN,Büttner S
MA5-15738 was used in Western Blotting to study the effects of high levels of the enzymatic core of human leucine-rich repeat kinase 2 on mitochondrial biogenesis in ageing yeast.
Sat Jan 09 00:00:00 EST 2021
Modulation of Autophagy by a Small Molecule Inverse Agonist of ERRα Is Neuroprotective.
Frontiers in molecular neuroscience
Suresh SN,Chavalmane AK,Pillai M,Ammanathan V,Vidyadhara DJ,Yarreiphang H,Rai S,Paul A,Clement JP,Alladi PA,Manjithaya R
MA5-15738 was used in Western Blot to study the role of Oestrogen Related Receptor α in regulating autophagy flux.
Wed Aug 16 00:00:00 EDT 2023
miR-217-5p induces apoptosis by directly targeting PRKCI, BAG3, ITGAV and MAPK1 in colorectal cancer cells.
Journal of cell communication and signaling
Flum M,Kleemann M,Schneider H,Weis B,Fischer S,Handrick R,Otte K
MA5-15738 was used in Western Blotting to assess the pro-apoptotic potential of miR-217-5p in a variety of colorectal cancer cell lines.
Fri Jun 01 00:00:00 EDT 2018
Postnatal tendon growth and remodeling require platelet-derived growth factor receptor signaling.
American journal of physiology. Cell physiology
Sugg KB,Markworth JF,Disser NP,Rizzi AM,Talarek JR,Sarver DC,Brooks SV,Mendias CL
MA5-15738 was used in Western Blotting to study the role of platelet-derived growth factor receptor signalling during tendon growth and remodelling in adult animals.
Sun Apr 01 00:00:00 EDT 2018
Overexpression of hexokinase 2 reduces mitochondrial calcium overload in coronary endothelial cells of type 2 diabetic mice.
American journal of physiology. Cell physiology
Pan M,Han Y,Basu A,Dai A,Si R,Willson C,Balistrieri A,Scott BT,Makino A
MA5-15738 was used in Western Blotting to study the role of hexokinase 2 in coronary endothelial dysfunction in type 2 diabetes.
Fri Jun 01 00:00:00 EDT 2018
Phage-Antibiotic Synergy via Delayed Lysis.
Applied and environmental microbiology
Kim M,Jo Y,Hwang YJ,Hong HW,Hong SS,Park K,Myung H
MA5-15738 was used in Western Blotting to study phage antibiotic synergy in bacterium-phage pairs using different classes of antibiotics.
Thu Nov 15 00:00:00 EST 2018
Transforming growth factor β1 suppresses proinflammatory gene program independent of its regulation on vascular smooth muscle differentiation and autophagy.
Cellular signalling
Gao P,Wu W,Ye J,Lu YW,Adam AP,Singer HA,Long X
MA5-15738 was used in Western Blotting to demonstrate the role of TGFΒ signaling in blocking the STAT3 and NF-κB pathway, therefore providing novel insights into the mechanisms underlying the protective role of TGFΒ signaling in vascular diseases.
Mon Oct 01 00:00:00 EDT 2018
Melittin induces NSCLC apoptosis via inhibition of miR-183.
OncoTargets and therapy
Gao D,Zhang J,Bai L,Li F,Dong Y,Li Q
MA5-15738 was used in Western Blotting to evaluate the effect of melittin on non-small cell lung cancer.
Fri Mar 18 00:00:00 EDT 2022
Voluntary wheel running increases satellite cell abundance and improves recovery from disuse in gastrocnemius muscles from mice.
Journal of applied physiology (Bethesda, Md. : 1985)
Brooks MJ,Hajira A,Mohamed JS,Alway SE
MA5-15738 was used in Western Blotting to indicate that voluntary wheel running increased YAP signaling and satellite cell activity after HSU and this was associated with improved recovery.
Fri Jun 01 00:00:00 EDT 2018
ATM‑JAK‑PD‑L1 signaling pathway inhibition decreases EMT and metastasis of androgen‑independent prostate cancer.
Molecular medicine reports
Zhang L,Xu LJ,Zhu J,Li J,Xue BX,Gao J,Sun CY,Zang YC,Zhou YB,Yang DR,Shan YX
MA5-15738 was used in Western Blotting to suggest that ATM-JAK-PD-L1 signalling pathway inhibition can effectively suppress EMT, metastasis and progression of CRPC.
Tue May 01 00:00:00 EDT 2018
Effect and molecular mechanism of mTOR inhibitor rapamycin on temozolomide-induced autophagic death of U251 glioma cells.
Oncology letters
Li B,Zhou C,Yi L,Xu L,Xu M
MA5-15738 was used in Western Blotting to examine the effect of temozolomide (TMZ) combined with rapamycin on the TMZ-induced autophagic death of U251 glioma cells.
Thu Feb 01 00:00:00 EST 2018
miRNA-218 regulates the proliferation and apoptosis of cervical cancer cells via targeting Gli3.
Experimental and therapeutic medicine
Zhang J,Li S,Li Y,Liu H,Zhang Y,Zhang Q
MA5-15738 was used in Western Blotting to investigate the role of miR-218 in cervical cancer and to verify its underlying mechanism.
Sat Sep 01 00:00:00 EDT 2018
Core circadian clock gene expression in human dental pulp-derived cells in response to L-mimosine, hypoxia and echinomycin.
European journal of oral sciences
Janjić K,Kurzmann C,Moritz A,Agis H
MA5-15738 was used in Western Blotting to investigate if core clock genes are expressed in human dental pulp-derived cells (DPC) and if their expression is modulated by the hypoxia mimetic agent, L-mimosine (L-MIM), hypoxia or echinomycin.
Wed Aug 01 00:00:00 EDT 2018
MicroRNA-208a Correlates Apoptosis and Oxidative Stress Induced by H2O2 through Protein Tyrosine Kinase/Phosphatase Balance in Cardiomyocytes.
International heart journal
Liu A,Sun Y,Yu B
MA5-15738-1MG was used in Western Blotting to establish the role of miR-208a in myocardial I/R injury and the underlying cardio-protective mechanism.
Tue Jul 31 00:00:00 EDT 2018
Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein.
Nature communications
Ryan T,Bamm VV,Stykel MG,Coackley CL,Humphries KM,Jamieson-Williams R,Ambasudhan R,Mosser DD,Lipton SA,Harauz G,Ryan SD
MA5-15738 was used in Western Blotting to show that transmission of Parkinsons pathology is blocked using an anti-α-syn monoclonal antibody, consistent with cell-to-cell seeding of α-syn.
Mon Feb 26 00:00:00 EST 2018
VS-4718 Antagonizes Multidrug Resistance in ABCB1- and ABCG2-Overexpressing Cancer Cells by Inhibiting the Efflux Function of ABC Transporters.
Frontiers in pharmacology
Ji N,Yang Y,Cai CY,Lei ZN,Wang JQ,Gupta P,Teng QX,Chen ZS,Kong D,Yang DH
MA5-15738 was used in Western Blotting to investigate whether VS-4718 could reverse multi-drug resistance mediated by ATP-binding cassette transporters, including ABCB1, ABCG2, and ABCC1.
Wed Sep 30 00:00:00 EDT 2020
Local enrichment of HP1alpha at telomeres alters their structure and regulation of telomere protection.
Nature communications
Chow TT,Shi X,Wei JH,Guan J,Stadler G,Huang B,Blackburn EH
MA5-15738 was used in Western Blotting to develop a molecular tethering approach to experimentally enrich heterochromatin protein HP1α specifically at telomeres.
Tue Sep 04 00:00:00 EDT 2018
Herpes Simplex Virus Type 1 Enhances Expression of the Synaptic Protein Arc for Its Own Benefit.
Frontiers in cellular neuroscience
Acuña-Hinrichsen F,Muñoz M,Hott M,Martin C,Mancilla E,Salazar P,Leyton L,Zambrano A,Concha MI,Burgos PV,Otth C
MA5-15738 was used in Western Blotting to study the modulation of synaptic Arc expression by Herpes Simplex Virus Type 1 infection.
Thu Oct 01 00:00:00 EDT 2020
Altering lipid droplet homeostasis affects Coxiella burnetii intracellular growth.
PloS one
Mulye M,Zapata B,Gilk SD
MA5-15738 was used in Western Blotting to suggest that maintenance of lipid droplet homeostasis, possibly via the Coxiella burnetii Type 4B Secretion System, is critical for bacterial growth.
Wed Apr 18 00:00:00 EDT 2018
Do hypoxia and L-mimosine modulate sclerostin and dickkopf-1 production in human dental pulp-derived cells? Insights from monolayer, spheroid and tooth slice cultures.
BMC oral health
Janjić K,Cvikl B,Kurzmann C,Moritz A,Agis H
MA5-15738 was used in Western Blotting to reveal the effects of hypoxia and a hypoxia mimetic agent on the production of sclerostin and dickkopf-1 in human dental pulp-derived cells.
Fri Mar 09 00:00:00 EST 2018
EphB2 receptor tyrosine kinase promotes hepatic fibrogenesis in mice via activation of hepatic stellate cells.
Scientific reports
Mimche PN,Lee CM,Mimche SM,Thapa M,Grakoui A,Henkemeyer M,Lamb TJ
MA5-15738 was used in Western Blotting to identify that upregulation of EphB2 is a prominent feature of two mouse models of hepatic fibrosis and also observed in humans with liver cirrhosis.
Wed Feb 07 00:00:00 EST 2018
Postnatal Development and Distribution of Sympathetic Innervation in Mouse Skeletal Muscle.
International journal of molecular sciences
Straka T,Vita V,Prokshi K,Hörner SJ,Khan MM,Pirazzini M,Williams MPI,Hafner M,Zaglia T,Rudolf R
MA5-15738 was used in Western Blotting to examine the postnatal development and distribution of sympathetic innervation in different muscles.
Sun Jul 01 00:00:00 EDT 2018
PEGylated liposome-encapsulated rhenium-188 radiopharmaceutical inhibits proliferation and epithelial-mesenchymal transition of human head and neck cancer cells in vivo with repeated therapy.
Cell death discovery
Chang CY,Chen CC,Lin LT,Chang CH,Chen LC,Wang HE,Lee TW,Lee YJ
MA5-15738 was used in Western Blotting to investigate the biological and pharmaceutical responses of high rhenium-188-liposomal dosage in vivo.
Thu Oct 01 00:00:00 EDT 2020
A brain-enriched Drp1 isoform associates with lysosomes, late endosomes, and the plasma membrane.
The Journal of biological chemistry
Itoh K,Adachi Y,Yamada T,Suzuki TL,Otomo T,McBride HM,Yoshimori T,Iijima M,Sesaki H
MA5-15738 was used in Western Blotting to analyse Dynamin-related protein 1 (DRP1) transcripts in mouse tissues, to identify previously uncharacterised isoforms.
Fri Jul 27 00:00:00 EDT 2018
Inhibition of Bacterial Gene Transcription with an RpoN-Based Stapled Peptide.
Cell chemical biology
Payne SR,Pau DI,Whiting AL,Kim YJ,Pharoah BM,Moi C,Boddy CN,Bernal F
MA5-15738 was used in Functional Assay to employ the hydrocarbon stapled peptide methodology to design and synthesize stapled σ54 peptides capable of penetrating Gram-negative bacteria, binding the σ54 promoter, and blocking the interaction between endogenous σ54 and its target DNA sequence, thereby reducing transcription and activation of σ54 response genes.
Thu Sep 20 00:00:00 EDT 2018
Centella asiatica increases hippocampal synaptic density and improves memory and executive function in aged mice.
Brain and behavior
Gray NE,Zweig JA,Caruso M,Martin MD,Zhu JY,Quinn JF,Soumyanath A
MA5-15738 was used in Western Blotting to investigate the effects of Centella asiatica on a variety of cognitive tasks, synaptic density, and mitochondrial and antioxidant pathways.
Sun Jul 01 00:00:00 EDT 2018
Nuclear PTEN deficiency causes microcephaly with decreased neuronal soma size and increased seizure susceptibility.
The Journal of biological chemistry
Igarashi A,Itoh K,Yamada T,Adachi Y,Kato T,Murata D,Sesaki H,Iijima M
MA5-15738 was used in Western Blotting to advance the current understanding of the function of nuclear PTEN in vivo.
Fri Jun 15 00:00:00 EDT 2018
Cyclosporine A binding to COX-2 reveals a novel signaling pathway that activates the IRE1α unfolded protein response sensor.
Scientific reports
Groenendyk J,Paskevicius T,Urra H,Viricel C,Wang K,Barakat K,Hetz C,Kurgan L,Agellon LB,Michalak M
MA5-15738 was used in Western Blotting to identify a novel and unanticipated cyclosporine-dependent signalling pathway, with cyclosporine triggering direct activation of the unfolded protein response.
Mon Nov 12 00:00:00 EST 2018
Mutation in the intracellular chloride channel CLCC1 associated with autosomal recessive retinitis pigmentosa.
PLoS genetics
Li L,Jiao X,D'Atri I,Ono F,Nelson R,Chan CC,Nakaya N,Ma Z,Ma Y,Cai X,Zhang L,Lin S,Hameed A,Chioza BA,Hardy H,Arno G,Hull S,Khan MI,Fasham J,Harlalka GV,Michaelides M,Moore AT,Coban Akdemir ZH,Jhangiani S,Lupski JR,Cremers FPM,Qamar R,Salman A,Chilton J,Self J,Ayyagari R,Kabir F,Naeem MA,Ali M,Akram J,Sieving PA,Riazuddin S,Baple EL,Riazuddin SA,Crosby AH,Hejtmancik JF
MA5-15738 was used in Western Blotting to identify a mutation in the intracellular chloride channel, CLCC1, associated with autosomal recessive retinitis pigmentosa.
Wed Aug 01 00:00:00 EDT 2018
Small extracellular vesicles and their miRNA cargo are anti-apoptotic members of the senescence-associated secretory phenotype.
Aging
Terlecki-Zaniewicz L,Lämmermann I,Latreille J,Bobbili MR,Pils V,Schosserer M,Weinmüllner R,Dellago H,Skalicky S,Pum D,Almaraz JCH,Scheideler M,Morizot F,Hackl M,Gruber F,Grillari J
MA5-15738 was used in Western Blotting to study small extracellular vesicles and their microRNA cargo in the context of the senescence-associated secretory phenotype.
Sat May 19 00:00:00 EDT 2018
The Hsp70 co-chaperone Ydj1/HDJ2 regulates ribonucleotide reductase activity.
PLoS genetics
Sluder IT,Knighton LE,Truman AW
MA5-15738 was used in Western Blotting to identify the regulatory chaperons involved in ribonucleotide reductase activity.
Thu Nov 01 00:00:00 EDT 2018
AKT1 restricts the invasive capacity of head and neck carcinoma cells harboring a constitutively active PI3 kinase activity.
BMC cancer
Brolih S,Parks SK,Vial V,Durivault J,Mostosi L,Pouysségur J,Pagès G,Picco V
MA5-15738 was used in Western Blotting to suggest that the repressive action of PI3K/AKT1 on cellular invasive properties may be a mechanism common to several cancers.
Mon Mar 05 00:00:00 EST 2018
Bromodomain-containing protein 4-independent transcriptional activation by autoimmune regulator (AIRE) and NF-κB.
The Journal of biological chemistry
Huang F,Shao W,Fujinaga K,Peterlin BM
MA5-15738 was used in Western Blotting to conclude that direct interactions between AIRE, NF-κB, and P-TEFb result in efficient transcription of their target genes.
Fri Apr 06 00:00:00 EDT 2018
Genetic Reduction or Negative Modulation of mGlu7 Does Not Impact Anxiety and Fear Learning Phenotypes in a Mouse Model of MECP2 Duplication Syndrome.
ACS chemical neuroscience
Fisher NM,Gogliotti RG,Vermudez SAD,Stansley BJ,Conn PJ,Niswender CM
MA5-15738 was used in Western Blotting to study how mGlu7 expression and function is affected by changes in MeCP2 dosage as for Rett syndrome and MECP2 Duplication syndrome.
Wed Sep 19 00:00:00 EDT 2018
Overexpressed HDAC8 in cervical cancer cells shows functional redundancy of tubulin deacetylation with HDAC6.
Cell communication and signaling : CCS
Vanaja GR,Ramulu HG,Kalle AM
MA5-15738 was used in Western Blotting to study the precise subcellular location, function in normal cellular physiology, protein partners and substrates of histone deacetylase 8 in cervical cancer cells.
Wed May 02 00:00:00 EDT 2018
Apoptotic efficacy of multifaceted biosynthesized silver nanoparticles on human adenocarcinoma cells.
Scientific reports
Plackal Adimuriyil George B,Kumar N,Abrahamse H,Ray SS
MA5-15738 was used in Western Blotting to study the apoptotic efficacy of multifaceted biosynthesised silver nanoparticles on human adenocarcinoma cells.
Tue Sep 25 00:00:00 EDT 2018
Obesity-Activated Adipose-Derived Stromal Cells Promote Breast Cancer Growth and Invasion.
Neoplasia (New York, N.Y.)
Hillers LE,D'Amato JV,Chamberlin T,Paderta G,Arendt LM
MA5-15738 was used in Western Blotting to study the effects of obesity on adipose-derived stromal cells.
Thu Nov 01 00:00:00 EDT 2018
Cathepsin S Alters the Expression of Pro-Inflammatory Cytokines and MMP-9, Partially through Protease-Activated Receptor-2, in Human Corneal Epithelial Cells.
International journal of molecular sciences
Klinngam W,Fu R,Janga SR,Edman MC,Hamm-Alvarez SF
MA5-15738 was used in Western Blotting to investigate whether the increased pro-inflammatory cytokines and proteases are induced by cathepsin S activation of protease-activated receptor-2.
Fri Nov 09 00:00:00 EST 2018
Functional Assessment of Patient-Derived Retinal Pigment Epithelial Cells Edited by CRISPR/Cas9.
International journal of molecular sciences
Foltz LP,Howden SE,Thomson JA,Clegg DO
MA5-15738 was used in Western Blotting to perform a functional assessment of patient-derived retinal pigment epithelial cells edited by CRISPR/Cas9.
Wed Dec 19 00:00:00 EST 2018
Elevating expression of MeCP2 T158M rescues DNA binding and Rett syndrome-like phenotypes.
The Journal of clinical investigation
Lamonica JM,Kwon DY,Goffin D,Fenik P,Johnson BS,Cui Y,Guo H,Veasey S,Zhou Z
MA5-15738 was used in Western Blotting to demonstrate that increasing MeCP2 T158M protein expression is sufficient to mitigate Rett syndrome like phenotypes.
Mon May 01 00:00:00 EDT 2017
A novel autophagy modulator 6-Bio ameliorates SNCA/α-synuclein toxicity.
Autophagy
Suresh SN,Chavalmane AK,Dj V,Yarreiphang H,Rai S,Paul A,Clement JP,Alladi PA,Manjithaya R
MA515738 was used in western blot to describe the effects of 6-Bio using a preclinical model of Parkinson disease
Mon Jul 03 00:00:00 EDT 2017
Frequent mild head injury promotes trigeminal sensitivity concomitant with microglial proliferation, astrocytosis, and increased neuropeptide levels in the trigeminal pain system.
The journal of headache and pain
Tyburski AL,Cheng L,Assari S,Darvish K,Elliott MB
MA5-15738 was used in Western Blotting to show that an increased frequency and a reduced time interval between injuries worsen headache behavior after mild closed head injury in rats.
Fri Dec 01 00:00:00 EST 2017
RECQ-like helicases Sgs1 and BLM regulate R-loop-associated genome instability.
The Journal of cell biology
Chang EY,Novoa CA,Aristizabal MJ,Coulombe Y,Segovia R,Chaturvedi R,Shen Y,Keong C,Tam AS,Jones SJM,Masson JY,Kobor MS,Stirling PC
MA5-15738 was used in Western Blotting to show that SGS1 loss increases R-loop accumulation and sensitises cells to transcription-replication collisions.
Mon Dec 04 00:00:00 EST 2017
A module for Rac temporal signal integration revealed with optogenetics.
The Journal of cell biology
Graziano BR,Gong D,Anderson KE,Pipathsouk A,Goldberg AR,Weiner OD
MA5-15738 was used in Western Blotting to probe the basis of neutrophil adaptation.
Mon Aug 07 00:00:00 EDT 2017
RASSF4 controls SOCE and ER-PM junctions through regulation of PI(4,5)P2.
The Journal of cell biology
Chen YJ,Chang CL,Lee WR,Liou J
MA5-15738 was used in Western Blotting to identify new functional roles of RAS association domain family 4.
Mon Jul 03 00:00:00 EDT 2017
Conditioned medium from LS 174T goblet cells treated with oxyresveratrol strengthens tight junctions in Caco-2 cells.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Hwang D,Jo H,Hwang S,Kim JK,Kim IH,Lim YH
MA515738 was used in western blot to determine effect of oxyresveratrol on intestinal tight junctions through stimulation of trefoil factor 3 production in goblet cells
Sun Jan 01 00:00:00 EST 2017
The Use of Platelet-Rich and Platelet-Poor Plasma to Enhance Differentiation of Skeletal Myoblasts: Implications for the Use of Autologous Blood Products for Muscle Regeneration.
The American journal of sports medicine
Miroshnychenko O,Chang WT,Dragoo JL
MA515738 was used in western blot to distinguish the effects of the non-neutrophil-containing plasma fractions on human skeletal muscle myoblast differentiation
Wed Mar 01 00:00:00 EST 2017
Loss of CDKL5 in Glutamatergic Neurons Disrupts Hippocampal Microcircuitry and Leads to Memory Impairment in Mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Tang S,Wang IJ,Yue C,Takano H,Terzic B,Pance K,Lee JY,Cui Y,Coulter DA,Zhou Z
MA5-15738 was used in Western Blotting to examine the effects of specifically ablating cyclin-dependent kinase-like 5 expression from forebrain glutamatergic neurons in mice.
Wed Aug 02 00:00:00 EDT 2017
Expression and Subcellular Localization of the Kaposi's Sarcoma-Associated Herpesvirus K15P Protein during Latency and Lytic Reactivation in Primary Effusion Lymphoma Cells.
Journal of virology
Smith CG,Kharkwal H,Wilson DW
MA5-15738 was used in Western Blotting to examine the relationships between the various molecular weight forms of K15P, their subcellular distribution, and how these may differ in latent and lytic Kaposi's sarcoma-associated herpesvirus infections.
Wed Nov 01 00:00:00 EDT 2017
Progerin sequestration of PCNA promotes replication fork collapse and mislocalization of XPA in laminopathy-related progeroid syndromes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Hilton BA,Liu J,Cartwright BM,Liu Y,Breitman M,Wang Y,Jones R,Tang H,Rusinol A,Musich PR,Zou Y
MA5-15738 was used in Western Blotting to propose a mechanism for progerin-induced genome instability and accelerated replicative senescence in HGPS.
Fri Sep 01 00:00:00 EDT 2017
Mitochondrial connexin40 regulates mitochondrial calcium uptake in coronary endothelial cells.
American journal of physiology. Cell physiology
Guo R,Si R,Scott BT,Makino A
MA515738 was used in western blot to determine the role of mitochondrial Cx40 in endothelial cells
Sat Apr 01 00:00:00 EDT 2017
Fragile X related protein 1 (FXR1P) regulates proliferation of adult neural stem cells.
Human molecular genetics
Patzlaff NE,Nemec KM,Malone SG,Li Y,Zhao X
MA5-15738 was used in Western Blotting to indicate that Fragile X related protein 1 plays an important role in regulating adult neural stem cell self-renewal and maintenance in the adult brain.
Sat Apr 01 00:00:00 EDT 2017
Protective Effect of Met12, a Small Peptide Inhibitor of Fas, on the Retinal Pigment Epithelium and Photoreceptor After Sodium Iodate Injury.
Investigative ophthalmology & visual science
Xiao J,Yao J,Jia L,Lin C,Zacks DN
MA5-15738 was used in Western Blotting to test the hypothesis that activation of the fas receptor contributes to the death of the rpe and photoreceptors.
Wed Mar 01 00:00:00 EST 2017
Expression of Cav1.3 calcium channel in the human and mouse colon: posttranscriptional inhibition by IFNγ.
American journal of physiology. Gastrointestinal and liver physiology
Radhakrishnan VM,Gilpatrick MM,Parsa NA,Kiela PR,Ghishan FK
MA515738 was used in western blot to elucidate how calcium-dependent signaling contributes to colitis
Sun Jan 01 00:00:00 EST 2017
Rafoxanide and Closantel Inhibit SPAK and OSR1 Kinases by Binding to a Highly Conserved Allosteric Site on Their C-terminal Domains.
ChemMedChem
AlAmri MA,Kadri H,Alderwick LJ,Simpkins NS,Mehellou Y
MA515738 was used in western blot to identify and study the allosteric pockets of SPAK and OSR1
Tue May 09 00:00:00 EDT 2017
Annexin A6 controls neuronal membrane dynamics throughout chick cranial sensory gangliogenesis.
Developmental biology
Shah A,Schiffmacher AT,Taneyhill LA
MA5-15738 was used in Western Blotting to provide novel insight into mechanisms underscoring morphological changes within placode cell-derived neurons that are essential for cranial gangliogenesis.
Mon May 01 00:00:00 EDT 2017
TUBB4A mutations result in specific neuronal and oligodendrocytic defects that closely match clinically distinct phenotypes.
Human molecular genetics
Curiel J,Rodríguez Bey G,Takanohashi A,Bugiani M,Fu X,Wolf NI,Nmezi B,Schiffmann R,Bugaighis M,Pierson T,Helman G,Simons C,van der Knaap MS,Liu J,Padiath Q,Vanderver A
MA5-15738 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to conclude that the different clinical phenotypes associated with TUBB4A reflect the selective and specific cellular effects of the causative mutations.
Wed Nov 15 00:00:00 EST 2017
Survivin, a key player in cancer progression, increases in obesity and protects adipose tissue stem cells from apoptosis.
Cell death & disease
Ejarque M,Ceperuelo-Mallafré V,Serena C,Pachón G,Núñez-Álvarez Y,Terrón-Puig M,Calvo E,Núñez-Roa C,Oliva-Olivera W,Tinahones FJ,Peinado MA,Vendrell J,Fernández-Veledo S
MA5-15738 was used in Western Blotting to investigate the impact of obesity on the expression of survivin, an anti-apoptotic protein upregulated by adipokines and a diagnostic biomarker of tumour onset and recurrence.
Thu May 18 00:00:00 EDT 2017
Plasmodium parasite as an effective hepatocellular carcinoma antigen glypican-3 delivery vector.
Oncotarget
Liu Q,Yang Y,Tan X,Tao Z,Adah D,Yu S,Lu J,Zhao S,Qin L,Qin L,Chen X
MA5-15738 was used in Western Blotting to show that a Plasmodium-based vector is highly efficient in inducing tumour antigen-specific T cell-mediated immunity and protection against tumour cells.
Tue Apr 11 00:00:00 EDT 2017
Influenza virus genome reaches the plasma membrane via a modified endoplasmic reticulum and Rab11-dependent vesicles.
Nature communications
de Castro Martin IF,Fournier G,Sachse M,Pizarro-Cerda J,Risco C,Naffakh N
MA5-15738 was used in Western Blotting to reveal that the endomembrane organelle that is primarily involved in the transport of vRNPs is the ER.
Thu Nov 09 00:00:00 EST 2017
Neuroprotective effect of Ruminococcus albus on oxidatively stressed SH-SY5Y cells and animals.
Scientific reports
Park J,Lee J,Yeom Z,Heo D,Lim YH
MA5-15738 was used in Western Blotting to investigate the effects of intestinal Ruminococcus albus with probiotic potential on neuroprotection in oxidatively stressed SH-SY5Y neuroblastoma cells and animals.
Mon Nov 06 00:00:00 EST 2017
Small-size recombinant adenoviral hexon protein fragments for the production of virus-type specific antibodies.
Virology journal
Pacesa M,Hendrickx R,Bieri M,Flatt JW,Greber UF,Hemmi S
MA5-15738 was used in Western Blotting to develop a novel method for the production of hyper-variable regions 1-6 of the adenoviral hexon protein and specific antibody generation.
Fri Aug 18 00:00:00 EDT 2017
GDF15 deficiency exacerbates chronic alcohol- and carbon tetrachloride-induced liver injury.
Scientific reports
Chung HK,Kim JT,Kim HW,Kwon M,Kim SY,Shong M,Kim KS,Yi HS
MA5-15738 was used in Western Blotting to determine the role played by Growth differentiation factor 15, in response to alcohol or carbon tetrachloride, in ameliorating liver inflammation and fibrosis.
Fri Dec 08 00:00:00 EST 2017
REST regulates the cell cycle for cardiac development and regeneration.
Nature communications
Zhang D,Wang Y,Lu P,Wang P,Yuan X,Yan J,Cai C,Chang CP,Zheng D,Wu B,Zhou B
MA5-15738 was used in Western Blotting to demonstrate the regulatory role of the RE1 silencing transcription factor (REST) and p21 during the cardiomyocyte cell cycle.
Thu Dec 07 00:00:00 EST 2017
The c-Jun N-terminal kinase prevents oxidative stress induced by UV and thermal stresses in corals and human cells.
Scientific reports
Courtial L,Picco V,Grover R,Cormerais Y,Rottier C,Labbe A,Pagès G,Ferrier-Pagès C
MA5-15738 was used in Western Blotting to suggest that an ancestral response, involving the JNK pathway, is remarkably conserved from corals to human, protecting cells from the adverse environmental effects.
Tue Apr 04 00:00:00 EDT 2017
Heat-shock protein 90 (Hsp90) promotes opioid-induced anti-nociception by an ERK mitogen-activated protein kinase (MAPK) mechanism in mouse brain.
The Journal of biological chemistry
Lei W,Mullen N,McCarthy S,Brann C,Richard P,Cormier J,Edwards K,Bilsky EJ,Streicher JM
MA5-15738 was used in Western Blotting to study the role of heat-shock protein 90 in opioid-induced μ-opioid receptor signalling and pain.
Fri Jun 23 00:00:00 EDT 2017
SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development.
The EMBO journal
Raducu M,Fung E,Serres S,Infante P,Barberis A,Fischer R,Bristow C,Thézénas ML,Finta C,Christianson JC,Buffa FM,Kessler BM,Sibson NR,Di Marcotullio L,Toftgård R,D'Angiolella V
MA5-15738 was used in Western blotting following immunoprecipitation to demonstrate FbXenopus laevis17-SCF functional complex formation, and targeting of the tumor suppressor Sufu for proteolysis in the nuclear compartment upon hedgehog pathway activation.
Fri Jul 01 00:00:00 EDT 2016
Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses.
Proceedings of the National Academy of Sciences of the United States of America
Li Y,Banerjee S,Wang Y,Goldstein SA,Dong B,Gaughan C,Silverman RH,Weiss SR
MA5-15738 was used in western blot determine which 2',5'-oligoadenylate synthetase regulates RNase L activation during viral infection
Tue Feb 23 00:00:00 EST 2016
Coordinated Upregulation of Mitochondrial Biogenesis and Autophagy in Breast Cancer Cells: The Role of Dynamin Related Protein-1 and Implication for Breast Cancer Treatment.
Oxidative medicine and cellular longevity
Zou P,Liu L,Zheng LD,Payne KK,Manjili MH,Idowu MO,Zhang J,Schmelz EM,Cheng Z
MA5-15738 was used in Western Blotting to study the regulation of mitochondrial quality through biogenesis and mitophagy and the relationship to tumour growth in breast cancer cells.
Mon Mar 13 00:00:00 EDT 2017
Zinc finger protein 407 overexpression upregulates PPAR target gene expression and improves glucose homeostasis in mice.
American journal of physiology. Endocrinology and metabolism
Charrier A,Wang L,Stephenson EJ,Ghanta SV,Ko CW,Croniger CM,Bridges D,Buchner DA
MA515738 was used in western blot to report that Zfp407 overexpression improved glucose homeostasis
Tue Nov 01 00:00:00 EDT 2016
Cancer cells become less deformable and more invasive with activation of β-adrenergic signaling.
Journal of cell science
Kim TH,Gill NK,Nyberg KD,Nguyen AV,Hohlbauch SV,Geisse NA,Nowell CJ,Sloan EK,Rowat AC
MA5-15738 was used in Western Blotting to show how activation of Β-adrenergic signalling causes cancer cells to become less deformable and more invasive.
Thu Dec 15 00:00:00 EST 2016
Brief Communication: SIR-2.1-dependent lifespan extension of Caenorhabditis elegans by oxyresveratrol and resveratrol.
Experimental biology and medicine (Maywood, N.J.)
Lee J,Kwon G,Park J,Kim JK,Lim YH
MA5-15738 was used in western blot to study the lifespan extension of Caenorhabditis elegans by resveratrol and oxyresveratrol by SIR-2.1-dependence
Sat Oct 01 00:00:00 EDT 2016
Exercise training reverses myocardial dysfunction induced by CaMKIIδC overexpression by restoring Ca2+ homeostasis.
Journal of applied physiology (Bethesda, Md. : 1985)
Høydal MA,Stølen TO,Kettlewell S,Maier LS,Brown JH,Sowa T,Catalucci D,Condorelli G,Kemi OJ,Smith GL,Wisløff U
MA515738 was used in western blot to study the role of cytosolic Ca(2+)/calmodulin-dependent protein kinase II in the high-intensity endurance training that reduces cardiac dysfunction
Fri Jul 01 00:00:00 EDT 2016
Concomitant beige adipocyte differentiation upon induction of mesenchymal stem cells into brown adipocytes.
Biochemical and biophysical research communications
Wang YL,Lin SP,Hsieh PC,Hung SC
MA515738 was used in western blot to investigate the differentiation of mesenchymal stem cells into beige/brown adipocytes
Fri Sep 16 00:00:00 EDT 2016
Gamma-interferon-inducible lysosomal thiol reductase is upregulated in human melanoma.
Melanoma research
Nguyen J,Bernert R,In K,Kang P,Sebastiao N,Hu C,Hastings KT
MA5-15738 was used in western blot to investigate gamma-interferon-inducible lysosomal thiol reductase expression in melanoma
Fri Apr 01 00:00:00 EDT 2016
Stiffness of pancreatic cancer cells is associated with increased invasive potential.
Integrative biology : quantitative biosciences from nano to macro
Nguyen AV,Nyberg KD,Scott MB,Welsh AM,Nguyen AH,Wu N,Hohlbauch SV,Geisse NA,Gibb EA,Robertson AG,Donahue TR,Rowat AC
MA5-15738 was used in western blot to report that stiffer pancreatic ductal adenocarcinoma cells are more invasive than more compliant cells
Mon Dec 05 00:00:00 EST 2016
Influence of Matrices on 3D-Cultured Prostate Cancer Cells' Drug Response and Expression of Drug-Action Associated Proteins.
PloS one
Edmondson R,Adcock AF,Yang L
MA5-15738 was used in western blot to characterize 3D-cultured prostate cancer cells' drug response and expression of drug-action associated proteins and the influence of matrices
Mon Jul 24 00:00:00 EDT 2017
Registered report: A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations.
eLife
Haven B,Heilig E,Donham C,Settles M,Vasilevsky N,Owen K
MA5-15738 was used in western blot to discuss the findings of The Reproducibility Project: Cancer Biology
Tue Feb 23 00:00:00 EST 2016
Biocontainment of genetically modified organisms by synthetic protein design.
Nature
Mandell DJ,Lajoie MJ,Mee MT,Takeuchi R,Kuznetsov G,Norville JE,Gregg CJ,Stoddard BL,Church GM
MA5-15738 was used in western blot to generate safer genetically modified organisms that are dependent on synthetic metabolites.
Thu Feb 05 00:00:00 EST 2015
Inhibition of notch signalling ameliorates experimental inflammatory arthritis.
Annals of the rheumatic diseases
Park JS,Kim SH,Kim K,Jin CH,Choi KY,Jang J,Choi Y,Gwon AR,Baik SH,Yun UJ,Chae SY,Lee S,Kang YM,Lee KC,Arumugam TV,Mattson MP,Park JH,Jo DG
MA5-15738 was used in western blot to test whether Notch signaling plays a role in rheumatoid arthritis
Thu Jan 01 00:00:00 EST 2015
Defects of Lipid Synthesis Are Linked to the Age-Dependent Demyelination Caused by Lamin B1 Overexpression.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Rolyan H,Tyurina YY,Hernandez M,Amoscato AA,Sparvero LJ,Nmezi BC,Lu Y,Estécio MR,Lin K,Chen J,He RR,Gong P,Rigatti LH,Dupree J,Bayır H,Kagan VE,Casaccia P,Padiath QS
MA5-15738 was used in western blot to elucidate the mechanisms by which increased LMNB1 levels cause autosomal dominant leukodystrophy
Wed Aug 26 00:00:00 EDT 2015
Quantitative Proteomic Verification of Membrane Proteins as Potential Therapeutic Targets Located in the 11q13 Amplicon in Cancers.
Journal of proteome research
Hoover H,Li J,Marchese J,Rothwell C,Borawoski J,Jeffery DA,Gaither LA,Finkel N
MA5-15738 was used in western blot to investigate alterations in surface protein expression associated with the 11q13 amplicon
Fri Sep 04 00:00:00 EDT 2015
The novel function of JADE1S in cytokinesis of epithelial cells.
Cell cycle (Georgetown, Tex.)
Siriwardana NS,Meyer RD,Panchenko MV
MA5-15738 was used in western blot to investigate the mechanisms of cell cycle regulation by the small isoform of JADE1.
Wed Jun 22 00:00:00 EDT 2016
Nebulin deficiency in adult muscle causes sarcomere defects and muscle-type-dependent changes in trophicity: novel insights in nemaline myopathy.
Human molecular genetics
Li F,Buck D,De Winter J,Kolb J,Meng H,Birch C,Slater R,Escobar YN,Smith JE,Yang L,Konhilas J,Lawlor MW,Ottenheijm C,Granzier HL
MA5-15738 was used in western blot investigate the role of nebulin in muscle cells using transgenic mice
Tue Sep 15 00:00:00 EDT 2015
Histone Sprocket Arginine Residues Are Important for Gene Expression, DNA Repair, and Cell Viability in Saccharomyces cerevisiae.
Genetics
Hodges AJ,Gallegos IJ,Laughery MF,Meas R,Tran L,Wyrick JJ
MA5-15738 was used in western blot to characterize histone sprocket arginine residue mutants in yeast
Wed Jul 01 00:00:00 EDT 2015
Chronic and acute LRRK2 silencing has no long-term behavioral effects, whereas wild-type and mutant LRRK2 overexpression induce motor and cognitive deficits and altered regulation of dopamine release.
Parkinsonism & related disorders
Volta M,Cataldi S,Beccano-Kelly D,Munsie L,Tatarnikov I,Chou P,Bergeron S,Mitchell E,Lim R,Khinda J,Lloret A,Bennett CF,Paradiso C,Morari M,Farrer MJ,Milnerwood AJ
MA5-15738 was used in western blot to compare cognitive and motor behaviors in various LRRK2 transgenic mice
Thu Oct 01 00:00:00 EDT 2015
Pseudouridine in mRNA: Incorporation, Detection, and Recoding.
Methods in enzymology
Wu G,Huang C,Yu YT
MA5-15738 was used in western blot to develop methods to study pseudouridylation of mRNA
Mon May 09 00:00:00 EDT 2016
Legionella suppresses the host unfolded protein response via multiple mechanisms.
Nature communications
Treacy-Abarca S,Mukherjee S
MA5-15738 was used in western blot to examine the role of the host unfolded protein response during L. pneumophila infection
Wed Jul 29 00:00:00 EDT 2015
Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing.
eLife
Zhang L,Tran NT,Su H,Wang R,Lu Y,Tang H,Aoyagi S,Guo A,Khodadadi-Jamayran A,Zhou D,Qian K,Hricik T,Côté J,Han X,Zhou W,Laha S,Abdel-Wahab O,Levine RL,Raffel G,Liu Y,Chen D,Li H,Townes T,Wang H,Deng H,Zheng YG,Leslie C,Luo M,Zhao X
MA5-15738 was used in western blot to report that PRMT1 regulates alternative RNA splicing by reducing RBM15
Tue Nov 17 00:00:00 EST 2015
Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1.
Cell
Freund A,Zhong FL,Venteicher AS,Meng Z,Veenstra TD,Frydman J,Artandi SE
MA5-15738 was used in western blot to investigate TRiC-mediated protein folding in the telomerase pathway.
Thu Dec 04 00:00:00 EST 2014
Expression of matriptase correlates with tumour progression and clinical prognosis in oral squamous cell carcinoma.
Histopathology
Cheng MF,Huang MS,Lin CS,Lin LH,Lee HS,Jiang JC,Hsia KT
MA5-15738 was used in western blot to study the prognostic value of the immunohistochemical expression of matriptase in patients with oral squamous cell carcinoma
Tue Jul 01 00:00:00 EDT 2014
Identification of human cytomegalovirus genes important for biogenesis of the cytoplasmic virion assembly complex.
Journal of virology
Das S,Ortiz DA,Gurczynski SJ,Khan F,Pellett PE
MA5-15738 was used in Western Blotting to identify human cytomegalovirus proteins that regulate cytoplasmic virion assembly complex biogenesis.
Fri Aug 01 00:00:00 EDT 2014
Behavioral deficits and striatal DA signaling in LRRK2 p.G2019S transgenic rats: a multimodal investigation including PET neuroimaging.
Journal of Parkinson's disease
Walker MD,Volta M,Cataldi S,Dinelle K,Beccano-Kelly D,Munsie L,Kornelsen R,Mah C,Chou P,Co K,Khinda J,Mroczek M,Bergeron S,Yu K,Cao LP,Funk N,Ott T,Galter D,Riess O,Biskup S,Milnerwood AJ,Stoessl AJ,Farrer MJ,Sossi V
MA5-15738 was used in western blot to examine the p.G2019S mutation in the leucine-rich repeat kinase 2 (LRRK2) and it's role in Parkinson's disease
Mon Jul 27 00:00:00 EDT 2015
Sensitization of mesothelioma cells to platinum-based chemotherapy by GSTπ knockdown.
Biochemical and biophysical research communications
Chen J,Solomides C,Simpkins H
MA5-15738 was used in western blot to study the ability of siRNA-mediated knockdown of GST-pi to increase the sensitivity of mesothelioma cells to platinum-based chemotherapy
Fri Apr 25 00:00:00 EDT 2014
Genome-wide screening identified that miR-134 acts as a metastasis suppressor by targeting integrin β1 in hepatocellular carcinoma.
PloS one
Zha R,Guo W,Zhang Z,Qiu Z,Wang Q,Ding J,Huang S,Chen T,Gu J,Yao M,He X
MA5-15738 was used in western blot to study the role of integrin beta1 in the metastasis suppressor activity of miRNA-134 in hepatocellular carcinoma
Wed Dec 03 00:00:00 EST 2014
The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes.
Nature communications
Huether R,Dong L,Chen X,Wu G,Parker M,Wei L,Ma J,Edmonson MN,Hedlund EK,Rusch MC,Shurtleff SA,Mulder HL,Boggs K,Vadordaria B,Cheng J,Yergeau D,Song G,Becksfort J,Lemmon G,Weber C,Cai Z,Dang J,Walsh M,Gedman AL,Faber Z,Easton J,Gruber T,Kriwacki RW,Partridge JF,Ding L,Wilson RK,Mardis ER,Mullighan CG,Gilbertson RJ,Baker SJ,Zambetti G,Ellison DW,Zhang J,Downing JR
MA5-15738 was used in western blot to sequence 633 genes encoding epigenetic regulatory proteins across 1000 pediatric cancer genomes
Tue Apr 08 00:00:00 EDT 2014
Deubiquitylation and stabilization of PTEN by USP13.
Nature cell biology
Zhang J,Zhang P,Wei Y,Piao HL,Wang W,Maddika S,Wang M,Chen D,Sun Y,Hung MC,Chen J,Ma L
MA5-15738 was used in western blot to identify the deubiquitinylating enzyme that stablilizes PTEN
Sun Dec 01 00:00:00 EST 2013
Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts.
The Journal of clinical investigation
Shim JH,Greenblatt MB,Zou W,Huang Z,Wein MN,Brady N,Hu D,Charron J,Brodkin HR,Petsko GA,Zaller D,Zhai B,Gygi S,Glimcher LH,Jones DC
MA5-15738 was used in western blot to determine how Schnurri-3 functions in osteoblasts
Sun Sep 01 00:00:00 EDT 2013
A transient α-helical molecular recognition element in the disordered N-terminus of the Sgs1 helicase is critical for chromosome stability and binding of Top3/Rmi1.
Nucleic acids research
Kennedy JA,Daughdrill GW,Schmidt KH
MA5-15738 was used in western blot to study the N terminus of Sgs1 helicase
Sun Dec 01 00:00:00 EST 2013
The promotion of functional recovery and nerve regeneration after spinal cord injury by lentiviral vectors encoding Lingo-1 shRNA delivered by Pluronic F-127.
Biomaterials
Wu HF,Cen JS,Zhong Q,Chen L,Wang J,Deng DY,Wan Y
MA5-15738 was used in western blot to examine the effects of Lingo-1 knockdown on recovery after spinal cord injury
Fri Feb 01 00:00:00 EST 2013
Epithelial-mesenchymal transition and tumor suppression are controlled by a reciprocal feedback loop between ZEB1 and Grainyhead-like-2.
Cancer research
Cieply B,Farris J,Denvir J,Ford HL,Frisch SM
MA5-15738 was used in western blot to study how epithelial-mesenchymal transition is controlled
Tue Oct 15 00:00:00 EDT 2013
Endothelial glucocorticoid receptor is required for protection against sepsis.
Proceedings of the National Academy of Sciences of the United States of America
Goodwin JE,Feng Y,Velazquez H,Sessa WC
MA5-15738 was used in western blot to investigate the role of endothelial glucocorticoid receptor in sepsis
Wed Jan 02 00:00:00 EST 2013
Oleanolic acid and ursolic acid: novel hepatitis C virus antivirals that inhibit NS5B activity.
Antiviral research
Kong L,Li S,Liao Q,Zhang Y,Sun R,Zhu X,Zhang Q,Wang J,Wu X,Fang X,Zhu Y
MA5-15738 was used in western blot to investigate novel hepatitis C antivirals
Mon Apr 01 00:00:00 EDT 2013
A small molecule multi-kinase inhibitor reduces influenza A virus replication by restricting viral RNA synthesis.
Antiviral research
Martinez-Gil L,Alamares-Sapuay JG,Ramana Reddy MV,Goff PH,Premkumar Reddy E,Palese P
MA5-15738 was used in western blot to test whether kinase inhibitors can inhibit influenza virus replication
Tue Oct 01 00:00:00 EDT 2013
Glucocorticoid receptor-beta up-regulation and steroid resistance induction by IL-17 and IL-23 cytokine stimulation in peripheral mononuclear cells.
Journal of clinical immunology
Vazquez-Tello A,Halwani R,Hamid Q,Al-Muhsen S
MA5-15738 was used in western blot to investigate whether Th-17 associated cytokines induce steroid insensitivity
Fri Feb 01 00:00:00 EST 2013
Novel oleanolic vinyl boronates: synthesis and antitumor activity.
European journal of medicinal chemistry
Moreira VM,Salvador JA,Simões S,Destro F,Gavioli R
MA5-15738 was used in western blot to investigate the antitumor activity of novel oleanolic vinyl boronates
Wed May 01 00:00:00 EDT 2013
Redox modification of ryanodine receptors by mitochondria-derived reactive oxygen species contributes to aberrant Ca2+ handling in ageing rabbit hearts.
The Journal of physiology
Cooper LL,Li W,Lu Y,Centracchio J,Terentyeva R,Koren G,Terentyev D
MA5-15738 was used in western blot to study the modification of ryanodine receptors by mitochondrially active ROS as a mechanism leading to abnormal Ca(2+) metabolism in the aging heart
Sun Dec 01 00:00:00 EST 2013
Follicle-stimulating hormone inhibits apoptosis in ovarian cancer cells by regulating the OCT4 stem cell signaling pathway.
International journal of oncology
Zhang Z,Zhu Y,Lai Y,Wu X,Feng Z,Yu Y,Bast RC,Wan X,Xi X,Feng Y
MA5-15738 was used in western blot to study the role of the OCT4 stem cell pathway in the mechanism by which FSH inhibits ovarian cancer cell apoptosis and the therapeutic implications
Tue Oct 01 00:00:00 EDT 2013
Involvement of endoplasmic reticulum stress in tauopathy.
Biochemical and biophysical research communications
Sakagami Y,Kudo T,Tanimukai H,Kanayama D,Omi T,Horiguchi K,Okochi M,Imaizumi K,Takeda M
MA5-15738 was used in western blot to study the involvement of endoplasmic reticulum stress in tauopathy
Fri Jan 11 00:00:00 EST 2013
c-di-GMP signaling regulates E. coli O157:H7 adhesion to colonic epithelium.
Veterinary microbiology
Hu J,Wang B,Fang X,Means WJ,McCormick RJ,Gomelsky M,Zhu MJ
MA5-15738 was used in western blot to investigate the role of c-di-GMP signaling in cattle gut colonization of E. coli O157:H7
Fri Jun 28 00:00:00 EDT 2013
Local injection of lentivirus encoding LINGO-1-shRNA promotes functional recovery in rats with complete spinal cord transection.
Spine
Cen J,Wu H,Wang J,Ren X,Zhang H,Wang J,Wan Y,Deng Y
MA5-15738 was used in western blot to evaluate the effects of LINGO-1 shRNA injection on spinal cord injury
Sun Sep 01 00:00:00 EDT 2013
Over-expression of the overexpressed in lung cancer 1 is associated with poor prognosis in epithelial ovarian cancer.
Journal of surgical oncology
Jia C,Li X,Sun H,Sui L
MA5-15738 was used in western blot to study the prognostic significance of OCL-1 overexpression in epithelial ovarian cancer
Sat Jun 01 00:00:00 EDT 2013
Effect of beta-carotene on oxidative stress and expression of cardiac connexin 43.
Arquivos brasileiros de cardiologia
Novo R,Azevedo PS,Minicucci MF,Zornoff LA,Paiva SA
MA5-15738 was used in western blot to study the effects of dietary supplementation with beta-carotene on markers of oxidative stress and cardiac expression of connexin-43 in rats
Sun Sep 01 00:00:00 EDT 2013
Glutamate acid decarboxylase 1 promotes metastasis of human oral cancer by β-catenin translocation and MMP7 activation.
BMC cancer
Kimura R,Kasamatsu A,Koyama T,Fukumoto C,Kouzu Y,Higo M,Endo-Sakamoto Y,Ogawara K,Shiiba M,Tanzawa H,Uzawa K
MA5-15738 was used in western blot to investigate the role of GAD1 in human oral cancer
Thu Nov 21 00:00:00 EST 2013
Active inhibitor-1 maintains protein hyper-phosphorylation in aging hearts and halts remodeling in failing hearts.
PloS one
Pritchard TJ,Kawase Y,Haghighi K,Anjak A,Cai W,Jiang M,Nicolaou P,Pylar G,Karakikes I,Rapti K,Rubinstein J,Hajjar RJ,Kranias EG
MA5-15738 was used in western blot to assess the effects of constitutive expression of active inhibitor-1 in the heart
Mon Aug 18 00:00:00 EDT 2014
Comparison of first dimension IPG and NEPHGE techniques in two-dimensional gel electrophoresis experiment with cytosolic unfolded protein response in Saccharomyces cerevisiae.
Proteome science
Slibinskas R,Ražanskas R,Zinkevičiūtė R,Čiplys E
MA5-15738 was used in Western Blotting to directly compare IPG-based and non-equilibrium pH gradient electrophoresis-based 2DE techniques by using the same samples and identical second dimension procedures.
Sat Jul 27 00:00:00 EDT 2013
Growth and differentiation factor 3 induces expression of genes related to differentiation in a model of cancer stem cells and protects them from retinoic acid-induced apoptosis.
PloS one
Tykwinska K,Lauster R,Knaus P,Rosowski M
MA5-15738 was used in western blot to clarify the role of GDF3 in an in vitro model of cancer stem cells
Thu Mar 06 00:00:00 EST 2014
Abnormal calcium cycling and cardiac arrhythmias associated with the human Ser96Ala genetic variant of histidine-rich calcium-binding protein.
Journal of the American Heart Association
Singh VP,Rubinstein J,Arvanitis DA,Ren X,Gao X,Haghighi K,Gilbert M,Iyer VR,Kim DH,Cho C,Jones K,Lorenz JN,Armstrong CF,Wang HS,Gyorke S,Kranias EG
MA5-15738 was used in western blot to study how the Ser96A1a variant contributes to arrhythmias
Mon Oct 14 00:00:00 EDT 2013
AT13148 is a novel, oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity.
Clinical cancer research : an official journal of the American Association for Cancer Research
Yap TA,Walton MI,Grimshaw KM,Te Poele RH,Eve PD,Valenti MR,de Haven Brandon AK,Martins V,Zetterlund A,Heaton SP,Heinzmann K,Jones PS,Feltell RE,Reule M,Woodhead SJ,Davies TG,Lyons JF,Raynaud FI,Eccles SA,Workman P,Thompson NT,Garrett MD
MA5-15738 was used in western blot to study the pharmacodynamics and anti-tumor activity of a novel orally bioavailable inhibitor targeting mutiple AGC kinases
Sun Jul 15 00:00:00 EDT 2012
Prognostic impact of Raf-1 and p-Raf-1 expressions for poor survival rate in non-small cell lung cancer.
Cancer science
Qiu ZX,Wang L,Han J,Liu D,Huang W,Altaf K,Qiu XS,Javed MA,Zheng J,Chen BJ,Li WM
MA5-15738 was used in western blot to study the prognostic value of Raf-1 and p-Raf-1 expression in non-small cell lung cancer
Mon Oct 01 00:00:00 EDT 2012
Gravity-sensitive signaling drives 3-dimensional formation of multicellular thyroid cancer spheroids.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Grosse J,Wehland M,Pietsch J,Schulz H,Saar K,Hübner N,Eilles C,Bauer J,Abou-El-Ardat K,Baatout S,Ma X,Infanger M,Hemmersbach R,Grimm D
MA5-15738 was used in western blot to evaluate signaling elements involved in 3D MTCS formation
Sat Dec 01 00:00:00 EST 2012
Side-stream smoking reduces intestinal inflammation and increases expression of tight junction proteins.
World journal of gastroenterology
Wang H,Zhao JX,Hu N,Ren J,Du M,Zhu MJ
MA5-15738 was used in western blot to investigate the effects of side-stream smoking on gut microflora, intestinal inflammation and expression of tight junction proteins
Mon May 14 00:00:00 EDT 2012
In vitro and in vivo evaluations on osteogenesis and biodegradability of a β-tricalcium phosphate coated magnesium alloy.
Journal of biomedical materials research. Part A
Chai H,Guo L,Wang X,Gao X,Liu K,Fu Y,Guan J,Tan L,Yang K
MA5-15738 was used in western blot to study the effects on osteogenesis and biodegradation of coating a magnesium alloy with beta-tricalcium phosphate and the significance for orthopedic implantation
Wed Feb 01 00:00:00 EST 2012
In vivo, cardiac-specific knockdown of a target protein, malic enzyme-1, in rat via adenoviral delivery of DNA for non-native miRNA.
Current gene therapy
O'Donnell JM,Kalichira A,Bi J,Lewandowski ED
MA5-15738 was used in western blot to assess the feasibility of adenoviral DNA delivery to knockdown a target protein
Sat Dec 01 00:00:00 EST 2012
Hypothyroidism reduces ObRb-STAT3 leptin signalling in the hypothalamus and pituitary of rats associated with resistance to leptin acute anorectic action.
The Journal of endocrinology
Calvino C,Souza LL,Costa-e-Sousa RH,Almeida NA,Trevenzoli IH,Pazos-Moura CC
MA5-15738 was used in western blot to evaluate leptin signaling via the STAT3 pathway
Mon Oct 01 00:00:00 EDT 2012
The use of sigmoid pH gradients in free-flow isoelectric focusing of human endothelial cell proteins.
Electrophoresis
Ma X,Wildgruber R,Bauer J,Weber G,Infanger M,Grosse J,Grimm D
MA5-15738 was used in western blot to improve free-flow isoelectric focusing through the use of sigmoid pH gradients
Tue May 01 00:00:00 EDT 2012
Menthol inhibits the proliferation and motility of prostate cancer DU145 cells.
Pathology oncology research : POR
Wang Y,Wang X,Yang Z,Zhu G,Chen D,Meng Z
MA5-15738 was used in western blot to study the effects of TRPM8 activation on prostate cancer cell proliferation and migration
Mon Oct 01 00:00:00 EDT 2012
Glucocorticoids augment survival and proliferation of tumor cells.
Anticancer research
Gündisch S,Boeckeler E,Behrends U,Amtmann E,Ehrhardt H,Jeremias I
MA5-15738 was used in western blot to investigate the effects of glucocorticoids on tumor cells
Mon Oct 01 00:00:00 EDT 2012
Oral administration of GW788388, an inhibitor of transforming growth factor beta signaling, prevents heart fibrosis in Chagas disease.
PLoS neglected tropical diseases
de Oliveira FL,Araújo-Jorge TC,de Souza EM,de Oliveira GM,Degrave WM,Feige JJ,Bailly S,Waghabi MC
MA5-15738 was used in western blot to study the effects of the TGF? inhibitor GW788388 in Chagas disease
Fri Sep 28 00:00:00 EDT 2012
Histone deacetylase inhibitors induce epithelial-to-mesenchymal transition in prostate cancer cells.
PloS one
Kong D,Ahmad A,Bao B,Li Y,Banerjee S,Sarkar FH
MA5-15738 was used in western blot to examine the role of HDAC inhibitors in EMT in prostate cancer cells
Fri Feb 15 00:00:00 EST 2013
Comparative effects of liensinine and neferine on the human ether-a-go-go-related gene potassium channel and pharmacological activity analysis.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Dong ZX,Zhao X,Gu DF,Shi YQ,Zhang J,Hu XX,Hu MQ,Yang BF,Li BX
MA5-15738 was used in western blot to investigate the effects of liensinine and neferine on the hERG channel
Thu Aug 09 00:00:00 EDT 2012
Epigenetic silencing of miR-34a in human prostate cancer cells and tumor tissue specimens can be reversed by BR-DIM treatment.
American journal of translational research
Kong D,Heath E,Chen W,Cher M,Powell I,Heilbrun L,Li Y,Ali S,Sethi S,Hassan O,Hwang C,Gupta N,Chitale D,Sakr WA,Menon M,Sarkar FH
MA5-15738 was used in western blot to investigate the transcriptional and functional regulation of the androgen receptor in prostate cancer
Tue Oct 02 00:00:00 EDT 2012
Munc18-1 regulates first-phase insulin release by promoting granule docking to multiple syntaxin isoforms.
The Journal of biological chemistry
Oh E,Kalwat MA,Kim MJ,Verhage M,Thurmond DC
MA5-15738 was used in western blot to study how Munc18-1 facilitates insulin secretion
Fri Jul 27 00:00:00 EDT 2012
Loss of let-7 up-regulates EZH2 in prostate cancer consistent with the acquisition of cancer stem cell signatures that are attenuated by BR-DIM.
PloS one
Kong D,Heath E,Chen W,Cher ML,Powell I,Heilbrun L,Li Y,Ali S,Sethi S,Hassan O,Hwang C,Gupta N,Chitale D,Sakr WA,Menon M,Sarkar FH
MA5-15738 was used in western blot to investigate the mechanism by which let-7 increases aggressiveness of prostate cancer
Mon Jul 23 00:00:00 EDT 2012
Role of checkpoint kinase 1 (Chk1) in the mechanisms of resistance to histone deacetylase inhibitors.
Proceedings of the National Academy of Sciences of the United States of America
Lee JH,Choy ML,Ngo L,Venta-Perez G,Marks PA
MA5-15738 was used in western blot to study the functions of checkpoint kinase 1
Tue Dec 06 00:00:00 EST 2011
Functional duality of astrocytes in myelination.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Nash B,Thomson CE,Linington C,Arthur AT,McClure JD,McBride MW,Barnett SC
MA5-15738 was used in western blot to study the role of astrocytes in myelination
Wed Sep 14 00:00:00 EDT 2011
A novel luciferase and GFP dual reporter virus for rapid and convenient evaluation of hepatitis C virus replication.
Virus research
Wu Y,Liao Q,Yang R,Chen X,Chen X
MA5-15738 was used in western blot to develop a dual luciferase-GFP reporter virus to study HCV replication
Tue Feb 01 00:00:00 EST 2011
Presynaptic stimulus-release and postsynaptic compensatory changes in mice lacking the N-type calcium channel α(1B)-subunit.
Autonomic neuroscience : basic & clinical
Petrashevskaya NN,Ishii M,D'Souza K,Koch SE,Fuller-Bicer GA,Schwartz A
MA5-15738 was used in western blot to investigate the influence of specific voltage-dependent calcium channel deletion on synaptic function
Thu Feb 24 00:00:00 EST 2011
HSPB1, HSPB6, HSPB7 and HSPB8 protect against RhoA GTPase-induced remodeling in tachypaced atrial myocytes.
PloS one
Ke L,Meijering RA,Hoogstra-Berends F,Mackovicova K,Vos MJ,Van Gelder IC,Henning RH,Kampinga HH,Brundel BJ
MA5-15738 was used in western blot to examine the protective effect of the HSPB family on tachycardia remodeling
Wed Nov 02 00:00:00 EDT 2011
The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice.
The Journal of clinical investigation
Greenblatt MB,Shim JH,Zou W,Sitara D,Schweitzer M,Hu D,Lotinun S,Sano Y,Baron R,Park JM,Arthur S,Xie M,Schneider MD,Zhai B,Gygi S,Davis R,Glimcher LH
MA5-15738 was used in western blot to investigate the role of p38 signaling in the regulation of bone development and homeostasis
Thu Jul 01 00:00:00 EDT 2010
Selective inhibition of histone deacetylase 6 (HDAC6) induces DNA damage and sensitizes transformed cells to anticancer agents.
Proceedings of the National Academy of Sciences of the United States of America
Namdar M,Perez G,Ngo L,Marks PA
MA5-15738 was used in western blot to study the effects of selective inhibition of HDAC6
Tue Nov 16 00:00:00 EST 2010
Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair.
Proceedings of the National Academy of Sciences of the United States of America
Lee JH,Choy ML,Ngo L,Foster SS,Marks PA
MA5-15738 was used in western blot to study the tumor selective action of HDACi
Tue Aug 17 00:00:00 EDT 2010
Ca(2+)/calmodulin-dependent protein kinase II contributes to intracellular pH recovery from acidosis via Na(+)/H(+) exchanger activation.
Journal of molecular and cellular cardiology
Vila-Petroff M,Mundiña-Weilenmann C,Lezcano N,Snabaitis AK,Huergo MA,Valverde CA,Avkiran M,Mattiazzi A
MA5-15738 was used in western blot to determine whether CaMKII activates the Na(+)/H(+) exchanger
Thu Jul 01 00:00:00 EDT 2010
Induction of glucocorticoid receptor-beta expression in epithelial cells of asthmatic airways by T-helper type 17 cytokines.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Vazquez-Tello A,Semlali A,Chakir J,Martin JG,Leung DY,Eidelman DH,Hamid Q
MA5-15738 was used in western blot to investigate the effect of interleukin 17 on glucocorticoid receptor beta level in epithelial cells from asthmatic patients
Wed Sep 01 00:00:00 EDT 2010
Application of free-flow IEF to identify protein candidates changing under microgravity conditions.
Proteomics
Pietsch J,Kussian R,Sickmann A,Bauer J,Weber G,Nissum M,Westphal K,Egli M,Grosse J,Schönberger J,Wildgruber R,Infanger M,Grimm D
MA5-15738 was used in western blot to identify gravity-sensitive protein expression with free-flow IEF
Mon Mar 01 00:00:00 EST 2010
Epithelial to mesenchymal transition is mechanistically linked with stem cell signatures in prostate cancer cells.
PloS one
Kong D,Banerjee S,Ahmad A,Li Y,Wang Z,Sethi S,Sarkar FH
MA5-15738 was used in western blot to investigate the similarities between epithelial to mesenchymal transition and cancer stem-like cells in prostate cancer cells
Fri Aug 27 00:00:00 EDT 2010
The integrin co-activator Kindlin-3 is expressed and functional in a non-hematopoietic cell, the endothelial cell.
The Journal of biological chemistry
Bialkowska K,Ma YQ,Bledzka K,Sossey-Alaoui K,Izem L,Zhang X,Malinin N,Qin J,Byzova T,Plow EF
MA5-15738 was used in western blot to investigate the expression of integrin co-activator Kindlin-3 in endothelial cells
Fri Jun 11 00:00:00 EDT 2010
Characterization of human chondrocytes exposed to simulated microgravity.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Ulbrich C,Westphal K,Pietsch J,Winkler HD,Leder A,Bauer J,Kossmehl P,Grosse J,Schoenberger J,Infanger M,Egli M,Grimm D
MA5-15738 was used in western blot to investigate the effect of simulated microgravity on chondrocyte characteristics
Mon Jun 21 00:00:00 EDT 2010
TAK1 is an essential regulator of BMP signalling in cartilage.
The EMBO journal
Shim JH,Greenblatt MB,Xie M,Schneider MD,Zou W,Zhai B,Gygi S,Glimcher LH
MA5-15738 was used in western blot to analyse the in vivo function of TAK1 in cartilage
Wed Jul 22 00:00:00 EDT 2009
Transcriptional activation of insulin-like growth factor binding protein 6 by 17beta-estradiol in SaOS-2 cells.
Experimental & molecular medicine
Zhao YY,Guo L,Zhao XJ,Liu H,Lei T,Ma DJ,Gao XY
MA5-15738 was used in western blot to study the induction of IGFBP6 by estrogen in a human osteoblastic-like cell line
Fri Jul 31 00:00:00 EDT 2009
The effects of repeated allergen challenge on airway smooth muscle structural and molecular remodeling in a rat model of allergic asthma.
American journal of physiology. Lung cellular and molecular physiology
Labonté I,Hassan M,Risse PA,Tsuchiya K,Laviolette M,Lauzon AM,Martin JG
MA5-15738 was used in western blot to study the effects of repeated allergen challenge in a rat model of allergic asthma
Thu Oct 01 00:00:00 EDT 2009
A citrus extract containing flavanones represses plasminogen activator inhibitor-1 (PAI-1) expression and regulates multiple inflammatory, tissue repair, and fibrosis genes in human colon fibroblasts.
Journal of agricultural and food chemistry
Giménez-Bastida JA,Martínez-Florensa M,Espín JC,Tomás-Barberán FA,García-Conesa MT
MA5-15738 was used in western blot to study the molecular mechanisms underlying the beneficial anti-inflammatory effects of citrus-derived flavanones on human colon fibroblasts
Wed Oct 14 00:00:00 EDT 2009
Dissimilar in vitro and in vivo effects of ellagic acid and its microbiota-derived metabolites, urolithins, on the cytochrome P450 1A1.
Journal of agricultural and food chemistry
González-Sarrías A,Azorín-Ortuño M,Yáñez-Gascón MJ,Tomás-Barberán FA,García-Conesa MT,Espín JC
MA5-15738 was used in western blot to examine the effects of ellagic acid and urolithins on the cytochrome P450 1A1
Wed Jun 24 00:00:00 EDT 2009
miR-200 regulates PDGF-D-mediated epithelial-mesenchymal transition, adhesion, and invasion of prostate cancer cells.
Stem cells (Dayton, Ohio)
Kong D,Li Y,Wang Z,Banerjee S,Ahmad A,Kim HR,Sarkar FH
MA5-15738 was used in western blot to study the role of miR-200 down-regulation in PDGF-D-induced prostate cancer cell epithelial-mesenchymal transition
Sat Aug 01 00:00:00 EDT 2009
The JNK pathway amplifies and drives subcellular changes in tau phosphorylation.
Neuropharmacology
Vogel J,Anand VS,Ludwig B,Nawoschik S,Dunlop J,Braithwaite SP
MA5-15738 was used in western blot to study the role of the JNK pathway in tau phosphorylation
Fri Dec 04 00:00:00 EST 2009
Effects of TRPM8 on the proliferation and motility of prostate cancer PC-3 cells.
Asian journal of andrology
Yang ZH,Wang XH,Wang HP,Hu LQ
MA5-15738 was used in western blot to study the effect of TRPM8 overexpression on prostate cancer cell proliferation and migration
Sun Mar 01 00:00:00 EST 2009
Platelet-derived growth factor-D overexpression contributes to epithelial-mesenchymal transition of PC3 prostate cancer cells.
Stem cells (Dayton, Ohio)
Kong D,Wang Z,Sarkar SH,Li Y,Banerjee S,Saliganan A,Kim HR,Cher ML,Sarkar FH
MA5-15738 was used in western blot to investigate whether PDGF-D overexpression contributes to epithelial-mesenchymal transition of cancer cells
Sun Jun 01 00:00:00 EDT 2008
Calpain mediates cardiac troponin degradation and contractile dysfunction in atrial fibrillation.
Journal of molecular and cellular cardiology
Ke L,Qi XY,Dijkhuis AJ,Chartier D,Nattel S,Henning RH,Kampinga HH,Brundel BJ
MA5-15738 was used in western blot to identify the proteases involved in degradation of myofibrillar proteins during atrial fibrillation
Sat Nov 01 00:00:00 EDT 2008
Effects of basic fibroblast growth factor on endothelial cells under conditions of simulated microgravity.
Journal of cellular biochemistry
Ulbrich C,Westphal K,Baatout S,Wehland M,Bauer J,Flick B,Infanger M,Kreutz R,Vadrucci S,Egli M,Cogoli A,Derradji H,Pietsch J,Paul M,Grimm D
MA5-15738 was used in western blot to examine the effects of basic FGF on endothelial cells under simulated microgravity
Tue Jul 01 00:00:00 EDT 2008
Vascular endothelial growth factor induces extracellular matrix proteins and osteopontin in the umbilical artery.
Annals of vascular surgery
Infanger M,Grosse J,Westphal K,Leder A,Ulbrich C,Paul M,Grimm D
MA5-15738 was used in western blot to study the effects of VEGF on healthy umbilical arteries
Sat Mar 01 00:00:00 EST 2008
Calcineurin in reactive astrocytes plays a key role in the interplay between proinflammatory and anti-inflammatory signals.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Fernandez AM,Fernandez S,Carrero P,Garcia-Garcia M,Torres-Aleman I
MA5-15738 was used in western blot to study the role of reactive astrocyte calcineurin in regulating pro- and anti-inflammatory signaling
Wed Aug 15 00:00:00 EDT 2007
Combination of peptide OFFGEL fractionation and label-free quantitation facilitated proteomics profiling of extraocular muscle.
Proteomics
Fraterman S,Zeiger U,Khurana TS,Rubinstein NA,Wilm M
MA5-15738 was used in western blot to optimise proteomics profiling of extraocular muscle using OFFGEL fractionation
Sat Sep 01 00:00:00 EDT 2007
Heart-specific inhibition of protooncogene c-myc attenuates cold-induced cardiac hypertrophy.
Gene therapy
Bello Roufai M,Li H,Sun Z
MA5-15738 was used in western blot to investigate the influence of c-myc inhibition in heart on heart hypertrophy treatment
Mon Oct 01 00:00:00 EDT 2007
Comparison of protective effects of trimetazidine against experimental warm ischemia of different durations: early and long-term effects in a pig kidney model.
American journal of physiology. Renal physiology
Jayle C,Favreau F,Zhang K,Doucet C,Goujon JM,Hebrard W,Carretier M,Eugene M,Mauco G,Tillement JP,Hauet T
MA5-15738 was used in western blot to investigate the effect of trimetazidine on experimental warm ischemia in a pig renal model
Thu Mar 01 00:00:00 EST 2007
Expression of vascular endothelial growth factor and receptor tyrosine kinases in cardiac ischemia/reperfusion injury.
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology
Infanger M,Faramarzi S,Grosse J,Kurth E,Ulbrich C,Bauer J,Wehland M,Kreutz R,Kossmehl P,Paul M,Grimm D
MA5-15738 was used in western blot to examine the expression of VEGF and receptor tyrosine kinases in cardiac ischemia/reperfusion injury
Thu Oct 25 00:00:00 EDT 2007
Induction of heat shock response protects the heart against atrial fibrillation.
Circulation research
Brundel BJ,Shiroshita-Takeshita A,Qi X,Yeh YH,Chartier D,van Gelder IC,Henning RH,Kampinga HH,Nattel S
MA5-15738 was used in western blot to evaluate the effect of heat shock protein induction in an in vitro atrial cell line
Fri Dec 08 00:00:00 EST 2006
Heat shock protein upregulation protects against pacing-induced myolysis in HL-1 atrial myocytes and in human atrial fibrillation.
Journal of molecular and cellular cardiology
Brundel BJ,Henning RH,Ke L,van Gelder IC,Crijns HJ,Kampinga HH
MA5-15738 was used in western blot to investigate the efficacy of heat shock proteins in preventing myolysis in atrial fibrillation
Fri Sep 01 00:00:00 EDT 2006
Reduced inotropic effect of nifekalant in failing hearts in rats.
The Journal of pharmacology and experimental therapeutics
Endo H,Miura M,Hirose M,Takahashi J,Nakano M,Wakayama Y,Sugai Y,Kagaya Y,Watanabe J,Shirato K,Shimokawa H
MA5-15738 was used in western blot to study the magnitude of the ionotropic effect of the Class III anti-arrhythmic agent Nifkalant in the failing rat heart
Fri Sep 01 00:00:00 EDT 2006
Calpain inhibition prevents pacing-induced cellular remodeling in a HL-1 myocyte model for atrial fibrillation.
Cardiovascular research
Brundel BJ,Kampinga HH,Henning RH
MA5-15738 was used in western blot to study the mechanisms underlying myocyte remodeling in atrial fibrillation
Tue Jun 01 00:00:00 EDT 2004
Increased expression of cardiac angiotensin II type 1 (AT(1)) receptors decreases myocardial microvessel density after experimental myocardial infarction.
Cardiovascular research
de Boer RA,Pinto YM,Suurmeijer AJ,Pokharel S,Scholtens E,Humler M,Saavedra JM,Boomsma F,van Gilst WH,van Veldhuisen DJ
MA5-15738 was used in western blot to study the effects of increased myocardial angiotensin II type 1 (AT(1)) receptor expression on microvascular growth
Sat Feb 01 00:00:00 EST 2003
LOT1 (PLAGL1/ZAC1), the candidate tumor suppressor gene at chromosome 6q24-25, is epigenetically regulated in cancer.
The Journal of biological chemistry
Abdollahi A,Pisarcik D,Roberts D,Weinstein J,Cairns P,Hamilton TC
MA5-15738 was used in western blot to study the epigenetic regulation of LOT1 tumor-suppressor expression in cancer
Fri Feb 21 00:00:00 EST 2003
Activation of proteolysis by calpains and structural changes in human paroxysmal and persistent atrial fibrillation.
Cardiovascular research
Brundel BJ,Ausma J,van Gelder IC,Van der Want JJ,van Gilst WH,Crijns HJ,Henning RH
MA5-15738 was used in western blot to study structural changes in human paroxysmal and persistent atrial fibrillation
Wed May 01 00:00:00 EDT 2002
Ion channel remodeling is related to intraoperative atrial effective refractory periods in patients with paroxysmal and persistent atrial fibrillation.
Circulation
Brundel BJ,Van Gelder IC,Henning RH,Tieleman RG,Tuinenburg AE,Wietses M,Grandjean JG,Van Gilst WH,Crijns HJ
MA5-15738 was used in western blot to investigate the molecular changes underlying atrial fibrillation
Tue Feb 06 00:00:00 EST 2001
Alterations in potassium channel gene expression in atria of patients with persistent and paroxysmal atrial fibrillation: differential regulation of protein and mRNA levels for K+ channels.
Journal of the American College of Cardiology
Brundel BJ,Van Gelder IC,Henning RH,Tuinenburg AE,Wietses M,Grandjean JG,Wilde AA,Van Gilst WH,Crijns HJ
MA5-15738 was used in western blot to study potassium channel gene expression in patients with atrial fibrillation
Thu Mar 01 00:00:00 EST 2001
