Product References
Using the Culex pipiens sperm proteome to identify elements essential for mosquito reproduction.
PloS one
Thaler CD,Carstens K,Martinez G,Stephens K,Cardullo RA
Published figure using ERK1/ERK2 polyclonal antibody (Product # 44-654G) in Western Blot
Wed Feb 22 00:00:00 EST 2023
Changes of RAS Pathway Phosphorylation in Lymphoblastoid Cell Lines from Noonan Syndrome Patients Carrying Hypomorphic Variants in Two NS Genes.
International journal of molecular sciences
Tritto V,Capitanio D,Gelfi C,Riva P
44-654G was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to suggest that the presence of one subclinical variant can activate the RAS pathway below the pathological threshold, which can instead be exceeded by the additive effect due to the co-presence of two subclinical variants causing NS, supporting our digenic inheritance hypothesis.
Fri Feb 17 00:00:00 EST 2023
Hematopoietic Cell Kinase (HCK) Is a Player of the Crosstalk Between Hematopoietic Cells and Bone Marrow Niche Through CXCL12/CXCR4 Axis.
Frontiers in cell and developmental biology
Roversi FM,Bueno MLP,Pericole FV,Saad STO
44-654G was used in Western Blot to study the role of one SFK member, the Hematopoietic Cell Kinase (HCK), in CXCL12/CXCR4 pathway and its contribution to the AML pathogenesis.
Tue Apr 13 00:00:00 EDT 2021
Hematopoietic Cell Kinase (HCK) Is a Player of the Crosstalk Between Hematopoietic Cells and Bone Marrow Niche Through CXCL12/CXCR4 Axis.
Frontiers in cell and developmental biology
Roversi FM,Bueno MLP,Pericole FV,Saad STO
44-654G was used in Western Blot to study the role of one SFK member, the Hematopoietic Cell Kinase (HCK), in CXCL12/CXCR4 pathway and its contribution to the AML pathogenesis.
Tue Apr 13 00:00:00 EDT 2021
Role of thiocyanate in the modulation of myeloperoxidase-derived oxidant induced damage to macrophages.
Redox biology
Guo C,Davies MJ,Hawkins CL
44-654G was used in Western Blotting to provide further insight into the cellular pathways by which SCN- could exert protective effects on supplementation to decrease the development of chronic inflammatory diseases, such as atherosclerosis.
Tue Sep 01 00:00:00 EDT 2020
Role of thiocyanate in the modulation of myeloperoxidase-derived oxidant induced damage to macrophages.
Redox biology
Guo C,Davies MJ,Hawkins CL
44-654G was used in Western Blotting to provide further insight into the cellular pathways by which SCN- could exert protective effects on supplementation to decrease the development of chronic inflammatory diseases, such as atherosclerosis.
Tue Sep 01 00:00:00 EDT 2020
ZO-1 protein is required for hydrogen peroxide to increase MDCK cell paracellular permeability in an ERK 1/2-dependent manner.
American journal of physiology. Cell physiology
Bilal S,Jaggi S,Janosevic D,Shah N,Teymour S,Voronina A,Watari J,Axis J,Amsler K
44-654G was used in Western Blotting to demonstrate that H2O2 increases MDCK cell paracellular permeability through activation of ERK 1/2.
Sat Sep 01 00:00:00 EDT 2018
Neonatal maternal deprivation impairs localized de novo activity-induced protein translation at the synapse in the rat hippocampus.
Bioscience reports
Ahmad F,Salahuddin M,Alsamman K,Herzallah HK,Al-Otaibi ST
44-654G was used in Western Blotting to elucidate the molecular mechanisms underlying the detrimental alterations in brain functions induced by early-life stress.
Fri Jun 29 00:00:00 EDT 2018
Development of MK-8353, an orally administered ERK1/2 inhibitor, in patients with advanced solid tumors.
JCI insight
Moschos SJ,Sullivan RJ,Hwu WJ,Ramanathan RK,Adjei AA,Fong PC,Shapira-Frommer R,Tawbi HA,Rubino J,Rush TS,Zhang D,Miselis NR,Samatar AA,Chun P,Rubin EH,Schiller J,Long BJ,Dayananth P,Carr D,Kirschmeier P,Bishop WR,Deng Y,Cooper A,Shipps GW,Moreno BH,Robert L,Ribas A,Flaherty KT
44-654G was used in Western Blotting to develop an orally bioavailable ERK inhibitor, and demonstrate its efficacy in patients with advanced solid tumours.
Thu Feb 22 00:00:00 EST 2018
Metformin exerts multitarget antileukemia activity in JAK2V617F-positive myeloproliferative neoplasms.
Cell death & disease
Machado-Neto JA,Fenerich BA,Scopim-Ribeiro R,Eide CA,Coelho-Silva JL,Dechandt CRP,Fernandes JC,Rodrigues Alves APN,Scheucher PS,Simões BP,Alberici LC,de Figueiredo Pontes LL,Tognon CE,Druker BJ,Rego EM,Traina F
Published figure using ERK1/ERK2 polyclonal antibody (Product # 44-654G) in Western Blot
Thu Feb 22 00:00:00 EST 2018
Hematopoietic cell kinase (HCK) is a potential therapeutic target for dysplastic and leukemic cells due to integration of erythropoietin/PI3K pathway and regulation of erythropoiesis: HCK in erythropoietin/PI3K pathway.
Biochimica et biophysica acta. Molecular basis of disease
Roversi FM,Pericole FV,Machado-Neto JA,da Silva Santos Duarte A,Longhini AL,Corrocher FA,Palodetto B,Ferro KP,Rosa RG,Baratti MO,Verjovski-Almeida S,Traina F,Molinari A,Botta M,Saad ST
44654G was used in western blot to characterize a new specific pharmacological hematopoietic cell kinase inhibitor
Wed Feb 01 00:00:00 EST 2017
WNK1 kinase balances T cell adhesion versus migration in vivo.
Nature immunology
Köchl R,Thelen F,Vanes L,Brazão TF,Fountain K,Xie J,Huang CL,Lyck R,Stein JV,Tybulewicz VL
Published figure using ERK1/ERK2 polyclonal antibody (Product # 44-654G) in Western Blot
Thu Sep 01 00:00:00 EDT 2016
WNK1 kinase balances T cell adhesion versus migration in vivo.
Nature immunology
Köchl R,Thelen F,Vanes L,Brazão TF,Fountain K,Xie J,Huang CL,Lyck R,Stein JV,Tybulewicz VL
Published figure using ERK1/ERK2 polyclonal antibody (Product # 44-654G) in Western Blot
Thu Sep 01 00:00:00 EDT 2016
Melanocytes Affect Nodal Expression and Signaling in Melanoma Cells: A Lesson from Pediatric Large Congenital Melanocytic Nevi.
International journal of molecular sciences
Margaryan NV,Gilgur A,Seftor EA,Purnell C,Arva NC,Gosain AK,Hendrix MJ,Strizzi L
44-654G was used in western blot to research pediatric large congenital melanocytic nevi to show melanocytes affect nodal expression and signaling in melanoma cells
Tue Mar 22 00:00:00 EDT 2016
Simultaneous Activation of Induced Heterodimerization between CXCR4 Chemokine Receptor and Cannabinoid Receptor 2 (CB2) Reveals a Mechanism for Regulation of Tumor Progression.
The Journal of biological chemistry
Coke CJ,Scarlett KA,Chetram MA,Jones KJ,Sandifer BJ,Davis AS,Marcus AI,Hinton CV
44-654G was used in western blot to determine a mechanism for regulation of tumor progression due to simultaneous activation of induced heterodimerization between cannabinoid receptor 2 (CB2) and CXCR4 chemokine receptor
Fri May 06 00:00:00 EDT 2016
Candidate tumor suppressor B-cell translocation gene 3 impedes neoplastic progression by suppression of AKT.
Cell death & disease
Cheng YC,Chen PH,Chiang HY,Suen CS,Hwang MJ,Lin TY,Yang HC,Lin WC,Lai PL,Shieh SY
44-654G was used in western blot to elucidate the tumor suppressor function of BTG3
Thu Jan 08 00:00:00 EST 2015
ANKHD1 silencing inhibits Stathmin 1 activity, cell proliferation and migration of leukemia cells.
Biochimica et biophysica acta
Machado-Neto JA,Lazarini M,Favaro P,de Melo Campos P,Scopim-Ribeiro R,Franchi Junior GC,Nowill AE,Lima PR,Costa FF,Benichou S,Olalla Saad ST,Traina F
44-654G was used in western blot to identify binding partners ANKHD1 in leukemia cells.
Sun Mar 01 00:00:00 EST 2015
Effects of a novel Nodal-targeting monoclonal antibody in melanoma.
Oncotarget
Strizzi L,Sandomenico A,Margaryan NV,Focà A,Sanguigno L,Bodenstine TM,Chandler GS,Reed DW,Gilgur A,Seftor EA,Seftor RE,Khalkhali-Ellis Z,Leonardi A,Ruvo M,Hendrix MJ
44-654G was used in western blot to assess the use of 3D1 mAb for treating Nodal expressing cancers.
Tue Oct 27 00:00:00 EDT 2015
Increased ERK and JNK activation and decreased ERK/JNK ratio are associated with long-term organ damage in patients with systemic lupus erythematosus.
Rheumatology (Oxford, England)
Bloch O,Amit-Vazina M,Yona E,Molad Y,Rapoport MJ
44-654G was used in western blot to test if extracellular signal-regulated kinase and c-Jun N-terminal kinase are associated with long-term organ damage in SLE patients.
Sun Jun 01 00:00:00 EDT 2014
Silver and fullerene nanoparticles' effect on interleukin-2-dependent proliferation of CD4 (+) T cells.
Toxicology in vitro : an international journal published in association with BIBRA
Côté-Maurais G,Bernier J
44-654G was used in western blot to determine if nanoparticles inhibit IL-2-dependent T cell proliferation.
Mon Dec 01 00:00:00 EST 2014
Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression.
The Journal of cell biology
Lim ST,Miller NL,Chen XL,Tancioni I,Walsh CT,Lawson C,Uryu S,Weis SM,Cheresh DA,Schlaepfer DD
Published figure using ERK1/ERK2 polyclonal antibody (Product # 44-654G) in Western Blot
Mon Jun 25 00:00:00 EDT 2012
Lyn is a redox sensor that mediates leukocyte wound attraction in vivo.
Nature
Yoo SK,Starnes TW,Deng Q,Huttenlocher A
44-654G was used in western blot to identify Lyn as a redox sensor that recruits neutrophils to wounds in zebrafish larvae.
Sun Nov 20 00:00:00 EST 2011
Increased ERK and JNK activities correlate with disease activity in patients with systemic lupus erythematosus.
Annals of the rheumatic diseases
Molad Y,Amit-Vasina M,Bloch O,Yona E,Rapoport MJ
44-654G was used in western blot to discuss the contribution of the p21ras/MAP kinase pathway to systemic lupus erythematosus
Fri Jan 01 00:00:00 EST 2010
Alternative modes of GM-CSF receptor activation revealed using activated mutants of the common beta-subunit.
Blood
Perugini M,Brown AL,Salerno DG,Booker GW,Stojkoski C,Hercus TR,Lopez AF,Hibbs ML,Gonda TJ,D'Andrea RJ
Thu Apr 22 00:00:00 EDT 2010
Alternative modes of GM-CSF receptor activation revealed using activated mutants of the common beta-subunit.
Blood
Perugini M,Brown AL,Salerno DG,Booker GW,Stojkoski C,Hercus TR,Lopez AF,Hibbs ML,Gonda TJ,D'Andrea RJ
Thu Apr 22 00:00:00 EDT 2010
The absence of caveolin-1 increases proliferation and anchorage- independent growth by a Rac-dependent, Erk-independent mechanism.
Molecular and cellular biology
Cerezo A,Guadamillas MC,Goetz JG,Sánchez-Perales S,Klein E,Assoian RK,del Pozo MA
44-654G was used in western blot to elucidate the mechanisms by which loss of Cav1 function promotes cancer cell growth
Tue Sep 01 00:00:00 EDT 2009
Molecular mechanisms involved in interleukin-4-induced human neutrophils: expression and regulation of suppressor of cytokine signaling.
Journal of leukocyte biology
Ratthé C,Pelletier M,Chiasson S,Girard D
Tue May 01 00:00:00 EDT 2007
The mitogen-activated protein kinases (MAPK) p38 and JNK are markers of tumor progression in breast carcinoma.
Gynecologic oncology
Davidson B,Konstantinovsky S,Kleinberg L,Nguyen MT,Bassarova A,Kvalheim G,Nesland JM,Reich R
Fri Sep 01 00:00:00 EDT 2006
Phospho-caveolin-1 mediates integrin-regulated membrane domain internalization.
Nature cell biology
del Pozo MA,Balasubramanian N,Alderson NB,Kiosses WB,Grande-García A,Anderson RG,Schwartz MA
Thu Sep 01 00:00:00 EDT 2005
Phospho-caveolin-1 mediates integrin-regulated membrane domain internalization.
Nature cell biology
del Pozo MA,Balasubramanian N,Alderson NB,Kiosses WB,Grande-García A,Anderson RG,Schwartz MA
Thu Sep 01 00:00:00 EDT 2005
TNF-alpha promotes a stop signal that inhibits neutrophil polarization and migration via a p38 MAPK pathway.
Journal of leukocyte biology
Lokuta MA,Huttenlocher A
Fri Jul 01 00:00:00 EDT 2005
Matrix metalloproteinases (MMP), EMMPRIN (extracellular matrix metalloproteinase inducer) and mitogen-activated protein kinases (MAPK): co-expression in metastatic serous ovarian carcinoma.
Clinical & experimental metastasis
Davidson B,Givant-Horwitz V,Lazarovici P,Risberg B,Nesland JM,Trope CG,Schaefer E,Reich R
Thu Dec 18 00:00:00 EST 2003
