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Product Details
PA5-19893
Species Reactivity
Host/Isotype
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Type
Immunogen
Conjugate
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Product Specific Information
In Western blot applications, this antibody detects a band at ~115-130kDa. A suggested positive control is K562 cell lysate.
Target Information
APAF1 gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: APAF-1; apoptotic protease activating factor 1; Apoptotic protease-activating factor 1; DKFZp781B1145; forebrain overgrowth
Gene Aliases: 6230400I06Rik; APAF-1; APAF1; Apaf1l; CED4; fog; KIAA0413; mKIAA0413
UniProt ID: (Human) O14727, (Rat) Q9EPV5, (Mouse) O88879
Entrez Gene ID: (Human) 317, (Rat) 78963, (Mouse) 11783
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