Product References
Genetic associations of protein-coding variants in human disease.
Nature
Sun BB,Kurki MI,Foley CN,Mechakra A,Chen CY,Marshall E,Wilk JB,Chahine M,Chevalier P,Christé G,Palotie A,Daly MJ,Runz H
R910-25 was used in Western Blot to provide a compendium of protein-coding variant associations for future insights into disease biology and drug discovery.
Tue Mar 01 00:00:00 EST 2022
A micellized bone morphogenetic protein-7 prodrug ameliorates liver fibrosis by suppressing transforming growth factor-β signaling.
American journal of cancer research
Cho K,Kim NH,Seo SH,Song SH,Jeong CH,Kim HS,Um JE,Ku M,Yang J,Park JY,Ahn SH,Yook JI,Kim SU
R910-25 was used in Immunocytochemistry to study the ability of a micelle formulation consisting of a protein transduction domain fused BMP-7 polypeptide to enhance endocytic delivery and ameliorate liver fibrosis.
Thu Mar 10 00:00:00 EST 2022
The Ets protein Pointed P1 represses Asense expression in type II neuroblasts by activating Tailless.
PLoS genetics
Chen R,Deng X,Zhu S
R910-25 was used in Gel Shift to show that transcription factor pointed P1 (PntP1) functions as a transcriptional activator to indirectly suppress Ase expression in type II neuroblasts by activating the expression of the transcriptional repressor Tailless.
Sat Jan 01 00:00:00 EST 2022
CUGBP1, a crucial factor for heart regeneration in mice.
Cell death & disease
Liu Y,Wang H,Zhang H,Wang J,Liu Q,Bi Y,Song S,Qiao X,Zhu K,Wu Y,Ji G
R910-25 was used in Western Blot to support CUGBP1 as a key factor promoting post-injury heart regeneration and provide a potential therapeutic method for heart disease.
Tue Feb 08 00:00:00 EST 2022
An acquired phosphatidylinositol 4-phosphate transport initiates T-cell deterioration and leukemogenesis.
Nature communications
Zhong W,Lin W,Yang Y,Chen D,Cao X,Xu M,Pan G,Chen H,Zheng J,Feng X,Yang LH,Lai C,Olkkonen VM,Xu J,Cui S,Yan D
R910-25 was used in Western Blotting to identify a non-vesicular lipid transport machinery between Golgi and plasma membrane maintaining the oncogenic signaling competence initiating T-cell deterioration and leukemogenesis.
Fri Jul 29 00:00:00 EDT 2022
FK506-binding protein-like and FK506-binding protein 8 regulate dual leucine zipper kinase degradation and neuronal responses to axon injury.
The Journal of biological chemistry
Lee B,Oh Y,Cho E,DiAntonio A,Cavalli V,Shin JE,Choi HW,Cho Y
R910-25 was used in Western Blot to investigate the molecular mechanism of DLK function in response to neuronal injury.
Tue Mar 01 00:00:00 EST 2022
LARP1 isoform expression in human cancer cell lines.
RNA biology
Schwenzer H,Abdel Mouti M,Neubert P,Morris J,Stockton J,Bonham S,Fellermeyer M,Chettle J,Fischer R,Beggs AD,Blagden SP
R910-25 was used in Immunoprecipitation to observe that SI-LARP1 (NM_015315.5> NP_056130.2) is epigenetically repressed and that this repression is evolutionarily conserved in all but a small subclade of mammalian species.
Mon Feb 01 00:00:00 EST 2021
Opposing roles of E3 ligases TRIM23 and TRIM21 in regulation of ion channel ANO1 protein levels.
The Journal of biological chemistry
Cao X,Zhou Z,Tian Y,Liu Z,Cheng KO,Chen X,Hu W,Wong YM,Li X,Zhang H,Hu R,Huang P
R910-25 was used in Western Blot to show that both TRIM23 and TRIM21 physically interact with ANO1, and, that TRIM23 ubiquitinates and thereby stabilizes ANO1, whereas TRIM21 ubiquitinates and causes ANO1 degradation.
Tue Aug 31 00:00:00 EDT 2021
Regulation of the endocytosis and prion-chaperoning machineries by yeast E3 ubiquitin ligase Rsp5 as revealed by orthogonal ubiquitin transfer.
Cell chemical biology
Wang Y,Fang S,Chen G,Ganti R,Chernova TA,Zhou L,Duong D,Kiyokawa H,Li M,Zhao B,Shcherbik N,Chernoff YO,Yin J
R910-25 was used in ELISA, Immunocytochemistry, Immunoprecipitation, Western Blot to demonstrate the capacity of OUT to deconvolute the complex E3-substrate relationships in crucial biological processes such as endocytosis and protein assembly disorders through protein ubiquitination.
Thu Sep 16 00:00:00 EDT 2021
Protein phosphatase PPM1B inhibits DYRK1A kinase through dephosphorylation of pS258 and reduces toxic tau aggregation.
The Journal of biological chemistry
Lee YH,Im E,Hyun M,Park J,Chung KC
R910-25 was used in Western Blotting to investigate DYRK1A interactions in Down syndrome.
Tue Aug 24 00:00:00 EDT 2021
Spatial Multiplexing of Fluorescent Reporters for Imaging Signaling Network Dynamics.
Cell
Linghu C,Johnson SL,Valdes PA,Shemesh OA,Park WM,Park D,Piatkevich KD,Wassie AT,Liu Y,An B,Barnes SA,Celiker OT,Yao CC,Yu CJ,Wang R,Adamala KP,Bear MF,Keating AE,Boyden ES
R910-25 was used in Immunocytochemistry to create SiRIs for indicators of second messengers and kinases and used them, in hippocampal neurons in culture and intact brain slices, to discover relationships between the speed of calcium signaling, and the amplitude of PKA signaling, upon receiving a cAMP-driving stimulus.
Thu Dec 10 00:00:00 EST 2020
Tbx2a Modulates Switching of RH2 and LWS Opsin Gene Expression.
Molecular biology and evolution
Sandkam BA,Campello L,O'Brien C,Nandamuri SP,Gammerdinger WJ,Conte MA,Swaroop A,Carleton KL
R910-25 was used in Western Blotting to identify a role for the transcription factor Tbx2a in driving a switch between long wavelength sensitive (LWS) and Rhodopsin-like (RH2) opsin expression.
Wed Jul 01 00:00:00 EDT 2020
Differential expression of serum amyloid A1 and A3 in bovine epithelia.
The Journal of veterinary medical science
Murata E,Kozaki S,Murakami T,Shimizu K,Okada A,Ishiguro N,Inoshima Y
R910-25 was used in Western Blotting to produce a novel anti-bovine SAA3 monoclonal antibody. SAA3 expression levels in bovine epithelia were examined in vitro and in vivo using real-time PCR and immunohistochemistry (IHC).
Wed Jun 24 00:00:00 EDT 2020
Calcium-stimulated disassembly of focal adhesions mediated by an ORP3/IQSec1 complex.
eLife
D'Souza RS,Lim JY,Turgut A,Servage K,Zhang J,Orth K,Sosale NG,Lazzara MJ,Allegood J,Casanova JE
R910-25 was used in Western Blotting to identify a new pathway that links calcium influx to focal adhesion (FA) turnover during cell migration.
Wed Apr 01 00:00:00 EDT 2020
PHF7 Modulates BRDT Stability and Histone-to-Protamine Exchange during Spermiogenesis.
Cell reports
Kim CR,Noda T,Kim H,Kim G,Park S,Na Y,Oura S,Shimada K,Bang I,Ahn JY,Kim YR,Oh SK,Choi HJ,Kim JS,Jung I,Lee H,Okada Y,Ikawa M,Baek SH
R910-25 was used in Western Blotting to identify PHD finger protein 7 (PHF7) as an E3 ubiquitin ligase for histone H3K14 in post-meiotic spermatids.
Tue Jul 28 00:00:00 EDT 2020
RhoGDIβ affects HeLa cell spindle orientation following UVC irradiation.
Journal of cellular physiology
Doi N,Kunimatsu Y,Fujiura K,Togari H,Minagi K,Nakaoji K,Hamada K,Temme A,Tatsuka M
R910-25 was used in Western Blotting to reveal that RhoGDIβ impacts spindle orientation in response to DNA damage.
Sun Sep 01 00:00:00 EDT 2019
Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.
Structure (London, England : 1993)
Teyra J,Singer AU,Schmitges FW,Jaynes P,Kit Leng Lui S,Polyak MJ,Fodil N,Krieger JR,Tong J,Schwerdtfeger C,Brasher BB,Ceccarelli DFJ,Moffat J,Sicheri F,Moran MF,Gros P,Eichhorn PJA,Lenter M,Boehmelt G,Sidhu SS
R910-25 was used in Western Blot to develop ubiquitin variants (UbVs) that targeted either the catalytic domain or each of three adaptor domains in USP15, including the N-terminal DUSP domain.
Tue Apr 02 00:00:00 EDT 2019
Hectd3 promotes pathogenic Th17 lineage through Stat3 activation and Malt1 signaling in neuroinflammation.
Nature communications
Cho JJ,Xu Z,Parthasarathy U,Drashansky TT,Helm EY,Zuniga AN,Lorentsen KJ,Mansouri S,Cho JY,Edelmann MJ,Duong DM,Gehring T,Seeholzer T,Krappmann D,Uddin MN,Califano D,Wang RL,Jin L,Li H,Lv D,Zhou D,Zhou L,Avram D
R910-25 was used in Immunoprecipitation to delineate a mechanism connecting signalling related polyubiquitination of Malt1 and Stat3, leading to NF-kB activation and RORγt expression, to pathogenic Th17 cell function in experimental autoimmune encephalitis.
Mon Feb 11 00:00:00 EST 2019
The E3 ligases Itch and WWP2 cooperate to limit TH2 differentiation by enhancing signaling through the TCR.
Nature immunology
Aki D,Li H,Zhang W,Zheng M,Elly C,Lee JH,Zou W,Liu YC
R910-25 was used in Western Blotting to indicate that targeted ubiquitination regulates the strength of the TCR signal and differentiation toward the TH2 lineage.
Sun Jul 01 00:00:00 EDT 2018
RSK2 is required for TRAF6 phosphorylation-mediated colon inflammation.
Oncogene
Yao K,Lee SY,Peng C,Lim DY,Yamamoto H,Ryu J,Lim TG,Chen H,Jin G,Zhao Z,Han Y,Ma WY,Bode AM,Dong Z
R910-25 was used in Western Blotting to indicate that phosphorylation of TRAF6 by RSK2 is required for TRAF6 K63 ubiquitination and inflammation signalling.
Fri Jun 01 00:00:00 EDT 2018
RSK2 is required for TRAF6 phosphorylation-mediated colon inflammation.
Oncogene
Yao K,Lee SY,Peng C,Lim DY,Yamamoto H,Ryu J,Lim TG,Chen H,Jin G,Zhao Z,Han Y,Ma WY,Bode AM,Dong Z
R910-25 was used in Western Blotting to indicate that phosphorylation of TRAF6 by RSK2 is required for TRAF6 K63 ubiquitination and inflammation signalling.
Fri Jun 01 00:00:00 EDT 2018
ABHD5 stimulates PNPLA1-mediated ω-O-acylceramide biosynthesis essential for a functional skin permeability barrier.
Journal of lipid research
Kien B,Grond S,Haemmerle G,Lass A,Eichmann TO,Radner FPW
R910-25 was used in Western Blotting to identify ABHD5 as a coactivator of patatin-like phospholipase domain-containing 1 that stimulates the esterification of ω-hydroxy ceramides with linoleic acid for ω-O-acylceramide biosynthesis.
Sat Dec 01 00:00:00 EST 2018
SKP2- and OTUD1-regulated non-proteolytic ubiquitination of YAP promotes YAP nuclear localization and activity.
Nature communications
Yao F,Zhou Z,Kim J,Hang Q,Xiao Z,Ton BN,Chang L,Liu N,Zeng L,Wang W,Wang Y,Zhang P,Hu X,Su X,Liang H,Sun Y,Ma L
R910-25 was used in Western Blotting to report that YAP is subject to non-proteolytic, K63-linked polyubiquitination by the SCFSKP2 E3 ligase complex and reversed by the deubiquitinase OTUD1.
Mon Jun 11 00:00:00 EDT 2018
The Legionella pneumophila effector Ceg4 is a phosphotyrosine phosphatase that attenuates activation of eukaryotic MAPK pathways.
The Journal of biological chemistry
Quaile AT,Stogios PJ,Egorova O,Evdokimova E,Valleau D,Nocek B,Kompella PS,Peisajovich S,Yakunin AF,Ensminger AW,Savchenko A
R910-25 was used in Western Blotting to study the structural and functional features of the Legionella pneumophila effector protein, Ceg4.
Fri Mar 02 00:00:00 EST 2018
USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation.
Nature immunology
Torre S,Polyak MJ,Langlais D,Fodil N,Kennedy JM,Radovanovic I,Berghout J,Leiva-Torres GA,Krawczyk CM,Ilangumaran S,Mossman K,Liang C,Knobeloch KP,Healy LM,Antel J,Arbour N,Prat A,Majewski J,Lathrop M,Vidal SM,Gros P
R91025 was used in western blot to examine the contribution of USP15-TRIM25 to neuroinflammation
Sun Jan 01 00:00:00 EST 2017
TIEG1 modulates β-catenin sub-cellular localization and enhances Wnt signaling in bone.
Nucleic acids research
Subramaniam M,Cicek M,Pitel KS,Bruinsma ES,Nelson Holte MH,Withers SG,Rajamannan NM,Secreto FJ,Venuprasad K,Hawse JR
R910-25 was used in Western Blotting to provide evidence that TIEG1 is involved in regulating the canonical Wnt signaling pathway in bone through multiple mechanisms of action.
Fri May 19 00:00:00 EDT 2017
Ufd2p synthesizes branched ubiquitin chains to promote the degradation of substrates modified with atypical chains.
Nature communications
Liu C,Liu W,Ye Y,Li W
R910-25 was used in Western Blotting to suggest that yeast ubiquitin chain elongation factors E4, Ufd2p, functions by switching ubiquitin chain linkages to allow proteasome degradation of proteins modified with atypical ubiquitin linkage.
Mon Feb 06 00:00:00 EST 2017
The N-terminal region of serum amyloid A3 protein activates NF-κB and up-regulates MUC2 mucin mRNA expression in mouse colonic epithelial cells.
PloS one
Tashiro M,Iwata A,Yamauchi M,Shimizu K,Okada A,Ishiguro N,Inoshima Y
R910-25 was used in Western Blotting to examine the molecular mechanisms underlying the biological functions of serum amyloid A3 protein in mouse colonic epithelial cells.
Thu Sep 21 00:00:00 EDT 2017
Itch inhibits IL-17-mediated colon inflammation and tumorigenesis by ROR-γt ubiquitination.
Nature immunology
Kathania M,Khare P,Zeng M,Cantarel B,Zhang H,Ueno H,Venuprasad K
R910-25 was used in western blot to analyze inhibition of IL-17-mediated colon inflammation and tumorigenesis by ROR-gamma-t ubiquitination by Itch
Mon Aug 01 00:00:00 EDT 2016
Conformational Changes in Transmembrane Domain 4 of Presenilin 1 Are Associated with Altered Amyloid-β 42 Production.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Tominaga A,Cai T,Takagi-Niidome S,Iwatsubo T,Tomita T
R910-25 was used in western blot to analyze altered amyloid beta 42 production in conjunction with conformational changes in transmembrane domain 4 of presenilin 1
Wed Jan 27 00:00:00 EST 2016
Oxysterol binding protein-related protein 8 mediates the cytotoxicity of 25-hydroxycholesterol.
Journal of lipid research
Li J,Zheng X,Lou N,Zhong W,Yan D
R91025 was used in western blot to propose that ORP8 mediates the cytotoxicity of 25-hydroxycholesterol
Sat Oct 01 00:00:00 EDT 2016
CED-4 is an mRNA-binding protein that delivers ced-3 mRNA to ribosomes.
Biochemical and biophysical research communications
Wang MX,Itoh M,Li S,Hida Y,Ohta K,Hayakawa M,Nishida E,Ueda M,Islam S,Nakagawa T
R910-25 was used in western blot to analyze the role of CED-4 in delivering ced-3 mRNA to ribosomes
Fri Jan 29 00:00:00 EST 2016
TMEM119 marks a subset of microglia in the human brain.
Neuropathology : official journal of the Japanese Society of Neuropathology
Satoh J,Kino Y,Asahina N,Takitani M,Miyoshi J,Ishida T,Saito Y
R910-25 was used in western blot to report that TMEM119 distinguishes resident microglia from blood-derived macrophages
Mon Feb 01 00:00:00 EST 2016
Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis.
Nature communications
Kim Y,Nam HJ,Lee J,Park DY,Kim C,Yu YS,Kim D,Park SW,Bhin J,Hwang D,Lee H,Koh GY,Baek SH
R910-25 was used in Western Blotting to demonstrate a role for HIF-1α methylation in regulating protein stability, thereby modulating biological output including retinal and tumour angiogenesis.
Wed Jan 13 00:00:00 EST 2016
Diverse mechanisms of metaeffector activity in an intracellular bacterial pathogen, Legionella pneumophila.
Molecular systems biology
Urbanus ML,Quaile AT,Stogios PJ,Morar M,Rao C,Di Leo R,Evdokimova E,Lam M,Oatway C,Cuff ME,Osipiuk J,Michalska K,Nocek BP,Taipale M,Savchenko A,Ensminger AW
R91025 was used in western blot to determine the extent of Legionella pneumophila maintenance of translocated substrates through a systematic analysis of effector-effector functional interaction
Fri Dec 16 00:00:00 EST 2016
ZBTB7A mutations in acute myeloid leukaemia with t(8;21) translocation.
Nature communications
Hartmann L,Dutta S,Opatz S,Vosberg S,Reiter K,Leubolt G,Metzeler KH,Herold T,Bamopoulos SA,Bräundl K,Zellmeier E,Ksienzyk B,Konstandin NP,Schneider S,Hopfner KP,Graf A,Krebs S,Blum H,Middeke JM,Stölzel F,Thiede C,Wolf S,Bohlander SK,Preiss C,Chen-Wichmann L,Wichmann C,Sauerland MC,Büchner T,Berdel WE,Wörmann BJ,Braess J,Hiddemann W,Spiekermann K,Greif PA
R910-25 was used in Western Blotting to identify recurring ZBTB7A mutations in acute myeloid leukaemia with t(8;21) translocation.
Thu Jun 02 00:00:00 EDT 2016
The Meiotic Recombination Activator PRDM9 Trimethylates Both H3K36 and H3K4 at Recombination Hotspots In Vivo.
PLoS genetics
Powers NR,Parvanov ED,Baker CL,Walker M,Petkov PM,Paigen K
R910-25 was used in Western Blotting to suggest that trimethylation of H3K36 plays an important role in the recombination process.
Wed Jun 01 00:00:00 EDT 2016
Ndfip1 regulates itch ligase activity and airway inflammation via UbcH7.
Journal of immunology (Baltimore, Md. : 1950)
Kathania M,Zeng M,Yadav VN,Moghaddam SJ,Yang B,Venuprasad K
R910-25 was used in western blot to provide mechanistic insights into how Itch function is regulated during inflammatory signaling
Sun Mar 01 00:00:00 EST 2015
Prolyl isomerase Pin1 regulates the osteogenic activity of Osterix.
Molecular and cellular endocrinology
Lee SH,Jeong HM,Han Y,Cheong H,Kang BY,Lee KY
R910-25 was used in western blot to elucidate the mechanism of osterix regulation by post-translational modification
Thu Jan 15 00:00:00 EST 2015
Production and immunological analysis of IgE reactive recombinant egg white allergens expressed in Escherichia coli.
Molecular immunology
Dhanapala P,Doran T,Tang ML,Suphioglu C
R910-25 was used in western blot to report the collective and comparative immunological analysis of all 4 egg white recombinant allergens.
Fri May 01 00:00:00 EDT 2015
The N-terminal Set-β Protein Isoform Induces Neuronal Death.
The Journal of biological chemistry
Trakhtenberg EF,Morkin MI,Patel KH,Fernandez SG,Sang A,Shaw P,Liu X,Wang Y,Mlacker GM,Gao H,Velmeshev D,Dombrowski SM,Vitek MP,Goldberg JL
R910-25 was used in Immunocytochemistry-immunoflourescence to show that an N-terminal Set-Β cleavage product can induce neuronal death.
Fri May 22 00:00:00 EDT 2015
BRD4 regulates Nanog expression in mouse embryonic stem cells and preimplantation embryos.
Cell death and differentiation
Liu W,Stein P,Cheng X,Yang W,Shao NY,Morrisey EE,Schultz RM,You J
R910-25 was used in Immunocytochemistry-immunoflourescence to demonstrate that Bromodomain-containing protein 4 regulates expression of Nanog in both mouse and human embryonic stem cells, mouse preimplantation embryos, and human embryonic cancer stem cells.
Mon Dec 01 00:00:00 EST 2014
Regulating Set-β's Subcellular Localization Toggles Its Function between Inhibiting and Promoting Axon Growth and Regeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Trakhtenberg EF,Wang Y,Morkin MI,Fernandez SG,Mlacker GM,Shechter JM,Liu X,Patel KH,Lapins A,Yang S,Dombrowski SM,Goldberg JL
R910-25 was used in Immunofluorescence to study how Set-β differentially regulates axon growth and regeneration depending on subcellular localization and phosphorylation.
Wed May 21 00:00:00 EDT 2014
Interleukin-22 promotes epithelial cell transformation and breast tumorigenesis via MAP3K8 activation.
Carcinogenesis
Kim K,Kim G,Kim JY,Yun HJ,Lim SC,Choi HS
R910-25 was used in an ELISA assay to assess the role of Il-22 in controlling epithelial cell proliferation and tumourigenesis in the breast.
Sun Jun 01 00:00:00 EDT 2014
Rare GATA5 sequence variants identified in individuals with bicuspid aortic valve.
Pediatric research
Bonachea EM,Chang SW,Zender G,LaHaye S,Fitzgerald-Butt S,McBride KL,Garg V
R910-25 was used in Western Blotting to perform biochemical assays to identify functional deficits in the identified GATA5 sequences of individuals with bicuspid aortic valve.
Fri Aug 01 00:00:00 EDT 2014
Phosphorylation of large T antigen regulates merkel cell polyomavirus replication.
Cancers
Diaz J,Wang X,Tsang SH,Jiao J,You J
R910-25 was used in Immunocytochemistry-immunoflourescence to understand how phosphorylation of LT may dynamically regulate viral replication.
Tue Jul 08 00:00:00 EDT 2014
Accumulation of a repulsive axonal guidance molecule RGMa in amyloid plaques: a possible hallmark of regenerative failure in Alzheimer's disease brains.
Neuropathology and applied neurobiology
Satoh J,Tabunoki H,Ishida T,Saito Y,Arima K
R910-25 was used in Western Blotting to demonstrate RGMa protein interacts with C-terminal fragment β of amyloid beta precursor protein and amyloid plaques and to show that RGM, produced by TGFβ-activated astrocytes and accumulated in amyloid plaques and the glial scar, could contribute to the regenerative failure of degenerating axons in Alzheimer's disease brains.
Fri Feb 01 00:00:00 EST 2013
HTLV-1 HBZ protein deregulates interactions between cellular factors and the KIX domain of p300/CBP.
Journal of molecular biology
Cook PR,Polakowski N,Lemasson I
R910-25 was used in Western Blotting to determine that HTLV-1 basic leucine zipper factor binds with high affinity to the KIX domain of p300/CBP.
Fri Jun 10 00:00:00 EDT 2011
FGF2 promotes Msx2 stimulated PC-1 expression via Frs2/MAPK signaling.
Journal of cellular biochemistry
Li Y,Liu J,Hudson M,Kim S,Hatch NE
R910-25 was used in ChIP assay to study interactions of fibroblast growth factor 2 and Msx2 in pre-osteoblast PC-1 expression.
Wed Dec 01 00:00:00 EST 2010
FGF2 promotes Msx2 stimulated PC-1 expression via Frs2/MAPK signaling.
Journal of cellular biochemistry
Li Y,Liu J,Hudson M,Kim S,Hatch NE
R910-25 was used in ChIP assay to study interactions of fibroblast growth factor 2 and Msx2 in pre-osteoblast PC-1 expression.
Wed Dec 01 00:00:00 EST 2010
Identification of ZASP, a novel protein associated to Zona occludens-2.
Experimental cell research
Lechuga S,Alarcón L,Solano J,Huerta M,Lopez-Bayghen E,González-Mariscal L
R910-25 was used in immunocytochemistry to identify ZASP as a binding partner of ZO-2
Mon Nov 15 00:00:00 EST 2010
Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination.
Nature immunology
Vuong BQ,Lee M,Kabir S,Irimia C,Macchiarulo S,McKnight GS,Chaudhuri J
R910-25 was used in western blot to study the effect of protein kinase A on activation-induced cytidine deaminase
Wed Apr 01 00:00:00 EDT 2009
The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1.
Nature immunology
Venuprasad K,Huang H,Harada Y,Elly C,Subramaniam M,Spelsberg T,Su J,Liu YC
R910-25 was used in Western blot to suggest TIEG and Itch contribute to a ubiquitin-dependent nonproteolytic pathway that regulates inducible Foxp3 expression and control of allergic responses.
Sat Mar 01 00:00:00 EST 2008
Close association of water channel AQP1 with amyloid-beta deposition in Alzheimer disease brains.
Acta neuropathologica
Misawa T,Arima K,Mizusawa H,Satoh J
Mon Sep 01 00:00:00 EDT 2008
Production of sumoylated proteins using a baculovirus expression system.
Journal of virological methods
Langereis MA,Rosas-Acosta G,Mulder K,Wilson VG
R910-25 was used in Western Blotting to provide a simple and convenient means to produce sumoylated mammalian proteins in a eukaryotic environment.
Thu Feb 01 00:00:00 EST 2007
Identification of a novel protein encoded by the latency-related gene of bovine herpesvirus 1.
Journal of neurovirology
Meyer F,Perez S,Jiang Y,Zhou Y,Henderson G,Jones C
R910-25 was used in Western Blotting to suggest that ORF-1 expression may be important for the BHV-1 latency-reactivation cycle.
Sat Dec 01 00:00:00 EST 2007
Interplay between 7SK snRNA and oppositely charged regions in HEXIM1 direct the inhibition of P-TEFb.
The EMBO journal
Barboric M,Kohoutek J,Price JP,Blazek D,Price DH,Peterlin BM
R910-25 was used in Western Blotting to propose a model where the interplay between 7SK snRNA and oppositely charged regions in HEXIM1 direct its binding to P-TEFb and subcellular localization that culminates in the inhibition of transcription.
Wed Dec 21 00:00:00 EST 2005
Protective and therapeutic capacity of human single-chain Fv-Fc fusion proteins against West Nile virus.
Journal of virology
Gould LH,Sui J,Foellmer H,Oliphant T,Wang T,Ledizet M,Murakami A,Noonan K,Lambeth C,Kar K,Anderson JF,de Silva AM,Diamond MS,Koski RA,Marasco WA,Fikrig E
R910-25 was used in immunocytochemistry to determine if recombinant human scFvs specific to the envelope of the West Nile virus are therapeutic
Thu Dec 01 00:00:00 EST 2005
Mutational analysis of the DEAD-box RNA helicase eIF4AII characterizes its interaction with transformation suppressor Pdcd4 and eIF4GI.
RNA (New York, N.Y.)
Zakowicz H,Yang HS,Stark C,Wlodawer A,Laronde-Leblanc N,Colburn NH
R910-25 was used in western blot to determine the role of Pdcd4-eIF4A interactions during translation initiation
Tue Mar 01 00:00:00 EST 2005
Inducible upregulation of oestrogen receptor-beta1 affects oestrogen and tamoxifen responsiveness in MCF7 human breast cancer cells.
Journal of molecular endocrinology
Murphy LC,Peng B,Lewis A,Davie JR,Leygue E,Kemp A,Ung K,Vendetti M,Shiu R
R910-25 was used in Western Blotting to suggest that over-expression of ERbeta1 in the presence of ERalpha is associated with tamoxifen sensitivity but negatively modulates ERalpha-mediated growth.
Fri Apr 01 00:00:00 EST 2005
Characterization of the tight junction protein ZO-2 localized at the nucleus of epithelial cells.
Experimental cell research
Jaramillo BE,Ponce A,Moreno J,Betanzos A,Huerta M,Lopez-Bayghen E,Gonzalez-Mariscal L
R910-25 was used in immunocytochemistry to characterize the nuclear functions of ZO-2
Thu Jul 01 00:00:00 EDT 2004
A PCR-based method for gene deletion and protein tagging in Trypanosoma brucei.
Methods in molecular biology (Clifton, N.J.)
Arhin GK,Shen S,Ullu E,Tschudi C
R910-25 was used in Western Blotting to describe a polymerase chain reaction (PCR)-based method for direct gene deletion and the generation of epitope-tagged fusion proteins.
Wed Jul 28 00:00:00 EDT 2004
A mutation in the latency-related gene of bovine herpesvirus 1 inhibits protein expression from open reading frame 2 and an adjacent reading frame during productive infection.
Journal of virology
Jiang Y,Inman M,Zhang Y,Posadas NA,Jones C
R910-25 was used in Western Blotting to investigate latency-related gene effect of bovine herpesvirus-1.
Mon Mar 01 00:00:00 EST 2004
Putative functional characteristics of human estrogen receptor-beta isoforms.
Journal of molecular endocrinology
Peng B,Lu B,Leygue E,Murphy LC
R910-25 was used in Western Blotting to support promoter-specific differential activities of hERbeta isoforms with respect to models of ERalpha regulated gene expression, and suggest that they may have a role in differentially modulating estrogen action.
Sat Feb 01 00:00:00 EST 2003
Rab11-FIP2 functions in transferrin recycling and associates with endosomal membranes via its COOH-terminal domain.
The Journal of biological chemistry
Lindsay AJ,McCaffrey MW
R910-25 was used in immunocytochemistry to study Rab11-FIP2 and Rab11 in endosomal trafficking
Fri Jul 26 00:00:00 EDT 2002
Promoter-specific activation and demethylation by MBD2/demethylase.
The Journal of biological chemistry
Detich N,Theberge J,Szyf M
R910-25 was used in western blot to investigate the role of MBD2/dMTase as a transcriptional repressor and a DNA methylase
Fri Sep 27 00:00:00 EDT 2002
Mechanisms of regulation of phospholipase D1 and D2 by the heterotrimeric G proteins G13 and Gq.
The Journal of biological chemistry
Xie Z,Ho WT,Spellman R,Cai S,Exton JH
R910-25 was used in western blot to study the effect of phosphorylation and palmitoylation on the activation of rPLD1 by constitutively active Galpha(13)Q226L and Galpha(q)Q209L
Fri Apr 05 00:00:00 EST 2002
PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin.
The Journal of biological chemistry
Steiner H,Winkler E,Edbauer D,Prokop S,Basset G,Yamasaki A,Kostka M,Haass C
R910-25 was used in immunoprecipitation to identify PEN-2 as a critical component of PS1/gamma-secretase and PS2/gamma-secretase complexes
Fri Oct 18 00:00:00 EDT 2002
Contribution of molecular modeling and site-directed mutagenesis to the identification of two structural residues, Arg-220 and Asp-227, in aminopeptidase A.
The Journal of biological chemistry
Rozenfeld R,Iturrioz X,Maigret B,Llorens-Cortes C
R910-25 was used in western blot to develop the first three-dimensional model of a strict aminopeptidase, aminopeptidase A
Fri Aug 09 00:00:00 EDT 2002
FOXC1 transcriptional regulation is mediated by N- and C-terminal activation domains and contains a phosphorylated transcriptional inhibitory domain.
The Journal of biological chemistry
Berry FB,Saleem RA,Walter MA
R910-25 was used in western blot to determine which regions in FOXC1 are required for nuclear localization and transcriptional regulation
Fri Mar 22 00:00:00 EST 2002
A major functional difference between the mouse and human ARF tumor suppressor proteins.
The Journal of biological chemistry
Wadhwa R,Sugihara T,Hasan MK,Taira K,Reddel RR,Kaul SC
R910-25 was used in western blot to study the functional differences between the mouse and human ARF proteins
Fri Sep 27 00:00:00 EDT 2002
Association of Bcr-Abl with the proto-oncogene Vav is implicated in activation of the Rac-1 pathway.
The Journal of biological chemistry
Bassermann F,Jahn T,Miething C,Seipel P,Bai RY,Coutinho S,Tybulewicz VL,Peschel C,Duyster J
R910-25 was used in western blot to study the interactions between Vav and Bcr-Abl
Fri Apr 05 00:00:00 EST 2002
A novel specific role for I kappa B kinase complex-associated protein in cytosolic stress signaling.
The Journal of biological chemistry
Holmberg C,Katz S,Lerdrup M,Herdegen T,Jäättelä M,Aronheim A,Kallunki T
R910-25 was used in immunoprecipitation to describe a novel role for IKAP in the regulating the activation of the mammalian stress response
Fri Aug 30 00:00:00 EDT 2002
Identification of developmentally expressed proteins that functionally interact with Nedd4 ubiquitin ligase.
The Journal of biological chemistry
Murillas R,Simms KS,Hatakeyama S,Weissman AM,Kuehn MR
R910-25 was used in immunoprecipitation to identify and study NEDD4 binding partners in the mid-gestation embryo
Fri Jan 25 00:00:00 EST 2002
The human MDM2 oncoprotein increases the transcriptional activity and the protein level of the p53 homolog p63.
The Journal of biological chemistry
Calabrò V,Mansueto G,Parisi T,Vivo M,Calogero RA,La Mantia G
R910-25 was used in western blot to investigate the effect of MDM2 oncoprotein on the expression of p63
Fri Jan 25 00:00:00 EST 2002
Cloning and characterization of a calcium-binding, histamine-releasing protein from Schistosoma mansoni.
The Journal of biological chemistry
Rao KV,Chen L,Gnanasekar M,Ramaswamy K
R910-25 was used in blocking or activating experiment to study SmTCTP, the Schistosoma mansoni homologue of the mammalian translationally controlled tumor protein (TCTP)
Fri Aug 23 00:00:00 EDT 2002
Glyceraldehyde-3-phosphate dehydrogenase is phosphorylated by protein kinase Ciota /lambda and plays a role in microtubule dynamics in the early secretory pathway.
The Journal of biological chemistry
Tisdale EJ
R910-25 was used in western blot to study the contribution of Rab2 on PKCiota/lambda and GAPDH recruitment to vesicular tubular clusters and microtubule dynamics in the early secretory pathway
Fri Feb 01 00:00:00 EST 2002
Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity.
The Journal of biological chemistry
Niwa J,Ishigaki S,Hishikawa N,Yamamoto M,Doyu M,Murata S,Tanaka K,Taniguchi N,Sobue G
R910-25 was used in immunoprecipitation to show that Dorfin protects neurons by ubiquitylating mutant SOD1 proteins thus targeting them for proteasomal degradation
Fri Sep 27 00:00:00 EDT 2002
Demethylase activity is directed by histone acetylation.
The Journal of biological chemistry
Cervoni N,Szyf M
R910-25 was used in Western Blotting to elucidate a simple mechanism for explaining why active genes are not methylated, maintained by a dynamic balance of methylation and demethylation activities and the local state of histone acetylation.
Fri Nov 02 00:00:00 EST 2001
The absence of activator protein 1-dependent gene expression in THP-1 macrophages stimulated with phorbol esters is due to lack of p38 mitogen-activated protein kinase activation.
The Journal of biological chemistry
Carter AB,Tephly LA,Hunninghake GW
R910-25 was used in western blot to determine if the p38 MAP kinase regulates the transcriptional activity of AP-1 in macrophages
Fri Sep 07 00:00:00 EDT 2001
Targeted deletion of Minpp1 provides new insight into the activity of multiple inositol polyphosphate phosphatase in vivo.
Molecular and cellular biology
Chi H,Yang X,Kingsley PD,O'Keefe RJ,Puzas JE,Rosier RN,Shears SB,Reynolds PR
R910-25 was used in western blot to study inositol polyphosphate phosphatase metabolism and localization using Minpp1-deficient mice
Fri Sep 01 00:00:00 EDT 2000
Uncoupling ceramide glycosylation by transfection of glucosylceramide synthase antisense reverses adriamycin resistance.
The Journal of biological chemistry
Liu YY,Han TY,Giuliano AE,Hansen N,Cabot MC
R910-25 was used in western blot to study the effects of decreased cellular ceramide glycosylation on drug sensitivity and adriamycin resistance in breast cancer cells
Fri Mar 10 00:00:00 EST 2000
A mammalian protein with specific demethylase activity for mCpG DNA.
Nature
Bhattacharya SK,Ramchandani S,Cervoni N,Szyf M
R910-25 was used in western blot to identify a DNA-demethylating enzyme
Thu Feb 18 00:00:00 EST 1999
Molecular cloning of FOG-2: a modulator of transcription factor GATA-4 in cardiomyocytes.
Proceedings of the National Academy of Sciences of the United States of America
Svensson EC,Tufts RL,Polk CE,Leiden JM
R910-25 was used in western blot to identify and characterize FOG-2, a modulator of GATA-4 function during cardiac development
Tue Feb 02 00:00:00 EST 1999
The C terminus of Ku80 activates the DNA-dependent protein kinase catalytic subunit.
Molecular and cellular biology
Singleton BK,Torres-Arzayus MI,Rottinghaus ST,Taccioli GE,Jeggo PA
R910-25 was used in immunoprecipitation to determine the function of Ku80 domains
Sat May 01 00:00:00 EDT 1999
Regulation of alternative polyadenylation by U1 snRNPs and SRp20.
Molecular and cellular biology
Lou H,Neugebauer KM,Gagel RF,Berget SM
R910-25 was used in western blot to investigate the role of SRp20 in alternative polyadenylation
Tue Sep 01 00:00:00 EDT 1998
