Invitrogen

CD10 Monoclonal Antibody (MEM-78), Qdot™ 655

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CD10 Antibody (Q22135) in Flow

Histogram overlay of human leukocytes labeled with CD10 Mouse Anti-Human (clone MEM-78) Qdot® 655 Conjugate. The black line represents cells from the granulocyte gate and the grey line represents cells from the lymphocyte gate. Sample was acquired and analyzed using 405 nm excitation and a 660/20 band pass emission filter using the Attune® Acoustic Cytometer Blue/Violet option (Life Technologies, Carlsbad CA).

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Product Details

Q22135

Applications

Tested Dilution

Publications

Flow Cytometry (Flow)

Assay-dependent

Product Specifications

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

MEM-78

Immunogen

Human CD10.

Conjugate

Qdot™ 655 Qdot™ 655 Qdot™ 655

Excitation/Emission Max

300/654 nm View spectra

Form

Liquid

Storage conditions

4° C

Target Information

CD10 (Common Acute Lymphocytic Leukemia Antigen, CALLA), is a cell surface enzyme with neutral metalloendopeptidase activity which inactivates a variety of biologically active peptides. CD10 is expressed on the cells of lymphoblastic, Burkitt's, and follicular germinal center lymphomas, immature B cells with in adult bone marrow and on cells from patients with chronic myelocytic leukemia (CML). CD10 is also present on breast myoepithelial cells, bile canaliculi, fibroblasts, with especially high expression on the brush border of kidney and gut epithelial cells. CD10 is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. Further, CD10 is a 100 kDa type II transmembrane glycoprotein that exists in a single copy of greater than 45 kb. The 5' untranslated region of the CD10 gene is alternatively spliced, resulting in four separate mRNA transcripts and the coding region is not affected by alternative splicing. Diseases associated with CD10 dysfunction include spinocerebellar ataxia 43 and Charcot-Marie tooth Disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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