Invitrogen

Human LYN A, GST Tag Recombinant Protein

Product Details

PV6450

Applications

Tested Dilution

Publications

Kinase Assay (KA)

Assay-dependent

Product Specifications

Species

Human

Expression System

Baculovirus

Amino acid sequence

Full length

Tag

GST-tag

Molecular weight

81 kDa

Class

Recombinant

Type

Protein

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

purified

Storage buffer

50nM tris HCl, pH 7.5, with 25% glycerol, 0.25mM DTT, 0.1mM EGTA, 150mM NaCl, 0.1mM PMSF, 0.1mM EDTA

Contains

no preservative

Storage conditions

-80° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Dry ice

Product Specific Information

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 µg, 10 µg and 20 µg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 µL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase.

• Increase disease relevance by interrogating a purified and active full-length LYN A reagent
• Uncover novel compounds or hits specific to the full length form
• Advance your research using the full-length protein and validated assays

Assay Platforms:
LanthaScreen™ TR-FRET Kinase Activity Assay
LanthaScreen™ Eu Kinase Binding Assay
Z’-LYTE™ Kinase Activity Assay

Protein Form: Full Length

Target Information

LYN (v-yes-1 Yamaguchi sarcoma viral related oncogene homolog) is a SRC family kinase expressed predominantly in hematopoietic, neural, liver, and adipose tissue. It is a protein-coding gene and is associated with diseases such as alexia and chorea-acanthocytosis. Activation of LYN has been shown to lead to imatinib resistance in CML patients. LYN B and the slightly shorter LYN A are the two isoforms of LYN. An important paralog of Lyn Isoform A is FRK. The full length LYN A protein enables researchers to study important mechanisms underlying disease. Diseases associated with LYN include Sarcoma and Myeloid Leukemia. Among its related pathways are Signaling by Erythropoietin and Regulation of actin dynamics for phagocytic cup formation. Gene Ontology (GO) annotations related to Lyn Isoform A include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of Lyn Isoform A is HCK.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Lck/Yes-related novel protein tyrosine kinase; LYN; p53Lyn; p56Lyn; Tyrosine-protein kinase Lyn; V-yes-1 Yamaguchi sarcoma viral related oncogene homolog