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Product Details
PR8376C
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Conjugate
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Product Specific Information
For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 µg, 10 µg and 20 µg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots; aliquots below 20 µL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase.
Protein Form: Recombinant, Full Length
Target Information
AMP-activated protein kinase (AMPK) is a heterotrimeric complex that acts as sensor of cellular energy levels. The signaling cascades initiated by activating AMPK are critical to regulating metabolic events in the liver, skeletal muscle, heart, adipose tissue, and pancreas. An impairment in fuel metabolism that occurs in obesity is a factor leading to type 2 diabetes. The insulin resistance associated with type 2 diabetes is most profound at the level of skeletal muscle, the primary site of glucose and fatty acid utilization. Activation of AMPK is of interest for the treatment of type 2 diabetes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: 5'-AMP-activated protein kinase beta-1 subunit; 5'-AMP-activated protein kinase catalytic subunit alpha-1; 5'-AMP-activated protein kinase subunit beta-1; 5'-AMP-activated protein kinase subunit gamma-1; 5'-AMP-activated protein kinase, catalytic alpha-1 chain; 5'-AMP-activated protein kinase, gamma-1 subunit; ACACA kinase; Acetyl-CoA carboxylase kinase; AMP -activate kinase alpha 1 subunit; AMP-activated protein kinase beta subunit; AMP-activated protein kinase, catalytic, alpha-1; AMPK alpha 1; AMPK alpha 1/beta 1/gamma 1; AMPK alpha1/beta1/gamma1; AMPK beta -1 chain; AMPK beta 1; AMPK gamma-1 chain; AMPK gamma1; AMPK subunit alpha-1; AMPK subunit beta-1; AMPKb; HMGCR kinase; Hydroxymethylglutaryl-CoA reductase kinase; protein kinase, AMP-activated, alpha 1 catalytic subunit; protein kinase, AMP-activated, beta 1 non-catalytic subunit; protein kinase, AMP-activated, gamma 1 non-catalytic subunit; protein kinase, AMP-activated, noncatalytic, beta-1; Tau-protein kinase PRKAA1
Gene Aliases: AMPK; AMPK1; AMPKa1; AMPKG; HAMPKb; PRKAA1; PRKAB1; PRKAG1
UniProt ID: (Human) Q13131, (Human) Q9Y478, (Human) P54619
Entrez Gene ID: (Human) 5562, (Human) 5564, (Human) 5571
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